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Peripheral blood DNA methylation-based machine learning models for prediction of knee osteoarthritis progression: biospecimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-08-12 Christopher M. Dunn, Cassandra Sturdy, Cassandra Velasco, Leoni Schlupp, Emmaline Prinz, Vladislav Izda, Liubov Arbeeva, Yvonne M. Golightly, Amanda E. Nelson, Matlock A. Jeffries
The lack of accurate biomarkers to predict knee osteoarthritis (OA) progression is a key unmet need in the OA field. The objective of this study was to develop baseline peripheral blood epigenetic biomarker models to predict knee OA progression.
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The Role of Genetics in Clinically Suspect Arthralgia and Rheumatoid Arthritis Development: a Large Cross-Sectional Study Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-08-12 Marc P. Maurits, Fenne Wouters, Ellis Niemantsverdriet, Thomas W.J. Huizinga, Erik B. van den Akker, Saskia Le Cessie, Annette H. M. van der Helm-van Mil, Rachel Knevel
To investigate whether established genetic predictors for Rheumatoid Arthritis (RA), differentiate Healthy Controls (HC), Clinically Suspect Arthralgia (CSA), and RA.
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The impact of temporary methotrexate discontinuation for 1 week versus 2 weeks on seasonal influenza vaccination in patients with rheumatoid arthritis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-08-05 Jin Kyun Park, Yun Jong Lee, Kichul Shin, Eun Ha Kang, You-Jung Ha, Jun Won Park, Min Jung Kim, Mi Hyeon Kim, Se Rim Choi, Youjin Jung, Ju Ho Lee, Ji In Jung, Ju Yeon Kim, Kevin L Winthrop, Eun Bong Lee
To determine whether discontinuing methotrexate (MTX) for 1 week after seasonal influenza vaccination is non-inferior to discontinuing for 2 weeks in patients with rheumatoid arthritis (RA).
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Combination of two monoclonal ACPAs induced tenosynovitis, pain and bone loss in mice in a Peptidyl Arginine Deiminase-4 dependent manner Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-08-05 Akilan Krishnamurthy, Alexandra Circiumaru, Jitong Sun, Yogan Kisten, Peter Damberg, Koji Sakuraba, Katalin Sandor, Patrik Jarvoll, Tunhe Zhou, Vivianne Malmström, Camilla I. Svensson, Aase Hensvold, Anca I Catrina, Lars Klareskog, Bence Réthi
The appearance of anti-citrullinated protein antibodies (ACPAs) in the circulation represents a major risk factor for developing rheumatoid arthritis (RA). Patient-derived ACPAs have been shown to induce pain and bone erosion in mice suggesting an active role in the pathogenicity of RA. Here we investigated if ACPAs can induce tenosynovitis, an early sign of RA, in addition to pain and bone loss and
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Nivolumab-induced tracheobronchial chondritis in a patient with hypopharyngeal cancer. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-31 Kazu Hamada-Ode,Yoshinori Taniguchi,Marina Osaki,Rika Yoshimatsu,Noriko Nitta
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Should low serum urate be exonerated? Untangling the influence of sarcopenia in observational studies. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-31 Kanon Jatuworapruk,Nicola Dalbeth
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Nuclear receptor subfamily 4A signaling as a key disease pathway of CD1c+ dendritic cell dysregulation in systemic sclerosis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-31 N.H. Servaas, S. Hiddingh, E. Chouri, C.G.K. Wichers, A.J. Affandi, A. Ottria, C.P.J. Bekker, M. Cossu, S.C. Silva-Cardoso, M. van der Kroef, A.C. Hinrichs, T. Carvalheiro, N. Vazirpanah, L. Beretta, M. Rossato, F. Bonte-Mineur, T.R.D.J. Radstake, J.J.W. Kuiper, M. Boes, A. Pandit
To identify key disease pathways driving conventional dendritic cell (cDC) alterations in Systemic Sclerosis (SSc).
