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Designing Clinical Trials for an Inflammatory Subtype of Major Depressive Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2025-04-10 Andrew H. Miller, Jennifer C. Felger, Ebrahim Haroon
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Biological Psychiatry: Preserving the Promise Biol. Psychiatry (IF 9.6) Pub Date : 2025-04-09 John H. Krystal, Cameron S. Carter, Carrie E. Bearden, Deanna M. Barch, Editors and Editorial Boards of Biological Psychiatry Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science, Editorial Committee of the Biological Psychiatry family of journals, Society of Biological Psychiatry
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Preclinical Models for Schizophrenia and Sleep Oscillations: From Biomarkers to Mechanisms Biol. Psychiatry (IF 9.6) Pub Date : 2025-04-08 Vladyslav V. Vyazovskiy, David M. Bannerman
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Prosocial Helping Behavior: Conceptual Issues and Neural Mechanisms Biol. Psychiatry (IF 9.6) Pub Date : 2025-03-14 Nicole Rigney, Weizhe Hong
Prosocial helping behavior, characterized by voluntary actions taken to benefit others, plays a vital role in promoting cooperation and maintaining social bonds across human and animal social groups. In this review, we examine key conceptual issues surrounding prosocial behavior, focusing specifically on targeted helping and comforting actions. We outline the behavioral paradigms used to study these
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Emergence and Dynamics of Delusions and Hallucinations Across Stages in Early Psychosis Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-26 Catalina Mourgues-Codern, David Benrimoh, Jay Gandhi, Emily A. Farina, Raina Vin, Tihare Zamorano, Deven Parekh, Ashok Malla, Ridha Joober, Martin Lepage, Srividya N. Iyer, Jean Addington, Carrie E. Bearden, Kristin S. Cadenhead, Barbara Cornblatt, Matcheri Keshavan, William S. Stone, Daniel H. Mathalon, Diana O. Perkins, Elaine F. Walker, Tyrone D. Cannon, Scott W. Woods, Jai L. Shah, Albert R. Powers
Hallucinations and delusions are often grouped together as positive symptoms of psychosis. However, recent evidence suggests that they may be driven by distinct computational and neural mechanisms. Examining the time course of their emergence may provide insights into the relationship between these underlying mechanisms.
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The Neuropsychiatric Checklist for Autoimmune Psychosis: A Narrative Review Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-21 Ludger Tebartz van Elst, Kimon Runge, Philipp T. Meyer, Horst Urbach, Nils Venhoff, Harald Prüss
Autoimmune encephalitis (AE) is a rapidly evolving topic in both neurology and psychiatry. A recent international consensus article defined criteria for possible, probable, and definite autoimmune psychosis (AP) inspired by the principles established in neurology for the definition of AE. This has stimulated much clinical research on AP but also criticism of the validity of the criteria for possible
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Incorporating Polygenic Liability and Family History for Predicting Psychiatric Diseases in the Taiwan Biobank Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-19 Shi-Heng Wang, Yen-Chen A. Feng, Mei-Chen Lin, Chi-Fung Cheng, Mei-Hsin Su, Chia-Yen Chen, Chi-Shin Wu, Chun Chieh Fan
In this study, we investigated the interplay between molecular measures of polygenic risk scores (PRSs) and conventional measures of family history (FH) on the risk of 4 psychiatric disorders: schizophrenia (SCZ), bipolar disorder (BPD), major depressive disorder (MDD), and obsessive-compulsive disorder (OCD) in community samples of East Asian populations. We examined the individual and joint associations
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Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-19 Dennis van der Meer, Guy Hindley, Alexey A. Shadrin, Olav B. Smeland, Nadine Parker, Anders M. Dale, Oleksandr Frei, Ole A. Andreassen
Psychiatric disorders have complex genetic architectures with substantial genetic overlap across conditions, which may partially explain their high levels of comorbidity. This presents significant challenges to research. Genome-wide association studies (GWASs) have uncovered hundreds of loci associated with single disorders, but the genetic landscape of psychiatric disorders has remained largely obscure
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Neurobiological Perturbations in Bipolar Disorder Compared With Schizophrenia: Evidence From Cell Cultures and Brain Organoids Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-19 Ibrahim A. Akkouh, Jordi Requena Osete, Attila Szabo, Ole A. Andreassen, Srdjan Djurovic
Bipolar disorder (BD) and schizophrenia (SCZ) are uniquely human disorders with a complex pathophysiology that involves adverse neuropathological events in brain development. High disease polygenicity and limited access to live human brain tissue make these disorders exceedingly challenging to study mechanistically. Cellular cultures and brain organoids generated from human-derived pluripotent stem
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Reply to: Methodological and Interpretational Issues in the PsyRiskMR Database Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-19 Xiaoyan Li, Junfeng Xia
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Methodological and Interpretational Issues in the PsyRiskMR Database Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-19 Jiawei Zhao
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Society of Biological Psychiatry’s 2025 Meeting Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-18 Sophia Frangou M.D. Ph.D., Dost Öngür M.D. Ph.D.
