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Navigating the Landscape of Translational Geroscience in Canada: A Comprehensive Evaluation of Current Progress and Future Directions J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-15 Guy Hajj-Boutros, Andréa Faust, John Muscedere, Perry Kim, Naji Abumrad, Stéphanie Chevalier, Mylene Aubertin-Leheudre, Howard Bergman, Dawn Bowdish, Jessica Burford, Stacy Carrington-Lawrence, Hélène Côté, David E Dawe, Philipe de Souto Barreto, Colin Farrelly, Robert Fowler, Gilles Gouspillou, Lea Harrington, Sofie Lautrup, Susan Howlett, Mahdi Imani, James Kirkland, George Kuchel, Frédérick A Mallette
The inaugural Canadian Conferences on Translational Geroscience were held as two complementary sessions in October and November 2023. The conferences explored the profound interplay between the biology of aging, social determinants of health, the potential societal impact of geroscience and the maintenance of health in aging individuals. Although topics such as cellular senescence, molecular and genetic
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Increased Risk of New-Onset Parkinson’s Disease Following a Diagnosis of Retinal Vascular Occlusion: A 14-year Cohort Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Seung Hoon Kim, Minah Park, Sung Hoon Jeong
Background Although the role of the vascular component in the pathophysiology of Parkinson’s disease is widely accepted and retinal vascular abnormalities are commonly observed in Parkinson’s disease patients, evidence connecting retinal vascular disorders with the risk of developing Parkinson’s disease is limited. We aimed to investigate the association between retinal vascular occlusion and the risk
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Loneliness, living alone and risk of cardiovascular disease among older adults in China J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Siyue Tan, Dong Liu, Yuyi Zhang, Shengnan Li, Ke Zhang, Zaixiang Tang, Hui Zuo
Background Older adults are prone to live alone and feel lonely. The main objective of this study was to assess the associations of loneliness and living alone with cardiovascular disease (CVD) among community-dwelling older individuals in China. Methods We conducted a longitudinal analysis on 3661 participants aged over 65 years from the latest 2014 and 2018 waves of the Chinese Longitudinal Healthy
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Pain characteristics and progression to sarcopenia in Chinese middle-aged and older adults: a 4-year longitudinal study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-12 Jintao Chen, Liying Yan, Jingjing Chu, Xinyi Wang, Zherong Xu
Background It is imperative for public health to identify the factors that contribute to the progression of sarcopenia among middle-aged and older adults. Our study aimed to investigate the association between pain characteristics and the progression to sarcopenia and its subcomponents among middle-aged and older adults in China. Methods We included 5568 participants from the China Health and Retirement
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Lack of Immune-resilience negatively affects Physical-resilience. Results from the InCHIANTI follow-up study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Raffaello Pellegrino, Roberto Paganelli, Angelo Di Iorio, Stefania Bandinelli, Chiara Mussi, Eleonora Sparvieri, Stefano Volpato, Toshiko Tanaka, Luigi Ferrucci
There is consistent evidence that immune response declines with aging, with wide inter-individual variability and a still unclear relationship with the development of frailty. To address this question we assessed the role of immune resilience (capacity to restore immune functions), operationalized as the neutrophil-to-lymphocytes ratio (NL-ratio) and monocytes-to-lymphocytes ratio (ML-ratio), in the
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Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Päivi Herranen, Kaisa Koivunen, Teemu Palviainen, Urho M Kujala, Samuli Ripatti, Jaakko Kaprio, Elina Sillanpää
Background We used a polygenic score for hand grip strength (PGS HGS) to investigate whether genetic predisposition for higher muscle strength predicts age-related noncommunicable diseases, survival from acute adverse health events, and mortality. Methods This study consisted of 342 443 Finnish biobank participants from FinnGen Data Freeze 10 (53% women) aged 40 to 108 with combined genotype and health
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Effects of Multicomponent Home-Based Intervention on Muscle Composition, Fitness and Bone Density after Hip Fracture J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Alice S Ryan, Brock A Beamer, Ann L Gruber-Baldini, Rebecca L Craik, Justine Golden, Jack Guralnik, Marc C Hochberg, Kathleen K Mangione, Denise Orwig, Alan M Rathbun, Jay Magaziner
Background Mechanistic factors on the pathway to improving independent ambulatory ability among hip fracture patients by a multicomponent home-based physical therapy intervention that emphasized aerobic, strength, balance, and functional training are unknown. The aim of this study was to determine the effects of two different home-based physical therapy programs on muscle area and attenuation (reflects
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Association of combined healthy lifestyle factors with incident dementia in participants with and without multimorbidity: a large population-based prospective cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-07 Ying-ying Niu, Jian-feng Zhong, Hui-yan Wen, Hao-yu Yan, Zhi-quan Diao, Jia-xin Li, Xue-rui Bai, Jia-min Qiu, Zhi-tong Xu, Lian-hong Chen, Cheng-ping Li, Jing Li, Xiao-feng Liang, Dan Liu
BACKGROUND The effect of a healthy lifestyle on dementia associated with multimorbidity-related is not well-understood. Our objective is to examine whether the adoption of a healthy lifestyle could potentially reduce the elevated risk of dementia in individuals with and without multimorbidity. METHODS We utilized data from the UK Biobank cohort. A comprehensive healthy lifestyle score, ranging from
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Association between serum NT-proBNP and gray matter atrophy patterns in an older Japanese population: the Hisayama Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-06 Naoki Hirabayashi, Jun Hata, Yoshihiko Furuta, Taro Nakazawa, Tomoyuki Ohara, Mao Shibata, Fumio Yamashita, Takanari Kitazono, Nobuyuki Sudo, Toshiharu Ninomiya
Several population-based studies have reported that higher serum N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are associated with brain morphological changes. However, no population-based studies have examined the relationship between serum NT-proBNP and various regional brain volumes in detail. We here analyzed the brain MRI data of 1,201 community-dwelling Japanese aged ≥65 years.
