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Voluntary Exercise Eliminates Maternal Gestational Hypertension–Induced Hypertensive Response Sensitization to Postweaning High-Fat Diet in Male Adult Offspring Hypertension (IF 10.19) Pub Date : 2022-06-22 Baojian Xue, Yang Yu, Terry G. Beltz, Fang Guo, Shun-Guang Wei, Alan Kim Johnson
BACKGROUND:Exercise has profound effects on cardiovascular function and metabolism in both physiological and pathophysiological states. The present study tested whether voluntary exercise would protect male offspring against maternal gestational hypertension-induced hypertensive response sensitization elicited by post-weaning high-fat diet (HFD).METHODS AND RESULTS:On low-lard-fat diet, offspring of
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Cathepsin K Deficiency Prevented Kidney Damage and Dysfunction in Response to 5/6 Nephrectomy Injury in Mice With or Without Chronic Stress Hypertension (IF 10.19) Pub Date : 2022-06-21 Xueling Yue, Limei Piao, Hailong Wang, Zhe Huang, Xiangkun Meng, Takeshi Sasaki, Aiko Inoue, Kae Nakamura, Ying Wan, Shengnan Xu, Guo-Ping Shi, Weon Kim, Toyoaki Murohara, Masafumi Kuzuya, Xian Wu Cheng
BACKGROUND:Chronic psychological stress is a risk factor for kidney disease, including kidney dysfunction and hypertension. Lysosomal CatK (cathepsin K) participates in various human pathobiologies. We investigated the role of CatK in kidney remodeling and hypertension in response to 5/6 nephrectomy injury in mice with or without chronic stress.METHODS:Male 7-week-old WT (wild type; CatK+/+) and CatK-deficient
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Digital Therapeutics in Hypertension: Evidence and Perspectives Hypertension (IF 10.19) Pub Date : 2022-06-21 Kazuomi Kario, Noriko Harada, Ayako Okura
Digital therapeutics refers to the use of evidence-based therapeutic interventions driven by high-quality software programs to treat, manage, or prevent a medical condition. This approach is being increasingly investigated for the management of hypertension, a common condition that is the leading preventable cardiovascular disease risk factor worldwide. Digital interventions can help facilitate uptake
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Variation in Mean Arterial Pressure Increases Falls Risk in Elderly Physically Frail and Prefrail Individuals Treated With Antihypertensive Medication Hypertension (IF 10.19) Pub Date : 2022-06-20 Sultana Monira Hussain, Michael E. Ernst, Anna L. Barker, Karen L. Margolis, Christopher M. Reid, Johannes T. Neumann, Andrew M. Tonkin, Thao Le Thi Phuong, Lawrence J Beilin, Thao Pham, Enayet K. Chowdhury, Flavia M. Cicuttini, Julia Gilmartin-Thomas, Prudence R. Carr, John J McNeil
Background:Impaired cerebral blood flow has been associated with an increased risk of falls. Mean arterial pressure (MAP) and variability in MAP have been reported to affect cerebral blood flow but their relationships to the risk of falls have not previously been reported.Methods:Utilising data from the aspirin in Reducing Events in the Elderly trial participants, we estimated MAP and variability in
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Revascularization for Renovascular Disease: A Scientific Statement From the American Heart Association Hypertension (IF 10.19) Pub Date : 2022-06-16 Vivek Bhalla, Stephen C. Textor, Joshua A. Beckman, Ana I. Casanegra, Christopher J. Cooper, Esther S.H. Kim, James M. Luther, Sanjay Misra, Gustavo S. Oderich, on behalf of the American Heart Association Council on the Kidney in Cardiovascular Disease, Council on Hypertension, Council on Peripheral Vascular Disease, and Council on Cardiovascular Radiology and Intervention
Renovascular disease is a major causal factor for secondary hypertension and renal ischemic disease. However, several prospective, randomized trials for atherosclerotic disease failed to demonstrate that renal revascularization is more effective than medical therapy for most patients. These results have greatly reduced the generalized diagnostic workup and use of renal revascularization. Most guidelines
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Effects of a Liquefied Petroleum Gas Stove Intervention on Gestational Blood Pressure: Intention-to-Treat and Exposure-Response Findings From the HAPIN Trial Hypertension (IF 10.19) Pub Date : 2022-06-16 Wenlu Ye, Kyle Steenland, Ashlinn Quinn, Jiawen Liao, Kalpana Balakrishnan, Ghislaine Rosa, Florien Ndagijimana, Jean de Dieu Ntivuguruzwa, Lisa M. Thompson, John P. McCracken, Anaité Díaz-Artiga, Joshua P. Rosenthal, Aris Papageorghiou, Victor G. Davila-Roman, Ajay Pillarisetti, Michael Johnson, Jiantong Wang, Laura Nicolaou, William Checkley, Jennifer L. Peel, Thomas F. Clasen, for the Household
Background:Approximately 3 to 4 billion people worldwide are exposed to household air pollution, which has been associated with increased blood pressure (BP) in pregnant women in some studies.Methods:We recruited 3195 pregnant women in Guatemala, India, Peru, and Rwanda and randomly assigned them to intervention or control groups. The intervention group received a gas stove and fuel during pregnancy
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Control of Blood Pressure and Risk of Cardiovascular Disease and Mortality in Elderly Chinese: A Real-World Prospective Cohort Study Hypertension (IF 10.19) Pub Date : 2022-06-15 Anxin Wang, Xue Tian, Yingting Zuo, Shuohua Chen, Yijun Zhang, Xiaoli Zhang, Xuan Deng, Qin Xu, Penglian Wang, Shouling Wu, Yong Zhou
BACKGROUND:The STEP trial (Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients) showed that older hypertensive patients might benefit from a target systolic blood pressure (SBP) of 110 to <130 mm Hg. We examined whether this target SBP is associated with a decreased risk of cardiovascular disease (CVD) and all-cause mortality among elderly Chinese in real-world settings.METHODS:This
