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Myeloablation followed by hematopoietic stem cell transplantation leads to long-term normalization of systemic sclerosis molecular signatures Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-03-18 Nancy Wareing, Xuan Wang, Lynette Keyes-Elstein, Ellen A. Goldmuntz, Marka A. Lyons, Peter McSweeney, Daniel E. Furst, Richard A. Nash, Leslie J. Crofford, Beverly Welch, Ashley Pinckney, Maureen D. Mayes, Keith M. Sullivan, Shervin Assassi
In the randomized Scleroderma: Cyclophosphamide Or Transplantation (SCOT trial), myeloablation, followed by hematopoietic stem cell transplantation (HSCT), led to normalization of systemic sclerosis (SSc) peripheral blood gene cell (PBC) expression signature at the 26-month visit. Herein, we examined long-term molecular changes ensuing 54 months after randomization for individuals receiving an HSCT
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The risk of relapse of ANCA-associated vasculitis in a randomized controlled trial of plasma exchange and glucocorticoids Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-03-14 Mats L Junek, Peter A Merkel, Eswari Vilayur, Ron Wald, Nader Khalidi, David Jayne, Michael Walsh
Relapses of ANCA-associated vasculitis are important events that can cause organ dysfunction and reduce quality of life. Understanding the effects of the initial treatments for ANCA-associated vasculitis on the subsequent risk of relapse may help guide monitoring and treatment.
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Risk of Venous Thromboembolism with Tofacitinib Versus Tumor Necrosis Factor Inhibitors in Cardiovascular Risk‐enriched Rheumatoid Arthritis Patients Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-03-14 Christina Charles‐Schoeman, Roy Fleischmann, Eduardo Mysler, Maria Greenwald, Steven R. Ytterberg, Gary G. Koch, Deepak L. Bhatt, Cunshan Wang, Ted R. Mikuls, All‐shine Chen, Carol A. Connell, John C. Woolcott, Sujatha Menon, Yan Chen, Kristen Lee, Zoltán Szekanecz
ObjectiveThe ORAL Surveillance trial found a dose‐dependent increase in venous thromboembolism (VTE) and pulmonary embolism (PE) events with tofacitinib versus tumor necrosis factor inhibitors (TNFi). We aimed to assess VTE incidence over time and explore risk factors of VTE, including disease activity, in ORAL Surveillance.MethodsPatients with rheumatoid arthritis (RA) aged ≥50 years with ≥1 additional
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LAMP3 induces ectopic TLR7 expression in salivary gland epithelial cells and amplifies type I IFN production in Sjögren's disease Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-03-13 Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A. Afione, Tatsuya Atsumi, Masayuki Noguchi, Fabiola Reis Oliveira, Ana Carolina F. Motta, Fernando Chahud, Eduardo M. Rocha, Blake M. Warner, John A. Chiorini
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Nasal Rim Sign: A clinical manifestation of dermatomyositis Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-03-05 Sweta Subhadarshani, Madeline Hunt, Kerith Spicknall
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Genetic Approaches to Study Rheumatic Diseases and its Implications in Clinical Practice Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-03-04 Dorota Rowczenio, Ivona Aksentijevich
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Phosphatidic acid promotes the generation of IL‐17A producing double‐negative T cell by enhancing mTORC1 signaling in lupus Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-03-04 Wenjing Li, Xiaojun Tang, Yuanyuan Zheng, Xuefeng Xu, Nan Zhao, Betty P. Tsao, Xuebing Feng, Lingyun Sun
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Changes in the Workforce Characteristics of Providers who Care for Adult Patients with Rheumatologic and Musculoskeletal Disease in the United States Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-25 Melissa L Mannion, Fenglong Xie, John D FitzGerald, Amanda Alexander, Amy Mudano, Yujie Su, Kenneth G. Saag, Jeffrey R Curtis
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Muscle quality is associated with pain in adults with symptomatic knee osteoarthritis, independent of muscle strength: Findings from the MyCA study. Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-25 Alisa J. Johnson, Sarah M. Barron, Jennifer A. Nichols, Yenisel Cruz-Almeida
Knee osteoarthritis (OA) is a leading cause of chronic pain in adults and shows wide inter-individual variability, with peripheral and central factors contributing to the pain experience. Periarticular factors such as muscle quality (e.g., echo intensity and shear wave velocity) may contribute to knee OA pain; however, the role of muscle quality in OA symptoms has yet to be fully established.
