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  • Issue Information ‐ Cover
    CA: Cancer J. Clin. (IF 223.679) Pub Date : 2020-04-06
    更新日期:2020-04-06
  • A review of cancer immunotherapy toxicity.
    CA: Cancer J. Clin. (IF 223.679) Pub Date : 2020-01-16
    Lucy Boyce Kennedy,April K S Salama

    Cancer immunotherapies, including checkpoint inhibitors and adoptive cell therapy, manipulate the immune system to recognize and attack cancer cells. These therapies have the potential to induce durable responses in multiple solid and hematologic malignancies and thus have transformed treatment algorithms for numerous tumor types. Cancer immunotherapies lead to unique toxicity profiles distinct from

    更新日期:2020-04-06
  • Enhancing global access to cancer medicines.
    CA: Cancer J. Clin. (IF 223.679) Pub Date : 2020-02-18
    Javier Cortes,Jose Manuel Perez-García,Antonio Llombart-Cussac,Giuseppe Curigliano,Nagi S El Saghir,Fatima Cardoso,Carlos H Barrios,Shama Wagle,Javier Roman,Nadia Harbeck,Alexandru Eniu,Peter A Kaufman,Josep Tabernero,Laura García-Estévez,Peter Schmid,Joaquín Arribas

    Globally, cancer is the second leading cause of death, with numbers greatly exceeding those for human immunodeficiency virus/acquired immunodeficiency syndrome, tuberculosis, and malaria combined. Limited access to timely diagnosis, to affordable, effective treatment, and to high-quality care are just some of the factors that lead to disparities in cancer survival between countries and within countries

    更新日期:2020-04-06
  • An overview of precision oncology basket and umbrella trials for clinicians.
    CA: Cancer J. Clin. (IF 223.679) Pub Date : 2020-02-07
    Jay J H Park,Grace Hsu,Ellie G Siden,Kristian Thorlund,Edward J Mills

    With advancements in biomarkers and momentum in precision medicine, biomarker-guided trials such as basket trials and umbrella trials have been developed under the master protocol framework. A master protocol refers to a single, overarching design developed to evaluate multiple hypotheses with the general goal of improving the efficiency of trial evaluation. One type of master protocol is the basket

    更新日期:2020-04-06
  • Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response
    JAMA (IF 51.273) Pub Date : 2020-04-06
    Deborah J. Cook; John C. Marshall; Robert A. Fowler

    Dedicated, impassioned, and exhausted clinicians the world over are collaborating to report the emerging profile of the coronavirus disease 2019 (COVID-19) pandemic. The unparalleled need for intensive care during this period challenges clinicians to bring their best efforts to the bedside, while advising health care leaders on the optimal management of resources to deliver that care in each jurisdiction

    更新日期:2020-04-06
  • The COVID-19 Pandemic in the US: A Clinical Update
    JAMA (IF 51.273) Pub Date : 2020-04-06
    Saad B. Omer; Preeti Malani; Carlos del Rio

    Since the first US case of coronavirus disease 2019 (COVID-19) infection as identified in Washington State on January 20, 2020, more than 235 000 cases have been identified across the US in just over 2 months. Given the challenges in expanding testing capacity and the restrictive case definition of persons under investigation, the true number of cases is likely much higher. By March 17, the outbreak

