样式: 排序: IF: - GO 导出 标记为已读
-
Long-term outcomes of glued (sutureless) amniotic membrane transplantation in acute Stevens-Johnson syndrome/toxic epidermal necrolysis: a comparative study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-15 Ramy Rashad, James T Kwan, Swapna S Shanbhag, Panotsom Ngowyutagon, Musa Saeed, Mohammad A Tahboub, Abid Haseeb, James Chodosh, Hajirah N Saeed
Purpose To compare the effectiveness and efficiency of a glued (sutureless) technique for amniotic membrane transplantation (AMT) with a traditional sutured one in the setting of acute Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Methods This retrospective cohort study evaluated all patients diagnosed with SJS/TEN between 2008 and 2020 within our hospital network who received AMT
-
Using artificial intelligence to improve human performance: efficient retinal disease detection training with synthetic images Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-14 Hitoshi Tabuchi, Justin Engelmann, Fumiatsu Maeda, Ryo Nishikawa, Toshihiko Nagasawa, Tomofusa Yamauchi, Mao Tanabe, Masahiro Akada, Keita Kihara, Yasuyuki Nakae, Yoshiaki Kiuchi, Miguel O Bernabeu
Background Artificial intelligence (AI) in medical imaging diagnostics has huge potential, but human judgement is still indispensable. We propose an AI-aided teaching method that leverages generative AI to train students on many images while preserving patient privacy. Methods A web-based course was designed using 600 synthetic ultra-widefield (UWF) retinal images to teach students to detect disease
-
Validation of a deep learning model for automatic detection and quantification of five OCT critical retinal features associated with neovascular age-related macular degeneration Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-14 Federico Ricardi, Jonathan Oakley, Daniel Russakoff, Giacomo Boscia, Paolo Caselgrandi, Francesco Gelormini, Andrea Ghilardi, Giulia Pintore, Tommaso Tibaldi, Paola Marolo, Francesco Bandello, Michele Reibaldi, Enrico Borrelli
Purpose To develop and validate a deep learning model for the segmentation of five retinal biomarkers associated with neovascular age-related macular degeneration (nAMD). Methods 300 optical coherence tomography volumes from subject eyes with nAMD were collected. Images were manually segmented for the presence of five crucial nAMD features: intraretinal fluid, subretinal fluid, subretinal hyperreflective
-
Association between corneal hysteresis and glaucoma in a Japanese population: the Hisayama Study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-12 Kohta Fujiwara, Emi Ueda, Jun Hata, Satoko Nakano, Sawako Hashimoto, Shun Nakamura, Yusuke Murakami, Toshiaki Kubota, Takeshi Yoshitomi, Toshiharu Ninomiya, Koh-Hei Sonoda
Aims To investigate the association between corneal hysteresis and the presence of glaucoma and its subtypes in a general Japanese population. Methods We analysed the data of 2338 Japanese community-dwellers aged ≥40 years (1059 men, 1279 women) who underwent an eye examination in 2018 as part of the population-based, cross-sectional Hisayama Study. Participants were divided into quartile levels of
-
Dry eye symptoms and health-related quality of life among Chinese individuals: a national-based study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-12 Jia-Yan Kai, Yi-Bo Wu, Bing Shi, Dan-Lin Li, Xing-Xuan Dong, Pei Wang, Chen-Wei Pan
Aims To assess the impact of dry eye symptoms (DESs) on health-related quality of life (HRQOL) among Chinese residents. Methods A total of 21 916 participants were involved in this nationwide cross-sectional study. All of them completed the Ocular Surface Disease Index-6 and the five-level European Quality of Life 5-Dimensional (EQ-5D) Questionnaire to assess the severity of DES and HRQOL, respectively
-
Continuous oxygen saturation and risk of retinopathy of prematurity in a Japanese cohort Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-06 Hiroshi Kubota, Yoko Fukushima, Ryo Kawasaki, Takao Endo, Yoshikazu Hatsukawa, Hiromi Ineyama, Katsuya Hirata, Shinya Hirano, Kazuko Wada, Kohji Nishida
Background/aims We assessed the associations between retinopathy of prematurity (ROP) and continuous measurements of oxygen saturation (SpO2), and developed a risk prediction model for severe ROP using birth data and SpO2 data. Methods This retrospective study included infants who were born before 30 weeks of gestation between August 2009 and January 2019 and who were screened for ROP at a single hospital
-
Exploring AI-chatbots’ capability to suggest surgical planning in ophthalmology: ChatGPT versus Google Gemini analysis of retinal detachment cases Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-06 Matteo Mario Carlà, Gloria Gambini, Antonio Baldascino, Federico Giannuzzi, Francesco Boselli, Emanuele Crincoli, Nicola Claudio D’Onofrio, Stanislao Rizzo
Background We aimed to define the capability of three different publicly available large language models, Chat Generative Pretrained Transformer (ChatGPT-3.5), ChatGPT-4 and Google Gemini in analysing retinal detachment cases and suggesting the best possible surgical planning. Methods Analysis of 54 retinal detachments records entered into ChatGPT and Gemini’s interfaces. After asking ‘Specify what
-
Association between age-related macular degeneration and risk of incident cancer Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-28 Junhee Park, Wonyoung Jung, Kyungdo Han, Bongseong Kim, Seung-Yeon Lee, Je Moon Yoon, Dong Hui Lim, Dong Wook Shin
