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MIDMID-TERM KIDNEY FUNCTION IN BOYS WITH POSTERIOR URETHRAL VALVES AND A SOLITARY FUNCTIONING KIDNEY. J. Urol. (IF 5.9) Pub Date : 2025-05-16 Silvia Pecorelli,Mathilde Glenisson,Matthieu Peycelon,Etienne Suply,Marc-David Leclair,Nicolas Kalfa,Pauline Clermidi,Alexis Arnaud,Alice Faure,Quentin Ballouhey,Nadia Boudaoud,Yann Chaussy,Cyril Ferdynus,Thomas Blanc,Luke Harper
PURPOSE It has been suggested that patients with Posterior Urethral Valves (PUV) and a solitary functioning kidney (SFK) have poorer mid-term and long-term renal function than those with 2 functioning kidneys (2FK). We compared mid-term eGFR of PUV patients with and without solitary kidneys. MATERIAL AND METHODS We used the CIRCUP randomized controlled trial database, which included only patients with
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Reply: Letter: a multi-institutional study of MR/US fusion guided nanoparticle directed focal therapy for prostate ablation. J. Urol. (IF 5.9) Pub Date : 2025-05-07 Steven E Canfield,Ardeshir R Rastinehad
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Magnetic Resonance Imaging at second surveillance biopsy after diagnosis in patients with Grade Group 1 prostate cancer in the Canary Prostate Active Surveillance Study. J. Urol. (IF 5.9) Pub Date : 2025-04-30 Meera R Chappidi,Lisa F Newcomb,Yingye Zheng,Menghan Liu,Jeannette M Schenk,Kehao Zhu,Claire M de la Calle,James D Brooks,Peter R Carroll,Atreya Dash,Christopher P Filson,Martin E Gleave,Michael A Liss,Frances Martin,Jesse K McKenney,Todd M Morgan,Andrew A Wagner,Peter S Nelson,Daniel W Lin
PURPOSE No clear guidelines exist regarding MRI use after confirmatory biopsy during active surveillance (AS). Our objective was to evaluate MRI performance after confirmatory biopsy in patients with vs. without prior MRI-informed biopsy. METHODS Patients in Canary PASS with Gleason grade group (GG) 1 disease undergoing MRI-informed Biopsy 2, defined as second surveillance biopsy after diagnosis, were
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The AUA/SUFU/AUGS Guideline on Genitourinary Syndrome of Menopause. J. Urol. (IF 5.9) Pub Date : 2025-04-29 Melissa R Kaufman,A Lenore Ackerman,Katherine A Amin,Marge Coffey,Elisheva Danan,Stephanie S Faubion,Anne Hardart,Irwin Goldstein,Giulia M Ippolito,Gina M Northington,Charles R Powell,Rachel S Rubin,O Lenaine Westney,Tracey S Wilson,Una J Lee
PURPOSE Genitourinary syndrome of menopause (GSM) describes the symptoms and physical changes that result from declining estrogen and androgen concentrations in the genitourinary tract during the menopausal transition. There has not been a consensus reached about the number or type of symptoms needed to diagnose GSM, and the associated urinary symptoms are also linked with other common urologic conditions
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Predicting Recurrence After Surgical Resection for High-Risk Localized Renal Cell Carcinoma: A Radiomics Clinical Integration Approach. J. Urol. (IF 5.9) Pub Date : 2025-04-28 Zine-Eddine Khene,Raj Bhanvadia,Isamu Tachibana,Prajwal Sharma,William Graber,Theophile Bertail,Raphael Fleury,Renaud De Crevoisier,Karim Bensalah,Yair Lotan,Vitaly Margulis
PURPOSE Adjuvant immunotherapy for clear cell renal cell carcinoma (ccRCC) is controversial because of the absence of reliable biomarkers for identifying patients most likely to benefit. The aim of this study was to develop and validate a quantitative radiomics signature (RS) and a radiomics clinical model to identify patients at increased risk of recurrence after surgery among those eligible for adjuvant
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Pelvic lymph node dissection in prostate cancer - is it really necessary? A multicentric longitudinal study assessing oncological outcomes in prostate cancer patients undergoing pelvic lymph node dissection vs radical prostatectomy only. J. Urol. (IF 5.9) Pub Date : 2025-04-28 Marc A Furrer,Niranjan J Sathianathen,Clancy J Mulholland,Nathan Papa,Andreas Katsios,Christopher Soliman,Nathan Lawrentschuk,Justin S Peters,Homi Zargar,Anthony J Costello,Christopher M Hovens,Peter Liodakis,Conrad Bishop,Ranjit Rao,Raymond Tong,Daniel Steiner,Declan G Murphy,Daniel Moon,Benjamin C Thomas,Philip Dundee,Jeremy Goad,Jose Antonio Rodriguez Calero,George N Thalmann,Niall Corcoran
PURPOSE With the availability of PSMA-PET scans, it is controversial whether pelvic lymph-node dissection (PLND) at time of radical prostatectomy (RP) is still the most reliable and accurate staging modality for lymph-node assessment. Furthermore, the oncological benefit of PLND remains unclear. Aim of this study was to assess whether omitting PLND in patients undergoing RP for prostate cancer is associated
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Editorial Comment: Re: Utility of Preoperative Antimicrobial Prophylaxis in Hypospadias Repair: Results from NSQIP-Pediatric. J. Urol. (IF 5.9) Pub Date : 2025-04-28 Douglas E Coplen
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Editorial Comment on "Effect of Chlorthalidone and Hydrochlorothiazide on Twelve-Hour Versus 24-Hour Calcium Excretion". J. Urol. (IF 5.9) Pub Date : 2025-04-28 Vernon M Pais