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Global Diversity in Bipolar Disorder: The Role of Cultural and Social Differences With a View to Genomics Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-14 Janice M. Fullerton, Markos Tesfaye
As global gene discovery efforts move away from a historic Eurocentric focus and advance toward embracing more diverse populations, consideration of sociocultural aspects of bipolar disorder (BD) become critical to their success. Diversity can be leveraged to accelerate gene discovery, via different patterns of linkage disequilibrium that lead to greater resolution of mapping association signals, and
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Toward Understanding and Halting Legacies of Trauma Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-14 William Wesley Taylor, Laura Korobkova, Nabeel Bhinderwala, Brian George Dias
Echoes of natural and anthropogenic stressors not only reverberate within the physiology, biology, and neurobiology of the generation directly exposed to them but also within the biology of future generations. With the intent of understanding this phenomenon, significant efforts have been made to establish how exposure to psychosocial stress, chemicals, over- and undernutrition, and chemosensory experiences
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Affective and Social Predictors of Food Consumption During the COVID-19 Lockdown Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-14 Ana Stijovic, Paul Forbes, Ekaterina Pronizius, Anja Feneberg, Giulio Piperno, Urs M. Nater, Claus Lamm, Giorgia Silani
COVID-19 lockdowns were linked to a surge in unhealthy food–related behaviors, potentially as an attempt to cope with disrupted social homeostasis. Here, we tested bidirectional associations between momentary psychological states and prospective food consumption and the moderation of these associations by quality and quantity of social interactions.
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Prediction of Treatment Outcome in Bipolar Disorder: When Can We Expect Clinical Relevance? Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-13 Katie Scott, Anouar Khayachi, Martin Alda, Abraham Nunes
Long-term pharmacological treatment is the cornerstone of the management of bipolar disorder (BD). Clinicians typically select mood-stabilizing medications from among several options through trial and error. This process could be optimized by using robust predictors of treatment response. We review clinical features and biological markers studied in relation to outcome of long-term treatment of BD
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The Drug Discovery Drought in Bipolar Disorder: Barriers and Solutions Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-13 Jee Hyun Kim, Ken Walder, Bruna Panizzutti, Lana J. Williams, Michael Berk
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Transcriptional and Neurochemical Signatures of Cerebral Blood Flow Alterations in Individuals With Schizophrenia or at Clinical High Risk for Psychosis Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-07 Samuel R. Knight, Leyla Abbasova, Yashar Zeighami, Justine Y. Hansen, Daniel Martins, Fernando Zelaya, Ottavia Dipasquale, Thomas Liu, David Shin, Matthijs Bossong, Matilda Azis, Mathilde Antoniades, Oliver D. Howes, Ilaria Bonoldi, Alice Egerton, Paul Allen, Owen O’Daly, Philip McGuire, Gemma Modinos
The brain integrates multiple scales of description, from the level of cells and molecules to large-scale networks and behavior. Understanding relationships across these scales may be fundamental to advancing understanding of brain function in health and disease. Recent neuroimaging research has shown that functional brain alterations that are associated with schizophrenia spectrum disorders (SSDs)
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Epigenetic Control of an Auxiliary Subunit of Voltage-Gated Sodium Channels Regulates the Strength of Drug-Cue Associations and Relapse-Like Cocaine Seeking Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-07 Daniel J. Wood, Evgeny Tsvetkov, Susana Comte-Walters, Colin L. Welsh, Michelle Bloyd, Timothy G. Wood, Rose Marie Akiki, Ethan M. Anderson, Rachel D. Penrod, Lalima K. Madan, Lauren E. Ball, Makoto Taniguchi, Christopher W. Cowan
Repeated use of addictive drugs produces long-lasting and prepotent drug-cue associations that increase vulnerability for relapse in individuals with a substance use disorder. Epigenetic factors, such as HDAC5 (histone deacetylase 5), play a key role in regulating the formation of drug-cue associations, but the underlying mechanisms remain unclear.
