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SLAMF4 orchestrates the cytotoxic response of CD4+ T cells in rheumatoid arthritis Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-02-03 Mégane Lacaud, Houda‐Ghozlane Bouzidi, Mylène Petit, Magali Breckler, Delphine Lemeiter, Johanna Sigaux, Elodie Rivière, Luca Semerano, Marie‐Christophe Boissier, Natacha Bessis, Jérôme Biton
ObjectiveThis study aimed to assess whether signaling lymphocytic activation molecule family receptors (SLAMFs) are involved in the shaping of the pathological response of CD4+ T cells in rheumatoid arthritis (RA).MethodsPeripheral blood (PB) and synovial fluid (SF) mononuclear cells from RA patients were freshly isolated. In RA, we used a multi‐modal approach to determine the involvement of numerous
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Correction to CD19 Chimeric Antigen Receptor T Cell Treatment: Unraveling the Role of B Cells in Systemic Lupus Erythematosus Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-31
Correction to “Figure 3. Key insights from CAR T cell therapy in SLE.” Figure 3 Open in figure viewerPowerPoint Arthritis & Rheumatology Vol. 76, No. 4, April 2024, pp 497–504 DOI 10.1002/art.42784 In the middle panel of this figure, the plasma cells are identified as “CD19+CD20-” (same as the plasmablasts) – but one key point of the paper is that they are not CD19+. It should read “CD19– CD20–”. Also
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Issue Information Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-31
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In This Issue Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-31
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Journal Club Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-31
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Clinical Connections Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-31
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Serum Type I Interferon Score predicts clinically meaningful disease progression in limited cutaneous Systemic Sclerosis Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-30 Stefano Di Donato, Rebecca Ross, Ranjitha Karanth, Vishal Kakkar, Enrico De Lorenzis, Lesley‐Anne Bissell, Kristina Clark, Philip Yee, Christopher P. Denton, Francesco Del Galdo
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Genome‐wide aggregated trans‐ effects analysis identifies genes encoding immune checkpoints as core genes for rheumatoid arthritis Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-30 Athina Spiliopoulou, Andrii Iakovliev, Darren Plant, Megan Sutcliffe, Seema Sharma, Cankut Cubuk, Myles Lewis, Costantino Pitzalis, Anne Barton, Paul M McKeigue
ObjectivesThe sparse effector “omnigenic” hypothesis postulates that the polygenic effects of common SNPs on a typical complex trait are mediated by trans‐ effects that coalesce on expression of a relatively sparse set of core genes. The objective of this study was to identify core genes for rheumatoid arthritis by testing for association of rheumatoid arthritis with genome‐wide aggregated trans‐ effects
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Commentary on Abernathy‐Close et al: Study on Mupirocin Treatment in Cutaneous Lupus Erythematosus Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-27 Marianna Di Rosa, Alessia Pin, Giulia Maria Piperno, Serena Pastore, Alberto Tommasini, Alessandra Tesser
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Systemic Sclerosis: A Multisystem Disease; Time to Think Beyond Scleroderma Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-27 Yannick Allanore, Shervin Assassi
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Efficacy, Safety, Pharmacokinetics, and Immunogenicity of ABBV‐154 in Adults With Glucocorticoid‐Dependent Polymyalgia Rheumatica: A Phase 2, Randomized, Double‐Blind, Placebo‐Controlled Trial Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-27 Robert F. Spiera, Valerie Devauchelle‐Pensec, Claire E. Owen, Federico Díaz‐González, Tsutomu Takeuchi, Edit Drescher, Jaclyn Anderson, Dilek Arikan, Ronilda D'Cunha, Julie Parmentier, Denise T. Kruzikas, Weihan Zhao, Yang Yang, Karen Stellpflug, Frank Buttgereit
ObjectiveAn unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.MethodsIn this phase 2, randomized, double‐blind, placebo‐controlled, dose‐ranging study, eligible
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Reply to commentary by Di Rosa et. al: BCAP in CLE Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-27 Lisa Abernathy‐Close, Allison C. Billi, J. Michelle Kahlenberg
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Unexplored Limitations in the SLEek Trial of Upadacitinib and Elsubrutinib Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-27 Qianyu Guo, Junkang Zhao, James Cheng‐Chung Wei, Li‐yun Zhang
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Authors Reply to Letter from Guo et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-27 Joan T. Merrill, Marie‐Claude Gaudreau, Kristin M. D'Silva
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Pro‐inflammatory dietary pattern and the risk of female gout: sex‐specific findings from three prospective cohort studies Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-27 Sharan K. Rai, Hyon K. Choi, Na Lu, Chio Yokose, Kehuan Lin, Dong Hoon Lee, Fred K. Tabung, Natalie McCormick
