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Early use of intravitreal triamcinolone to inhibit traumatic proliferative vitreoretinopathy: a randomised clinical trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-28 Haixia Guo, Jinguo Yu, Tiangeng He, Song Chen, Zhuoyu Sun, Jingkai Zhang, Zhiyong Sun, Wenhui Yang, Baoqun Yao, Xueli Yang, Yuanyuan Liu, Mingxue Zhang, Yu Meng, Likun Yang, Hua Yan
Aims To evaluate the efficacy and safety of intravitreal triamcinolone acetonide (TA) injection at the end of emergency surgery for open globe injury (OGI) to suppress traumatic proliferative vitreoretinopathy (TPVR). Methods A single-centre, participant-masked, prospective, randomised controlled clinical trial. A total of 68 globe rupture patients with zone III were randomised to the control group
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Retinal detachment risk in the fellow eyes of patients presenting with retinal tears in more than two quadrants Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-28 Xiaoman Li, Arabella V Poulson, Martin P Snead
Literature discussing fellow eye risk in patients with rhegmatogenous retinal detachment secondary to posterior vitreous detachment (PVD) is limited, particularly in subgroups where this risk may be greater than the general population. In this retrospective consecutive case series with 107 study patients, the risk of retinal tears in fellow eyes of patients with horseshoe tears in three or more quadrants
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Age-matched analysis of axial length growth in myopic children wearing defocus incorporated multiple segments spectacle lenses Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-27 Birte Graff, Carly S Y Lam, Natalia Vlasak, Hakan Kaymak
Background/aims Defocus incorporated multiple segments (DIMS) spectacle lenses are known to be able to inhibit axial length (AL) growth in myopic children compared with single vision (SV) spectacle lenses. However, it is not known whether AL growth is sufficiently inhibited to achieve the treatment goal of physiological AL growth. Methods Of the data already collected in 2014–2017 by Lam et al , the
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Effects of orbital decompression on duction, cyclotorsion and diplopia Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-27 Hinke Marijke Jellema, Martina Althaus, Elly Merckel-Timmer, Dyonne T Hartong, Roel Kloos, Peerooz Saeed
Background Orbital decompression is commonly performed to correct proptosis in patients with Graves’ orbitopathy (GO). In literature, the incidence of new-onset constant diplopia after orbital decompression varies. Few studies have evaluated changes in duction and cyclodeviation after orbital decompression. We evaluated the changes in duction, cyclodeviation, eye position and degree of diplopia after
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Ocular inflammatory events following COVID-19 vaccination: reporting of suspected adverse drug reactions to regulatory authorities in the UK Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-27 Ilaria Testi, Taha Soomro, Carlos Pavesio, Ameenat Lola Solebo
Background/aims The UK Medicines and Healthcare products Regulatory Agency (MHRA) has published suspected adverse drug reactions to vaccines against COVID-19. Ocular inflammatory events following COVID-19 vaccination have been reported worldwide. Methods We analysed MHRA data on spontaneous reports of suspected ocular inflammatory events following COVID-19 vaccination between January 2021 and September
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Genomics enabling personalised glaucoma care Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-21 Kelsey V Stuart, Anthony P Khawaja
Glaucoma is a leading cause of visual impairment and a significant public health concern, but despite ongoing advances in our understanding of the disease, several important clinical challenges remain. With the number of affected people projected to increase substantially over coming decades, novel approaches to screening, risk stratification, therapy and glaucoma research are essential to deal with
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At a glance Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Frank Larkin
This population-based matched case-control study in Nepal evaluated risk factors for corneal ulcer. We found that ocular injury, manual labour, and lower education were associated with the development of corneal ulceration in this setting. The findings of this double-masked parallel randomised controlled trial comparing mini-simple limbal epithelial transplantation and conjunctival-limbal autograft
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Diabetic retinopathy screening: does one size fit all? Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Parul Desai, Samantha R De Silva
Health policy is constantly striving to release capacity in overstretched health services, or to improve effectiveness, efficiency and patient experience, while maintaining clinical safety. However, policy implementation may also introduce unintended consequences. This is elegantly highlighted in the paper by Olvera-Barrios et al 1 reporting a large retrospective study on the differential impact of
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Hypotony in uveitis: an overview of medical and surgical management Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Ilaria Testi, Antonio Calcagni, Keith Barton, James Gooch, Harry Petrushkin
