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Persistent subfoveal fluid in pneumatic retinopexy versus pars plana vitrectomy for rhegmatogenous retinal detachment: posthoc analysis of the PIVOT randomised trial Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-11 Aditya Bansal, Wei Wei Lee, David Sarraf, SriniVas R. Sadda, Alan R Berger, David T Wong, Peter J. Kertes, Radha P. Kohly, Roxane Jo Hillier, Rajeev H. Muni
Purpose To assess the incidence of persistent subfoveal fluid (PSFF) in pneumatic retinopexy (PnR) versus pars plana vitrectomy (PPV) following rhegmatogenous retinal detachment (RRD) repair and to determine its association with functional outcomes. Methods Posthoc analysis of the PIVOT randomised trial. Eyes with gradable en face and cross-sectional spectral-domain optical coherence tomography (SD-OCT)
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Hand grip strength and ocular associations: the Ural Eye and Medical Study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-11 Mukharram M Bikbov, Rinat M Zainullin, Timur R Gilmanshin, Ellina M Iakupova, Gyulli M Kazakbaeva, Songhomitra Panda-Jonas, Azaliia M Tuliakova, Albina A Fakhretdinova, Leisan I Gilemzianova, Jost B Jonas
Purpose To explore the associations between hand grip strength (HGS) and ocular parameters and diseases. Design Population-based cohort study. Methods Participants of the Ural Eye and Medical Study, including 5899 (80.5%) out of 7328 eligible individuals aged 40+ years, underwent systemic and ophthalmological examinations including dynamometric HGS measurement. Results The study included 5381 (90.4%)
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Choriocapillaris flow deficit and the risk of referable diabetic retinopathy: a longitudinal SS-OCTA study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-09 Wei Wang, Weijing Cheng, Shaopeng Yang, Yifan Chen, Zhuoting Zhu, Wenyong Huang
Aims To investigate the association between the choriocapillaris flow deficit percentage (CC FD%) and the 1-year incidence of referable diabetic retinopathy (RDR) in participants with type 2 diabetes mellitus (DM). Methods This prospective cohort study included participants with type 2 DM. The DR status was graded based on the ETDRS-7 photography. The CC FD% in the central 1 mm area, inner circle (1
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Relationship between dry eye symptoms and quality of life: associations and mediation analysis Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-08 Elizabeth Wen Ling Lim, Crystal Chun Yuen Chong, Simon Nusinovici, Eva Fenwick, Ecosse Luc Lamoureux, Charumathi Sabanayagam, Ching-Yu Cheng, Louis Tong
Purpose (1) To determine the independent association of dry eye symptoms with health-related quality of life (HRQoL) in the Singapore population and (2) to further investigate which factors mediate this association. Methods In this cross-sectional study, 7707 participants were included. The presence of dry eye symptoms was defined as experiencing at least one out of the six symptoms either ‘often’
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Association of baseline optical coherence tomography angiography with the development of glaucomatous visual field defects in preperimetric glaucoma eyes Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-05 Jin Yeong Lee, Joong Won Shin, Anna Lee, Min Su Baek, Michael S Kook
Aims To evaluate whether baseline vessel density (VD) parameters derived from optical coherence tomography angiography (OCT-A) is associated with the development of glaucomatous visual field (VF) defects in preperimetric glaucoma (PPG) patients. Methods One eye from each of 200 consecutive PPG patients with a normal standard automated perimetry and OCT-A at baseline was retrospectively analysed. OCT-A
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Deep learning model to identify homonymous defects on automated perimetry Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-03 Aaron Hao Tan, Laura Donaldson, Luqmaan Moolla, Austin Pereira, Edward Margolin
Background Homonymous visual field (VF) defects are usually an indicator of serious intracranial pathology but may be subtle and difficult to detect. Artificial intelligence (AI) models could play a key role in simplifying the detection of these defects. This study aimed to develop an automated deep learning AI model to accurately identify homonymous VF defects from automated perimetry. Methods VFs
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Risks of posterior segment ocular ischaemic events in patients with systemic lupus erythematosus: a population-based cohort study in Taiwan Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-03 Yi-Ran Chiou, Yu-Sheng Chang, Chin-Fang Su, Tzu-Hao Li, Chien-Chih Lai, De-Kuang Hwang, Fang-Yi Wu, Yu-Fan Chang
Backgroud/Aim Ocular involvement in systemic lupus erythematosus (SLE) is often primarily recognised by ophthalmologists rather than internists. This study aims to investigate the incidence and risk factors for the occurrence of posterior ocular ischaemic events (OIE), including retinal vein occlusion (RVO), retinal artery occlusion (RAO) and ischaemic optic neuropathy (ION), in patients with SLE.