ObjectiveWe aimed to determine whether a pro‐inflammatory dietary pattern (mechanism‐based diet) is associated with incident female gout among two large cohorts of US women.MethodsWe prospectively followed 79,104 women from Nurses’ Health Study (NHS; 1984‐2016) and 93,454 women from NHSII (1991‐2017); 45,445 men from Health Professionals Follow‐up Study (1986‐2016) served as a comparison cohort. Validated
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Clinical Images: Granulomatosis with polyangiitis presenting as strawberry gingivitis: diagnostic challenges with negative antineutrophil cytoplasmic antibody Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-22 Hanghang Liu, Wenting Qi, Qi Han, Linyi Liu, Yongle Shi, En Luo, Chongyun Bao, Xian Liu
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An immunosenescent CD8+ T cell subset in patients with axial Spondyloarthritis and Psoriatic Arthritis links spontaneous motility to telomere shortening and dysfunction Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-21 Giorgia Paldino, Valentina Tedeschi, Valentina Proganò, Erica Salvati, Valerio Licursi, Eleonora Vertecchi, Alexandru L. Bivolaru, Emanuele Molteni, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Martina Kunkl, Loretta Tuosto, Rosa Sorrentino, Maria Teresa Fiorillo
ObjectiveA pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r‐axSpA) and other spondyloarthritis (SpA) is sustained by genome‐wide association studies (GWAS) and by the expansion of public T cell clonotypes in the target tissues. This study investigates the migration of CD8+ T cells, along with their phenotype and functions in patients with r‐axSpA and psoriatic arthritis
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The Gut Microbiome in Hyperuricemia and Gout Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-20 Robert Terkeltaub, Dylan Dodd
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A treatable cause of bilateral leg edema and pleural effusion: yellow nail syndrome with IgG4‐related disease Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-20 Seiya Oba, Yusuke Matsuo
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Comments on “Risk of Gastrointestinal Perforation in Patients With Rheumatic Diseases Exposed to Janus Kinase Inhibitors Versus Adalimumab: A Nationwide Cohort Study” Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-20 Jing‐jin Hu, Yang‐yang Lu, Jun‐kang Zhao, Dan Ma, James Cheng‐Chung Wei, Li‐yun Zhang
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The National Academies’ 2024 Diagnostic Criteria for Long COVID: Concerns That Could Affect the Rheumatology Community Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-16 Leonard H. Calabrese, Michael Putman, Jeffrey A. Sparks, Zachary Wallace, Alfred H. J. Kim, Kevin L. Winthrop, Cassandra Calabrese
Introduction Shortly after the COVID-19 pandemic began, it became clear that some people with COVID-19 had prolonged or, in some cases, incomplete recovery. Patient-led groups took an early and important role in advocating for affected people, coining the term “long COVID.”1 The term postacute sequelae of COVID-19 (PASC) is often used interchangeably with long COVID, with the latter enduring as the
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Proteomic profiling of the large‐vessel vasculitis spectrum identifies shared signatures of innate immune activation and stromal remodelling Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-16 Robert T. Maughan, Erin MacDonald‐Dunlop, Lubna Haroon‐Rashid, Louise Sorensen, Natalie Chaddock, Shauna Masters, Andrew Porter, Marta Peverelli, Charis Pericleous, Andrew Hutchings, James Robinson, Taryn Youngstein, Raashid A. Luqmani, Justin C. Mason, Ann W. Morgan, James E. Peters
BackgroundTakayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large‐vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments.MethodsPlasma proteomic profiling of 184 proteins was performed in two cohorts. Cohort 1 included patients with established TAK (n=96) and large‐vessel
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Immune Aging in Rheumatoid Arthritis Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-13 Cornelia M. Weyand, Jörg J. Goronzy
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Critical role for Transglutaminase 2 in scleroderma skin fibrosis and in the development of dermal sclerosis in a mouse model of scleroderma Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-13 Angela Y.Y. Tam, Korsa Khan, Shiwen Xu, Marianne Bergin, Linghong Huang, Erik Arroyo Colon, Danyi Cheng, Elisabetta AM Verderio, Voon Ong, Christopher P Denton, John Atkinson, Tim S Johnson, David J. Abraham
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Induction of Type I Interferon–Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes by UV Light Exposure Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-12 Xizhang Sun, Jaime L. Chao, Michael Gerner, Keith B. Elkon
Photosensitivity occurs in ~75% of patients with lupus. Although UV light radiation (UVR) stimulates type I interferon (IFN-I) in the skin, how UVR-induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes dendritic cells (DCs) to migrate from organs to draining lymph nodes (dLN), including a recently identified inflammatory conventional DC subset (inf cDC2)