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Circular RNA circVmn2r1 acts as a miR-223-3p sponge to promote kidney aging by regulating NLRP3 expression in mice J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-06 Fanfan Gao, Limin Wei, Jie Li, Lu Zeng, Meng Wang, Ping Lan, Shanshan Liang, Xinmei Huang, Lei Chen, Hongli Jiang
Kidney aging accelerates the progression of various acute and chronic kidney diseases and can also induce pathological changes in other organs throughout the body. Circular RNAs (circRNAs), have been demonstrated to play a vital role in aging and age-related diseases. However, biological functions and the underlying molecular mechanism of circRNAs in kidney aging remain largely unclear. Uncovering
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Predictors of urinary and faecal incontinence in pre-frail and frail older adults: a cross-sectional study of the FRAGSALUD project J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-04 Juan Corral-Pérez, Laura Ávila-Cabeza-de-Vaca, Inmaculada Valero-Cantero, Andrea González-Mariscal, Jesús G Ponce-González, María Ángeles Vázquez-Sánchez, Cristina Casals
Background Frailty is associated with urinary and faecal incontinence, which are common geriatric syndromes. This study aims to identify health factors associated with incontinence in pre-frail or frail older adults living in the community. Methods This multicentre cross-sectional study included 225 older adults (75.0±6.4 years) with pre-frailty or frailty based on the five-component Fried phenotype
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Chewing disability is associated with cognitive impairment among older adults: a population-based cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-02 Gustavo G Nascimento, Huihua Li, Rahul Malhotra, Fábio R M Leite, Karen G Peres, Angelique Chan, Marco A Peres
Background Chewing disability is associated with impaired quality of life, potentially leading to depression and cognitive impairment. While the chewing-ability-cognition relationship has been explored, examining whether depression mediates this relationship remains unclear. We investigated the association between chewing disability and cognitive impairment development and a potential mediation via
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The Impact of Type 2 Diabetes on Peripheral and Cerebral Haemodynamic Responses to Active Stand J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-03-01 Belinda Hernández, Adam H Dyer, Ciaran Finucane, Bernardo Nipoti, Roman Romero-Ortuno, Richard Reilly, Rose Anne Kenny
Background Whilst Type 2 Diabetes Mellitus (T2DM) is an established risk factor for cognitive impairment, the underlying mechanisms remain poorly explored. One potential mechanism may be through effects of T2DM on cerebral perfusion. The current study hypothesised that T2DM is associated with altered peripheral and central haemodynamic responses to orthostasis, which may in turn be associated with
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Young Plasma Rejuvenates Blood Dna Methylation Profile, Extends Mean Lifespan And Improves Physical Appearance In Old Rats J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-29 Priscila Chiavellini, Marianne Lehmann, Maria D Gallardo, Martina Canatelli Mallat, Diana C Pasquini, Joseph A Zoller, Juozas Gordevicius, Mauricio Girard, Ezequiel Lacunza, Claudia B Herenu, Steve Horvath, Rodolfo G Goya
There is converging evidence that young blood conveys cells, vesicles and molecules able to revitalize function and restore organ integrity in old individuals. We assessed the effects of young plasma on the lifespan, epigenetic age and healthspan of old female rats. Beginning at 25.6 months of age, a group of 9 rats (group T) was i.p. injected with plasma from young rats until their natural death.
