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Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population Hypertension (IF 8.3) Pub Date : 2024-03-18 Hayat Aljaibeji, Mahyar Heydarpour, Ana Maria Stanton, Jonathan S. Williams, Luminita H. Pojoga, Jose R. Romero, Gordon H. Williams
BACKGROUND:The mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex 1) when it binds with RAPTOR (Regulatory-associated Protein of mTOR) and mTORC2 (mTOR complex 2) when it associates with RICTOR (Rapamycin-insesitive companion of mTOR). Due to the previous link between the mTOR pathway, aldosterone
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Identification of Circulating Plasma Proteins as a Mediator of Hypertension-Driven Cardiac Remodeling: A Mediation Mendelian Randomization Study Hypertension (IF 8.3) Pub Date : 2024-03-15 Yuanlong Hu, Lin Lin, Lei Zhang, Yuan Li, Xinhai Cui, Mengkai Lu, Zhiyuan Zhang, Xiuya Guan, Muxin Zhang, Jiaqi Hao, Xiaojie Wang, Jiaming Huan, Wenqing Yang, Chao Li, Yunlun Li
BACKGROUND:This study focused on circulating plasma protein profiles to identify mediators of hypertension-driven myocardial remodeling and heart failure.METHODS:A Mendelian randomization design was used to investigate the causal impact of systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure on 82 cardiac magnetic resonance traits and heart failure risk. Mediation analyses
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Cytokines, C-Reactive Protein, and Risk of Incident Hypertension in the REGARDS Study Hypertension (IF 8.3) Pub Date : 2024-03-15 Timothy B. Plante, Stephen P. Juraschek, George Howard, Virginia J. Howard, Russell P. Tracy, Nels C. Olson, Suzanne E. Judd, Debora Kamin Mukaz, Neil A. Zakai, D. Leann Long, Mary Cushman
BACKGROUND:Hypertension is a highly prevalent cardiovascular disease risk factor that may be related to inflammation. Whether adverse levels of specific inflammatory cytokines relate to hypertension is unknown. The present study sought to determine whether higher levels of IL (interleukin)-1β, IL-6, TNF (tumor necrosis factor)-α, IFN (interferon)-γ, IL-17A, and CRP (C-reactive protein) are associated
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Association of Blood Pressure With Brain White Matter Microstructural Integrity Assessed With MRI Diffusion Tensor Imaging in Healthy Young Adults Hypertension (IF 8.3) Pub Date : 2024-03-15 Junyeon Won, Pauline Maillard, Kevin Shan, John Ashely, Danilo Cardim, David C. Zhu, Rong Zhang
BACKGROUND:High blood pressure (BP) in middle-aged and older adults is associated with a brain white matter (WM) microstructural abnormality. However, little evidence is available in healthy young adults. We investigated the associations between high BP and WM microstructural integrity in young adults.METHODS:This study included 1015 healthy young adults (542 female, 22–37 years) from the Human Connectome
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Therapeutic Inertia With Initial Low-Dose Quadruple Combination Therapy for Hypertension: Results From the QUARTET Trial Hypertension (IF 8.3) Pub Date : 2024-03-13 Nelson Wang, Amy von Huben, Simone Marschner, Mark Nelson, Janis M. Nolde, Markus Schlaich, Gemma Figtree, Graham Hillis, Tim Usherwood, Christopher Reid, John Chalmers, Shirley Jansen, Emily R. Atkins, Laurent Billot, Clara Chow, Anthony Rodgers, On behalf of the QUARTET Investigators
BACKGROUND:Low-dose combinations are a promising intervention for improving blood pressure (BP) control but their effects on therapeutic inertia are uncertain.METHODS:Analysis of 591 patients randomized to an ultra-low-dose quadruple pill or initial monotherapy. The episode of therapeutic inertia was defined as a patient visit with a BP of >140/90 mm Hg without intensification of antihypertensive treatment
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Rationale of the Inclusion of β-Blockers Among Major Antihypertensive Drugs in the 2023 European Society of Hypertension Guidelines Hypertension (IF 8.3) Pub Date : 2024-03-13 Giuseppe Mancia, Mattias Brunström, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Sverre E. Kjeldsen, Maria L. Muiesan, Costas Thomopoulos, Konstantinos Tsioufis, Reinhold Kreutz
We address the reasons why, unlike other guidelines, in the 2023 guidelines of the European Society of Hypertension β-blockers (BBs) have been regarded as major drugs for the treatment of hypertension, at the same level as diuretics, calcium channel blockers, and blockers of the renin-angiotensin system. We argue that BBs, (1) reduce blood pressure (the main factor responsible for treatment-related
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Association of Blood Pressure With Brain Ages: A Cohort Study of Gray and White Matter Aging Discrepancy in Mid-to-Older Adults From UK Biobank Hypertension (IF 8.3) Pub Date : 2024-03-11 Jing Du, Yuangang Pan, Jiyang Jiang, Yue Liu, Ben C.P. Lam, Aletta E. Schutte, Ivor W. Tsang, Perminder S. Sachdev, Wei Wen
BACKGROUND:Gray matter (GM) and white matter (WM) impairments are both associated with raised blood pressure (BP), although whether elevated BP is differentially associated with the GM and WM aging process remains inadequately examined.METHODS:We included 37 327 participants with diffusion-weighted imaging (DWI) and 39 630 participants with T1-weighted scans from UK Biobank. BP was classified into