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SGLT2 Inhibition via Empagliflozin Improves Endothelial Function and Reduces Mitochondrial Oxidative Stress: Insights From Frail Hypertensive and Diabetic Patients Hypertension (IF 10.19) Pub Date : 2022-06-15 Pasquale Mone, Fahimeh Varzideh, Stanislovas S. Jankauskas, Antonella Pansini, Angela Lombardi, Salvatore Frullone, Gaetano Santulli
BACKGROUND:Frailty is a multidimensional condition often diagnosed in older adults with hypertension and diabetes, and both these conditions are associated with endothelial dysfunction and oxidative stress. We investigated the role of the SGLT2 (sodium glucose cotransporter 2) inhibitor empagliflozin on cognitive frailty in diabetic and hypertensive older adults.METHODS:We studied the effects of empagliflozin
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Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation Hypertension (IF 10.19) Pub Date : 2022-06-13 Ning Ding, Carrie A. Karvonen-Gutierrez, Bhramar Mukherjee, Antonia M. Calafat, Siobán D. Harlow, Sung Kyun Park
Background:Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are ubiquitous synthetic chemicals that may disrupt blood pressure controls; however, human evidence to support this hypothesis is scant. We examined the association between serum concentrations of PFAS and risks of developing hypertension.Methods:This study included 1058 midlife women initially free of hypertension from the multiracial
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Management and Outcomes of Primary Aldosteronism in Pregnancy: A Systematic Review Hypertension (IF 10.19) Pub Date : 2022-06-10 Viola Sanga, Giacomo Rossitto, Teresa Maria Seccia, Gian Paolo Rossi
Primary aldosteronism (PA) in pregnancy (PAP) can be a serious condition and is challenging to diagnose. This study was conceived to help in the diagnosis of PAP and provide suggestions on management of PAP based on evidence retrieved using a Population, Intervention, Comparison, and Outcome search strategy. Based on the changes of aldosterone and renin occurring in normal pregnancies, we developed
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IsoLGs (Isolevuglandins) Drive Neutrophil Migration in Hypertension and Are Essential for the Formation of Neutrophil Extracellular Traps Hypertension (IF 10.19) Pub Date : 2022-06-10 Jaya Krishnan, Néstor de la Visitación, Elizabeth M. Hennen, Venkataraman Amarnath, David G. Harrison, David M. Patrick
BACKGROUND:IsoLGs (isolevuglandins) are electrophilic products of lipid peroxidation formed in the presence of reactive oxygen species. IsoLGs contribute to hypertension by an unknown mechanism. Studies have shown that reactive oxygen species production drives the formation of neutrophil extracellular traps (NETs) and that NETs accumulate within the aorta and kidneys of patients with hypertension.
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Effects of Ramipril on Biomarkers of Endothelial Dysfunction and Inflammation in Hypertensive Children on Maintenance Hemodialysis: the SEARCH Randomized Placebo-Controlled Trial Hypertension (IF 10.19) Pub Date : 2022-06-10 Areej Mohamed Ateya, Ihab El Hakim, Sara Mahmoud Shahin, Radwa El Borolossy, Reinhold Kreutz, Nagwa Ali Sabri
BACKGROUND:Hypertension, endothelial dysfunction, and inflammation are associated with increased cardiovascular mortality in end-stage kidney disease. We evaluated the effects of ACE (angiotensin-converting enzyme) inhibition on biomarkers of endothelial dysfunction and inflammation in hypertensive children with end-stage kidney disease on maintenance hemodialysis.METHODS:In a randomized, double-blind
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Correction to: Prospective Evaluation of International Prediction of Pregnancy Complications Collaborative Network Models for Prediction of Preeclampsia: Role of Serum sFlt-1 at 11–13 Weeks’ Gestation Hypertension (IF 10.19) Pub Date : 2022-06-08
In the article by Chaiyasit et al, “Prospective Evaluation of International Prediction of Pregnancy Complications Collaborative Network Models for Prediction of Preeclampsia: Role of Serum sFlt-1 at 11–13 Weeks’ Gestation,” which published in the February 2022 issue (Hypertension. 2022;79:314–322. doi:/10.1161/HYPERTENSIONAHA.121.18021), a correction was needed. An error was made in Table 2 and did
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Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway Hypertension (IF 10.19) Pub Date : 2022-06-08 Xiaoliang Jiang, Yunpeng Liu, Xin-Yang Zhang, Xue Liu, Xing Liu, Xianxian Wu, Pedro A. Jose, Shun Duan, Fu-Jian Xu, Zhiwei Yang
Background:The present study directly tested the crucial role of intestinal gastrin/CCKBR (cholecystokinin B receptor) in the treatment of salt-sensitive hypertension.Methods:Adult intestine-specific Cckbr-knockout mice (Cckbrfl/flvillin-Cre) and Dahl salt-sensitive rats were studied on the effect of high salt intake (8% NaCl, 6–7 weeks) on intestinal Na+/H+ exchanger 3 expression, urine sodium concentration
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MANP (Mutant Atrial Natriuretic Peptide) Activation of the cGMP (3’,5’, Cyclic Guanosine Monophosphate) Inhibits Aldosterone via PDE2 (Phosphodiesterase 2) and Cytochrome p450 Family 11 Subfamily b Member 2 in H295R Cells and in Mice Hypertension (IF 10.19) Pub Date : 2022-06-08 Yang Chen, Seethalakshmi R. Iyer, Viacheslav O. Nikolaev, Fabio Naro, Manuela Pellegrini, Silvia Cardarelli, Xiao Ma, Hon-Chi Lee, John C. Burnett Jr