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Expansion of HLA‐DR+ Peripheral Helper T and Naïve B cells in Anti‐Citrullinated Protein Antibody‐Positive Subjects At‐Risk for Rheumatoid Arthritis Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-27 Hideto Takada, M. Kristen Demoruelle, Kevin D. Deane, Shohei Nakamura, Yasuhiro Katsumata, Katsunori Ikari, Jane H. Buckner, William H. Robinson, Jennifer A. Seifert, Marie L. Feser, LauraKay Moss, Jill M. Norris, Masayoshi Harigai, Elena W.Y. Hsieh, V. Michael Holers, Yuko Okamoto
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Hyperuricemia subtypes classified according to renal uric acid handling manifest distinct phenotypic and genetic profiles in people with gout Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-27 Han Qi, Mingshu Sun, Robert Terkeltaub, Tony R. Merriman, Haibing Chen, Zhiqiang Li, Aichang Ji, Xiaomei Xue, Wenyan Sun, Can Wang, Xinde Li, Yuwei He, Lingling Cui, Nicola Dalbeth, Changgui Li
ObjectiveHyperuricemia can be stratified into four subtypes according to renal uric acid handling. The aim of this study was to comprehensively describe the biological characteristics (including genetic background) of clinically defined hyperuricemia subtypes in two large geographically independent gout cohorts.MethodsHyperuricemia subtype was defined as renal uric acid overload (ROL), renal underexcretion
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Introducing the Office of Autoimmune Disease Research Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-26 Victoria K. Shanmugam, Janine A. Clayton
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A diagnostic performance study of the 2023 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for patients with antiphospholipid syndrome from the Antiphospholipid Syndrome Chinese Collaborative cohort presenting with suspected antiphospholipid syndrome Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-25 Qingyi Lu, Yuzhou Gan, Zhongqiang Yao, Chun Li
The 2023 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) antiphospholipid syndrome (APS) classification criteria incorporate more clinical items and use weighted items with the aim of classifying APS with increased specificity.1 The new criteria has been validated in two cohorts, but none of the patients and centers are from Asian populations. To evaluate
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Intra‐Articular Mineralization on Knee CT and Risk of Cartilage Damage: The Multicenter Osteoarthritis Study Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-19 Jean W. Liew, Mohammed Jarraya, Ali Guermazi, David Felson, Michael Nevitt, Cora E. Lewis, James Torner, Frank W. Roemer, Michel D. Crema, Na Wang, Gabriela Rabasa, Fabio Becce, Tristan Pascart, Tuhina Neogi
OBJECTIVESIntra‐articular (IA) mineralization may contribute to OA structural progression. We studied the association of IA mineralization on knee CT with cartilage damage worsening on knee MRI, with a focus on location‐ and tissue‐specific effects.METHODSParticipants from the Multicenter Osteoarthritis study with knee CTs and MRIs were included. Presence of IA mineralization on CT was defined as a
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A multilayered post‐GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE) Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-19 Mehdi Fazel‐Najafabadi, Loren L. Looger, Harikrishna Reddy Rallabandi, Swapan K. Nath
ObjectivesSystemic lupus erythematosus (SLE), an autoimmune disease with incompletely understood etiology, has a strong genetic component. Although genome‐wide association studies (GWAS) have revealed multiple SLE susceptibility loci and associated single nucleotide polymorphisms (SNPs), the precise causal variants, target genes, cell types, tissues, and mechanisms of action remain largely unknown
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Effect of Intravenous Zoledronic Acid on Total Knee Replacement in Patients With Symptomatic Knee Osteoarthritis and Without Severe Joint Space Narrowing: A Prespecified Secondary Analysis of a Two-Year, Multicenter, Double-Blind, Placebo-Controlled Clinical Trial Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-18 Guoqi Cai, Laura L. Laslett, Michael Thompson, Flavia Cicuttini, Catherine Hill, Anita E. Wluka, Lyn March, Yuanyuan Wang, Petr Otahal, James D. Stoney, Benny Antony, Kathy Buttigieg, Tania Winzenberg, Graeme Jones, Dawn Aitken