    更新日期:2020-04-06
  • Sample Pooling as a Strategy to Detect Community Transmission of SARS-CoV-2
    JAMA (IF 51.273) Pub Date : 2020-04-06
    Catherine A. Hogan; Malaya K. Sahoo; Benjamin A. Pinsky
    更新日期:2020-04-06
  • Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy
    JAMA (IF 51.273) Pub Date : 2020-04-06
    Giacomo Grasselli; Alberto Zangrillo; Alberto Zanella; Massimo Antonelli; Luca Cabrini; Antonio Castelli; Danilo Cereda; Antonio Coluccello; Giuseppe Foti; Roberto Fumagalli; Giorgio Iotti; Nicola Latronico; Luca Lorini; Stefano Merler; Giuseppe Natalini; Alessandra Piatti; Marco Vito Ranieri; Anna Mara Scandroglio; Enrico Storti; Maurizio Cecconi; Antonio Pesenti
    更新日期:2020-04-06
  • Hundreds of Health Care Workers Exposed to Rabies
    JAMA (IF 51.273) Pub Date : 2020-03-24
    Bridget M. Kuehn
    更新日期:2020-04-06
  • Adults Are Making It Easier for Children to Ingest Dangerous Drugs
    JAMA (IF 51.273) Pub Date : 2020-03-24
    Bridget M. Kuehn
    更新日期:2020-04-06
  • Supporting colleagues during covid-19: the intensive care consultant
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Adrian O’Dowd

    Emma Wheatley, an intensive care medicine and anaesthesia consultant in Bolton, tells Adrian O’Dowd why it’s important to support colleagues so they can perform at their peak Any clinician who has ever felt unsupported could do no better than work with Emma Wheatley to boost their confidence and satisfaction in the workplace. As well as being a qualified coach and mentor she has been appointed a BMA

    更新日期:2020-04-06
  • Autoimmune complications of immunotherapy: pathophysiology and management
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Karmela K Chan; Anne R Bass

    Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that target inhibitory molecules, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1), or its ligand, programmed cell death protein ligand 1 (PD-L1), and lead to immune activation in the tumor micro-environment. ICIs can induce durable treatment responses in patients with advanced cancers

    更新日期:2020-04-06
  • Are UK doctors getting sufficient protective equipment against covid-19?
    BMJ (IF 27.604) Pub Date : 2020-04-03
    British Medical Journal Publishing Group

    We have amended this feature article ( BMJ 2020;369:m1297, …

    更新日期:2020-04-06
  • Health surveillance during covid-19 pandemic
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Rafael A Calvo; Sebastian Deterding; Richard M Ryan

    How to safeguard autonomy and why it matters Societies are responding to the covid-19 pandemic at breathtaking speed. Many of these ad hoc responses will have long lasting consequences, and we must make sure that today’s efforts do not threaten our future wellbeing. The most consequential transformations may come from new health surveillance technologies that use machine learning and automated decision

    更新日期:2020-04-06
  • Cardiopulmonary resuscitation after hospital admission with covid-19
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Zoë Fritz; Gavin D Perkins

    The balance of benefits and risks has changed, and practice must change with it In normal times, the medical obligation to “first do no harm” applies to the actions of individual doctors on individual patients. During pandemics, the ethical imperatives shift: we must consider the safety of not only the individual patient but also the clinician and the population. Guidelines on attempting cardiopulmonary

    更新日期:2020-04-06
  • Artificial intelligence versus clinicians
    BMJ (IF 27.604) Pub Date : 2020-04-03
    Vanessa Rampton

    Evolving technologies may yet provide the medicine that patients expect Could machines replace human physicians? Substantial private investments are being devoted to achieving exactly that, and some success has been reported in areas such as breast screening,1 fuelling desires among the public for accelerated implementation.2 The main argument of tech optimists is that deep learning AI systems, which

    更新日期:2020-04-06
  • Seattle’s covid-19 lessons are yielding hope
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Bryn Nelson

    The far north western corner of the continental US was hit early and hard. Bryn Nelson reports that the region now appears to be successfully climbing its way out of the epidemic Everything changed in Seattle on 28 February 2020. The metropolitan region of about 3.5 million people in Washington State had already documented the first US case of covid-19 on 20 January in a 35 year old man who had visited

    更新日期:2020-04-06
  • Lessons from covid-19: visiting patients at home and assessing comorbidities
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Anna M H Stevens

    What might we learn from the covid-19 pandemic?1 Before the pandemic, a patient with complex comorbidities who was unwell at home would have been visited by a general practitioner. This would sometimes be followed by a visit from a district nurse to check blood tests, a visit from a relative who needed to fetch medication from a pharmacy, a referral to the local Health Hub for …

