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Advances in the treatment of hepatocellular carcinoma: An overview of the current and evolving therapeutic landscape for clinicians CA: Cancer J. Clin. (IF 503.1) Pub Date : 2025-05-20 Dimitrios Moris, Alessandro Martinino, Sarah Schiltz, Peter J. Allen, Andrew Barbas, Debra Sudan, Lindsay King, Carl Berg, Charles Kim, Mustafa Bashir, Manisha Palta, Michael A. Morse, Michael E. Lidsky
Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third leading cause of cancer-related death worldwide. Contemporary advances in systemic and locoregional therapies have led to changes in peer-reviewed guidelines regarding systemic therapy as well as the possibility of downstaging disease that may enable some patients with advanced disease to ultimately undergo partial hepatectomy
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Starvation as a weapon of war in Gaza: violation of international law Lancet (IF 98.4) Pub Date : 2025-05-20 Yara Ashour, Abdallah Abu-Jlambo, Samer Abuzerr
No Abstract
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A new definition of human health is needed to better implement One Health Lancet (IF 98.4) Pub Date : 2025-05-19 Thierry Lefrançois, Jean-Luc Angot, Brigitte Autran, Salome A Bukachi, Elisabeth Claverie de Saint-Martin, Patrick Giraudoux, Estelle Lefrançois, Bruno Lina, Khuat Thi Hai Oanh, David O Obura, Jean-François Delfraissy
No Abstract
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A pillar of Brazilian public health: Fiocruz at 125 Lancet (IF 98.4) Pub Date : 2025-05-19 Lise Alves
No Abstract
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Nutrition research must go local Nat. Med. (IF 58.7) Pub Date : 2025-05-20
Understanding the health impacts of local, culturally relevant diets will be critical to advancing precision nutrition across diverse populations in a sustainable way.
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Cancer treatment paradigms in the precision medicine era Nat. Med. (IF 58.7) Pub Date : 2025-05-20 Vivek Subbiah, Giuseppe Curigliano, Jason K. Sicklick, Shumei Kato, Kjetil Tasken, Arielle Medford, Damian T. Rieke, Hui-Zi Chen, Adam Wahida, Lars Buschhorn, Denis Horgan, Razelle Kurzrock
To fully harness precision medicine and transform cancer care for the better will require a strategic shift to highly personalized interventions that embrace innovation and adaptability.
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Author Correction: Prediction of mental health risk in adolescents Nat. Med. (IF 58.7) Pub Date : 2025-05-19 Elliot D. Hill, Pratik Kashyap, Elizabeth Raffanello, Yun Wang, Terrie E. Moffitt, Avshalom Caspi, Matthew Engelhard, Jonathan Posner
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03560-7, published online 5 March 2025.
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Addendum: Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase Nat. Med. (IF 58.7) Pub Date : 2025-05-19 Elmer B Santos, Raymond Yeh, James Lee, Yan Nikhamin, Blesida Punzalan, Blesserene Punzalan, Krista La Perle, Steven M Larson, Michel Sadelain, Renier J Brentjens
Addendum to: Nature Medicine https://doi.org/10.1038/nm.1930, published online 15 February 2009.