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A Novel human IL-23A Overexpressing Mouse Model of Systemic Lupus Erythematosus Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-15 Eleni Christodoulou-Vafeiadou, Christina Geka, Lida Iliopoulou, Lydia Ntari, Maria C. Denis, Niki Karagianni, George Kollias
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Clinical Characteristics and Outcomes of Polyarteritis Nodosa: An International Study Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-12 Omer Karadag, Ertugrul Cagri Bolek, Gizem Ayan, Aladdin J. Mohammad, Peter C. Grayson, Christian Pagnoux, Eduardo Martín-Nares, Sara Monti, Yoshiyuki Abe, Federico Alberici, Fatma Alibaz-Oner, David Cuthbertson, Lorenzo Dagna, Haner Direskeneli, Nader A. Khalidi, Curry Koening, Carol A. Langford, Carol A. McAlear, Paul A. Monach, Luca Moroni, Roberto Padoan, Phillip Seo, Kenneth J. Warrington, Alojzija
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Using Two Predictive Models to Capture Two Types of Poor Outcomes in Knee Arthroplasty: A Multisite Longitudinal Cohort Study Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-02-07 Daniel L. Riddle, Levent Dumenci
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CCL19-positive lymph node stromal cells govern the onset of inflammatory arthritis via tropomyosin receptor kinase Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-25 Fabian Schälter, Vugar Azizov, Michael Frech, Kerstin Dürholz, Eva Schmid, Anna Hendel, Ilann Sarfati, Yuichi Maeda, Maria Sokolova, Ippei Miyagawa, Kristin Focke, Kerstin Sarter, Lisa G M van Baarsen, Stefan Krautwald, Georg Schett, Mario M. Zaiss
To assess the role of CCL19+ lymph node stromal cells of the joint draining popliteal lymph node (pLN) for the development of arthritis.
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Effect of Recent Antirheumatic Drug on Features of Rheumatoid Arthritis–Associated Lymphoproliferative Disorders Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-25 Yoshihiko Hoshida, Atsuko Tsujii, Shiro Ohshima, Yukihiko Saeki, Masato Yagita, Tomoya Miyamura, Masao Katayama, Tomonori Kawasaki, Yasushi Hiramatsu, Hisaji Oshima, Toshihiko Murayama, Shinji Higa, Kazuya Kuraoka, Fuminori Hirano, Kenji Ichikawa, Mitsutoshi Kurosawa, Hiroaki Suzuki, Noriyuki Chiba, Takao Sugiyama, Yuko Minami, Hitoshi Niino, Atsushi Ihata, Ikuo Saito, Akiko Mitsuo, Toshitaka Maejima
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Hydroxychloroquine in Lupus Pregnancy and Risk of Preeclampsia Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-25 Amadeia Rector, Ivana Marić, Yashaar Chaichian, Eliza Chakravarty, Miranda Cantu, Michael H. Weisman, Gary M Shaw, Maurice L. Druzin, Julia F. Simard
Systemic lupus erythematosus (SLE) disproportionately affects women during childbearing years, and hydroxychloroquine (HCQ) is the standard first-line treatment. Preeclampsia complicates up to one-third of pregnancies in lupus patients, although reports vary by parity and multifetal gestation. We investigated whether taking HCQ early in pregnancy may reduce the risk of preeclampsia.
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Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate DNA Damage and Promote Osteoarthritis Development in Cartilage Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-25 Yongsik Cho, Hyeonkyeong Kim, Geunho Yook, Sangmin Yong, Soy Kim, Narae Lee, Yi-Jun Kim, Jin-Hee Kim, Tae Woo Kim, Moon Jong Chang, Kyoung Min Lee, Chong Bum Chang, Seung-Baik Kang, Jin-Hong Kim
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Plasma Matrix Metalloproteinase Concentrations and Risk of Interstitial Lung Disease in a Prospective Rheumatoid Arthritis Cohort Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-25 Brent A. Luedders, Austin M. Wheeler, Dana P. Ascherman, Joshua F. Baker, Michael J. Duryee, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Paul Monach, Andreas Reimold, Gail S. Kerr, Gary Kunkel, Grant W. Cannon, Jill A. Poole, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England
To evaluate the associations of plasma matrix metalloproteinases (MMPs) with prevalent and incident interstitial lung disease (ILD) in people with rheumatoid arthritis (RA).