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Associations between visual impairment, incident falls and fall frequency among older asians: longitudinal findings from the Singapore Epidemiology of Eye Diseases study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Preeti Gupta, Ryan Eyn Kidd Man, Eva K Fenwick, Chaoxu Qian, Ralene Sim, Shivani Majithia, Yih Chung Tham, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, Ecosse Luc Lamoureux
Background Association between baseline visual impairment (VI) bilaterality and severity, and associated causes; and incident and frequent falls at 6 years in a multiethnic Asian population aged ≥60 years. Methods It is a population-based prospective cohort study. Visual acuity was clinically measured at both visits. Self-reported incidence and frequency of falls were defined as having no fall at baseline
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Predicting the risk of distant and local recurrence for patients with ocular adnexal extranodal marginal zone lymphoma: a matched case–control study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Jiahao Shi, Tianyu Zhu, Min Zhou, Xiaowen Zhou, Xin Song, Yefei Wang, Renbing Jia, Ziyao Yu, Yixiong Zhou, Xianqun Fan
Background/aims Extranodal marginal zone lymphoma of ocular adnexa (OA-EMZL) is the most frequent type of ocular adnexal lymphomas, with a high rate of disease recurrence. Precise patient stratification based on disease recurrence is understudied. This study aims to identify risk factors of distant recurrence (DR) and local recurrence (LR) to construct a prognostic model optimising rapid decision of
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Prediction of visual impairment in retinitis pigmentosa using deep learning and multimodal fundus images Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-27 Tin Yan Alvin Liu, Carlthan Ling, Leo Hahn, Craig K Jones, Camiel JF Boon, Mandeep S Singh
Background The efficiency of clinical trials for retinitis pigmentosa (RP) treatment is limited by the screening burden and lack of reliable surrogate markers for functional end points. Automated methods to determine visual acuity (VA) may help address these challenges. We aimed to determine if VA could be estimated using confocal scanning laser ophthalmoscopy (cSLO) imaging and deep learning (DL)
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Role of corneal radius of curvature in early identification of fundus tessellation in children with low myopia Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-26 Wei Gong, Tianyu Cheng, Jingjing Wang, Bo Zhang, Jun Chen, Jianfeng Zhu, Haidong Zou, Kun Liu, Xiangui He, Xun Xu
Aim To assess the role of the corneal radius of curvature (CR) in the identification of fundus tessellation in children with low myopia. Methods In the cross-sectional study, students aged 9–12 years from 24 primary schools in Shanghai were enrolled by cluster sampling. Participants underwent measurements including cycloplegic refraction and axial length. Fundus images and choroidal thickness were
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Clinical course and treatment of archipelago keratitis: a Herpesviridae keratitis subtype Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-26 Damien Guindolet, Anna Gemahling, Antoine Rousseau, Pauline Nguyen Kim, Georges Azar, Gilles C Martin, Isabelle Cochereau, Marc Labetoulle, Eric E Gabison
Purpose Archipelago keratitis (ApK) is a subtype of Herpesviridae stromal keratitis that consists of subepithelial nummular inflammatory infiltrates arranged in a radial centripetal pattern. This rare and poorly described form is not often recognised early. We report the first large series of ApK, with an analysis of clinical settings at presentation, evolution of the disease with time and a description
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Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-26 Ashleigh Kernohan, Tara Homer, Hosein Shabaninejad, Anthony J King, Jemma Hudson, Gordon Fernie, Augusto Azuara-Blanco, Jennifer Burr, John M Sparrow, David Garway-Heath, Keith Barton, John Norrie, Graeme Maclennan, Luke Vale
Synopsis Advanced glaucoma is associated with sight loss. This within-trial economic evaluation compares medical and surgical management strategies. At 2 years, medication appears more cost-effective though longitudinal outcomes are an important subject in future research. Background/aims Open angle glaucoma (OAG) is a progressive optic neuropathy. Approximately 25% of newly diagnosed patients with
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Factors associated with choroidal microvascular dropout change Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-21 Eleonora Micheletti, Sasan Moghimi, Takashi Nishida, Nevin El-Nimri, Golnoush Mahmoudinedzah, Alireza Kamalipour, Vahid Mohammadzadeh, Linda M Zangwill, Robert N Weinreb
Background/aims To investigate the factors associated with choroidal microvasculature drop-out (MvD) enlargement detected by optical coherence tomography angiography (OCT-A) in glaucomatous eyes. Methods Ninety-one eyes of 68 primary open-angle glaucoma patients were enrolled. Only eyes with a minimum of four good quality OCT-A and OCT scans of the optic nerve head acquired at least and with a minimum
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Highlights from this issue Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Frank Larkin
