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Association Between Brain Structure and Alcohol Use Behaviors in Adults: A Mendelian Randomization and Multiomics Study. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-10 Lucas A Mavromatis,Daniel B Rosoff,Renata B Cupertino,Hugh Garavan,Scott Mackey,Falk W Lohoff
Importance Past studies have identified associations between brain macrostructure and alcohol use behaviors. However, identifying directional associations between these phenotypes is difficult due to the limitations of observational studies. Objective To use mendelian randomization (MR) to identify directional associations between brain structure and alcohol use and elucidate the transcriptomic and
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Exploring Links Between Psychosis and Frontotemporal Dementia Using Multimodal Machine Learning: Dementia Praecox Revisited. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-03 Nikolaos Koutsouleris,Christos Pantelis,Dennis Velakoulis,Philip McGuire,Dominic B Dwyer,Maria-Fernanda Urquijo-Castro,Riya Paul,Sen Dong,David Popovic,Oemer Oeztuerk,Joseph Kambeitz,Raimo K R Salokangas,Jarmo Hietala,Alessandro Bertolino,Paolo Brambilla,Rachel Upthegrove,Stephen J Wood,Rebekka Lencer,Stefan Borgwardt,Carlo Maj,Markus Nöthen,Franziska Degenhardt,Maryna Polyakova,Karsten Mueller,Arno
Importance The behavioral and cognitive symptoms of severe psychotic disorders overlap with those seen in dementia. However, shared brain alterations remain disputed, and their relevance for patients in at-risk disease stages has not been explored so far. Objective To use machine learning to compare the expression of structural magnetic resonance imaging (MRI) patterns of behavioral-variant frontotemporal
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Transcranial Direct Current Stimulation vs Sham for the Treatment of Inattention in Adults With Attention-Deficit/Hyperactivity Disorder: The TUNED Randomized Clinical Trial. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-03 Douglas Teixeira Leffa,Eugenio Horacio Grevet,Claiton Henrique Dotto Bau,Maitê Schneider,Carolina Prietto Ferrazza,Roberta Francieli da Silva,Marina Silva Miranda,Felipe Picon,Stefania Pigatto Teche,Paulo Sanches,Danton Pereira,Katya Rubia,André Russowsky Brunoni,Joan A Camprodon,Wolnei Caumo,Luis Augusto Rohde
Importance Transcranial direct current stimulation (tDCS) may improve symptoms of inattention in adults with attention-deficit/hyperactivity disorder (ADHD). However, previous trials are characterized by small sample sizes, heterogeneous methodologies, and short treatment periods using clinic-based tDCS. Objective To determine the efficacy and safety of home-based tDCS in treating inattention symptoms
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Heritability of Psychotic Experiences in Adolescents and Interaction With Environmental Risk. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-03 Mark J Taylor,Daniel Freeman,Sebastian Lundström,Henrik Larsson,Angelica Ronald
Importance Genetic risk factors are known to play a role in the etiology of psychotic experiences in the general population. Little is known about whether these risk factors interact with environmental risks for psychotic experiences. Objective To assess etiological heterogeneity and exposure to environmental risks associated with psychotic experiences in adolescence using the twin design. Design,
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Association of Oxidative Stress-Induced Nucleic Acid Damage With Psychiatric Disorders in Adults: A Systematic Review and Meta-analysis. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-03 Anders Jorgensen,Ida Bendixen Baago,Zerlina Rygner,Martin Balslev Jorgensen,Per Kragh Andersen,Lars Vedel Kessing,Henrik Enghusen Poulsen
Importance Nucleic acid damage from oxidative stress (NA-OXS) may be a molecular mechanism driving the severely increased morbidity and mortality from somatic causes in adults with psychiatric disorders. Objective To systematically retrieve and analyze data on NA-OXS across the psychiatric disorder diagnostic spectrum. Data Sources The PubMed, Embase, and PsycINFO databases were searched from inception
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Investing in a Research Workforce With Personal Experience of Serious Mental Illness. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-03 David Kimhy,Nev Jones,Lisa Dixon