Background/aims Age-related macular degeneration (AMD) and cancer may share similar risk factors, indicating possible common pathogenic pathways. We aimed to describe the site-specific cancer risk based on the relationship of AMD with visual disability (VD) status. Methods This was a population-based cohort study using data from the Korean National Health Insurance Service database (2009–2019) including
-
Relationship of posterior peripheral corneal layers and the trabecular meshwork: an immunohistological and anatomical study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-28 Burçin Kepez Yildiz, Rui Freitas, Perla Filippini, Fatima Habroosh, Dalia G Said, Harminder Singh Dua, Prity Sahay
Background/Aim With the popularity of endothelial keratoplasty (EK) procedures, Descemet membrane (DM) EK and pre-Descemet EK, considerable work has been done on understanding the posterior corneal anatomy. Most of the information available relates to the central cornea. We evaluated the peripheral cornea to explore the immunohistological and anatomical relationship between the pre-Descemet layer (PDL)
-
Diagnostic utility of point-of-care ultrasound and optical coherence tomography for papilloedema in children: a prospective pilot study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-27 Hannah H Chiu, Nouf Al-Farsi, Agnes M F Wong, Adrienne Davis, Mark O Tessaro, Michael J Wan
Background/Aims Papilloedema is an important sign of serious neurological disease, but it can be difficult to detect on funduscopy. The purpose of this study was to determine the diagnostic accuracy of point-of-care ultrasound (POCUS) and optical coherence tomography (OCT) for detecting papilloedema in children. Methods This was a prospective observational study at a tertiary care paediatric hospital
-
Reproducibility of consecutive automated telemetric noctodiurnal IOP profiles as determined by an intraocular implant Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-26 Jacqueline J O N van den Bosch, Vincenzo Pennisi, Harsha Laxmana Rao, Kaweh Mansouri, Robert Weinreb, Hagen Thieme, Michael B Hoffmann, Lars Choritz
Background Intraocular pressure (IOP) monitoring in glaucoma management is evolving with novel devices. We investigated the reproducibility of 24 hour profiles on two consecutive days and after 30 days of self-measurements via telemetric IOP monitoring. Methods Seven primary patients with open-angle glaucoma previously implanted with a telemetric IOP sensor in one eye underwent automatic measurements
-
Automated identification of fleck lesions in Stargardt disease using deep learning enhances lesion detection sensitivity and enables morphometric analysis of flecks Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-26 Jasdeep Sabharwal, Tin Yan Alvin Liu, Bani Antonio-Aguirre, Mya Abousy, Tapan Patel, Cindy X Cai, Craig K Jones, Mandeep S Singh
Purpose To classify fleck lesions and assess artificial intelligence (AI) in identifying flecks in Stargardt disease (STGD). Methods A retrospective study of 170 eyes from 85 consecutive patients with confirmed STGD. Fundus autofluorescence images were extracted, and flecks were manually outlined. A deep learning model was trained, and a hold-out testing subset was used to compare with manually identified
-
Genetic landscape and prognosis of conjunctival melanoma in Chinese patients Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-21 Hanhan Shi, Hao Tian, Tianyu Zhu, Jie Chen, Shichong Jia, Chunyan Zong, Qili Liao, Jing Ruan, Shengfang Ge, Yamin Rao, Mei Dong, Renbing Jia, Yimin Li, Shiqiong Xu, Xianqun Fan
Aims Conjunctival melanoma (CoM) is a rare but highly lethal ocular melanoma and there is limited understanding of its genetic background. To update the genetic landscape of CoM, whole-exome sequencing (WES) and targeted next-generation sequencing (NGS) were performed. Methods Among 30 patients who were diagnosed and treated at Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School
-
European Glaucoma Society research priorities for glaucoma care Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-20 Augusto Azuara-Blanco, Noleen McCorry, Andrew J Tatham, Stelios Georgoulas, Panayiota Founti, Cedric Schweitzer, Frances Meier-Gibbons, Philippe Denis, Anja Tuulonen, Gauti Johannesson, José María Martínez de la Casa, Verena Prokosch, Dimitrios A Giannoulis, Luis Abegão Pinto, David Garway-Heath, Fotis Topouzis
Background/Aims The goal of health research is to improve patients care and outcomes. Thus, it is essential that research addresses questions that are important to patients and clinicians. The aim of this study was to develop a list of priorities for glaucoma research involving stakeholders from different countries in Europe. Methods We used a three-phase method, including a two-round electronic Delphi
-
At a glance Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Frank Larkin
The authors' fusion model method works as a helpful tool for improving pterygium detection and grading accuracy in the context of insufficient smartphone data in the absence of a mobile mature database. Collagen type XII, a regulator of corneal form and stability, is undetectable in Bowman’s layer of keratoconic corneas, suggesting a possible integral role in the pathogenesis of keratoconus. Disc damage
-
New insights on the role of microRNAs in retinal Müller glial cell function Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Weijie Jiang, Siqi He, Logen Liu, Xia Meng, Jing Lu, Juan Li, Tuo Chen, Ying Xu, Qiguo Xiao, Ling Qi, Jia Zhang