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Spleen tyrosine kinase activation in circulating and tissue innate immune cells in ANCA associated vasculitis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-31 Maria Prendecki, Kavita Gulati, Noelle Pisacano, Damilola Pinheiro, Tejal Bhatt, Marie-Anne Mawhin, Frederic Toulza, Esteban S. Masuda, Andrew Cowburn, Katharine M. Lodge, Frederick W.K. Tam, Candice Roufosse, Charles D. Pusey, Stephen P. McAdoo
Spleen tyrosine kinase (SYK) is a cytoplasmic protein tyrosine kinase which plays a role in signalling via B cell and Fc receptors. Fc receptor engagement and signalling via SYK is thought to be important in anti-neutrophil cytoplasm antibody (ANCA) IgG-mediated neutrophil activation. In this study we investigate the role for SYK in ANCA induced myeloid cell activation and vasculitis pathogenesis.
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Keep an Eye on the Back: Spondyloarthritis in Patients with Acute Anterior Uveitis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-29 Judith Rademacher, Hanna Müllner, Torsten Diekhoff, Hildrun Haibel, Sabrina Igel, Dominika Pohlmann, Fabian Proft, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Uwe Pleyer, Denis Poddubnyy
To analyse the prevalence of spondyloarthritis (SpA) in patients with acute anterior uveitis (AAU), to identify parameters associated with SpA presence, and to evaluate referral algorithms.
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Cyclophilin D regulates NETosis and inflammation in myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-29 Takashi Kudo, Daigo Nakazawa, Kanako Watanabe-Kusunoki, Masatoshi Kanda, Satoka Shiratori-Aso, Nobuya Abe, Saori Nishio, Jun-Ichiro Koga, Sari Iwasaki, Takahiro Tsuji, Yuichiro Fukasawa, Miwako Yamasaki, Masahiko Watanabe, Sakiko Masuda, Utano Tomaru, Masaaki Murakami, Yasuaki Aratani, Akihiro Ishizu, Tatsuya Atsumi
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is pathologically characterized by focal fibrinoid necrosis where ANCA-mediated neutrophil extracellular trap (NET) formation and subsequent endothelial necrosis occurs. Cyclophilin D (CypD) plays an important role in mediating cell necrosis and inflammation via opening of mitochondrial permeability transition pores (mPTP). Here
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Erratum Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-28
In the letter by Wang et al in the June 2022 issue of Arthritis & Rheumatology (Airway Obstruction as a Pulmonary Manifestation of Rheumatoid Arthritis: Comment on the Article by Prisco et al [pages 1095–1096]), the email address for the corresponding author, James Cheng-Chung Wei, MD, PhD, was missing and the authors requested that it be added. Correspondence can be addressed to Dr. Wei's email at jccwei@gmail
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Giant Intraosseous Synovial Cyst with Intraarticular Connection at the Elbow in Rheumatoid Arthritis. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-29 Can M Sungur,Jonathan C Baker
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Subsets of Idiopathic Inflammatory Myositis Enriched for Contemporaneous Cancer Relative to the General Population Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-25 Christopher A. Mecoli, Tak Igusa, Mengkun Chen, Xing Yao Wang, Jemima Albayda, Julie J Paik, Eleni Tiniakou, Brittany Adler, Carrie Richardson, Will Kelly, Sonye Danoff, Andrew L. Mammen, Elizabeth A. Platz, Antony Rosen, Lisa Christopher-Stine, Livia Casciola-Rosen, Ami A. Shah
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Disentangling the Causal Effect of Telomere Length in Systemic Lupus Erythematosus Using Genetic Variants as Instruments. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-25 Yiqiang Zhan,Xiaoying Kang
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Artificial Intelligence and Deep Learning for Rheumatologists: A Primer and Review of the Literature Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-20 Christopher McMaster, Alix Bird, David FL Liew, Russell R Buchanan, Claire E Owen, Wendy W Chapman, Douglas EV Pires
Deep Learning has emerged as the leading method in machine learning, spawning a rapidly-growing field of academic research and commercial applications across medicine, and could have particular relevance to rheumatology if utilized correctly. The greatest benefits of deep learning methods are seen with the unstructured data frequently found in rheumatology, such as images and text, where traditional
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Synovial inflammatory pathways characterize anti-TNF-responsive rheumatoid arthritis patients Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-19 Jing Wang, Donna Conlon, Felice Rivellese, Alessandra Nerviani, Myles J. Lewis, William Housley, Marc C. Levesque, Xiaohong Cao, Carolyn Cuff, Andrew Long, Costantino Pitzalis, Melanie C. Ruzek
This study was undertaken to understand the mechanistic basis of response to anti-TNF therapies and determine if transcriptomic changes in the synovium are reflected in peripheral protein markers.