BACKGROUND:Aldosterone is a critical pathological driver for cardiac and renal diseases. We recently discovered that MANP (mutant atrial natriuretic peptide), a novel ANP (atrial natriuretic peptide) analog, possessed more potent aldosterone inhibitory action than ANP in vivo. MANP and NP (natriuretic peptide)-augmenting therapy sacubitril/valsartan are under investigations for human hypertension treatment
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Association Between the Gut Microbiome and Their Metabolites With Human Blood Pressure Variability Hypertension (IF 10.19) Pub Date : 2022-06-08 Evany Dinakis, Michael Nakai, Paul Gill, Rosilene Ribeiro, Stephanie Yiallourou, Yusuke Sata, Jane Muir, Melinda Carrington, Geoffrey A. Head, David M. Kaye, Francine Z. Marques
BACKGROUND:Blood pressure (BP) variability is an independent risk factor for cardiovascular events. Recent evidence supports a role for the gut microbiota in BP regulation. However, whether the gut microbiome is associated with BP variability is yet to be determined. Here, we aimed to investigate the interplay between the gut microbiome and their metabolites in relation to BP variability.METHODS:Ambulatory
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Uric Acid and Hypertension: a Review of Evidence and Future Perspectives for the Management of Cardiovascular Risk Hypertension (IF 10.19) Pub Date : 2022-06-06 Claudio Borghi, Davide Agnoletti, Arrigo Francesco Giuseppe Cicero, Empar Lurbe, Agostino Virdis
Uric acid is the final product of purine metabolism, and its increased serum levels have been directly involved in the pathogenesis and natural history of hypertension. The relationship between elevated uric acid and hypertension has been proven in both animals and humans, and its relevance is already evident in childhood and adolescent population. The mechanism responsible for blood pressure increase
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Uric Acid Expression in Carotid Atherosclerotic Plaque and Serum Uric Acid Are Associated With Cerebrovascular Events Hypertension (IF 10.19) Pub Date : 2022-06-03 Valentina Nardi, Federico Franchi, Megha Prasad, Erica M. Fatica, Mariam P. Alexander, Melanie C. Bois, Josephine Lam, Ravinder J. Singh, Fredric B. Meyer, Giuseppe Lanzino, Yuning Xiong, Esther Lutgens, Lilach O. Lerman, Amir Lerman
Background:Uric acid (UA) concentration within carotid plaque and its association with cerebrovascular events have not been detected or quantified. Systemically, serum UA is a marker of inflammation and risk factor for atherosclerosis. However, its association with carotid plaque instability and stroke pathogenesis remains unclear. In patients undergoing carotid endarterectomy, we aimed to determine
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Effect of Renin-Angiotensin-Aldosterone System Inhibitors on the Rupture Risk Among Hypertensive Patients With Intracranial Aneurysms Hypertension (IF 10.19) Pub Date : 2022-06-03 Ping Zhong, Zhiwen Lu, Zhangyu Li, Tianxiao Li, Qing Lan, Jianmin Liu, Zhanxiang Wang, Sifang Chen, Qinghai Huang
Background:Mounting experimental evidence supports the concept that the RAAS (renin-angiotensin-aldosterone system) is involved in the pathogenesis of intracranial aneurysm rupture. However, whether RAAS inhibitors could reduce the rupture risk of intracranial aneurysms remains unclear.Methods:We performed a chart review of a multicenter, prospectively maintained database of 3044 hypertensive patients
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Longitudinal Changes in Cardiac Structure and Function in Pediatric Kidney Transplant Recipients Hypertension (IF 10.19) Pub Date : 2022-06-02 Isabel de Verteuil, Jessica Fitzpatrick, Ana Catalina Alvarez Elias, Tonny Banh, Jovanka Vasilevska-Ristovska, Jordan Browne, Bianca C. Bondi, Wei Hui, Cameron Slorach, Chia Wei Teoh, Valerie Langlois, Luc Mertens, Rulan S. Parekh
Background:Cardiovascular disease results in increased morbidity and mortality in pediatric kidney transplant recipients. Longitudinal changes in cardiac structure and function and the association with blood pressure control over time in pediatric kidney transplant recipients are unknown.Methods:To determine the influence of blood pressure control on cardiac changes following pediatric kidney transplant
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Dapagliflozin Attenuates Sympathetic and Pressor Responses to Stress in Young Prehypertensive Spontaneously Hypertensive Rats Hypertension (IF 10.19) Pub Date : 2022-06-02 Han-Kyul Kim, Rie Ishizawa, Ayumi Fukazawa, Zhongyun Wang, Ursa Bezan Petric, Ming Chang Hu, Scott A. Smith, Masaki Mizuno, Wanpen Vongpatanasin
Background:SGLT2i (sodium-glucose cotransporter 2 inhibitor), a class of anti-diabetic medications, is shown to reduce blood pressure (BP) in hypertensive patients with type 2 diabetes. Mechanisms underlying this action are unknown but SGLT2i-induced sympathoinhibition is thought to play a role. Whether SGLT2i reduces BP and sympathetic nerve activity (SNA) in a nondiabetic prehypertension model is
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Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension Hypertension (IF 10.19) Pub Date : 2022-06-02 Tanika N. Kelly, Xiao Sun, Karen Y. He, Michael R. Brown, Sarah A. Gagliano Taliun, Jacklyn N. Hellwege, Marguerite R. Irvin, Xuenan Mi, Jennifer A. Brody, Nora Franceschini, Xiuqing Guo, Shih-Jen Hwang, Paul S. de Vries, Yan Gao, Arden Moscati, Girish N. Nadkarni, Lisa R. Yanek, Tali Elfassy, Jennifer A. Smith, Ren-Hua Chung, Amber L. Beitelshees, Amit Patki, Stella Aslibekyan, Brandon M. Blobner