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Empirical Classification of Neuropsychiatric Symptoms and Association of Classes With Diagnostic Progression and Cognitive Decline in Mild Cognitive Impairment and Alzheimer’s Disease Populations Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-06 Jong-Il Park, Seonjoo Lee, Benjamin Huber, Davangere P. Devanand, Hyun Kim, Terry E. Goldberg, Alzheimer’s Disease Neuroimaging Initiative
The current study aimed to identify classes of cognitively impaired older individuals based on their neuropsychiatric symptoms (NPSs) and to investigate the contribution of NPS class to cognitive decline and Alzheimer’s disease (AD) risk in mild cognitive impairment (MCI).
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A Critical Role of Philanthropic Support in Paving the Way to Precision Medicine for Bipolar Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-06 Daniel L. Pham, Emily G. Baxi, Kelsey M. Barcomb, Veronica C. Beck, Katherine E. Burdick, Mark A. Frye, Eric J. Nestler, Cara M. Altimus
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Identification and External Validation of a Problem Cannabis Risk Network Biol. Psychiatry (IF 9.6) Pub Date : 2025-02-03 Sarah D. Lichenstein, Brian D. Kiluk, Marc N. Potenza, Hugh Garavan, Bader Chaarani, Tobias Banaschewski, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sarah Hohmann, Nathalie Holz, Christian Baeuchl, Michael N. Smolka
Cannabis use is common, particularly during emerging adulthood when brain development is ongoing, and its use is associated with harmful outcomes for a subset of people. An improved understanding of the neural mechanisms underlying risk for problem-level use is critical to facilitate the development of more effective prevention and treatment approaches.
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Interneuron Loss and Microglia Activation by Transcriptome Analyses in the Basal Ganglia of Tourette Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-30 Yifan Wang, Liana Fasching, Feinan Wu, Milovan Suvakov, Anita Huttner, Sabina Berretta, Rosalinda Roberts, James F. Leckman, Thomas V. Fernandez, Alexej Abyzov, Flora M. Vaccarino
Tourette disorder (TS) is characterized by motor hyperactivity and tics that are believed to originate in the basal ganglia. Postmortem immunocytochemical analyses has revealed decreases in cholinergic (CH), as well as parvalbumin and somatostatin GABA (gamma-aminobutyric acid) interneurons (INs) within the caudate/putamen of individuals with TS.
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Investigating the Contribution of Coding Variants in Alcohol Use Disorder Using Whole-Exome Sequencing Across Ancestries Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-30 Lu Wang, Henry R. Kranzler, Joel Gelernter, Hang Zhou
Alcohol use disorder (AUD) is a leading cause of death and disability worldwide. There has been substantial progress in identifying genetic variants that underlie AUD. However, whole-exome sequencing studies of AUD have been hampered by the lack of available samples.
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Comparative Perspectives on Neuropeptide Function and Social Isolation Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-30 Kenta Asahina, Moriel Zelikowsky
Chronic social isolation alters behavior across animal species. Genetic model organisms such as mice and flies provide crucial insight into the molecular and physiological effects of social isolation on brain cells and circuits. Here, we comparatively review recent findings regarding the function of conserved neuropeptides in social isolation in mice and flies. Analogous functions of 3 classes of
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Two-Month Cognitive Changes Enhance Prediction of Nonremission in Clinical High-Risk Individuals Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-30 TianHong Zhang, YanYan Wei, XiaoChen Tang, LiHua Xu, HuiRu Cui, YeGang Hu, HaiChun Liu, ZiXuan Wang, Tao Chen, YingYing Tang, ZhengHui Yi, ChunBo Li, JiJun Wang
Longitudinal changes in cognitive function may be crucial in predicting clinical outcomes in clinical high-risk (CHR) individuals. In this study, we aimed to investigate the predictive value of baseline cognitive impairment and short-term cognitive changes for nonremission and conversion to psychosis in individuals at CHR for psychosis compared with healthy control individuals (HCs).
