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Proposal of the Need for New Korean Guidelines on the Use of Therapeutic Apheresis in Clinical Practice. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-11-01 Yousun Chung,Hyungsuk Kim,Dae-Hyun Ko
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Clinical Significance of Hemagglutination Grades Determined Using the IH-1000 Automated Blood Typing Instrument: Real-world Data. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-11-01 Bosung Park,Jin Seok Kim,Hee-Jeong Youk,Yousun Chung,Hyungsuk Kim,Sang-Hyun Hwang,Heung-Bum Oh,Dae-Hyun Ko
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The First Case of Prosthesis-related Infection Caused by Quambalaria cyanescens in Korea. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-11-01 Seok Ryun Kwon,Taek Soo Kim,Hyunwoong Park,Jae Hyeon Park
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Rare Gene Rearrangement t(11;22)(q23;q13)/KMT2A-EP300 in Therapy-related Acute Myeloid Leukemia: A Case Report. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-11-01 Seo Wan Kim,Seungjae Lee,Saeam Shin,Seung-Tae Lee
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Ex Vivo Expansion of Highly Cytotoxic Natural Killer Cells Using Optimal Culture Medium. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-11-01 Seokho Kim
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Age-specific Reference Intervals for Anti-Müllerian Hormone. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-11-01 Haeil Park
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Age Group-specific Reference Intervals for the Elecsys Anti-Müllerian Hormone Assay in Healthy Korean Women: a Nationwide Population-based Study. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Misuk Ji, Kwang-Rae Kim, Hyun-Ki Kim, Woochang Lee, Yeo-Min Yun, Sail Chun, Won-Ki Min
Anti-Müllerian hormone (AMH) is one of the most reliable markers of ovarian reserve. Automated AMH assays are widely used in clinical laboratories, but reference intervals for the Elecsys AMH assay for Asian populations have not yet been determined. We aimed to determine reference intervals in healthy Korean women.
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Practical Considerations for Clinical Laboratories in Top-down Approach for Assessing the Measurement Uncertainty of Clinical Chemistry Analytes. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Hyunjung Gu, Juhee Lee, Jinyoung Hong, Woochang Lee, Yeo-Min Yun, Sail Chun, Woo-In Lee, Won-Ki Min
The top-down (TD) approach using internal quality control (IQC) data is regarded a practical method for estimating measurement uncertainty (MU) in clinical laboratories. We estimated the MU of 14 clinical chemistry analytes using the TD approach and evaluated the effect of lot changes on the MU.
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Natural Killer Cell Expansion and Cytotoxicity Differ Depending on the Culture Medium Used. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Seung Kwon Koh, Jeehun Park, Seong-Eun Kim, Yuree Lim, Minh-Trang Thi Phan, Jinho Kim, Ilwoong Hwang, Yong-Oon Ahn, Sue Shin, Junsang Doh, Duck Cho
Adoptive cell therapy using umbilical cord blood (UCB)-derived allogeneic natural killer (NK) cells has shown encouraging results. However, because of the insufficient availability of NK cells and limited UCB volume, more effective culture methods are required. NK cell expansion and functionality are largely affected by the culture medium. While human serum is a major affecting component in culture
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Investigation of Discrepant ABO Blood Grouping Results from an Autoanalyzer. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Young Ae Lim, Seo-Jin Park, Hyun Soo Cho
A paucity of studies evaluating failed cases of ABO grouping using autoanalyzers exists. We investigated autoanalyzer rejected cases, including serologically suspicious ABO subgroups and discrepant ABO blood grouping results from Erytra Eflexis (Grifols, Spain), to demonstrate efficient use of autoanalyzers for ABO grouping.
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Predictors of Red Blood Cell Transfusion in Elderly COVID-19 Patients in Korea. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Hye Ryun Lee
Patients who experience clinical deterioration from coronavirus disease (COVID-19) require blood transfusion support. We analyzed blood component usage in COVID-19 patients and identified the predictors of red blood cell (RBC) transfusion in elderly (≥65 years) patients.