    更新日期:2020-04-06
  • Covid-19 pandemic: a public and global mental health opportunity for social transformation?
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Ayesha Ahmad; Christoph Mueller; Konstantinos Tsamakis

    We know from analysing conflict and post-conflict transitions that such crises can pose as an opportunity for social transformation.1 Given the humanitarian challenges of the ongoing pandemic, we think that covid-19 needs a public mental health focus. Covid-19 is the first major pandemic of our generation,2 and we must seek the hidden opportunities to …

    更新日期:2020-04-06
  • Covid-19 and the rise of racism
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Melanie Coates

    Over the past few months covid-19 has dramatically changed how we live. The media and the government have rightly been concerned with the global health and economic implications of this pandemic,1 but they have neglected to acknowledge the simultaneous spread of prejudice and xenophobia. Fear leads to the desire to understand and control situations. From this we see a surge of prejudice and …

    更新日期:2020-04-06
  • Social distancing in covid-19: what are the mental health implications?
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Ashwin Venkatesh; Shantal Edirappuli

    As of 1 April 2020, there have been 29 474 confirmed cases of covid-19 in the UK.1 As discussed by Mahase, the UK government has enforced “social distancing” measures to curb transmission, protect the vulnerable, and prevent saturation of the NHS.2 Social distancing has potential mental health implications—how can we mitigate these to bolster this essential …

    更新日期:2020-04-06
  • Covid-19: Don’t apply advance care plans to groups of people, doctors’ leaders warn
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Gareth Iacobucci

    Medical leaders have said it is “unacceptable” for advance care plans—with or without a completed “Do not attempt to resuscitate” (DNAR) form—to be applied in a blanket manner to whole groups of people during the covid-19 pandemic.1 The joint statement from the Royal College of General Practitioners, BMA, Care Provider Alliance, and Care Quality Commission comes amid concern that GPs are feeling under

    更新日期:2020-04-06
  • Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
    Nat. Med. (IF 30.641) Pub Date : 2020-04-06
    Myriam Chalabi; Lorenzo F. Fanchi; Krijn K. Dijkstra; José G. Van den Berg; Arend G. Aalbers; Karolina Sikorska; Marta Lopez-Yurda; Cecile Grootscholten; Geerard L. Beets; Petur Snaebjornsson; Monique Maas; Marjolijn Mertz; Vivien Veninga; Gergana Bounova; Annegien Broeks; Regina G. Beets-Tan; Thomas R. de Wijkerslooth; Anja U. van Lent; Hendrik A. Marsman; Elvira Nuijten; Niels F. Kok; Maria Kuiper;
    更新日期:2020-04-06
  • Sixty seconds on . . . sofas
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Abi Rimmer

    Well, now maybe you can because two furniture retailers have been donating sofas to hospitals. Isn’t that amazing? Sorry, I got carried away. But Made and the DFS Group—which includes DFS, Sofology, Dwell, and Sofa Workshop—have donated sofas, sofabeds, and other items such as crockery to hospitals around the UK for …

    更新日期:2020-04-06
  • Americans are told to wear cloth masks
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Janice Hopkins Tanne

    The US Centers for Disease Control and Prevention (CDC) has told Americans to wear cloth masks to prevent coronavirus transmission. President Donald Trump said at a press briefing last week that the advice was voluntary, and he was choosing not to wear one. Trump said that the next week or two would be bad and there would be many deaths. The pandemic is expected to peak in the next week or two in New

    更新日期:2020-04-06
  • Antisense oligonucleotides for atherosclerotic disease
    Nat. Med. (IF 30.641) Pub Date : 2020-04-06
    Archna Bajaj; Daniel J. Rader
    更新日期:2020-04-06
  • Covid-19: NICE advises against using NSAIDs for fever in patients with suspected cases
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Ingrid Torjesen

    Paracetamol should be used in preference to non-steroidal anti-inflammatory drugs for managing fever in patients with suspected covid-19 until more evidence is available on the safety of NSAIDs, the National Institute for Health and Care Excellence advises in a rapid guideline on managing symptoms of covid-19 in the community.1 Patients with cough symptoms should take honey and avoid lying on their