Hypotony is a well-recognised, sight-threatening complication of uveitis. It can also be the final common endpoint for a multitude of disease entities. Multiple mechanisms underlie hypotony, and meticulous clinical history alongside ocular phenotyping is necessary for choosing the best intervention and therapeutic management. In this narrative review, a comprehensive overview of medical and surgical
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Risk factors for corneal ulcers: a population-based matched case–control study in Nepal Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Raghunandan Byanju, Ram Prasad Kandel, Bimal Poudyal, Sadhan Bhandari, Anju Ligal, Sangita Pradhan, Maria Gautam, Puspa Shrestha, Ranjeet Kumar Sah, John A Gonzales, Travis C Porco, John P Whitcher, Muthiah Srinivasan, Madan Prasad Upadhyay, Thomas M Lietman, Jeremy David Keenan, Kieran S O'Brien
Background/aims We aimed to examine risk factors for corneal ulcer in a rural and peri-urban setting in Nepal. Methods This population-based matched case–control study was nested in a cluster randomised trial in 24 village development committees in Nepal. Incidence density sampling was used to match incident corneal opacity cases to controls, matching on time of opacity, age, sex and location. Cases
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Comparison of mini-simple limbal epithelial transplantation and conjunctival–limbal autograft for the treatment of primary pterygium: a randomised controlled trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Valeria Oliva-Biénzobas, Angel Nava-Castañeda, Aida Jimenez-Corona, Nicolás Kahuam-López, Arturo Ramirez-Miranda, Alejandro Navas, Enrique O Graue-Hernandez
Purpose The purpose of this double-masked, parallel randomised controlled trial was to compare the recurrence rate and other outcomes between conjunctival–limbal autograft (CLAu) and mini-simple limbal epithelial transplantation (mini-SLET) after excision of pterygium. Methods Eligibility criteria for participants was the presence of a primary nasal pterygium extending equally to or greater than two
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Immediate sequential bilateral cataract surgery: a 13-year real-life report of 56 700 cataract operations Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Pekko Hujanen, Anu Vaajanen, Tuukka Felin, Eemil Lehtonen, Ulla Syvänen, Heini Huhtala, Mika Helminen, Harri Sintonen, Anja Tuulonen, Hannele Uusitalo-Järvinen
Background/aims To assess the frequency of immediate sequential bilateral cataract surgery (ISBCS) and endophthalmitis during 13-year period in Tays Eye Centre, Tampere University Hospital, Tampere, Finland. Methods All cataract surgeries performed between 1 January 2008 and 31 December 2020, and all endophthalmitis cases during the same period were searched from electronic patient records. Numbers
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Avoidable childhood blindness in a high-income country: findings from the British Childhood Visual Impairment and Blindness Study 2 Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Ameenat Lola Solebo, Lucinda Teoh, Jenefer Sargent, Jugnoo S Rahi
Background/aims Addressing childhood visual disability is an international priority, with data on causes needed to plan, implement and evaluate public health and clinical care. We have examined the contribution of ‘avoidable’ blinding disorders to childhood visual impairment, severe visual impairment and blindness (VI/SVIBL) in the UK. Methods National prospective observational longitudinal study,
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Modelling ready-made spectacle coverage for children and adults using a large global database Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Ving Fai Chan, David M Wright, Sonia Mavi, Reshma Dabideen, Mike Smith, Alan Sherif, Nathan Congdon
Background/aims To model the suitability of conventional ready-made spectacles (RMS) and interchangeable-lens ready-made spectacles (IRMS) with reference to prescribing guidelines among children and adults using a large, global database and to introduce a web-based application for exploring the database with user-defined eligibility criteria. Methods Using refractive power and interpupillary distance
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Prevalence of myopia and uncorrected myopia among 721 032 schoolchildren in a city-wide vision screening in southern China: the Shantou Myopia Study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Hongxi Wang, Yuancun Li, Kunliang Qiu, Riping Zhang, Xuehui Lu, Li Luo, Jian-Wei Lin, Yanlin Lu, Dan Zhang, Peiting Guo, Yong Yang, Liu Jing, Yingzi Huang, Qian Ma, Ruiqing Zhou, Yunxuan Ou, Quanwen Chen, Youming Zhou, Dandan Deng, Can Li, Jason C Yam, Li Jia Chen, Chi-Pui Pang, Mingzhi Zhang
Aims To explore the prevalence and risk factors for myopia and uncorrected myopia in schoolchildren in southern China. Methods The government-led Shantou Myopia Study was conducted from September 2020 to June 2021. Non-cycloplegic refraction was performed. Uncorrected visual acuity (UCVA) was measured along with presenting visual acuity if participants wore spectacles. Spherical equivalent refraction
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Effect of spectacle lenses with aspherical lenslets on choroidal thickness in myopic children: a 2-year randomised clinical trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Yingying Huang, Xue Li, Junqian Wu, Jiawen Huo, Fengchao Zhou, Jiali Zhang, Adeline Yang, Daniel P Spiegel, Hao Chen, Jinhua Bao
