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Heart Failure Events in a Clinical Trial on Arterial Hypertension: New Insights Into the SPRINT Trial Hypertension (IF 10.19) Pub Date : 2021-09-13 Piotr Sobieraj, Peter M. Nilsson, Thomas Kahan
SPRINT (Systolic Blood Pressure Intervention Trial) showed that intensive lowering of systolic blood pressure to <120 mm Hg was beneficial, as compared with standard treatment in which systolic blood pressure is lowered to <140 mm Hg. The proposal that the results of SPRINT were mainly driven by the reduction of heart failure events has undermined the main conclusion of the study. Therefore, this study
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Urinary Stress Hormones, Hypertension, and Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis Hypertension (IF 10.19) Pub Date : 2021-09-13 Kosuke Inoue, Tamara Horwich, Roshni Bhatnagar, Karan Bhatt, Deena Goldwater, Teresa Seeman, Karol E. Watson
Psychosocial stress is a key contributing factor to the pathogenesis of hypertension and cardiovascular disease. We examined the association of urinary stress hormone levels with incident hypertension and cardiovascular events. This prospective cohort study included 412 adults (age 48–87 years) free of hypertension from the Multi-Ethnic Study of Atherosclerosis with measurements of urinary stress hormones
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Historical and Recent Changes in Maternal Mortality Due to Hypertensive Disorders in the United States, 1979 to 2018 Hypertension (IF 10.19) Pub Date : 2021-09-13 Cande V. Ananth, Justin S. Brandt, Jennifer Hill, Hillary L. Graham, Sonal Grover, Meike Schuster, Haylea S. Patrick, K.S. Joseph
We evaluated the contributions of maternal age, year of death (period), and year of birth (cohort) on trends in hypertension-related maternal deaths in the United States. We undertook a sequential time series analysis of 155 710 441 live births and 3287 hypertension-related maternal deaths in the United States, 1979 to 2018. Trends in pregnancy-related mortality rate (maternal mortality rate [MMR])
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Evaluation of the Accuracy of Cuffless Blood Pressure Measurement Devices: Challenges and Proposals Hypertension (IF 10.19) Pub Date : 2021-09-13 Ramakrishna Mukkamala, Mohammad Yavarimanesh, Keerthana Natarajan, Jin-Oh Hahn, Konstantinos G. Kyriakoulis, Alberto P. Avolio, George S. Stergiou
Several novel cuffless wearable devices and smartphone applications claiming that they can measure blood pressure (BP) are appearing on the market. These technologies are very attractive and promising, with increasing interest among health care professionals for their potential use. Moreover, they are becoming popular among patients with hypertension and healthy people. However, at the present time
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Clinical Implications Hypertension (IF 10.19) Pub Date : 2021-09-08
Preeclampsia is a complex, life-threatening pregnancy syndrome, both for mother and child, with maternal, placental and fetal characteristics, like hypertension combined with secondary organ failure, placental dysfunction (poor uterine spiral arterial [SpA]-remodeling) and fetal growth restriction associated with increased risk for preterm birth. One biomarker to predict preeclampsia is the antiangiogenic
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Beyond Atherosclerosis and Fibromuscular Dysplasia: Rare Causes of Renovascular Hypertension Hypertension (IF 10.19) Pub Date : 2021-08-30 Alexandre Persu, Caitriona Canning, Aleksander Prejbisz, Piotr Dobrowolski, Laurence Amar, Constantina Chrysochou, Jacek Kądziela, Mieczysław Litwin, Daan van Twist, Patricia Van der Niepen, Gregoire Wuerzner, Peter de Leeuw, Michel Azizi, Magda Januszewicz, Andrzej Januszewicz
