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The relationship between shrunken pore syndrome and all-cause mortality in people with type 2 diabetes and normal renal function: the Fremantle Diabetes Study Phase II Diabetol. (IF 8.4) Pub Date : 2025-04-21 David G. Bruce, Wendy A. Davis, S. A. Paul Chubb, Timothy M. E. Davis
Aims/hypothesis Estimated GFRs utilising creatinine- (eGFRcreat) or cystatin C-based (eGFRcyst) equations can generate discrepant results that are associated with clinical outcomes. A low eGFRcyst/eGFRcreat ratio (<0.60), reflecting a pathological glomerular state termed shrunken pore syndrome (SPS), has been associated with excess mortality in some clinical situations including diabetes. The aim of
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Diabetes and natural and man-made disasters: prevention, preparation, response and recovery Diabetol. (IF 8.4) Pub Date : 2025-04-15 Andrew J. M. Boulton, Alicia J. Jenkins, Brij Makkar, Boris Mankovsky, Merhawit A. Abera, Solomon Tesfaye
Both the global prevalence of diabetes and the frequency of natural and man-made disasters are increasing. Of all chronic diseases, the consequences of sudden loss of medical supplies are most serious for those with diabetes, with people living with type 1 diabetes being at risk of death within a few days without insulin. This review considers how to prepare for and respond to sudden reductions in
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Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis Diabetol. (IF 8.4) Pub Date : 2025-04-12 José Maria Costa-Junior, Alexandra Coomans de Brachène, Anyïshai E. Musuaya, Priscila L. Zimath, Eugenia Martin-Vazquez, Junior G. Oliveira, Julie Carpentier, Vitalie Faoro, Malgorzata Klass, Miriam Cnop, Decio L. Eizirik
Aims/hypothesis Inflammation-driven pancreatic beta cell death is a hallmark of type 1 diabetes progression. We have previously shown that serum obtained from individuals after high-intensity interval training prevents cytokine-induced human beta cell apoptosis, but the mediators of this beneficial effect remain to be characterised. In this study we evaluated the role of exercise-induced meteorin-like
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The genetic architecture of type 1 diabetes over time: how well can we rely on past data to predict the future? Diabetol. (IF 8.4) Pub Date : 2025-04-12 Jose Zapardiel-Gonzalo,Anette-Gabriele Ziegler,Ezio Bonifacio
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Metabolic effects of 3-hydroxybutyrate infusion in individuals with type 1 diabetes compared with healthy control participants: a randomised crossover trial showing intact feedback suppression of lipolysis Diabetol. (IF 8.4) Pub Date : 2025-04-10 Maj Bangshaab, Mads V. Svart, Nikolaj Rittig, Mette G. B. Pedersen, Jens Voigt, Niels Jessen, Niels Møller
Aims/hypothesis Diabetic ketoacidosis remains a severe complication in type 1 diabetes, arising from insufficient insulin levels and accelerated lipolytic rate, leading to increased β-oxidation of NEFA and ketone body production in the liver. The ketone body 3-hydroxybutyrate (3-OHB) inhibits lipolysis in healthy individuals. The current study aimed to test whether this feedback suppression of lipolysis
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The genetics of low and high birthweight and their relationship with cardiometabolic disease Diabetol. (IF 8.4) Pub Date : 2025-04-10 Gunn-Helen Moen, Liang-Dar Hwang, Caroline Brito Nunes, Nicole M. Warrington, David M. Evans
Aims/hypothesis Low birthweight infants are at increased risk not only of mortality, but also of type 2 diabetes mellitus and CVD in later life. At the opposite end of the spectrum, high birthweight infants have increased risk of birth complications, such as shoulder dystocia, neonatal hypoglycaemia and obesity, and similarly increased risk of type 2 diabetes mellitus and CVD. However, previous genome-wide
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Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with APOE-ε4 Diabetol. (IF 8.4) Pub Date : 2025-04-11 Martin Schain, Edvin Johansson, Iina Laitinen, Anna Frödén Löwenmark, Mark Lubberink, Anders Gummesson, Torsten Danfors, Pirjo Nuutila, Russell Esterline, Lars Johansson, Jan Oscarsson, Kerstin Heurling
Aims/hypothesis Epidemiological studies indicate that type 2 diabetes increases the risk for Alzheimer’s disease. Alterations in cerebral metabolism have been proposed as a potential mechanism underlying this association. A better understanding of these metabolic changes may elucidate potential pathways linking type 2 diabetes to Alzheimer’s disease. The aim of the current exploratory study was to
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Cardiac remodelling, recognition memory deficits and accelerated ageing in a rat model of gestational diabetes Diabetol. (IF 8.4) Pub Date : 2025-04-05 Sathya Velmurugan, Vivek K. Pandey, Nirmal Verma, Deepak Kotiya, Florin Despa, Sanda Despa