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Utility of Preoperative Antimicrobial Prophylaxis in Hypospadias Repair: Results From NSQIP-Pediatrics. J. Urol. (IF 5.9) Pub Date : 2025-04-28 Karen M Doersch,David A Diamond
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A Prospective Randomized Study on Low-Energy Extracorporeal Shockwave Therapy for Erectile Dysfunction After Radical Prostatectomy. J. Urol. (IF 5.9) Pub Date : 2025-04-28 Torben Brøchner Pedersen,Caroline Secher,Ali Moumneh,Nanna Hvid,Martin Lund,Grzegorz Fojecki,Lars Lund
PURPOSE To evaluate the efficacy of low-energy extracorporeal shockwave therapy (LI-SWT) compared with a sham treatment in improving erectile function in men after radical prostatectomy. Erectile function was assessed using the Erection Hardness Score (EHS) and International Index of Erectile Function (IIEF) at baseline and 4, 12, and 24 weeks after treatment. MATERIALS AND METHODS A total of 75 participants
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Acoustic Enhancer Microbubble Cavitation: A Randomized Clinical Trial Evaluating the Safety and Efficacy of a Novel Treatment for Urolithiasis. J. Urol. (IF 5.9) Pub Date : 2025-04-26 Wesley A Mayer,Thomas Chi,Scott Wiener,Christopher H Cantrill,Julio G Davalos,Hemendra N Shah,Marshall L Stoller
PURPOSE The efficacy of ureteroscopy to treat urinary stones is often less than 60%. Acoustic Enhancer is an investigational device of microparticles with a tag designed with an affinity for calcium. We evaluated safety and efficacy of ureteroscopic laser lithotripsy with and without Acoustic Enhancer Microbubble Cavitation in a randomized clinical trial. MATERIALS AND METHODS Patients with urolithiasis
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Do Prophylactic Antibiotics Decrease the Rate of Urinary Tract Infections after Robot-Assisted Radical Cystectomy? A Randomized Controlled Trial. J. Urol. (IF 5.9) Pub Date : 2025-04-25 Ahmed A Hussein,Abdul Wasay Mahmood,Ali Ahmad,Holly Houenstein,Grace Harrington,Mohammad Khan,Dawod Abdelhaq,Zhe Jing,Kristopher Attwood,Nikolaos G Almyroudis,Qiang Li,Khurshid A Guru
OBJECTIVE To investigate the role of prophylactic antibiotics after robot-assisted radical cystectomy (RARC) in the prevention of 90-day urinary tract infections (UTIs). METHODS Patients who underwent RARC with urinary diversion were randomized to standard of care (SOC) versus receiving prophylactic antibiotics (Nitrofurantoin 100 mg daily or trimethoprim/sulfamethoxazole 160/800 mg daily) for 30 days
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Active Surveillance versus Primary Intervention for Clinical T1a Kidney Tumors: Twelve-Year Experience of the DISSRM Prospective Comparative Study. J. Urol. (IF 5.9) Pub Date : 2025-04-22 Khalid Y Alkhatib,Joseph G Cheaib,Maximilian Pallauf,Ridwan Alam,Hiten D Patel,Tina Wlajnitz,Nirmish Singla,Peter Chang,Andrew A Wagner,Christian P Pavlovich,James M McKiernan,Thomas J Guzzo,Mohamad E Allaf,Phillip M Pierorazio
PURPOSE Active surveillance (AS) is an alternative to primary intervention (PI) in the management of small renal masses (SRMs; clinical stage T1a). However, AS remains underutilized due to a lack of strong, prospective data. We herein report mature outcomes after a twelve-year experience with the Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) Registry. MATERIALS AND METHODS Multi-institutional
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Evolution of Active Surveillance of Prostate Cancer: Impact of Magnetic Resonance Imaging, Magnetic Resonance Imaging-Guided Biopsy, and Focal Therapy. J. Urol. (IF 5.9) Pub Date : 2025-04-21 Shannon C Martin,Samantha Gonzalez,Lorna Kwan,Merdie Delfin,Anissa V Nguyen,Wayne Brisbane,Ely Felker,Anthony Sisk,Alan Priester,Shyam Natarajan,Leonard S Marks
PURPOSE We aimed to determine if, using baseline MRI-guided biopsy (MRGB), durability of active surveillance (AS) could be predetermined, follow-up biopsies avoided, and if by incorporating focal therapy (FT), AS extended. MATERIALS AND METHODS A cohort of 869 men in the University of California, Los Angeles, protocol study of AS (2010-2022) was analyzed. Inclusion criteria were baseline MRGB showing
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Male Chronic Pelvic Pain: AUA Guideline: Part I Evaluation and Management Approach. J. Urol. (IF 5.9) Pub Date : 2025-04-17 H Henry Lai,Michel A Pontari,Charles E Argoff,Larissa Bresler,Benjamin N Breyer,Roger Chou,J Quentin Clemens,Elise Jb De,R Christopher Doiron,Dane Johnson,Erin Kirkby,Susan M MacDonald,Jill H Osborne,Sijo J Parekattil,Beth Shelly
PURPOSE This Guideline covers the evaluation and treatment of men who present to a clinician with a complaint of chronic pelvic pain. This is Part I of a three-part series focusing on the evaluation of such patients. The presentation of these men is widely variable. In addition to pelvic pain, they may also have pain in many body areas outside of the pelvis. The wide variety of clinical presentations
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Male Chronic Pelvic Pain: AUA Guideline: Part III Treatment of Chronic Scrotal Content Pain. J. Urol. (IF 5.9) Pub Date : 2025-04-17 H Henry Lai,Michel A Pontari,Charles E Argoff,Larissa Bresler,Benjamin N Breyer,Roger Chou,J Quentin Clemens,Elise Jb De,R Christopher Doiron,Dane Johnson,Erin Kirkby,Susan M MacDonald,Jill H Osborne,Sijo J Parekattil,Beth Shelly