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Hippocampal DNA Methylation Promotes Contextual Fear Memory Persistence by Facilitating Systems Consolidation and Cortical Engram Stabilization Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-27 Janina Kupke, Stefanos Loizou, C. Peter Bengtson, Carsten Sticht, Ana M.M. Oliveira
Long-term fear memory storage involves gradual reorganization of supporting brain regions over time, a process termed systems consolidation. Memories initially rely on the hippocampus but gradually shift dependence to the neocortex. Although hippocampal activity drives this transfer, the molecular basis of systems consolidation is largely unknown. DNA methylation changes accompany persistent fear memory
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Grasping Posttraumatic Stress Disorder From the Perspective of Psychoneuroimmunoendocrinology: Etiopathogenic Mechanisms and Relevance for Integrative Management Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-27 Oscar Fraile-Martinez, Cielo García-Montero, Miguel Ángel Álvarez-Mon, Carlos Casanova-Martín, Daniel Fernández-Faber, Marta Presa, Guillermo Lahera, Laura Lopez-Gonzalez, Raúl Díaz-Pedrero, José V. Saz, Melchor Álvarez-Mon, Miguel A. Sáez, Miguel A. Ortega
Posttraumatic stress disorder (PTSD) is a debilitating condition caused by exposure to traumatic events that affects 5% to 10% of the population, with increased prevalence among women and individuals in war zones. Beyond psychological symptoms, PTSD induces significant physiological changes across systems. Psychoneuroimmunoendocrinology (PNIE) offers a framework to explore these complex interactions
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Nuclear Calcium Signaling in D1 Receptor–Expressing Neurons of the Nucleus Accumbens Regulates Molecular, Cellular, and Behavioral Adaptations to Cocaine Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-27 Estefani Saint-Jour, Marie-Charlotte Allichon, Andry Andrianarivelo, Enrica Montalban, Claire Martin, Lisa Huet, Nicolas Heck, Anna M. Hagenston, Aisha Ravenhorst, Mélanie Marias, Nicolas Gervasi, Faustine Arrivet, Adèle Vilette, Katleen Pinchaud, Sandrine Betuing, Thomas Lissek, Jocelyne Caboche, Hilmar Bading, Peter Vanhoutte
The persistence of cocaine-evoked adaptations relies on gene regulations within the reward circuit, especially in the ventral striatum (i.e., nucleus accumbens [NAc]). Notably, activation of the ERK (extracellular signal-regulated kinase) pathway in the striatum is known to trigger a transcriptional program shaping long-term responses to cocaine. Nuclear calcium signaling has also been shown to control
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Characterizing Brainstem GLP-1 Control of Sensory-Specific Satiety in Male and Female Rats Across the Estrous Cycle Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-22 Sarah V. Applebey, Allison G. Xiao, Erin P. Harris, Caleb Levine, Drew L. Belser, Caroline E. Geisler, Marise B. Parent, Debra A. Bangasser, Richard C. Crist, Benjamin C. Reiner, Matthew R. Hayes
Meal variety promotes overconsumption by delaying sensory-specific satiety (SSS), the transient reduction in reward value of a recently consumed food. Despite its role in meal cessation, the neuroendocrine mechanisms that underlie SSS are largely unknown.
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Transcranial Direct Current Stimulation Improves Paranoia and Social Functioning in Schizophrenia: A Randomized Clinical Trial Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-22 Linlin Fan, Sara Carrico, Yiyi Zhu, Robert A. Ackerman, Amy E. Pinkham
Innovative treatments for paranoia, which significantly impairs social functioning in schizophrenia spectrum disorders (SSDs), are urgently needed. The pathophysiology of paranoia implicates the amygdala–prefrontal cortex (PFC) circuits; thus, in this study, we systematically investigated whether transcranial direct current stimulation (tDCS) to the ventrolateral PFC can attenuate paranoia and improve
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Alterations in Prefrontal Cortical Somatostatin Neurons in Schizophrenia: Evidence for Weaker Inhibition of Pyramidal Neuron Dendrites Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-21 Samuel J. Dienel, Kirsten L. Wade, Kenneth N. Fish, David A. Lewis
Certain cognitive processes require inhibition provided by the somatostatin (SST) class of GABA (gamma-aminobutyric acid) neurons in the dorsolateral prefrontal cortex (DLPFC). This inhibition onto pyramidal neuron dendrites depends on both SST and GABA signaling. Although SST messenger RNA (mRNA) levels are lower in the DLPFC in schizophrenia, it is not known whether SST neurons exhibit alterations
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Speak and You Shall Predict: Evidence That Speech at Initial Cocaine Abstinence Is a Biomarker of Long-Term Drug Use Behavior Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-20 Carla Agurto, Guillermo A. Cecchi, Sarah King, Elif K. Eyigoz, Muhammad A. Parvaz, Nelly Alia-Klein, Rita Z. Goldstein
Valid scalable biomarkers for predicting longitudinal clinical outcomes in psychiatric research are crucial for optimizing intervention and prevention efforts. Here, we recorded spontaneous speech from initially abstinent individuals with cocaine use disorder (iCUDs) for use in predicting drug use outcomes.