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Clinical Characteristics of Cryopyrin-Associated Periodic Syndrome and Long-Term Real-World Efficacy and Tolerability of Canakinumab in Japan: Results of a Nationwide Survey Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-25 Takayuki Miyamoto, Kazushi Izawa, Sho Masui, Atsue Yamazaki, Yuichi Yamasaki, Tadashi Matsubayashi, Mayuka Shiraki, Hidenori Ohnishi, Junko Yasumura, Tomohiro Kawabe, Takako Miyamae, Tomoyo Matsubara, Naoya Arakawa, Takashi Ishige, Takumi Takizawa, Asami Shimbo, Masaki Shimizu, Naoki Kimura, Yuichi Maeda, Yuta Maruyama, Tomonari Shigemura, Junichi Furuta, Satoshi Sato, Hiroshi Tanaka, Miharu Izumikawa
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Myositis-Associated Autoantibodies in Patients With Juvenile Myositis Are Associated With Refractory Disease and Mortality Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-25 Matthew A. Sherman, Payam Noroozi Farhadi, Katherine Pak, Edward P. Trieu, Kakali Sarkar, Ira N. Targoff, Megan L. Neely, Andrew L. Mammen, Lisa G. Rider
Myositis-associated autoantibodies (MAAs) have been associated with overlap myositis, certain disease manifestations such as interstitial lung disease (ILD), and worse prognosis in the idiopathic inflammatory myopathies. MAAs overall remain largely uncharacterized in patients with juvenile-onset myositis. Moreover, it is unknown whether the number of MAAs is associated with disease severity.
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Vitamin D and Marine n-3 Fatty Acids for Autoimmune Disease Prevention: Outcomes Two Years After Completion of a Double-Blind, Placebo-Controlled Trial Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-25 Karen H. Costenbader, Nancy R. Cook, I-Min Lee, Jill Hahn, Joseph Walter, Vadim Bubes, Gregory Kotler, Nicole Yang, Sonia Friedman, Erik K. Alexander, JoAnn E. Manson
In the 5.3-year randomized, 2 × 2 factorial, double-blind, placebo-controlled Vitamin D and Omega-3 Trial (VITAL), vitamin D supplementation reduced autoimmune disease (AD) incidence (hazard ratio [HR] 0.78, 95% confidence interval [CI] 0.61–0.99). Omega-3 (n-3) fatty acid supplementation showed a statistically nonsignificant reduction (HR 0.85, 95% CI 0.67–1.08). We aimed to confirm further AD cases
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Modulation of Interleukin-23 Signaling With Guselkumab in Biologic-Naive Patients Versus Tumor Necrosis Factor Inhibitor–Inadequate Responders With Active Psoriatic Arthritis Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-22 Stefan Siebert, Laura C. Coates, Georg Schett, Siba P. Raychaudhuri, Warner Chen, Sheng Gao, Loqmane Seridi, Soumya D. Chakravarty, May Shawi, Frederic Lavie, Mohamed Sharaf, Miriam Zimmermann, Alexa P. Kollmeier, Xie L. Xu, Proton Rahman, Philip J. Mease, Atul Deodhar
We assessed and compared immunologic differences and associations with clinical response to guselkumab, a fully human interleukin (IL)–23p19 subunit inhibitor, in participants with active psoriatic arthritis (PsA) who were biologic-naive or had inadequate response to tumor necrosis factor inhibitors (TNFi-IR).