PURPOSE This Guideline covers the evaluation and treatment of men who present to a clinician with a complaint of chronic pelvic pain. This is Part III of a three-part series focusing on treatment of chronic scrotal content pain (CSCP). CSCP patients typically present with pain described in the testes with tenderness in the epididymis and/or spermatic cord. Patient education of the underlying etiology
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Male Chronic Pelvic Pain: AUA Guideline: Part II Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome. J. Urol. (IF 5.9) Pub Date : 2025-04-17 H Henry Lai,Michel A Pontari,Charles E Argoff,Larissa Bresler,Benjamin N Breyer,Roger Chou,J Quentin Clemens,Elise Jb De,R Christopher Doiron,Dane Johnson,Erin Kirkby,Susan M MacDonald,Jill H Osborne,Sijo J Parekattil,Beth Shelly
PURPOSE This Guideline covers the evaluation and treatment of men who present to a clinician with a complaint of chronic pelvic pain. This is Part II of a three-part series focusing on treatment of chronic prostatitis/ chronic pelvic pain syndrome (CP/CPPS). A challenge for clinicians treating these patients is the necessity to address symptoms and etiologies outside of the usual urologic evaluation
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AI Biomarkers Predict Poor Efficacy of BCG Rechallenge in Previously BCG-Treated Non-muscle Invasive Bladder Cancer. J. Urol. (IF 5.9) Pub Date : 2025-04-16 Yair Lotan,Roger Li,Sam S Chang
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Letter: Updates to Microhematuria: AUA/SUFU Guideline (2025). J. Urol. (IF 5.9) Pub Date : 2025-04-15 Karim Chamie,Andrew Chen,Alejandro Rodriguez,Wei Shen Tan
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Accuracy of 18F-Fluorodeoxyglucose Positron Emission Tomography in Early Metastatic Testicular Seminoma: Analysis From the SEMS Trial. J. Urol. (IF 5.9) Pub Date : 2025-04-09 Brian Hu,Muhannad Alsyouf,Ala'a Farkouh,Clint Cary,Timothy Masterson,Lawrence Einhorn,Nabil Adra,Stephen A Boorjian,Christian Kollmannsberger,Anne Schuckman,Alan So,Peter C Black,Aditya Bagrodia,Eila Skinner,Mehrdad Alemozaffar,Timothy Brand,Scott Eggener,Phillip Pierorazio,Kelly Stratton,Lucia Nappi,Craig Nichols,Siamak Daneshmand
PURPOSE Recent clinical trials on primary retroperitoneal lymph node dissection (RPLND) for testicular seminoma highlight inaccuracies in conventional imaging for lymph node staging. Limited data exist on the accuracy of positron emission tomography (PET) in patients with chemotherapy-naïve testicular seminoma. We evaluated the accuracy of 18F-fluorodeoxyglucose (FDG) PET for the detection of metastatic
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A Comparison of Stockholm3, Serum Biomarkers, and Risk Calculators to Predict Prostate Cancer in a Racially and Ethnically Diverse Cohort: Evaluation of the Stockholm3 Multiethnic SEPTA Trial. J. Urol. (IF 5.9) Pub Date : 2025-04-09 Alon Lazarovich,Hari Vigneswaran,Thorgerdur Palsdottir,Martin Eklund,Andrea Discacciati,Tobias Nordström,Rebecca A Hubbard,Nathan Perlis,Michael R Abern,Daniel M Moreira,Paul Yonover,Alexander K Chow,Kara Watts,Michael A Liss,Gregory R Thoreson,Andre L Abreu,Geoffrey A Sonn,Anna Plym,Fredrik Wiklund,Henrik Grönberg,Adam B Murphy,Scott Eggener
PURPOSE The purpose of this study was to compare performance of Stockholm3 in an external validation with commonly used prostate cancer biomarkers and risk calculators. MATERIALS AND METHODS SEPTA was a multicenter trial validating Stockholm3 in a racially/ethnically diverse population of men meeting local care guidelines for prostate biopsy (2019-2023). In total, 2115 (98%) men with complete data
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Effect of Chlorthalidone and Hydrochlorothiazide on 12-Hour vs 24 Hour Urinary Calcium Excretion. J. Urol. (IF 5.9) Pub Date : 2025-04-07 Daniel A Wollin,Hassan Fattah,John R Asplin,David S Goldfarb
PURPOSE Urine calcium excretion (UCa) is greater after dinner and urine volumes are lower. The result is higher urine calcium concentrations, which may confer greater risk of stone formation, at night. We considered whether night-time administration-as compared with daytime administration-of thiazides would be more effective for stone prevention. MATERIALS AND METHODS We performed 12-hour urine collections
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Utility of Preoperative Antimicrobial Prophylaxis in Hypospadias Repair: Results From National Surgical Quality Improvement Program-Pediatrics. J. Urol. (IF 5.9) Pub Date : 2025-04-03 Michael F Basin,Maithili Gopalakrishnan,Nicole Ackerman,Matthew D Mason,Anthony J Tracey,Ahmed Souid,Jeffrey A Villanueva
PURPOSE Literature supporting antimicrobial prophylaxis for hypospadias repairs is lacking, with largest studies including several hundred subjects. We sought to evaluate the association of a single dose of preoperative antibiotics in hypospadias repairs on postoperative outcomes using the National Surgical Quality Improvement Program-Pediatrics. MATERIALS AND METHODS The 2021 to 2022 National Surgical
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Machine Learning Analysis of Videourodynamics to Predict Incident Hydronephrosis in Patients With Spina Bifida. J. Urol. (IF 5.9) Pub Date : 2025-03-25 John K Weaver,Joseph Logan,Jason P Van Batavia,Dana A Weiss,Christopher J Long,Ariana L Smith,Stephen A Zderic,Zoe Gan,Karl Godlewski,Reiley Broms,Maria Antony,Maya Overland,Tyler Gaines,Dennis Head,Lauren Erdman,Bernarda Viteri,Madalyne Martin-Olenski,Jing Huang,Yong Fan,Gregory E Tasian
