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Exploring Renal Function Assessment: Creatinine, Cystatin C, and Estimated Glomerular Filtration Rate Focused on the European Kidney Function Consortium Equation. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-11-01 Hans Pottel,Pierre Delanaye,Etienne Cavalier
Serum creatinine and serum cystatin C are the most widely used renal biomarkers for calculating the estimated glomerular filtration rate (eGFR), which is used to estimate the severity of kidney damage. In this review, we present the basic characteristics of these biomarkers, their advantages and disadvantages, some basic history, and current laboratory measurement practices with state-of-the-art methodology
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Primary Hyperoxaluria Screening and Monitoring: Quantitative Measurement of Plasma Oxalate by Gas Chromatography-Mass Spectrometry With High Sensitivity. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-31 Mehrdad Yazdanpanah,Jessie Cameron,Chandra Chappel,Libin Yuan
Background Plasma oxalate measurements can be used for the screening and therapeutic monitoring of primary hyperoxaluria. We developed a gas chromatography-mass spectrometry (GC-MS) assay for plasma oxalate measurements with high sensitivity and suitable testing volumes for pediatric populations. Methods Plasma oxalate was extracted, derivatized, and analyzed by GC-MS. We measured the ion at m/z 261
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Evaluation of a Modified Protocol for the SepsiPrep Kit for Direct Identification and Antimicrobial Susceptibility Testing From Positive Blood Culture Using BACTEC Plus and BacT/Alert Blood Culture Bottles. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-30 In Young Yoo,Sung Il Ha,Hee Jae Huh,Tae Yeul Kim,Hyang Jin Shim,Hyeyoung Lee,Jayoung Kim,Nam Yong Lee,Yeon-Joon Park
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Identification of Potential Genomic Alterations Using Pan-Cancer Cell-Free DNA Next-Generation Sequencing in Patients With Gastric Cancer. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-30 Boyeon Kim,Yoonjung Kim,Jae Yong Cho,Kyung-A Lee
Background Molecular cancer profiling may lead to appropriate trials for molecularly targeted therapies. Cell-free DNA (cfDNA) is a promising diagnostic and/or prognostic biomarker in gastric cancer (GC). We characterized somatic genomic alterations in cfDNA of patients with GC. Methods Medical records and cfDNA data of 81 patients diagnosed as having GC were reviewed. Forty-nine and 32 patients were
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Head-to-Head Comparison of Nine Assays for the Detection of Anti-Echinococcus Antibodies: A Retrospective Evaluation. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-26 Carolina Mattwich,Kristina Huber,Gisela Bretzel,Sebastian Suerbaum,Andreas Wieser,Karl Dichtl
Background Echinococcosis is a neglected tropical disease that is severely underdiagnosed in resource-limited settings. In developed countries, diagnosing echinococcosis is challenging, and reliable serological assays are urgently needed. In the Central European Alps, EM is more common than EG; however, data on the diagnostic performance of assays for EM cases are scarce. We evaluated the suitability
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The Use of Bone-Turnover Markers in Asia-Pacific Populations. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-23 Samuel Vasikaran,Subashini C Thambiah,Rui Zhen Tan,Tze Ping Loh,
Bone-turnover marker (BTM) measurements in the blood or urine reflect the bone-remodeling rate and may be useful for studying and clinically managing metabolic bone diseases. Substantial evidence supporting the diagnostic use of BTMs has accumulated in recent years, together with the publication of several guidelines. Most clinical trials and observational and reference-interval studies have been performed
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A Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneously Determining Meropenem and Linezolid in Blood and Cerebrospinal Fluid. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-23 Joanna Berska,Jolanta Bugajska,Krystyna Sztefko
Antibiotic therapy requires appropriate dosage of drugs for effective treatment. Too low antibiotic concentrations may lead to treatment failure and the development of resistant pathogens, whereas overdosing may cause neurological side effects or hemolytic diseases. Meropenem and linezolid are used only in the treatment of serious infections or when other antibiotics are no longer effective as well
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Concurrent Pleural and Pericardial Involvement in a Patient With De Novo Pure Erythroid Leukemia. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-16 Yun Zhang,Kechao Li,Xue Li,Hui Wang,Ting Li,Fang Long