Objective Spectacle lenses with highly aspherical lenslets (HAL) and slightly aspherical lenslets (SAL) showed effective myopia control. This study was to investigate their effects on macular choroidal thickness (ChT) in myopic children. Methods Exploratory analysis from a 2-year, double-masked, randomised trial. 170 children aged 8–13 years with myopia between −0.75D and −4.75D, astigmatism of 1.50D
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Effect of atropine, orthokeratology and combined treatments for myopia control: a 2-year stratified randomised clinical trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Shengsong Xu, Zhouyue Li, Wenchen Zhao, Bingru Zheng, Jinyun Jiang, Guitong Ye, Zhibin Feng, Wen Long, Liying He, Mingguang He, Yin Hu, Xiao Yang
Purpose To investigate the 2-year efficacy of atropine, orthokeratology (ortho-k) and combined treatment on myopia. To explore the factors influencing the efficacy. Methods An age-stratified randomised controlled trial. Children (n=164) aged 8–12 years with spherical equivalent refraction of −1.00 to −6.00 D were stratified into two age subgroups and randomly assigned to receive placebo drops+spectacles
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Risk factors associated with abandonment of care in retinoblastoma: analysis of 692 patients from 10 countries Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Thamanna Nishath, Xiudi Li, Arthika Chandramohan, Megan Othus, Xunda Ji, Yihua Zou, Sadia Sultana, Riffat Rashid, Sadik Taju Sherief, Nathalie Cassoux, Juan Luis Garcia Leon, Rosdali Díaz Coronado, Arturo Manuel Zapata López, Tatiana L Ushakova, Vladimir G Polyakov, Soma Rani Roy, Alia Ahmad, Ashwin Reddy, Mandeep S Sagoo, Lamis Al Harby, Jonathan W Kim, Jesse L Berry, Ashley Polski, Nick Astbury,
Background Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients. Methods A prospective, observational study of 692 patients from 11 RB centres in 10 countries was
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Long-term surgical outcomes of Aurolab aqueous drainage implant in pediatric eyes with primary congenital glaucoma versus aphakic glaucoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 George Varghese Puthuran, Sujitha Ramesh, Peethala Maheswari, Madan Mohan Reddy, Mohammed Sithiq Uduman S, Subbaiah Ramasamy Krishnadas, Steven J Gedde
Purpose To compare the outcomes of the Aurolab aqueous drainage implant (AADI) placed in eyes with refractory primary congenital glaucoma (PCG) versus aphakic glaucoma (APG). Design Retrospective comparative interventional case series. Methods Case files of consecutive eyes with PCG or APG that underwent AADI surgery between January 2013 and December 2016 and had a minimum 4 years follow-up were extracted
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Association of macular vessel density and ganglion cell complex thickness with central visual field progression in glaucoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Jo-Hsuan Wu, Sasan Moghimi, Takashi Nishida, Golnoush Mahmoudinezhad, Linda M Zangwill, Robert N Weinreb
Background/aims To evaluate the association of macular vessel density (VD) and ganglion cell complex (GCC) thickness with 10–2 central visual field (CVF) progression in glaucoma. Methods In this retrospective cohort study, patients with glaucoma from Diagnostic Innovation in Glaucoma Study with≥five 10–2 visual field (VF) tests and 3-year follow-up before optical coherence tomography (OCT) and OCT
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Electroretinographic findings in retinal vasculitis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Hashem H Ghoraba, Wataru Matsumiya, Christopher Or, Hassan Khojasteh, Prem Patel, Irmak Karaca, Jonathan Regenold, Moosa Zaidi, Jaclyn Hwang, Sherin Lajevardi, Negin Yavari, Ngoc Trong Tuong Than, Sung Who Park, Amir Akhavanrezayat, Gunay Uludag, Cigdem Yasar, Loh-Shan B Leung, Quan Dong Nguyen
Aim To describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV). Methods Medical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded
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Two-year recall for people with no diabetic retinopathy: a multi-ethnic population-based retrospective cohort study using real-world data to quantify the effect Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Abraham Olvera-Barrios, Alicja R Rudnicka, John Anderson, Louis Bolter, Ryan Chambers, Alasdair N Warwick, Roshan Welikala, Jiri Fajtl, Sarah Barman, Paolo Remgnino, Yue Wu, Aaron Y Lee, Emily Y Chew, Frederick L Ferris, Aroon Hingorani, Reecha Sofat, Catherine A. Egan, Adnan Tufail, Christopher G Owen
Background/aims The English Diabetic Eye Screening Programme (DESP) offers people living with diabetes (PLD) annual screening. Less frequent screening has been advocated among PLD without diabetic retinopathy (DR), but evidence for each ethnic group is limited. We examined the potential effect of biennial versus annual screening on the detection of sight-threatening diabetic retinopathy (STDR) and
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Formal registration of visual impairment in people with diabetic retinopathy significantly underestimates the scale of the problem: a retrospective cohort study at a tertiary care eye hospital service in the UK Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Abraham Olvera-Barrios, Amit V Mishra, Roy Schwartz, Mumina Khatun, Michael Seltene, Celestine Rutkowska, Alicja R Rudnicka, Christopher G Owen, Adnan Tufail, Catherine A Egan
