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Tryptophan metabolism, exercise and depression Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-02-11 Brandon A. Yates
Depression is linked to an altered stress response, as measured by elevated levels of cortisol and systemic inflammation. Many individuals become resistant to pharmacological treatments; however, non-pharmacological treatments, such as increased physical activity and exercise training, can reduce symptoms of depression in some patients. A decade ago, a key paper helped to define the mechanisms that
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Recent advances in treatments for congenital adrenal hyperplasia Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-02-11 Henrik Falhammar, Svetlana Lajic, Anna Nordenström
The first CRFR1 antagonist (crinecerfont) to be used for the treatment of congenital adrenal hyperplasia recently received FDA approval. This Clinical Outlook discusses the latest phase III studies in children and adults, as well as how crinecerfont — in combination with glucocorticoid replacement — might change clinical practice and affect long-term co-morbidities.
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Hypoparathyroidism: diagnosis, management and emerging therapies Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-02-04 Sarah Khan, Aliya A. Khan
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Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-29 Olivia Tysoe
Physical exercise is well known to help to prevent obesity and to benefit cardiometabolic health. A new study in Nature Communications aimed to determine whether physical exercise could reverse cardiac dysfunction caused by a high-fat, high-calorie (HFHC) diet. “We originally wanted to observe a possible cardioprotective effect of physical exercise in HFHC-fed mice,” explains corresponding author Lang
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The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-16 Jasna Aleksova, Peter Ebeling, Grahame Elder
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Exploring the functions of the myokine feimin Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-15 Claire Greenhill
Skeletal muscle produces a range of myokines, which have various effects throughout the body. Two new studies published in Nature Metabolism have identified a myokine that they have termed feimin, and characterized its effects on glucose homeostasis and exercise performance. Using mice with whole-body knockout of the gene encoding feimin or one of various organ-specific knockout models (for example
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Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-09 Shintaro Iwama, Tomoko Kobayashi, Hiroshi Arima
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Metabolic effects of gender-affirming hormone therapy Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-08 Senegal Carty
As the field of gender-affirming hormone therapy (GAHT) evolves, research into how this type of treatment affects metabolism is needed to continually improve healthcare for transgender individuals. Twenty transgender men and 15 transgender women participated in the study. GAHT was administered independently of the study, so there was variation in the treatment regimens within each group. Before GAHT
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Illuminating the metabolic effects of circadian misalignment Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-06 Ioannis G. Lempesis
Circadian misalignment affects physiology and metabolism and increases the risk of developing cardiometabolic disease. A pivotal study by Frank Scheer’s team provided clear evidence that misaligned sleep–wake cycles and fasting–eating cycles impair glucose tolerance, insulin sensitivity and blood pressure, highlighting the importance of synchronizing lifestyles with our internal biological clocks.
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Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-06 Simon Lecoutre, Clémentine Rebière, Salwan Maqdasy, Mélanie Lambert, Sébastien Dussaud, Jimon Boniface Abatan, Isabelle Dugail, Emmanuel L. Gautier, Karine Clément, Geneviève Marcelin
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Bile acid metabolism in type 2 diabetes mellitus Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-06 Marti Cadena Sandoval, Rebecca A. Haeusler
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International consensus guidelines on the implementation and monitoring of vosoritide therapy in individuals with achondroplasia Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2025-01-06 Ravi Savarirayan, Julie Hoover-Fong, Keiichi Ozono, Philippe Backeljauw, Valérie Cormier-Daire, Kristen DeAndrade, Penny Ireland, Melita Irving, Juan Llerena Junior, Mohamad Maghnie, Margaret Menzel, Nadia Merchant, Klaus Mohnike, Susana Noval Iruretagoyena, Keita Okada, Svein Otto Fredwall
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Identification of genetic factors of type 2 diabetes mellitus risk in South Asian populations Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-17 Olivia Tysoe
People of South Asian ancestry are more likely to develop type 2 diabetes mellitus (T2DM) at a younger age and lower BMI than people of European ancestry. The reasons for this fact are poorly understood, as the majority of genetic research on T2DM has been performed in white European populations. Now, a study in Nature Medicine has used partitioned polygenic risk scores (pPS) to uncover the genetic
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From the perspective of a scientist with Cushing disease, what did not kill me made my science stronger Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-17 Yana Zavros
Research siloes slow the translation of scientific discovery to patient care and limit progress in improving treatments for Cushing disease to incremental advances. Facilitating collaborative efforts that study the complexity of pituitary neuroendocrine tumours would advance the development of targeted treatments for patients who experience a low quality of life for years owing to this rare and understudied
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Publisher Correction: Growth hormone-releasing hormone and its analogues in health and disease Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-16 Riccarda Granata, Sheila Leone, Xianyang Zhang, Iacopo Gesmundo, Charlotte Steenblock, Renzhi Cai, Wei Sha, Ezio Ghigo, Joshua M. Hare, Stefan R. Bornstein, Andrew V. Schally
Correction to: Nature Reviews Endocrinology https://doi.org/10.1038/s41574-024-01052-1, published online 13 November 2024.
