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Eph receptors and ephrins in cancer progression Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-11-23 Elena B. Pasquale
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Understanding and addressing race disparities in childhood cancer outcomes Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-11-20 M. Monica Gramatges
Vulnerable populations remain disproportionately at risk for inferior childhood cancer outcomes. Here, I outline the scope and magnitude of childhood cancer disparities worldwide and suggest multi-level clinical care and research opportunities to address cancer health inequities. Although childhood cancer survival rates have increased globally, there is a markedly inequitable distribution of these
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Translating tumour immunity control Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-11-15 Glaucia N. M. Hajj
In this Journal Club, Hajj discusses a study demonstrating that oncogene activation modulates immune control through both transcription and translation.
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Inflammatory neutrophils Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-11-09 Daniela Senft
Maas et al. identify an inflammatory, immunosuppressive phenotype in neutrophils that accumulates in brain malignancies, and show that this tumour-promoting neutrophil activation is driven by the brain tumour microenvironment.
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Targeting the tumour’s little helpers Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-11-09 Linda Gummlich
Wang et al. show that antibiotic targeting of anaerobic intratumoral bacteria exposes a unique repertoire of microbial neoantigens that can successfully trigger cellular immunity against colorectal cancer in mice.
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Deubiquitinases in cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-11-07 Grant Dewson, Pieter J. A. Eichhorn, David Komander
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Metabolic pathway analysis using stable isotopes in patients with cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-10-31 Caroline R. Bartman, Brandon Faubert, Joshua D. Rabinowitz, Ralph J. DeBerardinis
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How protons pave the way to aggressive cancers Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-10-26 Pawel Swietach, Ebbe Boedtkjer, Stine Falsig Pedersen
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wildDISCO: HD whole-body imaging Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-10-23 Hongcheng Mai
In this Tools of the Trade article, Hongcheng Mai describes the development of wildDISCO, an approach for whole-body immunolabelling, optical clearing and imaging in mice.
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The microbiome as a determinant of racial and ethnic cancer disparities Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-10-23 Doratha Byrd, Patricia Wolf
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Advances in translational research of the rare cancer type adrenocortical carcinoma Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-10-19 Chandrayee Ghosh, Jiangnan Hu, Electron Kebebew
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Breast milk for breast cancer detection Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-10-17 Gabrielle Brewer
Pregnancy-associated breast cancers are typically diagnosed at more advanced stages than other breast cancers. Recently, Saura et al. developed a non-invasive screening method using breast milk to diagnose patients prior to tumour detection by imaging.
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Stem-like exhausted and memory CD8+ T cells in cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-10-11 Thomas Gebhardt, Simone L. Park, Ian A. Parish
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Transfer RNAs as dynamic and critical regulators of cancer progression Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-10-09 Alexandra M. Pinzaru, Sohail F. Tavazoie
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Prime editing GEMMs to model cancer mutations Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-28 Nicolas Mathey-Andrews
In this Tool of the Trade article, Nicolas Mathey-Andrews describes the generation and use of a prime editor mouse that enables in vivo modelling of the multitude of cancer alleles found in human tumours.
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Tertiary lymphoid structures as hubs of antitumour immunity Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-27 Gabriela Sarti Kinker, Tiago da Silva Medina
In this Journal Club, Kinker & Medina discuss a study showing the role of tumour-associated tertiary lymphoid structures in improving immunotherapy response and overall survival in patients with melanoma.
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Computing brain metastasis impact Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-27 Daniela Senft
In a recent study, Sanchez-Aguilera, Masmudi-Martín et al. find that a molecular program explains the cognitive impairment often seen in patients with brain metastasis, challenging the prevailing paradigm of the tumour mass being the sole cause of altered brain function.
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Enhanced transposable elements Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-27 Gabrielle Brewer
Karttunen et al. identify the contribution of transposable elements to gene regulatory function in colorectal and liver cancer cell lines.
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Synaptic activity promotes melanoma formation Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-27 Daniela Senft
In a recent study, Tagore et al. find that the formation of synapse-like structures that serve to transfer GABA between premalignant melanocytes and keratinocytes promotes melanoma initiation by the BRAFV600E oncogene.
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Harnessing the influenza virus to fight cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-25 Dezhong Ji
In this Tools of the Trade article, Dezhong Ji describes the development and use of a chimeric antigenic peptide influenza virus (CAP-Flu) system as a cancer vaccine strategy to promote tumour-infiltrating T cell activation in lung metastasis.
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Research does not happen in a socio-political vacuum — we should not pretend that it does Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-18 Eric K. Lau
On the basis of personal experiences and in light of current US socio-political realities, Eric Lau advocates for proactive actions against discrimination and emphasizes the need to speak out against oppression, urging research institutions to prioritize diversity, equity and inclusion.