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Quantifying Deviations of Brain Structure and Function in Major Depressive Disorder Across Neuroimaging Modalities. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-27 Nils R Winter,Ramona Leenings,Jan Ernsting,Kelvin Sarink,Lukas Fisch,Daniel Emden,Julian Blanke,Janik Goltermann,Nils Opel,Carlotta Barkhau,Susanne Meinert,Katharina Dohm,Jonathan Repple,Marco Mauritz,Marius Gruber,Elisabeth J Leehr,Dominik Grotegerd,Ronny Redlich,Andreas Jansen,Igor Nenadic,Markus M Nöthen,Andreas Forstner,Marcella Rietschel,Joachim Groß,Jochen Bauer,Walter Heindel,Till Andlauer,Simon
Importance Identifying neurobiological differences between patients with major depressive disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta-analyses have raised concerns regarding the replicability and clinical relevance of brain alterations in depression. Objective To quantify the upper bounds of univariate effect sizes, estimated
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The Search for Clinically Useful Neuroimaging Markers of Depression-A Worthwhile Pursuit or a Futile Quest? JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-27 Lianne Schmaal
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Association of Everyday Discrimination With Depressive Symptoms and Suicidal Ideation During the COVID-19 Pandemic in the All of Us Research Program. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-27 Younga H Lee,Zhaowen Liu,Daniel Fatori,Joshua R Bauermeister,Rebecca A Luh,Cheryl R Clark,Sarah Bauermeister,André R Brunoni,Jordan W Smoller
Importance The COVID-19 pandemic has coincided with an increase in depressive symptoms as well as a growing awareness of health inequities and structural racism in the United States. Objective To examine the association of mental health with everyday discrimination during the pandemic in a large and diverse cohort of the All of Us Research Program. Design, Setting, and Participants Using repeated assessments
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Neuropsychoimaging Measures as Alternatives to Drug Use Outcomes in Clinical Trials for Addiction. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-27 Rita Z Goldstein
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Cerebrovascular Disease and Sleep-Disordered Breathing Need to Be Accounted for in Cognitive Impairment Following COVID-19-Reply. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-20 Vardan Nersesjan,Daniel Kondziella,Michael E Benros
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Cerebrovascular Disease and Sleep-Disordered Breathing Need to Be Accounted for in Cognitive Impairment Following COVID-19. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-20 George D Vavougios,Vasileios Stavrou,Konstantinos I Gourgoulianis
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Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants: Exposome-Wide Analysis and Mendelian Randomization Analysis. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-20 Bochao Danae Lin,Lotta-Katrin Pries,Halil Suat Sarac,Jim van Os,Bart P F Rutten,Jurjen Luykx,Sinan Guloksuz
Importance Although hypothesis-driven research has identified several factors associated with psychosis, this one-exposure-to-one-outcome approach fails to embrace the multiplicity of exposures. Systematic approaches, similar to agnostic genome-wide analyses, are needed to identify genuine signals. Objective To systematically investigate nongenetic correlates of psychotic experiences through data-driven
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Methadone-Involved Overdose Deaths in the US Before and After Federal Policy Changes Expanding Take-Home Methadone Doses From Opioid Treatment Programs. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-13 Christopher M Jones,Wilson M Compton,Beth Han,Grant Baldwin,Nora D Volkow
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Transdisciplinary Science and Research Training in Psychiatry: A Robust Approach to Innovation. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-13 Charles F Reynolds,Myrna M Weissman
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Complex Interaction of Lithium With Kidney and Bone Health-Reply. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-13 Ole Köhler-Forsberg,Christopher Rohde,Søren Dinesen Østergaard
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Complex Interaction of Lithium With Kidney and Bone Health. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-13 Jonathan Houle,Lorne Schweitzer,Kyle T Greenway
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Sex and Drug Overdose Mortality Trends, 1999-2020-Reply. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Joseph Friedman,Helena Hansen
