Arthritis associated with immune checkpoint inhibitor (ICI) therapies highlights the importance of immune checkpoint expression for joint homeostasis. We investigated the role of programmed death ligand 1 (PD-L1) in the synovium using collagen-induced arthritis (CIA) mouse model.

To analyze the impact of amino acid (AA) availability on the inflammatory response in arthritis.

Systemic lupus erythematosus (SLE), a multi-organ systemic inflammatory disorder, predominantly affects women during their reproductive years. In this review, we summarize the state of knowledge about pre-conception planning and management of SLE during pregnancy. Achieving remission or low disease activity for several months on medications compatible with pregnancy prior to conception is essential

Women with psoriatic arthritis (PsA) may have reduced tumor necrosis factor inhibitor (TNFi) effectiveness compared to men. We examined sex differences in treatment response and retention rates during 24 months of follow-up among patients with PsA initiating their first TNFi.

Chronic Fatigue is a major clinical unmet need among patients with Rheumatoid Arthritis (RA). Current therapies are limited to non-pharmacological interventions, such as personalised exercise programmes (PEP) and cognitive behavioural approaches (CBA), however, still most patients continue to report severe fatigue. To inform more effective therapies, we conducted an MRI brain study of PEP and CBA,

To compare the vertical (vGRF), anterior-posterior (apGRF) and medial-lateral (mlGRF) ground reaction force (GRF) profiles throughout the stance phase of gait: 1) between individuals 6-12 months post anterior cruciate ligament reconstruction (ACLR) and uninjured matched controls; and 2) between ACLR and individuals with differing radiographic severities of knee osteoarthritis (KOA) defined as Kellgren

The peripheral B cell compartment is heavily disturbed in systemic lupus erythematosus (SLE), but whether B cells develop aberrantly in the bone marrow (BM) is largely unknown.

To assess the clinical and structural impact at 2 years of progressively spacing tocilizumab (TCZ) or abatacept (ABA) injections versus maintenance at full dose in rheumatoid arthritis (RA) patients in sustained remission.

Even though systemic vasculitides (SV) affect primarily patients over 50 years of age, they can occur among women of childbearing age. Preterm birth (PTB) and hypertensive disorders are frequent complications of pregnancy in SV. This study aims to evaluate the risk of hypertensive disorders and PTB amongst pregnant women with SV, and to identify associated risk factors.

Giant cell arteritis (GCA) is an age-related vasculitis. Prior studies have identified an association between GCA and hematologic malignancies (HM). How the presence of somatic mutations which drive development of HM, or clonal hematopoiesis (CH), may influence clinical outcomes in GCA is not well understood.

To assess the quality of LLM–chatbot vs. physician-generated responses to patient–generated rheumatology questions.

To evaluate the relationship of a history of strength training with symptomatic and structural outcomes of knee osteoarthritis (OA).

Using trial data comparing treat-to-target allopurinol and febuxostat in gout, we examined participant characteristics associated with serum urate (SU) goal achievement.

The objective is to update recommendations for prevention and treatment of glucocorticoid-induced osteoporosis (GIOP) for patients with rheumatic or nonrheumatic conditions receiving >3 months treatment with glucocorticoids (GCs) ≥2.5 mg daily.

Recent studies have uncovered diverse cell types/states in the RA synovium; however limited data exist correlating these findings with patient-level clinical information. Using the largest cohort to date with clinical and multi-cell data, we determined associations between RA clinical factors with cell types/states in the RA synovium.

To evaluate the diagnostic accuracy of the labial salivary gland biopsy based on multiple histopathological features in patients with suspected primary Sjögren's syndrome (pSS).

To develop evidence-based consensus recommendations for the optimal timing of hip and knee arthroplasty to improve patient-important outcomes including, but not limited to, pain, function, infection, hospitalization, and death at 1 year for patients with symptomatic and radiographic moderate-to-severe osteoarthritis or advanced symptomatic osteonecrosis with secondary arthritis of the hip or knee who

We are grateful for the constructive engagement with our article from Xie et al,1 Lin et al,2 and Wang et al3 and have the following comments to their questions and concerns. Xie et al raise concerns regarding the potential influence of drug use on our study results.1 We examined this aspect by adjusting for treatment categorized into groups of specific disease-modifying antirheumatic drugs, which

Fibromyalgia (FM) is characterized by pervasive pain-related symptomatology and high levels of negative affect. Mind–body treatments such as cognitive behavioral therapy (CBT) appear to foster improvement in FM via reductions in pain-related catastrophizing, a set of negative, pain-amplifying cognitive and emotional processes. However, the neural underpinnings of CBT's catastrophizing-reducing effects

To compare the genetic contribution to osteoarthritis (OA) vs other rheumatic/musculoskeletal diseases (RMDs) in the same population, and 2) to explore the role for any shared genetics between OA and other RMDs.

To assess efficacy, safety, and tolerability of canakinumab in patients with tumor necrosis factor receptor-associated periodic syndrome (TRAPS) during a 72-week long-term, open-label extension of the CLUSTER study.

Juvenile-onset fibromyalgia (JFM) is a paradigmatic chronic pain condition for which the underlying neurobiological substrates are poorly understood. This study examined for the first time data-driven resting-state functional connectivity (rsFC) alterations in 37 female adolescents with JFM compared with 43 healthy female adolescents, and identified associations with bodily pain.

In the article by Faber et al in the June 2023 issue of Arthritis & Rheumatology (A Genome-Wide Association Study Meta-Analysis of Alpha Angle Suggests Cam-Type Morphology May Be a Specific Feature of Hip Osteoarthritis in Older Adults, https://onlinelibrary.wiley.com/doi/10.1002/art.42451), the authors’ funding statement in the title page footnotes contains some errors. The following corrections are

We read with interest the article by Materne et al (1) that reported on the risks of serious infection in patients with nonrenal lupus treated with belimumab versus standard immunosuppressive treatment, using a hypothetical target trial and including over 2500 belimumab-treated patients. The findings are in keeping with data from our UK systemic lupus erythematosus (SLE) biologics register, the BILAG-BR

To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR.

Adult skeletal stem cells (SSC) give rise to chondrocytes, osteocytes and stromal cells as progeny have been shown to contribute to cartilage regeneration in Osteoarthritis (OA). Understanding extrinsic and intrinsic regulators of SSC fate and function can therefore identify putative candidate factors to enhance cartilage regeneration. This study explores how the DNA hydroxymethylase, TET1 regulates

Thrombotic microangiopathy (TMA) refers to a diverse group of diseases which share clinical and histopathologic features. TMA is clinically characterized by microangiopathic hemolytic anemia (MAHA), consumptive thrombocytopenia, and organ injury which stems from endothelial damage and vascular occlusion. There are several disease states with distinct pathophysiological mechanisms that manifest as TMA

B cells are important in the pathogenesis of primary Sjögren's syndrome (pSS). Patients positive for SSA/SSB autoantibodies are more prone to systemic disease manifestations and adverse outcomes. We aimed to determine the role of B cell composition, gene expression and B cell receptor (BCR) usage in pSS subgroups stratified for SSA/SSB antibodies.