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Descriptives and Genetic Correlates of Eating Disorder Diagnostic Transitions and Presumed Remission in the Danish Registry Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-17 Mohamed Abdulkadir, Janne Tidselbak Larsen, Loa Clausen, Christopher Hübel, Clara Albiñana, Laura M. Thornton, Bjarni J. Vilhjálmsson, Cynthia M. Bulik, Zeynep Yilmaz, Liselotte Vogdrup Petersen
Eating disorders (EDs) are serious psychiatric disorders with an estimated 3.3 million healthy life-years lost worldwide yearly. Understanding the course of illness, diagnostic transitions and remission, and their associated genetic correlates could inform both ED etiology and treatment. We investigated occurrences of ED transitions and presumed remission and their genetic correlates as captured by
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Mapping the Cerebrospinal Fluid Proteome in Bipolar Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-17 Andreas Göteson, Jessica Holmén-Larsson, Hatice Celik, Aurimantas Pelanis, Carl M. Sellgren, Timea Sparding, Erik Pålsson, Henrik Zetterberg, Kaj Blennow, Lina Jonsson, Johan Gobom, Mikael Landén
Bipolar disorder (BD) is a severe psychiatric condition with unclear etiology and no established biomarkers. Here, we aimed to characterize the cerebrospinal fluid (CSF) proteome in euthymic individuals with BD to identify potential protein biomarkers.
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Stress and Cognition: From Bench to Bedside? Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-15 Lars Schwabe, Nikolaos P. Daskalakis
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Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-14 Olivia Surgent, Derek S. Andrews, Joshua K. Lee, Joseph Boyle, Andrew Dakopolos, Meghan Miller, Sally Ozonoff, Sally J. Rogers, Marjorie Solomon, David G. Amaral, Christine Wu Nordahl
Fine motor challenges are prevalent in autistic populations. However, little is known about their neurobiological underpinnings or how their related neural mechanisms are influenced by sex. The dorsal striatum, which comprises the caudate nucleus and putamen, is associated with motor learning and control and may hold critical information. We investigated how autism diagnosis and sex assigned at birth
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Personalized Theta Burst Stimulation Enhances Social Skills in Young Minimally Verbal Children With Autism: A Double-Blind Randomized Controlled Trial Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-10 Jinming Xiao, Yating Ming, Lei Li, Xinyue Huang, Yuanyue Zhou, Jianjun Ou, Juan Kou, Rui Feng, Rui Ma, Qingyu Zheng, Xiaolong Shan, Yao Meng, Wei Liao, Yingli Zhang, Ting Wang, Yangying Kuang, Jing Cao, Shijun Li, Hua Lai, Jia Chen, Qi Wang, Xiaoli Dong, Xiaodong Kang, Huafu Chen, Vinod Menon, Xujun Duan
Minimally verbal children with autism are understudied and lack effective treatment options. Personalized continuous theta burst stimulation (cTBS) targeting the amygdala and its circuitry may be a potential therapeutic approach for this population.
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Bipolar Disorder and Artistic Temperament: Mechanisms Linking Creativity and Bipolar Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-10 Mikael Landén
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Focused Ultrasound Neuromodulation: Exploring a Novel Treatment for Severe Opioid Use Disorder Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-09 Ali Rezai, Daisy G.Y. Thompson-Lake, Pierre-François D’Haese, Nathalie Meyer, Manish Ranjan, Daniel Farmer, Victor Finomore, Jennifer L. Marton, Sally Hodder, Jeffrey Carpenter, Aniruddha Bhagwat, James Berry, Padma Tirumalai, Geoffrey Adams, Tasneem A. Arsiwala, Olaf Blanke, James J. Mahoney III
Opioid use disorder remains a critical health care challenge because current therapeutic strategies have limitations that result in high recurrence and deaths. We evaluated the safety and feasibility of focused ultrasound (FUS) neuromodulation to reduce substance cravings and use in severe opioid and co-occurring substance use disorders.