Renovascular hypertension is one of the most common forms of secondary hypertension. Over 95% of cases of renovascular hypertension are due either to atherosclerosis of the main renal artery trunks or to fibromuscular dysplasia. These two causes of renal artery stenosis have been extensively discussed in recent reviews and consensus. The aim of the current article is to provide comprehensive and up-to-date
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Redox Switches Controlling Nitric Oxide Signaling in the Resistance Vasculature and Implications for Blood Pressure Regulation: Mid-Career Award for Research Excellence 2020 Hypertension (IF 10.19) Pub Date : 2021-08-23 Atinuke Aramide Modupe Dosunmu-Ogunbi, Joseph C. Galley, Shuai Yuan, Heidi M. Schmidt, Katherine C. Wood, Adam C. Straub
The arterial resistance vasculature modulates blood pressure and flow to match oxygen delivery to tissue metabolic demand. As such, resistance arteries and arterioles have evolved a series of highly orchestrated cell-cell communication mechanisms between endothelial cells and vascular smooth muscle cells to regulate vascular tone. In response to neurohormonal agonists, release of several intracellular
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Long-Term Cardiovascular Disease Risk in Women After Hypertensive Disorders of Pregnancy: Recent Advances in Hypertension Hypertension (IF 10.19) Pub Date : 2021-08-15 Kavia Khosla, Sarah Heimberger, Kristin M. Nieman, Avery Tung, Sajid Shahul, Anne Cathrine Staff, Sarosh Rana
Patients with a history of hypertensive disorders of pregnancy (HDP) suffer higher rates of long-term cardiovascular events including heart failure, coronary artery disease, and stroke. Cardiovascular changes during pregnancy can act as a natural stress test, subsequently unmasking latent cardiovascular disease in the form of HDP. Because HDP now affect 10% of pregnancies in the United States, the
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GSTM1 Gene, Diet, and Kidney Disease: Implication for Precision Medicine?: Recent Advances in Hypertension Hypertension (IF 10.19) Pub Date : 2021-08-30 Thu H. Le
In the United States, the prevalence of chronic kidney disease in adults is ≈14%. The mainstay of therapy for chronic kidney disease is angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, but many patients with chronic kidney disease still progress to end-stage kidney disease. Increased oxidative stress is a major molecular underpinning of chronic kidney disease progression.
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SPRINT—A Kidney-Centric Narrative Review: Recent Advances in Hypertension Hypertension (IF 10.19) Pub Date : 2021-08-09 Austin H. Hu, Tara I. Chang
Hypertension is a potent cardiovascular risk factor with deleterious end-organ effects and is especially prevalent among patients with chronic kidney disease. The SPRINT (Systolic Blood Pressure Intervention Trial) enrolled patients at an elevated cardiac risk including patients with mild to moderate chronic kidney disease and found that an intensive systolic blood pressure goal of <120 mm Hg significantly
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Health Care Delivery Interventions for Hypertension Management in Underserved Populations in the United States: A Systematic Review Hypertension (IF 10.19) Pub Date : 2021-08-15 Maarya Pasha, LaPrincess C. Brewer, Susie Sennhauser, Mouaz Alsawas, M. Hassan Murad
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Effect of a Physician/Pharmacist Collaborative Care Model on Time in Target Range for Systolic Blood Pressure: Post Hoc Analysis of the CAPTION Trial Hypertension (IF 10.19) Pub Date : 2021-08-15 Dave L. Dixon, William L. Baker, Leo F. Buckley, Teresa M. Salgado, Benjamin W. Van Tassell, Barry L. Carter
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Discrepancies in Observed and Predicted Longitudinal Change in Central Hemodynamic Measures: The Framingham Heart Study Hypertension (IF 10.19) Pub Date : 2021-08-09 Leroy L. Cooper, Jian Rong, Martin G. Larson, Emelia J. Benjamin, Naomi M. Hamburg, Ramachandran S. Vasan, Gary F. Mitchell