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Epigenetic regulation of profibrotic macrophages in systemic sclerosis- associated interstitial lung disease Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-18 Anna Papazoglou, Mengqi Huang, Melissa Bulik, Annika Lafyatis, Tracy Tabib, Christina Morse, John Sembrat, Mauricio Rojas, Eleanor Valenzi, Robert Lafyatis
Systemic sclerosis-associated interstitial lung Disease (SSc-ILD) is the leading cause of death in patients with systemic sclerosis (SSc) with unclear pathogenesis and limited treatment options. Evidence strongly supports an important role for profibrotic, SPP1-expressing macrophages in SSc-ILD. We sought to define the transcriptome and chromatin structural changes of SPP1 SSc-ILD macrophages, so as
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Identification of three different phenotypes in anti-MDA5 antibody-positive dermatomyositis patients: implications for rapidly progressive interstitial lung disease prediction Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-18 Lingxiao Xu, Hanxiao You, Lei Wang, Chengyin Lv, Fenghong Yuan, Ju Li, Min Wu, Zhanyun Da, Hua Wei, Wei Yan, Lei Zhou, Songlou Yin, Dongmei Zhou, Jian Wu, Yan Lu, Dinglei Su, Zhichun Liu, Lin Liu, Longxin Ma, Xiaoyan Xu, Yinshan Zang, Huijie Liu, Tianli Ren, Fang Wang, Yan Du, Jing Xue, Miaojia Zhang, Wenfeng Tan
Substantial phenotypic heterogeneity exists in anti-melanoma differentiation-associated gene 5 antibody-positive (anti-MDA5+) dermatomyositis patients, hindering disease assessment and management. This study aimed to identify distinct phenotypic groups in anti-MDA5+ patients and determine their utility in outcome prediction.
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Safety and Efficacy of Bimekizumab in Patients with Active Ankylosing Spondylitis: 3-Year Results from a Phase 2b Randomized Controlled Trial and its Open-Label Extension Study Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-13 Xenofon Baraliakos, Atul Deodhar, Maxime Dougados, Lianne S. Gensler, Anna Molto, Sofia Ramiro, Alan J. Kivitz, Denis Poddubnyy, Marga Oortgiesen, Thomas Vaux, Carmen Fleurinck, Julie Shepherd-Smith, Christine de la Loge, Natasha de Peyrecave, Désirée van der Heijde
Video Abstract
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Telomere length and development of systemic lupus erythematosus: a Mendelian randomization study Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-13 Xu-Fan Wang, Wen-Jing Xu, Fei-Fei Wang, Rui Leng, Xiao-Ke Yang, Hua-Zhi Ling, Yin-Guang Fan, Jin-Hui Tao, Zong-Wen Shuai, Li Zhang, Dong-Qing Ye, Rui-Xue Leng
Previous observational studies demonstrated that a subset of patients with systemic lupus erythematosus (SLE) have markedly short telomere length (TL) in leukocytes. The purpose of this study is to test whether leukocyte TL is causally associated with risk of SLE.
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Safety and Efficacy of Bimekizumab in Patients with Active Psoriatic Arthritis: 3-Year Results from a Phase 2b Randomized Controlled Trial and its Open-Label Extension Study Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-13 Laura C. Coates, Iain B. McInnes, Joseph F. Merola, Richard B. Warren, Arthur Kavanaugh, Alice B. Gottlieb, Laure Gossec, Deepak Assudani, Rajan Bajracharya, Jason Coarse, Barbara Ink, Christopher T. Ritchlin
To assess long-term safety, tolerability, and efficacy of bimekizumab in active psoriatic arthritis (PsA).
