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Examining the Impact of the Human Microbiome in the Perioperative Setting. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-06 Huang Huang,Julie Mani,Thomas R Vetter,Tong Joo Gan
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Cancer Epidemiology and Global Implications for Anesthesiology and Perioperative Medicine. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-06 Svs Deo,Manish K Gaur
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Can Allogeneic Transfusions Harm Patients Undergoing Cancer Surgery? Anesth. Analg. (IF 4.6) Pub Date : 2025-02-06 Neil Blumberg,Shannon L Farmer
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A New Method for Comprehensive Analysis of Benzodiazepine, Opioid, and Propofol Interactions and Dose Selection Rationales in Gastrointestinal Endoscopy Sedation. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-05 Jing-Yang Liou,Hsin-Yi Wang,I-Ting Kuo,Mei-Yung Tsou,Weng-Kuei Chang,Chien-Kun Ting
BACKGROUND The aim of this study was to explore a new method for determining optimal dosing regimens for combinations of propofol, midazolam, and an opioid to achieve rapid on- and off-set of deep sedation. METHODS We simulated 16 published dosing regimens using a well-validated pharmacodynamic model. The study was divided into 2 parts. First, the regimen that best provided deep sedation and rapid
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Epidemiological Investigation of Unplanned Intensive Care Unit Admissions From the Operating Room After Elective Surgery: A Nationwide Observational Study in Japan. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-05 Miki Omoto,Yoshitaka Aoki,Mikio Nakajima,Tadayoshi Kurita,Richard H Kaszynski,Hiromi Kato,Soichiro Mimuro,Hiroshi Igarashi,Yoshiki Nakajima
BACKGROUND Over 75% of surgeries worldwide are elective and unplanned ICU admissions after these surgeries pose a major-albeit rare-challenge. However, few epidemiological studies have focused on patients requiring unplanned ICU admission directly from the operating room after elective surgeries are lacking. This study uses the Japanese Intensive Care Patient Database (JIPAD) to describe unplanned
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Opioid Preconditioning in Heart Failure: New Frontier or Old Dog? Anesth. Analg. (IF 4.6) Pub Date : 2025-02-05 Detlef Obal,Yu Liu
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Effect of Low-Dose Ketamine Infusion in the Intensive Care Unit on Postoperative Opioid Consumption and Traumatic Memories After Hospital Discharge: A Randomized Controlled Trial. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-05 Nuanprae Kitisin,Nattaya Raykateeraroj,Nattachai Hemtanon,Piyawuth Kamtip,Napat Thikom,Omid Azimaraghi,Annop Piriyapatsom,Onuma Chaiwat,Matthias Eikermann,Karuna Wongtangman
BACKGROUND Low-dose ketamine may have an opioid-sparing effect in critically ill patients but may also predispose them to traumatic memories. We evaluated the effects of low-dose ketamine infusion in the intensive care unit (ICU) on fentanyl consumption and traumatic memories after hospital discharge. METHODS This randomized, double-blind, controlled trial was conducted at a university-based surgical
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Minimum Estimated Time to Wakeup-A Novel Parameter to Determine Wakeup Time After Total Intravenous or Volatile Anesthesia? Anesth. Analg. (IF 4.6) Pub Date : 2025-02-05 Thomas M Hemmerling
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The Tip of the Melting Iceberg: A Comment on Medical Education. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-05 Brant M Wagener,Mitchell H Tsai,Dan E Berkowitz
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Association of Intraoperative Occult Hypoxemia With 30-Day and 1-Year Mortality. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-04 Blaine Stannard,Garrett W Burnett,David B Wax,Natalia N Egorova,Yuxia Ouyang,Chantal Pyram-Vincent,Samuel DeMaria,Matthew A Levin
BACKGROUND Despite the widespread use of pulse oximetry for intraoperative estimation of arterial oxygen saturation, there is growing evidence that certain patient populations may be vulnerable to inaccurate pulse oximetry measurements and that unrecognized hypoxemia is associated with end-organ damage and adverse outcomes. In this single-center retrospective cohort study, we sought to better elucidate
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Fibrinogen Replacement in Neonatal Cardiac Surgery: Methodological Challenges. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-04 Amir L Butt,Michael A Mazzeffi,Yuko Mishima,Kenichi A Tanaka
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Anesthetic Management of Parturients With Achondroplasia During Labor and Delivery: A Narrative Review. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-04 Catalina I Dumitrascu,Peace N Eneh,Audrey A Keim,Molly B Kraus,Emily E Sharpe
Achondroplasia accounts for approximately 70% of all forms of dwarfism. Cesarean delivery is often required in parturients with achondroplasia due to cephalopelvic disproportion. There is no consensus on the optimal management for cesarean delivery considering the difficulties in both general and regional anesthesia in patients with achondroplasia. The aim of this study was to explore the literature
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Examining the Impact of High-Decibel Environment on Anesthesiologists' Crisis Situation Management. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-03 Jean-François Gagné,Said Dababneh,Marie-Ève Bélanger,Mihai Georgescu,Pierre Drolet,Philippe Richebé,Rami Issa,Issam Tanoubi
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Gut Microbiota Influences Developmental Anesthetic Neurotoxicity in Neonatal Rats. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-03 Tomohiro Chaki,Yuri Horiguchi,Shunsuke Tachibana,Satoshi Sato,Tomoki Hirahata,Noriaki Nishihara,Natsumi Kii,Yusuke Yoshikawa,Kengo Hayamizu,Michiaki Yamakage
BACKGROUND Anesthetic exposure during childhood is significantly associated with impairment of neurodevelopmental outcomes; however, the causal relationship and detailed mechanism of developmental anesthetic neurotoxicity remain unclear. Gut microbiota produces various metabolites and influences the brain function and development of the host. This relationship is referred to as the gut-brain axis.