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Associations of Proteomics With Hypertension and Systolic Blood Pressure: KORA S4/F4/FF4 and KORA-Age1/Age2 Cohort Studies Hypertension (IF 8.3) Pub Date : 2024-03-06 Jie-sheng Lin, Agnese Petrera, Stefanie M. Hauck, Christian L. Müller, Annette Peters, Barbara Thorand
BACKGROUND:Hypertension, a complex condition, is primarily defined based on blood pressure readings without involving its pathophysiological mechanisms. We aimed to identify biomarkers through a proteomic approach, thereby enhancing the future definition of hypertension with insights into its molecular mechanisms.METHODS:The discovery analysis included 1560 participants, aged 55 to 74 years at baseline
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Ovariectomy-Induced Arterial Stiffening Differs From Vascular Aging and Is Reversed by GPER Activation Hypertension (IF 8.3) Pub Date : 2024-03-06 Isabella M. Kilanowski-Doroh, Alexandra B. McNally, Tristen Wong, Bruna Visniauskas, Sophia A. Blessinger, Ariane Imulinde Sugi, Chase Richard, Zaidmara Diaz, Alec Horton, Christopher A. Natale, Benard O. Ogola, Sarah H. Lindsey
BACKGROUND:Arterial stiffness is a cardiovascular risk factor and dramatically increases as women transition through menopause. The current study assessed whether a mouse model of menopause increases arterial stiffness in a similar manner to aging and whether activation of the G-protein–coupled estrogen receptor could reverse stiffness.METHODS:Female C57Bl/6J mice were ovariectomized at 10 weeks of
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Hypertension, Neurodegeneration, and Cognitive Decline Hypertension (IF 8.3) Pub Date : 2024-03-01 Anthony Pacholko, Costantino Iadecola
Elevated blood pressure is a well-established risk factor for age-related cognitive decline. Long linked to cognitive impairment on vascular bases, increasing evidence suggests a potential association of hypertension with the neurodegenerative pathology underlying Alzheimer disease. Hypertension is well known to disrupt the structural and functional integrity of the cerebral vasculature. However, the
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Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond Hypertension (IF 8.3) Pub Date : 2024-03-01 Nicholas D. Camarda, Jaime Ibarrola, Lauren A. Biwer, Iris Z. Jaffe
After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR) in the vasculature, the advent of technology to specifically knockout the MR from smooth muscle cells (SMCs) in mice has elucidated contributions of SMC-MR to cardiovascular function and disease, independent of the kidney. This review summarizes the latest understanding of the molecular mechanisms by which
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Mortality and Cardiovascular End Points In Relation to the Aortic Pulse Wave Components: An Individual-Participant Meta-Analysis Hypertension (IF 8.3) Pub Date : 2024-02-23 Gavin R. Norton, De-Wei An, Lucas S. Aparicio, Yu-Ling Yu, Fang-Fei Wei, Teemu J. Niiranen, Chen Liu, Katarzyna Stolarz-Skrzypek, Wiktoria Wojciechowska, Antti M. Jula, Marek Rajzer, Dries S. Martens, Peter Verhamme, Yan Li, Kalina Kawecka-Jaszcz, Tim S. Nawrot, Jan A. Staessen, Angela J. Woodiwiss, The International Database of Central Arterial Properties for Risk Stratification Investigators‡
BACKGROUND:Wave separation analysis enables individualized evaluation of the aortic pulse wave components. Previous studies focused on the pressure height with overall positive but differing results. In the present analysis, we assessed the associations of the pressure of forward and backward (Pfor and Pref) pulse waves with prospective cardiovascular end points, with extended analysis for time to
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Trends in All-Cause, Cardiovascular, and Noncardiovascular Mortality Among US Adults With Hypertension Hypertension (IF 8.3) Pub Date : 2024-02-23 Eunhee Choi, Daichi Shimbo, Ligong Chen, Kathryn Foti, Lama Ghazi, Shakia T. Hardy, Paul Muntner
Background:Death certificate data indicate that hypertension may have increased as a contributing cause of death among US adults. Hypertension is not commonly recorded on death certificates although it contributes to a substantial proportion of cardiovascular disease (CVD) deaths.Methods:We estimated changes in all-cause, CVD, and non-CVD mortality over 5 years of follow-up among 4 cohorts of US adults
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Sodium, Interstitium, Lymphatics, and Hypertension—A Tale of Hydraulics: Salt Series Hypertension (IF 8.3) Pub Date : 2024-02-22 Giacomo Rossitto, Giovanni Bertoldi, Joseph M. Rutkowski, Brett M. Mitchell, Christian Delles
Blood pressure is regulated by vascular resistance and intravascular volume. However, exchanges of electrolytes and water between intra and extracellular spaces and filtration of fluid and solutes in the capillary beds blur the separation between intravascular and interstitial compartments. Contemporary paradigms of microvascular exchange posit filtration of fluids and solutes along the whole capillary
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Overview of the Evolution of Hypertension: From Ancient Chinese Emperors to Today Hypertension (IF 8.3) Pub Date : 2024-02-22 George L. Bakris, Michael A. Weber