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Balovaptan vs Placebo for Social Communication in Childhood Autism Spectrum Disorder: A Randomized Clinical Trial. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Eric Hollander,Suma Jacob,Roger Jou,Nora McNamara,Linmarie Sikich,Russell Tobe,Janice Smith,Kevin Sanders,Lisa Squassante,Lorraine Murtagh,Teresa Gleissl,Christoph Wandel,Jeremy Veenstra-VanderWeele
Importance There are no approved medications for the core symptoms of autism spectrum disorder (ASD), socialization and communication difficulties. Objective To evaluate the efficacy and safety of balovaptan, an oral selective vasopressin 1a receptor antagonist, compared with placebo in children and adolescents with ASD. Design, Setting, and Participants The aV1ation study was a randomized, double-blind
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Associations Between Pregnancy-Related Predisposing Factors for Offspring Neurodevelopmental Conditions and Parental Genetic Liability to Attention-Deficit/Hyperactivity Disorder, Autism, and Schizophrenia: The Norwegian Mother, Father and Child Cohort Study (MoBa). JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Alexandra Havdahl,Robyn E Wootton,Beate Leppert,Lucy Riglin,Helga Ask,Martin Tesli,Ragna Bugge Askeland,Laurie J Hannigan,Elizabeth Corfield,Anne-Siri Øyen,Ole A Andreassen,Kate Tilling,George Davey Smith,Anita Thapar,Ted Reichborn-Kjennerud,Evie Stergiakouli
Importance Several maternal exposures during pregnancy are considered predisposing factors for offspring neurodevelopmental conditions. However, many of these exposures may be noncausal and biased by maternal genetic liability. Objective To assess whether pregnancy-related predisposing factors for offspring neurodevelopmental conditions are associated with maternal genetic liability for attention-
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Preaddiction-A Missing Concept for Treating Substance Use Disorders. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 A Thomas McLellan,George F Koob,Nora D Volkow
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Sex and Drug Overdose Mortality Trends, 1999-2020. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Rebecca Arden Harris
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An Intersectional Approach to Ethnoracial Disparities in Pathways to Care Among Individuals With Psychosis in Coordinated Specialty Care. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Els van der Ven,Nev Jones,Natalie Bareis,Jennifer M Scodes,Renald Dambreville,Hong Ngo,Chackupurackal M Mathai,Iruma Bello,Gonzalo Martínez-Alés,Franco Mascayano,Rufina J Lee,Wim Veling,Deidre M Anglin,Roberto Lewis-Fernandez,Ezra S Susser,Michael T Compton,Lisa B Dixon,Melanie M Wall
Importance Intersecting factors of social position including ethnoracial background may provide meaningful ways to understand disparities in pathways to care for people with a first episode of psychosis. Objective To examine differences in pathways to care by ethnoracial groups and by empirically derived clusters combining multiple factors of social and clinical context in an ethnoracially diverse
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Brain Wellness "Spas"-Anticipating the Off-label Promotion of Psychedelics. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Anna Wexler,Dominic Sisti
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Convergence and Divergence of Rare Genetic Disorders on Brain Phenotypes: A Review. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Armin Raznahan,Hyejung Won,David C Glahn,Sébastien Jacquemont
Importance Rare genetic disorders modulating gene expression-as exemplified by gene dosage disorders (GDDs)-represent a collectively common set of high-risk factors for neuropsychiatric illness. Research on GDDs is rapidly expanding because these variants have high effect sizes and a known genetic basis. Moreover, the prevalence of recurrent GDDs (encompassing aneuploidies and certain copy number variations)
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Bridging Knowledge Gaps in the Diagnosis and Management of Neuropsychiatric Sequelae of COVID-19. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Jennifer A Frontera,Naomi M Simon
Importance Neuropsychiatric symptoms have been reported as a prominent feature of postacute sequelae of COVID-19 (PASC), with common symptoms that include cognitive impairment, sleep difficulties, depression, posttraumatic stress, and substance use disorders. A primary challenge of parsing PASC epidemiology and pathophysiology is the lack of a standard definition of the syndrome, and little is known