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The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-09 Adrian Dahl Askelund, Laura Hegemann, Andrea G. Allegrini, Elizabeth C. Corfield, Helga Ask, Neil M. Davies, Ole A. Andreassen, Alexandra Havdahl, Laurie J. Hannigan
Early in life, behavioral and cognitive traits associated with risk for developing a psychiatric condition are broad and undifferentiated. As children develop, these traits differentiate into characteristic clusters of symptoms and behaviors that ultimately form the basis of diagnostic categories. Understanding this differentiation process—in the context of genetic risk for psychiatric conditions,
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The Dark Side of Empathy: The Role of Excessive Affective Empathy in Mental Health Disorders Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-09 Chaoli Huang, Zifeng Wu, Sha Sha, Cunming Liu, Ling Yang, Peng Jiang, Hongxing Zhang, Chun Yang
Empathy, which is typically regarded as a positive attribute, is now being critically evaluated for its potential negative implications for mental health. A growing body of research indicates that excessive empathy, particularly a high level of affective empathy, can lead to overwhelming emotional states, thereby increasing susceptibility to psychological distress and psychiatric disorders. In this
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One BAG Does Not Fit All: Differences and Similarities of BAG Family Members in Mediating Central Nervous System Homeostasis Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-08 Heng Lin, Sudarshan Ramanan, Sofia Kaplan, Darron H. King, Dominic Bunn, Gail V.W. Johnson
There is an increasing awareness that B-cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) proteins play critical roles in maintaining neural homeostasis and that their dysregulation contributes to neurological disorders. This protein family, which comprises 9 members, is evolutionarily conserved, with each member having at least one BAG domain that binds to the nucleotide-binding domains of Hsp70
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Early Risk Identification and Prevention of Bipolar Disorder: Ethical Considerations and User Perspectives Biol. Psychiatry (IF 9.6) Pub Date : 2025-01-02 Rudolf Uher, Alyson Zwicker
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Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-25 Randall J. Ellis, Jacqueline-Marie N. Ferland, Tanni Rahman, Joseph L. Landry, James E. Callens, Gaurav Pandey, TuKiet Lam, Jean Kanyo, Angus C. Nairn, Stella Dracheva, Yasmin L. Hurd
Identifying neurobiological targets predictive of the molecular neuropathophysiological signature of human opioid use disorder (OUD) could expedite new treatments. OUD is characterized by dysregulated cognition and goal-directed behavior mediated by the orbitofrontal cortex (OFC), and next-generation sequencing could provide insights regarding novel targets.
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Negative Valence in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-24 Nadza Dzinalija, Chris Vriend, Lea Waller, H. Blair Simpson, Iliyan Ivanov, Sri Mahavir Agarwal, Pino Alonso, Lea L. Backhausen, Srinivas Balachander, Aniek Broekhuizen, Miguel Castelo-Branco, Ana Daniela Costa, Hailun Cui, Damiaan Denys, Isabel Catarina Duarte, Goi Khia Eng, Susanne Erk, Sophie M.D.D. Fitzsimmons, Jonathan Ipser, Fern Jaspers-Fayer, Niels T. de Joode, Minah Kim, Kathrin Koch, Jun
Obsessive-compulsive disorder (OCD) is associated with altered brain function related to processing of negative emotions. To investigate neural correlates of negative valence in OCD, we pooled functional magnetic resonance imaging data of 633 individuals with OCD and 453 healthy control participants from 16 studies using different negatively valenced tasks across the ENIGMA (Enhancing Neuro Imaging
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Old Strategies, New Environments: Reinforcement Learning on Social Media Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-24 Georgia Turner, Amanda M. Ferguson, Tanay Katiyar, Stefano Palminteri, Amy Orben
The rise of social media has profoundly altered the social world, introducing new behaviors that can satisfy our social needs. However, it is not yet known whether human social strategies, which are well adapted to the offline world we developed in, operate as effectively within this new social environment. Here, we describe how the computational framework of reinforcement learning (RL) can help us
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A Multiform Heterogeneity Framework for Alzheimer’s Disease Based on Multimodal Neuroimaging Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-24 Kun Zhao, Pindong Chen, Dong Wang, Rongshen Zhou, Guolin Ma, Yong Liu