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Walking Associates with Improved Symptom and Structure Outcomes for Knee Osteoarthritis. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-18 Grace H Lo,Jeffrey B Driban
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Walking for exercise and subsequent changes of clinical outcomes in patients with knee osteoarthritis: Comment on the article by Lo et al. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-18 Tomoyuki Kawada
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Assessing the immune cell subset and genetic mutations in palindromic rheumatism negative for rheumatoid factor and anti-citrullinated antibodies Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-12 Chin-An Yang, Ju-Pi Li, Yi-Hua Lai, Ya-Ling Huang, Chien-Yu Lin, Joung-Liang Lan
The etiology underlying rheumatoid factor and anti-CCP-negative palindromic rheumatism not associated with other rheumatic diseases (seronegative PR) is unclear. We aimed to investigate the immune cells and genes involved.
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Dysregulation of bile acids, lipids, and nucleotides in psoriatic arthritis revealed by unbiased profiling of serum metabolites Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-11 Ananta Paine, Paul S. Brookes, Soumyaroop Bhattacharya, Dongmei Li, Maria De La Luz Garcia-Hernandez, Francisco Tausk, Christopher Ritchlin
The transition from psoriasis (Ps) to psoriatic arthritis (PsA) occurs in 20-30% patients, however, the mechanisms underlying the emergence of musculoskeletal disease are not well understood. Metabolic disease is prevalent in Ps patients, but whether metabolic factors, other than obesity, increase arthritis risk in Ps patients is not known.
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Smartphone-Assisted Patient-Initiated Care Versus Usual care in Patients With Rheumatoid Arthritis and Low Disease Activity: a Randomized Controlled Trial Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-11 BF Seppen, J Wiegel, MM Ter Wee, D Schaardenburg, LD Roorda, MT Nurmohamed, M Boers, WH Bos
We developed a smartphone app for patients with rheumatoid arthritis (RA), which allows them to self-monitor their disease activity in between clinic visits by answering a weekly routine assessment of patient index data (RAPID-3). The objective of this study was to assess safety (non-inferiority in disease activity score 28, DAS28) and efficacy (reduction in number of visits) of patient-initiated care
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Both disease activity and HLA-B27 determine gut microbiome dysbiosis in spondyloarthritis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-11 Magali Berland, Victoria Meslier, Samar Berreira Ibraim, Emmanuelle Le Chatelier, Nicolas Pons, Nicolas Maziers, Florence Thirion, Franck Gauthier, Florian Plaza Oñate, Jean-Pierre Furet, Ariane Leboime, Roula Said-Nahal, Florence Levenez, Nathalie Galleron, Benoît Quinquis, Philippe Langella, Stanislav Dusko Ehrlich, Maxime Breban
Gut microbiome dysbiosis has previously been reported in spondyloarthritis (SpA) and could critically be involved in the pathogenesis of this disorder. The objective of this study was to further characterize the microbiota structure in SpA patients and to investigate the relationship between dysbiosis and disease activity, in light of the putative influence of genetic background.
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Concepts of entheseal pain Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-11 Enrico De Lorenzis, Gerlando Natalello, David Simon, Georg Schett, Maria Antonietta D'Agostino
Pain is the main symptom of entheseal diseases (enthesopathies) despite a paucity of nerve endings in the enthesis itself. Eicosanoids, cytokines, and neuropeptides released during inflammatory and repeated non-physiological mechanical challenge not only stimulate or sensitize primary afferent neurons present in structures adjacent to the enthesis or but also trigger a “neuro-vascular invasion” that
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PI3 kinase delta deficiency protects from anti-myeloperoxidase vasculitis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-11 Fernanda Flórez-Barrós, Simon Freeley, El li Tham, Michael G Robson
Anti-neutrophil cytoplasmic antibody vasculitis is a systemic autoimmune disease in which glomerulonephritis is an important manifestation. Antibodies against myeloperoxidase or proteinase 3 are thought to be important in pathogenesis. Phosphoinositide 3-kinase delta mediates a number of effects in lymphocytes but its role in myeloid cell responses is less clear. Therefore, we assessed this in a preclinical