Aims To analyse the prevalence of visual impairment (VI), compare it to certification of visual impairment (CVI) and analyse VI associations in patients with diabetic retinopathy (DR). Methods Retrospective cohort study, which included 8007 patients with DR referred from the English diabetic eye screening programme to a tertiary referral eye hospital. Main outcome measure was VI, defined as vision
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Automatic interpretation and clinical evaluation for fundus fluorescein angiography images of diabetic retinopathy patients by deep learning Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Zhiyuan Gao, Xiangji Pan, Ji Shao, Xiaoyu Jiang, Zhaoan Su, Kai Jin, Juan Ye
Background/aims Fundus fluorescein angiography (FFA) is an important technique to evaluate diabetic retinopathy (DR) and other retinal diseases. The interpretation of FFA images is complex and time-consuming, and the ability of diagnosis is uneven among different ophthalmologists. The aim of the study is to develop a clinically usable multilevel classification deep learning model for FFA images, including
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Automated segmentation of ultra-widefield fluorescein angiography of diabetic retinopathy using deep learning Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Phil-Kyu Lee, Ho Ra, Jiwon Baek
Background/Aims Retinal capillary non-perfusion (NP) and neovascularisation (NV) are two of the most important angiographic changes in diabetic retinopathy (DR). This study investigated the feasibility of using deep learning (DL) models to automatically segment NP and NV on ultra-widefield fluorescein angiography (UWFA) images from patients with DR. Methods Retrospective cross-sectional chart review
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Macular thickness and its associated factors in a Chinese rural adult population: the Handan Eye Study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Jian Wu, Caixia Lin, Yifan Du, Su Jie Fan, Lijie Pan, Qing Pan, Kai Cao, Ningli Wang
Purpose To describe the normal macular thickness and assess its associations. Methods The Handan Eye Follow-up Study was conducted between 2012 and 2013. Macular thickness was scanned by spectral-domain optical coherence tomography (OCT). The built-in software generated a retinal thickness (RT) map, which was divided into three regions (central, internal and external regions) and nine quadrants (one
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Prevalence and risk factors for age-related macular degeneration in a population-based cohort study of older adults in Northern Ireland using multimodal imaging: NICOLA Study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Ruth E Hogg, David M Wright, Nicola B Quinn, Katherine Alyson Muldrew, Barbra Hamill, Laura Smyth, Amy Jayne McKnight, Jayne Woodside, Mark A Tully, Sharon Cruise, Bernadette McGuinness, Ian S Young, Frank Kee, Tunde Peto, Usha Chakravarthy
Purpose To report prevalence and risk factor associations for age-related macular degeneration (AMD) and AMD features from multimodal retinal grading in a multidisciplinary longitudinal population-based study of aging in Northern Ireland. Study design Population-based longitudinal cohort study. Methods Retinal imaging at the Norther Ireland Cohort for the Longitudinal Aging Study health assessment
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Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Matthias M Mauschitz, Timo Verzijden, Alexander K Schuster, Hisham Elbaz, Norbert Pfeiffer, Anthony Khawaja, Robert N Luben, Paul J Foster, Franziska G Rauscher, Kerstin Wirkner, Toralf Kirsten, Jost B Jonas, Mukharram M Bikbov, Ruth Hogg, Tunde Peto, Audrey Cougnard-Grégoire, Geir Bertelsen, Maja Gran Erke, Fotis Topouzis, Dimitrios A Giannoulis, Caroline Brandl, Iris M Heid, Catherine P Creuzot-Garcher
Background/aims To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. Methods We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any
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Characterising collateral vessels in eyes with branch retinal vein occlusions using widefield swept-source optical coherence tomography angiography Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Noam D Rudnick, Filippos Vingopoulos, Jay C Wang, Itika Garg, Ying Cui, Ying Zhu, Rongrong Le, Raviv Katz, Yifan Lu, Nimesh A Patel, John B Miller
Background/aims To characterise the morphology, location and functional significance of both macular and extramacular collateral vessels (CVs) in patients with a history of branch retinal vein occlusion (BRVO) using widefield swept-source optical coherence tomography angiography (WF SS OCTA). Methods Patients with a history of BRVO underwent WF SS OCTA testing to acquire 12×12 mm images, which were
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Impact of adalimumab in patients with active non-infectious intermediate, posterior, and panuveitis in real-life clinical practice: HOPE study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Uwe Pleyer, Salem Al-Mutairi, Conor C Murphy, Rola Hamam, Shereen Hammad, Orsolya Nagy, Zsuzsanna Szepessy, Yan Guex-Crosier, Karina Julian, Zohar Habot-Wilner, Sofia Androudi
Background/Aim This study evaluated real-life adalimumab impact in patients with active non-infectious intermediate, posterior, or panuveitis (NIIPPU). Methods Adults with active NIIPPU received adalimumab in this prospective, observational study (06/2017–04/2020). Patients were evaluated at baseline (V0) and four follow-up visits over 12 months (V1–V4). Primary endpoint: proportion of patients achieving