PURPOSE Variability in the interpretation of videourodynamics studies limits reliable classification of kidney injury risk for patients with spina bifida. We developed machine learning models to predict incident hydronephrosis in patients with spina bifida using videourodynamics data. MATERIALS AND METHODS We trained machine learning models using data from videourodynamics studies performed between
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Lower Testosterone Level and Metastases-Free Survival in Patients With Nonmetastatic Castration-Resistant Prostate Cancer Treated With Novel Antiandrogens: A Post Hoc Analysis of SPARTAN and ARAMIS. J. Urol. (IF 5.9) Pub Date : 2025-03-25 Xudong Ni,Jixinnan Sui,Beihe Wang,Hongkai Wang,Stephen J Freedland,Dingwei Ye,Yao Zhu
PURPOSE The EAU guidelines and the latest recommendations from the US Prostate Cancer Conference suggest a castration threshold of 20 ng/dL. However, the current NCCN and AUA guidelines still recommend a castration standard of 50 ng/dL. It remains unknown whether there is a relationship between maintaining lower testosterone levels and the prognosis of patients with nonmetastatic castration-resistant
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Hybrid 3-Tier Bladder Cancer Grade: The Mutually Beneficial Marriage of 2 Grading Systems. J. Urol. (IF 5.9) Pub Date : 2025-03-25 Ashish M Kamat,Bas W G van Rhijn,Theodorus Van der Kwast
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Facilitated Clearance of Small, Asymptomatic Renal Stones With Burst Wave Lithotripsy and Ultrasonic Propulsion. J. Urol. (IF 5.9) Pub Date : 2025-03-17 Jonathan D Harper,Barbrina Dunmire,Jeff Thiel,Barbara H Burke,Yak-Nam Wang,Stephanie Totten,John C Kucewicz,Adam D Maxwell,M Kennedy Hall,Arturo E Holmes,Christina Popchoi,James E Lingeman,Alana C Desai,Robert M Sweet,Manjiri Dighe,Branda J Levchak,Claire C Yang,Michael R Bailey,Mathew D Sorensen
PURPOSE We tested feasibility of burst wave lithotripsy (BWL) and ultrasonic propulsion to noninvasively fragment and expel small, asymptomatic renal stones in awake participants. MATERIALS AND METHODS Adult patients suspected of having 2- to 7-mm stones were consented and screened for eligibility. BWL and ultrasonic propulsion were applied to up to 3 stones in 1 kidney of qualifying participants for
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Childhood Functional Urinary Incontinence and School Performance: A Nationwide Matched Cohort Study. J. Urol. (IF 5.9) Pub Date : 2025-03-17 Britt Borg,Betina B Trabjerg,Julie Werenberg Dreier,Søren Rittig,Anders Breinbjerg,Jakob Christensen,Kristian Juul,Per Hove Thomsen,Konstantinos Kamperis
PURPOSE Childhood urinary incontinence (UI) is a common disorder with significant negative impact on self-esteem and quality of life, but the impact on school performance is unknown. This study investigates how UI in children is associated with school performance. MATERIALS AND METHODS This is a nationwide matched cohort study of children born in Denmark to Danish parents between 1997 and 2008 investigating
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Negative Predictive Value of a Prostate MRI in Black Men: Implications for Biopsy Decision-Making. J. Urol. (IF 5.9) Pub Date : 2025-03-17 Sarah Sandlow,Samuel Carbunaru,Zequn Sun,Bernice Ofori,Yingzhe Liu,Eric Li,Courtney M P Hollowell,Patricia Vidal,Kent T Perry,Hiten D Patel,Ryan W Dobbs,David D Casalino,Cecil G Wood,Anugayathri Jawahar,Channa Amarasekera,Jeanne M Horowitz,Frank H Miller,Emrah Gumusgoz,Ximing J Yang,Bonnie Choy,Frances Manosca,Ulas Bagci,Edward M Schaeffer,Peter Gann,Dustin D French,Ashley E Ross,Shilajit D Kundu,Adam
PURPOSE Prostate Imaging Reporting and Data System (PIRADS) v2.1 scoring with multiparametric (mp) MRI has a pooled 90% negative predictive value (NPV). PSA density (PSAD) ≤ 0.15 ng/mL/cm3 has been shown to enhance mpMRI's NPV in non-Black men. Populations with higher disease prevalence are known to have lower NPVs. Given that Black men have higher prostate cancer prevalence, we evaluate sensitivity
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Comparison of Complication and Readmission Rates Between Robot-Assisted and Open Radical Cystectomy: Results From the Randomized RAZOR Clinical Trial. J. Urol. (IF 5.9) Pub Date : 2025-03-13 Vivek Venkatramani,Isildinha M Reis,Mark L Gonzalgo,Sanjaya Swain,Robert S Svatek,Dipen J Parekh
PURPOSE We assessed differences in complications and readmissions between robot-assisted radical cystectomy (RARC) and open radical cystectomy (ORC). MATERIALS AND METHODS This study uses data from the per-protocol population of the Randomized Robotic-Assisted vs Open Radical Cystectomy (RAZOR) study, a multicenter, open-label, phase 3, noninferiority clinical trial. RAZOR enrolled across 15 academic
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Intermediate-Term Oncologic Outcomes of Partial Nephrectomy vs Cryoablation in Renal Tumors > 3 cm: A Propensity Score-Matched Analysis. J. Urol. (IF 5.9) Pub Date : 2025-03-12 Nicholas A Pickersgill,Joel M Vetter,Dylan J Mittauer,Lauren Elson,Joshua K Palka,Nimrod S Barashi,Eric H Kim,Ramakrishna Venkatesh,Sam B Bhayani,R Sherburne Figenshau