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Deciphering Epigenetic Backgrounds in a Korean Cohort with Beckwith-Wiedemann Syndrome. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Hwa Young Kim, Choong Ho Shin, Young Ah Lee, Chang Ho Shin, Gu-Hwan Kim, Jung Min Ko
Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth disorder caused by genetic or epigenetic alterations at two imprinting centers (ICs) in the 11p15.5 region. Delineation of the molecular defects is important for prognosis and predicting familial recurrence. We evaluated epigenetic alterations and potential epigenotype-phenotype correlations in Korean children with BWS.
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Immunohistochemical Staining to Identify Concomitant Systemic Mastocytosis in Acute Myeloid Leukemia with RUNX1::RUNX1T1. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Sang Mee Hwang, Beom Joon Kim, Jee-Soo Lee, Moon-Woo Seong, Soo Hyun Seo, Jin Ho Paik, Sang-A Kim, Ji Yun Lee, Jeong-Ok Lee, Yoon Hwan Chang, Soo Mee Bang
Systemic mastocytosis with associated hematological neoplasm (SM-AHN) poses diagnostic challenges because of the coexistence of atypical mast cell proliferation and hematological neoplasms. We assessed the presence of SM-AHN in patients with acute myeloid leukemia (AML) with RUNX1::RUNX1T1 from 2014 to 2020. Bone marrow (BM) samples were evaluated for mast cell aggregates using CD117 and CD25 immunohistochemical
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Molecular Epidemiology of Adenoviral Keratoconjunctivitis in Korea. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Jeong-Won Seo, Su Kyung Lee, In Hwan Hong, Se Hyun Choi, Joo Youn Lee, Han-Sung Kim, Hyun Soo Kim
Human adenoviruses (HAdVs) are a major cause of epidemic keratoconjunctivitis. We investigated the types of adenoviruses responsible for the recent epidemic of keratoconjunctivitis in Korea. From January to November 2019, 218 conjunctival swab samples were collected from patients clinically suspected as having adenoviral keratoconjunctivitis. Genotyping targeting of adenovirus capsid hexon genes was
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Immunogenicity of Third-dose BNT162b2 mRNA Vaccine Following Two Doses of ChAdOx1 in Health Care Workers: A Prospective Longitudinal Study. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-6-30 Jung-Ah Kim, Hae In Bang, Jeong Won Shin, Yoonhye Park, Saerom Kim, Mi-Young Kim, Eui Young Jang, Woo Yong Shin, Jieun Kim, Rojin Park, Tae Youn Choi
Following the original severe acute respiratory syndrome coronavirus 2 strain (Wuhan-Hu-1) in December 2019, the Delta variant in May 2021 and the Omicron variant in December 2021 were classified as variants of concern. The pandemic has been ongoing for more than two years, and the three-dose vaccination rate has reached approximately 50% in Korea. We analyzed anti-S antibodies (Abs) and neutralizing
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Investigation of the Neutralizing Antibody Response of Healthcare Workers at a Korean University Hospital Six Months After the Introduction of the COVID-19 Vaccine. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-09-01 Seong-Ho Choi,Ji Young Park,Joung Ha Park,Min-Chul Kim,Oh Joo Kweon,Jin-Won Chung
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Polyethylene Glycol Precipitation to Avoid Misdiagnosis of Insulin Autoimmune Syndrome: A Case Report and Testing Pathway in Medical Laboratories. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-09-01 Yuping Zeng,Guixing Li,Haolan Song
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Platelet Satellitism: Just a Laboratory Curiosity? A Case Report of Platelet Satellitism with Multilineage Involvement. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-09-01 Antonio La Gioia,Fabiana Fiorini,Marcello Fiorini
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Serial Analysis and Comparison of Mutation Profiles in Decitabine-treated Myeloid Sarcoma and Subsequent Acute Myeloid Leukemia Using Next-Generation Sequencing. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-09-01 Hee Sue Park,Seung Myoung Son,Jihyun Kwon
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Obtaining Reliable CBC Results in Clinical Laboratories. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-09-01 Seon Young Kim,Hyun Kyung Kim
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Review of the Use of Liquid Chromatography-Tandem Mass Spectrometry in Clinical Laboratories: Part II-Operations. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Brian A Rappold