Propensity score analysis of eyes with rhegmatogenous retinal detachment showed that postoperative vision was worse in eyes treated once with silicone oil than with gas, even after completely successful surgery. Prediction models developed to determine the risk of progression to referable diabetic retinopathy were tested in an Irish cohort of people with type 2 diabetes; found to perform similarly
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Could real-world data replace evidence from clinical trials in surgical retinal conditions? Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Rodrigo Anguita, David Charteris
Vitreoretinal surgeons have a range of procedures available to treat primary rhegmatogenous retinal detachment (RD) and decisions on which approach to take relate to the training and skill set of the individual surgeon and their assessment of the published literature. Randomised controlled trials (RCT) are uncommon in the surgical management of RD and most published work is on smaller, often retrospective
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Neuropathic corneal pain and dry eye: a continuum of nociception Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Gabriela Dieckmann, David Borsook, Eric Moulton
Throughout the body, damage to peripheral nerves normally involved in nociception may produce a constellation of symptoms—including irritation, itchiness and pain. The neurobiological processes involved in corneal symptoms of dry eye (DE) and neuropathic corneal pain (NCP) have not been clearly considered in terms of nociceptive processing. The conventional underlying presumption is that a labelled
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Silicone oil versus gas tamponade for primary rhegmatogenous retinal detachment treated successfully with a propensity score analysis: Japan Retinal Detachment Registry Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Ryoh Funatsu, Hiroto Terasaki, Chihaya Koriyama, Toshifumi Yamashita, Hideki Shiihara, Taiji Sakamoto
Background/aims To compare the effects of silicone oil tamponade (SOT) to that of gas tamponade (GT) on the best-corrected visual acuity (BCVA) after successful vitrectomy for retinal detachment (RD). Methods A retrospective, multicentre, nationwide study with RD who were registered in the Japan-RD Registry. All cases with RD treated with successful vitrectomy between February 2016 and March 2017 were
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Testing the performance of risk prediction models to determine progression to referable diabetic retinopathy in an Irish type 2 diabetes cohort Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 John J Smith, David M Wright, Irene M Stratton, Peter Henry Scanlon, Noemi Lois
Background /Aims To evaluate the performance of existing prediction models to determine risk of progression to referable diabetic retinopathy (RDR) using data from a prospective Irish cohort of people with type 2 diabetes (T2D). Methods A cohort of 939 people with T2D followed prospectively was used to test the performance of risk prediction models developed in Gloucester, UK, and Iceland. Observed
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Epidemiological characteristics and clinical course of eyelid squamous cell carcinoma patients from a large tertiary centre between 2009 and 2020 Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Annemarie Klingenstein, Christina Samel, Elisabeth M Messmer, Aylin Garip-Kuebler, Siegfried G Priglinger, Christoph R Hintschich
Background/aims To assess epidemiological tumour features, risk factors, clinical management and outcome of eyelid squamous cell carcinoma (SCC) and changes thereof. Furthermore, we searched for validating predictors of the American Joint Committee on Cancer (AJCC) 8 classification system. Methods We evaluated data of 117 patients with histologically proven eyelid SCC at a large tertiary German university
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Impact of incident age-related macular degeneration and associated vision loss on vision-related quality of life Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Ryan Eyn Kidd Man, Alfred Tau Liang Gan, Eva K Fenwick, Kelvin Yi Chong Teo, Anna C S Tan, Gemmy Chui Ming Cheung, Zhen Ling Teo, Neelam Kumari, Tien Yin Wong, Ching-Yu Cheng, Ecosse Luc Lamoureux
Background We examined the associations between the 6-year incidence of age-related macular degeneration (AMD) and vision-related quality of life (VRQoL), and the contribution of presenting visual acuity (VA), in an Asian population. Methods Fundus images from the Singapore Chinese Eye Study, a population-based cohort study (baseline: 2009–2011; follow-up: 2015–2017), were graded using a modified Wisconsin
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Two-year add-on effect of using low concentration atropine in poor responders of orthokeratology in myopic children Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Zhi Chen, Jiaqi Zhou, Feng Xue, Xiaomei Qu, Xingtao Zhou
Methods Axial elongation in 73 eyes of 73 subjects who completed 3 years of orthokeratology (ortho-k) treatment was retrospectively reviewed. During their first year of ortho-k treatment (phase 1), they all demonstrated an axial elongation of 0.30 mm or greater. They were then divided into two groups: orthokeratology and atropine (OKA) group (n=37) being treated with nightly 0.01% atropine in addition
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Morphological features and prognostic significance of multilayered pigment epithelium detachment in age-related macular degeneration Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Inhye Kim, Gahyung Ryu, Min Sagong