Aims/hypothesis Women with prior gestational diabetes mellitus (GDM) have higher incidence of age-associated diseases, including type 2 diabetes, CVD and cognitive impairment. Human studies cannot readily determine whether GDM causes these conditions or the underlying mechanisms. Here we used a well-validated rat model of GDM to address these questions. Methods Rats with beta cell-specific expression
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Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities Diabetol. (IF 8.4) Pub Date : 2025-04-05 Rashmi B. Prasad, Liisa Hakaste, Tiinamaija Tuomi
Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestation and disease progression, with the only common feature being chronic hyperglycaemia. In spite of vigorous efforts to elucidate the pathogenetic origins and natural course of the disease, there is still a lack of biomarkers and tools for prevention, disease stratification and treatment
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The effect of once-weekly insulin icodec vs once-daily basal insulin on physical activity-attributed hypoglycaemia in type 2 diabetes: a post hoc analysis of ONWARDS 1–5 Diabetol. (IF 8.4) Pub Date : 2025-04-05 Michael C. Riddell, Simon Heller, Lisbeth Carstensen, Thaís M. Pagliaro Rocha, Sara Kehlet Watt, Vincent C. Woo
Aims/hypothesis Physical activity increases the risk of hypoglycaemia in individuals with type 2 diabetes when basal or basal-bolus insulin therapy is administered. Once-weekly basal insulins may elevate the risk of physical activity-attributed hypoglycaemia compared with other basal insulins because the administered levels cannot be reduced in anticipation of increased physical activity. This post
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Parent-of-origin effects in the life-course evolution of cardiometabolic traits Diabetol. (IF 8.4) Pub Date : 2025-04-02 Rucha Wagh, Gad Hatem, Jonas Andersson, Pooja Kunte, Souvik Bandyopadhyay, Chittaranjan S. Yajnik, Rashmi B. Prasad
Aims/hypothesis Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance from one parent or parental bias. Most studies of these phenomena have focused on adult populations. We aimed to investigate the heritability and parent-of-origin effects on cardiometabolic traits in a birth cohort with serial measurements to determine whether these
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Macular perfusion alterations in people with recent-onset diabetes and novel diabetes subtypes Diabetol. (IF 8.4) Pub Date : 2025-03-31 Sema Kaya, Ala Khamees, Gerd Geerling, Piotr Strzalkowski, Veronika Gontscharuk, Julia Szendroedi, Karsten Müssig, Dan Ziegler, Michael Roden, Rainer Guthoff
Aims/hypothesis Our aim was to detect early structural and functional changes in the macular capillaries using optical coherence tomography angiography during the course of type 1 or 2 diabetes mellitus. Methods In this cross-sectional study, individuals with type 1 diabetes (n=143) or type 2 diabetes (n=197) from the German Diabetes Study (ClinicalTrials.gov registration no. NCT01055093) underwent
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HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes Diabetol. (IF 8.4) Pub Date : 2025-03-29 Magdalene K. Montgomery, Sihan Lin, Chieh-Hsin Yang, Krishneel Prasad, Zhi Li Cheng, Jacqueline Bayliss, Michael G. Leeming, Nicholas A. Williamson, Kim Loh, Li Dong, Matthew J. Watt
Aims/hypothesis Type 2 diabetes is a chronic metabolic disorder characterised by insulin resistance and sustained hyperglycaemia, and is a major cause of blindness, kidney failure, heart attacks and stroke. Our team has recently identified hexosaminidase A (HEXA) as an endocrine factor secreted by the liver that regulates sphingolipid metabolism in skeletal muscle. Specifically, HEXA converts GM2 to
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TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion Diabetol. (IF 8.4) Pub Date : 2025-03-26 Xiong Liu, Theodore dos Santos, Aliya F. Spigelman, Shawn Duckett, Nancy Smith, Kunimasa Suzuki, Patrick E. MacDonald
Aims/hypothesis Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying mechanisms regulating glucagon secretion and alpha cell dysfunction remain unclear. While insulin secretion from pancreatic beta cells has long been known to be controlled partly by intracellular phospholipid signalling, very little is known about the role of phospholipids
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Immunotherapy with low-dose IL-2 attenuates vascular injury in mice with diabetic and neovascular retinopathy by restoring the balance between Foxp3+ Tregs and CD8+ T cells Diabetol. (IF 8.4) Pub Date : 2025-03-25 Devy Deliyanti, Varaporn Suphapimol, Amit Joglekar, Abhirup Jayasimhan, Jennifer L. Wilkinson-Berka
