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Empowering experts by experience to guide ethical precision psychiatry Biol. Psychiatry (IF 10.6) Pub Date : 2023-12-01 Péter Kéri, Lawrence A. White, Dominic Oliver, Paolo Fusar-Poli
Abstract not available
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PHENOTYPIC AND GENETIC ASSOCIATIONS BETWEEN PRESCHOOL FINE MOTOR SKILLS AND LATER NEURODEVELOPMENT, PSYCHOPATHOLOGY, AND EDUCATIONAL ACHIEVEMENT Biol. Psychiatry (IF 10.6) Pub Date : 2023-12-01 Aislinn Bowler, Tomoki Arichi, Pasco Fearon, Emma Meaburn, Jannath Begum-Ali, Greg Pascoe, Mark H. Johnson, Emily J.H. Jones, Angelica Ronald
BACKGROUND Fine motor skills are heritable, comprise important milestones in development, and impairments are associated with neurodevelopmental conditions, psychiatric disorders, and poor educational outcomes. METHODS In a pre-registered study of 9625 preschool children from the Twins Early Development Study, fine motor assessments (drawing, block building, folding, and questionnaires) were conducted
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The Maternal Microbiome as a Map to Understanding the Impact of Prenatal Stress on Offspring Psychiatric Health Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-30 Mary C. Kimmel, Branden Verosky, Helen J. Chen, Oliva Davis, Tamar L. Gur
Stress and psychiatric disorders have been independently associated with disruption of the maternal and offspring microbiome, and with increased risk of the offspring developing psychiatric disorders, both in clinical studies and in preclinical studies. However, the role of the microbiome in mediating the effect of prenatal stress on offspring behavior is unclear. While preclinical studies have identified
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Repetitive transcranial magnetic stimulation-induced neuroplasticity and the treatment of psychiatric disorders: state of the evidence and future opportunities Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-30 Sophie M.D.D. Fitzsimmons, Eva Oostra, Tjardo S. Postma, Ysbrand D. van der Werf, Odile A. van den Heuvel
Neuroplasticity, or activity-dependent neuronal change, is a crucial mechanism underlying the mechanisms of effect of many therapies for neuropsychiatric disorders, one of which is repetitive transcranial magnetic stimulation (rTMS). Understanding the neuroplastic effects of rTMS at different biological scales, different timescales, and how the effects at different scales interact with each other can
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Neuroimaging informed TMS and personalized targeting: evidence, controversies and opportunities Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-29 Robin FH. Cash, Andrew Zalesky
The development of neuroimaging methodologies to map brain connectivity has transformed our understanding of psychiatric disorders, the distributed effects of brain stimulation, and how TMS can be best employed to target and ameliorate psychiatric symptoms. In parallel, neuroimaging research has revealed that higher-order brain regions such as the prefrontal cortex, which represent the most common
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The Biological Psychiatry Cover Art Initiative: Addressing the Underrepresentation of Black People on the Journal Cover Through a Series of Commissioned Artworks Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-27 John H. Krystal, Imo Nse Imeh, Rosa P. Garces, Nii A. Addy
Abstract not available
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Maternal Stress and Vulnerability in Offspring: Hippocampal Mechanisms of Resilience Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-27 Sanne J.H. van Rooij, Abigail Powers
Abstract not available
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Normalizing Uncertain Threat: What Change in Anxiety-Potentiated Startle Can Tell Us About Anxiety Treatment Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-27 Joseph K. Carpenter
Abstract not available
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Ten Simple Rules for Using Machine Learning in Mental Health Research Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-18 Joaquim Radua, Nikolaos Koutsouleris
Abstract not available
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Mapping the relationship of white matter lesions to depression in multiple sclerosis Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-18 Erica B. Baller, Elizabeth M. Sweeney, Matthew C. Cieslak, Timothy Robert-Fitzgerald, Sydney C. Covitz, Melissa L. Martin, Matthew K. Schindler, Amit Bar-Or, Ameena Elahi, Bart S. Larsen, Abigail R. Manning, Clyde E. Markowitz, Christopher M. Perrone, Victoria Rautman, Madeleine M. Seitz, John A. Detre, Michael D. Fox, Russell T. Shinohara, Theodore D. Satterthwaite
