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High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-18 Alix Trouillet, Emilie Revol, Florent-Valéry Coen, Florian Fallegger, Aurélie Chanthany, Maude Delacombaz, Laurine Kolly, Ivan Furfaro, Florian Lanz, Vivek Kanumuri, Victor Adenis, Alejandro Garcia-Chavez, M. Christian Brown, Lukas Anschuetz, Jocelyne Bloch, Daniel J. Lee, Stéphanie P. Lacour
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Author Correction: Viscoelastic synthetic antigen-presenting cells for augmenting the potency of cancer therapies Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-15 Zeyang Liu, Yan-Ruide Li, Youcheng Yang, Yu Zhu, Weihao Yuan, Tyler Hoffman, Yifan Wu, Enbo Zhu, Jana Zarubova, Jun Shen, Haochen Nan, Kun-Wei Yeh, Mohammad Mahdi Hasani-Sadrabadi, Yichen Zhu, Ying Fang, Xinyang Ge, Zhizhong Li, Jennifer Soto, Tzung Hsiai, Lili Yang, Song Li
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Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-15 Matthias R. Kollert, Martin Krämer, Nicholas M. Brisson, Victoria Schemenz, Serafeim Tsitsilonis, Taimoor H. Qazi, Peter Fratzl, Viola Vogel, Jürgen R. Reichenbach, Georg N. Duda
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An implantable hydrogel-based phononic crystal for continuous and wireless monitoring of internal tissue strains Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-14 Ye Tian, Yueying Yang, Hanchuan Tang, Jiaxin Wang, Na Li, Yifan Cheng, Tianyu Kang, Jiarui Tang, Mengyuan Zhou, Wei Chen, Yan Yu, Xinqi Liu, Xurui Liu, Liqun Xu, Zhouping Yin, Jianfeng Zang
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In vivo generation of tolerogenic APCs using PDL1 mRNA-loaded nanoparticles Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-09
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Author Correction: Organ-specific metastases obtained by culturing colorectal cancer cells on tissue-specific decellularized scaffolds Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-09 Xi Tian, Michael E. Werner, Kyle C. Roche, Ariel D. Hanson, Henry P. Foote, Stephanie K. Yu, Samuel B. Warner, Jonathan A. Copp, Haydee Lara, Eliane L. Wauthier, Joseph M. Caster, Laura E. Herring, Longzhen Zhang, Joel E. Tepper, David S. Hsu, Tian Zhang, Lola M. Reid, Andrew Z. Wang
Correction to: Nature Biomedical Engineering https://doi.org/10.1038/s41551-018-0231-0, published online 23 April 2018.
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Site-directed antibody conjugation via ubiquitination Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-09
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Site-directed multivalent conjugation of antibodies to ubiquitinated payloads Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-09 Angela F. el Hebieshy, Zacharias Wijfjes, Camille M. Le Gall, Jim Middelburg, Kim E. de Roode, Felix L. Fennemann, Marjolein Sluijter, Thorbald van Hall, Douwe J. Dijkstra, Leendert A. Trouw, Floris J. van Dalen, Andrea Rodgers Furones, Johan M. S. van der Schoot, Ian Derksen, Hans de Haard, Bas van der Woning, Cami M. P. Talavera Ormeño, Bjorn R. van Doodewaerd, Carl G. Figdor, Gerbrand J. van der
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Synthetic data boosts medical foundation models Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-08 Bin Sheng, Pearse A. Keane, Yih-Chung Tham, Tien Yin Wong
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Coordinated AI agents for advancing healthcare Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-01 Michael Moritz, Eric Topol, Pranav Rajpurkar
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Generation of tolerogenic antigen-presenting cells in vivo via the delivery of mRNA encoding PDL1 within lipid nanoparticles Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-28 Yang Liu, Qian Liu, Baowen Zhang, Shanshan Chen, Yanqiong Shen, Zhibin Li, Jiachen Zhang, Yi Yang, Min Li, Yucai Wang