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is increasingly utilized in clinical laboratories because it has advantages in terms of specificity and sensitivity over other analytical technologies. These advantages come with additional responsibilities and challenges given that many assays and platforms are not provided to laboratories as a single kit or device. The skills, staff, and assays
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An Objective Approach to Deriving the Clinical Performance of Autoverification Limits. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Tze Ping Loh, Rui Zhen Tan, Chun Yee Lim, Corey Markus
This study describes an objective approach to deriving the clinical performance of autoverification rules to inform laboratory practice when implementing them. Anonymized historical laboratory data for 12 biochemistry measurands were collected and Box-Cox-transformed to approximate a Gaussian distribution. The historical laboratory data were assumed to be error-free. Using the probability theory, the
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Clinical and Genomic Profiles of Korean Patients with MECOM Rearrangement and the t(3;21)(q26.2;q22.1) Translocation. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Jikyo Lee, Sung Min Kim, Soonok Kim, Jiwon Yun, Dajeong Jeong, Young Eun Lee, Eun-Youn Roh, Dong Soon Lee
The translocation (3;21)(q26.2;q22.1) is a unique cytogenetic aberration that characterizes acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) in patients with AML and myelodysplastic syndrome (MDS) or a therapy-related myeloid neoplasm. Using multigene target sequencing and FISH, we investigated the clinical and genomic profiles of patients with t(3;21) over the past 10 years. The
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Overexpression of Prohibitin 2 Protein is Associated with Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Young Eun Lee, Ha Jin Lim, Ju Heon Park, Hye Ran Kim, Min-Gu Kang, Young Kuk Cho, Jong Hee Shin, Myung Geun Shin
Cytogenetically normal acute myeloid leukemia (CN-AML) accounts for 40%-50% of all AML cases. Despite advances in understanding the molecular pathophysiology of CN-AML, its clinical outcome remains unsatisfactory and unpredictable. To investigate its clinical implication in CN-AML, we measured the expression of prohibitin 2 (PHB2) using immunohistochemical staining (IHCS) of paraffin-embedded bone
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Commutability Assessment of Processed Human Plasma Samples for Normetanephrine and Metanephrine Measurements Based on the Candidate Reference Measurement Procedure. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Yuhang Deng, Qingxiang Liu, Zhenni Liu, Haijian Zhao, Weiyan Zhou, Chuanbao Zhang
To identify candidate external quality assessment (EQA) materials for normetanephrine and metanephrine measurements, we assessed the commutability of eight processed human plasma samples. The agreement between routine assays and the candidate reference measurement procedure (cRMP) was also evaluated.
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Impact of Bicarbonate Interference on Routine Ion-Selective Electrode Chloride Measurements. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Tinne Monteyne, Matthijs Oyaert, Annelien Van Dalem, Maaike Godefroid, Matthias Cuykx, Nico Callewaert
Chloride measurement is crucial for calculating the anion gap. Bicarbonate can interfere with chloride measurements; however, there is no information on the specific types of electrodes affected or the changes in bicarbonate non-selectivity over time. We evaluated the interference of bicarbonate on chloride measurements using different electrodes and the stability of this interference over time.
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Clinical Utility of Next-Generation Flow-Based Minimal Residual Disease Assessment in Patients with Multiple Myeloma. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Hyun-Young Kim, In Young Yoo, Dae Jin Lim, Hee-Jin Kim, Sun-Hee Kim, Sang Eun Yoon, Seok Jin Kim, Duck Cho, Kihyun Kim
Minimal residual disease (MRD) is an important prognostic factor for evaluating a deeper treatment response in patients with multiple myeloma (MM). We evaluated the clinical utility of next-generation flow (NGF)-based MRD assessment in a heterogeneous MM patient population.