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Advances in the structure, mechanism and targeting of chemoresistance-linked ABC transporters Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-15 Andaleeb Sajid, Hadiar Rahman, Suresh V. Ambudkar
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Identification of personalized cancer neoantigens with HANSolo Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-13 Chiara Maria Cattaneo
In this Tools of the Trade article, Chiara Cattaneo describes the development of HANSolo, a high-throughput genetic platform for the personalized identification of CD4+ and CD8+ T cell-recognized (neo)antigens, that can be used to generate patient-specific TCR gene therapies or cancer vaccines.
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Bridging live-cell imaging and next-generation cancer treatment Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-13 Maria Alieva, Amber K. L. Wezenaar, Ellen J. Wehrens, Anne C. Rios
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Patient-derived iPSCs to study blood cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-12 Emmanuel Olivier
In this Tools of the Trade article, Emmanuel Olivier describes an approach to reprogramming AML cancer cells into induced pluripotent stem cells, which provide faithful genetic models of the most common genetic subgroups of AML.
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Maximize your research impact with storytelling Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-11 Julia R. Bauman
An often undervalued skill in science, storytelling is a powerful tool for communicating research to diverse audiences. As scientists, we ought to focus on crafting the narrative of our work: it can effectively convey knowledge to the research community, disseminate findings to lay audiences and help us clarify our own thinking about projects. Although sometimes overlooked, storytelling is a powerful
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Targeting sex steroid biosynthesis for breast and prostate cancer therapy Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-08 Matti Poutanen, Malin Hagberg Thulin, Pirkko Härkönen
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Epigenetic lesions drive gliomagenesis Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-05 Gabrielle Brewer
Rahme et al. establish an in vivo model for low-grade glioma, and use it to demonstrate that Pdgfra insulator loss and Cdkn2a promoter silencing are epigenetic drivers of gliomagenesis.
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METTL3 inhibition enhances anti-tumour immunity Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-05 Gabrielle Brewer
In this study, Guirguis et al. show mechanistically how preventing m6A RNA modification through inhibition of METTL3 can promote anti-tumour immunity.
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Targeting aberrant splicing Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-09-04 Anna Dart
Bland et al. show that cancer types with heterozygous somatic hotspot mutations in the spliceosome component SF3B1 are vulnerable to PARP inhibition, which causes a defective response to replication stress.
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AT1 cells appear centre stage Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-08-30 Daniela Senft
Two independent studies published together in Nature find that AT1 cells can have a role in both the initiation and suppression of lung adenocarcinoma.
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ARPLA for spatial imaging of glycoRNAs Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-08-29 Yuan Ma
In this Tools of the Trade article, Yuan Ma describes the development and use of ARPLA, a spatial imaging tool that can be used to visualize glycoRNAs in single cells, including cancer cells in situ.
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The circ du RNA Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-08-09 Gabrielle Brewer
In this study, Conn et al. functionally link circular RNA and DNA interactions with chromosomal translocation in leukaemogenesis.
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Long-range gene regulation in hormone-dependent cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-08-03 Theophilus T. Tettey, Lorenzo Rinaldi, Gordon L. Hager
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Addicted to extra chromosomes Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-31 Anna Dart
Girish et al. designed a method to genetically remove extra chromosomes from human aneuploid cancer cells to show that they are important for malignant growth and not just a bystander.
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Therapeutic resistance to anti-oestrogen therapy in breast cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-27 Marie Will, Jackson Liang, Ciara Metcalfe, Sarat Chandarlapaty
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FSP1 in cancer: not just a phase Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-25 Gabrielle Brewer
Inducing ferroptosis in cancer cells has become a realistic method for promoting cancer cell death. In this study, Nakarmua et al. identify a novel ferroptosis suppressor 1 (FSP1) inhibitor that promotes FSP1 relocalization through phase separation, priming ferroptosis and ultimately impairing tumour growth.
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Cancers make their own luck: theories of cancer origins Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-24 Amir Jassim, Eric P. Rahrmann, Ben D. Simons, Richard J. Gilbertson
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Polygenic scores in cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-21 Xin Yang, Siddhartha Kar, Antonis C. Antoniou, Paul D. P. Pharoah
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Lessons in gastric adenocarcinoma from TCGA Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-20 Tiago Cordeiro Felismino, Felipe José Fernández Coimbra
In this Journal Club, Felismino and Coimbra discuss the impact of TCGA’s comprehensive molecular characterization of gastric adenocarcinoma.