Aims/hypothesis Diabetic retinopathy features damage to the retinal microvasculature that causes vessels to leak and proliferate and can lead to vision loss and blindness. Inflammation contributes to the development of diabetic retinopathy, but little is known about the role of the adaptive immune system, including the benefits of augmenting the Forkhead box protein P3 (Foxp3) regulatory T cell (Treg)
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Regulating islet stress responses through CD47 activation Diabetol. (IF 8.4) Pub Date : 2025-03-25 Atharva Kale, Mahmoud Azar, Vanessa Cheng, Harry Robertson, Sally Coulter, Paulomi M. Mehta, Sohel M. Julovi, Ellis Patrick, Kedar Ghimire, Natasha M. Rogers
Aims/hypothesis Diabetes is a global health burden characterised by incremental beta cell loss. Islet transplantation is a recognised treatment for individuals with type 1 diabetes and hypoglycaemia unawareness but broader application is constrained by limited islet survival and function post-transplantation. The underlying molecular mechanisms that induce beta cell dysfunction and demise remain unclear
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Quinine: rediscovery of an old glucose-lowering drug. Diabetol. (IF 8.4) Pub Date : 2025-03-25 Jean-Claude Henquin
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Quinine: rediscovery of an old glucose-lowering drug. Reply to Henquin J-C [letter]. Diabetol. (IF 8.4) Pub Date : 2025-03-25 Javad Anjom-Shoae,Michael Horowitz,Christine Feinle-Bisset
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Early weight loss, diabetes remission and long-term trajectory after diagnosis of type 2 diabetes: a retrospective study Diabetol. (IF 8.4) Pub Date : 2025-03-22 Mario Luca Morieri, Mauro Rigato, Vera Frison, Michele D’Ambrosio, Giovanni Sartore, Angelo Avogaro, Gian Paolo Fadini
Aims/hypothesis Weight loss can improve glycaemic management in individuals with type 2 diabetes, but its long-term effects on remission, cardiovascular risk factors and complications remain unclear. We investigated clinical outcomes following non-interventional ≥10% body weight loss in people with newly diagnosed type 2 diabetes in a routine care setting. Methods We retrospectively analysed two cohorts
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Comprehensive sequencing profile and functional analysis of IsomiRs in human pancreatic islets and beta cells Diabetol. (IF 8.4) Pub Date : 2025-03-18 Stefano Auddino, Elena Aiello, Giuseppina E. Grieco, Daniela Fignani, Giada Licata, Marco Bruttini, Alessia Mori, Andrea F. Berteramo, Erika Pedace, Laura Nigi, Caterina Formichi, Claudiane Guay, Giuseppe Quero, Vincenzo Tondolo, Gianfranco Di Giuseppe, Laura Soldovieri, Gea Ciccarelli, Andrea Mari, Andrea Giaccari, Teresa Mezza, Agnese Po, Romano Regazzi, Francesco Dotta, Guido Sebastiani
Aims/hypothesis MiRNAs regulate gene expression, influencing beta cell function and pathways. Isoforms of miRNA (isomiRs), sequence variants of miRNAs with post-transcriptional modifications, exhibit cell-type-specific expression and functions. Despite their biological significance, a comprehensive isomiR profile in human pancreatic islets and beta cells remains unexplored. This study aims to profile
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The efficacy of islet autoantibody screening with or without genetic pre-screening strategies for the identification of presymptomatic type 1 diabetes Diabetol. (IF 8.4) Pub Date : 2025-03-19 Ezio Bonifacio, Raquel Coelho, Domenik A. Ewald, Gita Gemulla, Michael Hubmann, Przemyslawa Jarosz-Chobot, Mirjam Kohls, Olga Kordonouri, Vito Lampasona, Parth Narendran, Flemming Pociot, Zdenek Šumník, Agnieszka Szypowska, Jose Zapardiel-Gonzalo, Anette-Gabriele Ziegler
Early detection of type 1 diabetes, in its presymptomatic stage, offers significant clinical advantages, including treatment that can delay disease onset. Current screening focuses on identifying islet autoantibody positivity, with proposed optimal testing at ages 2, 6 and 10 years potentially achieving up to 80% sensitivity. However, challenges arise from participation rates and costs associated with
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Enterovirus VP1 protein and HLA class I hyperexpression in pancreatic islet cells of organ donors with type 1 diabetes Diabetol. (IF 8.4) Pub Date : 2025-03-17 Teresa Rodriguez-Calvo, Jutta E. Laiho, Maarit Oikarinen, Pouria Akhbari, Christine Flaxman, Thomas Worthington, Paola Apaolaza, John S. Kaddis, Irina Kusmartseva, Sisko Tauriainen, Martha Campbell-Thompson, Mark A. Atkinson, Matthias von Herrath, Heikki Hyöty, Noel G. Morgan, Alberto Pugliese, Sarah J. Richardson
Aims/hypothesis Earlier studies of pancreases from donors with type 1 diabetes demonstrated enteroviral capsid protein VP1 in beta cells. In the context of a multidisciplinary approach undertaken by the nPOD-Virus group, we assessed VP1 positivity in pancreas and other tissues (spleen, duodenum and pancreatic lymph nodes) from 188 organ donors, including donors with type 1 diabetes and donors expressing