    更新日期:2020-04-06
  • Covid-19: UK government writes off £13.4bn of hospital debts to ease pressures
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Gareth Iacobucci

    Over 100 NHS hospitals have had a combined £13.4bn (€15.25bn; $16.48bn) in historical debts written off by the government to help them respond to the covid-19 pandemic. The move, effective from 1 April, was announced by England’s health secretary, Matt Hancock, on 2 April as part of a wider package of measures designed to give trusts financial support during the pandemic and help them achieve longer

    更新日期:2020-04-06
  • Neoadjuvant immune-checkpoint blockade in resectable colon cancer
    Nat. Med. (IF 30.641) Pub Date : 2020-04-06
    George Coukos
    更新日期:2020-04-06
  • Women whose cervical cancer was missed can have surrogacy abroad paid for by the NHS
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Clare Dyer

    The NHS can be ordered to pay for surrogacy treatment abroad if a hospital’s negligence leaves a woman infertile, the UK Supreme Court has ruled in a landmark judgment. By a 3-2 majority, the court decided that it would not be against public policy to allow a woman who developed cervical cancer after several smear tests and biopsies were wrongly interpreted to be awarded damages covering surrogacy

    更新日期:2020-04-06
  • Stroke: “striking reductions” are seen in number of people with symptoms seeking help
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Jacqui Thornton

    People are ignoring stroke symptoms and failing to ring 999 because they fear being a burden on the NHS in England during the covid-19 pandemic, the national clinical director for stroke has warned. Deb Lowe, consultant stroke physician at Wirral University Teaching Hospital, said that doctors across the country were seeing “quite striking reductions” in the number of people coming into hospital with

    更新日期:2020-04-06
  • All ranitidine should be discarded, says US drug agency
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Owen Dyer

    The heartburn and stomach ulcer drug Zantac (ranitidine) and its generic equivalent should be removed from pharmacy shelves and should be discarded if found at home, the US Food and Drug Administration has said. The agency cited new findings from its analysis of stockpiled ranitidine, which showed that levels of the probable carcinogen N-nitrosodimethylamine (NDMA) increased over time in the drug during

    更新日期:2020-04-06
  • Covid-19: A&E visits in England fall by 25% in week after lockdown
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Jacqui Thornton

    Attendances at emergency departments in England have fallen significantly since the covid-19 lockdown, sparking concern that some people may be harmed by not accessing treatment. The Royal College of Emergency Medicine said that the public should not be frightened of going to emergency departments after figures showed that they saw 89 584 attendances in the week after the lockdown (March 23-29), down

    更新日期:2020-04-06
  • Covid-19: PHE upgrades PPE advice for all patient contacts with risk of infection
    BMJ (IF 27.604) Pub Date : 2020-04-03
    Anna Sayburn

    New guidelines on use of personal protective equipment (PPE) by healthcare workers significantly expands the potential use of eye protection and fluid resistant surgical masks, including to doctors carrying out face-to-face assessments where a patient’s risk of covid-19 is unknown.1 The updated guidance from Public Health England, which is in line with World Health Organization recommendations, allows

    更新日期:2020-04-06
  • Pedometers can help people get more active as part of an exercise programme
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Rob Cook; Peter Davidson; Rosie Martin

    Hodkinson A, Kontopantelis E, Adeniji C, et al. Accelerometer- and pedometer-based physical activity interventions among adults with cardiometabolic conditions: a systematic review and meta-analysis. JAMA Network Open 2019;2:e1912895. This study was funded by the NIHR School for Primary Care Research (project number 390 ESWG Workstream 3). To read the full NIHR Signal, go to: https://discover.dc.nihr

    更新日期:2020-04-06
  • Prehabilitation could save lives in a pandemic
    BMJ (IF 27.604) Pub Date : 2020-04-06
    Julie K Silver