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Life history trade-offs in Drosophila: flies select a diet to maximize reproduction at the expense of lifespan J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-29 Olha Strilbytska, Uliana Semaniuk, Dmytro Gospodaryov, Stephen J Simpson, Oleh Lushchak
Macronutrient intake impacts physiology, behavior, physiology and gene expression in a wide range of organisms. We used the response surface methodology to compare how life history traits, lifespan and reproduction differ as a function of protein and carbohydrate intakes under choice and no-choice feeding regimens in the fruit fly, Drosophila melanogaster. We found that when offered a choice of nutritionally
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Age is Associated with Dampened Circadian Patterns of Rest and Activity: The Study of Muscle, Mobility and Aging (SOMMA) J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-28 Melissa L Erickson, Terri L Blackwell, Theresa Mau, Peggy M Cawthon, Nancy W Glynn, Yujia (Susanna) Qiao, Steven R Cummings, Paul M Coen, Nancy E Lane, Stephen B Kritchevsky, Anne B Newman, Samaneh Farsijani, Karyn A Esser
Background The effects of aging on circadian patterns of behavior are insufficiently described. To address this, we characterized age-specific features of rest-activity rhythms (RAR) in community dwelling older adults both overall, and in relation, to sociodemographic characteristics. Methods We examined cross-sectional associations between RAR and age, sex, race, education, multimorbidity burden,
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Genome-wide search links senescence-associated secretory proteins with susceptibility for coronary artery disease in mouse and human J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-28 Yuan-Zheng Zhu, Jian-Kun Liu, Xue-Er Li, Zhen-Ping Yu, Lu-Qin Yang, Qin Wan, Ya Zhao, Muhammad Saeed, An-Dong Wu, Xiao-Li Tian
Advanced age is an independent risk factor for coronary artery disease (CAD), the leading global cause of mortality. Senescent vascular cells in the atherosclerotic plaques exhibit senescence-associated secretory phenotype (SASP). How SASP contributes to atherosclerosis and CAD, however, remains unclear. Here we integrated RNA-array datasets of senescent human coronary arterial endothelial cells (HCAECs)
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LncRNA Gm15232 Promotes Lipogenesis in Aging Mice Through the miR-192-3p/GCR Pathway J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-27 Yaqi Hu, Yifan Zhang, Shuwen Wang, Rui Wang, Qi Yuan, Wei Wu, Yibei Gui, Jiale Zhao, Xueqing Li, Yumin He, Chengfu Yuan
Recent scientific studies have highlighted the importance of long chain non-coding RNAs (lncRNAs) in a variety of metabolic diseases, but the specific functions and mechanisms of lncRNAs in aberrant lipid synthesis associated with aging are unknown. In this work, we inspected the effects of lncRNAs on the lipid metabolism in aging mice, as substantial evidence suggests that aging disturbs lipid metabolism
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Postural control characteristics in Alzheimer’s disease, dementia with Lewy bodies, and vascular dementia J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-27 Kosuke Fujita, Taiki Sugimoto, Hisashi Noma, Yujiro Kuroda, Nanae Matsumoto, Kazuaki Uchida, Yoshinobu Kishino, Takashi Sakurai
Background Dementia often results in postural control impairment, which could signify central nervous system dysfunction. However, no studies have compared postural control characteristics among various types of dementia. This study aimed to compare static postural control in patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia (VaD). Methods Cross-sectional
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DHCR24 insufficiency promotes vascular endothelial cell senescence and endothelial dysfunction via inhibition of Caveolin-1/ERK signaling J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-25 Han Li, Zhen Yang, Wukaiyang Liang, Hao Nie, Yuqi Guan, Ni Yang, Tianyi Ji, Yu Liu, Yi Huang, Le Zhang, Jinhua Yan, Cuntai Zhang
Endothelial cells (ECs) senescence is critical for vascular dysfunction, which leads to age-related disease. DHCR24, a 3β-hydroxysterol δ 24 reductase with multiple functions other than enzymatic activity, has been involved in age-related disease. However, little is known about the relationship between DHCR24 and vascular ECs senescence. We revealed that DHCR24 expression is chronologically decreased
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Longitudinal quantiles of frailty trajectories considering death: new insights into sex and cohort differences in the reference curves for frailty progression of older European J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-23 Alejandra Marroig, Fernando Massa, Annie Robitaille, Scott M Hofer, Erwin Stolz, Graciela Muniz-Terrera
Background Most previous studies of frailty trajectories in older adults focus on the average trajectory and ignore death. Longitudinal quantile analysis of frailty trajectories permits the definition of reference curves, and the application of mortal cohort inference provides more realistic estimates than models that ignore death. Methods Using data from individuals aged 65 or older (n=25446) from
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Non-coding RNA contribution to aging and lifespan J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-23 Alejandro Piñeiro Ugalde, David Roiz del Valle, Lucas Moledo Nodar, Xurde Menéndez Caravia, José María Pérez Freije, Carlos López Otín
Aging is a multifactorial process characterized by an age-related decline in organismal fitness. This deterioration is the major risk factor for chronic diseases such as cardiovascular pathologies, neurodegeneration or cancer, and it represents one of the main challenges of modern society. Therefore, understanding why and how we age would be a fundamental pillar to design strategies to promote a healthy