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Pupillotonia after endolaser retinopexy during vitrectomy for retinal detachment: a prospective cohort study comparing circumferential and focal retinopexy Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Christos Skevas, David Thiwa, Karl-Ulrich Bartz-Schmidt, Toam Katz, Martin Spitzer, Spyridon Dimopoulos
Purpose To determine differences in postoperative pupil diameter in eyes that undergo pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) with endolaser retinopexy (ELR), comparing 360° vs focal ELR. Methods Patients with uncomplicated RRD who underwent PPV were prospectively analysed regarding the postoperative pupil diameter difference (PDD) between the affected eye and the partner
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Association of hyperopia with incident clinically significant depression: epidemiological and genetic evidence in the middle-aged and older population Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Zijing Du, Xiayin Zhang, Yijun Hu, Yu Huang, Gabriella Bulloch, Xianwen Shang, Yingying Liang, Guanrong Wu, Yaxin Wang, Yu Xiao, Huiqian Kong, Dan Jouma Amadou Maman Lawali, Yunyan Hu, Zhuoting Zhu, Xiaohong Yang, Honghua Yu
Aims To investigate the association between hyperopia and clinically significant depression (CSD) in middle-aged and older individuals. The effect of genetic determinants of hyperopia on incident CSD was also explored. Methods We included participants who had available data on mean spherical equivalent (MSE) and were free of depression at baseline from the UK Biobank. For the phenotypic association
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Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Zhenyang Zhao, Steven Jay Frank, Jing Ning, Jiawei Zhao, Xinyang Jiang, Xin A Wang, Amy C Schefler, Ehab Hanna, Amy Moreno, Brandon Gunn, Renata Ferrarotto, Bita Esmaeli
Background We report visual outcomes and ocular complications in patients with lacrimal gland carcinoma who had eye-sparing surgery followed by radiotherapy. Methods This review included consecutive patients with lacrimal gland carcinoma who underwent eye-sparing surgery and adjuvant radiotherapy or concurrent chemoradiation therapy between 2007 and 2018. Clinical data, including details of ophthalmological
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Treatment outcomes and their determinants of IgG4-related ophthalmic disease: a territory-wide cohort study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Kenneth K H Lai, Emmy Y M Li, Regine Y C Chan, Winnie C W Chu, Andy C O Cheng, Karen K W Chan, Joyce K Y Chin, Jeremy S W Kwok, Ida Y F Io, Nelson K F Yip, Kenneth K W Li, Wai Ho Chan, Nai Man Lam, Wilson W K Yip, Alvin L Young, Edwin Chan, Callie K L Ko, Simon T C Ko, Hunter K L Yuen, Clement C Y Tham, Chi-Pui Pang, Kelvin K L Chong
Background Oral corticosteroid remains the first-line treatment of IgG4-related ophthalmic disease, but steroid-dependence is common and serious. Factors associated with steroid dependence and relapse have to be further explored. Study population A city-wide, biopsy-proven, Chinese cohort. Methods Retrospective, masked review of medical records, orbital images and histopathology reports. Results There
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Real-world clinical and molecular management of 50 prospective patients with microphthalmia, anophthalmia and/or ocular coloboma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Philippa Harding, Sri Gore, Samantha Malka, Jayashree Rajkumar, Ngozi Oluonye, Mariya Moosajee
Background/aims Microphthalmia, anophthalmia and coloboma (MAC) are clinically and genetically heterogenous rare developmental eye conditions, which contribute to a significant proportion of childhood blindness worldwide. Clear understanding of MAC aetiology and comorbidities is essential to providing patients with appropriate care. However, current management is unstandardised and molecular diagnostic
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Heteromeric formation with βA3 protects the low thermal stability of βB1-L116P Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-12-01 Jingjie Xu, Ying Zhang, Jian Liu, Lidan Hu, Chenqi Luo, Ke Yao, Xiangjun Chen
Background/aims Congenital cataract is the leading cause of visual disability and blindness in childhood. βB1-crystallin (CRYBB1) comprises about 1/10th of crystallin structural proteins, forming heteromers to maintain lens transparency. We previously reported a CRYBB1 mutation (c.347T>C, p.L116P) affecting 16 patients in a congenital nuclear cataract family. In this study, we investigate the underlying
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Anterior segment involvement in vitreoretinal lymphoma: clinical manifestations, molecular findings and in vivo confocal microscopy Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-14 Alessandro Marchese, Carlo Di Biase, Maria Vittoria Cicinelli, Matteo Menean, Giulio Ferrari, Francesco Bandello, Giulio Modorati, Debra Anne Goldstein, Elisabetta Miserocchi
Background Intermediate and posterior manifestations of vitreoretinal lymphoma (VRL) are well characterised. However, there is limited information on anterior segment involvement in VRL. This study aimed to describe the anterior manifestations of VRL, and their association with molecular testing. Methods Retrospective analysis of patients with biopsy-proven VRL. Study variables included anterior segment