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Re-evaluation of a Fibrillin-1 Gene Variant of Uncertain Significance Using the ClinGen Guidelines. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-16 Seo Wan Kim,Boyeon Kim,Yoonjung Kim,Kyung-A Lee
Background Marfan syndrome (MFS) is caused by fibrillin-1 gene (FBN1) variants. Mutational hotspots and/or well-established critical functional domains of FBN1 include cysteine residues, calcium-binding consensus sequences, and amino acids related to interdomain packaging. Previous guidelines for variant interpretation do not reflect the features of genes or related diseases. Using the Clinical Genome
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Reverse Transcription-PCR-based Sanger Sequencing-confirmed Exon-skipping Effect of a Novel GEN1 Intronic Variant (c.1408+4A>G). Ann. Lab. Med. (IF 4.9) Pub Date : 2023-10-16 Jiyeon Kim,Joonsang Yu,Seunghoo Lee,Sollip Kim,In-Seob Lee,Woochang Lee,Sail Chun
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Predictive Performance of Neutrophil Gelatinase Associated Lipocalin, Liver Type Fatty Acid Binding Protein, and Cystatin C for Acute Kidney Injury and Mortality in Severely Ill Patients. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-26 Ayu Asakage, Shiro Ishihara, Louis Boutin, François Dépret, Takeshi Sugaya, Naoki Sato, Etienne Gayat, Alexandre Mebazaa, Benjamin Deniau
Acute kidney injury (AKI) is a common condition in severely ill patients associated with poor outcomes. We assessed the associations between urinary neutrophil gelatinase-associated lipocalin (uNGAL), urinary liver-type fatty acid-binding protein (uLFABP), and urinary cystatin C (uCysC) concentrations and patient outcomes.
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Identification of Two Novel ANKRD11 Mutations: Highlighting Incomplete Penetrance in KBG Syndrome. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Nada Amllal,Siham Chafai Elalaoui,Maria Zerkaoui,Amal Chiguer,Lamia Afif,Amal Thimou Izgua,Abdelaziz Sefiani,Jaber Lyahyai
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Effectiveness of Unified Computerized Reporting of Point-of-Care Glucose Meter Test. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Sooin Choi,Dughyun Choi,Soo Jeong Choi,Jin Kuk Kim,You Kyoung Lee,Yong-Wha Lee
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In Vitro Activity of Benzimidazole (SPR719) Against Clinical Isolates of Nontuberculous Mycobacteria With and Without Clarithromycin or Amikacin Resistance. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Dae Hun Kim,Sungmin Zo,Su-Young Kim,Byung Woo Jhun
Limited data are available regarding the in vitro activity of SPR719, a derivative of benzimidazole, against diverse nontuberculous mycobacteria (NTM) species. We investigated the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of SPR719 against clinical NTM isolates, including clarithromycin- and amikacin-resistant strains. NTM isolates were obtained from patients
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The First Korean Hemoglobinopathy With Unique Hemoglobin Electrophoresis Results Diagnosed as Hemoglobin Boras. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Jeongyun Bae,Won Kee Ahn,Jaehyeok Jang,Hanmil Jang,Hyein Kang,John Hoon Rim,Seung Min Hahn,Jung Woo Han,Chuhl Joo Lyu,Jong-Baeck Lim
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Skeletal Muscle Mass Measurement via Bioelectrical Impedance Analysis as an Aid to Screen for Chronic Kidney Disease in Routine Health Checkups. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Seunghoo Lee,Sangpil Yoon,Sollip Kim,Woochang Lee,Sail Chun,Won-Ki Min
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Preventing Blood Transfusion Errors: How Personal Digital Assistants Can Improve Patient Safety. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Eunhui Ji,Kae Lyang Koo,Hyun Ki Min,Sun Min Lee,Seung-Hwan Oh,Hyun Ji Lee
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Clinical Usefulness of a Cell-based Assay for Detecting Myelin Oligodendrocyte Glycoprotein Antibodies in Central Nervous System Inflammatory Disorders. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Jin Myoung Seok,Patrick Waters,Mi Young Jeon,Hye Lim Lee,Seol-Hee Baek,Jin-Sung Park,Sa-Yoon Kang,Ohyun Kwon,Jeeyoung Oh,Byung-Jo Kim,Kyung-Ah Park,Sei Yeul Oh,Byoung Joon Kim,Ju-Hong Min
Background The clinical implications of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Abs) are increasing. Establishing MOG-Ab assays is essential for effectively treating patients with MOG-Abs. We established an in-house cell-based assay (CBA) to detect MOG-Abs to identify correlations with patients' clinical characteristics. Methods We established the CBA using HEK 293 cells transiently