Aims To investigate the structure of multilayered pigment epithelial detachment (m-PED) in neovascular age-related macular degeneration, and its association with visual prognosis and the progression of fibrotic scars at 12 months. Methods We retrospectively analysed 68 eyes of 63 patients with m-PED that included a prechoroidal cleft. The compartments within m-PED were divided into neovascular tissue
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Development and evaluation of a deep learning model for the detection of multiple fundus diseases based on colour fundus photography Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Bing Li, Huan Chen, Bilei Zhang, Mingzhen Yuan, Xuemin Jin, Bo Lei, Jie Xu, Wei Gu, David Chuen Soong Wong, Xixi He, Hao Wang, Dayong Ding, Xirong Li, Youxin Chen, Weihong Yu
Aim To explore and evaluate an appropriate deep learning system (DLS) for the detection of 12 major fundus diseases using colour fundus photography. Methods Diagnostic performance of a DLS was tested on the detection of normal fundus and 12 major fundus diseases including referable diabetic retinopathy, pathologic myopic retinal degeneration, retinal vein occlusion, retinitis pigmentosa, retinal detachment
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Real-world experience of using ciclosporin-A 0.1% in the management of ocular surface inflammatory diseases Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Rashmi Deshmukh, Darren Shu Jeng Ting, Ahmad Elsahn, Imran Mohammed, Dalia G Said, Harminder Singh Dua
Purpose To report the real-world experience of using topical ciclosporin, Ikervis, in the management of ocular surface inflammatory diseases (OSIDs). Methods This was a retrospective study of patients treated with Ikervis for OSIDs at the Queen’s Medical Centre, Nottingham, between 2016 and 2019. Relevant data, including demographics, indications, clinical parameters, outcomes and adverse events, were
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Incidence of rhegmatogenous retinal detachment in France from 2010 to 2016: seasonal and geographical variations Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Inès Ben Ghezala, Anne Sophie Mariet, Eric Benzenine, Pierre-Henry Gabrielle, Florian Baudin, Alain M Bron, Catherine Quantin, Catherine P Creuzot-Garcher
Aims To investigate the annual and monthly hospital incidence rate of rhegmatogenous retinal detachments (RRDs) from 2010 to 2016 in France at the national and regional levels. Methods In this nationwide database study, we identified hospital and clinic admissions of French residents for a first episode of RRD in France during 2010–2016 from the national administrative database. The annual and monthly
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Investigating the clinical usefulness of definitions of progression with 10-2 visual field Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Shotaro Asano, Hiroshi Murata, Yuri Fujino, Takehiro Yamashita, Atsuya Miki, Yoko Ikeda, Kazuhiko Mori, Masaki Tanito, Ryo Asaoka
Background/Aim To investigate the clinical validity of the Guided Progression Analysis definition (GPAD) and cluster-based definition (CBD) with the Humphrey Field Analyzer 10-2 test in diagnosing glaucomatous visual field (VF) progression, and to introduce a novel definition with optimised specificity by combining the ‘any-location’ and ‘cluster-based’ approaches (hybrid definition). Methods 64 400
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Progression of myopia in children and teenagers: a nationwide longitudinal study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Dorian Tricard, Simon Marillet, Pierre Ingrand, Mark A Bullimore, Rupert R A Bourne, Nicolas Leveziel
Background Data on myopia prevalence and progression in European children are sparse. The aim of this work was to evaluate the progression of myopia in children and teenagers in a large prospective study. Methods A prospective study involving a nationwide cohort. Myopia was defined as a spherical equivalent (SE) of ≤ –0.50 diopters (D). Data on refractive error, gender and age were collected in 696
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Myopia control effect of defocus incorporated multiple segments (DIMS) spectacle lens in Chinese children: results of a 3-year follow-up study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Carly SY Lam, Wing Chun Tang, Paul H Lee, Han Yu Zhang, Hua Qi, Keigo Hasegawa, Chi Ho To
Aims To determine myopia progression in children who continued to wear the defocus incorporated multiple segments (DIMS) lenses or switched from single vision (SV) to DIMS lenses for a 1-year period following a 2-year myopia control trial. Methods 128 children participated in this study. The children who had worn DIMS lenses continued to wear DIMS lenses (DIMS group), and children who had worn SV lenses
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Longitudinal visual field variability and the ability to detect glaucoma progression in black and white individuals Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Brian Stagg, Eduardo B Mariottoni, Samuel Berchuck, Alessandro Jammal, Angela R Elam, Rachel Hess, Kensaku Kawamoto, Benjamin Haaland, Felipe A Medeiros
Background/Aims To investigate racial differences in the variability of longitudinal visual field testing in a ‘real-world’ clinical population, evaluate how these differences are influenced by socioeconomic status, and estimate the impact of differences in variability on the time to detect visual field progression. Methods This retrospective observational cohort study used data from 1103 eyes from