Background:The availability of whole-genome sequencing data in large studies has enabled the assessment of coding and noncoding variants across the allele frequency spectrum for their associations with blood pressure.Methods:We conducted a multiancestry whole-genome sequencing analysis of blood pressure among 51 456 Trans-Omics for Precision Medicine and Centers for Common Disease Genomics program
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Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis Hypertension (IF 10.19) Pub Date : 2022-06-02 Alexander A. Leung, Christopher J. Symonds, Gregory L. Hundemer, Paul E. Ronksley, Diane L. Lorenzetti, Janice L. Pasieka, Adrian Harvey, Gregory A. Kline
Background:Confirmatory tests are recommended for diagnosing primary aldosteronism, but the supporting evidence is unclear.Methods:We searched Medline, EMBASE, and the Cochrane Central Register of Controlled Trials. Studies evaluating any guideline-recommended confirmatory test (ie, saline infusion test, salt loading test, fludrocortisone suppression test, and captopril challenge test), compared with
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Novel Drug Delivery Technologies and Targets for Renal Disease Hypertension (IF 10.19) Pub Date : 2022-06-02 Alejandro R. Chade, Gene L. Bidwell III
The burden of acute and chronic kidney diseases to the health care system is exacerbated by the high mortality that this disease carries paired with the still limited availability of comprehensive therapies. A reason partially resides in the complexity of the kidney, with multiple potential target cell types and a complex structural environment that complicate strategies to protect and recover renal
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How to Improve Awareness, Treatment, and Control of Hypertension in Africa, and How to Reduce Its Consequences. A Call to Action From the World Hypertension League Hypertension (IF 10.19) Pub Date : 2022-05-31 Gianfranco Parati, Daniel T. Lackland, Norman R.C. Campbell, Mayowa Ojo Owolabi, Charlotte Bavuma, Hind Mamoun Beheiry, Anastase Dzudie, Moshen Ibrahim, Wafaa El Aroussy, Sandhya Singh, Cherian V. Varghese, Paul K. Whelton, Xin-Hua Zhang, on behalf of the World Hypertension league
Hypertension is the leading preventable risk factor for cardiovascular diseases and disability globally. In low- and middle-income countries hypertension has a major social impact, increasing the disease burden and costs for national health systems. The present call to action aims to stimulate all African countries to adopt several solutions to achieve better hypertension management. The following
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Blood Pressure Control Among US Adults, 2009 to 2012 Through 2017 to 2020 Hypertension (IF 10.19) Pub Date : 2022-05-26 Paul Muntner, Miriam A. Miles, Byron C. Jaeger, Lonnie Hannon III, Shakia T. Hardy, Yechiam Ostchega, Gregory Wozniak, Joseph E. Schwartz
Background:The National Health and Nutrition Examination Survey data indicate that the proportion of US adults with hypertension that had controlled blood pressure (BP) declined from 2013 to 2014 through 2017 to 2018. We analyzed data from National Health and Nutrition Examination Survey 2009 to 2012, 2013 to 2016, and 2017 to 2020 to confirm this finding.Methods:Hypertension was defined as systolic
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Effects of Blood Pressure According to Age on End-Stage Renal Disease Development in Patients With Patients With Diabetes: A Nationwide Population-Based Cohort Study Hypertension (IF 10.19) Pub Date : 2022-05-24 Eun Hui Bae, Sang Yeob Lim, Bongseong Kim, Tae Ryom Oh, Su Hyun Song, Sang Heon Suh, Hong Sang Choi, Eun Mi Yang, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
Background:Recent hypertension guidelines have recommended lower blood pressure (BP) targets in high-risk patients. However, there are no specific guidelines based on age or systolic and diastolic blood pressure (SBP and DBP, respectively). We aimed to assess the effects of age-related BP on development of end-stage renal disease (ESRD) in patients with diabetes.Methods:A total of 2 563 870 patients
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Evidence From Human Placenta, Endoplasmic Reticulum–Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia Hypertension (IF 10.19) Pub Date : 2022-05-24 Shibin Cheng, Zheping Huang, Sayani Banerjee, Sukanta Jash, Joel N. Buxbaum, Surendra Sharma
Background:We have demonstrated that protein aggregation plays a pivotal role in the pathophysiology of preeclampsia and identified several aggregated proteins in the circulation of preeclampsia patients, the most prominent of which is the serum protein TTR (transthyretin). However, the mechanisms that underlie protein aggregation remain poorly addressed.Methods:We examined TTR aggregates in hypox
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Markers of Focal and Diffuse Nonischemic Myocardial Fibrosis Are Associated With Adverse Cardiac Remodeling and Prognosis in Patients With Hypertension: The REMODEL Study Hypertension (IF 10.19) Pub Date : 2022-05-23 Nithin R. Iyer, Thu-Thao Le, Michelle S.L. Kui, Hak-Chiaw Tang, Chee-Tang Chin, Soon-Kieng Phua, Jennifer A. Bryant, Chee-Jian Pua, Briana Ang, Desiree-Faye Toh, Tar-Choon Aw, Chi-Hang Lee, Stuart A. Cook, Martin Ugander, Calvin W.L. Chin
BACKGROUND:The prognostic significance of focal and diffuse myocardial fibrosis in patients with cardiovascular risk factors is unclear.METHODS:REMODEL (Response of the Myocardium to Hypertrophic Conditions in the Adult Population) is an observational cohort of asymptomatic patients with essential hypertension. All participants underwent cardiovascular magnetic resonance to assess for myocardial fibrosis:
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Ambulatory Blood Pressure Monitoring in Children and Adolescents: 2022 Update: A Scientific Statement From the American Heart Association Hypertension (IF 10.19) Pub Date : 2022-05-23 Joseph T. Flynn, Elaine M. Urbina, Tammy M. Brady, Carissa Baker-Smith, Stephen R. Daniels, Laura L. Hayman, Mark Mitsnefes, Andrew Tran, Justin P. Zachariah, on behalf of the Atherosclerosis, Hypertension, and Obesity in the Young Committee of the American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young, Council on Cardiovascular Radiology and Intervention
Use of ambulatory blood pressure monitoring in children and adolescents has markedly increased since publication of the last American Heart Association scientific statement on pediatric ambulatory blood pressure monitoring in 2014. In addition, there has also been significant expansion of the evidence base for use of ambulatory blood pressure monitoring in the pediatric population, including new data
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Puberty Timing and Sex-Specific Trajectories of Systolic Blood Pressure: a Prospective Cohort Study Hypertension (IF 10.19) Pub Date : 2022-05-19 Kate N. O’Neill, Joshua A. Bell, George Davey Smith, Kate Tilling, Patricia M. Kearney, Linda M. O’Keeffe
Background:Sex differences in systolic blood pressure (SBP) emerge during adolescence but the role of puberty is not well understood. We examined sex-specific changes in SBP preceding and following puberty and examined the impact of puberty timing on SBP trajectories in females and males.Methods:Trajectories of SBP before and after puberty and by timing of puberty in females and males in a contemporary
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Reshaping the Preterm Heart: Shifting Cardiac Renin-Angiotensin System Towards Cardioprotection in Rats Exposed to Neonatal High-Oxygen Stress Hypertension (IF 10.19) Pub Date : 2022-05-19 Mariane Bertagnolli, Daniela R. Dartora, Pablo Lamata, Ernesto Zacur, Thuy-An Mai Vo, Ying He, Léonie Beauchamp, Adam J. Lewandowski, Anik Cloutier, Megan R. Sutherland, Robson A.S. Santos, Anne Monique Nuyt
Background:Approximately 10% of infants are born preterm. Preterm birth leads to short and long-term changes in cardiac shape and function. By using a rat model of neonatal high-oxygen (80%O2) exposure, mimicking the premature hyperoxic transition to the extrauterine environment, we revealed a major role of the renin-angiotensin system peptide Angio II (angiotensin II) and its receptor AT1 (angiotensin
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Cardiac Structure and Function Across the Spectrum of Aldosteronism: the Atherosclerosis Risk in Communities Study Hypertension (IF 10.19) Pub Date : 2022-05-18 Jenifer M. Brown, Magnus O. Wijkman, Brian L. Claggett, Amil M. Shah, Christie M. Ballantyne, Josef Coresh, Morgan E. Grams, Zhiying Wang, Bing Yu, Eric Boerwinkle, Anand Vaidya, Scott D. Solomon
Background:Aldosterone production and mineralocorticoid receptor activation are implicated in myocardial fibrosis and cardiovascular events.Methods:Cardiac structure and function were assessed in 4547 participants without prevalent heart failure (HF) in the ARIC study (Atherosclerosis Risk in Communities), with echocardiography, aldosterone, and plasma renin activity measurement (2011–2013). Subjects
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Evolving Concepts in Endothelial Pathobiology of Pulmonary Arterial Hypertension Hypertension (IF 10.19) Pub Date : 2022-05-18 Nicholas D. Cober, M. Martin VandenBroek, Mark L. Ormiston, Duncan J. Stewart
Pulmonary arterial hypertension (PAH) is a deadly disease, characterized by increased vascular resistance, pulmonary arteriolar loss, and occlusive arterial remodeling, leading to eventual right heart failure. Evidence increasingly points to the pulmonary endothelium as a central actor in PAH. Endothelial cell apoptosis can result directly in distal lung arteriolar pruning and indirectly in the formation
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Twenty-Four-Hour Pulsatile Hemodynamics Predict Brachial Blood Pressure Response to Renal Denervation in the SPYRAL HTN-OFF MED Trial Hypertension (IF 10.19) Pub Date : 2022-05-18 Thomas Weber, Siegfried Wassertheurer, Christopher C. Mayer, Bernhard Hametner, Kathrin Danninger, Raymond R. Townsend, Felix Mahfoud, Kazuomi Kario, Martin Fahy, Vanessa DeBruin, Nicole Peterson, Manuela Negoita, Michael A. Weber, David E. Kandzari, Roland E. Schmieder, Konstantinos P. Tsioufis, Ronald K. Binder, Michael Böhm
Background:Renal denervation (RDN) lowers blood pressure (BP), but BP response is variable in individual patients. We investigated whether measures of pulsatile hemodynamics, obtained during 24-hour ambulatory BP monitoring, predict BP drop following RDN.Methods:From the randomized, sham-controlled SPYRAL HTN-OFF MED Pivotal trial, we performed a post hoc analysis of BP waveforms from 111 RDN patients
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Global Impact of Different Blood Pressure Thresholds in 4 021 690 Participants of the May Measurement Month Initiative Hypertension (IF 10.19) Pub Date : 2022-05-17 Janis M. Nolde, Thomas Beaney, Revathy Carnagarin, Aletta E. Schutte, Neil R. Poulter, Markus P. Schlaich
Background:Influential guidelines currently define hypertension at different thresholds of blood pressure (BP). The global May Measurement Month initiative provides a unique opportunity to estimate the potential consequences of universal lowering of BP thresholds on the prevalence of hypertension based on a large, real-world, patient-level data set.Methods:The average of the second and third of 3 attended