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Fibrinogen Dose Variability in Cardiac Surgery Patients Who Required Cryoprecipitate Replacement. Anesth. Analg. (IF 4.6) Pub Date : 2025-02-03 Félix R Montes,Laura Peña-Blanco,Andrea Barragán-Méndez,Angélica M Patiño,Hugo Mantilla-Gutiérrez,German Franco-Gruntorad
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Single-Injection Intrathecal Hydrophilic Opioids in Abdominal Surgery: Ready to Roll Out? Anesth. Analg. (IF 4.6) Pub Date : 2025-01-31 Choy Lewis,Ravindra Alok Gupta,Ariana Nelson,Mark Koning
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Preoperative Psychological Factors, Postoperative Pain Scores, and Development of Posttraumatic Stress Disorder Symptoms After Pediatric Anterior Cruciate Ligament Reconstruction. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-31 Kesavan Sadacharam,Kristen Uhl,Stephen Kelleher,Galit Kastner Ungar,Steven Staffa,Joseph Cravero,James Bradley,Matthew D Milewski,Brian Lau,Wallis T Muhly,
BACKGROUND Acute orthopedic injuries and subsequent surgical repair can be challenging for children and adolescents and result in posttraumatic stress reactions that can be problematic after the acute perioperative period. In a cohort of patients undergoing anterior cruciate ligament reconstruction (ACLR), we investigated the incidence and explored risk factors associated with the development of posttraumatic
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Machine Learning Modeling for American Society of Anesthesiologists Physical Status Classification Assignment in Children. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-30 Hannah Lonsdale,Susan S Eagle,Robert E Freundlich
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Perioperative Pain Management in Patients With Cancer-Related Pain: A Narrative Review. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-30 Storm V Horine,Neal Rakesh,Danielle Nadav,Amitabh Gulati
The number of cancer patients, cancer survivors, and cancer surgeries is expected to continue to grow and anesthesiologists will benefit from having a framework on how to approach treating perioperative pain in the oncologic population. This article presents general considerations for formulating a perioperative pain management plan including cancer-specific contraindications for epidurals and nerve
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Unmasking Hidden Threats: A Case of Ventilation Resistance Due to Twisted Circuit. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-29 Sumit Sachan,Ruchi Verma,Dhiraj Singh
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Regional Anesthesia and Pain Outcomes After Anterior Cruciate Ligament Reconstruction Surgery in Pediatric Patients: Society of Pediatric Anesthesia Improvement Network. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-29 Kesavan Sadacharam,Tessa Mandler,Steven J Staffa,Sophie R Pestieau,Clinton Fuller,Matthew Ellington,J William Sparks,Allison M Fernandez,
BACKGROUND Optimal perioperative pain management is unknown for adolescent patients undergoing anterior cruciate ligament reconstruction (ACLR). The study aimed to determine the association of nerve blocks with short- and long-term pain outcomes and factors influencing self-reported neurological symptoms. METHODS We performed a multisite, prospective observational study of adolescent patients undergoing
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Point of Care Ultrasound to Evaluate Lung Isolation in Children: Methodological Concerns. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-29 Divya Jain,Sabina Khanal,Sandhya Yaddanapudi
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Anatomical Variation of the Interscalene Brachial Plexus Block: Clinical Importance and Alternative Approach. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-29 Yavuz Gurkan,Ergun Mendes,Adem Halis,Rafet O Görgülü
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Pillar[6]MaxQ and Sugammadex Enhance Recovery From Rocuronium- and Vecuronium-Mediated Neuromuscular Blockade With Similar Effects in Isoflurane-Anesthetized Rats. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-28 Joseph F Cotten,Lyle Isaacs
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Patient Blood Management Program Implementation and Assessment Tool: Measuring Compliance With Guidelines and World Health Organization 2021 Policy Brief. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-28 Shannon L Farmer,Carleen Ellis,Jeffrey M Hamdorf,Darren Falconer,Kylie Symons,Claire McNally,Angie Monk,Michael F Leahy,Nolan McDonnell,Axel Hofmann
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Patients' Experiences With Opioid Tapering in Noncancer Pain: A Systematic Review and Meta-synthesis. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-28 Sophie A Young,Shania Liu,Asad E Patanwala,Justine M Naylor,Jennifer Stevens,Jonathan Penm