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Associations of Fire Smoke and Other Pollutants With Incident Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Interstitial Lung Disease Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-12 Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England
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Reply Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-12 Sindhu R. Johnson, Marcy B. Bolster, Sonye K. Danoff, Michael George, Gordon Guyatt, Reza D. Mirza, Dinesh Khanna, Aberdeen Allen, Amy Turner, Elana J. Bernstein
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Air Pollution's Hidden Toll: Risks for Rheumatoid Arthritis and Rheumatoid Arthritis–Associated Lung Disease Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-12 Sofia Ajeganova, Jeremy Sokolove
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Avoiding placebo as control treatment in rheumatology trials: can we do better? Comment on the article by Kivitz et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-08 Maarten Boers
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2023 American College of Rheumatology/American College of Chest Physicians guideline for the screening and monitoring of interstitial lung disease in people with systemic autoimmune rheumatic diseases: comment on the article by Johnson et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-08 Julian Segan, Michael Putman, Richard Conway
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Reply Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-08 Elvira D'Andrea, Shirley Wang
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Limitations in the real-world emulation of the HORIZON-Pivotal Fracture Trial: comment on the article by D'Andrea et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2025-01-08 Peng Shih-Kuei, Poi Kuo, James Cheng-Chung Wei
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Journal Club Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-31
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Issue Information Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-31
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In This Issue Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-31
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Clinical Connections Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-31
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Disturbed spatial WNT activation – a potential driver of the reticularized skin phenotype in Systemic Sclerosis (SSc) Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-26 Sara Chenguiti Fakhouri, Honglin Zhu, Yi‐Nan Li, Moritz Ronicke, Aleix Rius Rigau, Clara Dees, Laura Konstantinidis, Ralf Schmid, Alexandru‐Emil Matei, Markus Eckstein, Carol Geppert, Ingo Ludolph, Alexander Kreuter, Michael Sticherling, Carola Berking, Raymund E. Horch, Georg Schett, Jörg H.W. Distler, Christina Bergmann
ObjectivesLittle is known on the mechanisms necessary to maintain the physiological adult human skin integrity. This study aims to quantitatively describe anatomical changes in systemic sclerosis (SSc)‐skin compared to controls and investigate the underlying mechanisms.MethodsSkin morphology was histologically assessed in twenty‐three SSc‐patients, eighteen controls and fifteen patients with hypertrophic
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Absence of Functional Autoantibodies Targeting Angiotensin II Receptor Type 1 and Endothelin-1 Type A Receptor in Circulation and Purified IgG From Patients With Systemic Sclerosis Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-25 Wieke M. van Oostveen, Eva M. Hoekstra, E. W. Nivine Levarht, Ilana B. Kotliar, Thomas P. Sakmar, René E. M. Toes, Jeska K. de Vries-Bouwstra, Laura H. Heitman, Cynthia M. Fehres
Systemic sclerosis (SSc) is a rare but severe autoimmune disease characterized by immune dysregulation, fibrosis, and vasculopathy. Although previous studies have highlighted the presence of functional autoantibodies targeting the angiotensin II receptor type 1 (AT1) and endothelin-1 type A receptor (ETAR), leading to autoantibody-mediated receptor stimulation and subsequent activation of endothelial
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Distinct Pathophysiologic Pathways Support Stratification of Sjögren's Disease Based on Symptoms, Clinical, and Routine Biological Data Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-25 Yann Nguyen, Maxime Beydon, Jacques-Eric Gottenberg, Jacques Morel, Aleth Perdriger, Emmanuelle Dernis, Divi Cornec, Valérie Devauchelle-Pensec, Damien Sène, Philippe Dieudé, Marion Couderc, Anne-Laure Fauchais, Claire Larroche, Olivier Vittecoq, Carine Salliot, Eric Hachulla, Véronique Le Guern, Xavier Mariette, Raphaèle Seror, Gaëtane Nocturne
Recently, three distinct phenotypes of patients with Sjögren disease (SjD) have been described based on cluster analysis: B cell active with low symptoms (BALS), high systemic activity (HSA), and low systemic activity with high symptoms (LSAHS). We aimed to assess whether these clusters were associated with distinct biomarkers and the prognostic value of interferon (IFN) signature.