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Inverse Association of Skin Temperature With Ambulatory Blood Pressure and the Mediation of Skin Temperature in Blood Pressure Responses to Ambient Temperature Hypertension (IF 10.19) Pub Date : 2022-05-16 Yoshiaki Tai, Kenji Obayashi, Yuki Yamagami, Keigo Saeki
BACKGROUND:The inverse association between ambient temperature and blood pressure (BP) has been investigated in the context of excess cardiovascular mortality in winter. However, the role of skin temperature (ST), which reflects our external and internal thermal environments, in BP regulation remains unclear. Therefore, we examined the association between ST and ambulatory BP and the mediation of ST
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Hypertension, Arterial Stiffness, and Diabetes: a Prospective Cohort Study Hypertension (IF 10.19) Pub Date : 2022-05-16 Xue Tian, Yingting Zuo, Shuohua Chen, Yijun Zhang, Xiaoli Zhang, Qin Xu, Shouling Wu, Anxin Wang
Background:Whether the combination of different blood pressure and arterial stiffness (AS) status is independently associated with diabetes has not been fully investigated so far. This study aimed at investigating the status of hypertension and AS in determining diabetes.Methods:This prospective cohort study included 11 156 participants from the Kailuan study. AS was measured by brachial-ankle pulse
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Sex-Related Signaling of Aldosterone/Mineralocorticoid Receptor Pathway in Calcific Aortic Stenosis Hypertension (IF 10.19) Pub Date : 2022-05-12 Lara Matilla, Eva Jover, Mattie Garaikoetxea, Ernesto Martín-Nuñez, Vanessa Arrieta, Amaia García-Peña, Adela Navarro, Amaya Fernández-Celis, Alicia Gainza, Virginia Álvarez, Diego Álvarez de la Rosa, Rafael Sádaba, Frederic Jaisser, Natalia López-Andrés
BACKGROUND:There are sex differences in the pathophysiology of aortic valve (AV) calcification in patients with aortic stenosis, although the molecular and cellular mechanisms have not been elucidated. Aldosterone (Aldo) promotes proteoglycan synthesis in valve interstitial cells (VICs) from mitral valves via the mineralocorticoid receptor (MR). We investigated the influence of sex in the role of Aldo/MR
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Correction to: Occupational Physical Activity and New-Onset Hypertension: A Nationwide Cohort Study in China Hypertension (IF 10.19) Pub Date : 2022-05-11
In the article by Li et al, “Occupational Physical Activity and New-Onset Hypertension: A Nationwide Cohort Study in China,” which published in the July 2021 issue (Hypertension.2021;78:220–229. doi:/10.1161/HYPERTENSIONAHA.121.17281), a correction was needed. An error was made in transcription and did not affect the data analyses and results as presented in the article. The correction has been applied
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Correction to: Inverse Association Between Riboflavin Intake and New-Onset Hypertension: A Nationwide Cohort Study in China Hypertension (IF 10.19) Pub Date : 2022-05-11
In the article by Liu et al, “Inverse Association Between Riboflavin Intake and New-Onset Hypertension: A Nationwide Cohort Study in China,” which published in the December 2020 issue (Hypertension.2020;76:1709-1716. doi:/10.1161/HYPERTENSIONAHA.120.16211), a correction was needed. An error was made in transcription and did not affect the data analyses and results as presented in the article. The correction
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Sex Differences in Diurnal Sodium Handling During Diet-Induced Obesity in Rats Hypertension (IF 10.19) Pub Date : 2022-05-12 Reham H. Soliman, Chunhua Jin, Crystal M. Taylor, Emile Moura Coelho da Silva, David M. Pollock
Background:Emerging evidence over the past several years suggests that diurnal control of sodium excretion is sex dependent and involves the renal endothelin system. Given recent awareness of disruptions of circadian function in obesity, we determined whether diet-induced obesity impairs renal handling of an acute salt load at different times of day and whether this varies by sex and is associated
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Performance of a Multianalyte ‘Rule-Out’ Assay in Pregnant Individuals With Suspected Preeclampsia Hypertension (IF 10.19) Pub Date : 2022-05-12 Maged M. Costantine, Baha Sibai, Allan T. Bombard, Mark Sarno, Holly West, David M. Haas, Alan T. Tita, Michael J. Paidas, Erin A.S. Clark, Kim Boggess, Chad Grotegut, William Grobman, Emily J Su, Irina Burd, George Saade, Martin R. Chavez, Michael J. Paglia, Audrey Merriam, Carlos Torres, Mounira Habli, Georges Macones, Tony Wen, James Bofill, Anna Palatnik, Rodney K. Edwards, Sina Haeri, Pankaj Oberoi
Background:The ability to diagnose preeclampsia clinically is suboptimal. Our objective was to validate a novel multianalyte assay and characterize its performance, when intended for use as an aid to rule-out preeclampsia.Methods:Prospective, multicenter cohort study of pregnant individuals presenting between 280/7 and 366/7 weeks’ with preeclampsia-associated signs and symptoms. Individuals not diagnosed
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The Immune System in Hypertension: a Lost Shaker of Salt 2021 Lewis K. Dahl Memorial Lecture Hypertension (IF 10.19) Pub Date : 2022-05-12 Xiaohan Lu, Steven D. Crowley
The seminal observations of Dr Lewis Dahl regarding renal mechanisms of hypertension remain highly relevant in light of more recent experiments showing that immune system dysfunction contributes to hypertension pathogenesis. Dr Dahl established that inappropriate salt retention in the kidney plays a central role via Ohm’s Law in permitting blood pressure elevation. Nevertheless, inflammatory cytokines