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The complexity of center of pressure positions during quiet stance and its relationship to cognition, aging and falls J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-23 Antoine Langeard, Emma Milot, Gaëlle Quarck, Thomas Stoffregen
BACKGROUND In a secondary analysis of data taken from a publicly available database, we examined cognitive performance, postural sway, and relations between them for four groups: younger and older individuals with versus without a recent history of falls. Our objective was to compare linear versus nonlinear measures of postural activity as post-hoc predictors of cognitive performance and falling. METHODS
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Association of testosterone and sex hormone-binding globulin with all-cause and cardiovascular disease mortality in older Chinese men J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-23 Mei Jiao Li, Chao Qiang Jiang, Ya Li Jin, Tong Zhu, Feng Zhu, Wei Sen Zhang, Lin Xu
Background The associations of high and low testosterone with all-cause and cardiovascular disease (CVD) mortality risk in men are conflicting. Our objective was to examine associations of total testosterone, free testosterone, bioavailable testosterone, and sex hormone-binding globulin (SHBG) with all-cause and CVD mortality in older Chinese men. Methods Total testosterone and SHBG were assayed, and
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Predictors of frailty transitions in Mexican older adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-22 Ana Rivera-Almaraz, Aarón Salinas-Rodríguez, Eduardo Gutiérrez-Peña, Betty Soledad Manrique-Espinoza
Background Frailty is a dynamic state in older adults. Current evidence, mostly in high-income countries, found that improving frailty is more likely in mild states (prefrailty). We aimed to determine the probability of frailty transitions and their predictors. Methods Participants were adults aged 50 years or over from the Study on Global Ageing and Adult Health in Mexico during 4 waves (2009, 2014
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White Matter Plasticity Underpins Cognitive Gains after Multidomain Adaptive Computerized Cognitive Training J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-22 Xiangwei Dai, Sihan Liu, Yumeng Li, Shijie Long, Xin Li, Chuansheng Chen, Caishui Yang, Junying Zhang, Zhuo Rachel Han, He Li, Jun Wang, Zhanjun Zhang
Background This study aims to evaluate the effectiveness of computerized cognitive training (CCT) on white matter (WM) neuroplasticity and neuropsychological performance. Methods A total of 128 community older adults (64.36 ± 6.14 years) were recruited and randomly assigned to the intervention or the control group. Participants in the intervention group received a home-based, multidomain, and adaptive
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Abdominal body composition reference ranges and association with chronic conditions in an age- and sex-stratified representative sample of a geographically defined American population J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-19 Alexander D Weston, Brandon R Grossardt, Hillary W Garner, Timothy L Kline, Alanna M Chamberlain, Alina M Allen, Bradley J Erickson, Walter A Rocca, Andrew D Rule, Jennifer L St. Sauver
Background Body composition can be accurately quantified from abdominal CT exams and is a predictor for the development of aging-related conditions and for mortality. However, reference ranges for CT-derived body composition measures of obesity, sarcopenia, and bone loss have yet to be defined in the general population. Methods We identified a population-representative sample of 4,900 persons aged
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The Impact of Air Pollution on Physical Functioning Decline and the Benefits of Greenness: Evidence from a Nationwide Cohort Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-19 Ke Zhang, Jie He, Zhongyang Chen, Mengnan Pan, Jiahui Tong, Dejian Kou, Feifei Liu, Hao Xiang
Background Physical functional limitations (PFLs) increase the vulnerability of adults, but their pathogenesis remains unclear. Methods We conducted a nationwide longitudinal study on 62,749 records from 18,878 adults (aged ≥45) from 28 provinces in China. Risk of PFLs was assessed using a validated 9-item questionnaire. Exposure levels of air pollutants (PM10, PM2.5, and PM1) and greenness (Normalized
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Metabolome-wide Mendelian Randomization Assessing the Causal Relationship between Blood Metabolites and Sarcopenia-related Traits J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-17 Simin Chen, Yiran Dong, Nuerbiyamu Aiheti, Jie Wang, Shikang Yan, Kaidiriyan Kuribanjiang, Huilong Li, Xing Peng, Abudunaibi Wupuer, Yihan Li, Lei Yang, Jianping Zhao
Sarcopenia is among the most common musculoskeletal illnesses, yet its underlying biochemical mechanisms remain incompletely understood. In this study, we used Mendelian randomization (MR) to investigate the causal relationship between the genetically determined blood metabolites and sarcopenia, with the overall objective of identifying likely molecular pathways for sarcopenia. We used two-sample MR
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Cacao Procyanidins-Induced Lifespan Extension in Caenorhabditis elegans in a Nervous System and CaMKII Dependent Manner J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-17 Keiya Ohmine, Yuki Morinaga, Sarina Kobayashi, Aika Matsubara, Kaito Sadanaga, Shuhei Tohtani, Hideaki Saeki, Hiroto Horiuchi, Yuta Fujikawa, Koichiro Sumi, Midori Natsume, Hideshi Inoue