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Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue Diabetol. (IF 8.4) Pub Date : 2025-03-17 Sarah J. Richardson, Teresa Rodriguez-Calvo, Jutta E. Laiho, John S. Kaddis, Julius O. Nyalwidhe, Irina Kusmartseva, Sofia Morfopoulou, Joseph F. Petrosino, Vincent Plagnol, Kathrin Maedler, Margaret A. Morris, Jerry L. Nadler, Mark A. Atkinson, Matthias von Herrath, Richard E. Lloyd, Heikki Hyoty, Noel G. Morgan, Alberto Pugliese
Aims/hypothesis Previous pathology studies have associated enterovirus infections with type 1 diabetes by examining the enterovirus capsid protein 1 (VP1) in autopsy pancreases obtained near diabetes diagnosis. The Network for Pancreatic Organ Donors with Diabetes (nPOD) has since obtained pancreases from organ donors with type 1 diabetes (with broad age and disease duration) and donors with disease-associated
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Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes Diabetol. (IF 8.4) Pub Date : 2025-03-17 Jutta E. Laiho, Sami Oikarinen, Sofia Morfopoulou, Maarit Oikarinen, Ashlie Renner, Daniel Depledge, Matthew C. Ross, Ivan C. Gerling, Judith Breuer, Joseph F. Petrosino, Vincent Plagnol, Alberto Pugliese, Antonio Toniolo, Richard E. Lloyd, Heikki Hyöty
Aims/hypothesis The nPOD-Virus group collaboratively applied innovative technologies to detect and sequence viral RNA in pancreas and other tissues from organ donors with type 1 diabetes. These analyses involved the largest number of pancreas samples collected to date. The aim of the current work was to examine the presence of enterovirus RNA in pancreas and lymphoid tissues of organ donors with and
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Exploring the shared genetic landscape of diabetes and cardiovascular disease: findings and future implications Diabetol. (IF 8.4) Pub Date : 2025-03-15 Hyunsuk Lee, Maria Fernandes, Jeongeun Lee, Jordi Merino, Soo Heon Kwak
Diabetes is a rapidly growing global health concern projected to affect one in eight adults by 2045, which translates to roughly 783 million people. The profound metabolic alterations often present in dysglycaemia significantly increase the risk of cardiovascular complications. While genetic susceptibility plays a crucial role in diabetes and its vascular complications, identifying genes and molecular
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MAP4K4 aggravates microvascular anomalies in diabetic retinopathy in a YTHDF2-dependent manner Diabetol. (IF 8.4) Pub Date : 2025-03-12 Qian Yang, Pei-wen Zhu, Yan-jun Wen, Ran Zhang, Wen-wen Chen, Xin Huang, Qing Chang
Aims/hypothesis Signalling pathways that regulate endothelial cell (EC) dysfunction, ischaemia and inflammation play a crucial role in retinal microangiopathy such as diabetic retinopathy. MAP4K4 is highly expressed in ECs. However, the involvement of MAP4K4 in retinal vasculopathy of diabetic retinopathy remains unclear. Methods We analysed publicly available single-cell RNA sequencing (scRNA-seq)
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A simple score-based strategy to improve equity of the UK biennial diabetic eye screening protocol among people deemed as low risk Diabetol. (IF 8.4) Pub Date : 2025-03-12 Matilda Pitt, Abraham Olvera-Barrios, John Anderson, Louis Bolter, Ryan Chambers, Alasdair N. Warwick, Samantha Mann, Laura Webster, Jiri Fajtl, Sarah A. Barman, Catherine Egan, Adnan Tufail, Alicja R. Rudnicka, Christopher G. Owen
Aims/hypothesis Biennial, as opposed to annual, screening for diabetic retinopathy was recently introduced within England for those considered to be at ‘low risk’. This study aims to examine the impact that annual vs biennial screening has on equitable risk of diagnosis of sight-threatening diabetic retinopathy (STDR) among people at ‘low risk’ and to develop an amelioration protocol. Methods In the
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Intrapancreatic adipocytes and beta cell dedifferentiation in human type 2 diabetes Diabetol. (IF 8.4) Pub Date : 2025-03-12 Na Zhang, Qiman Sun, Jiaxin Zhang, Ruonan Zhang, Siyi Liu, Xuelian Zhao, Jing Ma, Xiaomu Li
Aims/hypothesis Fat deposition in the pancreas is implicated in beta cell dysfunction and the progress of type 2 diabetes. However, there is limited evidence to confirm the correlation and explore how pancreatic fat links with beta cell dysfunction in human type 2 diabetes. This study aimed to examine the spatial relationship between pancreatic fat and islets in human pancreases. Methods Histological
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TBC1D30 regulates proinsulin and insulin secretion and is the target of a genomic association signal for proinsulin Diabetol. (IF 8.4) Pub Date : 2025-03-10 Victoria A. Parsons, Swarooparani Vadlamudi, Kayleigh M. Voos, Abigail E. Rohy, Anne H. Moxley, Maren E. Cannon, Jonathan D. Rosen, Christine A. Mills, Laura E. Herring, K. Alaine Broadaway, Damaris N. Lorenzo, Karen L. Mohlke