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Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors Hypertension (IF 10.19) Pub Date : 2022-05-10 Tao Yang, Xue Mei, Ethel Tackie-Yarboi, Millicent Tambari Akere, Jun Kyoung, Blair Mell, Ji-Youn Yeo, Xi Cheng, Jasenka Zubcevic, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Isaac T. Schiefer, Bina Joe
Background:Despite the availability of various classes of antihypertensive medications, a large proportion of hypertensive individuals remain resistant to treatments. The reason for what contributes to low efficacy of antihypertensive medications in these individuals is elusive. The knowledge that gut microbiota is involved in pathophysiology of hypertension and drug metabolism led us to hypothesize
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Carotid Intima-Media Thickness Is Associated With Obesity and Hypertension in Young People. Hypertension (IF 10.19) Pub Date : 2022-05-11 Angela K Lucas-Herald,Christian Delles
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Disintegrin and Metalloproteinases (ADAMs [A Disintegrin and Metalloproteinase] and ADAMTSs [ADAMs With a Thrombospondin Motif]) in Aortic Aneurysm Hypertension (IF 10.19) Pub Date : 2022-05-11 Tolga Kilic, Keisuke Okuno, Satoru Eguchi, Zamaneh Kassiri
Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack of an effective pharmacological treatment highlights the need for a more thorough understanding of the factors that regulate the remodeling of the aortic wall in response
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Separate and Joint Associations of Cardiorespiratory Fitness and Healthy Vascular Aging With Subclinical Atherosclerosis in Men Hypertension (IF 10.19) Pub Date : 2022-05-10 Sae Young Jae, Kyung Hyun Lee, Hyun Jeong Kim, Setor K. Kunutsor, Kevin S. Heffernan, Rachel E. Climie, Kanokwan Bunsawat, Mira Kang
Background:Achieving healthy vascular aging (HVA) is important for decelerating age-related cardiovascular disease risk. We evaluated the interplay between HVA, cardiorespiratory fitness (CRF), and subclinical atherosclerosis.Methods:We analyzed data on 3722 men who underwent cardiopulmonary exercise testing in a health examination program. HVA was defined as blood pressure <140/90 mm Hg without hypertension
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Differences in Regulation of Cortisol Secretion Contribute to Left Ventricular Abnormalities in Patients With Essential Hypertension Hypertension (IF 10.19) Pub Date : 2022-05-10 Gabriele Brosolo, Cristiana Catena, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicolas D. Verheyen, Leonardo A. Sechi
Background:Left ventricular (LV) abnormalities were reported in patients with overt and subclinical Cushing syndrome. The aim of this study was to investigate the relationships of daily plasma cortisol profile and cortisol response to an overnight suppression test with cardiac changes in patients with hypertension.Methods:In a cross-sectional study, we included 136 nondiabetic, patients with essential
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Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide Hypertension (IF 10.19) Pub Date : 2022-05-09 Takeshi Tokudome, Kentaro Otani, Yuanjie Mao, Lars Jørn Jensen, Yuji Arai, Takahiro Miyazaki, Takashi Sonobe, James T. Pearson, Tsukasa Osaki, Naoto Minamino, Junji Ishida, Akiyoshi Fukamizu, Hayato Kawakami, Daisuke Onozuka, Kunihiro Nishimura, Mikiya Miyazato, Hirohito Nishimura
Background:ANP (atrial natriuretic peptide), acting through NPR1 (natriuretic peptide receptor 1), provokes hypotension. Such hypotension is thought to be due to ANP inducing vasodilation via NPR1 in the vasculature; however, the underlying mechanism remains unclear. Here, we investigated the mechanisms of acute and chronic blood pressure regulation by ANP.Methods and Results:Immunohistochemical analysis
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Chronic Hypoxia in Ovine Pregnancy Recapitulates Physiological and Molecular Markers of Preeclampsia in the Mother, Placenta, and Offspring Hypertension (IF 10.19) Pub Date : 2022-05-09 Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tessa A. Garrud, Peter F.B. Wooding, Caroline J. Shaw, Qiang Lyu, Lin Zhang, Jin Ma, Tereza Cindrova-Davies, Hong Wa Yung, Graham J. Burton, Dino A. Giussani
Background:Preeclampsia continues to be a prevalent pregnancy complication and underlying mechanisms remain controversial. A common feature of preeclampsia is utero-placenta hypoxia. In contrast to the impact of hypoxia on the placenta and fetus, comparatively little is known about the maternal physiology.Methods:We adopted an integrative approach to investigate the inter-relationship between chronic
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Midgestation Leptin Infusion Induces Characteristics of Clinical Preeclampsia in Mice, Which Is Ablated by Endothelial Mineralocorticoid Receptor Deletion Hypertension (IF 10.19) Pub Date : 2022-05-05 Jessica L. Faulkner, Derrian Wright, Galina Antonova, Iris Z. Jaffe, Simone Kennard, Eric J. Belin de Chantemèle
Background:Patients with preeclampsia demonstrate increases in placental leptin production in midgestation, and an associated increase in late gestation plasma leptin levels. The consequences of mid-late gestation increases in leptin production in pregnancy is unknown. Our previous work indicates that leptin infusion induces endothelial dysfunction in nonpregnant female mice via leptin-mediated aldosterone
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Epithelial Sodium Channel δ Subunit Is Expressed in Human Arteries and Has Potential Association With Hypertension Hypertension (IF 10.19) Pub Date : 2022-05-05 Puja Paudel, Isabelle van Hout, Richard W. Bunton, Dominic J. Parry, Sean Coffey, Fiona J. McDonald, Martin Fronius