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Choosing to End African American Health Disparities in SLE Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-16 Matthew H. Liang, Edward R. Lew, Patricia A. Fraser, Cindy Flower, Edward H. Hennis, Sang-Cheol Bae, Anselm Hennis, Mohammed Tikly, W. Neal Roberts
Systemic Lupus erythematosus (SLE) is 3 times more common and its’ manifestations more severe in African American (AA) women compared to women of other races. It is not clear whether this is due to genetic differences or factors related to the physical or social environments, differences in health care or a combination of these factors. Health disparities in SLE between AAs and persons of other races
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Calprotectin Impairs Platelet Survival in Patients With Primary Antiphospholipid Syndrome Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-16 Claire K. Hoy, Somanathapura K. NaveenKumar, Sherwin A. Navaz, Kavya Sugur, Srilakshmi Yalavarthi, Cyrus Sarosh, Tristin Smith, Katarina Kmetova, Emily Chong, Noah F. Peters, Christine E. Rysenga, Gary L. Norman, Gabriel Figueroa-Parra, Dava Nelson, Jennifer Girard, Asra Z. Ahmed, Jordan K. Schaefer, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Jason S. Knight, Cynthia S. Crowson
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VEXAS-Defining UBA1 Somatic Variants in 245,368 Diverse Individuals in the NIH All Of Us Cohort Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-15 Robert W. Corty, James Brogan, Kevin Byram, Jason Springer, Peter C. Grayson, Alexander G. Bick
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Rheum at the Table for Everyone: A Call to Expand Rheumatology Knowledge for Primary Care Providers Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-14 Mary E. Margaretten, Jinoos Yazdany, Jennifer Mandal
Introduction In the past 25 years, there has been an explosion of rheumatology knowledge and treatment options simultaneously occurring with a decreased supply of rheumatologists to provide specialized care for patients with complex autoimmune diseases. Reasons for the workforce shortage include an aging population with increased prevalence of arthritis, more part-time clinicians, and increasing retirement
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Fractures in Patients With Acute Calcium Pyrophosphate Crystal Arthritis Versus Matched Comparators in a Large Cohort Study Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-14 Sara K. Tedeschi, Keigo Hayashi, Ann Rosenthal, Muneet Gill, Javier Marrugo, Sho Fukui, Ellen Gravallese, Daniel H. Solomon
Calcium pyrophosphate deposition (CPPD) disease was associated with osteopenia in two cross-sectional studies. We compared fracture risks in patients with acute calcium pyrophosphate (CPP) crystal arthritis versus matched comparators.
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Epigenetic Regulatory Axis MIR22-TET3-MTRNR2L2 Represses Fibroblast-Like Synoviocyte–Mediated Inflammation in Rheumatoid Arthritis Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-14 Yilong Fang, Wei Huang, Xiangling Zhu, Xinming Wang, Xuming Wu, Huihui Wang, Wenming Hong, Shangxue Yan, Lingling Zhang, Yujie Deng, Wei Wei, Jiajie Tu, Chen Zhu
The specific role of fibroblast-like synoviocytes (FLSs) in the pathogenesis of rheumatoid arthritis (RA) is still not fully elucidated. This study aimed to explore the molecular mechanisms of epigenetic pathways, including three epigenetic factors, microRNA (miRNA)-22 (MIR22), ten-eleven translocation methylcytosine dioxygenase 3 (TET3), and MT-RNR2 like 2 (MTRNR2L2), in RA-FLSs.
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Weight Loss for Patients With Gout and Concomitant Obesity: A Proof-of-Concept Randomized Trial Arthritis Rheumatol. (IF 13.3) Pub Date : 2024-01-02 Robin Christensen, Kristian Zobbe, Sabrina M. Nielsen, Lisa K. Stamp, Marius Henriksen, Anders F. Overgaard, Lene Dreyer, Filip K. Knop, Jasvinder A. Singh, Michael Doherty, Pascal Richette, Arne Astrup, Karen Ellegaard, Else M. Bartels, Mikael Boesen, Henrik Gudbergsen, Henning Bliddal, Lars Erik Kristensen
Despite scarce evidence, guidelines recommend weight loss as a management strategy for patients with gout. We investigated the effect of an intensive dietary intervention on body weight and clinical measures of gout severity in individuals with obesity and gout.