Procyanidins are gaining attention due to their potential health benefits. We found that cacao liquor procyanidin (CLPr) from Theobroma cacao seeds increased the lifespan of Caenorhabditis elegans, a representative model organism for aging studies. The genetic dependence of the lifespan-extending effect of CLPr was consistent with that of blueberry procyanidin, which is dependent on unc-43, osr-1,
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Associations between D3Cr muscle mass and MR thigh muscle volume with strength, power, physical performance, fitness, and limitations in older adults in the SOMMA study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-17 Peggy M Cawthon, Terri L Blackwell, Stephen B Kritchevsky, Anne B Newman, Russell T Hepple, Paul M Coen, Bret H Goodpaster, Kate Duchowny, Megan Hetherington-Rauth, Theresa Mau, Mahalakshmi Shankaran, Marc Hellerstein, William J Evans, Steven R Cummings
Background How magnetic resonance (MR) derived thigh muscle volume and d3-creatine dilution derived muscle mass (D3Cr muscle mass) differentially relate to strength, fitness, and other functional in older adults - and whether associations vary by sex - is not known. Methods Men (N=345) and women (N=482) aged ≥70 years from the Study of Muscle, Mobility and Aging completed leg extension strength (1-repetition
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Skeletal muscle ageing: lessons from teleosts J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-16 Tuyen K Quach, Megan F Taylor, Peter D Currie, Nir Eynon, Avnika A Ruparelia
Ageing is the greatest risk factor for a multitude of age-related diseases including sarcopenia -the loss of skeletal muscle mass and strength - which occurs at remarkable rates each year. There is an unmet need not only to understand the mechanisms that drive sarcopenia, but also to identify novel therapeutic strategies. Given the ease and affordability of husbandry, along with advances in genomics
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Effect of gut microbiota-mediated tryptophan metabolism on inflammaging in frailty and sarcopenia J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-16 Yu Shuang Xu, Tao Mao, You Jun Wang, Xing Si Qi, Wen Jun Zhao, Hao Chen, Cui Ping Zhang, Xiao Yu Li
Frailty syndrome refers to the nonspecific state of increased body vulnerability and decreased antistress and recovery abilities after stress during aging. Sarcopenia is the major component of frailty and is characterized by the gradual loss of muscle mass, strength, and function with age. Inflammaging is the gradual increase in inflammatory status during aging, and it disrupts immune tolerance, causes
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“Cognitive” Criteria in Older Adults with Slow Gait Speed: Implications for Motoric Cognitive Risk Syndrome J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-13 Caroline O Nester, Qi Gao, Cuiling Wang, Mindy J Katz, Richard B Lipton, Joe Verghese, Laura A Rabin
Background Motoric Cognitive Risk Syndrome (MCR) is a predementia condition that combines slow gait speed and subjective cognitive concerns (SCC). The SCC criterion is presently unstandardized, possibly limiting risk detection. We sought to: 1. Characterize SCC practices through MCR literature review; 2. Investigate the ability of SCC in slow gait individuals in predicting the likelihood of cognitive
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Develop and validate a prognostic index with laboratory tests to predict mortality in middle-aged and older adults using machine learning models: a prospective cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-13 Chi-Hsien Huang, Yao-Hwei Fang, Shu Zhang, I-Chien Wu, Shu-Chun Chuang, Hsing-Yi Chang, Yi-Fen Tsai, Wei-Ting Tseng, Ray-Chin Wu, Yen-Tze Liu, Li-Ming Lien, Chung-Chou Juan, Chikako Tange, Rei Otsuka, Hidenori Arai, Chih-Cheng Hsu, Chao Agnes Hsiung
Background Prognostic indices can enhance personalized predictions of health burdens. However, a simple, practical and reproducible tool is lacking for clinical use. This study aimed to develop a machine learning-based prognostic index for predicting all-cause mortality in community-dwelling elderly individuals. Methods We utilized the Healthy Aging Longitudinal Study in Taiwan (HALST) cohort, encompassing
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Associations of Neurological Biomarkers in Serum with Gait Measures: The Cardiovascular Health Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-09 Abhijay Nadkarni, Kenneth J Mukamal, Xiaonan Zhu, David Siscovick, Jennifer S Brach, Mini Jacob, Sudha Seshadri, Temidayo Abe, Caterina Rosano, Luc Djousse, Andrea L Rosso
Background Gait impairment leads to increased mobility decline and may have neurological contributions. This study explores how neurological biomarkers are related to gait in older adults. Methods We studied participants in the Cardiovascular Health Study, a population-based cohort of older Americans, who underwent a serum biomarker assessment from samples collected in 1996-97 for neurofilament light-chain
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Effects of China's Clean Air Act on Frailty Levels among Middle-Aged and Older Adults: A Population-Based Quasi-Experimental Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-08 Yujia Guo, Fan Yang
Background Air pollution is a frailty risk factor, yet the frailty-related health benefits of China's air pollution control policy, the Clean Air Action (CCAA), are unclear. Frailty progression and transitions differ among robust, prefrail, and frail adults. This study aimed to evaluate the CCAA's effect on frailty levels among robust, prefrail, and frail Chinese adults. Methods Using propensity score
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Musculoskeletal Pain Characteristics and Objectively Measured Physical Activity in Older Adults J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-04 Yurun Cai, Fangyu Liu, Amal A Wanigatunga, Jacek K Urbanek, Eleanor M Simonsick, Luigi Ferrucci, Jennifer A Schrack