Hypertension is one of the most commonly treated conditions in modern medical practice, but despite its long history, it was largely ignored until the midpoint of the 20th century. This article will review the origins of elevated blood pressure from when it was first appreciated in 2600 BC to its most recent emerging treatments. Awareness of sustained elevations in blood pressure goes back to the Chinese
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Sympathetic Neural Control at Rest and During the Cold Pressor Test in Patients With Heart Failure With Preserved Ejection Fraction Hypertension (IF 8.3) Pub Date : 2024-02-22 Ryosuke Takeda, Sarah L. Hissen, John D. Akins, Takuro Washio, Christopher M. Hearon Jr, James P. MacNamara, Satyam Sarma, Benjamin D. Levine, Paul J. Fadel, Qi Fu
Background:We tested the hypothesis that patients with heart failure with preserved ejection fraction (HFpEF) would have greater muscle sympathetic nerve activity (MSNA) at rest and sympathetic reactivity during a cold pressor test compared with non–heart failure controls. Further, given the importance of the baroreflex modulation of MSNA in the control of blood pressure (BP), we hypothesized that
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Incident Cardiovascular Disease in Women With Type 1 or Type 2 Diabetes Following a Hypertensive Disorder of Pregnancy Hypertension (IF 8.3) Pub Date : 2024-02-22 Kristina Mattsson, Mats Pihlsgård, Sofia Enhörning, Simon Timpka
BACKGROUND:The extent to which a history of hypertensive disorders of pregnancy is associated with incident cardiovascular disease also among women with diabetes is unknown.METHODS:In this nationwide register-based cohort study, parous women aged 18 to 69 years with a first delivery in the Swedish Medical Birth Register, regardless of diabetic status at that time, and a subsequent clinical visit in
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Forgotten Circulation: Reduced Mesenteric Venous Capacitance in Hypertensive Rats Is Improved by Decreasing Sympathetic Activity Hypertension (IF 8.3) Pub Date : 2024-02-21 Tonja W. Emans, Davi J.A. Moraes, Alona Ben-Tal, Carolyn J. Barrett, Julian F.R. Paton, Fiona D. McBryde
BACKGROUND:The mesenteric venous reservoir plays a vital role in mediating blood volume and pressure changes and is richly innervated by sympathetic nerves; however, the precise nature of venous sympathetic regulation and its role during hypertension remains unclear. We hypothesized that sympathetic drive to mesenteric veins in spontaneously hypertensive (SH) rats is raised, increasing mean circulatory
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AI, Machine Learning, and ChatGPT in Hypertension Hypertension (IF 8.3) Pub Date : 2024-02-21 Anita T. Layton
Hypertension, a leading cause of cardiovascular disease and premature death, remains incompletely understood despite extensive research. Indeed, even though numerous drugs are available, achieving adequate blood pressure control remains a challenge, prompting recent interest in artificial intelligence. To promote the use of machine learning in cardiovascular medicine, this review provides a brief introduction
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Milestone Papers in Signal Transduction Mechanisms of Hypertension and Its Complications Hypertension (IF 8.3) Pub Date : 2024-02-19 Satoru Eguchi, Keiichi Torimoto, Adebowale Adebiyi, Praghalathan Kanthakumar, Gisele F. Bomfim, Camilla Ferreira Wenceslau, Shelby A. Dahlen, Patrick Osei-Owusu
To celebrate 100 years of AHA-supported cardiovascular disease research, this review article highlights milestone papers that have significantly contributed to the current understanding of the signaling mechanisms driving hypertension and associated cardiovascular disorders. This article also includes a few of the future research directions arising from these critical findings. To accomplish this important
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Alternative Renin-Angiotensin System Hypertension (IF 8.3) Pub Date : 2024-02-16 Michael Bader, U. Muscha Steckelings, Natalia Alenina, Robson A.S. Santos, Carlos M. Ferrario
The renin-angiotensin system is the most important peptide hormone system in the regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin, and angiotensin-converting enzyme, generating angiotensin II from angiotensinogen, which activates its AT1 receptor, thereby increasing blood pressure, retaining salt and water, and inducing cardiovascular hypertrophy and fibrosis
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Differential 5′-tRNA Fragment Expression in Circulating Preeclampsia Syncytiotrophoblast Vesicles Drives Macrophage Inflammation Hypertension (IF 8.3) Pub Date : 2024-02-16 William Robert Cooke, Peiyong Jiang, Lu Ji, Jinyue Bai, Gabriel Davis Jones, Y. M. Dennis Lo, Christopher Redman, Manu Vatish
BACKGROUND:The relationship between placental pathology and the maternal syndrome of preeclampsia is incompletely characterized. Mismatch between placental nutrient supply and fetal demands induces stress in the syncytiotrophoblast, the layer of placenta in direct contact with maternal blood. Such stress alters the content and increases the release of syncytiotrophoblast extracellular vesicles (STB-EVs)
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T- and L-Type Calcium Channels Maintain Calcium Oscillations in the Murine Zona Glomerulosa Hypertension (IF 8.3) Pub Date : 2024-02-16 Hoang An Dinh, Marina Volkert, Ali Kerim Secener, Ute I. Scholl, Gabriel Stölting