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Unreliable Automated Complete Blood Count Results: Causes, Recognition, and Resolution. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Gene Gulati, Guldeep Uppal, Jerald Gong
Automated hematology analyzers generate accurate complete blood counts (CBC) results on nearly all specimens. However, every laboratory encounters, at times, some specimens that yield no or inaccurate result(s) for one or more CBC parameters even when the analyzer is functioning properly and the manufacturer's instructions are followed to the letter. Inaccurate results, which may adversely affect patient
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Guidelines for Mobile Laboratories for Molecular Diagnostic Testing of COVID-19. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-4-27 Kyoung Ho Roh, Ki Ho Hong, Myung-Hyun Nam, Taek Soo Kim, Moon-Woo Seong, Jin Kyung Lee, Sookyoung Bae, Hee Jae Huh, Jeong-Yeal Ahn, Jinsook Lim, Gab Jung Kim, Jae Sun Park, Hyun Yeong Kim, Cheon Kwon Yoo, Hyukmin Lee, ,
With the rapid spread of the coronavirus disease (COVID-19), the need for rapid testing and diagnosis and consequently, the demand for mobile laboratories have increased. Despite this need, there are no clear guidelines for the operation, maintenance, or quality control of mobile laboratories. We provide guidelines for the operation, management, and quality control of mobile laboratories, and specifically
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Whole-genome Sequencing Reveals a Novel Structural Variant of CCDC39 in a Term Neonate with Primary Ciliary Dyskinesia. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-07-01 Jun Hee Shin,Sae-Mi Lee,Hyun Ho Kim,Jin Kyu Kim
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Three Cases of False-positive Multiplex Ligation-dependent Probe Amplification of BRCA1. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-07-01 Kyoung Bo Kim,Sunggyun Park,Jung Sook Ha,Namhee Ryoo,Do-Hoon Kim
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The First Case of Azorhizobium caulinodans Bacteremia in a Patient with Leukemia. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-07-01 Jae Hyeon Park,Taek Soo Kim,Hyunwoong Park
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The First Case of Clostridium saudiense Bacteremia in a Patient with Hepatocellular Carcinoma. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-07-01 Eungjun Yoon,Tae Yeul Kim,Won Young Heo,Onkyun Kang,Hui-Jin Yu,Joon Hyeok Lee,Jae-Hoon Ko,Nam Yong Lee,Hee Jae Huh
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The First Case of Preauricular Fistular Abscess Caused by Peptoniphilus grossensis. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-07-01 Mutbyul Kim,Hyoshim Shin,Dong-Hyun Lee,Eun-Ha Koh,Jung-Hyun Byun
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The First Case of B-lymphoblastic Leukemia Associated With t(7;8)(q34;p11.2) and FGFR1 Rearrangement. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-07-01 Ha-Eun Cho,Yujin Han,Jae Joon Lee,Kyung Sun Park,Young Jin Kim,Sun Young Cho,Hoi Soo Yoon,Woo-In Lee,Tae Sung Park
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Performance Evaluation of the Abbott Alinity hs Blood Slide Maker/Stainer. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-07-01 Min-Sun Kwak,In-Hwa Jeong,Sung-Sook Cho,Kwang-Sook Woo,Jin-Yeong Han
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Performance of BD MAX Group B Streptococcus (GBS) Assay without Enrichment for the Detection of GBS. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Sewhan Um, Jaeyoung Her, Si Hyun Kim, Sae Am Song, Young Nam Kim, Jeong Hwan Shin
Group B streptococcus (GBS) is an important pathogen causing neonatal early-onset disease. We evaluated the diagnostic performance of BD Max GBS assay (Becton Dickinson, Franklin Lakes, NJ, USA) without enrichment (direct BDM) for detecting GBS using vaginal and rectal specimens in comparison with culture. In total, 716 specimens collected from 358 pregnant women between June 2018 and May 2020 were
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Performance Evaluation of the PowerChek SARS-CoV-2, Influenza A & B Multiplex Real-Time PCR Kit in Comparison with the BioFire Respiratory Panel. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Tae Yeul Kim, Ji-Youn Kim, Hyang Jin Shim, Sun Ae Yun, Ja-Hyun Jang, Hee Jae Huh, Jong-Won Kim, Nam Yong Lee