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Core GRADE 5: rating certainty of evidence—assessing indirectness BMJ (IF 93.6) Pub Date : 2025-05-20 Gordon Guyatt, Alfonso Iorio, Hans De Beer, Andrew Owen, Thomas Agoritsas, M Hassan Murad, Ganesan Karthikeyan, Carlos Cuello, Manya Prasad, Kevin Kim, Dalal S Ali, Arnav Agarwal, Lars G Hemkens, Liang Yao, Monica Hultcrantz, Jamie Rylance, Derek K Chu, Per Olav Vandvik, Benjamin Djulbegovic, Reem A Mustafa, Linan Zeng, Prashanti Eachempati, Bram Rochwerg, Kameshwar Prasad, Victor M Montori, Romina
This fifth article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach to systematic reviews, clinical practice guidelines, and health technology assessments and addresses issues of indirect evidence. Guideline developers and health technology assessment practitioners must carefully specify the population, intervention, comparison
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Incidence and prevalence of dementia among US Medicare beneficiaries, 2015-21: population based study BMJ (IF 93.6) Pub Date : 2025-05-20 Beau Blass, Cassie B Ford, Samir Soneji, Lindsay Zepel, Talita D’Aguiar Rosa, Brystana G Kaufman, Sneha Mantri, Fan Li, Brian Mac Grory, Ying Xian, Kim G Johnson, Richard O’Brien, Bradley G Hammill, Emily C O’Brien, Jay B Lusk
Objective To determine the incidence and prevalence of dementia in a nationally representative cohort of US Medicare beneficiaries, stratified by important subgroups. Design Population based study. Setting Nationwide study between 2015 and 2021. Participants Fee-for-service Medicare beneficiaries aged 66 or older with at least one year of continuous enrollment. Main outcome measures Incidence and prevalence
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Managing multimorbidity can help people with dementia live better for longer BMJ (IF 93.6) Pub Date : 2025-05-20 Jay B Lusk
As people live longer with dementia, we must balance the benefits and harms of medical interventions to meet unique individual needs, writes Jay B Lusk Much attention has been paid to the development of new drug treatments for Alzheimer’s disease. Interventions to target the pathophysiology of the most common form of dementia are essential to tackle its rising public health burden. Amid intense debates
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Paula Salmons: psychiatrist who established eating disorder service in Birmingham and warned against social pressure on women and girls to be thin BMJ (IF 93.6) Pub Date : 2025-05-20 Debby Elley
In the early 1980s a well dressed woman in high heels entered a police station in Birmingham. She had come to see a police officer who had become violent and had had to be restrained by colleagues. He was now locked in one of his own cells. On her arrival she was asked, “Where’s the psychiatrist?” Paula Salmons responded, “I am the psychiatrist.” Women were then in the minority in psychiatry and Salmons
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Rethinking clinical trial design and electronic health record systems could improve clinical research in the UK BMJ (IF 93.6) Pub Date : 2025-05-20 Helena Marzo-Ortega
Husain describes the need for closer collaboration between universities and NHS organisations.1 At the heart of this struggling relationship are financial pressures, with partnered institutions essentially competing for clinical trials as a potential source of income. Clinical trials research is key to improving patient care and belongs in the NHS,2 while universities drive innovation and knowledge
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Gonorrhoea: rising cases and antimicrobial resistance BMJ (IF 93.6) Pub Date : 2025-05-20 Peter Davis, Eloise Williams, Monique I Andersson, Odile B Harrison, Susanne H Hodgson
Novel interventions are needed to tackle a public health crisis Annually, there are more than 82 million cases of gonorrhoea worldwide.1 In 2023, England recorded more than 85 000 gonorrhoea diagnoses—the highest annual incidence since records began in 1918 and a threefold increase since 2012.2 This dramatic rise in case numbers is not limited to the UK: in Europe notification rates increased by more
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Descriptive epidemiology of dementia in the US BMJ (IF 93.6) Pub Date : 2025-05-20 Sara Ahmadi-Abhari, Carol Brayne
Using routine data to uncover underlying trends presents challenges Population estimates of dementia have, in recent decades, become of national interest to policy makers, politicians and the wider community. In a linked study (doi:10.1136/bmj-2024-083034), Blass and colleagues report estimates of the incidence and prevalence of dementia in the US Medicare fee-for-service health insurance system for