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SPARTE Study: Normalization of Arterial Stiffness and Cardiovascular Events in Patients With Hypertension at Medium to Very High Risk Hypertension (IF 10.19) Pub Date : 2021-08-30 Stephane Laurent, Gilles Chatellier, Michel Azizi, David Calvet, Gabriel Choukroun, Nicolas Danchin, Pascal Delsart, Xavier Girerd, Philippe Gosse, Hakim Khettab, Gerard London, Jean-Jacques Mourad, Bruno Pannier, Helena Pereira, Dominique Stephan, Paul Valensi, Pedro Cunha, Krzysztof Narkiewicz, Rosa-Maria Bruno, Pierre Boutouyrie, on behalf of SPARTE Investigators
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Long-Term Blood Pressure Variability Increases Risks of Dementia and Cognitive Decline: A Meta-Analysis of Longitudinal Studies Hypertension (IF 10.19) Pub Date : 2021-08-15 Pingping Jia, Helen W.Y. Lee, Joyce Y.C. Chan, Karen K.L. Yiu, Kelvin K.F. Tsoi
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Low THRB (thyroid hormone receptor beta) Promoter Methylation Levels in Peripheral Blood Leukocytes Induced By Systematic Inflammation Are Involved in Low Thyroid Hormone Function in Metabolic Syndrome Hypertension (IF 10.19) Pub Date : 2021-08-15 Bing Cui, Xiao Xiao, Jin’e Wang, Hongrui Wang, Cunjin Wu, Yupeng Yan, Jun Zheng, JingJun Wang, Yuru Zong, Yu Zhang, Rutai Hui, A. Martin Gerdes, Yibo Wang
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Microbial Diversity and Abundance of Parabacteroides Mediate the Associations Between Higher Intake of Flavonoid-Rich Foods and Lower Blood Pressure Hypertension (IF 10.19) Pub Date : 2021-08-23 Amy Jennings, Manja Koch, Corinna Bang, Andre Franke, Wolfgang Lieb, Aedín Cassidy
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Soluble (Pro)Renin Receptor as a Negative Regulator of NCC (Na+-Cl– Cotransporter) Activity Hypertension (IF 10.19) Pub Date : 2021-09-08 Chuanming Xu, Yanting Chen, Fei Wang, Shiying Xie, Tianxin Yang
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Albuminuria Testing in Hypertension and Diabetes: An Individual-Participant Data Meta-Analysis in a Global Consortium Hypertension (IF 10.19) Pub Date : 2021-08-09 Jung-Im Shin, Alex R. Chang, Morgan E. Grams, Josef Coresh, Shoshana H. Ballew, Aditya Surapaneni, Kunihiro Matsushita, Henk J.G. Bilo, Juan J. Carrero, Gabriel Chodick, Kenn B. Daratha, Simerjot K. Jassal, Girish N. Nadkarni, Robert G. Nelson, Christoph Nowak, Nikita Stempniewicz, Keiichi Sumida, Jamie P. Traynor, Mark Woodward, Yingying Sang, Ron T. Gansevoort
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6β-Hydroxytestosterone Promotes Angiotensin II-Induced Hypertension via Enhanced Cytosolic Phospholipase A2α Activity Hypertension (IF 10.19) Pub Date : 2021-08-23 Purnima Singh, Chi Young Song, Shubha R. Dutta, Ajeeth Pingili, Ji Soo Shin, Frank J. Gonzalez, Joseph V. Bonventre, Kafait U. Malik
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Circulating Maternal sFLT1 (Soluble fms-Like Tyrosine Kinase-1) Is Sufficient to Impair Spiral Arterial Remodeling in a Preeclampsia Mouse Model Hypertension (IF 10.19) Pub Date : 2021-08-15 Rebekka Vogtmann, Jacqueline Heupel, Florian Herse, Mahsa Matin, Henning Hagmann, Ivo Bendix, Kristin Kräker, Ralf Dechend, Elke Winterhager, Rainer Kimmig, Angela Köninger, Alexandra Gellhaus
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EPAS1 (Endothelial PAS Domain Protein 1) Orchestrates Transactivation of Endothelial ICAM1 (Intercellular Adhesion Molecule 1) by Small Nucleolar RNA Host Gene 5 (SNHG5) to Promote Hypoxic Pulmonary Hypertension Hypertension (IF 10.19) Pub Date : 2021-08-30 Shouxian Wang, Yu Wang, Chang Liu, Gang Xu, Wenxiang Gao, Jiale Hao, Mengjie Zhang, Gang Wu, Yidong Yang, Jian Huang, Bing Ni, Dewei Chen, Yuqi Gao