MicroRNAs belong to the family of non-coding RNAs that participate in cell proliferation, cell death and development. The Müller glial cells are the inherent and specific neuroglia cells in the retinal organisation and play significant roles in retinal neuroprotection, organisational maintenance, inflammation and immunity, regeneration, and the occurrence and development of retinal diseases. However
-
Accurate detection and grading of pterygium through smartphone by a fusion training model Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Yuwen Liu, Changsheng Xu, Shaopan Wang, Yuguang Chen, Xiang Lin, Shujia Guo, Zhaolin Liu, Yuqian Wang, Houjian Zhang, Yuli Guo, Caihong Huang, Huping Wu, Ying Li, Qian Chen, Jiaoyue Hu, Zhiming Luo, Zuguo Liu
Background/aims To improve the accuracy of pterygium screening and detection through smartphones, we established a fusion training model by blending a large number of slit-lamp image data with a small proportion of smartphone data. Method Two datasets were used, a slit-lamp image dataset containing 20 987 images and a smartphone-based image dataset containing 1094 images. The RFRC (Faster RCNN based
-
Collagen type XII is undetectable in keratoconus Bowman’s layer Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Mohammed Rigi, Hyeck-Soo Son, Loren Moon, Mario Matthaei, Divya Srikumaran, Albert S Jun, Charles G Eberhart, Uri S Soiberman
Purpose Corneal biomechanical failure is the hallmark of keratoconus (KC); however, the cause of this failure remains elusive. Collagen type XII ( COL12A1 ), which localises to Bowman’s layer (BL), is thought to function in stress-bearing areas, such as BL. Given the putative protective role of COL12A1 in biomechanical stability, this study aims to characterise COL12A1 expression in all corneal layers
-
Differentiating stages of functional vision loss from glaucoma using the Disc Damage Likelihood Scale and cup:disc ratio Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Heiko Philippin, Einoti Naino Matayan, Karin Marianne Knoll, Edith Macha, Sia Mbishi, Andrew Makupa, Cristóvão Daniel Matsinhe, Isac Vasco da Gama, Mário Jorge Monjane, Joyce Awum Ncheda, Francisco Alcides Francisco Mulobuana, Elisante Muna, Nelly Fopoussi Guylene, Gus Gazzard, Ana Patricia Marques, Peter Shah, David Macleod, William Makupa, Matthew J Burton
Background Glaucoma staging is critical for treatment planning but has rarely been tested in severe/end-stage disease. We compared the performance of the Disc Damage Likelihood Scale (DDLS) and cup:disc ratio (CDR) using a functional glaucoma staging system (GSS) as the reference standard. Methods Post hoc analysis of a randomised controlled trial at the Eye Department of Kilimanjaro Christian Medical
-
Influence of choroidal microvasculature dropout on progressive retinal nerve fibre layer thinning in primary open-angle glaucoma: comparison of parapapillary β-zones and γ-zones Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Hye Seong Hwang, Eun Ji Lee, Jeong-Ah Kim, Seung Hyen Lee, Tae-Woo Kim
Background/aims To compare the influence of choroidal microvasculature dropout (cMvD) on progressive retinal nerve fibre layer (RNFL) thinning in glaucomatous eyes with parapapillary β-zones and γ-zones. Methods 294 eyes with primary open-angle glaucoma (POAG) and parapapillary atrophy (PPA) underwent optical coherence tomography (OCT) to determine the type of PPA and OCT angiography scanning of the
-
Iris volume change with physiologic mydriasis to identify development of angle closure: the Zhongshan Angle Closure Prevention Trial Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Chimei Liao, Harry Quigley, Yuzhen Jiang, Shengsong Huang, Wenyong Huang, David Friedman, Paul J Foster, Mingguang He
Aims To assess dynamic change of iris area (Iarea) and volume (VOL) with physiologic pupil dilation for progression of primary angle closure suspects. Methods Participants underwent baseline examinations including gonioscopy and anterior segment OCT (AS-OCT) as part of the Zhongshan Angle Closure Prevention Trial. The AS-OCT images were obtained both in the dark and light. Progression was defined as
-
Central visual field damage in glaucoma eyes with choroidal microvasculature dropout with and without high axial myopia Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Eleonora Micheletti, Nevin El-Nimri, Takashi Nishida, Sasan Moghimi, Jasmin Rezapour, Massimo A Fazio, Min Hee Suh, Christopher Bowd, Akram Belghith, Mark Christopher, Jost B Jonas, Robert N Weinreb, Linda M Zangwill
Purpose To characterise the relationship between a deep-layer microvasculature dropout (MvD) and central visual field (VF) damage in primary open-angle glaucoma (POAG) patients with and without high axial myopia. Design Cross-sectional study. Methods Seventy-one eyes (49 patients) with high axial myopia and POAG and 125 non-highly myopic POAG eyes (97 patients) were enrolled. Presence, area and angular
-
Long-term visual acuity outcomes following cataract surgery in eyes with ocular inflammatory disease Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Sapna Gangaputra, Craig Newcomb, Rebecca Armour, Dongseok Choi, Gui-shuang Ying, Sylvia Groth, Hosne Begum, Tonetta Fitzgerald, Pichaporn Artornsombudh, Ebenezer Daniel, Nirali Bhatt, Stephen Foster, Douglas Jabs, Grace Levy-Clarke, Robert Nussenblatt, James T Rosenbaum, H Nida Sen, Eric Suhler, Jennifer Thorne, Kurt Dreger, Jeanine Buchanich, John H Kempen