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Atherosclerotic Plaque Progression and Incident Cardiovascular Events in a 10-Year Prospective Study of Patients With Systemic Lupus Erythematosus: The Impact of Persistent Cardiovascular Risk Factor Target Attainment and Sustained DORIS Remission Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-25 Nikolaos Papazoglou, Petros P. Sfikakis, Maria G. Tektonidou
Cardiovascular disease (CVD) is a leading cause of death in individuals with systemic lupus erythematosus (SLE). We assessed atherosclerotic plaque progression and incident cardiovascular events in patients with SLE over a 10-year follow-up.
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Reply Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-25 Wayne Y. W. Lee, Rongliang Wong
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Metabolic Stress expands Polyfunctional, Proinflammatory Th17 cells in Psoriatic Arthritis, where there is IL‐23‐independent IL‐17 production Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-23 Carmel B. Stober, Louise Ellis, Jane C. Goodall, Marc Veldhoen, J.S. Hill Gaston
ObjectiveGenetic associations and blockade of the interleukin‐23/IL‐17 axis with monoclonal antibodies support a role for this pathway in psoriatic arthritis (PsA). This study examines the requirement of IL‐23 for IL‐17 production, and the role of the metabolic microenvironment in the expansion of Th17‐derived cells in PsA.MethodsPsA patient synovial fluid or peripheral blood Th17 cell frequencies
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Targeting long noncoding RNA H19 in subchondral bone osteocytes and cartilage degradation in osteoarthritis: comment on the article by Wang et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-22 An-Fang Huang, Wang-Dong Xu
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Expert Perspective: Management of Relapses in Giant Cell Arteritis Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-22 Marco A. Alba, Sebastian Unizony, Kenneth J. Warrington, Giuseppe Murgia, Sergio Prieto-González, Carlo Salvarani, Eric L. Matteson, Tanaz A. Kermani
Giant cell arteritis (GCA) is a relapsing large vessel vasculitis with risk of serious ischemic manifestations, including vision loss and vascular damage in the form of large artery stenosis, aneurysms, and dissections. Approximately 50% of patients treated with glucocorticoid (GC) monotherapy and 30% of patients receiving adjunctive therapy with tocilizumab experience disease relapses, often during
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Clinical Images: Transient perivascular inflammation of the carotid artery syndrome Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-22 Neeharika Namineni, Sowmya Mahalingam, Abhijeet Danve
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Association of Synovial Innate Immune Exhaustion With Worse Pain in Knee Osteoarthritis Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-17 Holly T. Philpott, Trevor B. Birmingham, Garth Blackler, J. Daniel Klapak, Alexander J. Knights, Easton C. Farrell, Benoit Fiset, Logan A. Walsh, J. Robert Giffin, Edward M. Vasarhelyi, Steven J. MacDonald, Brent A. Lanting, Tristan Maerz, C. Thomas Appleton
Uncontrolled pain remains a major clinical challenge in the management of knee osteoarthritis (OA), the most common disabling joint disease. Worse pain is associated with synovial innate immune cell infiltration (synovitis), but the role of innate immune-regulatory cells in pain is unknown. Our objective was to identify synovial innate immune cell subsets and pathophysiologic mechanisms associated
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Meta-analyses uncover the genetic architecture of Idiopathic Inflammatory Myopathies Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Catherine Zhu, Younghun Han, Jinyoung Byun, Xiangjun Xiao, Simon Rothwell, Frederick W. Miller, Ingrid E. Lundberg, Peter K. Gregersen, Jiri Vencovsky, Vikram R. Shaw, Neil McHugh, Vidya Limaye, Albert Selva-O'Callaghan, Michael G. Hanna, Pedro M. Machado, Lauren M. Pachman, Ann M. Reed, Lisa G. Rider, Øyvind Molberg, Olivier Benveniste, Timothy Radstake, Andrea Doria, Jan L. De Bleecker, Boel De Paepe
Idiopathic inflammatory myopathies (myositis, IIMs) are rare, systemic autoimmune disorders that lead to muscle inflammation, weakness, and extra-muscular manifestations, with a strong genetic component influencing disease development and progression. Previous genome-wide association studies identified loci associated with IIMs. In this study, we imputed data from two prior genome-wide myositis studies
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Endogenous Retroelement Activation is Implicated in Interferon-α Production and Anti–Cyclic Citrullinated Peptide Autoantibody Generation in Early Rheumatoid Arthritis Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Faye A. H. Cooles, Gemma Vidal Pedrola, Najib Naamane, Arthur G. Pratt, Ben Barron-Millar, Amy E. Anderson, Catharien M. U. Hilkens, John Casement, Vincent Bondet, Darragh Duffy, Fan Zhang, Ruchi Shukla, John D. Isaacs
Endogenous retroelements (EREs) stimulate type 1 interferon (IFN-I) production but have not been explored as potential interferonogenic triggers in rheumatoid arthritis (RA). We investigated ERE expression in early RA (eRA), a period in which IFN-I levels are increased.