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Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-13 Valter D. Longo
Several new clinical studies provide evidence for the potential of specific intermittent and periodic fasting interventions to decrease adiposity and HbA1c in patients with obesity and/or type 2 diabetes mellitus, while also reducing drug use, adverse effects and risk factors for other diseases.
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Advances in appetite regulation by the arcuate nucleus Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-13 Cristina Garcia-Caceres
In 2024, new insights identified a cluster of leptin-targeted neurons and integrative networks that link sensory inputs (heat and food perception) with feeding centres and peripheral systems. Key findings revealed hypothalamic site-specific adaptive mechanisms, in which nutritional state-dependent remodelling of extracellular compounds and neuropeptide transmission calibrate appetite via the arcuate
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Surveying the landscape of emerging osteoanabolic therapies Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-09 Thomas H. Ambrosi
Established antiresorptive treatments for osteoporosis only slow down bone loss, and available osteoanabolic therapies — although more effective — have broad limitations. Recent insights into sex-specific systemic regulation of skeletal mass, an enhanced understanding of the cellular complexity of bone marrow and innovative options such as senolytics have fuelled the development of potentially transformative
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Advances in basic biology and translation in islet research Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-04 Carmella Evans-Molina
Advances in islet cell biology over the past few years highlight a fundamental role for intra-islet endocrine cell interactions and δ-cells in the regulation of glycaemia. New insights into how cellular heterogeneity and individual-level heterogeneity effect hormone secretion have also emerged.
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Advances in cardiometabolic outcomes in polycystic ovary syndrome Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-04 Lisa J. Moran
The year 2024 brought continuing research in the crucial field of adiposity-related health and polycystic ovary syndrome (PCOS). Although PCOS is considered a heterogeneous condition with regards to diagnostic criteria, complications and management, current research is advancing our understanding of the presentation and metabolic features of PCOS, as well as the benefits of lifestyle management.
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Memory of obesity stored in adipocytes Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-12-03 Claire Greenhill
In humans, weight loss as a result of lifestyle interventions, pharmacotherapy or bariatric surgery is often followed by weight regain. It is thought that cells retain an obesogenic memory that predisposes the body to return to the previous level of adiposity; however, the mechanisms that underlie this effect have been unclear. A new study has now demonstrated that adipocytes in humans and mice retain
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Opposing neuropeptides control cAMP signalling to regulate satiety Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-29 Senegal Carty
It is well known that neuropeptides have a key role in regulating feeding behaviour. However, many aspects of the mechanisms behind neuropeptide control of satiety and hunger are unclear. A recent study in mice demonstrates that two neuropeptides, neuropeptide Y and αMSH, exert opposing effects on cAMP signalling in MC4R-expressing neurons in the paraventricular nucleus of the hypothalamus (PVHMC4R
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Consensus on the key characteristics of metabolism disruptors Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-29 Michele A. La Merrill, Martyn T. Smith, Cliona M. McHale, Jerrold J. Heindel, Ella Atlas, Matthew C. Cave, David Collier, Kathryn Z. Guyton, Suneil Koliwad, Angel Nadal, Christopher J. Rhodes, Robert M. Sargis, Lauren Zeise, Bruce Blumberg
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Polycystic ovary syndrome as a metabolic disease Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-28 Nafiye Helvaci, Bulent Okan Yildiz
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Author Correction: Growth hormone-releasing hormone and its analogues in health and disease Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-28 Riccarda Granata, Sheila Leone, Xianyang Zhang, Iacopo Gesmundo, Charlotte Steenblock, Renzhi Cai, Wei Sha, Ezio Ghigo, Joshua M. Hare, Stefan R. Bornstein, Andrew V. Schally
Correction to: Nature Reviews Endocrinology https://doi.org/10.1038/s41574-024-01052-1, published online 13 November 2024.