Aims/hypothesis Components of the insulin processing and secretion pathways remain incompletely understood. Here, we examined a genome-wide association study (GWAS) signal for plasma proinsulin levels. Lead GWAS variant rs150781447-T encodes an Arg279Cys substitution in TBC1 domain family member 30 (TBC1D30), but no role for this protein in insulin processing or secretion has been established previously
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Clonal haematopoiesis of indeterminate potential: an emerging risk factor for type 2 diabetes and related complications Diabetol. (IF 8.4) Pub Date : 2025-03-10 María A. Zuriaga, José J. Fuster
The accumulation of acquired somatic mutations is a natural consequence of ageing, but the pathophysiological implications of these mutations beyond cancer are only beginning to be understood. Most somatic mutations are functionally neutral, but a few may confer a competitive advantage to a stem cell, driving its clonal expansion. When such a mutation arises in haematopoietic stem cells, it leads to
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Rare MTNR1B variants causing diminished MT2 signalling associate with elevated HbA1c levels but not with type 2 diabetes Diabetol. (IF 8.4) Pub Date : 2025-03-10 Kimmie V. Sørensen, Johanne M. Justesen, Lars Ängquist, Jette Bork-Jensen, Bolette Hartmann, Niklas R. Jørgensen, Jørgen Rungby, Henrik T. Sørensen, Allan Vaag, Jens S. Nielsen, Jens J. Holst, Oluf Pedersen, Allan Linneberg, Torben Hansen, Niels Grarup
Aims/hypothesis An intronic variant (rs10830963) in MTNR1B (encoding the melatonin receptor type 2 [MT2]) has been shown to strongly associate with impaired glucose regulation and elevated type 2 diabetes prevalence. However, MTNR1B missense variants have shown conflicting results on type 2 diabetes. Thus, we aimed to gain further insights into the impact of MTNR1B coding variants on type 2 diabetes
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Research and data sovereignty in genetically admixed populations. Diabetol. (IF 8.4) Pub Date : 2025-03-11 Linda Zollner,Rajiv Kumar,Justo Lorenzo Bermejo
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Metformin therapy modifies corneal neuroimmune abnormalities in people with type 2 diabetes Diabetol. (IF 8.4) Pub Date : 2025-03-07 Amy T. Tsoi, Janice Sng, Shyam S. Tummanapalli, Tushar Issar, Ann M. Poynten, Kerry-Lee Milner, Maria Markoulli, Roshan Dhanapalaratnam, Arun V. Krishnan
Aims/hypothesis Diabetic peripheral neuropathy is a debilitating microvascular complication of diabetes mellitus, with limited disease-modifying therapies to date. This study aimed to assess the effect of metformin on the corneal sub-basal nerve plexus as a peripheral neuropathy outcome measure in people with type 2 diabetes. Methods A cohort of 36 participants with type 2 diabetes receiving metformin
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Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort Diabetol. (IF 8.4) Pub Date : 2025-03-01 Vivien J. Chebii, Alisha N. Wade, Nigel J. Crowther, Engelbert A. Nonterah, Godfred Agongo, Z. Simayi, Palwende R. Boua, Isaac Kisiangani, Michèle Ramsay, Ananyo Choudhury, Dhriti Sengupta
Aims/hypothesis Glycaemic traits such as high fasting glucose levels and insulin resistance are positively associated with the risk of type 2 diabetes and other cardiometabolic diseases. Genetic association studies have identified hundreds of associations for each glycaemic trait, yet very few studies have involved continental African populations. We report the results of genome-wide association studies
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Research and data sovereignty in genetically admixed populations. Reply to Zoller L, Kumar R and Lorenzo Bermejo J [letter]. Diabetol. (IF 8.4) Pub Date : 2025-03-01 Joseph Yracheta,Taylor Morriseau,Kali Dale,Ashlynn Gerth,Jonathan McGavock
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Brown adipose tissue alleviates podocyte apoptosis through NRG4 in a male mouse model of diabetic kidney disease Diabetol. (IF 8.4) Pub Date : 2025-02-27 Sheng Ding, Jin-ling Xu, Jia-yue Tong, Yang-yang Cheng, Ling-feng Shi, Wei Wei, Li-ming Zhang, Jia-jia Zhang, Bi-ying Meng, Xiang-yan Peng, Lin Xiang, Shu-guang Li, Ling Yue, Zhong-jing Wang, Guang-da Xiang
Aims/hypothesis Brown adipose tissue (BAT) consumes excess energy through heat production by uncoupling protein 1 (UCP1) to regulate the metabolic profile, but the UCP1-independent mechanisms of BAT, such as in endocrine function, are largely unknown. Our previous study showed that BAT-derived neuregulin 4 (NRG4) displays anti-atherosclerotic properties. Thus, we hypothesised that BAT could regulate
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Cardiac arrhythmia and hypoglycaemia among individuals with and without diabetes receiving haemodialysis (the CADDY study): a Danish multicentre cohort study Diabetol. (IF 8.4) Pub Date : 2025-02-28 Dea H. Kofod, Søren Z. Diederichsen, Tobias Bomholt, Mads Ø. Andersen, Andreas Andersen, Ebba Mannheimer, Marianne Rix, Ylian S. Liem, Kristine Lindhard, Henrik P. Hansen, Casper Rydahl, Morten Lindhardt, Julie Brøsen, Kristine Schandorff, Theis Lange, Kirsten Nørgaard, Thomas P. Almdal, Jesper H. Svendsen, Bo Feldt-Rasmussen, Mads Hornum
