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Somatic Mutations: The Next Frontier in Demystifying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis? Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-12-01 Xiting Yan,Naftali Kaminski
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Reply to Neder, to Ogata et al., and to Graham. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-30 Surya P Bhatt,Arie Nakhmani,Spyridon Fortis,Matthew J Strand,Edwin K Silverman,Frank C Sciurba,Sandeep Bodduluri
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Novel FEV1/FVC-based Diagnosis and Severity Classification of Chronic Obstructive Pulmonary Disease: How About FEV1 Percent Predicted Basing? Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-30 Hiroaki Ogata,Yasuyoshi Washio,Makoto Yoshida
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Use FEV1/FVC Z-Score Staging to Minimize Sex and Age Bias in Staging Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-30 Brian L Graham
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Determining the Architecture of Inflammation in Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-30 Sudarshan Rajagopal,Yen-Rei Yu
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Is This Really a New START in COPD? Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-30 J Alberto Neder
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Hematocrit: The Neglected Variable of Extracorporeal CO2 Removal. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-30 Luigi Vivona,Michele Battistin,Eleonora Carlesso,Gaetano Florio,Serena Todaro,Sebastiano M Colombo,Francesco Zadek,Giacomo Grasselli,Alberto Zanella,Thomas Langer
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An Update on Management of Adult Patients with Acute Respiratory Distress Syndrome: An Official American Thoracic Society Clinical Practice Guideline. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-30 Nida Qadir,Sarina Sahetya,Laveena Munshi,Charlotte Summers,Darryl Abrams,Jeremy Beitler,Giacomo Bellani,Roy G Brower,Lisa Burry,Jen-Ting Chen,Carol Hodgson,Catherine L Hough,Francois Lamontagne,Anica Law,Laurent Papazian,Tai Pham,Eileen Rubin,Matthew Siuba,Irene Telias,Setu Patolia,Dipayan Chaudhuri,Allan Walkey,Bram Rochwerg,Eddy Fan
BACKGROUND This document updates previously published Clinical Practice Guidelines for the management of patients with acute respiratory distress syndrome (ARDS), incorporating new evidence addressing the use of corticosteroids, venovenous extracorporeal membrane oxygenation, neuromuscular blocking agents, and positive end-expiratory pressure (PEEP). METHODS We summarized evidence addressing four "PICO
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Deciphering Mechanisms of Respiratory Foetal-to-Neonatal Transition in Very Preterm Infants. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-30 Vincent D Gaertner,Vanessa L Büchler,Andreas Waldmann,Dirk Bassler,Christoph M Rüegger
RATIONALE The respiratory mechanisms of a successful transition of preterm infants after birth are largely unknown. OBJECTIVES To describe intrapulmonary gas flows during different breathing patterns directly after birth Methods: Analysis of electrical impedance tomography (EIT) data from a previous randomized trial in preterm infants 26-32 weeks gestational age. EIT data for individual breaths were
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Can Four-Dimensional CT Assess Dynamic Changes in Lung Volumes in Mechanically Ventilated Patients? Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-29 Shinshu Katayama,Ken Tonai,Kie Nakamura,Misuzu Tsuji,Shinichiro Uchimasu,Atsuko Shono,Masamitsu Sanui
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Respiratory Metagenomics: Ready for Prime Time? Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-29 Emily Lydon,Charles R Langelier
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Occupational Benzene Exposure: An Unrecognized Threat to Lung Cancer Development. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-29 Katrina Steiling,Hasmeena Kathuria
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Prevalence, Diagnostic Utility and Associated Characteristics of Bronchodilator Responsiveness. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-29 Richard Beasley,Rod Hughes,Alvar Agusti,Peter Calverley,Bradley Chipps,Ricardo Del Olmo,Alberto Papi,David Price,Helen Reddel,Hana Mullerova,Eleni Rapsomaniki
