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We thank Dr. Arora et al for their letter1 in response to our systematic review on scores used to predict outcomes in acute severe ulcerative colitis (ASUC), and appreciate the additional information regarding their excellent work in developing and validating the AIIMS index.2-4 We agree the Lichtiger index is a valuable tool for the diagnosis of ASUC and assessment of steroid failure. However, since

Editors, We thank Dr. Con et al for their interest in our study and their insightful comments.1, 2 We would like to address their points and provide additional context to our findings. As a potential explanation for the inferior long-term effectiveness of infliximab in our study, Con et al propose an immunological secondary loss of efficacy due to antibody formation. We acknowledge this as an important

Dr. Kayal and colleagues are to be congratulated on their efforts to summarise systematically the existing literature on prognostic scoring in acute severe ulcerative colitis (ASUC) while also addressing their inherent limitations.1 First, we would like to highlight a discrepancy in the bibliography namely our centre's publication introducing the AIIMS index for predicting steroid failure (Ref 20)

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