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Prediction of Mid-term Platelet Transfusion in Stable Trauma Patients Using Rotational Thromboelastometry. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Ha Jin Lim,Hyunseok Jang,Naa Lee,Euisung Jeong,Yunchul Park,Younggoun Jo,Jungchul Kim,Young Eun Lee,Hyun-Jung Choi,Seung-Jung Kee,Jong Hee Shin,Myung Geun Shin
Background Rotational thromboelastometry (ROTEM; TEM International GmbH, Munich, Germany) is a global coagulation test that guides evidence-based platelet transfusion in trauma patients. We evaluated ROTEM parameters for predicting mid-term (five days) platelet transfusion in trauma patients. Methods Maximum clot firmness and clot amplitudes after 5, 10, and 15 mins (A5, A10, and A15, respectively)
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Association Between Low Anti-spike Antibody Levels After the Third Dose of SARS-CoV-2 Vaccination and Hospitalization due to Symptomatic Breakthrough Infection in Kidney Transplant Recipients. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Ahram Han,Sangil Min,Eun-Ah Jo,Hajeong Lee,Yong Chul Kim,Seung Seok Han,Hee Gyung Kang,Yo Han Ahn,Inseong Oh,Eun Young Song,Jongwon Ha
Background Whether anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody levels post-third coronavirus disease (COVID-19) vaccination correlate with worse outcomes due to breakthrough infection is unclear. We evaluated the association between anti-SARS-CoV-2 antibody levels and symptomatic breakthrough infection or hospitalization during the Omicron surge in kidney transplant recipients
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Comparative Genomic Analysis of Staphylococcal Cassette Chromosome mec Type V Staphylococcus aureus Strains and Estimation of the Emergence of SCCmec V Clinical Isolates in Korea. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Takashi Takahashi,Hyaekang Kim,Han-Sung Kim,Hyun Soo Kim,Wonkeun Song,Jae-Seok Kim
Background Staphylococcal cassette chromosome mec type V (SCCmec V) methicillin-resistant Staphylococcus aureus (MRSA) has been recovered from patients and livestock. Using comparative genomic analyses, we evaluated the phylogenetic emergence of SCCmec V after transmission from overseas donor strains to Korean recipient strains. Methods Sixty-three complete MRSA SCCmec V genomes (including six Korean
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Changing Genotypic Distribution, Antimicrobial Susceptibilities, and Risk Factors of Urinary Tract Infection Caused by Carbapenemase-Producing Pseudomonas aeruginosa. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Seri Jeong,Kibum Jeon,Nuri Lee,Min-Jeong Park,Wonkeun Song
Background Carbapenem-resistant Pseudomonas aeruginosa (CrPA) is a leading cause of healthcare-associated urinary tract infections (UTIs). Carbapenemase production is an important mechanism that significantly alters the efficacy of frequently used anti-pseudomonal agents. Reporting the current genotypic distribution of carbapenemase-producing P. aeruginosa (CPPA) isolates in relation to antimicrobial
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Bias in Laboratory Medicine: The Dark Side of the Moon. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Abdurrahman Coskun
Physicians increasingly use laboratory-produced information for disease diagnosis, patient monitoring, treatment planning, and evaluations of treatment effectiveness. Bias is the systematic deviation of laboratory test results from the actual value, which can cause misdiagnosis or misestimation of disease prognosis and increase healthcare costs. Properly estimating and treating bias can help to reduce
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Evaluation of Group Genetic Counseling Sessions via a Metaverse-based Application. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Boeun Yoo,Arang Kim,Hye Sung Moon,Min-Kyung So,Tae-Dong Jeong,Kyoung Eun Lee,Byung-In Moon,Jungwon Huh
Background Group genetic counseling has been implemented to meet growing demand. A metaverse platform, in which a society is built and activities are carried out in the virtual world, has not yet been implemented in group genetic counseling. We investigated whether a metaverse platform could be an alternative service-delivery model for group genetic counseling. Methods Participants (N=131) were divided
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Ionized Magnesium Correlates With Total Blood Magnesium in Pediatric Patients Following Kidney Transplant. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Denise C Hasson,Shruthi Mohan,James E Rose,Kyle A Merrill,Stuart L Goldstein,Stefanie W Benoit,Charles D Varnell