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Setting priorities for climate and health adaptation BMJ (IF 93.6) Pub Date : 2025-05-20 Siddhanth Sharma, Anand Bhopal, Angela Y Chang
Siddhanth Sharma and colleagues argue that adaptation to cope with the health effects of climate change requires more focused local data and dedicated funding Climate change is often called “the greatest 21st century health threat.”1 Substantial and growing evidence shows its harmful effects on health through various pathways, including heat stress, drought, and shifting infectious disease patterns
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Diagnosis and management of gonorrhoea BMJ (IF 93.6) Pub Date : 2025-05-19 Sophie Ross, Nicolas Pinto-Sander, Collins Iwuji
### What you need to know Gonorrhoea is of increasing concern for global sexual health. Continued stigmatisation of sexual health, particularly for those in marginalised communities, contributes to increasing incidence, greater complexity of cases, and the rise of multidrug resistant strains.1 Antimicrobial resistance (AMR) limits treatment options. Condoms are highly effective at preventing transmission
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Mary Lindsay: paediatrician and psychiatrist who championed the right of parents to stay with their children in hospital BMJ (IF 93.6) Pub Date : 2025-05-19 Rebecca Wallersteiner
“If you take a sick child from its parents or nurse you break its heart immediately,” wrote physician George Armstrong in 1792. Mary Lindsay took these words to heart and throughout her seven decades as a paediatrician she campaigned for children staying in hospital to be accompanied by their parents. When she began practising in the early 1950s, visiting hours were severely restricted, based on misconceptions
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Smartphones and children: teenage mental health is suffering BMJ (IF 93.6) Pub Date : 2025-05-19 Giles W Dawnay
Goodyear and colleagues argue that smartphone and social media regulation must go beyond bans.1 As a GP, I have noticed that mental health consultations with teenagers are on the rise. Depression, lack of meaning, and body dissatisfaction are the main topics of discussion. Female teenagers’ mental health has plummeted, with hospital admissions for self-harm and suicidality rising 112.8% between 2012-23
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Obesity: can we cure our dependence on BMI? BMJ (IF 93.6) Pub Date : 2025-05-19 Carla Delgado
Obesity remains defined by the flawed metric at the heart of its diagnosis—BMI. Carla Delgado reports on the fresh attempts to move away from this, as weight loss drugs usher in a new age for the obesity crisis The explosion in popularity of weight loss drugs such as semaglutide (Wegovy, Ozempic) and tirzepatide (Zepbound, Mounjaro) has brought a twist to the management of obesity. Patients usually
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Care home funding: lessons from Scotland BMJ (IF 93.6) Pub Date : 2025-05-19 Catherine Russell, Nick Kempe, Cam Donaldson
Scrap means testing for personal care and regulate care home charges The care home market in the UK is characterised by rising fees, inadequate capacity, and deteriorating care standards.12345 As governments in England and Scotland review how care is funded, lessons can be learnt from the Scottish model, which since 2002 has offered free personal and nursing care to people over 65. The Scottish parliament’s
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Building a sustainable model for global maternal health BMJ (IF 93.6) Pub Date : 2025-05-19 Özge Tunçalp, Joshua P Vogel, Seni Kouanda, Tippawan Liabsuetrakul
World Health Assembly in 2025 presents a renewed opportunity The World Health Organization’s latest estimates on trends and causes of maternal mortality are sobering.12 Despite decades of socioeconomic progress and accumulated knowledge on how to prevent maternal deaths, the global burden is stubbornly high—and in some areas, it is worsening. Maternal mortality in sub-Saharan Africa remains disproportionately
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Heterogeneous effects of Medicaid coverage on cardiovascular risk factors: secondary analysis of randomized controlled trial BMJ (IF 93.6) Pub Date : 2025-05-19 British Medical Journal Publishing Group
After publication, by Inoue and colleagues ( BMJ 2024;386:e079377, doi:10.1136/bmj-2024-079377), the authors spotted a coding error. Specifically, the original code did not appropriately use the out-of-bag prediction in the …