BACKGROUND The prevalence and diagnostic utility of bronchodilator responsiveness (BDR) in a real-life setting is unclear. We explored this uncertainty in patients aged ≥12 years with physician-assigned diagnoses of asthma, asthma and COPD, or COPD in NOVELTY, a prospective cohort study in primary and secondary care in 18 countries. METHODS The proportion of patients with a positive BDR test in each
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Ambient Ultrafine Particulate Matter and Clinical Outcomes in Fibrotic Interstitial Lung Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-29 Gillian C Goobie,Provat K Saha,Christopher Carlsten,Kevin F Gibson,Kerri A Johannson,Daniel J Kass,Christopher J Ryerson,Yingze Zhang,Allen L Robinson,Albert A Presto,S Mehdi Nouraie
RATIONALE Particulate matter ≤2.5μm (PM2.5) is associated with adverse outcomes in fibrotic interstitial lung disease (fILD), but the impact of ultrafine particulates (UFPs; aerodynamic diameter ≤100nm) remains unknown. OBJECTIVE To evaluate UFP associations with clinical outcomes in fILD. METHODS Multicenter, prospective cohort study enrolling patients with fILD from the University of Pittsburgh Simmons
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Household Air Pollution and Child Lung Function: The Ghana Randomized Air Pollution and Health Study. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-28 Prince Darko Agyapong,Darby Jack,Seyram Kaali,Elena Colicino,Mohammed Nuhu Mujtaba,Steven N Chillrud,Musah Osei,Chris Gennings,Oscar Agyei,Patrick L Kinney,Adolphine Kwarteng,Matthew Perzanowski,Rebecca Kyerewaa Dwommoh Prah,Theresa Tawiah,Kwaku Poku Asante,Alison G Lee
RATIONALE The impact of a household air pollution (HAP) stove intervention on child lung function is poorly described. OBJECTIVES To assess the effect of a prenatal to age one HAP stove intervention on, and exposure-response associations with, age four lung function. METHODS The Ghana Randomized Air Pollution and Health Study (GRAPHS) randomized pregnant women to a liquefied petroleum gas (LPG), improved
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Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non-Cystic Fibrosis Bronchiectasis (NCFB). Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-28 Takanori Asakura,Kenichi Okuda,Gang Chen,Hong Dang,Takafumi Kato,Yu Mikami,Stephen A Schworer,Rodney C Gilmore,Giorgia Radicioni,Padraig Hawkins,Selene Margarita Barbosa Cardenas,Minako Saito,Anne Marie Cawley,Gabriela De la Cruz,Michael Chua,Neil E Alexis,Yohei Masugi,Peadar G Noone,Carla M P Ribeiro,Mehmet Kesimer,Kenneth N Olivier,Naoki Hasegawa,Scott H Randell,Wanda K O'Neal,Richard C Boucher
Rationale: Non-cystic fibrosis bronchiectasis (NCFB) may originate in bronchiolar regions of the lung. Accordingly, there is a need to characterize the morphology and molecular characteristics of NCFB bronchioles. Objective: Test the hypothesis that NCFB exhibits a major component of bronchiolar disease manifest by mucus plugging and ectasia. Methods: Morphologic criteria and region-specific epithelial
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Association Between T2-related Comorbidities and Effectiveness of Biologics in Severe Asthma. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-28 Michael E Wechsler,Ghislaine Scelo,Désirée E S Larenas-Linnemann,Carlos A Torres-Duque,Jorge Maspero,Trung N Tran,Ruth B Murray,Neil Martin,Andrew N Menzies-Gow,Mark Hew,Matthew J Peters,Peter G Gibson,George C Christoff,Todor A Popov,Andréanne Côté,Celine Bergeron,Delbert Dorscheid,J Mark FitzGerald,Kenneth R Chapman,Louis Philippe Boulet,Mohit Bhutani,Mohsen Sadatsafavi,Libardo Jiménez-Maldonado
RATIONALE Previous studies investigating comorbidity impact on biologic effectiveness have been relatively small, of short duration, and have not compared biologic classes. OBJECTIVES To determine the association between T2-related comorbidities and biologic effectiveness in adults with severe asthma (SA). METHODS This cohort study used International Severe Asthma Registry data (n=21 countries, 2017-2022)
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Our Scientific Journey through the Ups and Downs of Blood Glucose Control in the ICU. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-22 Greet Van den Berghe,Ilse Vanhorebeek,Lies Langouche,Jan Gunst
This article tells the story of our long search for the answer to one question: is stress hyperglycemia in critically illness adaptive or mal-adaptive? Our earlier work had suggested lack of hepatic insulin effect and hyperglycemia jointly predicting poor outcome. We therefore hypothesized that insulin infusion to reach normoglycemia, tight-glucose-control, improves outcome. In 3 RCTs, we found morbidity