Background Abnormal serum magnesium (Mg) concentrations are common and associated with worse mortality in kidney-transplant recipients. Many kidney and transplant-related factors affect Mg homeostasis. The concentration of the active form, ionized Mg (iMg), is not measured clinically, and total Mg (tMg) and iMg correlations have conflicted. We hypothesized that iMg and tMg concentrations show poor
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Challenges of Carbapenem-resistant Pseudomonas aeruginosa in Infection Control and Antibiotic Management. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Young Jin Kim,Hee Jae Huh,Heungsup Sung
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New Insights Into SARS-CoV-2-specific Antibody Levels in Kidney Transplantation Recipients After Three Vaccination Doses. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Hyunhye Kang,Eun-Jee Oh
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Comparison of Direct and Extraction Immunoassay Methods With Liquid Chromatography-Tandem Mass Spectrometry Measurement of Urinary Free Cortisol for the Diagnosis of Cushing's Syndrome. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-09-04 Danni Mu,Jiadan Fang,Songlin Yu,Yichen Ma,Jin Cheng,Yingying Hu,Ailing Song,Fang Zhao,Qi Zhang,Zhihong Qi,Kui Zhang,Liangyu Xia,Ling Qiu,Huijuan Zhu,Xinqi Cheng
Background Twenty-four-hour urinary free cortisol (UFC) measurement is the initial diagnostic test for Cushing's syndrome (CS). We compared UFC determination by both direct and extraction immunoassays using Abbott Architect, Siemens Atellica Solution, and Beckman DxI800 with liquid chromatography-tandem mass spectrometry (LC-MS/MS). In addition, we evaluated the value of 24-hr UFC measured by six methods
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ABO Blood Group Antigen Changes in Acute Myeloid Leukemia and No Significant Association With RUNX1 and GATA2 Somatic Variants. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 In Hwa Jeong,Ji Young Seo,Sooin Choi,Hyun-Young Kim,Duck Cho
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Variant Allele Frequency of Pseudogene-Related Variants in Short-read Next-Generation Sequencing Data May Mislead Genetic Diagnosis: A Case of Shwachman-Diamond Syndrome. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Heerah Lee,Jung Ae Lee,Hyesu Lee,Jee-Soo Lee,Jung Min Ko,Man Jin Kim,Moon-Woo Seong
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No Observed Interference by Nucleated Red Blood Cells in Total Bilirubin Measurement by Point-of-Care Testing: Six Years of Experience. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Estéfani Martínez Chávez,Paloma Oliver,Antonio Buño,Pilar Fernández-Calle
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Estradiol Testing in the Exploration of Early Onset Puberty: Comparison of RIA and Chemiluminescence Immunoassay. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Justine Blin,Clarisse Hochman,Nolwenn Graveline,Damien Masson,Sabine Baron,Kalyane Bach-Ngohou
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New Issues With Neutrophil Gelatinase-associated Lipocalin in Acute Kidney Injury. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Sun Young Cho,Mina Hur
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Improving the Work Efficiency of Therapeutic Drug Monitoring Reports Through the Establishment of an Automated Data Transfer System. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Seunghoo Lee,Sangpil Yoon,Hyun-Ki Kim,Sollip Kim,Woochang Lee,Sail Chun,Won-Ki Min
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Validation of High-sensitivity Flow Cytometry for Reliable Immune Cell Analysis in Real-world Laboratory Settings. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Hyunji Kim, Sung Shin, Sang-Hyun Hwang, Miyoung Kim, Young-Uk Cho, Seongsoo Jang
The adoption of high-sensitivity flow cytometry (HSFC) in routine laboratory settings has been slow owing to concerns regarding the reliability and reproducibility of results. Validation is an essential prerequisite for conducting assays, and implementing the CLSI guidelines has been confusing, primarily because many aspects are not yet established. We aimed to validate an HSFC protocol for detecting
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Cost-Effectiveness Analysis of Three Diagnostic Strategies for the Detection of EGFR Mutation in Advanced Non-Small Cell Lung Cancer. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Sun Mi Cho, Hye Sun Lee, Soyoung Jeon, Yoonjung Kim, Sun-Young Kong, Jin Kyung Lee, Kyung-A Lee
In non-small cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) mutation testing of tumor tissue should be conducted at diagnosis. Alternatively, circulating tumor DNA can be used to detect EGFR mutation. We compared the cost and clinical effect of three strategies according to the application of the EGFR test.