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Effects of Medicaid coverage on cardiovascular health outcomes BMJ (IF 93.6) Pub Date : 2025-05-19 British Medical Journal Publishing Group
This editorial ( BMJ 2024;386:q1807, doi:10.1136/bmj.q1807) has …
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The consultant anaesthetist who established a support group for autistic doctors BMJ (IF 93.6) Pub Date : 2025-05-19 Kathy Oxtoby
Consultant anaesthetist Mary Doherty talks to Kathy Oxtoby about being autistic and being a doctor *Print headline* Role model: Mary Doherty When Mary Doherty was diagnosed as autistic in 2013, in her mid-40s, “looking back it explained so much of my life.” “But the question then was, ‘Can you be autistic and be a doctor?’” says Doherty, a clinical associate professor at University College Dublin School
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Nerandomilast in Patients with Progressive Pulmonary Fibrosis. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-05-19 Toby M Maher,Shervin Assassi,Arata Azuma,Vincent Cottin,Anna-Maria Hoffmann-Vold,Michael Kreuter,Justin M Oldham,Luca Richeldi,Claudia Valenzuela,Marlies S Wijsenbeek,Emmanuelle Clerisme-Beaty,Carl Coeck,Hui Gu,Ivana Ritter,Arno Schlosser,Susanne Stowasser,Florian Voss,Gerrit Weimann,Donald F Zoz,Fernando J Martinez,
BACKGROUND Nerandomilast (BI 1015550) is an orally administered preferential inhibitor of phosphodiesterase 4B with antifibrotic and immunomodulatory properties. Nerandomilast has been shown to slow the progression of idiopathic pulmonary fibrosis, but an assessment of its effects in other types of progressive pulmonary fibrosis is needed. METHODS In a phase 3, double-blind trial, we randomly assigned
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Progress through Persistence - Turning the Page in Pulmonary Fibrosis Clinical Trials. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-05-19 Joyce S Lee
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Why are UK cardiovascular deaths in under 65s rising again? BMJ (IF 93.6) Pub Date : 2025-05-19 Sophie Borland
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Personalised CRISPR therapy: Could it transform treatment of genetic disease? BMJ (IF 93.6) Pub Date : 2025-05-19 Jacqui Wise
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Trump nominates unconventional doctor as new surgeon general. BMJ (IF 93.6) Pub Date : 2025-05-19 Janice Hopkins Tanne
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The Search for the Single Best Sedative. JAMA (IF 63.1) Pub Date : 2025-05-19 Edward T Qian,Todd W Rice
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Transcriptomic Profiles in Nasal Epithelium in Youth With Asthma-Reply. JAMA (IF 63.1) Pub Date : 2025-05-19 Molin Yue,Kristina Gaietto,Juan C Celedón
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Long-Acting HIV Treatment in Low- and Middle-Income Countries JAMA (IF 63.1) Pub Date : 2025-05-19 Peter D. Ehrenkranz, Michael J. A. Reid, Meg Doherty, Peter S. Kim
This Viewpoint discusses the need to develop products, such as long-acting antiretrovirals, for people with HIV in settings with minimal resource requirements.
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Immune Thrombotic Thrombocytopenic Purpura JAMA (IF 63.1) Pub Date : 2025-05-19 Allyson M. Pishko, Ang Li, Adam Cuker
ImportanceImmune thrombotic thrombocytopenic purpura (iTTP) is a life-threatening thrombotic microangiopathy that presents with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. Worldwide annual incidence of iTTP is 2 cases per million to 6 cases per million.ObservationsImmune TTP is caused by an autoantibody to a disintegrin and metallopeptidase with thrombospondin type 1 motif 13 (ADAMTS13)
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Nerandomilast in Patients with Idiopathic Pulmonary Fibrosis. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-05-18 Luca Richeldi,Arata Azuma,Vincent Cottin,Michael Kreuter,Toby M Maher,Fernando J Martinez,Justin M Oldham,Claudia Valenzuela,Emmanuelle Clerisme-Beaty,Maud Gordat,Daniel Wachtlin,Yi Liu,Christina Schlecker,Susanne Stowasser,Donald F Zoz,Marlies S Wijsenbeek,
BACKGROUND Nerandomilast (BI 1015550) is an orally administered preferential inhibitor of phosphodiesterase 4B with antifibrotic and immunomodulatory effects. In a phase 2 trial involving patients with idiopathic pulmonary fibrosis, treatment with nerandomilast stabilized lung function over a period of 12 weeks. METHODS In this phase 3, double-blind trial, we randomly assigned patients with idiopathic