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SARS-CoV-2 immune responses in B cell depleted patients with autoimmune disease. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-12 Georg Schett,David Simon,Filippo Fagni,Korey Tascilar
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Systemic glucocorticoids confound SARS-CoV-2 acquisition or even clinical outcomes in autoimmune disease patients treated with biologics. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-12 Man-Man Niu,Qi Jiang,Yan-Fang Zhang,Dao-Ting Li,Qian Yang,Peng Hu
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Reply to the letter: Optimal bridging strategy in active early rheumatoid arthritis: A bridge falling short? Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-12 Dietmar Krause,Juergen Braun
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Optimal bridging strategy in active early rheumatoid arthritis: A bridge falling short ? Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-11 Joydeep Samanta,Alekhya Amudalapalli,Ashlesha Shukla,Harish Bv,Sudhish Gadde,Rasmi R Sahoo,Pradeepta S Patro
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Superiority of low-dose benzbromarone to low-dose febuxostat in a prospective, randomized comparative effectiveness trial in gout patients with renal uric acid underexcretion Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-07 Fei Yan, Xiaomei Xue, Jie Lu, Nicola Dalbeth, Han Qi, Qing Yu, Can Wang, Mingshu Sun, Lingling Cui, Zhen Liu, Yuwei He, Xuan Yuan, Ying Chen, Xiaoyu Cheng, Lidan Ma, Hailong Li, Aichang Ji, Shuhui Hu, Zijing Ran, Robert Terkeltaub, Changgui Li
The predominant mechanism driving hyperuricemia in gout is renal uric acid underexcretion, yet the standard urate-lowering therapy (ULT) recommendation is first line xanthine oxidase inhibition (XOI) irrespective of the cause of hyperuricemia. Here, we conducted a comparative effectiveness clinical trial of first line un-titrated, low-dose benzbromarone uricosuric therapy vs. XOI ULT with low-dose
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Breakthrough SARS-CoV-2 infections in immune mediated disease patients undergoing B cell depleting therapy: A retrospective cohort analysis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-06 Cassandra M Calabrese, Elizabeth Kirchner, Elaine M Husni, Brandon P Moss, Anthony P Fernandez, Yuxuan Jin, Leonard H Calabrese
Patients with immune mediated inflammatory diseases (IMIDs) receiving B cell depleting therapy (BCDT) are among the most vulnerable to severe COVID-19 as well as the most likely to respond sub-optimally to SARS-CoV-2 vaccines. However, little is known about the frequency or severity of breakthrough infection in this population. We retrospectively analyzed a large group of vaccinated IMIDs patients
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Contribution of microRNA-27b-3p to synovial fibrotic responses in knee osteoarthritis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-06 Ghazaleh Tavallaee, Starlee Lively, Jason S. Rockel, Shabana Amanda Ali, Michelle Im, Clementine Sarda, Greniqueca M. Mitchell, Evgeny Rossomacha, Sayaka Nakamura, Pratibha Potla, Sarah Gabrial, John Matelski, Anusha Ratneswaran, Kim Perry, Boris Hinz, Rajiv Gandhi, Igor Jurisica, Mohit Kapoor
Synovial fibrosis contributes to osteoarthritis (OA) pathology but the underlying mechanisms remain unknown. We have observed increased microRNA (miR)-27b-3p levels in synovial fluid of late-stage radiographic knee OA patients. Here, we determined the contribution of miR-27b-3p to synovial fibrosis.
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Modulation of the itaconate pathway attenuates murine lupus Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-06 Luz P. Blanco, Eduardo Patino-Martinez, Shuichiro Nakabo, Mingzeng Zhang, Hege L. Pedersen, Xinghao Wang, Carmelo Carmona Rivera, Dillon Claybaugh, Zu-Xi Yu, Equar Desta, Mariana J. Kaplan
Itaconic acid, a Kreb's cycle derived immunometabolite, is synthesized by myeloid cells in response to danger signals to control inflammasome activation, type I Interferon (IFN) responses and oxidative stress. As these pathways are dysregulated in systemic lupus erythematosus (SLE), we investigated the role of an itaconic acid derivative in the treatment of established murine lupus.
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Association of 18F-Fluorodeoxyglucose Positron Emission Tomography and Angiographic Progression of Disease in Large-Vessel Vasculitis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-06 Kaitlin A. Quinn, Mark A. Ahlman, Hugh D. Alessi, Michael P. LaValley, Tuhina Neogi, Jamie Marko, Elaine Novakovich, Peter C. Grayson
To assess whether vascular FDG-PET activity is associated with angiographic change in large-vessel vasculitis (LVV).