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Molecular and Clinical Features of Fluconazole Non-susceptible Candida albicans Bloodstream Isolates Recovered in Korean Multicenter Surveillance Studies. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Min Ji Choi, Yong Jun Kwon, Seung A Byun, Mi-Na Kim, Wee Gyo Lee, Jaehyeon Lee, Dongeun Yong, Chulhun L Chang, Eun Jeong Won, Soo Hyun Kim, Seung Yeob Lee, Jong Hee Shin
Acquired fluconazole resistance (FR) in bloodstream infection (BSI) isolates of Candida albicans is rare. We investigated the FR mechanisms and clinical features of 14 fluconazole non-susceptible (FNS; FR and fluconazole-susceptible dose-dependent) BSI isolates of C. albicans recovered from Korean multicenter surveillance studies during 2006-2021. Mutations causing amino acid substitutions (AASs) in
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Effect of Two Cystatin C Reagents and Four Equations on Glomerular Filtration Rate Estimations After Standardization. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Hyun-Seung Lee, Go-Eun Bae, Jung Eun Lee, Hyung-Doo Park
Serum cystatin C (cysC), which is less affected by sex, race, and muscle mass than creatinine, is a useful biomarker of the estimated glomerular filtration rate (eGFR). The standardization of cysC measurements remains controversial, although a certified reference material (ERM-DA471/IFCC) is available. Moreover, the effect of combinations of cysC reagents and equations for eGFR is unclear.
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Comparison of the New VITEK MS PRIME System with the Matrix-Assisted Laser Desorption Ionization Biotyper Microflex LT for the Identification of Microorganisms. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Patrick Grohs, Elodie Remaud, Cybill Lath, Kim Vuong, Marie-Lize Parolini, Eric Dannaoui, Isabelle Podglajen
Matrix-assisted laser desorption ionization (MALDI) is the cornerstone of bacterial identification. The performance of a new MALDI time-of-flight mass spectrometry VITEK MS PRIME (VMS-P) system was compared with that of the MALDI Biotyper Microflex LT (MBT) system, which is routinely used in our laboratory.
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Clot Waveform Analysis for Hemostatic Abnormalities. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Hideo Wada, Katsuya Shiraki, Takeshi Matsumoto, Hideto Shimpo, Motomu Shimaoka
Clot waveform analysis (CWA) observes changes in transparency in a plasma sample based on clotting tests such as activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT). Evidence indicates that not only an abnormal waveform but also peak times and heights in derivative curves of CWA are useful for the evaluation of hemostatic abnormalities. Modified CWA, including
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Neutrophil Gelatinase-Associated Lipocalin Cutoff Value Selection and Acute Kidney Injury Classification System Determine Phenotype Allocation and Associated Outcomes. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Annemarie Albert, Sebastian Radtke, Louisa Blume, Rinaldo Bellomo, Michael Haase, Philipp Stieger, Ulrich Paul Hinkel, Rüdiger C Braun-Dullaeus, Christian Albert
We explored the extent to which neutrophil gelatinase-associated lipocalin (NGAL) cutoff value selection and the acute kidney injury (AKI) classification system determine clinical AKI-phenotype allocation and associated outcomes.
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Comparison of Four T-cell Assays and Two Binding Antibody Assays in SARS-CoV-2 Vaccinees With or Without Omicron Breakthrough Infection. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Yeon Ju Seo, Inseong Oh, Minjeong Nam, Sue Shin, Eun Youn Roh, Eun Young Song
Several T-cell response assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are available; however, their comparability and correlations with antibody responses remain unclear. We compared four SARS-CoV-2 T-cell response assays and two anti-SARS-CoV-2 spike antibody assays.