BACKGROUND:The zona glomerulosa of the adrenal gland is responsible for the synthesis and release of the mineralocorticoid aldosterone. This steroid hormone regulates salt reabsorption in the kidney and blood pressure. The most important stimuli of aldosterone synthesis are the serum concentrations of angiotensin II and potassium. In response to these stimuli, voltage and intracellular calcium levels
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Statins Prevent the Deleterious Consequences of Placental Chemerin Upregulation in Preeclampsia Hypertension (IF 8.3) Pub Date : 2024-02-15 Lunbo Tan, Ans C.M. Kluivers, Edwyn O. Cruz-López, Michelle Broekhuizen, Zhongli Chen, Rugina I. Neuman, Sam Schoenmakers, Liesbeth Ruijgrok, Daan van de Velde, Brenda C.M. de Winter, Antoon J. van den Bogaerdt, Xifeng Lu, A.H. Jan Danser, Koen Verdonk
BACKGROUND:Chemerin, an inflammatory adipokine, is upregulated in preeclampsia, and its placental overexpression results in preeclampsia-like symptoms in mice. Statins may lower chemerin.METHODS:Chemerin was determined in a prospective cohort study in women suspected of preeclampsia and evaluated as a predictor versus the sFlt-1 (soluble fms-like tyrosine kinase-1)/PlGF (placental growth factor) ratio
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Circulating Dipeptidyl Peptidase 3 Modulates Systemic and Renal Hemodynamics Through Cleavage of Angiotensin Peptides Hypertension (IF 8.3) Pub Date : 2024-02-09 Adrien Picod, Sandrine Placier, Magali Genest, Jacques Callebert, Nathan Julian, Maxime Zalc, Noma Assad, Hugo Nordin, Karine Santos, Stéphane Gaudry, Christos Chatziantoniou, Alexandre Mebazaa, Feriel Azibani
BACKGROUND:High circulating DPP3 (dipeptidyl peptidase 3) has been associated with poor prognosis in critically ill patients with circulatory failure. In such situation, DPP3 could play a pathological role, putatively via an excessive angiotensin peptides cleavage. Our objective was to investigate the hemodynamics changes induced by DPP3 in mice and the relation between the observed effects and renin–angiotensin
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Maternal Smoking and Risk of Hypertensive Disorders of Pregnancy: Effect Modification by Body Mass Index and Gestational Weight Gain Hypertension (IF 8.3) Pub Date : 2024-02-08 Morgan C. Dunn, Cande V. Ananth, Todd Rosen
BACKGROUND:Although smoking cigarettes has been shown to have a protective effect on preeclampsia, quitting smoking also results in weight gain. Weight gain leading to an obese body mass index is a risk factor for hypertensive disorders of pregnancy (HDP).METHODS:The objective of this study was to explore the relationship between smoking status, body mass index, and gestational weight gain on the risk
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Unilateral Primary Aldosteronism: Long-Term Disease Recurrence After Adrenalectomy Hypertension (IF 8.3) Pub Date : 2024-02-06 Martina Tetti, Denise Brüdgam, Jacopo Burrello, Aaron M. Udager, Anna Riester, Thomas Knösel, Felix Beuschlein, William E. Rainey, Martin Reincke, Tracy Ann Williams
BACKGROUND:Primary aldosteronism (PA) is frequently caused by a unilateral aldosterone-producing adenoma with a PA-driver mutation. Unilateral adrenalectomy has a high probability of short-term biochemical remission, but long-term postsurgical outcomes are relatively undefined. Our objective was to investigate the incidence of long-term recurrence of PA in individuals with postsurgical short-term biochemical
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Impact of Antihypertensive Medication Changes After Renal Denervation Among Different Patient Groups: SPYRAL HTN-ON MED Hypertension (IF 8.3) Pub Date : 2024-02-05 Raymond R. Townsend, Keith C. Ferdinand, David E. Kandzari, Kazuomi Kario, Felix Mahfoud, Michael A. Weber, Roland E. Schmieder, Stuart Pocock, Konstantinos Tsioufis, Shukri David, Susan Steigerwalt, Antony Walton, Ingrid Hopper, Barry Bertolet, Faisal Sharif, Karl Fengler, Martin Fahy, Douglas A. Hettrick, Sandeep Brar, Michael Böhm
BACKGROUND:The SPYRAL HTN-ON MED trial showed significant office and nighttime systolic blood pressure (BP) reductions in patients with hypertension following renal denervation (RDN) compared with sham-control patients, despite similar 24-hour BP reductions. We compared antihypertensive medication and BP changes among prespecified subpopulations.METHODS:The multicenter, randomized, sham-controlled
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Preeclampsia Associated Differences in the Placenta, Fetal Brain, and Maternal Heart Can Be Demonstrated Antenatally: An Observational Cohort Study Using MRI Hypertension (IF 8.3) Pub Date : 2024-02-05 Megan Hall, Antonio de Marvao, Ronny Schweitzer, Daniel Cromb, Kathleen Colford, Priya Jandu, Declan P O’Regan, Alison Ho, Anthony Price, Lucy C. Chappell, Mary A. Rutherford, Lisa Story, Pablo Lamata, Jana Hutter
BACKGROUND:Preeclampsia is a multiorgan disease of pregnancy that has short- and long-term implications for the woman and fetus, whose immediate impact is poorly understood. We present a novel multiorgan approach to magnetic resonance imaging (MRI) investigation of preeclampsia, with the acquisition of maternal cardiac, placental, and fetal brain anatomic and functional imaging.METHODS:An observational