Understanding the heterogeneity of Alzheimer’s disease (AD) is crucial for advancing precision medicine specifically tailored to this disorder. Recent research has deepened our understanding of AD heterogeneity; however, translating these insights from bench to bedside via neuroimaging heterogeneity frameworks presents significant challenges. In this review, we systematically revisit prior studies
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Psychotropic Taxonomies: Constructing a Therapeutic Framework for Psychiatry Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-19 Robert A. McCutcheon, Philip Cowen, Matthew M. Nour, Toby Pillinger
Pharmacological interventions are a cornerstone of psychiatric practice. The taxonomies used to classify these interventions influence the treatment and interpretation of psychiatric symptoms. Disease-based classification systems (e.g., antidepressant and antipsychotic) do not reflect the fact that psychotropic agents are used across diagnostic categories or account for the dimensional nature of both
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Deep Brain Stimulation of the Nucleus Accumbens for Severe Self-Injurious Behavior in Children: A Phase I Pilot Trial Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-05 Carolina Gorodetsky, Karim Mithani, Sara Breitbart, Han Yan, Kristina Zhang, Flavia Venetucci Gouveia, Nebras Warsi, Hrishikesh Suresh, Simeon M. Wong, Joelene Huber, Elizabeth N. Kerr, Abhaya V. Kulkarni, Margot J. Taylor, Louis P. Hagopian, Alfonso Fasano, George M. Ibrahim
Self-injurious behavior (SIB) consists of repetitive, nonaccidental movements that result in physical damage inflicted upon oneself, without suicidal intent. SIB is prevalent among children with autism spectrum disorder and can lead to permanent disability or death. Neuromodulation at a locus of neural circuitry implicated in SIB, the nucleus accumbens (NAc), may directly influence these behaviors
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Copy Number Variations and Human Well-Being: Integrating Psychiatric, Physical, and Socioeconomic Perspectives Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-04 Itaru Kushima, Masahiro Nakatochi, Norio Ozaki
Copy number variations (CNVs) have emerged as crucial genetic factors that influence a wide spectrum of human health outcomes, with particularly strong associations to psychiatric disorders. In this review, we present a synthesis of diverse impacts of psychiatric disorder–associated CNVs on neurodevelopment, brain function, and physical health across the lifespan. Large-scale studies have revealed
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PsyRiskMR: A Comprehensive Resource for Identifying Psychiatric Disorder Risk Factors Through Mendelian Randomization Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-04 Xiaoyan Li, Aotian Shen, Lingli Fan, Yiran Zhao, Junfeng Xia
Psychiatric disorders pose an enormous economic and emotional burden on individuals, their families, and society. Given that the current analysis of the pathogenesis of psychiatric disorders remains challenging and time consuming, elucidating modifiable risk factors is crucial for the diagnosis and management of psychiatric disorders. However, inferring causal risk factors for these disorders from
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Variations in Brain Glutamate and Glutamine Levels Throughout the Sleep-Wake Cycle Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-04 Sujung Yoon, Suji Lee, Yoonji Joo, Eunji Ha, Haejin Hong, Yumi Song, Hyangwon Lee, Shinhye Kim, Chaewon Suh, C. Justin Lee, In Kyoon Lyoo
Glutamatergic signaling is essential for modulating synaptic plasticity and cognition. However, the dynamics of glutamatergic activity over the 24-hour sleep-wake cycle, particularly in relation to sleep, remain poorly understood. In this study, we aimed to investigate diurnal variations in brain Glx levels—representing the combined concentrations of glutamate and glutamine—in humans and to explore
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Data-Driven Analysis Identifies Novel Modulation of Social Behavior in Female Mice Witnessing Chronic Social Defeat Stress Biol. Psychiatry (IF 9.6) Pub Date : 2024-12-03 Heike Schuler, Rand S. Eid, Serena Wu, Yiu-Chung Tse, Vedrana Cvetkovska, Joëlle Lopez, Rosalie Quinn, Delong Zhou, Juliet Meccia, Laurence Dion-Albert, Shannon N. Bennett, Emily L. Newman, Brian C. Trainor, Catherine J. Peña, Caroline Menard, Rosemary C. Bagot
Chronic social defeat stress is a widely used depression model in male mice. Several proposed adaptations extend this model to females with variable, often marginal effects. We examined if the widely used male-defined metrics of stress are suboptimal in females witnessing defeat.