Background/Aims To provide a comprehensive and internationally standardised Cornea and Ocular Surface Disease (C&OSD) dataset for use in electronic health records (EHRs). Methods This was an international consensus study conducted through roundtable discussions involving 35 international experts specialising in the field of C&OSD. The Royal College of Ophthalmologists dataset guidelines were used to

Purpose To explore intergenerational changes in the myopia epidemic in China in a sample of twins and their parents. Methods Longitudinal cohort study. A total of 686 children with baseline age from 7 to 15 years were followed annually from 2006 to 2018. Cycloplegic refractions and ocular biometry of the children and non-cycloplegic refractions and ocular biometry of the parents were measured. Results

Background/aims To examine the association between artificial intelligence (AI)-driven segmentation of geographic atrophy (GA) on optical coherence tomography (OCT) and visual sensitivity loss quantified by defect-mapping microperimetry, a testing strategy optimised to quantify the spatial extent of deep visual sensitivity losses. Methods 50 individuals with GA secondary to age-related macular degeneration

Purpose To evaluate the impact of intraocular lens (IOL) positional change following cataract surgery, measured by swept-source optical coherence tomography (SS-OCT) in eyes with different lens thicknesses (LTs), and its influence on the accuracy of IOL power calculation. Methods This prospective cohort study enrolled patients who planned to undertake phacoemulsification and monofocal IOL implantation

This case-control study found male gender, prior anterior uveitis, and glaucoma as significant risk factors for CMV corneal endotheliitis in 1194 corneal transplant cases, emphasising importance of vigilant postoperative monitoring, especially in the first year post-transplant. This study examined the impact of social determinants of health on keratoconus and found that higher levels of education are

When corneal endotheliitis was first reported by Khodadoust and Attarzadeh in 1982, it was thought to be caused by an autoimmune process.1 The clinical presentation was similar to corneal allograft rejection due to the presence of linear corneal keratic precipitates (KPs). PCR testing in a patient with a similar clinical presentation in Japan led to discovery of the herpes simplex virus.2 Later, Koizumi

Purpose This study was designed to investigate risk factors for the development of cytomegalovirus (CMV) corneal endotheliitis following corneal transplantation. Methods We retrospectively analysed 1225 corneal transplants for bullous keratopathy between 2011 and 2021. 31 cases who were administered the treatment of CMV corneal endotheliitis preoperatively were excluded, and 1194 cases were analysed

Background/aims Clinical risk factors for keratoconus (KCN) have previously been established. While the impact of the social determinants of health on the epidemiology and pathophysiology of KCN has been explored, further study of these associations is needed in large and diverse populations. This cross-sectional study determines how education level and income impact the prevalence of KCN in the USA

Background To reveal clinical findings related to metastatic conjunctival melanoma. Methods 10 ophthalmic oncology centres (9 countries and 4 continents) shared data to create a large clinical case series. The main outcome measures were the incidence and cumulative risk of systemic metastasis, study mortality rates and Kaplan-Meier patient mortality after developing conjunctival melanoma metastasis

Background/aims The purpose of this study is to define genetic factors associated with anterior uveitis through genome-wide association study (GWAS). Methods In this GWAS meta-analysis, we combined data from the FinnGen, Estonian Biobank and UK Biobank with a total of 12 205 anterior uveitis cases and 917 145 controls. We performed a phenome-wide association study (PheWAS) to investigate associations

Background The present study aims to identify the relationship between longitudinal changes in corneal hysteresis (CH) and progressive retinal nerve fibre layer (RNFL) thinning in a cohort of medically controlled, early-to-moderate open-angle glaucoma (OAG) patients with a history of laser refractive surgery (LRS). Methods A total of 123 consecutive eyes with a diagnosis of medically controlled (peak

Background To evaluate the impact of testing frequency on the time required to detect statistically significant glaucoma progression for ganglion cell complex (GCC) with optical coherence tomography (OCT). Materials and methods From multicentre glaucoma registries, 332 eyes of 201 glaucoma patients were enrolled over an average of 4.4 years. Patients with 4 or more OCT tests were selected to calculate