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Right Atrial Angiosarcoma with Embolic Lung Metastases Masquerading as Atypical Pneumonitis. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-22 Chung-Fu Lin,Yu-Wei Wu,Wei-An Liao,Chia-Ying Lin,Ying-Tzu Huang,Tang-Hsiu Huang
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Reply to: The Challenges of Using and Measuring Thiamine in Critical Care. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Ari Moskowitz
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The Challenges of Using and Measuring Thiamine in Critical Care. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Muhammad Ashraful Mumin,Cathrine Anne McKenzie,Peter Erwin Spronk
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Reply to: Candidacy for ECMO Should Start with Ventilatory Support Optimization. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Darya Rudym,Tài Pham,Craig R Rackley,Giacomo Grasselli,Matthieu Schmidt,Daniel Brodie
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Effects of Positive End-Expiratory Pressure on Artery Coronary Flow in Patients With Acute Respiratory Distress Syndrome. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Yoann Zerbib,Rosalie Schoux,Jack Richecoeur,Thomas Bradier,Clément Brault,Loay Kontar,Alexis Lambour,Julien Maizel,Michel Slama
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Candidacy for ECMO Should Start with Ventilatory Support Optimization. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Francesco Zadek,Lorenzo Berra,Jamel Ortoleva
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Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an ARDS Model. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Saira Ahmad,Joe A Wrennall,Alexandra S Goriounova,Malika Sekhri,Jason A Iskarpatyoti,Arunava Ghosh,Sabri H Abdelwahab,Alexis Voeller,Mani Rai,Rahul Y Mahida,Krzysztof Krajewski,Diane M Ignar,Alon Greenbaum,Timothy P Moran,Stephen L Tilley,David R Thickett,M Flori Sassano,Robert Tarran
Rationale: Acute Respiratory Distress Syndrome (ARDS) has an unacceptably high mortality rate (35%) and is without effective therapy. Orai1 is a Ca2+ channel involved in store operated Ca2+ entry (SOCE), a process that exquisitely regulates inflammation. Orai1 is considered a druggable target, but to date, no Orai1-specific inhibitors exist. Objectives: To evaluate whether ELD607, a first-in-class
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Fungal Fog in Viral Storms: Necessity for Rigor in Aspergillosis Diagnosis and Research. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Simon Feys,Martin Hoenigl,Jean-Pierre Gangneux,Paul E Verweij,Joost Wauters
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Larger Mediastinal Lymph Nodes Are Associated with Worse Lung Function in Persistent Asthma. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Rory Chan,Chary Duraikannu,Mohamed Jaushal Thouseef,Brian Lipworth
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Diagnostic Potential of Oscillometry: A Population-based Approach. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Chiara Veneroni,Christoph Valach,Emiel F M Wouters,Alessandro Gobbi,Raffaele L Dellacà,Marie-Kathrin Breyer,Sylvia Hartl,Owat Sunanta,Charles G Irvin,Caspar Schiffers,Pasquale Pio Pompilio,Robab Breyer-Kohansal
RATIONALE Respiratory resistance (Rrs) and reactance (Xrs) measured by oscillometry and their intra-breath changes have emerged as sensitive parameters for detecting early pathological impairments during tidal breathing. OBJECTIVES This study evaluates the prevalence and association of abnormal oscillometry parameters with respiratory symptoms and respiratory diseases in a general adult population
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Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-16 Shanshan Song,Fransien van Dijk,Gwenda F Vasse,Qiongliang Liu,Irene F Gosselink,Ellen Weltjens,Alex Hv Remels,Marina H de Jager,Sophie Bos,Chenxi Li,Tobias Stoeger,Markus Rehberg,David Kutschke,Gail van Eck,Xinhui Wu,Suzanne H Willems,Devin Boom,Ingeborg M Kooter,Diana Spierings,Rene Wardenaar,Matthew Cole,Martijn C Nawijn,Anna Salvati,Reinoud Gosens,Barbro N Melgert
RATIONALE Microplastics are a pressing global concern and inhalation of microplastic fibers has been associated with interstitial and bronchial inflammation in flock workers. However, how microplastic fibers affect the lungs is unknown. OBJECTIVES Our aim was to assess the effects of 12x31 µm nylon 6,6 (nylon) and 15x52 µm polyethylene terephthalate (polyester) textile microplastic fibers on lung epithelial