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Performance of DETECT PAH algorithm according to the hemodynamic definition of pulmonary arterial hypertension (PAH) in the 2022 ESC/ERS guidelines Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-25 Oliver Distler, Diana Bonderman, J Gerry Coghlan, Christopher P Denton, Ekkehard Grünig, Dinesh Khanna, Vallerie V McLaughlin, Ulf Müller-Ladner, Janet E Pope, Madelon C Vonk, Lilla Di Scala, Jean-Christophe Lemarie, Loïc Perchenet, Éric Hachulla
The evidence-based DETECT pulmonary arterial hypertension (PAH) algorithm is frequently used in systemic sclerosis (SSc) patients to help clinicians screen for PAH by using non-invasive data to recommend patient referral to echocardiography, and if applicable, for a diagnostic right heart catheterization (RHC). However, the hemodynamic definition of PAH was recently updated in the 2022 ESC/ERS guidelines
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Prognostic Role of Interferon-λ3 in Anti–Melanoma Differentiation–Associated Gene 5–Positive Dermatomyositis-Associated Interstitial Lung Disease Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-25 Atsuki Fukada, Tomoyuki Fujisawa, Hironao Hozumi, Keigo Koda, Taisuke Akamatsu, Yoshiyuki Oyama, Yasuomi Satake, Mitsuru Niwa, Yusuke Kaida, Hiroyuki Matsuda, Koshi Yokomura, Naoki Koshimizu, Mikio Toyoshima, Shiro Imokawa, Dai Hashimoto, Akira Yoshida, Takahisa Gono, Masataka Kuwana, Yasuhiko Yamano, Yasuhiro Kondoh, Keita Yamashita, Masato Maekawa, Kazutaka Mori, Yusuke Inoue, Hideki Yasui, Yuzo
Interferon-λ3 (IFNλ3) is a cytokine with antiviral functions on barrier surfaces, and it is associated with disease activity in autoimmune diseases. This study assessed the clinical significance of serum IFNλ3 levels in polymyositis/dermatomyositis (PM/DM)–associated interstitial lung disease (ILD).
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The incidence of uveitis in patients with axial spondylarthritis treated with biologics or targeted synthetics: a systematic review and network meta-analysis Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-20 Katie Bechman, Zijing Yang, Maryam Adas, Deepak Nagra, Ali Soykan Uguzlar, Mark D Russell, Nicky Wilson, Sophia Steer, Sam Norton, James Galloway
Uveitis is a common extra-articular manifestation of axial spondylarthritis (AxSpA). We set to evaluate risk of anterior uveitis (AU) with biologics and synthetic disease-modifying drugs in AxSpA.
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CD19 CAR-T cell treatment: Unraveling the role of B cells in Systemic Lupus Erythematosus Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-19 Jule Taubmann, Fabian Müller, Melek Yalcin Mutlu, Simon Völkl, Michael Aigner, Aline Bozec, Andreas Mackensen, Ricardo Grieshaber-Bouyer, Georg Schett
B cell generation of autoantibodies is a crucial step in the pathogenesis of systemic lupus erythematosus (SLE). After their differentiation in the bone marrow, B cells populate the secondary lymphatic organs, where they undergo further maturation leading to the development of memory B cells as well as antibody-producing plasmablasts and plasma cells. Targeting B cells is an important strategy to treat
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Association of Combined Anti-Ro52/TRIM21 and Anti-Ro60/SSA Antibodies With Increased Sjögren Disease Severity Through Interferon Pathway Activation Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-21 Eléonore Bettacchioli, Alain Saraux, Alice Tison, Divi Cornec, Maryvonne Dueymes, Nathan Foulquier, Sophie Hillion, Anne-Marie Roguedas-Contios, Anas-Alexis Benyoussef, Marta E. Alarcon-Riquelme, Jacques-Olivier Pers, Valérie Devauchelle-Pensec
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Screening of Environmental Chemicals to Characterize Exposures in Participants With Systemic Lupus Erythematosus Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-21 Cristina M. Lanata, Kimberly E. Taylor, James Hurst-Hopf, Joanne Nititham, Ashira Blazer, Laura Trupin, Patricia Katz, Maria Dall'Era, Jinoos Yazdany, Sharon A. Chung, Dimitri Abrahamsson, Roy Gerona, Lindsey A. Criswell
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Clinical Images: Crowned dens syndrome detected on 18F-fludeoxyglucose–positron emission tomography/computed tomography during investigation for giant cell arteritis Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-18 Miao Yunn Lim, Ivan Ho Shon, Anthony M. Sammel
The patient, a 66-year-old woman, presented to the emergency department with severe occipital and temporal headache, shoulder and neck pain with restricted range of movement, and nonspecific binocular vision disturbance. Initial investigations revealed an elevated C-reactive protein level of 52 mg/L (reference <3 mg/L) and an erythrocyte sedimentation rate of 20 mm/hr (reference range 0–20 mm/hr).