PURPOSE Cryoablation (CA) and partial nephrectomy (PN) are effective nephron-sparing treatments of small renal masses. While guidelines list thermal ablation as an option for tumors < 3 cm, limited data compare PN and CA in larger tumors. We compared intermediate-term oncologic outcomes between PN and CA in renal masses > 3 cm. MATERIALS AND METHODS Patients treated with PN or CA for cT1/cT2, N0M0
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HF01-01 The "Exhibition of Living Patients"-Hutchinson, Ethics and Urology: Erratum. J. Urol. (IF 5.9) Pub Date : 2025-03-07 Shelby P Smith,Michael E Moran
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Perceived Impact on Patient Routines/Responsibilities for Surgery and a Nonsurgical Primary Treatment Option in Recurrent Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer: Findings From the ENVISION Phase 3 Trial. J. Urol. (IF 5.9) Pub Date : 2025-03-06 Angela M Stover,Dana Mueller,Jessica Carda-Auten,Alison Hilton,Victoria Tsurutis,Angela B Smith
PURPOSE Adults with low-grade intermediate-risk NMIBC commonly ask urologists how their routine/responsibilities will be affected by treatments, including the standard of care, transurethral resection of bladder tumor (TURBT). We asked patients in the ENVISION trial to compare TURBT with a nonsurgical primary treatment (UGN-102 containing mitomycin) for acceptability and impact on their routine/responsibilities
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Prostate Size and Its Effect on Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia Improvement After Convective Water Vapor Thermal Therapy. J. Urol. (IF 5.9) Pub Date : 2025-03-05 Owen Lewer,Michael D Felice,Olivia Copelan,Sarang Janakiraman,Gaurav Pahouja,Amy Wozniak,Kevin T McVary
PURPOSE Lower urinary tract symptoms due to benign prostatic hyperplasia (LUTS/BPH) affects quality of life. Convective water vapor thermal therapy (CWVTT-Rezum) is a minimally invasive surgical treatment for LUTS/BPH which produces significant improvement of LUTS in men with prostates between 30 cc and 80 cc with minimal de novo sexual dysfunction. However, outcomes across the prostate volume (PV)
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Is Excretory-Phase Computerized Tomography Important for Evaluation of Pediatric High-Grade Renal Trauma? J. Urol. (IF 5.9) Pub Date : 2025-03-03 Ching Man Carmen Tong,Luke Shumaker,Jacob Lucas,Vinaya Bhatia,Albert Lee,Benjamin Abelson,Gabriella L Crane,Christina Ho,Christopher J Long,Robert T Russell,Harold N Lovvorn,Ming-Hsien Wang,Dana A Weiss,Douglass B Clayton,David M Kitchens
PURPOSE There are no standardized guidelines for evaluation of pediatric renal trauma. We hypothesize that screening radiographic studies performed to rule out traumatic renal injuries in children can initially be evaluated by contrast-enhanced CT scans that lack an excretory phase. MATERIALS AND METHODS We retrospectively collected data from 5 pediatric trauma centers between 2007 to 2020. Patients
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Updates to Microhematuria: AUA/SUFU Guideline (2025). J. Urol. (IF 5.9) Pub Date : 2025-02-27 Daniel A Barocas,Yair Lotan,Richard S Matulewicz,Jay D Raman,Mary E Westerman,Erin Kirkby,Lauren J Pak,Lesley Souter
PURPOSE In 2023 the AUA in collaboration with the Society for Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction (SUFU) requested an Update Literature Review to incorporate new evidence generated since the 2020 publication of this Guideline. The resulting 2025 Microhematuria Guideline Amendment addresses updated recommendations to provide a clinical framework for the diagnosis, evaluation
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A Phase 2 Study of Tislelizumab as Neoadjuvant Treatment of Cisplatin-Ineligible High-Risk Upper Tract Urothelial Carcinoma. J. Urol. (IF 5.9) Pub Date : 2025-02-25 Jiwei Huang,Xingyun Cai,Cheoklong Ng,Yuansheng Luo,Qiong Chen,Zaoyu Wang,Keying Qiao,Wen Kong,Jin Zhang,Yonghui Chen,Wei Zhang,Jiyang Zhang,Dadong Zhang,Guangyu Wu,Haige Chen,Wei Xue
PURPOSE We investigated the efficacy and safety of tislelizumab as neoadjuvant therapy in patients with cisplatin-ineligible high-risk upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS In this single-arm phase 2 trial (NCT04672330), 20 patients with high-risk UTUC were enrolled. Eligibility criteria included high-risk UTUC (defined as high-grade UTUC confirmed by endoscopic biopsy or urinary
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The absolute volume of Gleason Pattern 4 on radical prostatectomy is more strongly associated with advanced stage and biochemical recurrence than Gleason grade groups. J. Urol. (IF 5.9) Pub Date : 2025-02-20 Simone Scuderi, Amy L Tin, Jared Klug, Shaun Porwal, Leonardo Quarta, Margherita Ciabattini, Nazario Pio Tenace, Riccardo Leni, Roberta Lucianò, Armando Stabile, Giorgio Gandaglia, James A Eastham, Francesco Montorsi, Alberto Briganti, Andrew J Vickers
ISUP Grade-Group (GG) is based on the relative proportion of Gleason patterns 3 and 4. We investigated whether absolute pattern 4 volume is more strongly associated with advanced stage and biochemical recurrence than GG in patients with pattern 4 but not 5.