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and influenza viruses may pose enormous challenges to our healthcare system. We evaluated the performance of the PowerChek SARS-CoV-2, Influenza A & B Multiplex Real-time PCR Kit (PowerChek; Kogene Biotech, Seoul, Korea) in comparison with the BioFire Respiratory Panels 2 and 2.1 (RP2 and RP2.1; bioMérieux, Marcy l'Étoile, France), using
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Performance Evaluation of the i-SmartCare 10 Analyzer and Method Comparison of Six Point-of-Care Blood Gas Analyzers. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Sang-Mi Kim, Hyung-Doo Park
Blood gas, electrolyte, glucose, and lactate level measurement have an immediate and critical impact on patient care. We evaluated the performance of i-SmartCare 10 (i-SENS Inc., Seoul, Korea) and conducted a method comparison study of five point-of-care (POC) analyzers with i-SmartCare 10 as the comparator, according to the CLSI guidelines. Ten analytes (pH, pCO2, pO2, Na+, K+, Cl-, iCa2+, glucose
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Erythroid Differentiation of Induced Pluripotent Stem Cells Co-cultured with OP9 Cells for Diagnostic Purposes. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Juhye Roh, Sinyoung Kim, June-Won Cheong, Su-Hee Jeon, Hyun-Kyung Kim, Moon Jung Kim, Hyun Ok Kim
Reagent red blood cells (RBCs) are prepared from donated whole blood, resulting in various combinations of blood group antigens. This inconsistency can be resolved by producing RBCs with uniform antigen expression. Induced pluripotent stem cells (iPSCs) generated directly from mature cells constitute an unlimited source for RBC production. We aimed to produce erythroid cells from iPSCs for diagnostic
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Performance Evaluation of the Aptima Assays in Comparison with the cobas 6800 Assays for the Detection of HIV-1, HBV, and HCV in Clinical Samples. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Younhee Park, Juhye Roh, Sinyoung Kim
Accurate and consistent viral load (VL) quantitation of HIV type 1 (HIV-1), hepatitis B virus (HBV), and hepatitis C virus (HCV) is important for diagnosis and clinical monitoring. Assay results have to be concordant and compatible across laboratories. We evaluated the performance of three Aptima assays (Hologic, San Diego, CA, USA) and compared their VL values with corresponding cobas 6800 assay (Roche
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Comparing Genomic Characteristics of Streptococcus pyogenes Associated with Invasiveness over a 20-year Period in Korea. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Hyoshim Shin, Takashi Takahashi, Seungjun Lee, Eun Hwa Choi, Takahiro Maeda, Yasuto Fukushima, Sunjoo Kim
Few studies have investigated the invasiveness of Streptococcus pyogenes based on whole-genome sequencing (WGS). Using WGS, we determined the genomic features associated with invasiveness of S. pyogenes strains in Korea.
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Current Status of Serum Insulin and C-Peptide Measurement in Clinical Laboratories: Experience from 94 Laboratories in China. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Weiyan Zhou, Yuhang Deng, Haijian Zhao, Chuanbao Zhang
Accurate measurements of serum insulin and C-peptide are needed for the therapy and classification of diabetes. This study investigated the status of serum insulin and C-peptide measurements in China by analyzing the results of five pooled serum samples measured in 94 laboratories.
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Sex-Specific U-Shaped Relationships Between High-Density Lipoprotein Cholesterol Levels and 10-year Major Adverse Cardiovascular Events: A Nationwide Cohort Study of 5.7 Million South Koreans. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Hyun Suk Yang, Ho Jin Jeong, Hyeongsu Kim, Hweung Kon Hwang, Mina Hur, Seungho Lee
High-density lipoprotein cholesterol (HDL-C) is a well-known predictor of atherosclerotic cardiovascular diseases (ASCVD). We explored the relationships between HDL-C levels and 10-year major adverse cardiovascular events (MACE) and provided sex-specific upper reference limits for HDL-C levels.