Background/aims Bleb characteristics in the area around the plate following glaucoma drainage device (GDD) surgery are difficult to evaluate on slit lamp examination. Ultrasound sonography could be used for more detailed visualisation. The aim of this study was to describe bleb configuration after PAUL glaucoma implant (PGI) surgery and evaluate the possible correlation with intraocular pressure (IOP)

Purpose To explore the relationship between characteristics of macular neovascularisation (MNV) and photoreceptor integrity in patients with neovascular age-related macular degeneration (nAMD). Methods This prospective study enrolled treatment-naïve nAMD eyes and conducted a 3-month follow-up. 16 quantitative MNV features were evaluated using optical coherence tomography angiography, and the impaired

Purpose To quantitatively explore preretinal abnormal tissue (PAT) in macula-on rhegmatogenous retinal detachment (RRD) before and after surgery. Methods In this case-series study, PAT was detected by en-face optical coherence tomography images with custom slabs in eyes that underwent pars plana vitrectomy and SF6 for macula-on RRD. Main outcome measures were PAT area at baseline, 3-month and 6-month

Background Anterior segment ischaemia (ASI) is a rare but feared complication associated with strabismus surgery, arising from damage of the anterior ciliary arteries that run along the extraocular rectus muscles. It has been reported that the risk of ASI following strabismus surgery increases when the vertical rectus muscles are involved. The aim of the present study was to monitor anterior segment

Background Differentiating arteritic anterior ischaemic optic neuropathy (A-AION) due to giant cell arteritis (GCA) from non-arteritic anterior ischaemic optic neuropathy (NA-AION) may pose a diagnostic challenge. Our study aimed to assess the use of standard orbital MRI in distinguishing ocular manifestations of GCA from NA-AION. Methods This study included 25 consecutive patients (11 GCA, 14 NA-AION)

Background To report the presenting clinical, serological and treatment profiles of 1439 patients with thyroid eye disease (TED) from a tertiary centre in Hong Kong. Study populations Consecutive patients with TED presented to the Thyroid Eye Clinic (TEC), the Chinese University of Hong Kong between 2014 and 2023. Methods Prospective cohort and masked review of medical records and orbital images. Results

Purpose To assess the prevalence and risk factors of myopic macular degeneration (MMD) in young and middle-aged individuals with high myopia in Changsha, central China. Methods A total of 445 adults with high myopia (worse than or equal to −5.0 D) were examined between 2021 and 2023. Autorefraction and biometry using IOLMaster were conducted, and fundus photos were graded for MMD using Meta-PM criteria

Background Orbital cavernous venous malformations (OCVMs) are the most common primary orbital mass lesion and presenting symptoms are usually secondary to a mass effect. Surgical excision presents unique challenges and vision loss is a rare, but devastating, complication. This review aims to identify risk factors for vision loss with excision of OCVMs. Method A systematic search of the databases PubMed/MEDLINE

Aims To describe a simple surgical technique consisting of opening the vertical graft-host junction (GHJ) to manage high astigmatism following deep anterior lamellar keratoplasty (DALK) and to report postoperative visual and topographic outcomes. Methods This is a retrospective interventional case series. Patients affected by high astigmatism after DALK underwent progressive opening of the previous

Background Contact lenses (CLs), used by approximately 140 million people globally, can induce corneal warpage, altering corneal geometry. This impacts corneal imaging, influencing diagnostic assessments, follow-ups and pre-operative evaluations. This systematic review aimed to determine the optimal CL cessation period before corneal imaging. Methods A systematic literature search was conducted across

Background/aims This study aimed to develop a predictive equation for Functional Field Score (FFS), a component of the Functional Vision Score (FVS) derived from binocular Esterman test results via automated perimetry (AP) and to evaluate agreement with Goldmann perimetry (GP)-based FFS. Methods This retrospective multicentre study included 240 patients (mean age: 61±17.5 years) who underwent both

To describe tocilizumab (TCZ) effectiveness in 15 children with refractory non-infectious uveitis. Reported outcomes are the number of relapses before and after treatment, steroid-sparing effect and drug retention rate. Macular oedema, fluorangiographic findings and ocular complications are also reported. The mean number of ocular relapses significantly decreased from 314 per 100 eyes/year to 106 per