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Research Accomplishments in Pulmonary, Critical Care and Sleep: A Retrospective Review. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 James P Kiley,Marishka K Brown,Michelle Freemer,Sara Lin,Mihaela Stefan,Patricia Noel
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Icenticaftor, a Novel Treatment for Chronic Obstructive Pulmonary Disease, Needs Further Verification of Its Effectiveness. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Qiming Gan,Kai Yang,Yanjuan Wu,Jingcun Wang,Haojie Zhang,Nuofu Zhang,Kang Wu
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Uncovering the Complexities of IL-33 Signaling in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Felicity A Easton,David J Cousins
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Role of Community Health Workers in Chronic Obstructive Pulmonary Disease Care in Low- and Middle-Income Countries. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Sundeep Salvi,Deesha Ghorpade
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Who Drives the Chronic Obstructive Pulmonary Disease Bus? Protease-Rich Extracellular Vesicles in Cigarette Smoke-associated Alveolar Damage. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Vaughn D Craddock,Navneet K Dhillon
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Recognizing and Managing the Burdens of Chronic Breathlessness Alongside the Burdens of Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 David C Currow,Rajam Iyer,Joseph Clark,Sujeet K Rajan
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E-Cigarettes as a Smoking Cessation Aid - Toward Common Ground and a Rational Approach. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Nicholas S Hopkinson
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Microbiological Monitoring in Therapeutic Trials in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Miguel Angel Martinez-Garcia,Alvar Agusti
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Reply to Martinez-Garcia et al. and to Wang et al. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 James P Allinson,Ben H Vlies,Simon E Brill,Martin Law,Girvan Burnside,Lydia J Finney,Luana Alves-Moreira,Peter M A Calverley,Paul P Walker,Jadwiga A Wedzicha
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Long-Term Doxycycline Therapy for Stable Chronic Obstructive Pulmonary Disease: Do the Benefits Outweigh the Drawbacks? Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Jingcun Wang,Qiming Gan,Haojie Zhang,Qiuyun Xing,Yanjuan Wu,Xiaofen Su,Nuofu Zhang,Kang Wu
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Protease-armed, Pathogenic Extracellular Vesicles Link Smoking and Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Matthew C Madison,Camilla Margaroli,Kristopher R Genschmer,Derek W Russell,James M Wells,Ezgi Sari,Yixel M Soto-Vazquez,Yuan-Yuan Guo,Kyle T Mincham,Robert J Snelgrove,Amit Gaggar,James E Blalock
Rationale: Mounting evidence demonstrates a role for extracellular vesicles (EVs) in driving lung disorders, such as chronic obstructive pulmonary disease (COPD). Although cigarette smoke (CS) is the primary risk factor for COPD, a link between CS and the EVs that could lead to COPD is unknown. Objective: To ascertain whether exposure to CS elicits a proteolytic EV signature capable of driving disease
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IL-33 Expression Is Lower in Current Smokers at both Transcriptomic and Protein Levels. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Alen Faiz,Rashad M Mahbub,Fia Sabrina Boedijono,Milan I Tomassen,Wierd Kooistra,Wim Timens,Martijn Nawijn,Philip M Hansbro,Matt D Johansen,Simon D Pouwels,Irene H Heijink,Florian Massip,Maria Stella de Biase,Roland F Schwarz,Ian M Adcock,Kian F Chung,Anne van der Does,Pieter S Hiemstra,Helene Goulaouic,Heming Xing,Raolat Abdulai,Emanuele de Rinaldis,Danen Cunoosamy,Sivan Harel,David Lederer,Michael
Rationale: IL-33 is a proinflammatory cytokine thought to play a role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). A recent clinical trial using an anti-IL-33 antibody showed a reduction in exacerbation and improved lung function in ex-smokers but not current smokers with COPD. Objectives: This study aimed to understand the effects of smoking status on IL-33. Methods:
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Investigating a Causal Role for Lung Microbiome Dysbiosis in Early Chronic Obstructive Pulmonary Disease Pathogenesis. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Alexa A Pragman
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Chronic Obstructive Pulmonary Disease Self-Management in Three Low- and Middle-Income Countries: A Pilot Randomized Trial. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Suzanne L Pollard,Trishul Siddharthan,Shakir Hossen,Natalie A Rykiel,Oscar Flores-Flores,Patricia Alupo,Shumonta Quaderi,Ivonne Ascencio,Julie A Barber,Ram Chandyo,Santa K Das,Gonzalo Gianella,Bruce Kirenga,Kelli Grunstra,J Jaime Miranda,Sakshi Mohan,Federico Ricciardi,Arun K Sharma,Laxman Shrestha,Marta O Soares,Adaeze C Wosu,John R Hurst,William Checkley,
Objectives: Chronic obstructive pulmonary disease (COPD) disproportionately affects low- and middle-income countries. Health systems are ill prepared to manage the increase in COPD cases. Methods: We performed a pilot effectiveness-implementation randomized field trial of a community health worker (CHW)-supported, 1-year self-management intervention in individuals with COPD grades B-D. The study took
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England Is Handing out E-Cigarettes: Is the "Swap to Stop" Tobacco Control Scheme Harm Reduction or Harm Production? Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Adam Edward Lang,Hasmeena Kathuria,Alain Braillon,Gary Ewart,Elif Dagli,Evan L Stepp,Panagis Galiatsatos,Janaki Deepak,Sven E Jordt,Don Hayes
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Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Imran Sulaiman,Benjamin G Wu,Matthew Chung,Bradley Isaacs,Jun-Chieh J Tsay,Meredith Holub,Clea R Barnett,Benjamin Kwok,Matthias C Kugler,Jake G Natalini,Shivani Singh,Yonghua Li,Rosemary Schluger,Joseph Carpenito,Destiny Collazo,Luisanny Perez,Yaa Kyeremateng,Miao Chang,Christina D Campbell,Philip M Hansbro,Beno W Oppenheimer,Kenneth I Berger,Roberta M Goldring,Sergei B Koralov,Michael D Weiden,Rui
Rationale: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and healthcare costs. Cigarette smoke is a causative factor; however, not all heavy smokers develop COPD. Microbial colonization and infections are contributing factors to disease progression in advanced stages. Objectives: We investigated whether lower airway dysbiosis occurs in mild-to-moderate COPD
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Improving Outcomes of Chronic Obstructive Pulmonary Disease through the Treatment of Comorbidities: One Step Beyond. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Marc Miravitlles
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Intercostal Recession and Bulging during Pendelluft Detected in Four-Dimensional Computed Tomography. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Shinshu Katayama,Ken Tonai,Shono Atsuko
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Association of GLP-1 Receptor Agonists with Chronic Obstructive Pulmonary Disease Exacerbations among Patients with Type 2 Diabetes. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Dinah Foer,Zachary H Strasser,Jing Cui,Katherine N Cahill,Joshua A Boyce,Shawn N Murphy,Elizabeth W Karlson
Rationale: Patients with chronic obstructive pulmonary disease (COPD) and type 2 diabetes (T2D) have worse clinical outcomes compared with patients without metabolic dysregulation. GLP-1 (glucagon-like peptide 1) receptor agonists (GLP-1RAs) reduce asthma exacerbation risk and improve FVC in patients with COPD. Objectives: To determine whether GLP-1RA use is associated with reduced COPD exacerbation
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Genetic and Epigenetic Associations with Pre-Chronic Obstructive Pulmonary Disease Lung Function Trajectories. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 David J Martino,Dinh S Bui,Shuai Li,Sabrina Idrose,Jennifer Perret,Adrian J Lowe,Caroline J Lodge,Gayan Bowatte,Yuben Moodley,Paul S Thomas,Graeme Zosky,Philip M Hansbro,John W Holloway,Cecilie Svanes,Rosa Faner,Eugene H Walters,Shaymali C Dharmage
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Health-related Quality of Life in Alpha-1 Antitrypsin Deficiency-associated Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Radmila Choate,Kristen E Holm,Robert A Sandhaus,David M Mannino,Charlie Strange
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Phenotypes, Etiotypes, and Endotypes of Exacerbations of Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Surya P Bhatt,Alvar Agusti,Mona Bafadhel,Stephanie A Christenson,Jessica Bon,Gavin C Donaldson,Don D Sin,Jadwiga A Wedzicha,Fernando J Martinez