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Osteopontin attenuates the foreign-body response to silicone implants Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-24 Michelle F. Griffin, Jennifer B. Parker, Ruth Tevlin, Norah E. Liang, Caleb Valencia, Annah Morgan, Maxwell Kuhnert, Mauricio Downer, Emily L. Meany, Jason L. Guo, Dominic Henn, Renato S. Navarro, Kerry Shefren, Dung Nguyen, Geoffrey C. Gurtner, Sarah C. Heilshorn, Charles K. F. Chan, Michael Januszyk, Eric A. Appel, Arash Momeni, Derrick C. Wan, Michael T. Longaker
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Cas12a-knock-in mice for multiplexed genome editing, disease modelling and immune-cell engineering Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-20 Kaiyuan Tang, Liqun Zhou, Xiaolong Tian, Shao-Yu Fang, Erica Vandenbulcke, Andrew Du, Johanna Shen, Hanbing Cao, Jerry Zhou, Krista Chen, Hyunu R. Kim, Zhicheng Luo, Shan Xin, Shawn H. Lin, Daniel Park, Luojia Yang, Yueqi Zhang, Kazushi Suzuki, Medha Majety, Xinyu Ling, Stanley Z. Lam, Ryan D. Chow, Ping Ren, Bo Tao, Keyi Li, Adan Codina, Xiaoyun Dai, Xingbo Shang, Suxia Bai, Timothy Nottoli, Andre
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Non-viral intron knock-ins for targeted gene integration into human T cells and for T-cell selection Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-07 Theodore L. Roth, Johnathan Lu, Alison McClellan, Courtney Kernick, Oliver Takacsi-Nagy, Ansuman T. Satpathy
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A deep-learning model for quantifying circulating tumour DNA from the density distribution of DNA-fragment lengths Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-07 Guanhua Zhu, Chowdhury Rafeed Rahman, Victor Getty, Denis Odinokov, Probhonjon Baruah, Hanaé Carrié, Avril Joy Lim, Yu Amanda Guo, Zhong Wee Poh, Ngak Leng Sim, Ahmed Abdelmoneim, Yutong Cai, Lakshmi Narayanan Lakshmanan, Danliang Ho, Saranya Thangaraju, Polly Poon, Yi Ting Lau, Anna Gan, Sarah Ng, Si-Lin Koo, Dawn Q. Chong, Brenda Tay, Tira J. Tan, Yoon Sim Yap, Aik Yong Chok, Matthew Chau Hsien Ng
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Identifying perturbations that boost T-cell infiltration into tumours via counterfactual learning of their spatial proteomic profiles Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-05 Zitong Jerry Wang, Abdullah S. Farooq, Yu-Jen Chen, Aman Bhargava, Alexander M. Xu, Matt W. Thomson
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A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-05 Justin H. Wilde, Yu-Yo Sun, Spenser R. Simpson, Ethan R. Hill, Zhongxiao Fu, Emily J. Bian, Melissa M. Kinkaid, Paulina Villanueva, Aden F. Weybright, William R. Terrell, Zoraiz Qureshi, Shashika S. Perera, Heather S. Sheppard, James R. Stone, Bijoy K. Kundu, Chia-Yi Kuan, Kiel D. Neumann
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A data-efficient strategy for building high-performing medical foundation models Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-05 Yuqi Sun, Weimin Tan, Zhuoyao Gu, Ruian He, Siyuan Chen, Miao Pang, Bo Yan
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Deep mutational learning for the selection of therapeutic antibodies resistant to the evolution of Omicron variants of SARS-CoV-2 Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-05 Lester Frei, Beichen Gao, Jiami Han, Joseph M. Taft, Edward B. Irvine, Cédric R. Weber, Rachita K. Kumar, Benedikt N. Eisinger, Andrey Ignatov, Zhouya Yang, Sai T. Reddy
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3D-printed perfused models of the penis for the study of penile physiology and for restoring erectile function in rabbits and pigs Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-03-04 Zhenxing Wang, Xuemin Liu, Tan Ye, Zhichen Zhai, Kai Wu, Yudi Kuang, Serge Ostrovidov, Dan Shao, Yingjun Wang, Kam W. Leong, Xuetao Shi
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Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-26 Ameya R. Kirtane, Jianling Bi, Netra U. Rajesh, Chaoyang Tang, Miguel Jimenez, Emily Witt, Megan K. McGovern, Arielle B. Cafi, Samual J. Hatfield, Lauren Rosenstock, Sarah L. Becker, Nicole Machado, Veena Venkatachalam, Dylan Freitas, Xisha Huang, Alvin Chan, Aaron Lopes, Hyunjoon Kim, Nayoon Kim, Joy E. Collins, Michelle E. Howard, Srija Manchkanti, Theodore S. Hong, James D. Byrne, Giovanni Traverso