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Evaluation of Vancomycin Area Under the Concentration-Time Curve Predictive Performance Using Bayesian Modeling Software With and Without Peak Concentration: An Academic Hospital Experience for Adult Patients Without Renal Impairment. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Hyun-Ki Kim, Tae-Dong Jeong
The revised U.S. consensus guidelines on vancomycin therapeutic drug monitoring (TDM) recommend obtaining trough and peak samples to estimate the area under the concentration-time curve (AUC) using the Bayesian approach; however, the benefit of such two-point measurements has not been demonstrated in a clinical setting. We evaluated Bayesian predictive performance with and without peak concentration
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Soluble Suppression of Tumorigenicity-2 as a Candidate Prognostic Marker for Stroke: A Systematic Review. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-06-30 Koohyar Ahmadzadeh, Shayan Roshdi Dizaji, Mohammad Balabandian, Hamzah Adel Ramawad, Mahmoud Yousefifard
Risk stratification of patients for incidence of stroke and its outcomes can aid in decision-making regarding treatment options and rehabilitative care. We systematically reviewed the literature to provide comprehensive evidence for the value of serum soluble suppression of tumorigenicity-2 (sST-2) in the prediction of stroke incidence and the evaluation of post-stroke outcomes.
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The First Case of Catheter-related Bloodstream Infection Caused by Kocuria rhizophila in Korea. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-04-21 Yeseul Kim,Taek Soo Kim,Hyunwoong Park,Ki Wook Yun,Jae Hyeon Park
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Real-World Evidence of Point-of-Care Glucometers: Enhanced Passive Surveillance and Adverse Event Reporting Status in Korea and the United States. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-04-21 Sooin Choi,Soo Jeong Choi,Jin Kuk Kim,Yong-Wha Lee,You Kyoung Lee
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The Issue With Osmotic Shock Hemolysate Preparation Procedure. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-04-21 Tejas Kalaria
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RHD*DNT (RHD*38) Showing D-Positive Reactivity on Rhesus D Typing and Forming Anti-D Antibody. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-04-21 Gun-Hyuk Lee,Hanah Kim,Mina Hur,Kyeong A So,Dong Woo Shin,Yun Ji Hong,Kyoung Un Park
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Laboratory Data Quality Evaluation in the Big Data Era. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-04-21 Sollip Kim
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Artificial Intelligence in Point-of-Care Testing. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Adil I Khan, Mazeeya Khan, Raheeb Khan
With the projected increase in the global population, current healthcare delivery models will face severe challenges. Rural and remote areas, whether in developed or developing countries, are characterized by the same challenges: the unavailability of hospitals, lack of trained and skilled staff performing tests, and poor compliance with quality assurance protocols. Point-of-care testing using artificial
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Functional Reference Limits: Describing Physiological Relationships and Determination of Physiological Limits for Enhanced Interpretation of Laboratory Results. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Tyng Yu Chuah, Chun Yee Lim, Rui Zhen Tan, Busadee Pratumvinit, Tze Ping Loh, Samuel Vasikaran, Corey Markus
Functional reference limits describe key changes in the physiological relationship between a pair of physiologically related components. Statistically, this can be represented by a significant change in the curvature of a mathematical function or curve (e.g., an observed plateau). The point at which the statistical relationship changes significantly is the point of curvature inflection and can be mathematically
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Effective and Practical Complete Blood Count Delta Check Method and Criteria for the Quality Control of Automated Hematology Analyzers. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Min-Sun Kim, Chan-Jeoung Park, Seung Namgoong, Seung-Il Kim, Young-Uk Cho, Seongsoo Jang
Delta checks increase patient safety by identifying automated hematology analyzer errors. International standards and guidelines for the complete blood count (CBC) delta check method have not been established. We established an effective, practical CBC delta check method and criteria.
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A New Strategy for Evaluating the Quality of Laboratory Results for Big Data Research: Using External Quality Assessment Survey Data (2010-2020). Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Eun-Jung Cho, Tae-Dong Jeong, Sollip Kim, Hyung-Doo Park, Yeo-Min Yun, Sail Chun, Won-Ki Min
To ensure valid results of big data research in the medical field, the input laboratory results need to be of high quality. We aimed to establish a strategy for evaluating the quality of laboratory results suitable for big data research.