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Pathogenesis of cancers derived from thyroid follicular cells Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-12 James A. Fagin, Gnana P. Krishnamoorthy, Iñigo Landa
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The Y chromosome as a risk factor Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-06 Anna Dart
Two independent studies published in Nature have collectively addressed the long-standing question of sex bias in cancer and implicated non-hormonal genes of the Y chromosome in aggressive features of colorectal and bladder cancers in men.
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Bacteria in cancer initiation, promotion and progression Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-07-03 Geniver El Tekle, Wendy S. Garrett
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Feeding latent brain metastasis Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-27 Daniela Senft
In this study, Malladi and colleagues reveal the mechanism by which mitochondrial fragmentation enables latent brain metastatic breast cancer cells to increase fatty acid oxidation to maintain cellular energetics and redox homeostasis.
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Micro-engineering and nano-engineering approaches to investigate tumour ecosystems Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-23 Mijin Kim, Magdalini Panagiotakopoulou, Chen Chen, Stephen B. Ruiz, Karuna Ganesh, Tuomas Tammela, Daniel A. Heller
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Understanding tumour endothelial cell heterogeneity and function from single-cell omics Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-22 Qun Zeng, Mira Mousa, Aisha Shigna Nadukkandy, Lies Franssens, Halima Alnaqbi, Fatima Yousif Alshamsi, Habiba Al Safar, Peter Carmeliet
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Proximity labelling to study chromatin interactomes Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-15 Ciaran P. Seath
In this Tools of the Trade article, Ciaran Seath describes the development and use of a proximity labelling method to study how cancer driving mutations and small molecule ligands remodel the chromatin microenvironment.
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Tumour EVPs disrupt liver function Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-15 Gabrielle Brewer
Wang et al. demonstrate how tumour-derived extracellular vesicles and particles dysregulate liver function to promote fatty liver disease and diminish chemotherapeutic efficacy.
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mRNA-based cancer therapeutics Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-13 Chuang Liu, Qiangqiang Shi, Xiangang Huang, Seyoung Koo, Na Kong, Wei Tao
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Insights into recent findings and clinical application of YAP and TAZ in cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-12 J. Matthew Franklin, Zhengming Wu, Kun-Liang Guan
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Deciphering the cancer genome and epigenome Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-07 Isabel Esain-Garcia
In this Tools of the Trade article, Isabel Esain-Garcia describes the development and use of a 6-letter whole-genome sequencing technology, which enables the simultaneous acquisition of genetic and epigenetic information from human genomic and cell-free DNA, which has implications for improving our biological understanding of cancer as well as cancer diagnosis and early intervention.
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Advances in cutaneous squamous cell carcinoma Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-07 Mårten C. G. Winge, Laura N. Kellman, Konnie Guo, Jean Y. Tang, Susan M. Swetter, Sumaira Z. Aasi, Kavita Y. Sarin, Anne Lynn S. Chang, Paul A. Khavari
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Glioblastomas remodel neural circuits Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-06 Isobel Leake
Krishna et al. investigated the potential mechanisms by which glioblastomas remodel neural circuits.
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Gut microbiome immaturity and childhood acute lymphoblastic leukaemia Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-06 Ioannis Peppas, Anthony M. Ford, Caroline L. Furness, Mel F. Greaves
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Defining and using immune archetypes to classify and treat cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-05 Alexis J. Combes, Bushra Samad, Matthew F. Krummel
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Traject3d for studying 3D cellular heterogeneity Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-06-02 Eva C. Freckmann
In this Tool of the Trade article, Eva Freckmann describes the development of Traject3d, a workflow that enables the detection of heterogeneous phenotypes in 3D culture by analysing label-free multi-day time-lapse imaging.
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Advances in PET imaging of cancer Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-05-31 Johannes Schwenck, Dominik Sonanini, Jonathan M. Cotton, Hans-Georg Rammensee, Christian la Fougère, Lars Zender, Bernd J. Pichler
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Impaired RNA clearance Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-05-25 Gabrielle Brewer
In this study, Insco et al. find patient-specific CDK13 mutations to impede RNA surveillance, leading to the accumulation and translation of prematurely terminated RNAs that drive malignancy in melanoma models.
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Endocytosis in cancer and cancer therapy Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-05-22 Blerida Banushi, Shannon R. Joseph, Benedict Lum, Jason J. Lee, Fiona Simpson
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Nerve-driven metastasis Nat. Rev. Cancer (IF 78.5) Pub Date : 2023-05-17 Daniela Senft
Sloan and colleagues demonstrate that anthracycline chemotherapy drives metastatic progression by stimulating a cancer cell-mediated increase in nerve fibre activity in the tumour microenvironment, which can be reversed by the use of β-blockers.