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Enhancing phage therapy by coating single bacteriophage-infected bacteria with polymer to preserve phage vitality Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-25 Sisi Lin, Guocheng Xie, Jun He, Lu Meng, Yan Pang, Jinyao Liu
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Molecular probes for in vivo optical imaging of immune cells Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-21 Jing Liu, Penghui Cheng, Cheng Xu, Kanyi Pu
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Characterization of tumour heterogeneity through segmentation-free representation learning on multiplexed imaging data Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-20 Jimin Tan, Hortense Le, Jiehui Deng, Yingzhuo Liu, Yuan Hao, Michelle Hollenberg, Wenke Liu, Joshua M. Wang, Bo Xia, Sitharam Ramaswami, Valeria Mezzano, Cynthia Loomis, Nina Murrell, Andre L. Moreira, Kyunghyun Cho, Harvey I. Pass, Kwok-Kin Wong, Yi Ban, Benjamin G. Neel, Aristotelis Tsirigos, David Fenyö
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Nitroglycerin-responsive gene switch for the on-demand production of therapeutic proteins Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-14 Mohamed Mahameed, Shuai Xue, Benjamin Danuser, Ghislaine Charpin-El Hamri, Mingqi Xie, Martin Fussenegger
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Microfluidic technologies for enhancing the potency, predictability and affordability of adoptive cell therapies Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-14 Zongjie Wang, Shana O. Kelley
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Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-13 Jinjin Wang, Yuxuan Zhang, Yaru Jia, Haonan Xing, Fengfei Xu, Bozhang Xia, Wenjia Lai, Yuan Yuan, Xianlei Li, Shaobo Shan, Junge Chen, Weisheng Guo, Jinchao Zhang, Aiping Zheng, Jinghong Li, Ningqiang Gong, Xing-Jie Liang
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High-throughput multiplexed serology via the mass-spectrometric analysis of isotopically barcoded beads Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-12 Alexandros P. Drainas, David R. McIlwain, Alec Dallas, Theresa Chu, Antonio Delgado-González, Maya Baron, Maria Angulo-Ibáñez, Angelica Trejo, Yunhao Bai, John W. Hickey, Guolan Lu, Scott Lu, Jesus Pineda-Ramirez, Khamal Anglin, Eugene T. Richardson, John C. Prostko, Edwin Frias, Venice Servellita, Noah Brazer, Charles Y. Chiu, Michael J. Peluso, Jeffrey N. Martin, Oliver F. Wirz, Tho D. Pham, Scott
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A gut-on-a-chip incorporating human faecal samples and peristalsis predicts responses to immune checkpoint inhibitors for melanoma Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-12 Mattia Ballerini, Serena Galiè, Punit Tyagi, Carlotta Catozzi, Hariam Raji, Amir Nabinejad, Angeli D. G. Macandog, Alessandro Cordiale, Bianca Ionela Slivinschi, Karol K. Kugiejko, Martina Freisa, Paola Occhetta, Jennifer A. Wargo, Pier F. Ferrucci, Emilia Cocorocchio, Nicola Segata, Andrea Vignati, Andrey Morgun, Michela Deleidi, Teresa Manzo, Marco Rasponi, Luigi Nezi
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Synaptic connectivity mapping among thousands of neurons via parallelized intracellular recording with a microhole electrode array Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-11 Jun Wang, Woo-Bin Jung, Rona S. Gertner, Hongkun Park, Donhee Ham
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Small circular RNAs as vaccines for cancer immunotherapy Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-07 Yu Zhang, Xiang Liu, Tingting Shen, Qiyan Wang, Shurong Zhou, Suling Yang, Shimiao Liao, Ting Su, Lei Mei, Bei Zhang, Khoa Huynh, Linying Xie, Youzhong Guo, Chunqing Guo, Katarzyna M. Tyc, Xufeng Qu, Xiang-Yang Wang, Jinze Liu, Guizhi Zhu