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Comparison of Nasal Swabs, Nasopharyngeal Swabs, and Saliva Samples for the Detection of SARS-CoV-2 and other Respiratory Virus Infections. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Eun Ju Jung, Su Kyung Lee, Seon Hee Shin, Jin Soo Kim, Heungjeong Woo, Eun-Jung Cho, Jungwon Hyun, Jae-Seok Kim, Hyun Soo Kim
Nasal swabs and saliva samples are being considered alternatives to nasopharyngeal swabs (NPSs) for detecting severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2); however, few studies have compared the usefulness of nasal swabs, NPSs, and saliva samples for detecting SARS-CoV-2 and other respiratory virus infections. We compared the positivity rates and concentrations of viruses detected in
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European Committee on Antimicrobial Susceptibility Testing-Recommended Rapid Antimicrobial Susceptibility Testing of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus From Positive Blood Culture Bottles. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Jong-Min Park, Mijung Kwon, Ki Ho Hong, Hyukmin Lee, Dongeun Yong
Early diagnosis and treatment are important for a good prognosis of bloodstream infections. The European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommends rapid antimicrobial susceptibility testing (RAST) based on the disk diffusion methodology for 4, 6, and 8 hours of incubation. We evaluated EUCAST-RAST of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus from
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Effect of Lymphocyte Phenotypic Alterations on the Humoral Response to Vaccination Against SARS-COV-2 in Dialysis Patients. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Georgios Lioulios, Asimina Fylaktou, Despina Asouchidou, Aliki Xochelli, Vasiliki Nikolaidou, Stamatia Stai, Michalis Christodoulou, Panagiotis Giamalis, Ioannis Tsouchnikas, Aikaterini Papagianni, Maria Stangou
The response to vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) varies depending on comorbidities. This study evaluated the clinical and immunological factors affecting the humoral response of patients with end-stage renal disease (ESRD) to the BNT162b2 vaccine.
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Clinical Significance of Serum IgG4 in the Diagnosis and Treatment Response of IgG4-Related Disease in Adults of Southwest China: A Retrospective Study. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Bin Wei, Ying Guo, Xiaoqi Ou, Liyan Lin, Zhenzhen Su, Lixin Li, XiaoJuan Wu, Bei Cai
There is no standard cut-off value of serum IgG4 concentration and serum IgG4/total IgG ratio for the diagnosis of IgG4-related disease (IgG4-RD) or as a marker of treatment responses. We aimed to explore this issue through a retrospective cohort analysis of adults in southwest China.
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Pre-transfusion Testing Using Crossmatching Agglutination Reaction Grades Combined With Rh Subgroup Phenotyping in Patients With Autoantibodies: A Three-year Experience at a Tertiary Hospital. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 Jongmin Kim, Kyung-Hwa Shin, Hyerim Kim, Hyung-Hoi Kim, Hyun-Ji Lee
The currently recommended pre-transfusion testing techniques for patients with autoantibodies are complex, time-consuming, and labor-intensive. Therefore, although the red blood cell (RBC) selection method using crossmatched RBC agglutination reaction grades (i.e., the "least incompatible" transfusion) is discouraged, many institutions still use it. We aimed to evaluate the effectiveness of this method
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Reducing Microbial Contamination in Hematopoietic Stem Cell Products and Quality Improvement Strategy: Retrospective Analysis of 1996-2021 Data. Ann. Lab. Med. (IF 4.9) Pub Date : 2023-4-21 You Keun Ko, Jong Kwon Lee, Hye Kyung Park, Ae Kyung Han, Sun Kyoung Mun, Hye Jeong Park, Hae Kyoung Choung, Se Mi Kim, Kwang Mo Choi, Nam Yong Lee, Duck Cho, Dae Won Kim, Eun-Suk Kang
Sterility and safety assurance of hematopoietic stem cell (HSC) products is critical in transplantation. Microbial contamination can lead to product disposal and increases the risk of unsuccessful clinical outcomes. Therefore, it is important to implement and maintain good practice guidelines and regulations for the HSC collection and processing unit in each hospital. We aimed to share our experiences