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Declining Incidence of Systemic Lupus Erythematosus in Norway 1999–2017: Data From a Population Cohort Identified by International Classification of Diseases, 10th Revision Code and Verified by Classification Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-18 Hilde Haukeland, Sigrid R. Moe, Cathrine Brunborg, Antonela Botea, Nenad Damjanic, Gro Å. Wivestad, Heidi K. Øvreås, Thea B. Bøe, Anniken Orre, Torhild Garen, Øyvind Molberg, Karoline Lerang
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Difficult-to-Treat Psoriatic Arthritis: A Conceptual Approach Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-18 Filippo Fagni, Francesca Motta, Georg Schett, Carlo Selmi
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Histone-Specific CD4+ T Cell Plasticity in Active and Quiescent Systemic Lupus Erythematosus Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-18 Giuseppe A. Ramirez, Elena Tassi, Maddalena Noviello, Benedetta A. Mazzi, Luca Moroni, Lorena Citterio, Laura Zagato, Enrico Tombetti, Matteo Doglio, Elena M. Baldissera, Enrica P. Bozzolo, Chiara Bonini, Lorenzo Dagna, Angelo A. Manfredi
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Antiinflammatory Effect of High-Density Lipoprotein Blunted by Delivery of Altered MicroRNA Cargo in Patients With Rheumatoid Arthritis Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-18 Qiong Wu, Quanhu Sheng, Danielle Michell, Marisol Ramirez-Solano, Olivia Posey, Anastasiia Phothisane, Shahensha Shaik, Kasey C. Vickers, Michelle J. Ormseth
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Effect of Anti-S100A4 Monoclonal Antibody Treatment on Experimental Skin Fibrosis and Systemic Sclerosis–Specific Transcriptional Signatures in Human Skin Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-18 Thuong Trinh-Minh, Andrea-Hermina Györfi, Michal Tomcik, Cuong Tran-Manh, Xiang Zhou, Nicholas Dickel, Bilgesu Safak Tümerdem, Alexander Kreuter, Sven-Niklas Burmann, Signe Vedel Borchert, Rizwan Iqbal Hussain, Jonas Hallén, Jörg Klingelhöfer, Meik Kunz, Jörg H. W. Distler
S100A4 is a DAMP protein. S100A4 is overexpressed in patients with systemic sclerosis (SSc), and levels correlate with organ involvement and disease activity. S100A4−/− mice are protected from fibrosis. The aim of this study was to assess the antifibrotic effects of anti-S100A4 monoclonal antibody (mAb) in murine models of SSc and in precision cut skin slices of patients with SSc.