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Author Correction: Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTENmRNA Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-05 Mohammad Ariful Islam, Yingjie Xu, Wei Tao, Jessalyn M. Ubellacker, Michael Lim, Daniel Aum, Gha Young Lee, Kun Zhou, Harshal Zope, Mikyung Yu, Wuji Cao, James Trevor Oswald, Meshkat Dinarvand, Morteza Mahmoudi, Robert Langer, Philip W. Kantoff, Omid C. Farokhzad, Bruce R. Zetter, Jinjun Shi
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Evolving adeno-associated viruses for gene transfer to the kidney via cross-species cycling of capsid libraries Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-05 Alan Rosales, Leo O. Blondel, Joshua Hull, Qimeng Gao, Nihal Aykun, Jennifer L. Peek, Alejandra Vargas, Sophia Fergione, Mingqing Song, Matthew H. Wilson, Andrew S. Barbas, Aravind Asokan
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Author Correction: A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-02-05 Christopher L. Yankaskas, Keyata N. Thompson, Colin D. Paul, Michele I. Vitolo, Panagiotis Mistriotis, Ankit Mahendra, Vivek K. Bajpai, Daniel J. Shea, Kristen M. Manto, Andreas C. Chai, Navin Varadarajan, Aikaterini Kontrogianni-Konstantopoulos, Stuart S. Martin, Konstantinos Konstantopoulos
Correction to: Nature Biomedical Engineering https://doi.org/10.1038/s41551-019-0400-9, published online 06 May 2019.
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Author Correction: Enhanced control of a brain–computer interface by tetraplegic participants via neural-network-mediated feature extraction Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-29 Benyamin Haghi, Tyson Aflalo, Spencer Kellis, Charles Guan, Jorge A. Gamez de Leon, Albert Yan Huang, Nader Pouratian, Richard A. Andersen, Azita Emami
Correction to: Nature Biomedical Engineering https://doi.org/10.1038/s41551-024-01297-1, published online 6 December 2024.
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Urinary bioorthogonal reporters for the monitoring of the efficacy of chemotherapy for lung cancer and of associated kidney injury Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-29 Penghui Cheng, Ziling Zeng, Jing Liu, Si Si Liew, Yuxuan Hu, Mengke Xu, Kanyi Pu
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Author Correction: Endocisternal interfaces for minimally invasive neural stimulation and recording of the brain and spinal cord Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-27 Joshua C. Chen, Abdeali Dhuliyawalla, Robert Garcia, Ariadna Robledo, Joshua E. Woods, Fatima Alrashdan, Sean O’Leary, Adam Husain, Anthony Price, Scott Crosby, Michelle M. Felicella, Ajay K. Wakhloo, Patrick Karas, Nicole Provenza, Wayne Goodman, Sameer A. Sheth, Sunil A. Sheth, Jacob T. Robinson, Peter Kan
Correction to: Nature Biomedical Engineering https://doi.org/10.1038/s41551-024-01281-9, published online 11 November 2024.
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A generalist model for enhancing brain MRIs Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-24 Yael Balbastre, Bruce Fischl
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Author Correction: Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-20 Moritz Hofer, Maria A. Duque-Correa, Matthias P. Lutolf
Correction to: Nature Biomedical Engineering https://doi.org/10.1038/s41551-024-01313-4, published online 4 December 2024.
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Author Correction: Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-16 Bowen Li, Allen Yujie Jiang, Idris Raji, Caroline Atyeo, Theresa M. Raimondo, Akiva G. R. Gordon, Luke H. Rhym, Tahoura Samad, Corina MacIsaac, Jacob Witten, Haseeb Mughal, Taras M. Chicz, Yue Xu, Ryan P. McNamara, Sangeeta Bhatia, Galit Alter, Robert Langer, Daniel G. Anderson
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Author Correction: Dynamical flexible inference of nonlinear latent factors and structures in neural population activity Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-15 Hamidreza Abbaspourazad, Eray Erturk, Bijan Pesaran, Maryam M. Shanechi
Correction to: Nature Biomedical Engineering https://doi.org/10.1038/s41551-023-01106-1, published online 11 December 2023.
