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Androgen receptor activation for breast cancer therapy Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-24 Dimple Notani
In this Journal Club, Dimple Notani discusses a study that demonstrates a tumour suppressive function of the androgen receptor in oestrogen receptor-positive breast cancer.
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Measuring HLA disruption using MHC Hammer Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-23 Clare Puttick
In this Tools of the Trade article, Clare Puttick describes the development of MHC Hammer, a computational tool that uses whole-exome sequencing and RNA sequencing data for measuring HLA disruption.
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Evolutionary paths towards metastasis Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-22 Kamila Naxerova
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CRISPR-StAR to transform in vivo functional genomic screening Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-16 Christopher Lowden
In this Tools of the Trade article, Christopher Lowden describes the development and use of CRISPR-StAR, which leverages internal controls to overcome experimental noise for improved in vivo functional genomic screens.
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Challenges of small cell lung cancer heterogeneity and phenotypic plasticity Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-10 Kathryn L. Simpson, Dominic G. Rothwell, Fiona Blackhall, Caroline Dive
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TurboCas for locus-specific proximity labelling Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-08 Bercin Cenik
In this Tools of the Trade article, Bercin Cenik describes the development and use of TurboCas, an enzyme that pairs catalytically dead Cas9 with the proximity-labelling enzyme miniTurbo to map the regulatory proteins that shape transcription.
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Blocking cholesterol biosynthesis to clean out cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-04 Daniela Senft
The mechanisms of how pH-dependent cell death, alkaliptosis, is regulated are incompletely understood. Chen et al. now demonstrate that the cholesterol biosynthesis protein CYP51A1 suppresses alkaliptosis induced by the opioid analgesic JTC801.
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Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-03 Alicia Llorente, Gurpreet K. Arora, Rabi Murad, Brooke M. Emerling
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scAtlasVAE: a deep learning framework for generating a human CD8+ T cell atlas Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-02 Ziwei Xue
In this Tools of the Trade article, Ziwei Xue describes the development and use of scAtlasVAE, a deep learning framework that integrates single-cell RNA-sequencing data from CD8+ T cells across studies.
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Salmonella, the insidious contributor to gallbladder and colon cancers Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-02 Virginie Stévenin, Jacques Neefjes
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Moonlighting functions of glucose metabolic enzymes and metabolites in cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-04-02 Dong Guo, Ying Meng, Gaoxiang Zhao, Qingang Wu, Zhimin Lu
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Sweet success in CAR T cells Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-27 Gabrielle Brewer
Glycolysis-dependent T cell function is hindered by glucose scarcity in the tumour microenvironment. Now in Cancer Cell, Schild et al. engineered T cells to utilize fructose via GLUT5, enhancing their metabolic activity and cytotoxicity.
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The fibroinflammatory response in cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-17 Zebin Xiao, Ellen Puré
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ImAge: quantifying epigenetic ageing with single-cell images Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-13 Kenta Ninomiya
In this Tools of the Trade article, Kenta Ninomiya describes the development of ImAge, an imaging-based approach that captures age-related trajectories of chromatin and epigenetic marks in single nuclei for longitudinal analyses.
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Tissue specificity of ageing in cancer risk prediction Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-13 Mark A. LaBarge, Alexandra M. Binder
Understanding the complex relationship between ageing and cancer is crucial for cancer risk prediction. Here, we explore how tissue-specific ageing biomarkers can enhance cancer risk stratification and highlight the need for tailored approaches in assessing susceptibility across different tissues. Understanding the complex relationship between ageing and cancer is crucial for cancer risk prediction
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Fighting cancer with fat Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-11 Gabrielle Brewer
Targeting metabolic dependencies, such as glucose or lipid metabolism, is a key strategy for anti-cancer therapies. Nguyen et al. developed a new approach, adipose manipulation transplantation (AMT), in which engineered adipocytes are used to outcompete tumours for lipids and glucose to suppress cancer progression.
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When tumour cells get excited Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-07 Daniela Senft
A recent study published in Nature finds that neuroendocrine small-cell lung cancer (SCLC) cells exhibit electrical activity that directly drives tumour progression and metastasis and shows that they rely on oxidative phosphorylation to meet the high energy demand associated with these electrophysiological processes.
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ALK in cancer: from function to therapeutic targeting Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-07 Claudia Voena, Chiara Ambrogio, Fabio Iannelli, Roberto Chiarle
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PROTACing against liver cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-05 Anna Dart
Yang et al. developed a proteolysis-targeting chimera (PROTAC) 753b, which targets BCL-xL and BCL-2 to the E3 ubiquitin ligase VHL, and showed that it removed senescent cells specifically from the liver, reducing the progression of chronic metabolic liver disease to liver cancer.
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A machine learning toolkit for subtyping cancer in existing and new datasets Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-05 Jordan Lee
In this Tools of the Trade article, Jordan Lee describes the development and use of the Tumor Molecular Pathology (TMP) toolkit, a cancer subtyping tool that can assign TCGA molecular subtypes to new, independent non-TCGA datasets.