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GSK2256294 Decreases sEH (Soluble Epoxide Hydrolase) Activity in Plasma, Muscle, and Adipose and Reduces F2-Isoprostanes but Does Not Alter Insulin Sensitivity in Humans Hypertension (IF 10.19) Pub Date : 2021-08-30 James M. Luther, Justina Ray, Dawei Wei, John R. Koethe, Latoya Hannah, Anthony DeMatteo, Robert Manning, Andrew S. Terker, Dungeng Peng, Hui Nian, Chang Yu, Mona Mashayekhi, Jorge Gamboa, Nancy J. Brown
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Inhibition of HDACs (Histone Deacetylases) Ameliorates High-Fat Diet–Induced Hypertension Through Restoration of the MsrA (Methionine Sulfoxide Reductase A)/Hydrogen Sulfide Axis Hypertension (IF 10.19) Pub Date : 2021-08-15 Jin Ki Jung, Ga-Eun Yoon, GiBong Jang, Kwon Moo Park, InKyeom Kim, Jee In Kim
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Comparative Effectiveness of Gastric Bypass and Vertical Sleeve Gastrectomy for Hypertension Remission and Relapse: The ENGAGE CVD Study Hypertension (IF 10.19) Pub Date : 2021-08-09 Kristi Reynolds, Lee J. Barton, Anirban Basu, Heidi Fischer, David E. Arterburn, Douglas Barthold, Anita Courcoulas, Cecelia L. Crawford, Benjamin B. Kim, Peter N. Fedorka, Edward C. Mun, Sameer B. Murali, Robert E. Zane, Karen J. Coleman
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Sympathetic Neural Mechanisms Underlying Attended and Unattended Blood Pressure Measurement Hypertension (IF 10.19) Pub Date : 2021-08-09 Guido Grassi, Fosca Quarti-Trevano, Gino Seravalle, Raffaella Dell’Oro, Jennifer Vanoli, Gianluca Perseghin, Giuseppe Mancia
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Distinct Regulation of U-ACE2 and P-ACE2 (Urinary and Plasma Angiotensin-Converting Enzyme 2) in a Japanese General Population Hypertension (IF 10.19) Pub Date : 2021-08-23 Masato Furuhashi, Akiko Sakai, Marenao Tanaka, Yukimura Higashiura, Kazuma Mori, Masayuki Koyama, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto
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IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury During Deoxycorticosterone/Salt-Induced Hypertension in Mice Hypertension (IF 10.19) Pub Date : 2021-09-07 Jordyn M. Thomas, Yeong H. Ling, Brooke Huuskes, Maria Jelinic, Prerna Sharma, Narbada Saini, Dorota M. Ferens, Henry Diep, Shalini M. Krishnan, Barbara K. Kemp-Harper, Paul M. O’Connor, Eicke Latz, Thiruma V. Arumugam, Tomasz J. Guzik, Michael J. Hickey, Ashley Mansell, Christopher G. Sobey, Antony Vinh, Grant R. Drummond
IL-18 (interleukin-18) is elevated in hypertensive patients, but its contribution to high blood pressure and end-organ damage is unknown. We examined the role of IL-18 in the development of renal inflammation and injury in a mouse model of low-renin hypertension. Hypertension was induced in male C57BL6/J (WT) and IL-18−/− mice by uninephrectomy, deoxycorticosterone acetate (2.4 mg/d, s.c.) and 0.9%
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Clinical Score and Machine Learning-Based Model to Predict Diagnosis of Primary Aldosteronism in Arterial Hypertension Hypertension (IF 10.19) Pub Date : 2021-09-07 Fabrizio Buffolo, Jacopo Burrello, Alessio Burrello, Daniel Heinrich, Christian Adolf, Lisa Marie Müller, Rusi Chen, Vittorio Forestiero, Elisa Sconfienza, Martina Tetti, Franco Veglio, Tracy Ann Williams, Paolo Mulatero, Silvia Monticone
Primary aldosteronism (PA) is the cause of arterial hypertension in 4% to 6% of patients, and 30% of patients with PA are affected by unilateral and surgically curable forms. Current guidelines recommend screening for PA ≈50% of patients with hypertension on the basis of individual factors, while some experts suggest screening all patients with hypertension. To define the risk of PA and tailor the