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Retroperitoneal Nodal Distribution for Metastatic Seminoma: Is Modified Template Appropriate? A Retrospective Study. J. Urol. (IF 5.9) Pub Date : 2025-02-20 Jiping Zeng, Jacob McFadden, Parth Thakker, Isamu Tachibana, Timothy A Masterson, Clint Cary
Several phase II trials have investigated the efficacy of retroperitoneal lymph node dissection (RPLND) with unilateral modified template as the first-line treatment for stage II seminoma. However, the rationale for using modified templates is extrapolated from studies of non-seminomatous germ cell tumor (NSGCT). In this retrospective study, we sought to compare the oncologic outcome of bilateral and
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Prostate-Specific Antigen Density to Select Magnetic Resonance Imaging-Targeted vs Combined Biopsy for Prostate Cancer Diagnosis: A Secondary Analysis of the Trio Study. J. Urol. (IF 5.9) Pub Date : 2025-02-14 Michael Ahdoot,Aurash Naser-Tavakolian,John R Heard,Cheyenne Williams,Michael Daneshvar,Patrick Gomella,Samhita Mallavarapu,Minhaj Siddiqui,Michael Nazmifar,Joanna Shih,Baris Turkbey,Bradford Wood,Peter Pinto
PURPOSE The addition of systematic prostate biopsy enhances the detection of clinically significant prostate cancer compared with MRI-targeted biopsy alone. However, there is growing interest in using only MRI-targeted biopsy. We sought to evaluate PSA density (PSAD) as an adjunctive predictor of clinically significant prostate cancer detection in men undergoing combined biopsy and as a potential metric
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Hospital-Level Patterns of Retroperitoneal Lymph Node Dissection Surgeries: Are Recommendations for High-Volume Centralization Being Followed? J. Urol. (IF 5.9) Pub Date : 2025-02-13 Marc Ganz,Lina Posada Calderon,Richard S Matulewicz
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Gemcitabine vs Bacillus Calmette-Guérin for Intravesical Therapy in Treatment-Naïve Low-Grade Intermediate-Risk Nonmuscle-Invasive Bladder Cancer. J. Urol. (IF 5.9) Pub Date : 2025-02-10 Zine-Eddine Khene,Raj Bhanvadia,Sarah Attia,Willian Ito,Ivan Trevino,Solomon L Woldu,Vitaly Margulis,Yair Lotan
PURPOSE Patients with intermediate-risk (IR) nonmuscle-invasive bladder cancer (NMIBC) are recommended to receive induction intravesical chemotherapy or immunotherapy. However, the comparison between gemcitabine and bacillus Calmette-Guérin (BCG) in treatment-naïve patients with low-grade IR-NMIBC remains underexplored. The aim of this study was to evaluate the efficacy of gemcitabine compared with
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Adjuvant Radiation Therapy or Observation With or Without Early Salvage Radiation Therapy for Men With Node-Positive Prostate Cancer After Surgery and Negative Preoperative Conventional Imaging: A Multicenter Study. J. Urol. (IF 5.9) Pub Date : 2025-02-10 Giancarlo Marra,Francesco Barletta,Simone Scuderi,Gabriele Montefusco,Jonathan Olivier,Andres Affentranger,Josias Bastian Grogg,Thomas Hermanns,Luca Afferi,Christian Fankhauser,Agostino Mattei,Bartosz Malkiewicz,Alberto Bianchi,Alessandro Antonelli,Fabio Zattoni,Fabrizio Dal Moro,Lieke Wever,Timo F W Soeterik,Roderick C N Van Den Bergh,Pawel Rajwa,Shahrokh F Shariat,Rafael Sanchez-Salas,Lara Rodriguez-Sanchez
PURPOSE Our goals were to assess the survival outcomes of adjuvant radiation therapy (aRT) vs observation with or without early salvage radiation therapy for cN0M0 pN1 prostate cancer (PCa) and to create a model for clinical decision-making. MATERIALS AND METHODS We retrospectively identified 1103 patients with cN0M0 PCa with pN1 PCa after surgery (2000-2021) at 18 referral centers. Kaplan-Meier curves
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Is There a Winner? Prospective Randomized Controlled Trial Comparing SuperPulse Thulium Fiber Laser vs Pulse-Modulated High-Power Holmium:YAG Laser for Retrograde Intrarenal Surgery. J. Urol. (IF 5.9) Pub Date : 2025-02-07 Kavita Gupta,Anna Ricapito,Christopher Connors,Raymond Khargi,Alan J Yaghoubian,Blair Gallante,William M Atallah,Mantu Gupta
PURPOSE Pulse-modulated holmium:YAG (Ho:YAG) and SuperPulse thulium fiber laser are high-power laser systems used for retrograde intrarenal surgery. We conducted a prospective randomized trial to compare lithotripsy efficiency, complications, and stone-free rates. MATERIALS AND METHODS Patients with CT-confirmed intrarenal stones between 5 and 20 mm were randomly assigned to pulse-modulated Ho:YAG
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The High Price to Pay for Survivorship of Genitourinary Rhabdomyosarcoma, Quality of Life. J. Urol. (IF 5.9) Pub Date : 2025-02-05 Niccolo M Passoni,Jonathan C Routh
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Factors Associated With Urinary Incontinence in Nulliparous Female Elite Athletes: An Exploratory, Cross-Sectional Study Using Dynamic Pelvic Magnetic Resonance Imaging and Questionnaire Data. J. Urol. (IF 5.9) Pub Date : 2025-01-27 Zoe S Gan,Karthik Sundaram,Ariana L Smith
PURPOSE Urinary incontinence (UI) is common in nulliparous female elite athletes, but underlying pathophysiology is inadequately understood. We examined urinary symptoms and associated pelvic floor anatomy and function in this population, hypothesizing that athletes with UI would exhibit pelvic floor findings seen in older incontinent women (eg, pelvic floor descent and urethral hypermobility) and