Aims/hypothesis We aimed to examine arrhythmias and hypoglycaemia among individuals with and without diabetes who are receiving haemodialysis and to investigate the association between arrhythmias and hypoglycaemia, hyperglycaemia and glycaemic variability. Methods This prospective multicentre cohort study included 70 participants on maintenance haemodialysis (35 with diabetes and 35 without diabetes)
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IA-2A positivity increases risk of progression within and across established stages of type 1 diabetes Diabetol. (IF 8.4) Pub Date : 2025-02-28 Emily K. Sims, David Cuthbertson, Lauric A. Ferrat, Emanuele Bosi, Carmella Evans-Molina, Linda A. DiMeglio, Brandon M. Nathan, Heba M. Ismail, Laura M. Jacobsen, Maria J. Redondo, Richard A. Oram, Jay M. Sosenko
Aims/hypothesis Accurate understanding of type 1 diabetes risk is critical for optimisation of counselling, monitoring and interventions, yet even within established staging classifications, individual time to clinical disease varies. Previous work has associated IA-2A positivity with increased type 1 diabetes progression but a comprehensive assessment of the impact of screening for IA-2A positivity
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Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes affirms markers of disease Diabetol. (IF 8.4) Pub Date : 2025-02-28 Robert Moulder, M. Karoliina Hirvonen, Tommi Välikangas, Tomi Suomi, Lut Overbergh, Mark Peakman, Søren Brunak, Chantal Mathieu, Mikael Knip, Laura L. Elo, Riitta Lahesmaa
Aims/hypothesis While investigating markers for declining beta cell function in type 1 diabetes, we previously demonstrated 11 statistically significant protein associations with fasting C-peptide/glucose ratios in longitudinal serum samples from newly diagnosed (ND) individuals (n=86; 228 samples in total) participating in the INNODIA (Innovative approaches to understanding and arresting type 1 diabetes)
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Beyond the loss of beta cells: a quantitative analysis of islet architecture in adults with and without type 1 diabetes Diabetol. (IF 8.4) Pub Date : 2025-02-26 Nicolás Verschueren van Rees, Peter Ashwin, Conor McMullan, Lars Krogvold, Knut Dahl-Jørgensen, Noel G. Morgan, Pia Leete, Kyle C. A. Wedgwood
Aims/hypothesis The organisation and cellular architecture of islets of Langerhans are critical to the physiological regulation of hormone secretion but it is debated whether human islets adhere to the characteristic mantle–core (M-C) structure seen in rodents. It is also unclear whether inherent architectural changes contribute to islet dysfunction in type 1 diabetes, aside from the loss of beta cells
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Associations between the timing of 24 h physical activity and diabetes mellitus: results from a nationally representative sample of the US population Diabetol. (IF 8.4) Pub Date : 2025-02-21 Qian Xiao, Qiuyu Feng, Martin K. Rutter, Gali Albalak, Heming Wang, Raymond Noordam
Aims/hypothesis Growing evidence suggests that timing may be an important aspect of physical activity that influences cardiometabolic health. However, the current literature is inconclusive regarding the time of day that physical activity offers the greatest metabolic advantages. We investigated associations between hourly physical activity levels and diabetes mellitus and glycaemic biomarkers in a
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Pregnancy and neonatal outcomes in women with GCK-MODY: an observational study based on standardised insulin modalities Diabetol. (IF 8.4) Pub Date : 2025-02-19 Cécile Ciangura, Aurélien Seco, Cécile Saint-Martin, Pierre-Yves Ancel, Delphine Bouvet, Sophie Jacqueminet, Agnès Hartemann, Jacques Lepercq, Jacky Nizard, José Timsit, Christine Bellanné-Chantelot
Aims/hypothesis The management of GCK-MODY during pregnancy remains challenging. We evaluated the impact on pregnancy and neonatal outcomes of two standardised insulin strategies. Methods In this prospective observational study, participants chose (in agreement with their physician) to be treated with insulin either when maternal capillary blood glucose (CBG) ≥ thresholds for gestational diabetes (5
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Epigenome-wide association study of incident type 2 diabetes in Black and White participants from the Atherosclerosis Risk in Communities Study Diabetol. (IF 8.4) Pub Date : 2025-02-19 Sowmya Venkataraghavan, James S. Pankow, Eric Boerwinkle, Myriam Fornage, Elizabeth Selvin, Debashree Ray