Chronic obstructive pulmonary disease is a major health problem with a high prevalence, a rising incidence, and substantial morbidity and mortality. Its course is punctuated by acute episodes of increased respiratory symptoms, termed exacerbations of chronic obstructive pulmonary disease (ECOPD). ECOPD are important events in the natural history of the disease, as they are associated with lung function
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Indoor Air Pollution and Lung Function Decline: "Should I Stay or Should I Go?" Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Sara De Matteis
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Going Down, Dooby Doo Down, Down: Identifying Rapid Spirometry Decline. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-15 Andrew Bush
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Paradoxical Response to Standardized Chest Loading May Unveil Occult Overdistension During Protective Ventilation. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-13 Elsa Moncomble,Samuel Tuffet,Mohamed Boujelben,Ségolène Gendreau,Pascale Labedade,Anne-Fleur Haudebourg,Armand Mekontso Dessap,Guillaume Carteaux
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Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-10 Erik H A Michels,Brent Appelman,Justin de Brabander,Rombout B E van Amstel,Christine C A van Linge,Osoul Chouchane,Tom D Y Reijnders,Alex R Schuurman,Titia A L Sulzer,Augustijn M Klarenbeek,Renée A Douma,Lieuwe D J Bos,W Joost Wiersinga,Hessel Peters-Sengers,Tom van der Poll,
RATIONALE Lymphopenia in COVID-19 is associated with increased mortality. OBJECTIVES To explore the association between lymphopenia, host response aberrations and mortality in patients with lymphopenic COVID-19. METHODS We determined 43 plasma biomarkers reflective of four pathophysiological domains: endothelial cell and coagulation activation, inflammation and organ damage, and cytokine and chemokine
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Anticoagulation and Bleeding during Veno-Venous Extracorporeal Membrane Oxygenation: Insights from the PROTECMO Study. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-09 Gennaro Martucci,Marco Giani,Matthieu Schmidt,Kenichi Tanaka,Ali Tabatabai,Fabio Tuzzolino,Cara Agerstrand,Jordi Riera,Raj Ramanan,Giacomo Grasselli,Ali Ait Hssain,Whitney D Gannon,Sara Buabbas,Vojka Gorjup,Brian Trethowan,Monica Rizzo,Vito Fanelli,Kyeongman Jeon,Gennaro De Pascale,Alain Combes,Marco V Ranieri,Thibault Duburcq,Giuseppe Foti,Juan I Chico,Martin Balik,Lars Mikael Broman,Peter Schellongowski
RATIONALE Definitive guidelines for anticoagulation management during veno-venous extracorporeal membrane oxygenation (VV ECMO) are lacking, while bleeding complications continue to pose major challenges. OBJECTIVES To describe anticoagulation modalities and bleeding events in adults receiving VV ECMO. METHODS International prospective observational study in 41 centers, from December 2018 to February
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Reply to Gan et al., to Calzetta et al., and to Poor. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-08 Antonio Anzueto,Igor Z Barjaktarevic,Thomas M Siler,Tara Rheault,Thomas Bengtsson,Kathleen Rickard,Frank Sciurba
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Inhaled Dual PDE3/4 Inhibitor Ensifentrine for COPD: A Potential Therapeutic Perspective. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-08 Qiming Gan,Yanjuan Wu,Xiaofen Su,Jingcun Wang,Haojie Zhang,Nuofu Zhang,Kang Wu
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Pharmacological Interpretation of the Efficacy of Ensifentrine in COPD: Insights from ENHANCE Trials. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-08 Luigino Calzetta,Mario Cazzola,Paola Rogliani
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Implications of Mean Pulmonary Arterial Wedge Pressure Trajectories in Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. (IF 24.7) Pub Date : 2023-11-08 Eileen M Harder,Miguel J Divo,George R Washko,Jane A Leopold,Farbod N Rahaghi,Aaron B Waxman
RATIONALE The mean pulmonary arterial wedge pressure (mPAWP) is the critical hemodynamic factor differentiating Group 1 pulmonary arterial hypertension (PAH) from Group 2 pulmonary hypertension (PH) associated with left heart disease. Despite discrepancy between the mPAWP upper physiologic-normal and current PAH definition, the implications of the initial mPAWP for PAH clinical trajectory are poorly