Background Pathological myopia (PM) has emerged as a leading cause of global visual impairment, early detection and precise grading of PM are crucial for timely intervention. The atrophy, traction and neovascularisation (ATN) system is applied to define PM progression and stages with precision. This study focuses on constructing a comprehensive PM image dataset comprising both fundus and optical coherence

Aims To assess and compare the risk of adverse renal events among patients with diabetic macular oedema (DME) who were treated with either intravitreal ranibizumab or aflibercept in Taiwan. Methods We conducted a population-based retrospective cohort study and employed a target trial emulation framework using Taiwan’s National Health Insurance Database from 2011 to 2018. Patients aged over 20 years

Background Due to technical limitations of commonly used tonometry devices, the effects of physical exercise on intraocular pressure (IOP) have never been studied during exercise. This study continuously monitored IOP variations in patients with glaucoma during physical exercise using an implanted IOP microsensor. Methods In total, 10 participants (six male and four female) with open-angle glaucoma

Background/Aims To ascertain factors associated with persistent diplopia after orbital fracture reconstruction. Methods In this retrospective study, we reviewed 798 cases with depressed fragment fracture at the Department of Kyoto Prefectural University of Medicine Hospital between January 2009 and November 2023. The restriction of extraocular movements and diplopia was assessed using the Hess area

Aim To evaluate the impact of fluid volume fluctuations quantified with artificial intelligence in optical coherence tomography scans during the maintenance phase and visual outcomes at 12 and 24 months in a real-world, multicentre, national cohort of treatment-naïve neovascular age-related macular degeneration (nAMD) eyes. Methods Demographics, visual acuity (VA) and number of injections were collected

Background/aims This work aims to clarify whether micropulse transscleral cyclophotocoagulation (MPCPC) is gentler in terms of postoperative inflammation and is better tolerated compared with continuous wave cyclophotocoagulation (CWCPC). Methods Prospective, randomised controlled, interventional, single-centre trial performed at the Ludwig Maximilians University Munich from January 2020 to July 2023

Objective To establish the influence of different optical coherence tomography (OCT) biomarkers at baseline treatment on the potential response to anti-vascular endothelial growth factor (VEGF) treatment for diabetic macular oedema (DME). Methods Multicentric, retrospective, case-series study in patients with DME switched to dexamethasone implant injections (DEX-i) after anti-VEGF in real clinical

Background Cataract surgery has been shown to reduce the risk of developing dementia in the future; however, its impact on different dementia subtypes, including vascular dementia, remains unknown. Moreover, its dementia-protecting effect among cataract patients with common mental disorder (CMD) remains unclear. Methods Patients aged 65 or older diagnosed with cataract between 2012 and 2021 were included

Background/aims Many countries provide social support to patients with severe sight impairment (blindness). In the UK, these benefits require a certificate of visual impairment (CVI) which requires referral by a consultant ophthalmologist. Many eligible patients do not receive a CVI due to personal choice or lack of consideration or communication by their doctor. This study investigated the frequency

Aims To determine the effect of continuing anti-vascular endothelial growth factor (VEGF) injections on the progression of macular atrophy (MA) during remission of neovascular age-related macular degeneration (nAMD). Methods In this retrospective cohort study, 59 eyes with nAMD with at least 6-month remission (disease inactivity) were analysed and were grouped into two. In group 1, anti-VEGF injections

Background/aims We investigated the impact of potential risk factors on the development of incident glaucoma in individuals with myopia. Methods This prospective cohort study investigated participants aged 40–69 years from the UK Biobank. Participants were classified based on the degree of myopia: non-myopic (spherical equivalent (SE)≤−0.5D), mild myopia (−3.0D

Aims To assess choriocapillaris flow deficit percentage (CCFD%) across stages of dry age-related macular degeneration (AMD) using swept-source optical coherence tomography angiography (SS-OCTA). Methods This cross-sectional, observational study included 270 eyes (182 patients), classified as early (70 eyes), intermediate (121 eyes) and geographic atrophy (GA, 79 eyes). Participants underwent a complete