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Navigational Bronchoscopy or Transthoracic Needle Biopsy for Lung Nodules. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-05-18 Robert J Lentz,Katherine Frederick-Dyer,Virginia B Planz,Tatsuki Koyama,Matthew C Aboudara,Sameer K Avasarala,Jonathan D Casey,George Z Cheng,Pierre-François D'Haese,Jennifer D Duke,Eric L Grogan,Todd C Hoopman,Joyce Johnson,James M Katsis,Jonathan S Kurman,See-Wei Low,Kamran Mahmood,Otis B Rickman,Lance Roller,Cristina Salmon,Samira Shojaee,Briana Swanner,Momen M Wahidi,Charla Walston,Gerard A Silvestri
BACKGROUND Each year, millions of pulmonary nodules are identified incidentally or through lung cancer screening, and many involve biopsy to distinguish cancer from benign processes. Both navigational bronchoscopy and computed tomography-guided transthoracic needle biopsy are commonly used in patients undergoing biopsies of peripheral pulmonary nodules, but the relative diagnostic accuracy of these
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Methotrexate as Initial Therapy for Symptomatic Pulmonary Sarcoidosis? N. Engl. J. Med. (IF 96.2) Pub Date : 2025-05-18 Robert P Baughman,Elyse E Lower
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First-Line Treatment of Pulmonary Sarcoidosis with Prednisone or Methotrexate. N. Engl. J. Med. (IF 96.2) Pub Date : 2025-05-18 Vivienne Kahlmann,Montse Janssen Bonás,Catharina C Moor,Jan C Grutters,Rémy L M Mostard,Henricus N A J van Rijswijk,Jan van der Maten,Emiel R Marges,Linda A A Moonen,Maria J Overbeek,Bart Koopman,Daan W Loth,Esther J Nossent,Michiel Wagenaar,Henk Kramer,Pascal L M L Wielders,Peter I Bonta,Stefan Walen,Brigitte A H A Bogaarts,Réne Kerstens,Mayka Overgaauw,Marcel Veltkamp,Marlies S Wijsenbeek
BACKGROUND Prednisone is currently recommended as the first-line treatment for pulmonary sarcoidosis but is associated with many side effects. Methotrexate, which is recommended as a second-line treatment, appears to have fewer side effects than prednisone but a slower onset of action. Data are needed on the efficacy and side-effect profile of methotrexate as compared with prednisone as first-line
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Biopsy of Peripheral Lung Nodules - Inside Out or Outside In? N. Engl. J. Med. (IF 96.2) Pub Date : 2025-05-18 Michael K Gould
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A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease. JAMA (IF 63.1) Pub Date : 2025-05-18 ,Surya P Bhatt,Ehsan Abadi,Antonio Anzueto,Sandeep Bodduluri,Richard Casaburi,Peter J Castaldi,Michael H Cho,Alejandro P Comellas,Douglas J Conrad,Jeffrey L Curtis,Chandra Dass,Dawn L DeMeo,Mark T Dransfield,Raul San José Estépar,Eric L Flenaugh,Marilyn G Foreman,Spyridon Fortis,Arnav Gupta,MeiLan K Han,Nicola A Hanania,Craig P Hersh,John E Hokanson,Stephen M Humphries,Miranda Kirby,Ken M Kunisaki
Importance Individuals at risk for chronic obstructive pulmonary disease (COPD) but without spirometric airflow obstruction can have respiratory symptoms and structural lung disease on chest computed tomography. Current guidelines recommend COPD diagnostic schemas that do not incorporate imaging abnormalities. Objective To determine whether a multidimensional COPD diagnostic schema that includes respiratory
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Beyond Obstruction-A Milestone in COPD Diagnosis. JAMA (IF 63.1) Pub Date : 2025-05-18 Francesca Polverino
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Dietary energy in balance: time for an update of energy requirements Lancet (IF 98.4) Pub Date : 2025-05-16 L M Neufeld, C U Loechl
No Abstract
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The potential impact of the Trump administration policies on health research in the USA Lancet (IF 98.4) Pub Date : 2025-05-16 Steven H Woolf, Sandro Galea, David R Williams
No Abstract
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Ending nuclear weapons, before they end us Lancet (IF 98.4) Pub Date : 2025-05-16 Kamran Abbasi, Parveen Ali, Virginia Barbour, Marion Birch, Inga Blum, Peter Doherty, Andy Haines, Ira Helfand, Richard Horton, Kati Juva, Jose F Lapena, Robert Mash, Olga Mironova, Arun Mitra, Carlos Monteiro, Elena N Naumova, David Onazi, Tilman Ruff, Peush Sahni, James Tumwine, Chris Zielinski
No Abstract
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Using metformin to stall clonal hematopoiesis Nat. Med. (IF 58.7) Pub Date : 2025-05-16
Three translational studies reveal elevated mitochondrial metabolism as a driver of age-related clonal hematopoiesis and suggest that targeting this process — for example, with metformin — could reduce the risk of associated diseases.