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Duloxetine and Osteoarthritis: There is a herd of elephant in the room. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-06 Alain Braillon
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Response to the study by van den Driest, et al published in Arthritis and Rheumatology. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-07-06 Joel A Block,Theodore Pincus
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RNA-Seq analysis identifies alterations of the primary cilia gene SPAG17 and SOX9 locus non-coding RNAs in systemic sclerosis Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-28 Elisha D.O. Roberson, Mary Carns, Li Cao, Kathleen Aren, Isaac A. Goldberg, David J. Morales-Heil, Benjamin D. Korman, John P. Atkinson, John Varga
Systemic sclerosis (SSc) is characterized by immune activation, vasculopathy, and unresolving fibrosis in the skin, lungs, and other organs. We performed RNA-Seq analysis on skin biopsies and peripheral blood mononuclear cells (PBMCs) from SSc patients and controls to better understand SSc pathogenesis.
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Response to Nelson et al letter to the editor. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-28 Charles B Eaton,Tim McAlindon,Jeffrey Driban
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Imaging mass cytometry reveals predominant innate immune signature and endothelial-immune cell interaction in juvenile myositis compared to lupus skin. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-28 Jessica L Turnier,Christine M Yee,Jacqueline A Madison,Syed M Rizvi,Celine C Berthier,Fei Wen,J Michelle Kahlenberg
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The Climate Emergency and the Health of Our Patients: The Role of the Rheumatologist. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-28 Paul F Dellaripa,Thomas Bush,Frederick W Miller,Candace H Feldman
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Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis. Comment on the article by Rosine et al. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-28 Eric Toussirot,Caroline Laheurte,Philippe Saas
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The prevalence of hand osteoarthritis: Comment on the article by Eaton et al. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-28 Amanda E Nelson,Todd A Schwartz,Carolina Alvarez,Yvonne M Golightly
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The relation of pain reduction with prevention of knee replacement under dynamic intervention strategies Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-20 S. Reza Jafarzadeh, Tuhina Neogi, Daniel K. White, David T. Felson
Knee replacement rates are increasing exponentially in the US and straining insurance budgets. We investigated how many knee replacements (KRs) would be prevented at different levels of pain improvement, a major target of osteoarthritis trials.
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Variability in primary Sjögren's syndrome is driven by interferon alpha, and genetically associated with the class II HLA DQ locus Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-20 Diana Trutschel, Pierre Bost, Xavier Mariette, Vincent Bondet, Alba Llibre, Celine Posseme, Bruno Charbit, Christian W. Thorball, Roland Jonsson, Christopher J. Lessard, Renaud Felten, Wan Fai Ng, Lucienne Chatenoud, Hélène Dumortier, Jean Sibilia, Jacques Fellay, Karl A. Brokstad, Silke Appel, Jessica R Tarn Dr, Lluis Quintana Murci, Michael Mingueneau, Nicolas Meyer, Darragh Duffy, Benno Schwikowski
Primary Sjögren's syndrome (pSS) is the second most frequent systemic autoimmune disease affecting 0.1% of the general population. To characterize the molecular and clinical variability across pSS patients, we integrated transcriptomic, proteomic, cellular and genetic data with clinical phenotypes in a cohort of 351 pSS patients.
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2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-20 Susan M. Goodman, Bryan D. Springer, Antonia F. Chen, Marshall Davis, David R. Fernandez, Mark Figgie, Heather Finlayson, Michael D. George, Jon T. Giles, Jeremy Gilliland, Brian Klatt, Ronald MacKenzie, Kaleb Michaud, Andy Miller, Linda Russell, Alexander Sah, Matthew P. Abdel, Beverly Johnson, Lisa A. Mandl, Peter Sculco, Marat Turgunbaev, Amy S. Turner, Adolph Yates, Jasvinder A. Singh
To develop updated guidelines for the perioperative management of disease-modifying medications for patients with rheumatic diseases, specifically those with inflammatory arthritis (IA) and those with systemic lupus erythematosus (SLE), undergoing elective total hip arthroplasty (THA) or elective total knee arthroplasty (TKA).