    Let’s use best practice prehabilitation to improve patients’ health before the upcoming “battle” Prehabilitation involves interventions aimed at improving patients’ health before an anticipated upcoming physiologic stressor so that they are better able to withstand that stress. Prehabilitation emerged as a way to prepare soldiers for battle in the second world war. A study published in 1946 in The

    更新日期:2020-04-06
  • Urgent dental care for patients during the COVID-19 pandemic
    Lancet (IF 59.102) Pub Date : 2020-04-03
    Manas Dave; Noha Seoudi; Paul Coulthard

    During the initial phase of a pandemic, when a vaccine is not available, personal protective equipment (PPE) plays a major part in disease control. Dental and oral surgery procedures using drills or ultrasonic devices cause aerosol release, and routine dentistry has therefore been suspended in several countries, including the UK, to reduce virus transmission. There is an urgent need for organised emergency

    更新日期:2020-04-06
  • Governmental Public Health Powers During the COVID-19 Pandemic: Stay-at-home Orders, Business Closures, and Travel Restrictions
    JAMA (IF 51.273) Pub Date : 2020-04-02
    Lawrence O. Gostin; Lindsay F. Wiley

    The president and all 50 governors have declared health emergencies to counteract the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19). While researchers race to develop vaccines, officials are implementing physical distancing, including orders to stay at home, restricting travel, and closing nonessential businesses (see eFigure

    更新日期:2020-04-03
  • Personal Risk and Societal Obligation Amidst COVID-19
    JAMA (IF 51.273) Pub Date : 2020-04-03
    Cynthia Tsai

    I grew up as a fiercely atopic kid with red rashes and watery eyes. I would wheeze when I played sports or when I got a cold. During college, my asthmatic lungs faced the East Coast nemesis called winter. Nowadays, I seek urgent care a couple times yearly for asthma exacerbations, and last winter, I found myself hospitalized with influenza A. I needed bilevel positive airway pressure (BiPAP) for a

    更新日期:2020-04-03
  • Addressing Social Determinants of Health: Time for a Polysocial Risk Score
    JAMA (IF 51.273) Pub Date : 2020-04-03
    Jose F. Figueroa; Austin B. Frakt; Ashish K. Jha

    What determines health? For decades, researchers have attempted to quantify the exact contribution of social factors, such as income, education, race/ethnicity, and the community environment, to health. The motivation is simple: understanding which social factors most affect health would help prioritize societal investments in those areas. However, most efforts to precisely quantify the influence of

    更新日期:2020-04-03
  • The Role of Physicians in Addressing Social Determinants of Health
    JAMA (IF 51.273) Pub Date : 2020-04-03
    Nason Maani; Sandro Galea

    To a large degree, health is shaped by the conditions in which people are born, grow, live, work, and age, collectively termed the social determinants of health.1,2 US public and health care professionals care about improving health outcomes. Compared with other high-income countries, the US spends significantly more per capita and in total on health care.3 Yet through chronic underinvestment in some

    更新日期:2020-04-03
  • How can I keep calm during self-isolation?
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Abi Rimmer

    On top of the stress of work, there are now additional pressures to deal with at home, especially if you are self-isolating. Abi Rimmer asks experts how best to manage these Adam Dobson, head of early years foundation stage at Thames View Infants School, Barking, says, “As an early years teacher, and a parent of a five year old, I’ve experienced the difficulty in trying to recreate the classroom at

    更新日期:2020-04-03
  • Machine learning and artificial intelligence research for patient benefit: 20 critical questions on transparency, replicability, ethics, and effectiveness
    BMJ (IF 27.604) Pub Date : 2020-04-01
    British Medical Journal Publishing Group

    An error was included in the accepted version of this paper by Vollmer and colleagues ( BMJ 2020;368:l6927, doi:10.1136/bmj.l6927 …

    更新日期:2020-04-03
  • Protect our healthcare workers
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Fiona Godlee