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Percutaneous Intracoronary Delivery of Plasma Extracellular Vesicles Protects the Myocardium Against Ischemia-Reperfusion Injury in Canis Hypertension (IF 10.19) Pub Date : 2021-09-07 Hongyun Wang, Rusitanmujiang Maimaitiaili, Jianhua Yao, Yuling Xie, Sujing Qiang, Fan Hu, Xiang Li, Chao Shi, Peng Jia, Haotian Yang, Meng Wei, Juan Zhao, Zheng Zhou, Jinxin Xie, Jizong Jiang, Haidong Cai, Joost P.G. Sluijter, Yawei Xu, Yi Zhang, Junjie Xiao
Plasma circulating extracellular vesicles (EVs) have been utilized as a potential therapeutic strategy to treat ischemic disease through intramyocardial injection (efficient but invasive) or tail vein injection (noninvasive but low cardiac retention). An effective and noninvasive delivery of EVs for future clinical use is necessary. The large animal (canine) model was complemented with a murine ischemia-reperfusion
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Epidemiologic and Genetic Associations of Erythropoietin With Blood Pressure, Hypertension, and Coronary Artery Disease Hypertension (IF 10.19) Pub Date : 2021-09-07 Pengfei Sun, Nitin Kumar, Adrienne Tin, Jing Zhao, Michael R. Brown, Zesen Lin, Min-Lee Yang, Qiwen Zheng, Jia Jia, Lawrence F. Bielak, Bing Yu, Eric Boerwinkle, Kristina L. Hunker, Josef Coresh, Y. Eugene Chen, Yong Huo, Sharon L.R. Kardia, Rami Khoriaty, Xiang Zhou, Alanna C. Morrison, Yan Zhang, Santhi K. Ganesh
While exogenous administration of recombinant erythropoietin has been associated with increased risk of hypertension, coronary artery disease, and mortality, it is not known if endogenous circulating erythropoietin level is associated with coronary artery disease and its risk factors. We measured and analyzed epidemiological and genetic associations of circulating plasma erythropoietin levels in 2
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Transitions in Metabolic Health and Associations With Arterial Stiffness Progression Across Body Mass Index Categories Hypertension (IF 10.19) Pub Date : 2021-09-07 Shouling Wu, Lulu Song, Lulin Wang, Shuohua Chen, Mingyang Wu, Youjie Wang, Yaohua Tian
Metabolically healthy obesity is an unstable state and its transition to a metabolically unhealthy phenotype confers an increased risk of cardiovascular disease. However, it remains unclear whether changes in metabolic health over time are associated with arterial stiffness progression, a key player in the pathophysiology of cardiovascular disease. We aimed to investigate the associations of changes
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Negative Influence of Insufficient Sleep on Endothelial Vasodilator and Fibrinolytic Function in Hypertensive Adults Hypertension (IF 10.19) Pub Date : 2021-09-07 Kelly A. Stockelman, Anthony R. Bain, Anabel Goulding, Noah M. DeSouza, Clay Rahaman, Lukas Maly, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza
Insufficient nightly sleep (<7 hour/night) has been linked to the cause of hypertension and is a prevalent, often ignored, comorbidity. We tested the hypotheses that chronic nightly insufficient sleep is associated with lower nitric oxide-mediated endothelium-dependent vasodilation and endothelial tPA (tissue-type plasminogen activator) release in hypertensive adults; and that the insufficient sleep-related
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Impact of 30- Versus 60-Second Time Intervals Between Automated Office Blood Pressure Measurements on Measured Blood Pressure Hypertension (IF 10.19) Pub Date : 2021-09-07 Stephen P. Juraschek, Anthony M. Ishak, Kenneth J. Mukamal, Julia M. Wood, Timothy S. Anderson, Marc L. Cohen, Jonathan X. Li, Jennifer L. Cluett
Guidelines recommend 1 to 2 minutes between repeated, automated office-based blood pressure (AOBP) measures, which is a barrier to broader adoption. Patients from a single hypertension center underwent a 3-day evaluation that included a 24-hour ambulatory blood pressure (BP) monitor (ABPM) and one of two nonrandomized, unattended AOBP protocols. Half of the patients underwent 3 AOBP measurements separated