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Assessment of Noninvasive Brain Stimulation Interventions for Negative Symptoms of Schizophrenia: A Systematic Review and Network Meta-analysis. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Ping-Tao Tseng,Bing-Syuan Zeng,Chao-Ming Hung,Chih-Sung Liang,Brendon Stubbs,Andre F Carvalho,Andre R Brunoni,Kuan-Pin Su,Yu-Kang Tu,Yi-Cheng Wu,Tien-Yu Chen,Dian-Jeng Li,Pao-Yen Lin,Chih-Wei Hsu,Yen-Wen Chen,Mein-Woei Suen,Kazumi Satogami,Shun Takahashi,Ching-Kuan Wu,Wei-Cheng Yang,Yow-Ling Shiue,Tiao-Lai Huang,Cheng-Ta Li
Importance Negative symptoms have a detrimental impact on functional outcomes and quality of life in people with schizophrenia, and few therapeutic options are considered effective for this symptomatic dimension. Studies have suggested that noninvasive brain stimulation (NIBS) interventions may be effective in treating negative symptoms. However, the comparative efficacy of different NIBS protocols
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Implementation Strategies Used and Reported in Brief Suicide Prevention Intervention Studies. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Brittany N Rudd,Molly Davis,Stephanie Doupnik,Catalina Ordorica,Steven C Marcus,Rinad S Beidas
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Mental Health Treatment Gap-The Implementation Problem as a Research Problem. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Emma E McGinty,Matthew D Eisenberg
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Combination Antidepressant Therapy vs Monotherapy-Further Considerations-Reply. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Jonathan Henssler,Tom Bschor,Christopher Baethge
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Combination Antidepressant Therapy vs Monotherapy-Further Considerations. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Philip J Cowen
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Combination Antidepressant Therapy vs Monotherapy-Further Considerations. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Klaus Munkholm,Asger Sand Paludan-Müller
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Combination Antidepressant Therapy vs Monotherapy-Further Considerations. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Qi Wang,Liang Yao,Yaolong Chen
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Mismatch Negativity in Response to Auditory Deviance and Risk for Future Psychosis in Youth at Clinical High Risk for Psychosis. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Holly K Hamilton,Brian J Roach,Peter M Bachman,Aysenil Belger,Ricardo E Carrión,Erica Duncan,Jason K Johannesen,Gregory A Light,Margaret A Niznikiewicz,Jean Addington,Carrie E Bearden,Kristin S Cadenhead,Barbara A Cornblatt,Thomas H McGlashan,Diana O Perkins,Ming T Tsuang,Elaine F Walker,Scott W Woods,Tyrone D Cannon,Daniel H Mathalon
Importance Although clinical criteria for identifying youth at risk for psychosis have been validated, they are not sufficiently accurate for predicting outcomes to inform major treatment decisions. The identification of biomarkers may improve outcome prediction among individuals at clinical high risk for psychosis (CHR-P). Objective To examine whether mismatch negativity (MMN) event-related potential
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Gender Disparity in Cognitive Load and Emotional Labor-Threats to Women Physician Burnout. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Ashwini Nadkarni,Jhilam Biswas
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Effect of Psychiatric Advance Directives Facilitated by Peer Workers on Compulsory Admission Among People With Mental Illness: A Randomized Clinical Trial. JAMA Psychiatry (IF 25.911) Pub Date : 2022-08-01 Aurélie Tinland,Sandrine Loubière,Frederic Mougeot,Emmanuelle Jouet,Magali Pontier,Karine Baumstarck,Anderson Loundou,Nicolas Franck,Christophe Lançon,Pascal Auquier,
Importance Reducing the use of coercion in mental health care is crucial from a human rights and public health perspective. Psychiatric advance directives (PADs) are promising tools that may reduce compulsory admissions. Assessments of PADs have included facilitation by health care agents but not facilitation by peer workers. Objective To determine the efficacy of PADs facilitated by peer workers (PW-PAD)
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Association of Drug Cues and Craving With Drug Use and Relapse: A Systematic Review and Meta-analysis. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Nilofar Vafaie,Hedy Kober