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Prognostic Utility of Procalcitonin, Presepsin, and the VACO Index for Predicting 30-day Mortality in Hospitalized COVID-19 Patients. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Mikyoung Park, Mina Hur, Hanah Kim, Chae Hoon Lee, Jong Ho Lee, Hyung Woo Kim, Minjeong Nam
Biomarkers and clinical indices have been investigated for predicting mortality in patients with coronavirus disease (COVID-19). We explored the prognostic utility of procalcitonin (PCT), presepsin, and the Veterans Health Administration COVID-19 (VACO) index for predicting 30-day-mortality in COVID-19 patients.
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Digital Morphology Analyzer Sysmex DI-60 vs. Manual Counting for White Blood Cell Differentials in Leukopenic Samples: A Comparative Assessment of Risk and Turnaround Time. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Minjeong Nam, Sumi Yoon, Mina Hur, Gun Hyuk Lee, Hanah Kim, Mikyoung Park, Hyeong Nyeon Kim
Digital morphology (DM) analyzers are increasingly being used for white blood cell (WBC) differentials. We assessed the laboratory efficiency of the Sysmex DI-60 system (DI-60; Sysmex, Kobe, Japan) in comparison with manual counting in leukopenic samples.
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Update of Guidelines for Laboratory Diagnosis of COVID-19 in Korea. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-2-19 Ki Ho Hong, Gab Jung Kim, Kyoung Ho Roh, Heungsup Sung, Jaehyeon Lee, So Yeon Kim, Taek Soo Kim, Jae-Sun Park, Hee Jae Huh, Younhee Park, Jae-Seok Kim, Hyun Soo Kim, Moon-Woo Seong, Nam Hee Ryoo, Sang Hoon Song, Hyukmin Lee, Gye Cheol Kwon, Cheon Kwon Yoo
Korean Society for Laboratory Medicine and the Korea Disease Prevention and Control Agency have announced guidelines for diagnosing coronavirus disease (COVID-19) in clinical laboratories in Korea. With the ongoing pandemic, we propose an update of the previous guidelines based on new scientific data. This update includes recommendations for tests that were not included in the previous guidelines,
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The First Korean Case of Griscelli Syndrome Type 2 With Hemophagocytic Lymphohistiocytosis and Partial Albinism. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-05-01 Youngeun Lee,Hyun Jin Park,Hyoung Jin Kang,Jung Min Ko,Boram Kim,Yoon Hwan Chang,Hyun Kyung Kim,Jee-Soo Lee,Man Jin Kim,Sung Sup Park,Moon-Woo Seong
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RNA Sequencing Provides Evidence for Pathogenicity of a Novel CHEK2 Splice Variant (C.1009-7T>G). Ann. Lab. Med. (IF 4.941) Pub Date : 2022-05-01 Rae Na,Jinyoung Hong,Hyunjung Gu,Woochang Lee,Jae-Lyun Lee,Sail Chun,Won-Ki Min
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RNA Sequencing for Elucidating an Intronic Variant of Uncertain Significance (SDHD c.314+3A>T) in Splicing Site Consensus Sequences. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-05-01 Hyunjung Gu,Jinyoung Hong,Woochang Lee,Sung-Bae Kim,Sail Chun,Won-Ki Min
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Skewed X-Chromosome Inactivation in a Korean Girl with Severe Mucopolysaccharidosis Type II. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-05-01 Hwa Young Kim,Man Jin Kim,Moon-Woo Seong,Jung Min Ko
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Invasive Hormographiella aspergillata Infection Identified Using DNA Sequencing. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-05-01 Eunbin Chong,Hui-Jin Yu,Tae Yeul Kim,Keon Hee Yoo,Yae-Jean Kim,Hee Jae Huh,Nam Yong Lee
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Incidence Evaluation of SARS-CoV-2 Variants in the Ulsan Area, Korea, Using PowerChek SARS-CoV-2 S-gene Mutation Detection Kit: A Pilot Study. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-05-01 Sang Hyuk Park,Hyun-Ki Kim,Hang Kang,Jung Heon Kim,Jaeseung Lee,Ji-Hun Lim,Seon-Ho Lee,Joseph Jeong