Purpose To evaluate the long-term visual acuity (VA) outcome of cataract surgery in inflammatory eye disease. Setting Tertiary care academic centres. Design Multicentre retrospective cohort study. Methods A total of 1741 patients with non-infectious inflammatory eye disease (2382 eyes) who underwent cataract surgery while under tertiary uveitis management were included. Standardised chart review was
-
Assessment of choriocapillaris and choroidal vascular changes in posterior uveitis using swept-source wide-field optical coherence tomography angiography Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Meng Tian, Guodong Zeng, Martin Zinkernagel, Christoph Tappeiner, Sebastian Wolf, Marion R Munk
Purpose To evaluate choriocapillaris (CC) and choroidal vascular changes in patients with posterior uveitis using swept-source (SS) wide-field optical coherence tomography angiography (OCTA). Method Consecutive patients with posterior uveitis were evaluated using 3×3 mm and 12×12 mm OCTA scan patterns and montage images of 5×12×12 mm or 2×15×9 mm, covering approximately 70°–90° of the retina. The images
-
Incidence and multimodal imaging characteristics of macular neovascularisation subtypes in Chinese neovascular age-related macular degeneration patients Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Yining Zhang, Yuhong Gan, Yunkao Zeng, Xuenan Zhuang, Xiongze Zhang, Yuying Ji, Yongyue Su, Feng Wen
Aims To investigate the incidence of macular neovascularisation (MNV) subtypes of neovascular age-related macular degeneration (nAMD) and summarise these subtypes’ clinical features in the Chinese population using multimodal imaging. Methods We retrospectively analysed 506 consecutive treatment-naïve nAMD patients (582 eyes). Incidence of MNV subtypes and clinical features were recorded based on their
-
Acute posterior multifocal placoid pigment epitheliopathy: clinical presentation and risk of stroke and transient ischaemic attack Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Rachael L Niederer, Priya D Samalia, Yi-Hsing Chen, Jonathan KS Goh, Elisa Eleanor Cornish, Stephen Guest, Peter J McCluskey, Lyndell L Lim, Joanne L Sims, Susan Lightman, Oren Tomkins-Netzer
Background/aims Acute posterior multifocal placoid pigment epitheliopathy is a rare but important disease that can be associated with life-threatening complications due to cerebral vasculitis. The primary objective was to determine the incidence of neurological complications and risk factors for stroke and transient ischaemic attack (TIA) associated with acute posterior multifocal placoid pigment epitheliopathy
-
Sympathetic nervous system activity is associated with choroidal thickness and axial length in school-aged children Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Senlin Lin, Bijun Zhu, Ting Wang, Hong Wang, Xian Xu, Shanshan Wang, Yao Yin, Zhaoyu Xiang, Yu Qian, Zhang Zhang, Lipu Cui, Haidong Zou, Xiangui He, Jianfeng Zhu, Yingyan Ma
Background/aims We aim to explore the effect of sympathetic nervous system (SNS) on choroid thickness (ChT) and axial length (AL). Methods Students of grade 2 and 3 from a primary school were included and followed for 1 year. Visual acuity, refraction, AL and ChT were measured. Morning urine samples were collected for determining SNS activity by analysing concentrations of epinephrine, norepinephrine
-
Pathologic myopia in highly myopic patients with high axial anisomyopia Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Jonathan Li, Yee Shan Dan, Si Qi Chua, Qiu Ying Wong, Rachel S Chong, Marcus Ang, SNEC Retina Group, Chee Wai Wong, Quan V Hoang
Purpose To determine prevalence of anisomyopia (axial length (AL) difference ≥2.5 mm) among high myopes ((HMs), defined by spherical equivalent of ≤6.0 diopters or AL ≥ 26.5 mm). To characterise the shorter anisomyopic eye (SAE) and evaluate if pathologic myopia (PM) in the longer anisomyopic eye (LAE) was associated with increased risk of PM in the SAE. Methods 1168 HMs were recruited from Singapore
-
Ensemble of deep convolutional neural networks is more accurate and reliable than board-certified ophthalmologists at detecting multiple diseases in retinal fundus photographs Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Prashant U Pandey, Brian G Ballios, Panos G Christakis, Alexander J Kaplan, David J Mathew, Stephan Ong Tone, Michael J Wan, Jonathan A Micieli, Jovi C Y Wong
Aims To develop an algorithm to classify multiple retinal pathologies accurately and reliably from fundus photographs and to validate its performance against human experts. Methods We trained a deep convolutional ensemble (DCE), an ensemble of five convolutional neural networks (CNNs), to classify retinal fundus photographs into diabetic retinopathy (DR), glaucoma, age-related macular degeneration
-
Application of artificial intelligence system for screening multiple fundus diseases in Chinese primary healthcare settings: a real-world, multicentre and cross-sectional study of 4795 cases Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Chufeng Gu, Yujie Wang, Yan Jiang, Feiping Xu, Shasha Wang, Rui Liu, Wen Yuan, Nurbiyimu Abudureyimu, Ying Wang, Yulan Lu, Xiaolong Li, Tao Wu, Li Dong, Yuzhong Chen, Bin Wang, Yuncheng Zhang, Wen Bin Wei, Qinghua Qiu, Zhi Zheng, Deng Liu, Jili Chen