Importance Craving, which is a strong desire for drugs, is a new DSM-5 diagnostic criterion for substance use disorders (SUDs), which are the most prevalent, costly, and deadly forms of psychopathology. Despite decades of research, the roles of drug cues and craving in drug use and relapse remain controversial. Objective To assess whether 4 types of drug cue and craving indicators, including cue exposure
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Comorbidity and Coaggregation of Major Depressive Disorder and Bipolar Disorder and Cannabis Use Disorder in a Controlled Family Study. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Courtney R Quick,Kevin P Conway,Joel Swendsen,Emma K Stapp,Lihong Cui,Kathleen R Merikangas
Importance Cannabis use disorder (CUD) is increasing in the US. Clarification of the potential mechanisms underlying the comorbidity between mood disorders and CUD may help prevent CUD. Objective To examine co-occurrence and familial aggregation of CUD and mood disorder subtypes. Design, Setting, and Participants In this cross-sectional, community-based study in the Washington, DC, metropolitan area
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Prevalence and Correlates of Suicide and Nonsuicidal Self-injury in Children: A Systematic Review and Meta-analysis. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Richard T Liu,Rachel F L Walsh,Ana E Sheehan,Shayna M Cheek,Christina M Sanzari
Importance Considerably less is known about self-injurious thoughts and behaviors (SITBs) in preadolescence than older age groups, owing partly to the common view that young children are incapable of suicidal thoughts. Yet, preadolescent suicide has increased in recent years and is now the fifth leading cause of death in this age group, leading the National Institute of Mental Health to identify it
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Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Dominic B Dwyer,Madalina-Octavia Buciuman,Anne Ruef,Joseph Kambeitz,Mark Sen Dong,Caedyn Stinson,Lana Kambeitz-Ilankovic,Franziska Degenhardt,Rachele Sanfelici,Linda A Antonucci,Paris Alexandros Lalousis,Julian Wenzel,Maria Fernanda Urquijo-Castro,David Popovic,Oemer Faruk Oeztuerk,Shalaila S Haas,Johanna Weiske,Daniel Hauke,Susanne Neufang,Christian Schmidt-Kraepelin,Stephan Ruhrmann,Nora Penzel,Theresa
Importance Approaches are needed to stratify individuals in early psychosis stages beyond positive symptom severity to investigate specificity related to affective and normative variation and to validate solutions with premorbid, longitudinal, and genetic risk measures. Objective To use machine learning techniques to cluster, compare, and combine subgroup solutions using clinical and brain structural
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Association of Psychiatric Services Referral and Attendance Following Treatment for Deliberate Self-harm With Prospective Mortality in Norwegian Patients. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Ping Qin,Barbara Stanley,Ingrid Melle,Lars Mehlum
Importance Psychiatric care following somatic treatment for deliberate self-harm (DSH) is pivotal in patients' lives both in the short and long term, but evidence to guide such care is limited. Objective To examine follow-up psychiatric care for patients treated for DSH (ie, intentional self-injury or self-poisoning, irrespective of motivation) at hospital emergency departments and to assess the association
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Complex Persistent Benzodiazepine Dependence-When Benzodiazepine Deprescribing Goes Awry. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Linda Peng,Thomas W Meeks,Christopher K Blazes
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The Course of General Cognitive Ability in Individuals With Psychotic Disorders. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Katherine Jonas,Wenxuan Lian,Jennifer Callahan,Camilo J Ruggero,Sean Clouston,Avraham Reichenberg,Gabrielle A Carlson,Evelyn J Bromet,Roman Kotov
Importance Schizophrenia is associated with major cognitive deficits and has been conceptualized as both a neurodevelopmental and a neurodegenerative disorder. However, when deficits develop and how they change over the course of illness is uncertain. Objective To trace cognition from elementary school to old age to test neurodevelopmental and neurodegenerative theories of psychotic disorders. Design