Background Multiple sclerosis (MS) is an immune-mediated neurological disorder where up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS. Methods 380 participants with MS were identified via the electronic health record. Depressed individuals (MS+Depression; n=232) included persons with an ICD-10 depression diagnosis, a prescription
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Targeting symptom-specific networks with TMS Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-17 Shan H. Siddiqi, Michael D. Fox
Increasing evidence suggests that the clinical effects of transcranial magnetic stimulation (TMS) are target-dependent. Within any given symptom, precise targeting of specific brain circuits may improve clinical outcomes. This principle can also be extended across symptoms – stimulation of different circuits may lead to different symptom-level outcomes. This may include targeting different symptoms
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Shaping memories via stress: a synaptic engram perspective Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-15 Niek Brosens, Sylvie L. Lesuis, Priyanka Rao-Ruiz, Michel C. van den Oever, Harm J. Krugers
Stress modulates the activity of various memory systems and can thereby guide behavioral interaction with the environment in an adaptive or maladaptive manner. At the cellular level, a large body of evidence indicates that (nor)adrenaline and glucocorticoid release induced by acute stress-exposure affects synapse function and synaptic plasticity, which are critical substrates for learning and memory
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Brain-Wide Mendelian Randomization Study of Anxiety Disorders and Symptoms Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-14 Mihaela-Diana Zanoaga, Eleni Friligkou, Jun He, Gita A. Pathak, Dora Koller, Brenda Cabrera-Mendoza, Murray B. Stein, Renato Polimanti
Background To gain insights into the role of brain structure and function on anxiety (ANX), we conducted a genetically informed investigation leveraging information from ANX genome-wide association studies available from UK Biobank (UKB; N=380,379), FinnGen Program (N=290,361), and Million Veteran Program (MVP; N=175,163) together with UKB genome-wide data (N=33,224) related to 3,935 brain imaging-derived
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Advancing Clinical Psychiatry: Integration of Clinical and Omics Data Using Machine Learning Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-13 Bill Qi, Yannis J. Trakadis
Abstract not available
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Unlocking the Potential of Effective Connectivity as a Neuroimaging Biomarker: A Path Toward Personalized Depression Treatment in Youth Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-13 Kelsey E. Hagan
Abstract not available
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Toward Reproducible, Generalizable, and Clinically Useful Neurophysiological Subtypes of Major Depressive Disorder Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-13 Ye Ella Tian
Abstract not available
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Cilia and Extracellular Vesicles in Brain Development and Disease Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-11 Rong Ma, Liang Chen, Ningyun Hu, Steve Caplan, Guoku Hu
Primary and motile cilia are thin, hair-like cellular projections from the cell surface involved in movement, sensing, and communication between cells. Extracellular vesicles (EVs) are small membrane-bound vesicles secreted by cells and they contain various proteins, lipids, and nucleic acids that are delivered to and influence the behavior of other cells. Both cilia and EVs are essential for the normal
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aBLA and pBLA Projections of Cell Type-Specific D1 Neurons from the mPFC Differentially Control Alcohol-Seeking Behavior Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-10 Ziyi Li, Jiaxin Li, Yanxia Wei, Wanying Zou, Olivia Ewi Vidjro, Jun Wang, Li Zhou, Yongsheng Zhu, Tengfei Ma
BACKGROUND Alcohol use disorder (AUD) is characterized by compulsive alcohol-seeking behavior, which is associated with dysregulation of afferent projections from the medial prefrontal cortex (mPFC) to the basal amygdala (BLA). However, the contribution of the cell-type-specific mechanism in this neuronal circuit to alcohol-seeking behavior remains unclear. METHODS Mice were trained with two-bottle
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On the clinical utility of individualized prediction models for psychosis in at risk youth Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-08 Tyrone D. Cannon