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Bietti’s crystalline dystrophy: genotyping and deep qualitative and quantitative phenotyping in preparation for clinical trials Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-14 Qian Li, Cong Wang, Shengjuan Zhang, Zhongjie Fu, Xiaodong Jiao, Zi-Bing Jin, James Fielding Hejtmancik, Xiaoyan Peng
Purpose To qualitatively and quantitatively characterise the genotypes and phenotypes of Bietti’s crystalline dystrophy (BCD) in a cohort of patients. Design Cross-sectional and observational study. Methods Clinically confirmed BCD patients were recruited for genotyping and phenotyping. Multiple retinal imaging modalities were employed. Atrophy in the fovea was adopted as major consideration for staging
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Stargardt macular dystrophy and therapeutic approaches Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-08 Kaoru Fujinami, Nadia Waheed, Yannik Laich, Paul Yang, Yu Fujinami-Yokokawa, Joseph J Higgins, Jonathan T Lu, Darin Curtiss, Cathryn Clary, Michel Michaelides
Stargardt macular dystrophy (Stargardt disease; STGD1; OMIM 248200) is the most prevalent inherited macular dystrophy. STGD1 is an autosomal recessive disorder caused by multiple pathogenic sequence variants in the large ABCA4 gene (OMIM 601691). Major advances in understanding both the clinical and molecular features, as well as the underlying pathophysiology, have culminated in many completed, ongoing
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Performance of ChatGPT and Bard on the official part 1 FRCOphth practice questions Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-06 Thomas Fowler, Simon Pullen, Liam Birkett
Background Chat Generative Pre-trained Transformer (ChatGPT), a large language model by OpenAI, and Bard, Google’s artificial intelligence (AI) chatbot, have been evaluated in various contexts. This study aims to assess these models’ proficiency in the part 1 Fellowship of the Royal College of Ophthalmologists (FRCOphth) Multiple Choice Question (MCQ) examination, highlighting their potential in medical
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Capabilities of GPT-4 in ophthalmology: an analysis of model entropy and progress towards human-level medical question answering Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-03 Fares Antaki, Daniel Milad, Mark A Chia, Charles-Édouard Giguère, Samir Touma, Jonathan El-Khoury, Pearse A Keane, Renaud Duval
Background Evidence on the performance of Generative Pre-trained Transformer 4 (GPT-4), a large language model (LLM), in the ophthalmology question-answering domain is needed. Methods We tested GPT-4 on two 260-question multiple choice question sets from the Basic and Clinical Science Course (BCSC) Self-Assessment Program and the OphthoQuestions question banks. We compared the accuracy of GPT-4 models
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European Glaucoma Society research priorities for glaucoma care Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-03 Augusto Azuara-Blanco, Noleen McCorry, Andrew J Tatham, Stelios Georgoulas, Panayiota Founti, Cedric Schweitzer, Frances Meier-Gibbons, Philippe Denis, Anja Tuulonen, Gauti Johannesson, José María Martínez de la Casa, Verena Prokosch, Dimitrios A Giannoulis, Luis Abegão Pinto, David Garway-Heath, Fotis Topouzis
Background/Aims The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe. Methods We used a three-phase method, including a two-round electronic Delphi
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Deep-learning-based prediction of glaucoma conversion in normotensive glaucoma suspects Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-02 Ahnul Ha, Sukkyu Sun, Young Kook Kim, Jin Wook Jeoung, Hee Chan Kim, Ki Ho Park
Background/aims To assess the performance of deep-learning (DL) models for prediction of conversion to normal-tension glaucoma (NTG) in normotensive glaucoma suspect (GS) patients. Methods Datasets of 12 458 GS eyes were reviewed. Two hundred and ten eyes (105 eyes showing NTG conversion and 105 without conversion), followed up for a minimum of 7 years during which intraocular pressure (IOP) was lower
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Deep-learning automated quantification of longitudinal OCT scans demonstrates reduced RPE loss rate, preservation of intact macular area and predictive value of isolated photoreceptor degeneration in geographic atrophy patients receiving C3 inhibition treatment Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-02 Dun Jack Fu, Sophie Glinton, Veronika Lipkova, Livia Faes, Bart Liefers, Gongyu Zhang, Nikolas Pontikos, Alex McKeown, Lukas Scheibler, Praveen J Patel, Pearse A Keane, Konstantinos Balaskas
Objective To evaluate the role of automated optical coherence tomography (OCT) segmentation, using a validated deep-learning model, for assessing the effect of C3 inhibition on the area of geographic atrophy (GA); the constituent features of GA on OCT (photoreceptor degeneration (PRD), retinal pigment epithelium (RPE) loss and hypertransmission); and the area of unaffected healthy macula. To identify
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Strategic combination of cultivated oral mucosal epithelial transplantation and postoperative limbal-rigid contact lens-wear for end-stage ocular surface disease: a retrospective cohort study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-02 Yulia Aziza, Kojiro Imai, Motohiro Itoi, Hokoru Yoshioka, Seitaro Komai, Koji Kitazawa, Ratna Sitompul, Mayumi Ueta, Hideki Fukuoka, Tsutomu Inatomi, Shigeru Kinoshita, Chie Sotozono