Background/aims This study evaluates the performance of the Airdoc retinal artificial intelligence system (ARAS) for detecting multiple fundus diseases in real-world scenarios in primary healthcare settings and investigates the fundus disease spectrum based on ARAS. Methods This real-world, multicentre, cross-sectional study was conducted in Shanghai and Xinjiang, China. Six primary healthcare settings
-
Deep segmentation of OCTA for evaluation and association of changes of retinal microvasculature with Alzheimer’s disease and mild cognitive impairment Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Jianyang Xie, Quanyong Yi, Yufei Wu, Yalin Zheng, Yonghuai Liu, Antonella Macerollo, Huazhu Fu, Yanwu Xu, Jiong Zhang, Ardhendu Behera, Chenlei Fan, Alejandro F Frangi, Jiang Liu, Qinkang Lu, Hong Qi, Yitian Zhao
Background Optical coherence tomography angiography (OCTA) enables fast and non-invasive high-resolution imaging of retinal microvasculature and is suggested as a potential tool in the early detection of retinal microvascular changes in Alzheimer’s Disease (AD). We developed a standardised OCTA analysis framework and compared their extracted parameters among controls and AD/mild cognitive impairment
-
Randomised controlled trial of adjunctive triamcinolone acetonide in eyes undergoing vitreoretinal surgery following open globe trauma: The ASCOT study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Edward J Casswell, Suzie Cro, Victoria R Cornelius, Philip J Banerjee, Tapiwa M Zvobgo, Rhiannon Tudor Edwards, Victory Ezeofor, Bethany Anthony, Syed Mohammed Shahid, Catey Bunce, Joanna Kelly, Caroline Murphy, Elizabeth Robertson, David Charteris
Background/aims To investigate the clinical effectiveness of adjunctive triamcinolone acetonide (TA) given at the time of vitreoretinal surgery following open globe trauma (OGT). Methods A phase 3, multicentre, double-masked randomised controlled trial of patients undergoing vitrectomy following OGT comparing adjunctive TA (intravitreal and subtenons) against standard care (2014–2020). The primary
-
Correlating somatic copy number alteration in aqueous humour cfDNA with chemotherapy history, eye salvage and pathological features in retinoblastoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Yingxiu Luo, Mingpeng Xu, Ludi Yang, Yiran Yao, Jesse L Berry, Liya Xu, Xuyang Wen, Xiaoyu He, Minglei Han, Xianqun Fan, Jiayan Fan, Renbing Jia
This study determined to probe the potential association between somatic copy number alteration (SCNA) in retinoblastoma (RB) aqueous humour (AH) and pathological high-risk factors, clinical features and previous chemotherapy history. Methods Single-centre retrospective cohort study from including 58 AH samples collected from 58 patients diagnosed. Among them, 41 samples were collected after enucleation
-
Impact of tumour volume and treatment delay on the outcome after linear accelerator-based fractionated stereotactic radiosurgery of uveal melanoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Shanthala Sreenivasa, Markus Wösle, Yann Gager, Dirk Vordermark, Luise Grajewski, Lothar Krause, I. Frank Ciernik
Background/aims Primary radiation therapy is used to treat malignant uveal melanoma (UM). We report our single-centre experience with fractionated radiosurgery (fSRS) with a linear accelerator (LINAC) after specific adaptation for small target volumes with HybridArc. Methods From October 2014 to January 2020, 101 patients referred to Dessau City Hospital with unilateral UM underwent fSRS with 50 Gy
-
Orbital and periocular complications in patients with sinonasal tumours with orbital invasion Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Jiawei Zhao, Xinyang Jiang, Ehab Hanna, Shirley Y Su, Amy Moreno, Brandon Gunn, Steven Jay Frank, Renata Ferrarotto, Jing Ning, Bita Esmaeli
Aims The purpose of this study was to determine the frequency and associated risk factors of orbital/periocular complications in patients with sinonasal tumour with orbital invasion managed with eye-sparing treatments. Methods A retrospective case series of patients with primary sinonasal tumour with orbital invasion from January 2008 to December 2018. Patient factors were compared between the following
-
Validation of the East London Retinopathy of Prematurity algorithm to detect treatment-warranted retinopathy of prematurity: a cohort study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Sonia Moorthy, Gillian G W Adams, Graham Smith, Susmito Biswas, Waleed Aliyan, Roshni Bhudia, Aamir Saiyed, Shad Husain
Aim To validate the East London Retinopathy of Prematurity algorithm (EL-ROP) in a cohort of infants at risk of developing retinopathy of prematurity (ROP). Methods The EL-ROP algorithm was applied retrospectively to routinely collected data from two tertiary neonatal units in England on infants eligible for ROP screening. The EL-ROP recommendation, to screen or not, was compared with the development
-
Incidence of and risk factors for suspected and definitive glaucoma after bilateral congenital cataract surgery: a 5-year follow-up Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Jinghui Wang, Xianghua Wu, Qiwei Wang, Fengqi Zhou, Hui Chen, Wan Chen, Duoru Lin, Xiayin Zhang, Ruixin Wang, Jingjing Chen, Zhenzhen Liu, Zhuoling Lin, Xiaoyan Li, Jing Li, Ying Han, Yizhi Liu, Haotian Lin, Weirong Chen
Aims To report the incidence and associated risk factors for developing suspected and definitive glaucoma after bilateral congenital cataract (CC) removal with a 5-year follow-up. Methods Secondary analysis of a prospective longitudinal cohort study. Bilateral CC patients who had undergone cataract surgery between January 2011 and December 2014 at Zhongshan Ophthalmic Centre were recruited. Suspected