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Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-27 Kirstin MacGregor, Stian Ellefsen, Nicolas J. Pillon, Daniel Hammarström, Anna Krook
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Leveraging research into sex differences and steroid hormones to improve brain health Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-25 Bonnie H. Lee, Rand S. Eid, Travis E. Hodges, Claudia Barth, Liisa A. M. Galea
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Expanding applications of therapies based on GLP1 Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-21 Daniel J. Drucker
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Growth hormone-releasing hormone and its analogues in health and disease Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-13 Riccarda Granata, Sheila Leone, Xianyang Zhang, Iacopo Gesmundo, Charlotte Steenblock, Renzhi Cai, Wei Sha, Ezio Ghigo, Joshua M. Hare, Stefan R. Bornstein, Andrew V. Schally
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Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus? Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-11 A. M. James Shapiro
A patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 year after transplantation of autologous stem cell islets. These cells were differentiated from inducible pluripotent stem cells from adipose tissue and were transplanted into the rectus sheath of the abdominal wall.
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Macrophages support pancreatic development Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-08 Senegal Carty
Engineering pancreatic tissue transplants to treat diabetes mellitus will require knowledge of how different cell types regulate pancreatic development. A study in Cell Stem Cell characterizes the nuclear transcriptome in the second-trimester human fetal pancreas and shows that macrophages support pancreatic endocrine cell differentiation, proliferation and survival in vitro. To investigate whether
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Highlights from the Joint Irish–UK Endocrine Meeting 2024 Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-08 Olivia Tysoe
This October, the first joint meeting between the Irish Endocrine Society (IES) and the British Society for Endocrinology (SfE) was held in Belfast. On the opening morning, Miguel Debono (University of Sheffield) spoke to a packed room about the challenges of managing mild autonomous cortisol secretion. He discussed whether conservative management or adrenalectomy provided the best outcome for patients
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IL-17 has a role in whole-body homeostasis Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-08 Claire Greenhill
The immune system is known to have a circadian rhythm; however, how circadian rhythms might affect immune homeostasis and physiology more broadly is unclear. A new paper now provides evidence that γδ T cells (a type of innate T cell) produce IL-17 in a rhythmic fashion, which is essential for de novo lipogenesis in adipose tissue and influences whole-body homeostasis. To confirm that IL-17A and IL-17F
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Intricacies and obscurities of non-shivering thermogenesis Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-05 Anand Kumar Sharma
Mammalian cellular machinery has evolved to function best at ~37 °C, making maintenance of core body temperature (at ~37 °C) critical for optimal organ function. The physiological importance of thermoregulation has been appreciated for many years, but our mechanistic understanding of the diversity and functioning of thermogenic mechanisms has advanced considerably in the past century. A brief analysis
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Looking back at the TEDDY study: lessons and future directions Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-11-04 Åke Lernmark, Daniel Agardh, Beena Akolkar, Patricia Gesualdo, William A. Hagopian, Michael J. Haller, Heikki Hyöty, Suzanne Bennett Johnson, Helena Elding Larsson, Edwin Liu, Kristian F. Lynch, Eoin F. McKinney, Richard McIndoe, Jessica Melin, Jill M. Norris, Marian Rewers, Stephen S. Rich, Jorma Toppari, Eric Triplett, Kendra Vehik, Suvi M. Virtanen, Anette-G. Ziegler, Desmond A. Schatz, Jeffrey
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Our future, we decide: five ways to reform the scientific publication process Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-28 Morten Dall, Katharina Herzog, Antonia Hufnagel, Daniel B. Ibsen, Benjamin Lebiecka-Johansen, Philip M. M. Ruppert, Jessica M. Preston, Pearlyn J. Y. Toh, Christina Yfanti