Background:Elevated expression and increased activity of vascular epithelial sodium channel (ENaC) can result in vascular dysfunction in small animal models. However, there is limited or no knowledge on expression and function of ENaC channels in human vasculature. Hence, this study explored the expression and function of ENaC in human arteries and their association with hypertension.Methods:Human
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Abnormal Cyclic Nucleotide Signaling at the Outer Mitochondrial Membrane In Sympathetic Neurons During the Early Stages of Hypertension Hypertension (IF 10.19) Pub Date : 2022-05-04 Dan Li, Kun Liu, Harvey Davis, Calum Robertson, Oliver C. Neely, Adib Tarafdar, Ni Li, Konstantinos Lefkimmiatis, Manuela Zaccolo, David J. Paterson
Background:Disruption of cyclic nucleotide signaling in sympathetic postganglionic neurons contributes to impaired intracellular calcium handling (Ca2+) and the development of dysautonomia during the early stages of hypertension, although how this occurs is poorly understood. Emerging evidence supports the uncoupling of signalosomes in distinct cellular compartments involving cyclic nucleotide–sensitive
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Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone Hypertension (IF 10.19) Pub Date : 2022-05-04 Yujiro Maeoka, Xiao-Tong Su, Wen-Hui Wang, Xin-Peng Duan, Avika Sharma, Na Li, Olivier Staub, James A. McCormick, David H. Ellison
Background:MR (mineralocorticoid receptor) antagonists are recommended for patients with resistant hypertension even when circulating aldosterone levels are not high. Although aldosterone activates MR to increase epithelial sodium channel (ENaC) activity, glucocorticoids also activate MR but are metabolized by 11βHSD2 (11β-hydroxysteroid dehydrogenase type 2). 11βHSD2 is expressed at increasing levels
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Role of Antihypertensive Treatment and Blood Pressure Control in the Occurrence of Adverse Pregnancy Outcomes: a Population-Based Study of Linked Electronic Health Records Hypertension (IF 10.19) Pub Date : 2022-05-03 Sukainah Al Khalaf, Ali S. Khashan, Lucy C. Chappell, Éilis J. O’Reilly, Fergus P. McCarthy
Background:Chronic hypertension (CH) adversely impacts pregnancy. It remains unclear whether antihypertensive treatment alters these risks. We examined the role of antihypertensive treatment in the association between CH and adverse pregnancy outcomes.Methods:Electronic health records from the UK Caliber and Clinical Practice Research Datalink were used to define a cohort of women delivering between
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Association Between Hypertension and Incident Infective Endocarditis Hypertension (IF 10.19) Pub Date : 2022-05-03 Gyu Bae Lee, Koh Eun Shin, Kyungdo Han, Ho-Sung Son, Jae-Seung Jung, Yang-Hyun Kim, Hee-Jung Kim
Background:This study aimed to evaluate the association of hypertension with incident infective endocarditis (IE) by investigating the incidence of IE according to blood pressure levels using the National Health Insurance Service database.Methods:The data of 4 080 331 individuals linked to the health screening database in 2009 were retrieved (males, 55.08%; mean age, 47.12±14.13 years). From 2009 to
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Day to Day Blood Pressure Variability Associated With Cerebral Arterial Dilation and White Matter Hyperintensity Hypertension (IF 10.19) Pub Date : 2022-05-03 Boyu Zhang, Yajing Huo, Zidong Yang, Huihui Lv, Yilin Wang, Jianfeng Feng, Yan Han, He Wang
Background:Previous studies suggested blood pressure variability (BPV) might help reveal interactions between blood pressure fluctuation and white matter lesions, and the impact of elevated BPV on white matter hyperintensity (WMH) or cerebral arterial dilation is unclear.Methods:This retrospective observational study involved 2634 stroke-free individuals (68.6±11.1 years, 50.3% female), who underwent
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Calcium Sensing Receptor Variants Increase Pulmonary Hypertension Susceptibility Hypertension (IF 10.19) Pub Date : 2022-04-28 Bingxun Liu, Yun-Peng Wei, Xiaohang Fan, Xiaoyi Hu, Zeshuai Chen, Xiaoyuan Liu, Yan Xu, Lu Wang, Tao Wang, Matthieu Ruiz, Jocelyn Dupuis, Ping Yuan, Jinming Liu, Songling Huang, Liping Zhu, Zhi-Cheng Jing, Qinghua Hu
Background:Pulmonary arterial hypertension is an incurable disease, in which the extracellular CaSR (calcium sensing receptor) is mechanistically important. This study was aimed to genetically link the CaSR gene and function to the disease severity.Methods:Sanger sequencing, Sugen/hypoxia pulmonary arterial hypertension rat model, CaSR mutated rat, transcriptional reporter assay and measurement of
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DPP4 Promotes Human Endothelial Cell Senescence and Dysfunction via the PAR2–COX-2–TP Axis and NLRP3 Inflammasome Activation Hypertension (IF 10.19) Pub Date : 2022-04-28 Inés Valencia, Susana Vallejo, Pilar Dongil, Alejandra Romero, Álvaro San Hipólito-Luengo, Licia Shamoon, María Posada, Damián García-Olmo, Raffaelle Carraro, Jorge D. Erusalimsky, Tania Romacho, Concepción Peiró, Carlos F. Sánchez-Ferrer
Background:Abnormal accumulation of senescent cells in the vessel wall leads to a compromised vascular function contributing to vascular aging. Soluble DPP4 (dipeptidyl peptidase 4; sDPP4) secretion from visceral adipose tissue is enhanced in obesity, now considered a progeric condition. sDPP4 triggers vascular deleterious effects, albeit its contribution to vascular aging is unknown. We aimed to explore