Purpose To provide the long-term outcome of patients with end-stage severe ocular surface disease (OSD) consecutively treated with cultivated oral mucosal epithelial transplantation (COMET) followed by limbal-rigid contact lens (CL)-wear therapy. Design Retrospective cohort. Methods In 23 eyes of 18 patients with severe OSD who underwent COMET surgery between 2002 and 2019 and who were followed with
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Evaluation of a self-imaging OCT for remote diagnosis and monitoring of retinal diseases Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-30 Zitian Liu, Wenyong Huang, Zhenyu Wang, Ling Jin, Nathan Congdon, Yingfeng Zheng, Shida Chen, Yizhi Liu
Objectives To evaluate the feasibility and accuracy of a portable, self-imaging optical coherence tomography (OCT) for measuring central subfield thickness (CST) and achieving diagnostic concordance for retinal lesions compared with clinic-based spectral-domain OCT (SD-OCT). Methods This comparative, cross-sectional study was conducted between August 2020 and February 2021. Two groups of adult participants
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Long-term outcomes of deep anterior lamellar versus penetrating keratoplasty for keratoconus Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-27 Vincent Michel Borderie, Cristina Georgeon, Otman Sandali, N Bouheraoua
Aims To compare the long-term outcomes of deep anterior lamellar keratoplasty (DALK) with penetrating keratoplasty (PK) in keratoconus. Methods Retrospective comparative case series (228 DALKs and 274 PKs). A biphasic linear model was used to describe the postoperative outcome of the endothelial cell density (ECD). Visual acuity, specular microscopy, corneal topography and optical coherence tomography
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More support for deep anterior lamellar keratoplasty over penetrating keratoplasty for keratoconus, but questions remain Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-27 Uri S Soiberman, Albert S Jun
In this study, Borderie et al demonstrate long-term advantages of deep anterior lamellar keratoplasty (DALK) compared to penetrating keratoplasty (PK) in the treatment of keratoconus. In particular, they noted differences in long-term endothelial cell count and tendency to develop ocular hypertension favoring the DALK group. This is one of the largest studies on this topic; it provides long-term insight
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Outcomes of low-level light therapy before and after cataract surgery for the prophylaxis of postoperative dry eye: a prospective randomised double-masked controlled clinical trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-27 Giuseppe Giannaccare, Costanza Rossi, Massimiliano Borselli, Giovanna Carnovale Scalzo, Giovanni Scalia, Rocco Pietropaolo, Benedetta Fratto, Marco Pellegrini, Angeli Christy Yu, Vincenzo Scorcia
Background Despite increasing evidence shows that optimising ocular surface before cataract surgery is fundamental in patients with pre-existing dry eye disease (DED) to achieve the desired postoperative outcomes, the prophylactic treatment of healthy patients undergoing surgery aiming at preventing iatrogenic DED is worth investigating. Methods This was a prospective, interventional, randomised, controlled
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Time to treat the climate and nature crisis as one indivisible global health emergency Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-25 Chris Zielinski
Over 200 health journals call on the United Nations (UN), political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency. The world is currently responding to the climate crisis and
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Comparison of intestinal microbes and metabolites in active VKH versus acute anterior uveitis associated with ankylosing spondylitis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-19 Mengyao Li, Mingzhu Liu, Xia Wang, Haihui Wei, Siyan Jin, Xiaoli Liu
Background It has been reported that the gut microbiome is involved in the pathogenesis of uveitis, but the specific pathogenic microbes and metabolites in different types of uveitis are still unclear. Methods Microbiome and metabolites were detected using 16S ribosomal DNA and LC‒MS/MS (liquid chromatography tandem mass spectrometry) in 45 individuals, including 16 patients with Vogt Koyanagi Harada
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Variability of scan quality and perfusion density in longitudinal optical coherence tomography angiography imaging Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-19 Corey A Smith, Vanessa L Josey, Michael E West, Oksana M Dyachok, Glen P Sharpe, Jayme R Vianna, Paul E Rafuse, Lesya M Shuba, Marcelo T Nicolela, Balwantray C Chauhan
Background/aims Optical coherence tomography angiography (OCT-A) images are subject to variability, but the extent to which learning impacts OCT-A measurements is unknown. We determined whether there is a learning effect in glaucoma patients and healthy controls imaged with OCT-A. Methods Ninety-one open-angle glaucoma patients and 54 healthy controls were imaged every 4 months over a period of approximately
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Developing a privacy-preserving deep learning model for glaucoma detection: a multicentre study with federated learning Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-19 An Ran Ran, Xi Wang, Poemen P Chan, Mandy O M Wong, Hunter Yuen, Nai Man Lam, Noel C Y Chan, Wilson W K Yip, Alvin L Young, Hon-Wah Yung, Robert T Chang, Suria S Mannil, Yih-Chung Tham, Ching-Yu Cheng, Tien Yin Wong, Chi Pui Pang, Pheng-Ann Heng, Clement C Tham, Carol Y Cheung