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Metformin in gestational diabetes: physiological actions and clinical applications Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-25 Taitum Mason, Simon Alesi, Melinda Fernando, Eszter Vanky, Helena J. Teede, Aya Mousa
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Limiting the use and misuse of liothyronine in hypothyroidism Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-24 Laszlo Hegedüs, Endre Vezekenyi Nagy, Enrico Papini, Petros Perros
Liothyronine treatment for some patients with hypothyroidism has preoccupied academics, clinicians and patients for decades, and is a controversial topic in thyroidology. Persistent symptoms are at the heart of this discourse and, contrary to scientific evidence, liothyronine use is increasingly common. Aetiologies and interventions beyond thyroid dysregulation and pharmacological approaches must be
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Modelling human liver disease: from steatotic liver disease to MASH-HCC Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-24 Christian Stoess, Ariel E. Feldstein
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Publisher Correction: Current understanding of the molecular and cellular pathology of diabetic retinopathy Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-24 David A. Antonetti, Paolo S. Silva, Alan W. Stitt
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The epidemiology of type 1 diabetes mellitus in older adults Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-24 Dunya Tomic, Jessica L. Harding, Alicia J. Jenkins, Jonathan E. Shaw, Dianna J. Magliano
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Inflammation and resolution in obesity Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-24 Matúš Soták, Madison Clark, Bianca E. Suur, Emma Börgeson
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The complex effects of dietary restriction on longevity and health Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-22 Claire Greenhill
Calorie restriction is known to extend lifespan in a wide range of species; however, the effects are variable and findings from animal models are often not applicable to humans, as the calorie restriction regimes are generally difficult to adhere to in the real world. Now, a paper has explored the effects and underlying mechanisms of several different methods of calorie restriction and dietary restriction
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IGF2-produced microRNA restricts growth via suppression of IGF1 Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-15 Olivia Tysoe
Insulin-like growth factor 1 (IGF1) is a key protein that contributes to control of an organism’s size after birth and during development, whereas IGF2 is the main regulator of growth and body size during fetal development. A study in Cell Reports describes a mechanism by which a microRNA produced from Igf2 regulates IGF1 to suppress growth in mice. The researchers then assessed the effect of miR-483
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Skeletal stem and progenitor cells in bone physiology, ageing and disease Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-08 Seppe Melis, Dana Trompet, Andrei S. Chagin, Christa Maes
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Signals from the dorsal motor nucleus of the vagus promote jejunal fat absorption Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-10-08 Senegal Carty
Efferent nerves from the dorsal motor nucleus of the vagus (DMV) connect to the gastrointestinal system and are thought to regulate digestion. The mechanisms by which the DMV controls nutrient absorption are under active investigation. A study published in Nature shows that a subpopulation of DMV neurons controls intestinal dietary fat absorption by modulating microvillus length in the jejunum. The
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Liver-specific actions of GH and IGF1 that protect against MASLD Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-25 Rhonda D. Kineman, Mercedes del Rio-Moreno, David J. Waxman
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Control of tuberal hypothalamic development and its implications in metabolic disorders Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-23 Marysia Placzek, Kavitha Chinnaiya, Dong Won Kim, Seth Blackshaw
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The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-23 Joanne Lysaght, Melissa J. Conroy
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Early life factors that affect obesity and the need for complex solutions Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-23 Kylie D. Hesketh, Miaobing Zheng, Karen J. Campbell
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Brown adipose tissue fights the battle against leukaemia Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-20 Pamela Fischer-Posovszky, Julia Zinngrebe