Background Pain is associated with reports of restricted physical activity (PA), yet the association between musculoskeletal pain characteristics and objectively measured PA quantities and patterns in late life is not well understood. Methods A total of 553 adults (mean age 75.8±8.4 years, 54.4% women) in the Baltimore Longitudinal Study of Aging (BLSA) completed a health interview and subsequent 7-day
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Genetic Correlates of Biological Aging and the Influence on Prediction of Mortality J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-02 Oluwasefunmi Akeju, Michelle M J Mens, Robert Warmerdam, Marjolein Dijkema, Anita H J van den Biggelaar, Lude Franke, Jaap Goudsmit, Julia W Wu
Longevity and disease-free survival are influenced by a combination of genetics and lifestyle. Biological age (BioAge), a measure of aging based on composite biomarkers, may outperform chronological age in predicting health and longevity. This study investigated the relationship between genetic risks, lifestyle factors and delta age (Δage), estimated as the difference between biological and chronological
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The potential role and therapeutic relevance of cellular senescence in skeletal pathophysiology J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-02 Bo Li, Ping Lyu, Jinru Tang, Jingya Li, Takehito Ouchi, Yi Fan, Zhihe Zhao, Longjiang Li
Biological aging profoundly impairs the homeostasis of the skeletal system. Cellular senescence, a hallmark of biological aging, plays an instrumental role in bone disease. The underlying mechanisms of cellular senescence, triggered by both intracellular and extracellular stimuli, are multifaceted and yet to be uncovered. Recent research indicates that acute cellular senescence often serves beneficial
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Trend in Respite Use by Race Among Caregivers for People Living with Dementia J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-02 Yeunkyung Kim, Jihye Kim, Hyunjee Kim, Sungchul Park, Yue Li
Background Respite care provides short-term relief for caregivers. Despite efforts to promote respite use among Black caregivers, little is known if disparities in respite use between Black and White dementia caregivers have decreased over time. We examined a trend nationally to see if more recent efforts may have helped reduce disparities in respite use. Methods We used a repeated cross-sectional
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Dance Exergames for Older Adults: A Systematic Review and Meta-Analysis With Narrative Synthesis J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-02-02 Si Qi Yoong, Vivien Xi Wu, Changwu Chen, Poh Yin Lee, Karen Siew Lin Wee, Justina Teo, Matthew Chin Heng Chua, Ying Jiang
Background A systematic review and meta-analysis with narrative synthesis was conducted to evaluate the impact of dance exergaming on older adults' health-related outcomes and its feasibility, usability, and safety. Methods PubMed, Scopus, CINAHL, Web of Science, The Cochrane Library, ProQuest Dissertations and Theses Global and Google Scholar were searched from inception to 7 December 2023. Interventional
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Meeting summary of The NYO3 5th NO-Age/AD meeting and the 1st Norway-UK joint meeting on ageing and dementia: recent progress on the mechanisms and interventional strategies J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-30 He-Ling Wang, Richard Siow, Tomas Schmauck-Medina, Jianying Zhang, Per Morten Sandset, Clare Filshie, Øystein Lund, Linda Partridge, Linda Hildegard Bergersen, Lene Juel Rasmussen, Konstantinos Palikaras, Ioannis Sotiropoulos, Jon Storm-Mathisen, David C Rubinsztein, Maria Grazia Spillantini, Chris I De Zeeuw, Leiv Otto Watne, Martin Vyhnalek, Katerina Veverova, Kristina Xiao Liang, Nektarios Tavernarakis
Unhealthy ageing poses a global challenge with profound healthcare and socioeconomic implications. Slowing down the ageing process offers a promising approach to reduce the burden of a number of age-related diseases, such as dementia, promoting healthy longevity in the old population. In response to the challenge of the ageing population and with a view to the future, Norway and the UK are fostering
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Associations Between Prior Head Injury, Physical Functioning, and Frailty in the Atherosclerosis Risk in Communities (ARIC) Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-29 Katherine J Hunzinger, Alexa E Walter, Kimberly A Rosenthal, B Gwen Windham, Priya Palta, Stephen P Juraschek, Caitlin W Hicks, Rebecca F Gottesman, Andrea L C Schneider
Background Older adults have the highest rates of head injury and are at the greatest risk for subsequent dysfunction, yet research on subsequent physical decline is limited. We sought to examine cross-sectional and prospective associations of head injury with physical functioning and frailty among older adults. Methods 5,598 Atherosclerosis Risk in Communities Study participants from visit 5 (2011-2013)
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Differences in falls and physical activity in older women from two generations J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-29 Wing S Kwok, Saman Khalatbari-Soltani, Xenia Dolja-Gore, Julie Byles, Juliana S Oliveira, Marina B Pinheiro, Catherine Sherrington
Background Falls and physical inactivity increase with age. However, physical activity, falls and their associations in older people born at different times is unclear. Methods Women born 1921-26 and 1946-51 who completed follow-up questionnaires in 1999 (n=8,403, mean (SD) age: 75 (1) years) and 2019 (n=7,555, 71 (1) years) in the Australian Longitudinal Study on Women’s Health. Self-reported non-injurious