Aims/hypothesis DNA methylation studies of incident type 2 diabetes in US populations are limited and to our knowledge none include individuals of African descent. We aimed to fill this gap by identifying methylation sites (CpG sites) and regions likely influencing the development of type 2 diabetes using data from Black and White individuals from the USA. Methods We prospectively followed 2091 Black
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Islet autoantibodies in Thai individuals individuals diagnosed with type 1 diabetes before 30 years of age: a large multicentre nationwide study Diabetol. (IF 8.4) Pub Date : 2025-02-19 Nattachet Plengvidhya, Sarocha Suthon, Tassanee Nakdontri, Nipaporn Teerawattanapong, Saranya Ingnang, Watip Tangjittipokin
Aims/hypothesis Type 1 diabetes is categorised into autoantibody positive and autoantibody negative. Most type 1 diabetes research has focused on European populations, leaving a gap in understanding in relation to other ethnic groups, including Thai populations. This lack of data is significant given Thailand’s poor prevention and therapeutic management strategies. We aimed to investigate the frequency
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Identification and interpretation of risk factors for Charcot foot. Reply to Milbourn VEL, Bus SA, Game F, van Netten JJ [letter]. Diabetol. (IF 8.4) Pub Date : 2025-02-20 Georgios Tsatsaris,Neda Rajamand Ekberg,Tove Fall,Sergiu-Bogdan Catrina
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Identification and interpretation of risk factors for Charcot foot. Diabetol. (IF 8.4) Pub Date : 2025-02-20 Victoria E L Milbourn,Sicco A Bus,Frances Game,Jaap J van Netten
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How should we define subtypes of gestational diabetes mellitus? Reply to Göbl C, Tura A [letter]. Diabetol. (IF 8.4) Pub Date : 2025-02-15 Danielle L Jones,Laura C Kusinski,Clare Gillies,Claire L Meek
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How should we define subtypes of gestational diabetes mellitus? Diabetol. (IF 8.4) Pub Date : 2025-02-15 Christian Göbl,Andrea Tura
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Differential associations of somatic and cognitive-affective symptoms of depression with inflammation and insulin resistance: cross-sectional and longitudinal results from the Emotional Distress Sub-Study of the GRADE study Diabetol. (IF 8.4) Pub Date : 2025-02-14 Dominic Ehrmann, Heidi Krause-Steinrauf, Diane Uschner, Hui Wen, Claire J. Hoogendoorn, Gladys Crespo-Ramos, Caroline Presley, Valerie L. Arends, Robert M. Cohen, W. Timothy Garvey, Thomas Martens, Holly J. Willis, Andrea Cherrington, Jeffrey S. Gonzalez
Aims/hypothesis Insulin resistance and inflammation are components of a biological framework that is hypothesised to be shared by type 2 diabetes and depression. However, depressive symptoms include a large heterogeneity of somatic and cognitive-affective symptoms, and this may obscure the associations within this biological framework. Cross-sectional and longitudinal data were used to disentangle
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Diabetic gastroenteropathy: a pan-alimentary complication Diabetol. (IF 8.4) Pub Date : 2025-02-11 Ditte S. Kornum, Klaus Krogh, Jutta Keller, Carolina Malagelada, Asbjørn M. Drewes, Christina Brock
Autonomic neuropathy contributes to the pathophysiology of diabetic gastroenteropathy, which impacts the entire gastrointestinal tract alongside pancreatic and gallbladder functions. This is evident in the widespread morphological remodelling of the enteric nervous system, smooth muscle cells, interstitial cells of Cajal and vascular supply, causing pan-enteric motor, sensory and secretory disturbances
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Continuous glucose monitor metrics from five studies identify participants at risk for type 1 diabetes development Diabetol. (IF 8.4) Pub Date : 2025-02-11 Peter Calhoun, Charles Spanbauer, Andrea K. Steck, Brigitte I. Frohnert, Mark A. Herman, Bart Keymeulen, Riitta Veijola, Jorma Toppari, Aster Desouter, Frans Gorus, Mark Atkinson, Darrell M. Wilson, Susan Pietropaolo, Roy W. Beck
Aims/hypothesis We aimed to assess whether continuous glucose monitor (CGM) metrics can accurately predict stage 3 type 1 diabetes diagnosis in those with islet autoantibodies (AAb). Methods Baseline CGM data were collected from participants with ≥1 positive AAb type from five studies: ASK (n=79), BDR (n=22), DAISY (n=18), DIPP (n=8) and TrialNet Pathway to Prevention (n=91). Median follow-up time
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One-year real-world benefits of Tandem Control-IQ technology on glucose management and person-reported outcomes in adults with type 1 diabetes: a prospective observational cohort study Diabetol. (IF 8.4) Pub Date : 2025-02-11 Jolien De Meulemeester, Bart Keymeulen, Christophe De Block, Liesbeth Van Huffel, Youri Taes, Dominique Ballaux, Katrien Spincemaille, Bruno Lapauw, Gerd Vanhaverbeke, Ine Lowyck, Chris Vercammen, Ides M. Colin, Vanessa Preumont, Sara Charleer, Steffen Fieuws, Chantal Mathieu, Pieter Gillard