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The glymphatic system as a nexus between obesity and neurological diseases Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-20 Bandy Chen, Stephanie Lenck, Jean-Leon Thomas, Marc Schneeberger
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Effects of diet on atherosclerotic plaque development Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-19 Claire Greenhill
Atherosclerosis-related cardiovascular diseases are a major cause of death globally, and are expected to increase in prevalence with the rising incidence of obesity and type 2 diabetes mellitus. Despite being very common, there are still large knowledge gaps in our understanding of how atherosclerosis develops. Furthermore, most animal models for atherosclerosis rely on the use of a continuous high-fat
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Female-specific inflammatory signalling exacerbates central nervous system autoimmunity in obesity Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-19 Olivia Tysoe
Multiple sclerosis (MS) targets the myelin sheath of central nervous system (CNS) neurons. MS is initiated by autoreactive CD4+ T cells, and obesity is known be associated with an increased risk of MS, particularly in women. A study in Cell Metabolism now identifies a female-specific mechanism by which obesity increases the risk of MS by promoting a pro-inflammatory T helper 1 (TH1) CD4+ T cell phenotype
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Skeletal muscle loss and sarcopenia in obesity pharmacotherapy Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-18 David C. D. Hope, Tricia M-M Tan
Pharmacological therapies with incretin-based ‘multi-agonists’ are rapidly advancing the therapeutic landscape for obesity. The loss of skeletal muscle mass with these potent weight-loss agents is emerging as a possible side effect. It is therefore important to determine whether multi-agonists increase the risk of sarcopenia in susceptible patients.
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The role of DNA damage in diabetic complications Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-12 Varun Kumar, Ali Önder Yildirim, Peter P. Nawroth
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Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-09-03 Alessandro Grattoni, Gregory Korbutt, Alice A. Tomei, Andrés J. García, Andrew R. Pepper, Cherie Stabler, Michael Brehm, Klearchos Papas, Antonio Citro, Haval Shirwan, Jeffrey R. Millman, Juan Melero-Martin, Melanie Graham, Michael Sefton, Minglin Ma, Norma Kenyon, Omid Veiseh, Tejal A. Desai, M. Cristina Nostro, Marjana Marinac, Megan Sykes, Holger A. Russ, Jon Odorico, Qizhi Tang, Camillo Ricordi
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Neurons in the diagonal band of Broca moderate food intake Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-08-29 Senegal Carty
Identifying neurological mechanisms that regulate feeding behaviour could help to advance the treatment and prevention of obesity and eating disorders. New research in mice has identified and localized a population of neurons that promotes eating to satiate hunger and reduces the desire to eat simply for pleasure. One subset of these DBBPENK neurons projects from the DBB to the paraventricular nucleus
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The promising potential of gene therapy for diabetes mellitus Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-08-29 Stefan R. Bornstein, J. Fraser Wright, Charlotte Steenblock
Gene therapy holds tremendous promise for treating a wide range of hereditary and acquired diseases by delivering exogenous therapeutic nucleotide sequences into specific cells or tissues. Recent advances support the notion that gene therapy could offer a long-term cure for diabetes mellitus, something that current conventional pharmacotherapies cannot achieve.
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Author Correction: International consensus statement on the diagnosis and management of phaeochromocytoma and paraganglioma in children and adolescents Nat. Rev. Endocrinol. (IF 31.0) Pub Date : 2024-08-27 Ruth T. Casey, Emile Hendriks, Cheri Deal, Steven G. Waguespack, Verena Wiegering, Antje Redlich, Scott Akker, Rathi Prasad, Martin Fassnacht, Roderick Clifton-Bligh, Laurence Amar, Stefan Bornstein, Letizia Canu, Evangelia Charmandari, Alexandra Chrisoulidou, Maria Currás Freixes, Ronald de Krijger, Luisa de Sanctis, Antonio Fojo, Amol J. Ghia, Angela Huebner, Vasilis Kosmoliaptsis, Michaela Kuhlen
Correction to: Nature Reviews Endocrinology https://doi.org/10.1038/s41574-024-01024-5, published online 15 August 2024.