Objective To validate a self-administered Home Early Treatment Diabetic Retinopathy Study (H-ETDRS) visual acuity (VA) test and to assess its accuracy in detecting VA decline in patients with retinal diseases. Methods A validation group of 156 participants and a testing group of 100 participants with diabetic retinopathy and age-related macular degeneration were recruited. All participants underwent

Aims To investigate rule-based and deep learning (DL)-based methods for the automatically generating natural language diagnostic reports for macular diseases. Methods This diagnostic study collected the ophthalmic images of 2261 eyes from 1303 patients. Colour fundus photographs and optical coherence tomography images were obtained. Eyes without retinal diseases as well as eyes diagnosed with four

Aims Our aim is to develop a deep learning-based system for automatically identifying and classifying benign and malignant tumours of the eyelid to improve diagnostic accuracy and efficiency. Methods The dataset includes photographs of normal eyelids, benign and malignant eyelid tumours and was randomly divided into a training and validation dataset in a ratio of 8:2. We used the training dataset to

Background Inherited retinal diseases (IRDs) are the leading cause of blindness in young people in the UK. Despite significant improvements in genomics medicine, the diagnosis of these conditions remains challenging, and around 40% do not receive a definite genetic diagnosis after extensive genetic testing. This survey aims to investigate the experience of individuals affected by IRDs, their relatives

Corneal disease ranks as the fifth leading cause of global blindness, affecting more than 10 million individuals. Donor corneal transplantation, keratoplasty, remains the mainstay of addressing loss of corneal clarity. Historically, full-thickness penetrating keratoplasty (PK) has been one of the most successful and widely performed transplant procedures, although predominantly available in developed

Purpose To explore macular pigment optical density (MPOD) dynamics in stage 2 and stage 3 epiretinal membranes (ERMs) and to evaluate its pre and postoperative modifications. Furthermore, the study assessed the potential of MPOD as a prognostic biomarker in ERM management. Methods A cohort of stage 2 (n=21) and 3 (n=20) ERM patients, matched for age and gender, underwent clinical evaluation at baseline

Aim To evaluate and compare the efficacy of combination treatment using 0.025% atropine and Defocus Incorporated Multiple Segments (DIMS) spectacle lenses to 0.025% atropine and single vision (SV) spectacle lenses in slowing myopia progression in children with myopia. Methods Randomised controlled trial conducted on children aged 4–16 years with myopia between −1.00D and −6.00D and astigmatism ≤2.00D

Statistically significant worsening of myopia progression was observed in children after COVID-19 home confinement. Elementary school age children demonstrated the greatest increase in myopia prevalence. Low myopia patients demonstrated the greatest change in mean spherical equivalent. Using handheld swept source optical coherence tomography, markers of foveal immaturity, including shallower foveal

Randomised controlled trials (RCTs) remain the gold standard in medical research; however, their high cost can bias which interventions receive rigorous assessment. Other limitations are increasingly recognised: RCTs often have poor external validity because they do not represent diverse populations1 and many fail to meet recruitment targets. Observational data, such as that from clinical registries

In this paper, we describe key strategies to guide global collaborative efforts to further reduce the burden of myopia and myopia-related visual impairment. A modified Delphi method was applied as an iterative multistage process to collect expert and stakeholders’ opinions and extract consensus strategies regarding myopia diagnosis, prevention and control. Anonymous pre-meeting preparation rounds,

Background Remote learning during the COVID-19 pandemic caused behavioural changes such as increased screen time and decreased outdoor time. This study aimed to investigate myopia progression in children during the COVID-19 pandemic. Methods This was a retrospective observational study performed among 2064 patients ages 2–17 with cycloplegic refractions in the months of January 2019–March 2021 at a

Background/aims Handheld swept-source optical coherence tomography (SS-OCT) was previously used to measure foveal maturity through semiautomated methods in awake premature infants. This study assesses the relationship between foveal maturity and retinopathy of prematurity (ROP) severity. Methods This is a prospective, observational study using handheld SS-OCT imaging of premature infants undergoing