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Prevalence of glaucoma in the Lao People’s Democratic Republic: the Vientiane Eye Study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Brad Guo, Yiran Tan, Stephen Nygaard, Cesar Carrillo, Kham Od Nouansavanh, Kitar Souksamone, Robert J Casson
Aims To determine the prevalence and subtypes of glaucoma in Vientiane Province. Methods We conducted a population-based study of 1264 participants aged ≥40 years of age from urban and rural areas of Vientiane Province. Data collection included Snellen visual acuity, slip lamp examination, tonometry, gonioscopy, dilated stereoscopic disc examination and perimetry. Glaucoma was categorised by clinical
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Retinal vascular bed area on ultra-wide field fluorescein angiography indicates the severity of diabetic retinopathy Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Wenying Fan, Akihito Uji, Muneeswar Nittala, Charles Clifton Wykoff, David Brown, Alan Fleming, Gavin Robertson, Jano van Hemert, SriniVas Sadda, Michael S Ip
Aims To quantify retinal vascular bed area (RVBA) in square millimetres on stereographically projected ultra-wide field (UWF) fluorescein angiography (FA) in eyes with diabetic retinopathy (DR). Methods A prospective, observational study. Baseline Optos 200Tx UWF FA images of 80 eyes with DR from the DAVE ([NCT01552408][1]) and RECOVERY ([NCT02863354][2]) studies were stereographically projected at
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Three-year OCT predictive factors of disease recurrence in eyes with successfully treated myopic choroidal neovascularisation Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Enrico Borrelli, Marco Battista, Giovanna Vella, Riccardo Sacconi, Lea Querques, Domenico Grosso, Francesco Bandello, Giuseppe Querques
Purpose To assess the relationship of demographics, clinical characteristics and structural optical coherence tomography (OCT) findings to disease recurrence in a cohort of patients with newly diagnosed myopic choroidal neovascularisation (CNV) Methods In this retrospective, longitudinal study, a total of 64 participants (64 eyes) with successfully treated myopic CNV had obtained resolution of exudation
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Extension study of the safety and efficacy of CLS-TA for treatment of macular oedema associated with non-infectious uveitis (MAGNOLIA) Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Rahul N Khurana, Pauline Merrill, Steven Yeh, Eric Suhler, Mark R Barakat, Eduardo Uchiyama, Christopher Ryan Henry, Milan Shah, Robert C Wang, Barry Kapik, Thomas Ciulla
Purpose To assess the extended efficacy and safety of suprachoroidal triamcinolone acetonide injectable suspension (CLS-TA) among patients with macular oedema (ME) secondary to non-infectious uveitis (NIU). Methods Patients with uveitic ME were treated with suprachoroidal CLS-TA at baseline and week 12 of the Efficacy and Safety of Suprachoroidal CLS-TA for Macular Edema Secondary to Noninfectious
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Better visual outcome associated with early vitrectomy in the management of endophthalmitis Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Sarah Welch, Riyaz Bhikoo, Nancy Wang, Martin J Siemerink, William Shew, Philip J Polkinghorne, Rachael L Niederer
Aims To examine the role of early vitrectomy in the management of endophthalmitis from all causes. Methods Retrospective study of 290 consecutive subjects diagnosed with endophthalmitis at Auckland District Health Board between 1 January 2006 and 31 July 2019. Main outcome measure was visual acuity at 9-month follow-up and proportion of subjects with severe vision loss (≤20/200). Results Median age
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Predicting the safety zone for steroid-induced ocular hypertension induced by intravitreal dexamethasone implantation Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Wungrak Choi, Hyoung Won Bae, Hye Jung Shin, Eun Woo Kim, Chan Yun Kim, Min Kim, Gong Je Seong
Background/aims This study aimed to predict the possibility of steroid-induced ocular hypertension (OHT) after intravitreal dexamethasone (DEX) implantation and to identify a proper safety zone for such injections. Methods A cross-sectional observational study was conducted and included 908 patient eyes that underwent DEX implant injection due to various retinal diseases. Intraocular pressure (IOP)
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Reliability of telemedicine for real-time paediatric ophthalmology consultations Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Carly Stewart, Josephine Coffey-Sandoval, Mark W Reid, Tiffany C Ho, Thomas C Lee, Sudha Nallasamy
Background/aims To assess the accuracy of real-time telemedicine to diagnose and manage paediatric eye conditions. Methods Design: Prospective, non-inferiority study analysing agreement in diagnoses and management plans between telemedicine and in-person examinations. Setting: Paediatric ophthalmology clinic. Population: Children 0–17 years, English-speaking or Spanish-speaking, able to participate
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Foveal structure and visual function in nanophthalmos and posterior microphthalmos Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Philipp L Müller, Tim Treis, Abdulrahman Alsaedi, Andrew R Webster, Peng Khaw, Michel Michaelides, Louisa Wickham, Dilani Siriwardena, Paul Foster, Mariya Moosajee, Carlos Pavesio, Adnan Tufail, Catherine Egan