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We cannot ignore the cancer risks of wildfires Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-05 Scott Weichenthal
Wildfires release a range of known human carcinogens and tend to occur in the same regions each year. As a result, long-term exposures to wildfire pollutants are a concern and will probably increase cancer risk in exposed populations. Actionable solutions are available to reduce exposures and mitigate these risks. Wildfires emit carcinogenic pollutants, raising long-term cancer risks in affected populations
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Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-03-04 Daniel C. Bruhm, Nicholas A. Vulpescu, Zachariah H. Foda, Jillian Phallen, Robert B. Scharpf, Victor E. Velculescu
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Cancer treatments accelerate ageing Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-02-27 Marco Demaria
Advancements in cancer treatment have led to a growing population of cancer survivors worldwide, who often experience premature onset of age-related conditions. Understanding the molecular and cellular basis of the long-term consequences of cancer treatment is essential for developing interventions to mitigate their adverse effects. While cancer treatments are essential for patient survival, they often
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Detecting somatic mutations in single-cell data with SComatic Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-02-25 Tim H. H. Coorens
In this Tool of the Trade article, Tim Coorens describes the development of SComatic, an algorithm enabling the detection of somatic mutations in single-cell RNA- or ATAC-sequencing data, and its use to study lineage relations and mutational signatures.
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Translating premalignant biology to accelerate non-small-cell lung cancer interception Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-02-24 Sarah A. Mazzilli, Zahraa Rahal, Maral J. Rouhani, Sam M. Janes, Humam Kadara, Steven M. Dubinett, Avrum E. Spira
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Defining a ‘cells to society’ research framework for appendiceal tumours Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-02-20 Andreana N. Holowatyj, Michael J. Overman, Konstantinos I. Votanopoulos, Andrew M. Lowy, Patrick Wagner, Mary K. Washington, Cathy Eng, Wai Chin Foo, Richard M. Goldberg, Mojgan Hosseini, Kamran Idrees, Douglas B. Johnson, Ardaman Shergill, Erin Ward, Nicholas C. Zachos, Deborah Shelton
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Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-02-19 Constantinos Harkos, Andreas G. Hadjigeorgiou, Chrysovalantis Voutouri, Ashwin S. Kumar, Triantafyllos Stylianopoulos, Rakesh K. Jain
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Dendritic cell maturation in cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-02-07 Chang Yoon Moon, Meriem Belabed, Matthew D. Park, Raphaël Mattiuz, Daniel Puleston, Miriam Merad
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Maximizing the dual benefit of pet dogs in cancer trials Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-31 Jennifer A. Lenz, Matthew J. Atherton
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Small speckles, big impact Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-31 Daniela Senft
In this study, Alexander et al. find that HIF2α regulates speckle–DNA associations to fine-tune the expression of a subset of its target genes, and demonstrate that speckle phenotypes correlate with outcomes in renal cell carcinoma.
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Allies in the epidermis Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-30 Gabrielle Brewer
Immunosuppression disrupts normal skin homeostasis, raising the risk of cancer development. Now, Son et al. find that commensal papillomavirus maintains homeostasis in sun-damaged skin.
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Cross-priming in cancer immunology and immunotherapy Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-29 Carlos Luri-Rey, Álvaro Teijeira, Stefanie K. Wculek, Carlos de Andrea, Claudia Herrero, Alvaro Lopez-Janeiro, María E. Rodríguez-Ruiz, Ignacio Heras, Maria Aggelakopoulou, Pedro Berraondo, David Sancho, Ignacio Melero
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Tumour hypoxia in driving genomic instability and tumour evolution Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-28 Alexandru Suvac, Jack Ashton, Robert G. Bristow
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Metabolic interplays between the tumour and the host shape the tumour macroenvironment Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-20 Patricia Altea-Manzano, Amanda Decker-Farrell, Tobias Janowitz, Ayelet Erez
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Rusting away with age Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-14 Gabrielle Brewer
In a recent study published in Nature, Zhuang et al. outline how ageing affects stemness and tumorigenic potential of tumour-initiating alveolar stem cells in the lung.
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Decoding the functional impact of the cancer genome through protein–protein interactions Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-14 Haian Fu, Xiulei Mo, Andrey A. Ivanov
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Fructose takes a detour to feed cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2025-01-08 Daniela Senft
The mechanisms by which dietary fructose promotes tumour progression have remained poorly understood. A recent study published in Nature reveals that dietary fructose is metabolized in the liver, resulting in elevated circulating lipid levels that can serve as building blocks for cancer cells outside the liver.