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Potassium-Enriched Salt Substitutes: A Review of Recommendations in Clinical Management Guidelines Hypertension (IF 8.3) Pub Date : 2024-01-29 Xiaoyue Xu, Ling Zeng, Vivekanand Jha, Laura K. Cobb, Kenji Shibuya, Lawrence J. Appel, Bruce Neal, Aletta E. Schutte
Excess dietary sodium intake and insufficient dietary potassium intake are both well-established risk factors for hypertension. Despite some successful initiatives, efforts to control hypertension by improving dietary intake have largely failed because the changes required are mostly too hard to implement. Consistent recent data from randomized controlled trials show that potassium-enriched, sodium-reduced
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Preconception Blood Pressure and Adverse Pregnancy Outcomes: A Population-Based Cohort Study Hypertension (IF 8.3) Pub Date : 2024-01-24 Wenxue Xiong, Lu Han, Xijia Tang, Qiong Wang, Wen Chen, Rui Li, Hui Zhang, Xiaohua Liu, Hua Nie, Weibing Qin, Yang Hu, Zhirong Zhang, Li Ling
BACKGROUND:Adverse pregnancy outcomes (APOs) share clinical features and risk factors with cardiovascular disease and there is an increasing prevalence of hypertension among reproductive women. However, the associations between maternal preconception blood pressure (BP) and APOs remain controversial and inconclusive.METHODS:This population-based cohort study used data of 567 127 mother-neonate-father
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Detection and Control of Pregnancy Hypertension Using Self-Monitoring of Blood Pressure With Automated Telemonitoring: Cost Analyses of the BUMP Randomized Trials Hypertension (IF 8.3) Pub Date : 2024-01-23 Helen E. Campbell, Lucy C. Chappell, Richard J. McManus, Katherine L. Tucker, Carole Crawford, Marcus Green, Oliver Rivero-Arias
BACKGROUND:Pregnancy hypertension continues to cause maternal and perinatal morbidity. Two linked UK randomized trials showed adding self-monitoring of blood pressure (SMBP) with automated telemonitoring to usual antenatal care did not result in earlier detection or better control of pregnancy hypertension. This article reports the trials’ integrated cost analyses.METHODS:Two cost analyses. SMBP with
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Kinase Scaffold Cab39 Is Necessary for Phospho-Activation of the Thiazide-Sensitive NCC Hypertension (IF 8.3) Pub Date : 2024-01-23 Mohammed Z. Ferdaus, Rainelli Koumangoye, Paul A. Welling, Eric Delpire
BACKGROUND:Potassium regulates the WNK (with no lysine kinase)-SPAK (STE20/SPS1-related proline/alanine-rich kinase) signaling axis, which in turn controls the phosphorylation and activation of the distal convoluted tubule thiazide-sensitive NCC (sodium-chloride cotransporter) for sodium-potassium balance. Although their roles in the kidney have not been investigated, it has been postulated that Cab39
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Role of the CCL5 and Its Receptor, CCR5 in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage Hypertension (IF 8.3) Pub Date : 2024-01-19 Rafael M. Costa, Débora M. Cerqueira, Ariane Bruder-Nascimento, Juliano V. Alves, Wanessa M.C. Awata, Shubhnita Singh, Alexander Kufner, Douglas S. Prado, Ebin Johny, Eugenia Cifuentes-Pagano, William F. Hawse, Partha Dutta, Patrick J. Pagano, Jacqueline Ho, Thiago Bruder-Nascimento
BACKGROUND:Aldosterone has been described to initiate cardiovascular diseases by triggering exacerbated sterile vascular inflammation. The functions of CCL5 (C-C motif chemokine ligand 5) and its receptor CCR5 (C-C motif chemokine receptor 5) are well known in infectious diseases, their contributions to aldosterone-induced vascular injury and hypertension remain unknown.METHODS:We analyzed the vascular
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Atlas of Cell Repertoire Within Neointimal Lesions Is Metabolically Altered in Hypertensive Rats Hypertension (IF 8.3) Pub Date : 2024-01-19 Xiaolei Sun, Junru Wu, Xiaolin Zhang, Cheng Xie, Haijun Wei, Pengyun Li, Yan Yang, Hong Yuan, Jingjing Cai, Qingzhong Xiao, Jun Cheng, Qingbo Xu
BACKGROUND:High blood pressure has been suggested to accelerate vascular injury-induced neointimal formation and progression. However, little is known about the intricate relationships between vascular injury and hypertension in the context of arterial remodeling.METHODS:Single-cell RNA-sequencing analysis was used to depict the cell atlas of carotid arteries of Wistar Kyoto rats and spontaneously
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Asymmetric Dimethylarginine Enables Depolarizing Spikes and Vasospasm in Mesenteric and Coronary Resistance Arteries Hypertension (IF 8.3) Pub Date : 2024-01-16 Yu Y. Hanson Ng, Kim A. Dora, Hamish A.L. Lemmey, JinHeng Lin, James Alden, Lillian Wallis, Lucy Donovan, Oliver Shorthose, Fiona C. Leiper, James Leiper, Christopher J. Garland
BACKGROUND:Increased vasoreactivity due to reduced endothelial NO bioavailability is an underlying feature of cardiovascular disease, including hypertension. In small resistance arteries, declining NO enhances vascular smooth muscle (VSM) reactivity partly by enabling rapid depolarizing Ca2+-based spikes that underlie vasospasm. The endogenous NO synthase inhibitor asymmetrical dimethylarginine (ADMA)