Aims/hypothesis This multicentre prospective observational cohort study aimed to evaluate real-world changes in glycaemic and person-reported outcomes after 1 year’s use of Control-IQ technology in adults with type 1 diabetes. Methods Adults who started with Control-IQ between December 2021 and December 2022 were consecutively recruited in 13 Belgian diabetes centres. Data were collected at start and
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Considerations for more actionable consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes. Reply to Mallone R [letter]. Diabetol. (IF 8.4) Pub Date : 2025-02-12 Moshe Phillip,Peter Achenbach,Ananta Addala,Anastasia Albanese-O'Neill,Tadej Battelino,Kirstine J Bell,Rachel E J Besser,Ezio Bonifacio,Helen M Colhoun,Jennifer J Couper,Maria E Craig,Thomas Danne,Carine de Beaufort,Klemen Dovc,Sanjoy Dutta,Osagie Ebekozien,Helena Elding Larsson,Brigitte I Frohnert,Mary P Gallagher,Carla J Greenbaum,Kurt J Griffin,William Hagopian,Michael J Haller,Emile Hendriks,Richard
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Partnership and marriage and risk of type 2 diabetes: a narrative review Diabetol. (IF 8.4) Pub Date : 2025-02-07 Bernd Kowall, Wolfgang Rathmann
In this review, we discuss how partnership and marriage influence cardiometabolic risk factors and risk of type 2 diabetes, and how couple-based approaches to type 2 diabetes prevention might complement individual-focused prevention efforts. There is some evidence that being married per se has a small positive effect on type 2 diabetes risk. Moreover, there is spousal concordance for many type 2 diabetes
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Birthweight and risk of chronic kidney disease after a type 2 diabetes diagnosis in the DD2 cohort Diabetol. (IF 8.4) Pub Date : 2025-02-01 Aleksander L. Hansen, Christian F. Christiansen, Charlotte Brøns, Leonie M. Engelhard, Torben Hansen, Jens S. Nielsen, Peter Vestergaard, Kurt Højlund, Niels Jessen, Michael H. Olsen, Henrik T. Sørensen, Peter Rossing, Reimar W. Thomsen, Allan Vaag
Aims/hypothesis Low birthweight (LBW) is associated with younger age, less obesity and more hypertension among people recently diagnosed with type 2 diabetes, as well as increased cardiovascular morbidity and mortality risk. It is not known whether LBW is associated with an increased risk of incident chronic kidney disease (CKD) among people with a type 2 diabetes diagnosis. Methods Original midwife
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High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response Diabetol. (IF 8.4) Pub Date : 2025-01-30 Shaoyong Zhuang, Nan Sun, Junwen Qu, Qian Chen, Conghui Han, Hao Yin, Xiaodong Yuan, Ming Zhang
Aims/hypothesis Diabetic kidney disease (DKD) features intrarenal inflammation, in which T cells play a part. Hypoxia-inducible factor-1α (HIF-1α), a key transcription factor regulating cellular responses to hypoxia, is reportedly involved in the course of inflammation. The role of HIF-1α in DKD has been investigated, but the conclusions are controversial so far. We report a previously unrecognised
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Comparison of continuous glucose monitoring with self-monitoring of blood glucose in type 1 diabetes in the changing atmospheric pressures in aviation: a hypobaric flight simulation Diabetol. (IF 8.4) Pub Date : 2025-01-31 Ka Siu Fan, Antonios Manoli, Petra M. Baumann, Fariba Shojaee-Moradie, Fereshteh Jeivad, Gerd Koehler, Monika Cigler, A. Margot Umpleby, David Russell-Jones, Julia K. Mader
Aim/hypothesis Pilots with type 1 diabetes are required to perform capillary glucose monitoring regularly during flights. Continuous glucose monitoring (CGM) may be an effective and more practical alternative. This study aimed to assess the accuracy of CGM systems against self-monitoring of blood glucose (SMBG) during a hypobaric flight simulation. Methods Twelve insulin pump users with type 1 diabetes
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Intestinal neutrophil extracellular traps promote gut barrier damage exacerbating endotoxaemia, systemic inflammation and progression of diabetic retinopathy in type 2 diabetes Diabetol. (IF 8.4) Pub Date : 2025-01-28 Jason L. Floyd, Ram Prasad, Mariana D. Dupont, Yvonne Adu-Rutledge, Shambhavi Anshumali, Sarbodeep Paul, Sergio Li Calzi, Xiaoping Qi, Akanksha Malepati, Emory Johnson, Patricia Jumbo-Lucioni, Jason N. Crosson, John O. Mason, Michael E. Boulton, Robert S. Welner, Maria B. Grant
Aims/hypothesis Within the small intestine, neutrophils play an integral role in preventing bacterial infection. Upon interaction with bacteria or bacteria-derived antigens, neutrophils initiate a multi-staged response of which the terminal stage is NETosis, formation of protease-decorated nuclear DNA into extracellular traps. NETosis has a great propensity to elicit ocular damage and has been associated