-
Self-reported dual sensory impairment and related factors: a European population-based cross-sectional survey Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-03-01 Nicolas Leveziel, Simon Marillet, Tasanee Braithwaite, Tunde Peto, Pierre Ingrand, Shahina Pardhan, Alain M Bron, Jost B Jonas, Serge Resnikoff, Little Julie Anne, Adrian C Davis, Catherine M McMahon, Rupert R A Bourne
Background Data on population-based self-reported dual vision and hearing impairment are sparse in Europe. We aimed to investigate self-reported dual sensory impairment (DSI) in European population. Methods A standardised questionnaire was used to collect medical and socio-economic data among individuals aged 15 years or more in 29 European countries. Individuals living in collective households or
-
Increased incidence of adult gonococcal keratoconjunctivitis at two tertiary eye hospitals in Western Europe: clinical features, complications and antimicrobial susceptibility Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-16 Alice L Milligan, Anna Randag, Sybren Lekkerkerk, Helen Fifer
Background Gonorrhoea is on the rise: between 2021 and 2022, a 50% and a 33% increase in diagnoses was seen, respectively, in England and the Netherlands. A concurrent rise in gonococcal keratoconjunctivitis (GKC) is a serious concern due to the potentially devastating visual complications. Methods This is a retrospective case series of adult GKC from two Western European tertiary ophthalmology centres
-
Continuous 24-hour intraocular pressure monitoring in normal Chinese adults using a novel contact lens sensor system Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-16 Yuning Zhang, Yifan Wei, Ching Hymn Christopher Lee, Ping Wai OR, Isuru Kaweendra Karunaratne, Mingjie Deng, Wenxin Yang, Iok Tong Chong, Yangfan Yang, Zidong Chen, Yanmei Fan, David C C Lam, Minbin Yu
Aims To investigate the physiological nyctohemeral intraocular pressure (IOP) rhythms of normal Chinese adults using a novel contact lens sensor system (CLS) that can output IOP in millimetres of mercury (mm Hg) continuously. Methods Fifty-nine eyes of 59 normal Chinese adults completed 24-hour IOP monitoring using the novel CLS. A descriptive analysis was conducted on the 24-hour IOP mean, peak and
-
Assessing the medical reasoning skills of GPT-4 in complex ophthalmology cases Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-16 Daniel Milad, Fares Antaki, Jason Milad, Andrew Farah, Thomas Khairy, David Mikhail, Charles-Édouard Giguère, Samir Touma, Allison Bernstein, Andrei-Alexandru Szigiato, Taylor Nayman, Guillaume A Mullie, Renaud Duval
Background/aims This study assesses the proficiency of Generative Pre-trained Transformer (GPT)-4 in answering questions about complex clinical ophthalmology cases. Methods We tested GPT-4 on 422 Journal of the American Medical Association Ophthalmology Clinical Challenges, and prompted the model to determine the diagnosis (open-ended question) and identify the next-step (multiple-choice question)
-
Variant and clinical landscape of Leber hereditary optic neuropathy based on 1516 families with mtDNA variants in a tertiary centre Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-12 Yuxi Zheng, Yingwei Wang, Yi Jiang, Junwen Wang, Shiqiang Li, Xueshan Xiao, Wenmin Sun, Panfeng Wang, Qingjiong Zhang, Xiaoyun Jia
Aims To investigate the clinical characteristics of Leber hereditary optic neuropathy (LHON) with mtDNA primary mutations to better understand features associated with prognosis. Methods This study enrolled 1540 LHON patients from 1516 unrelated families genetically confirmed by Sanger or whole-mitochondrial sequencing between 1997 and 2022. The spectrum of variants was summarised and compared in different
-
Conversion to faricimab after prior anti-vascular endothelial growth factor therapy for persistent diabetic macular oedema Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-12 Asad Farooq Durrani, Bita Momenaei, Taku Wakabayashi, Sudheshna Vemula, Saagar A Pandit, Jason Hsu, Allen C Ho, Marc J Spirn, Michael A Klufas, Sunir J Garg, James F Vander, Carl D Regillo, Allen Chiang, Ajay E Kuriyan, Yoshihiro Yonekawa
Background To assess the anatomical and functional outcomes in eyes with persistent diabetic macular oedema (pDME) on chronic anti-vascular endothelial growth factor therapy switched to intravitreal faricimab. Methods Patients with pDME on chronic anti-vascular endothelial growth factor therapy that were switched to faricimab and received at least three injections at our institution between April 2022
-
Is primary trabeculectomy cost-effective for patients with advanced primary open angle glaucoma? Results from the Treatment of Advanced Glaucoma Study economic model Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-09 Hosein Shabaninejad, Tara Homer, Ashleigh Kernohan, Anthony J King, Jennifer Burr, Augusto Azuara-Blanco, Luke Vale
Background/aims Advanced primary open angle glaucoma (POAG) is a lifelong condition. The aim of this study is to compare medical treatment against trabeculectomy for patients presenting with advanced POAG using an economic evaluation decision model. Methods A Markov model was used to compare the two treatments, medical treatment versus trabeculectomy for the management of advanced POAG, in terms of
-