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Genome-Wide Interaction Analysis With DASH Diet Score Identified Novel Loci for Systolic Blood Pressure Hypertension (IF 8.3) Pub Date : 2024-01-16 Mélanie Guirette, Jessie Lan, Nicola M. McKeown, Michael R. Brown, Han Chen, Paul S. de Vries, Hyunju Kim, Casey M. Rebholz, Alanna C. Morrison, Traci M. Bartz, Amanda M. Fretts, Xiuqing Guo, Rozenn N. Lemaitre, Ching-Ti Liu, Raymond Noordam, Renée de Mutsert, Frits R. Rosendaal, Carol A. Wang, Lawrence J. Beilin, Trevor A. Mori, Wendy H. Oddy, Craig E. Pennell, Jin Fang Chai, Clare Whitton, Rob M
BACKGROUND:The Dietary Approaches to Stop Hypertension (DASH) diet score lowers blood pressure (BP). We examined interactions between genotype and the DASH diet score in relation to systolic BP.METHODS:We analyzed up to 9 420 585 single nucleotide polymorphisms in up to 127 282 individuals of 6 population groups (91% of European population) from the Cohorts for Heart and Aging Research in Genomic Epidemiology
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Orthostatic Hypotension in Adults With Hypertension: A Scientific Statement From the American Heart Association Hypertension (IF 8.3) Pub Date : 2024-01-11 Stephen P. Juraschek, Melissa M. Cortez, John M. Flack, Lama Ghazi, Rose Anne Kenny, Mahboob Rahman, Telisa Spikes, Cyndya A. Shibao, Italo Biaggioni, on behalf of the American Heart Association Council on Hypertension
Although orthostatic hypotension (OH) has long been recognized as a manifestation of autonomic dysfunction, a growing body of literature has identified OH as a common comorbidity of hypertension. This connection is complex, related to pathophysiology in blood pressure regulation and the manner by which OH is derived as the difference between 2 blood pressure measurements. While traditional therapeutic
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Pulmonary Hypertension Induces Serotonin Hyperreactivity and Metabolic Reprogramming in Coronary Arteries via NOX1/4-TRPM2 Signaling Pathway Hypertension (IF 8.3) Pub Date : 2024-01-04 Yan-Zhen Huang, Ji-Chun Wu, Gui-Feng Lu, Hui-Bin Li, Su-Mei Lai, Yi-Chen Lin, Long-Xin Gui, James S.K. Sham, Mo-Jun Lin, Da-Cen Lin
BACKGROUND:Clinical evidence revealed abnormal prevalence of coronary artery (CA) disease in patients with pulmonary hypertension (PH). The mechanistic connection between PH and CA disease is unclear. Serotonin (5-hydroxytryptamine), reactive oxygen species, and Ca2+ signaling have been implicated in both PH and CA disease. Our recent study indicates that NOXs (NADPH [nicotinamide adenine dinucleotide
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Vascular Inflammation and Smooth Muscle Contractility: The Role of Nox1-Derived Superoxide and LRRC8 Anion Channels Hypertension (IF 8.3) Pub Date : 2024-01-04 Fred S. Lamb, Hyehun Choi, Michael R. Miller, Ryan J. Stark
Vascular inflammation underlies the development of hypertension, and the mechanisms by which it increases blood pressure remain the topic of intense investigation. Proinflammatory factors including glucose, salt, vasoconstrictors, cytokines, wall stress, and growth factors enhance contractility and impair relaxation of vascular smooth muscle cells. These pathways share a dependence upon redox signaling
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Recent Advances in Understanding Peripheral and Gut Immune Cell-Mediated Salt-Sensitive Hypertension and Nephropathy Hypertension (IF 8.3) Pub Date : 2024-01-02 Mohammad Saleem, Sepiso K. Masenga, Jeanne A. Ishimwe, Mert Demirci, Taseer Ahmad, Sydney Jamison, Claude F. Albritton, Naome Mwesigwa, Alexandria Porcia Haynes, Jalyn White, Kit Neikirk, Zer Vue, Antentor Hinton Jr, Suha Arshad, Selam Desta, Annet Kirabo
Hypertension is the primary modifiable risk factor for cardiovascular, renal, and cerebrovascular diseases and is considered the main contributing factor to morbidity and mortality worldwide. Approximately 50% of hypertensive and 25% of normotensive people exhibit salt sensitivity of blood pressure, which is an independent risk factor for cardiovascular disease. Human and animal studies demonstrate
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Effect of Intensive Blood Pressure Control on Cardiovascular Outcomes in Cancer Survivors Hypertension (IF 8.3) Pub Date : 2024-01-02 Wenjie Li, Zhiyan Wang, Chao Jiang, Chang Hua, Yangyang Tang, Hao Zhang, Xinru Liu, Shiyue Zheng, Yufeng Wang, Mingyang Gao, Qiang Lv, Jianzeng Dong, Changsheng Ma, Xin Du
BACKGROUND:To evaluate whether cancer modifies the effect of intensive blood pressure control on major cardiovascular outcomes.METHODS:Using data of the SPRINT (Systolic Blood Pressure Intervention Trial), we compared the risk of the composite outcomes of myocardial infarction, other acute coronary syndromes, stroke, heart failure, and cardiovascular death in patients with and without a history of
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KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure Hypertension (IF 8.3) Pub Date : 2024-01-02 Xiaobin Han, Leah Akinseye, Zhongjie Sun
BACKGROUND:KDM6A (Lysine-Specific Demethylase 6A) is a specific demethylase for histone 3 lysine (K) 27 trimethylation (H3K27me3). The purpose of this study is to investigate whether KDM6A in renal tubule cells plays a role in the regulation of kidney function and blood pressure.METHODS:We first crossed Ksp-Cre+/− and KDM6Aflox/flox mice for generating inducible kidney-specific deletion of KDM6A gene