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A Mobile Health Application Integrated in the Electronic Health Record for Rheumatoid Arthritis Patient-Reported Outcomes: A Controlled Interrupted Time-Series Analysis of Impact on Visit Efficiency Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-12 Daniel H. Solomon, Hallie Altwies, Leah Santacroce, Jack Ellrodt, Tammy Pham, Jacklyn Stratton, Adam Landman, Anuj Dalal, Jamie Collins, Robert S. Rudin
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Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS) Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-10 Elena Pontarini, Elisabetta Sciacca, Farzana Chowdhury, Sofia Grigoriadou, Felice Rivellese, William J. Murray-Brown, Davide Lucchesi, Liliante Fossati-Jimack, Alessandra Nerviani, Edyta Jaworska, Giulia Maria Ghirardi, Chiara Giacomassi, Paul Emery, Wan Fai Ng, Nurhan Sutcliffe, Colin Everett, Catherine Fernandez, Anwar Tappuni, Raphael Seror, Xavier Mariette, Raphael Porcher, Giulia Cavallaro, Alfredo
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Local Ancestry at the Major Histocompatibility Complex Region is Not a Major Contributor to Disease Heterogeneity in a Multiethnic Lupus Cohort Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-10 Olivia Solomon, Cristina M. Lanata, Cameron Adams, Joanne Nititham, Kimberly E. Taylor, Sharon A. Chung, Jinoos Yazdany, Maria Dall'Era, Bernado A. Pons-Estel, Teresa Tusié-Luna, Betty Tsao, Eric Morand, Marta E. Alarcón-Riquelme, Lisa F. Barcellos, Lindsey A. Criswell
Systemic lupus erythematosus (SLE) is an autoimmune disease resulting in debilitating clinical manifestations that vary in severity by race and ethnicity with a disproportionate burden in African American, Mestizo, and Asian populations compared with populations of European descent. Differences in global and local genetic ancestry may shed light on the underlying mechanisms contributing to these disparities
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Different Immunologic Profiles Are Associated With Distinct Clinical Phenotypes in Longitudinally Observed Patients With Systemic Lupus Erythematosus Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-10 Kieran Manion, Carolina Muñoz-Grajales, Michael Kim, Eshetu Atenafu, Zoha Faheem, Dafna D. Gladman, Murray Urowitz, Zahi Touma, Joan E. Wither
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Weight Loss Induced by Antiobesity Medications and All-Cause Mortality Among Patients With Knee or Hip Osteoarthritis Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-06 Jie Wei, David Hunter, Nancy E. Lane, Jing Wu, Chao Zeng, Guanghua Lei, Yuqing Zhang
The current guidelines recommend weight loss for patients with overweight or obesity and knee or hip osteoarthritis (OA); however, there is a paucity of data on the relation of weight loss to death among patients with OA. We aimed to examine the relation of the rate of weight loss induced by antiobesity medications over one year to all-cause mortality among patients with overweight or obesity and knee
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Clinical Features and Immunogenetic Risk Factors Associated With Additional Autoantibodies in Anti-Transcriptional Intermediary Factor 1γ Juvenile-Onset Dermatomyositis Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-07 Matthew A. Sherman, Qingyuan Yang, Laura Gutierrez-Alamillo, Katherine Pak, Willy A. Flegel, Andrew L. Mammen, Lisa G. Rider, Livia A. Casciola-Rosen
Novel autoantibody specificities including anti-CCAR1 were recently discovered in adult patients with anti-transcriptional intermediary factor (TIF1)–positive dermatomyositis (DM) and were associated with attenuated cancer emergence. The aims of the present study were to examine whether these autoantibodies occur in patients with juvenile-onset DM (JDM) and to determine their associated features.
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Poly-Refractory Rheumatoid Arthritis: An Uncommon Subset of Difficult to Treat Disease With Distinct Inflammatory and Noninflammatory Phenotypes Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-12-07 Paula David, Andrea Di Matteo, Or Hen, Shouvik Dass, Helena Marzo-Ortega, Richard J. Wakefield, Leslie-Anne Bissell, Jacqueline Nam, Kulveer Mankia, Paul Emery, Benazir Saleem, Dennis McGonagle
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Using Polygenic Risk Scores to Aid Diagnosis of Patients With Early Inflammatory Arthritis: Results From the Norfolk Arthritis Register Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-11-27 Ryan M. Hum, Seema D. Sharma, Michael Stadler, Sebastien Viatte, Pauline Ho, Nisha Nair, Chenfu Shi, Chuan Fu Yap, Mehreen Soomro, Darren Plant, Jenny H. Humphreys, Alexander MacGregor, Max Yates, Suzanne Verstappen, Anne Barton, John Bowes
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Programmed Death Ligand 1–Expressing Macrophages and Their Protective Role in the Joint During Arthritis Arthritis Rheumatol. (IF 13.3) Pub Date : 2023-11-24 Megan Kay Wood, Abdel Daoud, Monica Vladut Talor, Hannah Maryam Kalinoski, David Matthew Hughes, Camille Marie Jaime, Jody Elizabeth Hooper, Taejoon Won, Daniela Čiháková
Arthritis associated with immune checkpoint inhibitor therapies highlights the importance of immune checkpoint expression for joint homeostasis. We investigated the role of programmed death ligand (PD-L) 1 in the synovium using a collagen-induced arthritis (CIA) mouse model.