Abstract not available
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Accelerated pace of aging in schizophrenia: Five case-control studies Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-02 Avshalom Caspi, Gemma Shireby, Jonathan Mill, Terrie E. Moffitt, Karen Sugden, Eilis Hannon
Objectives Schizophrenia is associated with increased risk of developing multiple aging-related diseases, including metabolic, respiratory, and cardiovascular diseases, and Alzheimer’s and related dementias, leading to the hypothesis that schizophrenia is accompanied by accelerated biological aging. This has been difficult to test because there is no widely accepted measure of biological aging. Epigenetic
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Neural markers of emotion reactivity and regulation before and after a targeted social rejection: Differences among girls with and without suicidal ideation and behavior histories Biol. Psychiatry (IF 10.6) Pub Date : 2023-11-02 Adam Bryant Miller, Jessica Jenness, Amanda Elton, Andrea Pelletier-Baldelli, Kinjal Patel, Adrienne Bonar, Sophia Martin, Gabriel Dichter, Matteo Giletta, George M. Slavich, Karen D. Rudolph, Paul Hastings, Matthew Nock, Mitchell J. Prinstein, Margaret Sheridan
Background Suicidal thoughts and behaviors (STBs) are common among adolescent girls and increase risk for suicide death. Emotion regulation difficulties are linked with STBs, particularly in response to targeted social rejection. However, neural correlates of this link have not been investigated and may identify novel targets for interventions. Here, we examine neural correlates of emotion regulation
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Hippocampal circAnk3 Deficiency Causes Anxiety-like Behaviors and Social Deficits by Regulating the miR-7080-3p/IQGAP1 Pathway in Mice Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-30 Yuman He, Linhong Jiang, Haxiaoyu Liu, Qian Bu, Weihong Kuang, Ying Zhao, Yaxing Chen, Ni Zhang, Yuzhou Xiao, Shu Li, Rong Chen, Shuang Han, Yuanyi Zhou, Jiamei Zhang, Xuemei Wan, Rui Xu, Shaomin Wang, Haoluo Zhang, Hui Gu, Qingfan Wei, Xiaobo Cen
Background Circular RNAs (circRNAs) are highly enriched in the synapses of the mammalian brain and play important roles in neurological function by acting as molecular sponges of microRNAs (miRNAs). CircAnk3 is derived from the 11th intron of the Ankyrin 3 (Ank3) gene, a strong genetic risk factor for neuropsychiatric disorders; however, the function of circAnk3 remains elusive. In this study, we investigated
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What Are the Problems With Substance Use? Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-30 Marc N. Potenza
Abstract not available
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Existing and future strategies to manipulate the gut microbiota with diet as a potential adjuvant treatment for psychiatric disorders. Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-31 Fiona Catherine Ross, Dylan E. Mayer, Arpana Gupta, Chris Ian Richard Gill, Daniele Del Rio, John Francis Cryan, Aonghus Lavelle, Reynolds Paul Ross, Catherine Stanton, Emeran Anton Mayer
Nutrition and diet quality play key roles in preventing and slowing cognitive decline and have been linked to multiple brain disorders. This review compiles available evidence from preclinical studies and clinical trials on the impact of nutrition and interventions regarding major psychiatric conditions and some neurological disorders. We emphasize the potential role of diet-related microbiome alterations
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The Dorsal Raphe as a Regulator of Emotion and Reward: Beyond Pain Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-30 Randal A. Serafini, Venetia Zachariou
Abstract not available
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A Developmental Brain Circuit–Based Psychiatry Approach to Social Reinforcement Processing During Adolescence Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-30 Daniel Martins
Abstract not available
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Supplementary Motor Area Cortical Neuron Membrane Properties: Key Determinant for Cocaine-Seeking Behaviors Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-30 Carole Morel
Abstract not available
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Disengagement of somatostatin neurons from lateral septum circuitry by oxytocin and vasopressin restores social-fear extinction and suppresses aggression outbursts in Prader-Willi syndrome model Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-29 Yann Dromard, Amélie M. Borie, Prabahan Chakraborty, Françoise Muscatelli, Gilles Guillon, Michel G. Desarménien, Freddy Jeanneteau