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Multicenter Cohort Study, With a Nested Randomized Comparison, to Examine the Cardiovascular Impact of Preterm Preeclampsia Hypertension (IF 10.19) Pub Date : 2021-08-30 Fergus P. McCarthy, Jamie M. O’Driscoll, Paul T. Seed, Anna Placzek, Carolyn Gill, Jenie Sparkes, Lucilla Poston, Mike Marber, Andrew H. Shennan, Basky Thilaganathan, Paul Leeson, Lucy C. Chappell
This study evaluated whether planned early delivery would ameliorate cardiovascular dysfunction 6 months postpartum, compared with usual care with expectant management, in women with late preterm preeclampsia. We conducted a mechanistic observational study in women with preterm preeclampsia between 34+0 and 36+6 weeks’ gestation, nested within a randomized controlled trial of planned early delivery
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Blood Pressure and Left Ventricular Geometric Changes: A Directionality Analysis Hypertension (IF 10.19) Pub Date : 2021-08-30 Miaoying Yun, Shengxu Li, Yinkun Yan, Dianjianyi Sun, Yajun Guo, Camilo Fernandez, Lydia Bazzano, Jiang He, Tao Zhang, Wei Chen
This study assessed the temporal relationship of elevated blood pressure (BP) with left ventricular hypertrophy (LVH) and geometric changes in a longitudinal cohort of adults. Left ventricular mass index (LVMI), relative wall thickness (RWT), and BP were measured at 2 time points 4.1 to 14.9 years apart between 2000 and 2016 among 984 adults (677 White and 307 Black people; 41.1% men; age range, 24
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2021 Distinguished Scientist of the American Heart Association Hypertension (IF 10.19) Pub Date : 2021-08-30
The Distinguished Scientist designation honors American Heart Association professional members who have made extraordinary contributions to cardiovascular and stroke research. The American Heart Association’s Distinguished Scientists are a prominent group of scientists and clinicians whose work has importantly advanced our understanding of cardiovascular diseases and stroke. This award was created
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Association Between Longitudinal Blood Pressure Trajectory and the Progression of Chronic Kidney Disease: Results From the KNOW-CKD Hypertension (IF 10.19) Pub Date : 2021-08-15 Young Su Joo, Hyung Woo Kim, Ki Heon Nam, Jee Young Lee, Tae Ik Chang, Jung Tak Park, Tae-Hyun Yoo, Joongyub Lee, Soo Wan Kim, Yun Kyu Oh, Kook-Hwan Oh, Yong-Soo Kim, Curie Ahn, Shin-Wook Kang, Seung Hyeok Han
Studies on the longitudinal temporal trend of blood pressure (BP) and its impact on kidney function are scarce. Here, we evaluated the association of dynamic changes in systolic blood pressure (SBP) over time with adverse kidney outcomes. We analyzed 1837 participants from the KNOW-CKD (Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease). The main exposure was 3 distinct SBP trajectories
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Clinical Implications Hypertension (IF 10.19) Pub Date : 2021-08-11
Hypertension is a risk factor for cognitive decline and dementia, as well as the most common condition observed in primary care in older adults. Over 70% of adults aged 65 years or older in the United States have blood pressure levels necessitating treatment. Promisingly, previous work has suggested that treating hypertension can stave off not only cognitive decline but also the development of neuropathology
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Nocturnal Hypertension and Heart Failure: Mechanisms, Evidence, and New Treatments Hypertension (IF 10.19) Pub Date : 2021-07-06 Kazuomi Kario, Bryan Williams
Heart failure (HF) is a common condition with an increasing prevalence. Despite a variety of evidence-based treatments for patients with HF with reduced ejection fraction, morbidity and mortality rates remain high. Furthermore, there are currently no treatments that have yet been shown to reduce complication and death rates in patients who have HF with preserved ejection fraction. Hypertension is a