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Active Surveillance for Carbapenem-resistant Enterobacteriaceae at a Single Center for Four Years. Ann. Lab. Med. (IF 4.941) Pub Date : 2022-05-01 Inho Choi,Yangsoon Lee
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Substantial Improvement in Nontuberculous Mycobacterial Identification Using ASTA MicroIDSys Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry with an Upgraded Database. Ann. Lab. Med. (IF 4.941) Pub Date : 2021-12-16 Junhyup Song, Shinyoung Yoon, Yongha In, Daewon Kim, Hyukmin Lee, Dongeun Yong, Kyoungwon Lee
Identifying Mycobacterium using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is challenging. We evaluated the performance of MALDI-TOF MS in identifying nontuberculous mycobacteria (NTM) using the ASTA MicroIDSys system (ASTA Inc., Suwon, Korea) with the MycoDB v1.95s and upgraded MycoDB v2.0-beta databases. We tested 124 NTM isolates collected from Ogawa
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Genetic Counseling and Long-Term Surveillance Using a Multidisciplinary Approach in von Hippel-Lindau Disease. Ann. Lab. Med. (IF 4.941) Pub Date : 2021-12-16 Sun Joo Yoon, Won Kyung Kwon, Geehay Hong, Ja-Hyun Jang, Byong Chang Jeong, Jae Hyeon Kim, Jong-Won Kim
von Hippel-Lindau (VHL) disease is an autosomal dominant disorder caused by variants of the VHL tumor suppressor gene (VHL). Early detection and treatment are essential to prevent morbidity and mortality. We evaluated the effectiveness of surveillance strategies and the utility of a VHL clinic with a multidisciplinary team for the first time in Korea.
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Questionnaire Survey on Current Red Blood Cell Transport and Storage in Korea for Reducing Wastage. Ann. Lab. Med. (IF 4.941) Pub Date : 2021-12-16 Mikyoung Park, Mina Hur, Hahah Kim, Kyungmi Oh, Hyunmi Kim, Young Hye Song, Dae-Hyun Ko, Yousun Chung
To ensure safe red blood cell (RBC) transfusion practice, it is important to comply with storage and transport requirements of RBC units. We conducted a comprehensive survey on the practice of RBC transport and storage to explore the awareness of and compliance with the 30-minute rule, the current status of RBC unit transport, and possible utility of temperature indicators (TIs) to reduce RBC wastage
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Effect of Outlier Elimination on the 99th Percentile Upper Reference Limits of High-Sensitivity Cardiac Troponin I Assays Based on a Strictly Selected Healthy Reference Population. Ann. Lab. Med. (IF 4.941) Pub Date : 2021-12-16 Sunyoung Ahn, Hyun-Ki Kim, Woochang Lee, Sail Chun, Won-Ki Min
We established high-sensitivity cardiac troponin I (hsTnI) 99th percentile upper reference limits (URLs) for the Centaur XPT High-Sensitivity Troponin I assay (Centaur hsTnI; Siemens, Erlangen, Germany) and Atellica IM High-Sensitivity Troponin I assay (Atellica hsTnI; Siemens) and assessed the effect of outlier elimination.
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Promotion to Top-Tier Journal and Development Strategy of the Annals of Laboratory Medicine for Strengthening its Leadership in the Medical Laboratory Technology Category: A Bibliometric Study. Ann. Lab. Med. (IF 4.941) Pub Date : 2021-12-16 Sun Huh
A bibliometric analysis of the Annals of Laboratory Medicine (ALM) was performed to understand its position in the medical laboratory technology category and to suggest a developmental strategy.
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Current Issues, Challenges, and Future Perspectives of Genetic Counseling in Korea. Ann. Lab. Med. (IF 4.941) Pub Date : 2021-12-16 Namhee Kim, Sun-Young Kong, Jongha Yoo, Do-Hoon Kim, Soo Hyun Seo, Jieun Kim
Genetic testing has become increasingly integrated into all areas of healthcare, and complex genetic testing usage continues to grow; thus, the demand for genetic counseling (GC) is likely to increase. However, it is unclear whether the current clinical GC capacity is sufficient for meeting the existing demand. This review describes the current issues, challenges, and future perspectives of GC in Korea