Risk factors for development of hyper-reflective foci overlying drusen in eyes with intermediate age-related macular degeneration Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-07 Alireza Mahmoudi, Navid Manafi, Giulia Corradetti, Muneeswar Gupta Nittala, Mehdi Emamverdi, Stephanie Trejo Corona, Charles C Wykoff, David Sarraf, SriniVas R Sadda
Aims The aim of this study is to assess baseline characteristics of drusen preceding the development of intraretinal hyper-reflective foci (IHRF) in eyes with intermediate age-related macular degeneration (AMD). Methods In this retrospective case-control study, longitudinal optical coherence tomography (OCT) volume data from eyes with intermediate AMD in a retina clinic population were screened. All
-
Pan-Indian multicentre retrospective study of 0.01% atropine for myopia control Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-06 Jason C Yam, Yuzhou Zhang
The recent publication by Rohit et al evaluated the efficacy of 0.01% atropine in controlling myopia progression among Indian children over a 2-year period.1 A total of 732 myopic children aged 6–14 years from 20 centres were included, and all received 0.01% atropine eye-drops once daily. The authors found that, during the first year, there was a relative reduction of 64% in myopia progression, and
-
Prediction of retinopathy progression using deep learning on retinal images within the Scottish screening programme Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-05 Joseph Mellor, Wenhua Jiang, Alan Fleming, Stuart J McGurnaghan, Luke A K Blackbourn, Caroline Styles, Amos Storkey, Paul M McKeigue, Helen M Colhoun
Background/aims National guidelines of many countries set screening intervals for diabetic retinopathy (DR) based on grading of the last screening retinal images. We explore the potential of deep learning (DL) on images to predict progression to referable DR beyond DR grading, and the potential impact on assigned screening intervals, within the Scottish screening programme. Methods We consider 21 346
-
Functional vision disorder: a review of diagnosis, management and costs Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-02 Brendan Ka-Lok Tao, Jim Shenchu Xie, Edward Margolin
Functional vision disorder (FVD) is a relatively common diagnosis in ophthalmic practice which can be difficult to make because of clinician’s apprehension to miss organic pathology. We review the diagnostic approach to patients with FVD, organic mimics of FVD, its diagnostic and management strategies and associated cost burden. Patients with FVD typically present with visual acuity and/or field loss
-
Heterogeneity in disease activity, frequency of treatments, and visual outcomes among patients with retinal vein occlusion: relationship between injection need and vision with as-needed ranibizumab Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-01-30 Robert B Bhisitkul, Peter A Campochiaro, Steven Blotner, Carlos Quezada-Ruiz, Mimi Liu, Zdenka Haskova
Background/aims We characterised the relationships between monitoring frequency, ranibizumab injection need and vision in patients receiving as-needed (pro re nata; PRN) ranibizumab for macular oedema due to branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) in this post-hoc analysis of SHORE and HORIZON. Methods Patients aged 18 years and older with macular oedema due to
-
Imaging geographic atrophy: integrating structure and function to better understand the effects of new treatments Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-01-30 Stela Vujosevic, Anat Loewenstein, Louise O'Toole, Ursula Margarethe Schmidt-Erfurth, Dinah Zur, Usha Chakravarthy
Geographic atrophy (GA) is an advanced and irreversible form of age-related macular degeneration (AMD). Chronic low grade inflammation is thought to act as an initiator of this degenerative process, resulting in loss of photoreceptors (PRs), retinal pigment epithelium (RPE) and the underlying choriocapillaris. This review examined the challenges of clinical trials to date which have sought to treat
-
Low-dose atropine 0.01% for the treatment of childhood myopia: a pan-India multicentric retrospective study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-01-30 Rohit Saxena, Vinay Gupta, Rebika Dhiman, Elizabeth Joseph, Sumita Agarkar, R Neena, Damaris Magdalene, Jitendra Jethani, Sandra C Ganesh, Minal Patil, Pooja Gogri, Shailesh Gadaginamath, Pradhnya Sen, Jaspreet Sukhija, Deepak Mishra, Jyoti H Matalia, Anupam Sahu, Smita Kapoor, Shruti Nishanth, Shweta Chaurasia, Neelam Pawar, Nilutparna Deori, Viswanathan Sivaraman, Anamika Bordoloi, Shailja Tibrewal
Objective The objective of this study was to assess the efficacy of low-dose atropine 0.01% in controlling myopia progression among Indian children over a 2-year period. Methods This retrospective study, conducted across 20 centres in India, monitored the progression of myopia over 2 years after initiating treatment with 0.01% atropine eye drops. This included children between 6 and 14 years with baseline
-
Predictors of 24-month onset of macular fibrosis in type 3 macular neovascularisation Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-01-30 Paolo Forte, Vincenzo Fontana, Julia Muzio, Luca Di Cello, Paolo Corazza, Raffaella Rosa, Donatella Musetti, Aldo Vagge, Carlo Enrico Traverso, Massimo Nicolò