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Therapeutic precision, potency and promise Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-15
Advances in base editing and prime editing, coupled with optimized delivery strategies, are enhancing the efficiency, safety and versatility of genome editing for the treatment of a widening range of genetic diseases.
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Moving beyond single-electrode intracortical-microstimulation-evoked tactile perception Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-10
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Interpretable identification of cancer genes across biological networks via transformer-powered graph representation learning Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-09 Xiaorui Su, Pengwei Hu, Dongxu Li, Bowei Zhao, Zhaomeng Niu, Thomas Herget, Philip S. Yu, Lun Hu
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A lifespan-generalizable skull-stripping model for magnetic resonance images that leverages prior knowledge from brain atlases Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-01-08 Limei Wang, Yue Sun, Jakob Seidlitz, Richard A. I. Bethlehem, Aaron Alexander-Bloch, Lena Dorfschmidt, Gang Li, Jed T. Elison, Weili Lin, Li Wang
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Sharing antigens from stem cell membranes Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-27 Yuewen Zhai, Siwen Li
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Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-27 Jeffrey Herron, Aura Kullmann, Timothy Denison, Wayne K. Goodman, Aysegul Gunduz, Wolf-Julian Neumann, Nicole R. Provenza, Maryam M. Shanechi, Sameer A. Sheth, Philip A. Starr, Alik S. Widge
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Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-27 Nan Li, Hao Qin, Fei Zhu, Hao Ding, Yang Chen, Yixuan Lin, Ronghui Deng, Tianyu Ma, Yuanyuan Lv, Changhao Xiong, Rong Li, Yaohua Wei, Jian Shi, Hanqing Chen, Yuliang Zhao, Guangbiao Zhou, Hua Guo, Mengyao Lv, Yongfang Lin, Bing Han, Guangjun Nie, Ruifang Zhao
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An antifibrotic therapy for myocardial infarction Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-23 Valeria Caprettini
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Insulin independence from stem-cell-derived islets Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-23 Alessandra Griffo
An autologous transplant of islets derived from chemically induced pluripotent stem cells allowed an individual with type 1 diabetes to forgo insulin.
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Targeting NK2R reverses cardiometabolic dysfunction Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-23 Jennifer Haskell
An agonist of the neurokinin 2 receptor induced weight loss and increased energy expenditure in obese mice and monkeys with diabetes.
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Nanoprobes for X-ray-mediated theranostics Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-23 Jennifer Haskell
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An application-based taxonomy for brain–computer interfaces Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-23 Jacob T. Robinson, Sumner L. Norman, Matthew R. Angle, Timothy G. Constandinou, Timothy Denison, John P. Donoghue, Ryan M. Field, Andreas Forsland, Sid Kouider, José del R. Millán, Jonathan A. Michaels, Amy L. Orsborn, Chethan Pandarinath, J. Andrew Pruszynski, Christopher J. Rozell, Nishal P. Shah, Maryam M. Shanechi, Mahsa Shoaran, Sameer A. Sheth, Sergey D. Stavisky, Eric Trautmann, Nicolas Vachicouras
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Synthetic multimodal data modelling for data imputation Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-23 Francisco Carrillo-Perez, Marija Pizurica, Kathleen Marchal, Olivier Gevaert
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Prediction of metabolic subphenotypes of type 2 diabetes via continuous glucose monitoring and machine learning Nat. Biomed. Eng. (IF 26.8) Pub Date : 2024-12-23 Ahmed A. Metwally, Dalia Perelman, Heyjun Park, Yue Wu, Alokkumar Jha, Seth Sharp, Alessandra Celli, Ekrem Ayhan, Fahim Abbasi, Anna L. Gloyn, Tracey McLaughlin, Michael P. Snyder
更新日期：2025-04-18
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