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Combined genetic deficiencies of the classical complement pathway are strongly associated with both systemic lupus erythematosus and primary Sjögren's syndrome Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-21 Christian Lundtoft, Christopher Sjöwall, Solbritt Rantapää-Dahlqvist, Anders A. Bengtsson, Andreas Jönsen, Pascal Pucholt, Yee Ling Wu, Emeli Lundström, Maija-Leena Eloranta, Iva Gunnarsson, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad-d'Elia, Per Eriksson, Thomas Mandl, Sara Bucher, Katrine B. Norheim, Svein Joar Auglænd Johnsen, Roald Omdal, Marika Kvarnström, Marie Wahren-Herlenius
Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of SLE or primary Sjögren's syndrome (pSS) has not been studied systematically. Here we investigated heterozygous C2 deficiency and C4 copy number variation in relation to clinical manifestations in SLE and pSS.
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Phase II/III results of the anti-TNF multivalent NANOBODY® compound ‘ozoralizumab’ in patient with rheumatoid arthritis (OHZORA trial) Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-21 Tsutomu Takeuchi, Masafumi Kawanishi, Megumi Nakanishi, Hironori Yamasaki, Yoshiya Tanaka
This study aimed to assess the efficacy and safety of subcutaneous administration of ozoralizumab 30 mg or 80 mg + methotrexate (MTX) in patients with active rheumatoid arthritis (RA), despite MTX therapy.
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Reply: A misinformative title and an abstract conclusion in the recent GWAS study in Behçet's Disease: Comment on the article by Su et al. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-20 Guannan Su,Peizeng Yang
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Two Distinct Immune Cell Signatures Predict the Clinical Outcomes in Patients with Amyopathic Dermatomyositis with Interstitial Lung Disease Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-17 Yan Ye, Xueliang Zhang, Teng Li, Jiaqiang Ma, Ran Wang, Chunmei Wu, Runci Wang, Chunde Bao, Shuang Ye, Nan Shen, Qiang Guo, Qiong Fu, Xiaoming Zhang
Amyopathic dermatomyositis (ADM) is a heterogeneous and life-threatening autoimmune disease with high mortality. In particular, anti-MDA5 antibody-positive patients are at high risk of developing rapidly progressive interstitial lung disease (ILD). This study aimed to identify immunological signatures among ADM-ILD patients and discover the biomarkers predicting prognosis.
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A methodological problem and a conceptual issue related to the new 2022 ANCA related vasculitis criteria sets. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-17 Hasan Yazici,Yusuf Yazici
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Response to Letter to the Editor by Drs. Yazici and Yazici regarding the 2022 ACR/EULAR Classification Criteria for the ANCA-associated vasculitides. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-17 Peter C Grayson,Cristina Ponte,Joanna C Robson,Ravi Suppiah,Anthea Craven,Andrew Judge,Sara Khalid,Andrew Hutchings,Richard A Watts,Raashid A Luqmani,Peter A Merkel
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Immune Cell Signatures to Stratify Patients with Systemic Autoimmune Diseases: a Step Towards Individualized Medicine? Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-17 Takahisa Gono,Divi Cornec
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Notes from the Field: VEXAS Syndrome and Disease Taxonomy in Rheumatology. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-13 Peter C Grayson,David B Beck,Marcela A Ferrada,Peter A Nigrovic,Daniel L Kastner
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Transforming rheumatology practice with technology - products, processes, people, and purpose. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-13 Rebecca Grainger
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VEXAS syndrome presenting as treatment-refractory polyarteritis nodosa. Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-13 Masaki Itagane,Hiroyuki Teruya,Tomohiro Kato,Naomi Tsuchida,Ayaka Maeda,Yuri Uchiyama,Yohei Kirino,Naomichi Matsumoto,Mitsuyo Kinjo
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Association Between Walking for Exercise and Symptomatic and Structural Progression in Individuals with Knee Osteoarthritis: Data from the Osteoarthritis Initiative Cohort Arthritis Rheumatol. (IF 15.483) Pub Date : 2022-06-08 Grace H. Lo, Surabhi Vinod, Michael J. Richard, Matthew S. Harkey, Timothy E. McAlindon, Andrea M. Kriska, Bonny Rockette-Wagner, Charles B. Eaton, Marc C. Hochberg, Rebecca D. Jackson, C. Kent Kwoh, Michael C. Nevitt, Jeffrey B. Driban
To assess the relationship between walking for exercise and symptomatic and structural progression in those with knee osteoarthritis.