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Neuropsychiatric Ramifications of Severe COVID-19 and Other Severe Acute Respiratory Infections. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Ashley Kieran Clift,Tom Alan Ranger,Martina Patone,Carol A C Coupland,Robert Hatch,Karen Thomas,Julia Hippisley-Cox,Peter Watkinson
Importance Individuals surviving severe COVID-19 may be at increased risk of neuropsychiatric sequelae. Robust assessment of these risks may help improve clinical understanding of the post-COVID syndrome, aid clinical care during the ongoing pandemic, and inform postpandemic planning. Objective To quantify the risks of new-onset neuropsychiatric conditions and new neuropsychiatric medication prescriptions
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Suicide Attempt and Risk of Substance Use Disorders Among Female Youths. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Nathalie Auger,Nicholas Chadi,Aimina Ayoub,Émilie Brousseau,Nancy Low
Importance Suicide attempts are prevalent among female youths, yet little is known about the subsequent development of substance use disorders. Objective To assess the association between suicide attempts among females before 20 years of age and future risk of substance use disorders. Design, Setting, and Participants In this longitudinal cohort study, females aged 8 to 19 years (hereafter referred
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Copy Number Variant Risk Scores Associated With Cognition, Psychopathology, and Brain Structure in Youths in the Philadelphia Neurodevelopmental Cohort. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Aaron Alexander-Bloch,Guillaume Huguet,Laura M Schultz,Nicholas Huffnagle,Sebastien Jacquemont,Jakob Seidlitz,Zohra Saci,Tyler M Moore,Richard A I Bethlehem,Josephine Mollon,Emma K Knowles,Armin Raznahan,Alison Merikangas,Barbara H Chaiyachati,Harshini Raman,J Eric Schmitt,Ran Barzilay,Monica E Calkins,Russel T Shinohara,Theodore D Satterthwaite,Ruben C Gur,David C Glahn,Laura Almasy,Raquel E Gur,Hakon
Importance Psychiatric and cognitive phenotypes have been associated with a range of specific, rare copy number variants (CNVs). Moreover, IQ is strongly associated with CNV risk scores that model the predicted risk of CNVs across the genome. But the utility of CNV risk scores for psychiatric phenotypes has been sparsely examined. Objective To determine how CNV risk scores, common genetic variation
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Evaluation of the Trajectory of Depression Severity With Ketamine and Esketamine Treatment in a Clinical Setting. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Sina Nikayin,Taeho Greg Rhee,Maria Elena Cunningham,Christina A de Fontnouvelle,Robert B Ostroff,Gerard Sanacora,Samuel T Wilkinson
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Associating Violence With Schizophrenia-Risks and Biases-Reply. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Daniel Whiting,John R Geddes,Seena Fazel
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Associating Violence With Schizophrenia-Risks and Biases. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Paolo Fusar-Poli,Charlene Sunkel,Vikram Patel
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An Atlas of Genetic Correlations and Genetically Informed Associations Linking Psychiatric and Immune-Related Phenotypes. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Daniel S Tylee,Yu Kyung Lee,Frank R Wendt,Gita A Pathak,Daniel F Levey,Flavio De Angelis,Joel Gelernter,Renato Polimanti
Importance Certain psychiatric and immune-related disorders are reciprocal risk factors. However, the nature of these associations is unclear. Objective To characterize the pleiotropy between psychiatric and immune-related traits, as well as risk factors of hypothesized relevance. Design, Setting, and Participants This genetic association study was conducted from July 10, 2020, to January 15, 2022
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Associating Violence With Schizophrenia-Risks and Biases. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Chih-Wei Hsu,Ping-Tao Tseng,Yu-Kang Tu
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Physician-Assisted Death for Patients With Dementia. JAMA Psychiatry (IF 25.911) Pub Date : 2022-07-01 Sisco M P van Veen,Guy A M Widdershoven,Aartjan T F Beekman
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Cortical Thickness Abnormalities at Different Stages of the Illness Course in Schizophrenia: A Systematic Review and Meta-analysis. JAMA Psychiatry (IF 25.911) Pub Date : 2022-06-01 Youjin Zhao,Qian Zhang,Chandan Shah,Qian Li,John A Sweeney,Fei Li,Qiyong Gong