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Comprehensive management of vulvovaginal cancers CA: Cancer J. Clin. (IF 503.1) Pub Date : 2025-05-16 Angélica Nogueira-Rodrigues, Maaike H. M. Oonk, Domenica Lorusso, Brian Slomovitz, Mario M. Leitão, Glauco Baiocchi
Vulvar and vaginal cancers represent rare malignancies, with an incidence of 2.7 per 100,000 women for vulvar cancer, predominantly affecting women older than 60 years, although rising rates are observed in younger demographics. Approximately 90% of vulvar cancers are squamous cell carcinoma and frequently are associated with human papillomavirus (HPV) infection. Vaginal cancer, constituting less than
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Clozapine: old drugs require efforts to improve patient experience and access Lancet (IF 98.4) Pub Date : 2025-05-15 Jack B Fanshawe, Thomas Kabir, Belinda R Lennox
No Abstract
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Safety and efficacy of a novel ANGPTL4 inhibitory antibody for lipid lowering: results from phase 1 and phase 1b/2a clinical studies Lancet (IF 98.4) Pub Date : 2025-05-15 Beryl B Cummings, Mark P Joing, Page R Bouchard, Mark N Milton, Peter F Moesta, Vyas Ramanan, Andrew Lane, Joe Hirman, John W Trauger, Eleftheria Maratos-Flier, Andrei Voznesensky, Igor Splawski, Amitabh V Nimonkar, Meghan M Flaherty, B Alexander Yi, Daniel Meyers, Francois Huet, Sukhdeep K Sahambi, Denise P Yates, Douglas Hom, Ethan J Weiss
BackgroundGenetic studies have established angiopoietin-related protein 4 (ANGPTL4) as a key regulator of triglyceride metabolism and a promising target to reduce atherosclerotic cardiovascular disease (ASCVD) risk beyond traditional risk factors. Human ANGPTL4 loss-of-function shows no adverse consequences and is associated with reduced triglycerides and remnant cholesterol, and a reduced risk of
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Safely lowering triglycerides through ANGPTL4 inhibition Lancet (IF 98.4) Pub Date : 2025-05-15 Anders B Wulff
No Abstract
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Trump vs higher education: stifling American innovation Lancet (IF 98.4) Pub Date : 2025-05-15
No Abstract
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Traditional Chinese medicine for acute intracerebral haemorrhage Lancet (IF 98.4) Pub Date : 2025-05-15 Renqi Luo, Hui Hui, Haodong Ge, Xue Ran
No Abstract
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Traditional Chinese medicine for acute intracerebral haemorrhage Lancet (IF 98.4) Pub Date : 2025-05-15 Arthur Yin Fan, Sherman Gu, Changzhen Gong
No Abstract
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Traditional Chinese medicine for acute intracerebral haemorrhage Lancet (IF 98.4) Pub Date : 2025-05-15 Hongbo Jia, Wei Liu, Xiaonong Fan, Yibing Li, Li Li
No Abstract
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Traditional Chinese medicine for acute intracerebral haemorrhage Lancet (IF 98.4) Pub Date : 2025-05-15 Fengjun Zhang, Zhe Wang, Wencheng Kong, Wei Zhang, Tao Wang
No Abstract
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Traditional Chinese medicine for acute intracerebral haemorrhage Lancet (IF 98.4) Pub Date : 2025-05-15 Yanchen Zhu, Jiqiang Hu, Shaozhen Ji, Mingkai Huang
No Abstract
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Traditional Chinese medicine for acute intracerebral haemorrhage Lancet (IF 98.4) Pub Date : 2025-05-15 Xiaolong Xu, Huahao Fan, Qingquan Liu
No Abstract