Background Deep learning (DL) is promising to detect glaucoma. However, patients’ privacy and data security are major concerns when pooling all data for model development. We developed a privacy-preserving DL model using the federated learning (FL) paradigm to detect glaucoma from optical coherence tomography (OCT) images. Methods This is a multicentre study. The FL paradigm consisted of a ‘central
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Towards the validation of quantitative contrast sensitivity as a clinical endpoint: correlations with vision-related quality of life in bilateral AMD Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-19 Filippos Vingopoulos, Augustine Bannerman, Paul Zhou, Thomas Koch, Hannah E Wescott, Leo Kim, Demetrios Vavvas, Joan W Miller, John B Miller
Aim To investigate if active learning of contrast sensitivity (CS) in bilateral age-related macular degeneration (AMD) correlates better than visual acuity (VA) with vision-related quality of life (VRQoL) using factor analysis-calibrated National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25). Methods Prospective cross-sectional observational study in 93 patients (186 eyes) with bilateral
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Choroidal thickness in patients with thyroid-associated ophthalmopathy, as determined by swept-source optical coherence tomography Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-10-19 Sisi Zhong, Fanglin He, Sijie Fang, Jing Sun, Yinwei Li, Zhang Shuo, Xingtong Liu, Xuefei Song, Yang Wang, Yazhuo Huang, Huifang Zhou, Xianqun Fan
Aim This study used swept-source optical coherence tomography (SS-OCT) to investigate subfoveal choroidal thickness (SFCT) in patients with thyroid-associated ophthalmopathy (TAO) who displayed different levels of disease activity and severity. Methods Thirty patients with TAO (60 eyes) and 38 healthy controls (67 eyes) in Shanghai, China, were recruited for this study. Disease activity and severity
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At a glance Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-01 Frank Larkin
Baseline bilateral but not unilateral visual impairment (VI) conferred nearly two-fold higher odds of any incident fall. In those who had fallen at least once, it is of interest that having even mild unilateral VI conferred a substantially greater likelihood of further falls. Nationally representative cohort data showed that both pre-existing and new vision impairment increased all-cause mortality
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Visual loss in surgical retinal disease: retinal imaging and photoreceptor cell counts Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-01 Rodrigo Anguita, David Charteris
Vision loss after detachment of the neurosensory retina is a complex process which is not fully understood. Clinical factors have been identified which contribute to loss of macular function after retinal detachment and laboratory studies have played an important role in understanding the cellular and subcellular pathological processes which underlie the loss of visual function. As clinical imaging
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Associations between visual impairment, incident falls and fall frequency among older asians: longitudinal findings from the Singapore Epidemiology of Eye Diseases study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-01 Preeti Gupta, Ryan Eyn Kidd Man, Eva K Fenwick, Chaoxu Qian, Ralene Sim, Shivani Majithia, Yih Chung Tham, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, Ecosse Luc Lamoureux
Background Association between baseline visual impairment (VI) bilaterality and severity, and associated causes; and incident and frequent falls at 6 years in a multiethnic Asian population aged ≥60 years. Methods It is a population-based prospective cohort study. Visual acuity was clinically measured at both visits. Self-reported incidence and frequency of falls were defined as having no fall at baseline
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Longitudinal associations between self-reported vision impairment and all-cause mortality: a nationally representative cohort study among older Chinese adults Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-01 Ziyue Wang, Nathan Congdon, Xiaochen Ma
Objective To compare the effects of pre-existing and new self-reported vision impairment (VI), and its correction, on all-cause mortality among Chinese adults aged 45 years and older. Methods We used four waves of data from the China Health and Retirement Longitudinal Study. Our analytical cohort consists of 15 808 participants aged 45 years and older with an average follow-up of 6.4 years. Exposures
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Relationship between dry eye symptoms and quality of life: associations and mediation analysis Br. J. Ophthalmol. (IF 4.1) Pub Date : 2023-11-01 Elizabeth Wen Ling Lim, Crystal Chun Yuen Chong, Simon Nusinovici, Eva Fenwick, Ecosse Luc Lamoureux, Charumathi Sabanayagam, Ching-Yu Cheng, Louis Tong
Purpose (1) To determine the independent association of dry eye symptoms with health-related quality of life (HRQoL) in the Singapore population and (2) to further investigate which factors mediate this association. Methods In this cross-sectional study, 7707 participants were included. The presence of dry eye symptoms was defined as experiencing at least one out of the six symptoms either ‘often’