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Examining the role of frailty on treatment patterns and complications among older women undergoing procedure-based treatment for urinary incontinence J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-27 Candace Y Parker-Autry, Scott Bauer, Cassie Ford, W Thomas Gregory, Gopal Badlani, Charles D Scales
Background Aging beyond 65 years is associated with increased prevalence of urinary incontinence (UI), frailty, and increased complication rate with UI treatments. To investigate this relationship, we examined frailty as a predictor of procedure-based UI treatment patterns and urologic complications in Medicare-eligible women. Methods We identified women undergoing procedures for UI between 2011-2018
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Changes in Expression of Key Genes in Alzheimer's Disease: A Specific Brain Tissue Change J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-25 Lucas Trevizani Rasmussen, Roger Willian de Labio, Mônica Pezenatto dos Santos, Bruno Mari Fredi, Eduardo Federighi Baisi Chagas, Elizabeth Suchi Chen, Gustavo Turecki, Marília de Arruda Cardoso Smith, Spencer Luiz Marques Payão
Alzheimer's disease (AD) is an irreversible and neurodegenerative disorder. Its etiology is not clear, but the involvement of genetic components plays a central role in the onset of the disease. In the present study, the expression of ten genes (APP, PS1 and PS2, APOE, APBA2, LRP1, GRIN2B, INSR, GJB1, and IDE) involved in the main pathways related to Alzheimer's disease were analyzed in auditory cortices
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Interferon Regulatory Factor 5 Regulates the Phagocytosis of Microglia and Alleviate Alzheimer’s Pathology J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-25 Ziqi Fan, Xinyi Zhang, Shuai Zhao, Siyan Zhong, Zheyu Li, Yaping Yan, Baorong Zhang, Yanxing Chen
Microglia play a critical role in the pathophysiology of Alzheimer’s disease (AD). They are involved in Aβ-induced neuroinflammatory responses, regulating the production of inflammatory mediators. Interferon regulatory factor 5 (IRF5) plays a central role in inflammatory diseases in the periphery, the role of which in CNS remains elusive. This study aimed to investigate the role of IRF5 in Aβ-induced
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Associations between Walking Speed and Gut Microbiome Composition in Older Men from the MrOS Study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-25 Samaneh Farsijani, Jane A Cauley, Peggy M Cawthon, Lisa Langsetmo, Eric S Orwoll, Deborah M Kado, Douglas P Kiel, Anne B Newman
Background Gut dysbiosis has been linked to frailty, but its association with early mobility decline is unclear. Methods First, we determined the cross-sectional associations between walking speed and the gut microbiome in 740 older men (84 ± 4y) from the MrOS cohort with available stool samples and 400m walking speed measured in 2014–16. Then, we analyzed the retrospective longitudinal associations
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Murine myoblasts exposed to SYUIQ-5 acquire senescence phenotype and differentiate into sarcopenic-like myotubes, an in vitro study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-25 Laura Gerosa, Amir Mohammad Malvandi, Marta Gomarasca, Chiara Verdelli, Veronica Sansoni, Martina Faraldi, Ewa Ziemann, Fabiola Olivieri, Giuseppe Banfi, Giovanni Lombardi
The musculoskeletal system is one of the most affected organs by aging that correlates well with an accumulation of senescent cells as for other multiple age related pathologies. The molecular mechanisms underpinning muscle impairment because of senescent cells are still elusive. Availability of in vitro model of skeletal muscle senescence is limited and restricted to a small panel of phenotypic features
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Exome-wide sequencing study identified genetic variants associated with sarcopenic obesity J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-25 Qian Xu, Qi-Gang Zhao, Xin-Ling Ma, Shan-Shan Yan, Bai-Xue Han, Zi-Tong Song, Fan Bu, Kuan Li, Lei Zhang, Yu-Fang Pei
Sarcopenic obesity (SO) is an age-related disease characterized by the coexistence of excessive adiposity and low muscle mass or function. While obesity and sarcopenia are heritable conditions, the genetic determinants of SO have not been fully understood. We conducted a large-scale exome-wide association analysis of SO in a sequenced sample of 2,887 cases and 113,284 controls and an imputed sample
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Body size, diet quality, and epigenetic ageing: cross-sectional and longitudinal analyses J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-25 Danmeng Lily Li, Allison M Hodge, Lachlan Cribb, Melissa C Southey, Graham G Giles, Roger L Milne, Pierre-Antoine Dugué
Epigenetic age is an emerging marker of health that is highly predictive of disease and mortality risk. There is a lack of evidence on whether lifestyle changes are associated with changes in epigenetic ageing. We used data from 1,041 participants in the Melbourne Collaborative Cohort Study with blood DNA methylation measures at baseline (1990-1994, mean age: 57.4 years) and follow-up (2003-2007, mean
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Late-Life Metabolic Dysfunction-Associated Steatotic Liver Disease And Its Association With Physical Disability And Dementia J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-16 Daniel Clayton-Chubb, William W Kemp, Ammar Majeed, Robyn L Woods, Joanne Ryan, Anne M Murray, Trevor T-J Chong, John S Lubel, Cammie Tran, Alexander D Hodge, Hans G Schneider, John J McNeil, Stuart K Roberts