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Pharmacological Inhibition of Epidermal Growth Factor Receptor Prevents Intracranial Aneurysm Rupture by Reducing Endoplasmic Reticulum Stress Hypertension (IF 8.3) Pub Date : 2024-01-02 Taichi Ishiguro, Hajime Furukawa, Kyle Polen, Yushiro Take, Hiroki Sato, Daisuke Kudo, Jordan Morgan, Hiroki Uchikawa, Takuma Maeda, Oscar Cisneros, Redi Rahmani, Jinglu Ai, Satoru Eguchi, Michael T. Lawton, Tomoki Hashimoto
BACKGROUND:Multiple pathways and factors are involved in the rupture of intracranial aneurysms. The EGFR (epidermal growth factor receptor) has been shown to mediate inflammatory vascular diseases, including atherosclerosis and aortic aneurysm. However, the role of EGFR in mediating intracranial aneurysm rupture and its underlying mechanisms have yet to be determined. Emerging evidence indicates that
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Blood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke Hypertension (IF 8.3) Pub Date : 2024-01-02 Aristeidis H. Katsanos, Raed A. Joundi, Lina Palaiodimou, Niaz Ahmed, Joon-Tae Kim, Nitin Goyal, Ilko L. Maier, Adam de Havenon, Mohammad Anadani, Marius Matusevicius, Eva A. Mistry, Pooja Khatri, Adam S. Arthur, Amrou Sarraj, Shadi Yaghi, Ashkan Shoamanesh, Luciana Catanese, Marios-Nikos Psychogios, Konstantinos Tsioufis, Konark Malhotra, Alejandro M. Spiotta, Else Charlotte Sandset, Andrei V. Alexandrov
BACKGROUND:Data on systolic blood pressure (SBP) trajectories in the first 24 hours after endovascular thrombectomy (EVT) in acute ischemic stroke are limited. We sought to identify these trajectories and their relationship to outcomes.METHODS:We combined individual-level data from 5 studies of patients with acute ischemic stroke who underwent EVT and had individual blood pressure values after the
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KCNQ5 Controls Perivascular Adipose Tissue–Mediated Vasodilation Hypertension (IF 8.3) Pub Date : 2023-12-28 Dmitry Tsvetkov, Johanna Schleifenbaum, Yibin Wang, Mario Kassmann, Maya M. Polovitskaya, Mohamed Ali, Sebastian Schütze, Michael Rothe, Friedrich C. Luft, Thomas J. Jentsch, Maik Gollasch
BACKGROUND:Small arteries exhibit resting tone, a partially contracted state that maintains arterial blood pressure. In arterial smooth muscle cells, potassium channels control contraction and relaxation. Perivascular adipose tissue (PVAT) has been shown to exert anticontractile effects on the blood vessels. However, the mechanisms by which PVAT signals small arteries, and their relevance remain largely
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Fetal Sexual Dimorphism and Preeclampsia Among Twin Pregnancies Hypertension (IF 8.3) Pub Date : 2023-12-28 Rebekah E. Brown, Akaninyene I. Noah, Ashley V. Hill, Brandie D. Taylor
BACKGROUND:In singleton pregnancies, fetal sexual dimorphism has been observed in hypertensive disorders of pregnancy, particularly preeclampsia, a morbid syndrome that increases the risk of adult-onset cardiovascular disease for mothers and their offspring. However, few studies have explored the effect of fetal sex on hypertensive disorders of pregnancy among twin pregnancies.METHODS:We conducted
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Cardiovascular Complications in Pheochromocytoma and Paraganglioma: Does Phenotype Matter? Hypertension (IF 8.3) Pub Date : 2023-12-28 Ondřej Petrák, Zuzana Krátká, Robert Holaj, Matěj Zítek, Thi Nguyen Nikrýnová, Judita Klímová, Barbora Kološová, Petr Waldauf, David Michalský, Květoslav Novák, Alice Markvartová, Lukáš Zlatohlávek, Tomáš Grus, Jaroslava Dušková, Jiří Widimský Jr, Tomáš Zelinka
BACKGROUND:Adrenaline-producing tumors are mostly characterized by a sudden release of catecholamines with episodic symptoms. Noradrenergic ones are usually less symptomatic and characterized by a continuous overproduction of catecholamines that are released into the bloodstream. Their effects on the cardiovascular system can thus be different. The aim of this study was to determine the prevalence
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Precision Hypertension Hypertension (IF 8.3) Pub Date : 2023-12-19 Victor J. Dzau, Conrad P. Hodgkinson
Hypertension affects >1 billion people worldwide. Complications of hypertension include stroke, renal failure, cardiac hypertrophy, myocardial infarction, and cardiac failure. Despite the development of various antihypertensive drugs, the number of people with uncontrolled hypertension continues to rise. While the lack of compliance associated with frequent side effects to medication is a contributory
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Tangram of Sodium and Fluid Balance Hypertension (IF 8.3) Pub Date : 2023-12-12 Domenico Bagordo, Gian Paolo Rossi, Christian Delles, Helge Wiig, Giacomo Rossitto
Homeostasis of fluid and electrolytes is a tightly controlled physiological process. Failure of this process is a hallmark of hypertension, chronic kidney disease, heart failure, and other acute and chronic diseases. While the kidney remains the major player in the control of whole-body fluid and electrolyte homeostasis, recent discoveries point toward more peripheral mechanisms leading to sodium storage
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Endothelin System in Hypertension and Chronic Kidney Disease Hypertension (IF 8.3) Pub Date : 2023-12-07 Ernesto L. Schiffrin, David M. Pollock