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Cross‐Phenotype Genome‐Wide Association Study Supports Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Yiming Luo, Atlas Khan, Lili Liu, Cue Hyunkyu Lee, Gabriel J Perreault, Sydney F Pomenti, Pravitt Gourh, Krzysztof Kiryluk, Elana J Bernstein
ObjectiveAn increased risk of primary biliary cholangitis (PBC) has been reported in patients with systemic sclerosis (SSc). Our study aims to investigate the shared genetic susceptibility between the two disorders and to define candidate causal genes using cross‐phenotype GWAS meta‐analysis.MethodsWe performed cross‐phenotype GWAS meta‐analysis and Bayesian colocalization analysis for SSc and PBC
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The oral microbiota in persons at risk for rheumatoid arthritis: follow-up data for the article by Kroese et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Johanna M. Kroese, Bernd W. Brandt, Mark J. Buijs, Wim Crielaard, Frank Lobbezoo, Bruno G. Loos, Laurette van Boheemen, Dirkjan van Schaardenburg, Egija Zaura, Catherine M.C. Volgenant
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Reply Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Edoardo Cipolletta, Laila J. Tata, Abhishek Abhishek
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Enhancing knee osteoarthritis prediction: comment on the article by Li et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Qin Guo, Hui Li, Chengshan Guo
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Changes in Descending Pain Modulation During Anti–Tumor Necrosis Factor Therapy: A Prospective Study in Rheumatoid Arthritis and Spondyloarthritis Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Anne-Priscille Trouvin, Arielle Simunek, Joël Coste, Terkia Medkour, Alice Combier, Lucile Poiroux, François Vidal, Sandrine Carvès, Didier Bouhassira, Serge Perrot
In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of biologic disease-modifying antirheumatic drugs (bDMARDs). The objective of the Rheumatism Pain Inhibitory Descending Pathways study was to assess pain thresholds and descending pain modulation in patients with active
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Association of Therapies for Axial Spondyloarthritis on the Risk of Hip and Spine Fractures Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Devin Driscoll, Navya George, Christine Peloquin, S. Reza Jafarzadeh, Jean W. Liew, Maureen Dubreuil
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Revisiting the Synovium as a Structural Correlate of Pain in Osteoarthritis Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Rachel E. Miller, Richard F. Loeser
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Short-Term Risk of Cardiovascular Events in People Newly Diagnosed With Gout: Comment on the Article by Cipolletta et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Zichang Liu, Yanwei Zhu, Hui Zhao
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Reply Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-16 Shengfa Li, Changhai Ding
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Topical Mupirocin Treatment Reduces Interferon and Myeloid Signatures in Cutaneous Lupus Erythematous Lesions Through Targeting of Staphyloccal Species Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-08 Lisa Abernathy-Close, Joseph Mears, Allison C. Billi, Sirisha Sirobhushanam, Celine Berthier, Annie Lu, Zeran Zhang, Amy Hurst, Johann E. Gudjonsson, J. Michelle Kahlenberg
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Outcome of Patients With Lupus Nephritis Treated With an Anti-CD40 Monoclonal Antibody According to Kidney Biopsy Features Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-08 Martina Uzzo, Helmut Schumacher, Juergen Steffgen, Simone Deutschel, David Jayne, Ingeborg Bajema
A phase 2 trial tested different doses of the anti-CD40 monoclonal antibody BI 655064 as an add-on therapy to the standard of care in patients with class III or IV lupus nephritis (LN) with active disease. A post hoc analysis showed a potential benefit of the higher tested doses (180 and 240 mg) versus a low dose (120 mg) or placebo. We investigated whether the treatment effect of BI 655064 on kidney
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Balancing weight reduction benefits and risks: implications for serum urate management: comment on the article by Fukui et al Arthritis Rheumatol. (IF 11.4) Pub Date : 2024-12-05 Pei Liu, Yongqiang Sun, Kun Zhao, Peijian Tong
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