Background/aims The reason for visual impairment in patients with nanophthalmos and posterior microphthalmos is not completely understood. Therefore, this study aims to investigate foveal structure, and the impact of demographic, clinical and imaging parameters on best-corrected visual acuity (BCVA) in these conditions. Methods Sixty-two eyes of 33 patients with nanophthalmos (n=40) or posterior microphthalmos
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One-year myopia control efficacy of spectacle lenses with aspherical lenslets Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Jinhua Bao, Adeline Yang, Yingying Huang, Xue Li, Yiguo Pan, Chenglu Ding, Ee Woon Lim, Jingwei Zheng, Daniel P Spiegel, Björn Drobe, Fan Lu, Hao Chen
Aims To evaluate the 1-year efficacy of two new myopia control spectacle lenses with lenslets of different asphericity. Methods One hundred seventy schoolchildren aged 8–13 years with myopia of −0.75 D to −4.75 D were randomised to receive spectacle lenses with highly aspherical lenslets (HAL), spectacle lenses with slightly aspherical lenslets (SAL), or single-vision spectacle lenses (SVL). Cycloplegic
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Twelve-month outcomes of ranibizumab versus aflibercept for macular oedema in branch retinal vein occlusion: data from the FRB! registry Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 Adrian R Hunt, Vuong Nguyen, Catherine P Creuzot-Garcher, Socorro Alforja, Pierre-Henry Gabrielle, Javier Zarranz-Ventura, Martin Guillemin, Samantha Fraser-Bell, Ricardo P Casaroli Marano, Jennifer Arnold, Ian L McAllister, Louise O'Toole, Mark C Gillies, Daniel Barthelmes, Hemal Mehta
Background/Aims To compare the efficacy of ranibizumab (0.5 mg) with aflibercept (2 mg) in the treatment of cystoid macular oedema due to branch retinal vein occlusion (BRVO) over 12 months. Methods A multicentre, international, database observational study recruited 322 eyes initiating therapy in real-world practice over 5 years. The main outcome measure was mean change in EDTRS letter scores of visual
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Correction: Corneal transplantation in the aftermath of the COVID-19 pandemic: an international perspective Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-08-01 BMJ Publishing Group Ltd.BMA House, Tavistock Square, London, WC1H 9JR
Ang M, Moriyama A, Colby K, et al . Corneal transplantation in the aftermath of the COVID-19 pandemic: an …
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Importance of subfoveal fluid height on visual outcome in macula-off retinal detachments Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-19 Carmen Baumann, Ahmed Almarzooqi, Navid Johannigmann-Malek, Mathias Maier, Stephen Kaye
Aims To investigate the effect of subfoveal fluid height (SFFH) on visual outcome after macula-off retinal detachment (RD) repair. Methods Prospective interventional case series of consecutive patients undergoing pars plana vitrectomy with gas tamponade (PPV) for primary macula-off RD with duration of symptomatic loss of central vision (LCV) of ≤1 week. Preoperative SFFH was measured on two occasions
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Incidence, progression and regression of diabetic retinopathy in a northeastern Chinese population Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-19 Zhong Lin, Liang Wen, Yu Wang, Dong Li, Gang Zhai, Nived Moonasar, Fenghua Wang, Yuanbo Liang
Aim To determine the incidence, progression and regression of diabetic retinopathy (DR), with corresponding risk factors, in a northeastern Chinese population of patients with type 2 diabetes. Methods Among 2006 patients who completed baseline examinations in 2012–2013 and underwent re-examination after a mean interval of 21.2 months, 1392 patients with gradable fundus photographs for both baseline
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Glaucoma in rural China (the Rural Epidemiology for Glaucoma in China (REG-China)): a national cross-sectional study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-15 Yuanyuan Liu, Baoqun Yao, Xi Chen, Xueli Yang, Yong Liu, Zhenggao Xie, Xiaofeng Chen, Zhigang Yuan, Xingrong Wang, Dan Hu, Xiang Ma, Weiqi Gao, Ruifeng Wang, Yuzhong Yang, Song Chen, Jingkai Zhang, Zuoqing Song, Junsu Wang, Jing Wang, Jinyun Pei, Weijuan Wang, Meiyan Wang, Jun Gao, Hongwen Zhang, Lian Tan, Wei Du, Xuehui Pan, Gang Liu, Xiujuan Du, Xu Hou, Xin Gao, Zhen Zhang, Zhansheng Shen, Changfu
Objective This study aimed to investigate the prevalence of glaucoma with associated factors in the rural populations of 10 provinces in China. Design A population-based cross-sectional study. Methods All participants aged 6 years or older from 10 provinces completed visual acuity testing, slit-lamp examination, ophthalmoscopy and non-contact tonometry. Glaucoma suspects underwent fundus photography
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Safety and effectiveness of the fluocinolone acetonide intravitreal implant (ILUVIEN): 3-year results from the European IRISS registry study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-15 Ramin Khoramnia, Tunde Peto, Frank Koch, Simon R Taylor, João Paulo Castro de Sousa, Lauren Hill, Clare Bailey, Usha Chakravarthy
Background The ILUVIEN Registry Safety Study was a multicentre, open-label, non-randomised, observational, phase 4 study designed to assess the safety and effectiveness of the fluocinolone acetonide (FAc) implant in all indications in real-world practices in Europe. Methods The study included data collected prospectively and retrospectively. Patients receiving FAc implants between 2013 and 2017 were