Aims To explore prognostic multimarker models for progression to macular fibrosis (MF) over 24 months specific to type 3 macular neovascularisation (T3 MNV). Methods This retrospective, exploratory, single-centre, cohort study comprised 65 eyes of 43 Caucasian patients with treatment naive T3 MNV, all with a 24-month follow-up post anti-VEGF therapy using a strict pro-re-nata (PRN) regimen. Data on
-
Two-year outcomes of different subretinal fluid drainage techniques during vitrectomy for fovea-off rhegmatogenous retinal detachments: ELLIPSOID-2 Study Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-01-30 Bryon R McKay, Aditya Bansal, Michael Kryshtalskyj, David T Wong, Alan R Berger, Rajeev H Muni
Background The purpose of the study is to compare visual acuity, complications and outer retinal integrity following subretinal fluid (SRF) drainage from the peripheral retinal breaks (PRBs) versus posterior retinotomy (PR) versus perfluorocarbon liquid (PFCL) for macula-off rhegmatogenous retinal detachments (RRDs) at 2 years post-surgery. Methods Retrospective analysis of 300 consecutive patients
-
High-risk factors for zonular complications during cataract surgery in eyes with pseudoexfoliation syndrome Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-01-30 Ken Hayashi, Motoaki Yoshida, Shin-ichi Manabe, Akira Hirata
Aims To predict high-risk factors for zonular complications during cataract surgery due to pre-existing severe zonular dehiscence in eyes with pseudoexfoliation (PXF) syndrome. Methods 315 eyes of 315 consecutive patients with PXF scheduled for phacoemulsification surgery underwent preoperative examination of various ocular parameters using an anterior segment-optical coherence tomography and other
-
At a glance Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-01 Frank Larkin
There have been considerable changes in conjunctival squamous cell carcinoma incidence rates over the course of the HIV epidemic in South Africa. Declining rates coincide with notable changes in the availability of effective antiretroviral therapy. Peak IOP, mean IOP, and IOP fluctuation are associated with faster rates of microvascular loss in the macula. Mean IOP is associated with faster rates of
-
Endophthalmitis rates and risk factors following intraocular surgeries: can we turn big-data benchmarks into patient benefit? Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-01 John Buchan
Chen et al present a study exploring postoperative endophthalmitis rates from the US Medicare Population from 2016 to 2019.1 They present postoperative infection rates for a range of intraocular procedures which are potentially very valuable for the process of informed consent, as well as functioning as benchmarks to permit individual departments to audit their own endophthalmitis rates. However, the
-
Risk factors for myopia among children and adolescents: an umbrella review of published meta-analyses and systematic reviews Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-01 Zhi-Qi Ying, Dan-Lin Li, Xin-Yu Zheng, Xiao-Feng Zhang, Chen-Wei Pan
Aims To identify potential risk factors for myopia in children and adolescents and assess the credibility of each evidence, providing reference for the development of myopia prevention strategies. Methods We searched PubMed, Web of Science and Embase databases from inception to April 2022 to find systematic reviews or meta-analyses investigating the relationship between potential risk factors and myopia
-
Incidence and epidemiology of conjunctival squamous cell carcinoma in relation to the HIV epidemic in South Africa: a 25-year analysis of the National Cancer Registry (1994–2018) Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-01 Kelsey Vernon Stuart, Daniel John Shepherd, Amy Lombard, Roland Hollhumer, Mazvita Muchengeti
Aims To describe the incidence and epidemiology of conjunctival squamous cell carcinoma (CSCC) in South Africa over a 25-year period (1994–2018), with particular reference to the HIV epidemic. Methods Incident cases of histologically diagnosed CSCC were identified from the pathology-based South African National Cancer Registry. Crude and direct age-standardised incidence rates (ASIRs) per 100 000 persons
-
Intraocular pressure increases the rate of macular vessel density loss in glaucoma Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-01 Golnoush Mahmoudinezhad, Sasan Moghimi, Takashi Nishida, Eleonora Micheletti, Kelvin H Du, Vahid Mohammadzadeh, Jo-Hsuan Wu, Alireza Kamalipour, Robert N Weinreb
Background/aims To evaluate the relationship over time between intraocular pressure (IOP) and the rate of macula whole image vessel density (wiVD) loss and whole image ganglion cell complex (wiGCC) thinning in glaucoma Methods From 62 patients in the Diagnostic Innovations in Glaucoma Study, 59 Primary open-angle glaucoma and 27 glaucoma suspect eyes with mean follow-up of 3.2 years were followed.
-
Decreased macular deep capillary plexus is associated with functional progression of normal tension glaucoma patients with unilateral visual field loss Br. J. Ophthalmol. (IF 4.1) Pub Date : 2024-02-01 Sigeng Lin, Xiao Shang, Xiaoyan Wang, Xizhong Chu, Chengju Hu, Yuqing Si, De-fu Chen, Weihe Zhou, Yu Xiang George Kong, Yuanbo Liang
Purpose To investigate whether quantitative optical coherence tomography angiography (OCTA) metrics of the superficial/deep macular retina are associated with the development of visual field (VF) loss in the fellow eyes of normal tension glaucoma (NTG) patients with unilateral VF loss. Methods A longitudinal study was conducted in which 61 eyes with normal VF (mean VF mean deviation −0.7±1.6 dB) from