    For healthcare staff at the front line of the covid-19 pandemic, work has suddenly become a frightening place. Impossible decisions threaten long term psychological damage from moral injury, say Neil Greenberg and colleagues (doi:10.1136/bmj.m1211). And there is real and justified fear about personal safety, fuelled by a scandalous and widespread lack of personal protective equipment (PPE). Doctors

    更新日期:2020-04-03
  • Covid-19: how a virus is turning the world upside down
    BMJ (IF 27.604) Pub Date : 2020-04-03
    Ilona Kickbusch; Gabriel M Leung; Zulfiqar A Bhutta; Malebona Precious Matsoso; Chikwe Ihekweazu; Kamran Abbasi

    We may emerge from this with a healthier respect for our common humanity The covid-19 pandemic is the biggest threat in living memory to health and wellbeing, social welfare, and the global economy. In a world shaped by neoliberalism the economy has always come first, but many leaders of rich countries are now explicitly prioritising people’s health over the economy. On 26 March, G20 leaders held an

    更新日期:2020-04-03
  • Money injection for public services
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Richard Murray

    Where should we direct these precious extra resources? On 11 March, Rishi Sunak, the chancellor of the exchequer, presented his first budget and promised an extra £5bn (€5.7bn; $6.2bn) for public services to help them deal with covid-19.1 What is the £5bn for? £1.6bn is going to local authorities to support social care, social care staff, and the vulnerable. £1.3bn is going to support quicker discharge

    更新日期:2020-04-03
  • Drugs and the renin-angiotensin system in covid-19
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Jeffrey K Aronson; Robin E Ferner

    Clinical effects are unpredictable, so treatment decisions must be tailored and pragmatic Covid-19, which is caused by the single stranded RNA coronavirus SARS-CoV-2, poses therapeutic dilemmas. Some suggestions for drug treatment seem problematic.1 They include various antiviral drugs, some of which have primary targets that are DNA viruses not RNA; immunomodulatory drugs, which may suppress potentially

    更新日期:2020-04-03
  • Comparative weight loss with popular diets
    BMJ (IF 27.604) Pub Date : 2020-04-01
    Helen Truby; Terry P Haines

    Choice of diet is less important than maintaining any weight loss achieved As most adults in many developed countries are above a healthy weight,1 it is not surprising that the problem of obesity has led to considerable commercial interest in providing solutions. In the United States, the commercial weight loss market is estimated to be worth $72bn (£60bn; €66bn) annually.2 Commercialisation of dietary

    更新日期:2020-04-03
  • Covid-19: the crisis of personal protective equipment in the US
    BMJ (IF 27.604) Pub Date : 2020-04-03
    Douglas Kamerow

    Shortages are occurring amid widely varying demand, use, and supply strategies, Douglas Kamerow finds As covid-19 makes its way through the US, in some locations doctors, nurses, and other healthcare workers are facing the frightening prospect of work without personal protective equipment (PPE). A national survey of hospital infection control professionals reported that many medical facilities are

    更新日期:2020-04-03
  • Are UK doctors getting sufficient protective equipment against covid-19?
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Anna Sayburn

    The BMA has warned that doctors are at risk of serious illness or even death because of a lack of proper personal protective equipment (PPE). To determine the vulnerability of healthcare workers on the front line, we look at what the latest guidelines recommend and the evidence behind the use of different grades of equipment, from surgical face masks to full PPE. Are doctors and other healthcare workers

    更新日期:2020-04-03
  • The BMJ Awards 2020: Environmental sustainability and climate action
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Matthew Limb

    Teams across the UK are coming up with innovative ways to combat the climate emergency, finds Matthew Limb The NHS has a “moral obligation” to reduce the harmful effects on health from its activities, says James Dixon, head of sustainability for Newcastle upon Tyne Hospitals NHS Foundation Trust. He proposed that the trust should agree to publicly declare a “climate emergency” and fast track a reduction

    更新日期:2020-04-03
  • The BMJ Awards 2020: Digital innovation
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Matthew Limb