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Subretinal deposits in young patients treated with voretigene neparvovec-rzyl for RPE65-mediated retinal dystrophy Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-14 Jennifer Lopez, Mark Borchert, Thomas C Lee, Aaron Nagiel
We report a series of three young patients (ages: 22 months, 2 years, and 5 years) who developed subretinal deposits at post-operative week one following subretinal voretigene neparvovec-rzyl treatment for RPE65-mediated retinal dystrophy. In the 5-year-old, subretinal deposits were also observed in the inferior periphery of both eyes. All three patients experienced improved visual function with treatment
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Parapapillary choroidal microvascular density in acute primary angle-closure and primary open-angle glaucoma: an optical coherence tomography angiography study Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-13 Yanin Suwan, Masoud Aghsaei Fard, Nantinee Vilainerun, Purit Petpiroon, Apichat Tantraworasin, Chaiwat Teekhasaenee, Robert Ritch, Rahele Kafieh, Sahar Hojati, Wasu Supakontanasan
Back ground/aims To determine whether parapapillary choroidal microvasculature (PPCMv) density, measured by optical coherence tomography angiography, differed between acute primary angle-closure (APAC), primary open-angle glaucoma (POAG) and controls. Methods This is a prospective, cross-sectional, observational study. Data from 149 eyes from two academic referral centres were analysed. Automated PPCMv
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Nalbuphine as analgesic in preschool children undergoing ophthalmic surgery and the occurrence of emergence delirium Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-11 Nicolas Leister, Uwe Trieschmann, Sirin Yücetepe, Christoph Ulrichs, Nikolas Muenke, Stefanie Wendt, Christoph Menzel, Ludwig M Heindl
Background/aims Perioperative pain in children is often inadequately treated, and emergence agitation is common. The purpose of this analysis was to determine whether nalbuphine is suitable for perioperative eye pain and to analyse if it influences the occurrence of emergence delirium/agitation (EDA) in children undergoing ophthalmic surgery in general anaesthesia. Methods Retrospective cohort analysis
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Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-08 Liangbo L Shen, Shwetha Mangalesh, Suzanne M Michalak, Brendan McGeehan, Neeru Sarin, Joanne Finkle, Katrina P Winter, Du Tran-Viet, Eric J Benner, Lejla Vajzovic, Sharon F Freedman, Noelle Younge, C Michael Cotten, Mays El-Dairi, Gui-Shuang Ying, Cynthia Toth
Background/aims Neonatal insults from systemic diseases have been implicated in the pathway of impaired neurodevelopment in preterm infants. We aimed to investigate the associations between systemic health factors and retinal nerve fibre layer (RNFL) thickness in preterm infants. Methods We prospectively enrolled infants and imaged both eyes at 36±1 weeks postmenstrual age (PMA) using a hand-held optical
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Central macular OCTA parameters in glaucoma Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-07 Takashi Nishida, Won Hyuk Oh, Sasan Moghimi, Adeleh Yarmohammadi, Huiyuan Hou, Ryan Caezar C David, Alireza Kamalipour, Takuhei Shoji, Nevin El-Nimri, Jasmin Rezapour, Linda M Zangwill, Robert N Weinreb
Background/aims To investigate the relationship between the foveal avascular zone (FAZ) parameters assessed by optical coherence tomography angiography (OCTA) and central visual field parameters in glaucoma and healthy subjects. Methods One hundred and eighty-eight subjects (248 eyes), including 24 healthy (38 eyes), 37 glaucoma suspect (42 eyes, and 127 primary open angle glaucoma (POAG) patients
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Predicting the immediate impact of national lockdown on neovascular age-related macular degeneration and associated visual morbidity: an INSIGHT Health Data Research Hub for Eye Health report Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-07 Susan P Mollan, Dun Jack Fu, Ching-Yi Chuo, Jacqueline G Gannon, Wen Hwa Lee, J Jill Hopkins, Cian Hughes, Alastair K Denniston, Pearse A Keane, Ronald Cantrell
Objective Predicting the impact of neovascular age-related macular degeneration (nAMD) service disruption on visual outcomes following national lockdown in the UK to contain SARS-CoV-2. Methods and analysis This retrospective cohort study includes deidentified data from 2229 UK patients from the INSIGHT Health Data Research digital hub. We forecasted the number of treatment-naïve nAMD patients requiring
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Associations of ophthalmic and systemic conditions with incident dementia in the UK Biobank Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-07 Xianwen Shang, Zhuoting Zhu, Yu Huang, Xueli Zhang, Wei Wang, Danli Shi, Yu Jiang, Xiaohong Yang, Mingguang He
Aims To examine independent and interactive associations of ophthalmic and systemic conditions with incident dementia. Methods Our analysis included 12 364 adults aged 55–73 years from the UK Biobank cohort. Participants were assessed between 2006 and 2010 at baseline and were followed up until the early of 2021. Incident dementia was ascertained using hospital inpatient, death records and self-reported
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Surgeon effects on cataract refractive outcomes are minimal compared with patient comorbidity and gender: an analysis of 490 987 cases Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-07 Rachael Hughes, Petros Aristodemou, John M Sparrow, Stephen Kaye