Background Responding to social signals by expressing the correct behavior is not only challenged in autism, but also in diseases with high prevalence of autism, like Prader-Willi Syndrome (PWS). Clinical evidence suggests aberrant pro-social behavior in patients can be regulated by intranasal oxytocin (OXT) or vasopressin (AVP). However, what neuronal mechanisms underlie impaired behavioral responses
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Link Stress-Related Gut Microbiota Shifts to Mental Health Outcomes Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-29 Annelise A. Madison, Michael T. Bailey
Stress levels are surging, alongside the incidence of stress-related psychiatric disorders. Perhaps a related phenomenon, especially in urban areas, the human gut contains fewer bacterial species than ever before. Although the functional implications of this absence is unclear, one consequence may be reduced stress resilience. Preclinical and clinical evidence has shown how stress exposure can alter
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Brain Circuits Involved in Transcranial Magnetic Stimulation Response in Adults Are Connected to a Similar Prefrontal Target in Children Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-24 Joseph J. Taylor, Stephan T. Palm, Alexander Li Cohen, Paul E. Croarkin, William Drew, Michael D. Fox, Shan Siddiqi
Abstract not available
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A protective role of low polygenic risk score in healthy individuals carrying ADHD-associated CNVs Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-21 Xiao Chang, Huiqi Qu, Yichuan Liu, Joseph Glessner, Hakon Hakonarson
Background Previous studies have implicated both rare copy number variations (CNVs) and common variants in liability for Attention deficit hyperactivity disorder (ADHD). However, how common and rare genetic variants jointly contribute to individual liability requires further investigation in larger cohorts. Methods This study is comprised of 9,385 subjects of European decedent and 7,810 subjects of
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Depression in Alzheimer’s disease: epidemiology, mechanisms, and treatment Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-20 Yu-Yuan Huang, Yi-Han Gan, Liu Yang, Wei Cheng, Jin-Tai Yu
Depression and Alzheimer's disease (AD) are substantial public health concerns. In the past decades, a link between two disease entities has received extensive acknowledgment, yet the complex nature of this relationship has demanded further clarification. Some evidence indicates that mid-life depression may be an AD risk factor, while a chronic course of depression in late life may be a precursor to
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5HT1A receptors on dentate gyrus granule cells confer stress resilience Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-18 John Gregory Bickle, Yifei Li, Amira Millette, Rushell Dixon, Serena Wu, Elena Carazo Arias, Victor Mari Luna, Christoph Anacker
Background Hyperactivity of granule cells in the ventral dentate gyrus (vDG) promotes vulnerability to chronic stress. However, which receptors in the vDG could be targeted to inhibit this hyperactivity and confer stress resilience is not known. The serotonin 1A receptor (5HT1AR) is a Gi protein coupled inhibitory receptor that has been implicated in stress adaptation, anxiety, depression, and antidepressant
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Frontal Theta Helps to Explain Etiological Variability Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-16 James F. Cavanagh
Abstract not available
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The East Asian–Specific Risk Genes in Autism Spectrum Disorder Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-16 Kota Tamada, Toru Takumi
Abstract not available
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Linking Neurogenetics and Functional Connectivity in Autism Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-16 Michael Hawrylycz, Thomas Nickl-Jockschat
Abstract not available
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Adolescence, the microbiota-gut-brain axis, and the emergence of psychiatric disorders Biol. Psychiatry (IF 10.6) Pub Date : 2023-10-13 Sadie F. McVey Neufeld, Matthew Ahn, Wolfgang A. Kunze, McVey Neufeld Karen-Anne
Second only to early life, adolescence is a period of dramatic change and growth. For the developing young adult, this is occurring on a backdrop of distinct environmental challenges and stressors. A significant body of work now identifies an important role for the microbiota-gut-brain (MGB) axis in the development and function of the brain. Given that the MGB axis is both highly plastic during the