    Nominees for the digital innovation award have found new ways to simplify and improve patient care, says Matthew Limb High blood pressure is the biggest remedial cause of stroke or myocardial infarction. Around 12 million attendances at general practitioner surgeries each year are for blood pressure checks. Checks done at home by patients are more accurate than those done in the surgery, but self monitoring

    更新日期:2020-04-03
  • Covid-19: Can France’s ethical support units help doctors make challenging decisions?
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Sophie Arie

    France has set up “ethical support units” to help doctors make difficult choices about which patients with covid-19 to treat in intensive care. Sophie Arie reports With more than 2600 deaths and 40 000 cases of covid-19 recorded in France, hospitals in the Ile de France region surrounding Paris have been preparing for a tipping point in the week beginning Monday 30 March, when their 2000 intensive

    更新日期:2020-04-03
  • Regional coordination and bottom-up response of general practitioners in Belgium and the Netherlands
    BMJ (IF 27.604) Pub Date : 2020-04-03
    Josefien van Olmen; Roy Remmen; Paul Van Royen; Hilde Philips; Veronique Verhoeven; Sibyl Anthierens

    General practitioners are at the core of the healthcare response to the emerging covid-19 epidemic in European health systems.1 The coordination of primary care differs across countries; we describe the response in Belgium and the Netherlands. In the initial phase, central public health authorities developed a national protocol for screening and case finding. In the Netherlands, decentralised municipal

    更新日期:2020-04-03
  • Managing clinical trials for covid-19: the importance of ethics committees
    BMJ (IF 27.604) Pub Date : 2020-04-03
    Qiankun Luo; Tao Qin

    In the global outbreak of covid-19, people are self-isolating at home, cities are blocked, and schools, museums, and stores are closed.1 Medical students and retired doctors are convened to deal with covid-19,23 but there are still no effective drugs or vaccines. The World Health Organization’s 2016 guidance on ethical issues in infectious diseases …

    更新日期:2020-04-03
  • Covid-19 worldwide: we need precise data by age group and sex urgently
    BMJ (IF 27.604) Pub Date : 2020-04-03
    Raj Bhopal

    Accurate and interpretable data are essential in guiding our approach to the covid-19 pandemic. Basic epidemiological principles are currently being flouted.1 Mostly, as in your article,2 case numbers are being reported. This number needs to be converted to a proportion, using the population size as the denominator. Otherwise, how can we tell which countries are …

    更新日期:2020-04-03
  • Fighting covid-19 outbreaks in prisons
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Hong Yang; Julian R Thompson

    Poor prison healthcare has been reported by Armstrong.1 Improving prison health services is critical for fighting epidemics such as covid-19. On 20 February 2020, over 500 new covid-19 cases in five prisons ended 16 days of continuous decline in new cases in China (excluding Hubei province).2 Over half were in Hubei, including 230 at Wuhan Women’s Prison and 41 at …

    更新日期:2020-04-03
  • Ministry of Justice comment on “The prison service is still failing inmates’ healthcare needs”
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Stephen Armstrong

    The BMJ contacted the Ministry of Justice for comment on this story and received the comment too …

    更新日期:2020-04-03
  • Safety of referred doctors: All doctors are human and therefore vulnerable
    BMJ (IF 27.604) Pub Date : 2020-04-02
    John Dean

    This Week, 7 March I read this news story1 with great sadness. A systemic failure has led to the suicide of a doctor fearing the loss of his livelihood, public disgrace, and humiliation based …

    更新日期:2020-04-03
  • Cooperation as an alternative to nationalisation of the pharmaceutical industry
    BMJ (IF 27.604) Pub Date : 2020-04-02
    Jonathan R Denfhy

    Head to Head, 7 March Serial title in print: Drug industry debate Mazzucato and Li, and Darzi provide compelling arguments for and against the nationalisation of the pharmaceutical industry.1 Mazzucato and Li’s argument regarding the “short termism and misalignment of public interest” are justified criticisms of big pharma, and Darzi’s counter on the singular financial power that these companies wield

    更新日期:2020-04-03
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