Aim To investigate effect of patient age, gender, comorbidities and surgeon on refractive outcomes following cataract surgery. Methods Study population: patients on UK national ophthalmic cataract database on cataract operations undertaken between 1 April 2010 and 31 August 2018. Variables examined included gender, age, diabetic retinopathy, glaucoma, high myopia, inherited retinal disease, optic nerve
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Associations of systemic health and medication use with the enlargement rate of geographic atrophy in age-related macular degeneration Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-06 Liangbo L Shen, Yangyiran Xie, Mengyuan Sun, Aneesha Ahluwalia, Michael M Park, Benjamin K Young, Lucian V Del Priore
Background The associations of geographic atrophy (GA) progression with systemic health status and medication use are unclear. Methods We manually delineated GA in 318 eyes in the Age-Related Eye Disease Study. We calculated GA perimeter-adjusted growth rate as the ratio between GA area growth rate and mean GA perimeter between the first and last visit for each eye (mean follow-up=5.3 years). Patients’
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Comparison of biometric and refractive changes in intermittent exotropia with and without overminus lens therapy Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-06 Jit B Ale Magar, Shaheen P Shah, Shuan Dai
Background Overminus lens is an effective non-surgical treatment of intermittent exotropia (IXT). Whether this treatment causes development of myopia is recently debated. This study evaluated ocular biometric changes in IXT children treated with and without overminus lens. Methods Children with IXT were randomly assigned to control and overminus groups. Cycloplegic refraction, axial length and other
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Patient-reported outcome measures should not be the primary outcome in glaucoma clinical trials of disease modification Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-05 Alessandro Rabiolo, Keith Barton, Andrew Ian McNaught
In the 19th century, Sir William Osler, one of the fathers of modern medicine, stated that ‘ The good physician treats the disease; the great physician treats the patient who has the disease’, indicating that, as clinicians, we should pursue a patient-centred, rather than disease-centred approach. In the attempt to provide more patient-centred holistic care, there has been increasing interest in patient-reported
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Extending the utility of anterior corneal buttons through refrigeration and glycerol cryopreservation: utility rate and outcome analysis Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-05 Hsin-Yu Liu, Hsiao Sang Chu, Wei-Li Chen, I-Jong Wang, Fung-Rong Hu
Background/aims To evaluate the utility rate, indication, outcome, and cost of refrigeration and glycerol cryopreservation for storing anterior corneal buttons during endothelial keratoplasty for subsequent use in tectonic lamellar patch grafting. Method Anterior corneal buttons collected after precutting or prestripping during endothelial keratoplasty from January 2014 to December 2019 were preserved
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PandAcuity in paediatrics: a novel clinical measure of visual function based on the panda illusion Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-05 Carina Kelbsch, Bettina Spieth, Eberhart Zrenner, Dorothea Besch, Torsten Straßer
Background/aims To evaluate the PandAcuity test for visual function testing in a paediatric cohort and to examine its agreement with conventional visual acuity (VA) testing. Methods PandAcuity scores were determined in 152 children (77 males) aged between 3 and 15 years after VA testing (LEATM-test, E-chart, Landolt-C-rings or numbers). The PandAcuity test consisted of illusions made up from silhouettes
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Biosimilar SB11 versus reference ranibizumab in neovascular age-related macular degeneration: 1-year phase III randomised clinical trial outcomes Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-07-01 Neil M Bressler, Miroslav Veith, Jan Hamouz, Jan Ernest, Dominik Zalewski, Jan Studnička, Attila Vajas, András Papp, Gabor Vogt, James Luu, Veronika Matuskova, Young Hee Yoon, Tamás Pregun, Taehyung Kim, Donghoon Shin, Inkyung Oh, Hansol Jeong, Mercy Yeeun Kim, Se Joon Woo
Background/Aims To provide longer-term data on efficacy, safety, immunogenicity and pharmacokinetics (PK) of ranibizumab biosimilar SB11 compared with the reference ranibizumab (RBZ) in patients with neovascular age-related macular degeneration (nAMD). Methods Setting : Multicentre. Design : Randomised, double-masked, parallel-group, phase III equivalence study. Patient population : ≥50 years old participants
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Increased incidence of endophthalmitis after vitrectomy relative to face mask wearing during COVID-19 pandemic Br. J. Ophthalmol. (IF 5.908) Pub Date : 2022-06-30 Taiji Sakamoto, Hiroto Terasaki, Toshifumi Yamashita, Hideki Shiihara, Ryoh Funatsu, Akinori Uemura
Background/aims To determine the incidence and causative pathogens of endophthalmitis after vitrectomy during strict face mask wearing in the COVID-19 period. Methods This was a retrospective multicentre study including 31 ophthalmological institutions of the Japanese Retina and Vitreous Society or Japan-Clinical Retina Study group. Patients who had undergone vitrectomy during 2019, the pre-COVID-19