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Hypertension Control in the United States 2009 to 2018: Factors Underlying Falling Control Rates During 2015 to 2018 Across Age- and Race-Ethnicity Groups Hypertension (IF 10.19) Pub Date : 2021-06-14 Brent M. Egan, Jiexiang Li, Susan E. Sutherland, Michael K. Rakotz, Gregory D. Wozniak
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Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers: A Multinational Cohort Study Hypertension (IF 10.19) Pub Date : 2021-07-26 RuiJun Chen, Marc A. Suchard, Harlan M. Krumholz, Martijn J. Schuemie, Steven Shea, Jon Duke, Nicole Pratt, Christian G. Reich, David Madigan, Seng Chan You, Patrick B. Ryan, George Hripcsak
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Selective Inhibition of the C-Domain of ACE (Angiotensin-Converting Enzyme) Combined With Inhibition of NEP (Neprilysin): A Potential New Therapy for Hypertension Hypertension (IF 10.19) Pub Date : 2021-07-26 Rhéure Alves-Lopes, Augusto C. Montezano, Karla B. Neves, Adam Harvey, Francisco J. Rios, Dominik S. Skiba, Lauren B. Arendse, Tomasz J. Guzik, Delyth Graham, Marko Poglitsch, Edward Sturrock, Rhian M. Touyz
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Detection of Nonadherence to Antihypertensive Treatment by Measurements of Serum Drug Concentrations Hypertension (IF 10.19) Pub Date : 2021-07-19 Ola Undrum Bergland, Lene V. Halvorsen, Camilla L. Søraas, Ulla Hjørnholm, Vibeke N. Kjær, Stine Rognstad, Karl Marius Brobak, Arleen Aune, Eirik Olsen, Ylva M. Fauchald, Sondre Heimark, Christian W. Thorstensen, Knut Liestøl, Marit D. Solbu, Eva Gerdts, Rune Mo, Morten Rostrup, Sverre E. Kjeldsen, Aud Høieggen, Mimi S. Opdal, Anne Cecilie K. Larstorp, Fadl Elmula M. Fadl Elmula
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Blood-Brain Barrier Crossing Renin-Angiotensin Drugs and Cognition in the Elderly: A Meta-Analysis Hypertension (IF 10.19) Pub Date : 2021-06-21 Jean K. Ho, Frank Moriarty, Jennifer J. Manly, Eric B. Larson, Denis A. Evans, Kumar B. Rajan, Elizabeth M. Hudak, Lamiaa Hassan, Enwu Liu, Nobuyuki Sato, Naoyuki Hasebe, Danielle Laurin, Pierre-Hugues Carmichael, Daniel A. Nation
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Piezo1-Mediated Mechanotransduction Promotes Cardiac Hypertrophy by Impairing Calcium Homeostasis to Activate Calpain/Calcineurin Signaling Hypertension (IF 10.19) Pub Date : 2021-08-02 Yuhao Zhang, Sheng-an Su, Wudi Li, Yuankun Ma, Jian Shen, Yaping Wang, Yimin Shen, Jian Chen, Yongli Ji, Yao Xie, Hong Ma, Meixiang Xiang
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Left Atrioventricular Coupling Index as a Prognostic Marker of Cardiovascular Events: The MESA Study Hypertension (IF 10.19) Pub Date : 2021-07-06 Theo Pezel, Bharath Ambale Venkatesh, Henrique Doria De Vasconcellos, Yoko Kato, Mahsima Shabani, Eric Xie, Susan R. Heckbert, Wendy S. Post, Steven J. Shea, Norrina B. Allen, Karol E. Watson, Colin O. Wu, David A. Bluemke, João A.C. Lima
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Persistent Hypertension and Left Ventricular Hypertrophy After Repair of Native Coarctation of Aorta in Adults Hypertension (IF 10.19) Pub Date : 2021-07-12 Alexander C. Egbe, William R. Miranda, Carole A Warnes, Crystal Bonnichsen, Juan Crestanello, Jason H. Anderson, Heidi M. Connolly
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Targeting Tyrosine Hydroxylase for Abdominal Aortic Aneurysm: Impact on Inflammation, Oxidative Stress, and Vascular Remodeling Hypertension (IF 10.19) Pub Date : 2021-07-26 Laia Cañes, Judith Alonso, Carme Ballester-Servera, Saray Varona, José R. Escudero, Vicente Andrés, Cristina Rodríguez, José Martínez-González