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An Artificial Intelligence Model Using Diffusion Basis Spectrum Imaging Metrics Accurately Predicts Clinically Significant Prostate Cancer. J. Urol. (IF 5.9) Pub Date : 2025-01-27 Eric H Kim,Huaping Jing,Kainen L Utt,Joel M Vetter,R Cody Weimholt,Arnold D Bullock,Alexandra P Klim,Karla A Bergeron,Jason K Frankel,Zachary L Smith,Gerald L Andriole,Sheng-Kwei Song,Joseph E Ippolito
PURPOSE Conventional prostate magnetic resonance imaging has limited accuracy for clinically significant prostate cancer (csPCa). We performed diffusion basis spectrum imaging (DBSI) before biopsy and applied artificial intelligence models to these DBSI metrics to predict csPCa. MATERIALS AND METHODS Between February 2020 and March 2024, 241 patients underwent prostate MRI that included conventional
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Efficacy of a Clinical Decision Support Tool to Promote Guideline-Concordant Evaluations in Patients With High-Risk Microscopic Hematuria: A Cluster Randomized Quality Improvement Project. J. Urol. (IF 5.9) Pub Date : 2025-01-24 Richard S Matulewicz,Sarah Tsuruo,William C King,Arielle R Nagler,Zachary S Feuer,Adam Szerencsy,Danil V Makarov,Christina Wong,Isaac Dapkins,Leora I Horwitz,Saul Blecker
PURPOSE We aimed to determine whether implementation of a clinical decision support (CDS) tool integrated into the electronic health record of a multisite academic medical center increased the proportion of patients with AUA "high-risk" microscopic hematuria (MH) who receive guideline-concordant evaluations. MATERIALS AND METHODS We conducted a 2-arm cluster randomized quality improvement project in
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An Artificial Intelligence-Digital Pathology Algorithm Predicts Survival After Radical Prostatectomy From the Prostate, Lung, Colorectal, and Ovarian Cancer Trial. J. Urol. (IF 5.9) Pub Date : 2025-01-22 Eric V Li,Yi Ren,Jacqueline Griffin,Jialin Han,Rikiya Yamashita,Akinori Mitani,Ruoji Zhou,Huei-Chung Huang,Ximing Yang,Felix Y Feng,Andre Esteva,Hiten D Patel,Edward M Schaeffer,Lee A D Cooper,Ashley E Ross
PURPOSE Clinical variables alone have limited ability to determine which patients will have recurrence after radical prostatectomy (RP). We evaluated the ability of locked multimodal artificial intelligence (MMAI) algorithms trained on prostate biopsy specimens to predict prostate cancer-specific mortality (PCSM) and overall survival (OS) among patients undergoing RP with digitized RP specimens. MATERIALS
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Multi-Institutional Analysis of Surgery for Lichen Sclerosus-Induced Penile Urethral Stricture: Establishing Single-Stage Urethroplasty as a Primary Treatment Option. J. Urol. (IF 5.9) Pub Date : 2025-01-21 Ross Hengel,Alex Vanni,Brad Erickson,Sean Elliott,Ben Breyer,Jill C Buckley,Josh Broghammer,Bryan Voelzke,Jeremy Myers,Keith Rourke
PURPOSE Ideal treatment of lichen sclerosus (LS)-induced penile urethral strictures (PUS) remains elusive. The objective of this study was to compare multi-institutional outcomes of single-stage urethroplasty (SSU) with oral mucosal graft, staged urethroplasty, and perineal urethrostomy (PU) for treatment of LS-induced PUS. MATERIALS AND METHODS Multi-institutional analysis was performed at 9 centers
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Impact of 3D-Printed Models for Surgical Planning in Renal Cell Carcinoma With Venous Tumor Thrombus: A Randomized Multicenter Clinical Trial. J. Urol. (IF 5.9) Pub Date : 2025-01-21 I Rivero Belenchón,C B Congregado Ruíz,G Gómez Ciriza,V Gómez Dos Santos,F J Burgos Revilla,R A Medina López
PURPOSE Our goal was to determine whether surgical planning based on 3D models allows for better surgical outcomes than conventional surgical planning in (1) complications, (2) surgical time, and (3) hospital stay. MATERIALS AND METHODS This multicenter clinical trial (NCT03738488) included 66 patients diagnosed with renal cell carcinoma and venous thrombus extension who underwent nephrectomy with
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Clinical Validation of MyProstateScore 2.0 Testing Using First-Catch, Non-Digital Rectal Examination Urine. J. Urol. (IF 5.9) Pub Date : 2025-01-21 Jeffrey J Tosoian,Yuping Zhang,Jacob I Meyers,Spencer Heaton,Javed Siddiqui,Lanbo Xiao,Keavash D Assani,Daniel A Barocas,Ashley E Ross,Zoey Chopra,Grace C Herron,Jacob A Edelson,Nathan J Graham,Udit Singhal,Simpa S Salami,Todd M Morgan,Ganesh S Palapattu,John T Wei,Arul M Chinnaiyan
PURPOSE The 18-gene MyProstateScore 2.0 (MPS2) test was previously validated for detection of grade group (GG) ≥ 2 prostate cancer using post-digital rectal examination (DRE) urine. To improve ease of testing, we validated MPS2 using first-catch, non-DRE urine. MATERIALS AND METHODS Patients provided first-catch urine before biopsy. MPS2 values were calculated using previously validated models differing
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A Contemporary Estimate of Vasectomy Failure in the United States: Analysis of US Claims Data. J. Urol. (IF 5.9) Pub Date : 2024-12-31 Albert Ha,Chiyuan Amy Zhang,Shufeng Li,Ashkan Pourabhari Langroudi,Satvir Basran,Michael Scott,Frank Glover,Francesco Del Giudice,Michael L Eisenberg
PURPOSE We characterize trends in vasectomy utilization, delivery, and failure in a large administrative database. MATERIALS AND METHODS We used the Merative MarketScan (2007-2021) Commercial Database to identify vasectomized men. Vasectomy failure (VF) was defined as documented pregnancy ≥ 6 months post procedure. Additional outcomes include the need for repeat vasectomy within 1 year and birth rates