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Conventional chemotherapy: millions of cures, unresolved therapeutic index Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-12-16 Anthony Letai, Hugues de The
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PDX models for functional precision oncology and discovery science Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-12-16 Zannel Blanchard, Elisabeth A. Brown, Arevik Ghazaryan, Alana L. Welm
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Nanotubes power up T cells Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-12-03 Gabrielle Brewer
Intercellular mitochondrial transfer via tunnelling nanotubes can influence cellular bioenergetics and function in tumours. A study in Cell demonstrates how this process can increase CD8+ T cell metabolic fitness and anti-tumour function.
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Lactate gives a sour taste Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-12-03 Daniela Senft
Wang et al. demonstrate that lactate derived from glioblastoma stem cells, microglia and macrophages drives histone lactylation, activating immunosuppressive transcriptional programs and upregulating CD47, to suppress phagocytosis.
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Re-envisioning genetic predisposition to childhood and adolescent cancers Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-12-03 Christian P. Kratz
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Identifying memory genes in cancer drug tolerance Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-12-02 Shaon Chakrabarti
In this Journal Club, Chakrabarti discusses a method to dissect the molecular architecture of inheritable gene expression (memory) states that mark cells that transition into drug-tolerant persister cells in melanoma.
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Androgen receptor signalling in non-prostatic malignancies: challenges and opportunities Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-11-25 G. Paolo Dotto, An Buckinx, Berna C. Özdemir, Christian Simon
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Chromothripsis in cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-11-15 Milena Simovic-Lorenz, Aurélie Ernst
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Dedicated centres and multinational platforms to improve patient care and address early-onset cancers Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-11-11 Irit Ben-Aharon, Elizabeth Smyth, Anna D. Wagner
The incidence of early-onset cancers has increased by approximately 80% over the past three decades. These patients have unique needs. For optimal care, designated OncoYoung programs should be created. In addition, multinational platforms with dedicated funding are necessary to investigate the aetiology of early-onset cancers and develop preventive measures. In this Comment, Ben-Aharon et al. advocate
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Genetic and epigenetic bases of long-term adverse effects of childhood cancer therapy Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-11-07 Zhaoming Wang, Jinghui Zhang
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Fanconi anaemia pathway induces chromosome shattering Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-11-06 Gabrielle Brewer
Engel et al. conducted a genetic screen in which they identified the Fanconi anaemia (FA) pathway as a driver of chromothripsis, complex genomic rearrangements and generation of extrachromosomal DNA.
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Developing multiple EGFR-mutant lung cancers Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-11-06 Daniela Senft
The occurrence of multiple independent tumours in patients with EGFR-mutant lung cancer was unexplained. A recent study in Nature Cancer identified distinct genetic predisposition mechanisms, including developmental mosaicism and germline EGFR variants, that contribute to the formation of multiple primary tumours.
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Author Correction: The importance of 3D fibre architecture in cancer and implications for biomaterial model design Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-11-04 Jennifer C. Ashworth, Thomas R. Cox
Correction to: Nature Reviews Cancer https://doi.org/10.1038/s41568-024-00704-8, published online 17 June 2024.
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Characterization of the B cell receptor repertoire in melanoma Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-11-04 Jisu Chae, Junho Chung
In this Journal Club, Chae and Chung discuss a study characterizing the differentiation and maturation of both tumour-resident and circulating B cells in patients with melanoma.
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Midkine crisis fuels age-related tumorigenesis Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-31 Gabrielle Brewer
Ageing is a well-accepted risk factor for developing cancer. Yan et al. used a preclinical rat model to study the mechanisms facilitating the age-associated increase in breast tumorigenesis.
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The present and future of the Cancer Dependency Map Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-28 Rand Arafeh, Tsukasa Shibue, Joshua M. Dempster, William C. Hahn, Francisca Vazquez
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Stemness in solid malignancies: coping with immune attack Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-25 Judith Agudo, Yuxuan Miao
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Convergent inducers and effectors of T cell paralysis in the tumour microenvironment Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-24 Douglas Hanahan, Olivier Michielin, Mikael J. Pittet
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High-resolution measurement of individual telomere lengths with Telo-seq Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-22 Carly Tyer
In this Tools of the Trade article, Carly Tyer describes the development of Telo-seq, a method to enrich and sequence all telomeres within a sample, and highlights its use in distinguishing between the two telomere maintenance mechanisms used in cancer cells.
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Emerging strategies to investigate the biology of early cancer Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-21 Ran Zhou, Xiwen Tang, Yuan Wang
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Epigenomic heterogeneity as a source of tumour evolution Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-16 Marthe Laisné, Mathieu Lupien, Céline Vallot
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New horizons in our understanding of precursor multiple myeloma and early interception Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-16 David M. Cordas dos Santos, Rosa Toenges, Luca Bertamini, Jean-Baptiste Alberge, Irene M. Ghobrial
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Immunoproteasome as a biomarker for immunotherapy Nat. Rev. Cancer (IF 72.5) Pub Date : 2024-10-15 Radhakrishnan Sabarinathan
In this Journal Club, Sabarinathan discusses a study suggesting immunoproteasome expression as a potential biomarker of response to immune checkpoint inhibition in melanoma.