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Long Noncoding RNA Tug1 Promotes Angiotensin II–Induced Renal Fibrosis by Binding to Mineralocorticoid Receptor and Negatively Regulating MicroR-29b-3p Hypertension (IF 10.19) Pub Date : 2021-08-02 Juhong Zhang, Yuqing Zhang, Jing Gao, Meihui Wang, Xiaoting Li, Zhaoqiang Cui, Guosheng Fu
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Renal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure Hypertension (IF 10.19) Pub Date : 2021-08-02 Lindsea C. Booth, R. Anethra U. de Silva, Roberto B. Pontes, Song T. Yao, Sally G. Hood, Yugeesh R. Lankadeva, Junko Kosaka, Nina Eikelis, Gavin W. Lambert, Markus P. Schlaich, Clive N. May
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Associations of Insulin Resistance With Systolic and Diastolic Blood Pressure: A Study From the HCHS/SOL Hypertension (IF 10.19) Pub Date : 2021-08-11 Odayme Quesada, Brian Claggett, Fatima Rodriguez, Jianwen Cai, Ashley E. Moncrieft, Karin Garcia, Marina Del Rios Rivera, David B. Hanna, Martha L. Daviglus, Gregory A. Talavera, C. Noel Bairey Merz, Scott D. Solomon, Susan Cheng, Natalie A. Bello
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Characterization of Circulating Extracellular Vesicle Surface Antigens in Patients With Primary Aldosteronism Hypertension (IF 10.19) Pub Date : 2021-07-26 Jacopo Burrello, Martina Tetti, Vittorio Forestiero, Vanessa Biemmi, Sara Bolis, Margherita Alba Carlotta Pomatto, Martina Amongero, Dario Di Silvestre, Pierluigi Mauri, Giuseppe Vassalli, Giovanni Camussi, Tracy Ann Williams, Paolo Mulatero, Lucio Barile, Silvia Monticone
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Aldosterone Synthase Structure With Cushing Disease Drug LCI699 Highlights Avenues for Selective CYP11B Drug Design Hypertension (IF 10.19) Pub Date : 2021-07-12 Simone Brixius-Anderko, Emily E. Scott
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Differentiating Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome and Atypical Hemolytic Uremic Syndrome in the Postpartum Period Hypertension (IF 10.19) Pub Date : 2021-07-19 Richard M. Burwick, Kimberly Moyle, Anuja Java, Megha Gupta
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From Normal Cognition to Cognitive Impairment and Dementia: Impact of Orthostatic Hypotension Hypertension (IF 10.19) Pub Date : 2021-07-06 Xin Xia, Rui Wang, Davide L. Vetrano, Giulia Grande, Erika J. Laukka, Mozhu Ding, Laura Fratiglioni, Chengxuan Qiu
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Estimation of the Global Gap in Clinic Visits for Hypertension Care Between Patient Need and Physician Capacity Hypertension (IF 10.19) Pub Date : 2021-08-11 Dinesh Neupane, Yumin Gao, Yijing Feng, Kunihiro Matsushita, Lawrence J. Appel
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Influence of Maternal Lifestyle and Diet on Perinatal DNA Methylation Signatures Associated With Childhood Arterial Stiffness at 8 to 9 Years Hypertension (IF 10.19) Pub Date : 2021-07-19 Robert Murray, Negusse Kitaba, Elie Antoun, Philip Titcombe, Sheila Barton, Cyrus Cooper, Hazel M. Inskip, Graham C. Burdge, Pamela A. Mahon, John Deanfield, Julian P. Halcox, Elizabeth A. Ellins, Jennifer Bryant, Charles Peebles, Karen Lillycrop, Keith M. Godfrey, Mark A. Hanson, EpiGen Consortium
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Essential Hypertension Is Associated With Changes in Gut Microbial Metabolic Pathways: A Multisite Analysis of Ambulatory Blood Pressure Hypertension (IF 10.19) Pub Date : 2021-08-02 Michael Nakai, Rosilene V. Ribeiro, Bruce R. Stevens, Paul Gill, Rikeish R. Muralitharan, Stephanie Yiallourou, Jane Muir, Melinda Carrington, Geoffrey A. Head, David M. Kaye, Francine Z. Marques
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Novel Role of GPR35 (G-Protein–Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure Hypertension (IF 10.19) Pub Date : 2021-07-19 Hainan Li, Huong Nguyen, Sai Pranathi Meda Venkata, Jia Yi Koh, Anjaneyulu Kowluru, Li Li, Noreen F. Rossi, Wei Chen, Jie-Mei Wang
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