Background This study aimed to characterise imaging artefacts in the lacrimal gland using swept-source optical coherence tomography (SS-OCT) in patients with dry eye disease (DED) and healthy participants and identify risk factors for these artefacts. Methods In total, 151 eyes, including 104 from patients with DED and 47 from non-DED participants, were analysed. Demographic data collection, comprehensive

Background/Aims To explore the outcomes of conjunctival flap (CF) followed by keratoplasty in patients with severe infectious keratitis (IK) unresponsive to medical treatment. Methods This is a retrospective monocentric study including 29 eyes of 29 patients with IK resistant to antibiotic treatment associated with stromal ulcer deepening to ≥50% of corneal thickness. All eyes underwent Gundersen’s

Purpose To compare clinical outcomes of bilateral implantation of hybrid multifocal intraocular lenses (IOLs) versus mix-and-match implantation of hybrid multifocal and extended-depth-of-focus (EDOF) versus mix-and-match implantation of hybrid multifocal and enhanced monofocal IOLs. Methods Patients with bilateral age-related cataract were randomised in one of three groups: group 1, bilateral hybrid

Background/aims To identify whether an intact retinal nerve fibre layer (RNFL) thickness profile could determine the location of the earliest RNFL defect in glaucoma. Methods Retrospective longitudinal cohort study of patients with initial unilateral glaucoma who eventually developed new glaucoma in the fellow eye. Guided progression analysis (GPA) of serial optical coherence tomography (OCT) examinations

Objective To evaluate nyctohemeral effects of topical beta-adrenoceptor blocking agents and their fixed combinations on intraocular pressure (IOP) in patients with primary open-angle glaucoma implanted with an ocular telemetry sensor. Methods 22 patients who had previously been implanted with a sulcus-based IOP sensor (eyemate) were included in this prospective clinical trial. Three classes of medications

Aims To compare the baseline clinical characteristics and patterns of visual field defects between high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) in the Laser in Glaucoma and Ocular Hypertension (LiGHT) China subjects. Methods All patients (n=622) were recruited at Zhongshan Ophthalmic Center from 2015 to 2019. 1105 open-angle glaucoma eyes of 622 patients were classified as NTG (n=559)

Purpose This study aimed to identify the various clinical characteristics and ocular imaging features of ocular toxoplasmosis (OT) in HIV patients. Methods Observational retrospective study of 52 eyes of 38 HIV patients with OT. Results 68% of patients were male. 53.8% of eyes had keratic precipitates, anterior chamber cells were seen in 61.5%. 57.69% (n=30) eyes had de novo presentation of retinitis

Background/aims Intravitreal injection (IVT) of anti-vascular endothelial growth factor agents is the standard of care for several retinal diseases but can cause intraocular pressure (IOP) elevations. This study investigates short-term postinjection IOP changes following aflibercept 8 mg and faricimab, compared with aflibercept 2 mg. Methods This observational, prospective study included 90 patients

Background To compare individual ophthalmologists grouped as outliers or non-outliers based on the mean 12-month visual acuity (VA) outcomes for their patients with neovascular age-related macular degeneration (nAMD). Methods This prospectively designed database study included treatment-naïve eyes with nAMD starting vascular endothelial growth factor inhibitors between July 2018 and April 2023 in Australia

Aims To examine the association between colour vision deficiency (CVD) and other ophthalmic disorders including amblyopia, strabismus and ametropia in a large population study. Methods The retrospective, cross-sectional study included 916 388 Israeli army male recruits who had their premilitary medical assessment at the age of 16–18 years from 2000 to 2020, analysing the prevalence of ophthalmic disorders

Background/aims To identify the metabolic underpinnings of retinal aging and examine how it is related to mortality and morbidity of common diseases. Methods The retinal age gap has been established as essential aging indicator for mortality and systemic health. We applied neural network to train the retinal age gap among the participants in UK Biobank and used nuclear magnetic resonance (NMR) to profile

Prior studies of teprotumumab for thyroid eye disease report proptosis reduction in millimetres, which does not fully capture teprotumumab’s clinical effect since a given number of millimetres change can be of variable impact depending on patients’ degree of pre-treatment proptosis. In this retrospective study analysing proptosis change as a percentage of pre-treatment proptosis among 119 patients