Background The burden of metabolic dysfunction-associated steatotic liver disease (MASLD) is growing rapidly, including among older adults. The number of older adults is also rising with concomitantly increasing rates of age-related physical and cognitive dysfunction. However, data on whether MASLD impacts physical and cognitive function in older adults is limited. As such, we aimed to identify whether
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The association of skeletal muscle energetics with recurrent falls in older adults within the Study of Muscle, Mobility and Aging (SOMMA) J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-11 Philip A Kramer, Ezequiel Zamora, Haley N Barnes, Elsa S Strotmeyer, Nancy W Glynn, Nancy E Lane, Paul M Coen, Peggy M Cawthon, Bret H Goodpaster, Anne B Newman, Stephen B Kritchevsky, Steven R Cummings
Background Falls in the older population are a major public health concern. While many physiological and environmental factors have been associated with fall risk, muscle mitochondrial energetics has not yet been investigated. Methods In this analysis, 835 Study of Muscle, Mobility and Aging (SOMMA) participants aged 70-94 were surveyed for number of falls (total), recurrent falls (2+), and fall-related
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Dynamical network stability analysis of multiple biological ages provides a framework for understanding the aging process J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-11 Glen Pridham, Andrew D Rutenberg
Widespread interest in non-destructive biomarkers of aging has led to a multitude of biological ages that each proffers a ‘true’ health-adjusted individual age. While each measure provides salient information on the aging process, they are each univariate, in contrast to the “hallmark” and “pillar” theories of aging which are explicitly multidimensional, multicausal and multiscale. Fortunately, multiple
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Yo-yo Dieting Delays Male Drosophila melanogaster Aging Through Enhanced Mitochondrial Function, Relative to Sustained High-Calorie Diet Feeding J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-10 Mengliu Luo, Qianhua Yuan, Yutong Xie, Meiqing Mai, Wanhan Song, Ya Wang, Haimei Shi, Enqin Xia, Honghui Guo
Weight regain subsequent to weight reduction resulting from dietary interventions represents a prevalent phenomenon recognized as "Yo-yo dieting." However, the impact of prolonged Yo-yo dieting on health, especially in relation to the aging process, remains poorly understood. This study aimed to investigate the influence of Yo-yo dieting on the aging process in male Drosophila melanogaster that have
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Rho-kinase is differentially expressed in the adipose tissue of rodent and human in response to aging, sex, and acute exercise J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-10 Vitor Rosetto Muñoz, Renan Fudoli Lins Vieira, Carlos Kiyoshi Katashima, Rafael Calais Gaspar, Marsel Lino, Joice Cristina dos Santos Trombeta, Renata Garbellini Duft, Ana Paula Azevêdo Macêdo, Adelino Sanchez Ramos da Silva, Eduardo Rochete Ropelle, Leandro Pereira de Moura, Dennys Esper Cintra, Mara Patricia Traina Chacon-Mikahil, Cláudia Regina Cavaglieri, José Rodrigo Pauli
White adipose tissue (WAT) controls energy storage, expenditure and endocrine function. Rho-kinase (ROCK) is related to impaired thermogenesis, downregulation of preadipocyte differentiation, and adipokine production. Furthermore, WAT ROCK responds to metabolic stress from high-fat diets or diabetes. However, ROCK distribution in adipose depots and its response to aging and sex remain unclear. Thus
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Serum 25-hydroxyvitamin D, vitamin D receptor and vitamin D binding protein gene polymorphisms and risk of dementia among older adults with prediabetes J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-10 Chun Zhou, Xiaoqin Gan, Ziliang Ye, Yanjun Zhang, Sisi Yang, Panpan He, Yuanyuan Zhang, Mengyi Liu, Qimeng Wu, Xianhui Qin
Background The association between vitamin D and dementia risk in those with prediabetes remains uncertain. We aimed to evaluate the association of serum 25-hydroxyvitamin D (25OHD) with incident dementia among older adults with prediabetes, and examine whether Apolipoprotein E (APOE) genotypes, vitamin D receptor (VDR) and vitamin D binding protein (VDBP) gene polymorphisms may modify this association
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Incidence, quality of care, and mortality in hip fracture patients in the course of the COVID pandemic. A population-based cohort study J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-10 Alma B Pedersen, Nickolaj Risbo, Bjarke L Viberg, Henrik Palm, Niels Dieter Röck
Background We assessed the incidence, quality of in-hospital care and mortality for hip fracture (HF) patients in Denmark before and during the COVID pandemic. Methods We obtained data from the Danish registries in the COVID period (11 March 2020 to 27 January 2021, overall and in five periods) and compared to a pre-COVID period (13 March 2019 to 10 March 2020). We calculated the proportion of patients
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Age-Dependent Effects of Voluntary Wheel Running Exercise on Voiding Behavior and Potential Age-Related Molecular Mechanisms in Mice J. Gerontol. A Biol. Sci. Med. Sci. (IF 5.1) Pub Date : 2024-01-09 Teresa T Liu, Laura E Pascal, Scott R Bauer, Hannah N Miles, Jules B Panksepp, Granville L Lloyd, Lingjun Li, Donald B DeFranco, William A Ricke
Background Older men frequently develop lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH). Risk factors for LUTS/BPH include sedentary lifestyle, anxiety/depression, obesity, and frailty, which all increase with age. While physical exercise may reduce the progression and/or severity of LUTS/BPH, the age-related mechanisms responsible remain unknown. Methods Voiding