ET (endothelin) is a powerful vasoconstrictor 21-amino acid peptide present in many tissues, which exerts many physiological functions across the body and participates as a mediator in many pathological conditions. ETs exert their effects through ETA and ETB receptors, which can be blocked by selective receptor antagonists. ETs were shown to play important roles among others, in systemic hypertension
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Histone Modifications and Their Contributions to Hypertension. Hypertension (IF 8.3) Pub Date : 2023-11-30 Atrayee Ray,Cary Stelloh,Yong Liu,Alison Meyer,Aron M Geurts,Allen Cowley,Andrew S Greene,Mingyu Liang,Sridhar Rao
Essential hypertension, a multifaceted disorder, is a worldwide health problem. A complex network of genetic, epigenetic, physiological, and environmental components regulates blood pressure (BP), and any dysregulation of this network may result in hypertension. Growing evidence suggests a role for epigenetic factors in BP regulation. Any alterations in the expression or functions of these epigenetic
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Striatin Gene Variants Are Associated With Salt Sensitivity of Blood Pressure by Mechanisms That Differ in Women and Men. Hypertension (IF 8.3) Pub Date : 2023-11-29 Shadi K Gholami,Mahyar Heydarpour,Jonathan S Williams,Luminita H Pojoga,Gail K Adler,Gordon H Williams,Jose R Romero
BACKGROUND Salt sensitivity of blood pressure (SSBP) is a substantial risk factor for cardiovascular morbidity and mortality. STRN (striatin) is critical for estrogen and aldosterone nongenomic signaling. However, the role of biological sex on the SSBP phenotype associated with STRN gene variants remains unexplored. METHOD Data from 1306 subjects participating in the Hypertensive Pathotype (HyperPATH)
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Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia. Hypertension (IF 8.3) Pub Date : 2023-11-29 Katie A O'Brien,Wanjun Gu,Julie A Houck,Lorenz M W Holzner,Hong Wa Yung,Jenna L Armstrong,Alice P Sowton,Ruby Baxter,Paula M Darwin,Lilian Toledo-Jaldin,Litzi Lazo-Vega,Any Moreno-Aramayo,Valquiria Miranda-Garrido,Jonathan A Shortt,Christopher J Matarazzo,Hussna Yasini,Graham J Burton,Lorna G Moore,Tatum S Simonson,Andrew J Murray,Colleen Glyde Julian
BACKGROUND The chronic hypoxia of high-altitude residence poses challenges for tissue oxygen supply and metabolism. Exposure to high altitude during pregnancy increases the incidence of hypertensive disorders of pregnancy and fetal growth restriction and alters placental metabolism. High-altitude ancestry protects against altitude-associated fetal growth restriction, indicating hypoxia tolerance that
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Obesity in Hypertension: The Role of the Expanding Waistline Over the Years and Insights Into the Future. Hypertension (IF 8.3) Pub Date : 2023-11-29 Guanghong Jia,James R Sowers,Adam Whaley-Connell
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Tail-Cuff Versus Radiotelemetry to Measure Blood Pressure in Mice and Rats. Hypertension (IF 8.3) Pub Date : 2023-11-22 D G Harrison,M Bader,L O Lerman,G Fink,S A Karumanchi,J F Reckelhoff,M L S Sequeira-Lopez,R M Touyz
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Rethinking Culture to Unlock the Potential of Medical Research. Hypertension (IF 8.3) Pub Date : 2023-11-22 Francine Z Marques
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Nocturnal Hypertension and Left Ventricular Diastolic Dysfunction in Patients With Diabetes With the Absence of Heart Failure: Prospective Cohort HSCAA Study. Hypertension (IF 8.3) Pub Date : 2023-11-22 Yonekazu Kidawara,Manabu Kadoya,Masataka Igeta,Akiko Morimoto,Akio Miyoshi,Miki Kakutani-Hatayama,Akinori Kanzaki,Kosuke Konishi,Yoshiki Kusunoki,Takashi Daimon,Masanori Asakura,Masaharu Ishihara,Hidenori Koyama
BACKGROUND Diabetes is an important risk factor for heart failure (HF) and is associated with left ventricular (LV) diastolic dysfunction. However, diabetic comorbid conditions, such as nocturnal hypertension, as predictors of diastolic dysfunction are not known in the absence of an HF period. The present study was conducted as the longitudinal examination of the predictive value of nocturnal hypertension
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2024 Recommendations for Validation of Noninvasive Arterial Pulse Wave Velocity Measurement Devices. Hypertension (IF 8.3) Pub Date : 2023-11-17 Bart Spronck,Dimitrios Terentes-Printzios,Alberto P Avolio,Pierre Boutouyrie,Andrea Guala,Ana Jerončić,Stéphane Laurent,Eduardo C D Barbosa,Johannes Baulmann,Chen-Huan Chen,Julio A Chirinos,Stella S Daskalopoulou,Alun D Hughes,Azra Mahmud,Christopher C Mayer,Jeong Bae Park,Gary L Pierce,Aletta E Schutte,Elaine M Urbina,Ian B Wilkinson,Patrick Segers,James E Sharman,Isabella Tan,Charalambos Vlachopoulos
BACKGROUND Arterial stiffness, as measured by arterial pulse wave velocity (PWV), is an established biomarker for cardiovascular risk and target-organ damage in individuals with hypertension. With the emergence of new devices for assessing PWV, it has become evident that some of these devices yield results that display significant discrepancies compared with previous devices. This discrepancy underscores
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The Apples and Oranges of Blood Pressure Variability. Hypertension (IF 8.3) Pub Date : 2023-11-15 John W McEvoy,Niall Leahy,Gianfranco Parati