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A Tailored Electronic Survivorship Care Plan for Prostate Cancer Survivors: A Multicenter Randomized Controlled Trial. J. Urol. (IF 5.9) Pub Date : 2024-12-20 Jennifer M Jones,Andrew Matthew,Simon Tanguay,Celestia S Higano,Larry Goldenberg,Doris Howell,Manjula Maganti
PURPOSE Although the provision of a survivorship care plan (SCP) has been recommended after prostate cancer (PCa) treatment, there have been no randomized controlled trials to examine their impact. The objective of this study was to evaluate the effect of a tailored PCa-SCP intervention provided to early-stage PCa survivors. MATERIALS AND METHODS A prospective, parallel 1:1 randomized controlled trial
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Gene Therapy With URO-902 (pVAX/hSlo) for the Treatment of Female Patients With Overactive Bladder and Urge Urinary Incontinence: Safety and Efficacy From a Randomized Phase 2a Trial. J. Urol. (IF 5.9) Pub Date : 2024-12-18 Ekene A Enemchukwu,Susan Kalota,Kaiser Robertson,Sijian Ge,Jingmei Lu,Hanh Badger,Salim Mujais,Kenneth M Peters
PURPOSE We assessed efficacy and safety of URO-902, an investigational gene therapy expressing the α subunit of the large-conductance Ca2+-activated K+ channel, in a phase 2a placebo-controlled trial in women with overactive bladder (OAB). MATERIALS AND METHODS Women, age 40 to 79 years, with OAB and urge urinary incontinence who were refractory to OAB medications were randomized to single-dose URO-902
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Stimulated Raman Histology and Artificial Intelligence Provide Near Real-Time Interpretation of Radical Prostatectomy Surgical Margins. J. Urol. (IF 5.9) Pub Date : 2024-12-17 Miles P Mannas,Fang-Ming Deng,Adrian Ion-Margineanu,Christian Freudiger,Lea Lough,William Huang,James Wysock,Richard Huang,Steve Pastore,Derek Jones,Deepthi Hoskoppal,Jonathan Melamed,Daniel A Orringer,Samir S Taneja
PURPOSE Balancing surgical margins and functional outcomes is crucial during radical prostatectomy for prostate cancer. Stimulated Raman histology (SRH) is a novel, real-time imaging technique that provides histologic images of fresh, unprocessed, and unstained tissue within minutes, which can be interpreted by either humans or artificial intelligence. MATERIALS AND METHODS Twenty-two participants
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Long-Term Decision Regret and Associated Factors After Urinary Reconstruction in Underserved Patients With Spinal Cord Injury. J. Urol. (IF 5.9) Pub Date : 2024-12-17 Aidin Abedi,Luis Morales Ojeda,Stefania Montero,Nhi Ha,Priya Kohli,Petr Gaburak,Armita Abedi,David Chapman,Evgeniy Kreydin,David A Ginsberg
PURPOSE Patients with refractory neurogenic bladder dysfunction may require urinary reconstruction due to severe incontinence, difficulty with catheterization, and to prevent upper urinary tract compromise. We evaluated long-term decisional regret and associated factors after urinary reconstruction in patients with spinal cord injury. MATERIALS AND METHODS We interviewed patients with spinal cord injuries
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Perioperative Complications and Omission of Ureteral Stents During Robot-Assisted Radical Cystectomy With Intracorporeal Ileal Conduit. J. Urol. (IF 5.9) Pub Date : 2024-12-12 Jacob E Tallman,Emily A Vertosick,Syed M Alam,Fady J Baky,S Machele Donat,Eugene J Pietzak,Eugene K Cha,Timothy F Donahue,Bernard H Bochner,Andrew J Vickers,Alvin C Goh
PURPOSE Ureteral stents are commonly placed intraoperatively during radical cystectomy, although their efficacy in reducing complications is unproven. We compared clinical outcomes among patients undergoing robot-assisted radical cystectomy with intracorporeal ileal conduit (RARC-IC) with or without ureteral stents to determine if omission of ureteral stents affects postoperative complications. MATERIALS
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The Upper TRACT Endometry Score: Development and Internal Validation of an Objective Measure of Variables That Affect Endoscopic Procedures for Upper Tract Urothelial Carcinoma. J. Urol. (IF 5.9) Pub Date : 2024-12-12 Suzanne Lange,Alec Reinhardt,Daniel Igel,Craig Labbate,Mehrad Adibi,Suprateek Kundu,Surena F Matin
PURPOSE Endoscopic management (EM) is an increasingly accepted option for upper tract urothelial carcinoma (UTUC). Feasibility can be dependent on a variety of variables. The objective of this study was to identify anatomic and phenotypic tumor characteristics that affect EM, using structured expert forecasting, develop and obtain consensus on an assessment score, and perform initial validation of
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Long-Term Urinary and Sexual Outcomes in Pediatric Genitourinary Rhabdomyosarcoma Survivors: A Qualitative Study. J. Urol. (IF 5.9) Pub Date : 2024-12-12 Rachel A Saunders,Andrea K Balthazar,Christopher D Jaeger,Monah Javidan-Nejad,Candace Y Chung,Judith A Vessey,Richard S Lee,Hsin-Hsiao Scott Wang
PURPOSE Genitourinary rhabdomyosarcoma (GU-RMS) often requires multimodal therapy treatment including radiation, chemotherapy, and radical surgery for disease control. The long-term effects of the disease and associated treatments are unclear. We sought to investigate the long-term genitourinary quality of life for adult survivors of pediatric GU-RMS. MATERIALS AND METHODS In total, 14 participants