Importance Questions of whether and how cortical thickness (CTh) alterations differ over the course of schizophrenia (SCZ) have yet to be resolved. Objective To characterize CTh alterations across illness stages in SCZ. Data Sources PubMed, Embase, Web of Science, and Science Direct were screened for CTh studies published before June 15, 2021. Study Selection Original studies comparing whole-brain
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Suicide Deaths Among Women in California Living With Handgun Owners vs Those Living With Other Adults in Handgun-Free Homes, 2004-2016. JAMA Psychiatry (IF 25.911) Pub Date : 2022-06-01 Matthew Miller,Yifan Zhang,Lea Prince,Sonja A Swanson,Garen J Wintemute,Erin E Holsinger,David M Studdert
Importance Little is known about the extent to which secondhand exposure to household firearms is associated with risk of suicide in adults who do not own guns, most of whom are women. Objective To evaluate changes in risk of suicide among women living in gun-free households after one of their cohabitants became a handgun owner. Design, Setting, and Participants This cohort study observed participants
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Toward Risk-Benefit Assessments in Psychedelic- and MDMA-Assisted Therapies. JAMA Psychiatry (IF 25.911) Pub Date : 2022-06-01 Mazdak M Bradberry,Natalie Gukasyan,Charles L Raison
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Association of Social Determinants of Health and Vaccinations With Child Mental Health During the COVID-19 Pandemic in the US. JAMA Psychiatry (IF 25.911) Pub Date : 2022-06-01 Yunyu Xiao,Paul Siu-Fai Yip,Jyotishman Pathak,J John Mann
Importance The COVID-19 pandemic disproportionately affected mental health in socioeconomically disadvantaged children in the US. However, little is known about the relationship of preexisting and time-varying social determinants of health (SDoH) at individual and structural levels, vaccination eligibility/rates, and the racial and ethnic differences to trajectories of child mental health during the
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Effect of Culturally Tailored, Internet-Delivered Cognitive Behavioral Therapy for Insomnia in Black Women: A Randomized Clinical Trial. JAMA Psychiatry (IF 25.911) Pub Date : 2022-06-01 Eric S Zhou,Lee M Ritterband,Traci N Bethea,Yvonne P Robles,Timothy C Heeren,Lynn Rosenberg
Importance Black women are at risk for insomnia disorder. Despite interest in addressing sleep health disparities, there is limited research investigating the efficacy of criterion-standard treatment (cognitive behavioral therapy for insomnia [CBT-I]) among this racial minority population. Objective To compare the efficacy of a standard version of an internet-delivered CBT-I program, a culturally tailored
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Efficacy of Augmentation of Cognitive Behavioral Therapy With Transcranial Direct Current Stimulation for Depression: A Randomized Clinical Trial. JAMA Psychiatry (IF 25.911) Pub Date : 2022-06-01 Sabine Aust,Eva-Lotta Brakemeier,Jan Spies,Ana Lucia Herrera-Melendez,Tim Kaiser,Andreas Fallgatter,Christian Plewnia,Sarah V Mayer,Esther Dechantsreiter,Gerrit Burkhardt,Maria Strauß,Nicole Mauche,Claus Normann,Lukas Frase,Michael Deuschle,Andreas Böhringer,Frank Padberg,Malek Bajbouj
Importance Major depressive disorder (MDD) affects approximately 10% of the population globally. Approximately 20% to 30% of patients with MDD do not sufficiently respond to standard treatment. Therefore, there is a need to develop more effective treatment strategies. Objective To investigate whether the efficacy of cognitive behavioral therapy (CBT) for the treatment of MDD can be enhanced by concurrent
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Cerebrospinal Fluid Biomarkers in Patients With Unipolar Depression Compared With Healthy Control Individuals: A Systematic Review and Meta-analysis. JAMA Psychiatry (IF 25.911) Pub Date : 2022-06-01 Ina Viktoria Mousten,Nina Vindegaard Sørensen,Rune Haubo B Christensen,Michael Eriksen Benros
Importance Depression has been associated with alterations in neurotransmitters, hormones, and inflammatory and neurodegenerative biomarkers, and biomarkers quantified in the cerebrospinal fluid (CSF) are more likely to reflect ongoing biochemical changes within the brain. However, a comprehensive overview of CSF biomarkers is lacking and could contribute to the pathophysiological understanding of
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Tempering Optimism Concerning the Recent Decline in US Suicide Deaths. JAMA Psychiatry (IF 25.911) Pub Date : 2022-06-01 Mark Olfson,Rajeev Ramchand,Michael Schoenbaum