Tapering opioids is an effective strategy to reduce the risks associated with long-term opioid therapy. However, patients' experience with tapering can influence the success of this treatment. Understanding patients' experiences with opioid tapering will allow for patient-centered approaches to be adopted to tailor interventions to achieve safe and successful taper outcomes. This paper aims to synthesize
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Whispers in the Operating Room: Anesthesia and Oriana Fallaci. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-28 Rafael Ortega
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Dexamethasone: The Alan Turing of Surgical Site Infection in Noncardiac Surgery. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-27 Fabricio Andres Lasso Andrade
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When the Drip Stops: The Intravenous Fluid Shortage. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-27 Soobin Song,MaKayla Hoggard,Rafael Ortega
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Red Blood Cell Transfusion Is Not a Recommended Treatment of Preoperative Anemia. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-27 Thijs C D Rettig,Liselot Groenewegen,Maarten Ter Horst,Peter G Noordzij
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Preoperative Multidisciplinary Huddles for Unscheduled Cesarean Deliveries: Expanding Scope. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-27 Allan Xu,Priya Sivarajasingam,Vinod Patil
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Anesthesia Trauma Guidelines: A Systematic Review of Global Accessibility and Quality. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-24 Jakob E Gamboa,Ryan Turner,Noah LaBelle,Mario Villasenor,Ben Harnke,Gabriela Zavala,Lacey N LaGrone,Colby G Simmons
This systematic review describes the available clinical practice guidelines (CPGs) for the anesthetic management of trauma and appraises the accessibility and quality of these resources. This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search was conducted across 8 databases (MEDLINE, Embase, Web of Science, CABI Digital
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Insights and Trends in Artificial Intelligence Driven Innovations in Anesthesia: An Analysis of Global Patent Activity (2010-2024). Anesth. Analg. (IF 4.6) Pub Date : 2025-01-24 Clyde T Matava,Armaan Dosani,Martina Bordini,Jonathan Tan
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The Association of the Coronavirus Disease-2019 Pandemic With Disparities in Maternal Outcomes. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-22 Laurent G Glance,Karen E Joynt Maddox,J Christopher Glantz,Eeshwar K Chandrasekar,Ernie Shippey,Richard N Wissler,Patricia W Stone,Jingjing Shang,Anjana Kundu,Andrew W Dick
BACKGROUND In the United States, Black and Hispanic patients have substantially worse maternal outcomes than non-Hispanic White patients. The goals of this study were to evaluate the association between the coronavirus disease-2019 (COVID-19) pandemic and maternal outcomes, and whether Black and Hispanic patients were disproportionately affected by the pandemic compared to White patients. METHODS Multivariable
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Interpretation of Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Importance of Clinical Context. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-22 Sijm H Noteboom,Eline Kho,Denise P Veelo,Björn J P van der Ster,Maite M T van Haeren,Victor A Viersen,Marcella C A Müller,Henning Hermanns,Alexander P J Vlaar,Jimmy Schenk,
BACKGROUND Rotational thromboelastometry (ROTEM) is widely used for point-of-care coagulation testing to reduce blood transfusions. Accurate interpretation of ROTEM data is crucial and requires substantial training. This study investigates the inter- and intrarater reliability of ROTEM interpretation among experts and compares their interpretations with a ROTEM-guided algorithm. METHODS This study
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Compassion and Postoperative Pain Scores: Killing Pain With Kindness? Anesth. Analg. (IF 4.6) Pub Date : 2025-01-22 Alireza Danesh,Kailee N May,Aimee Pak,Amir L Butt
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Social Determinants of Health in Machine-Learning Algorithms. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-22 Nancy M Boulos,En Chang,Brittany N Burton
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Effects of Variable Ventilation on Gas Exchange in an Experimental Model of Capnoperitoneum: A Randomized Crossover Study. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-22 Álmos Schranc,Roberta Südy,John Daniels,Fabienne Fontao,Ferenc Peták,Walid Habre,Gergely Albu
BACKGROUND The rapid advancement of minimally invasive surgical techniques has made laparoscopy a preferred alternative because it reduces postoperative complications. However, inflating the peritoneum with CO2 causes a cranial shift of the diaphragm decreasing lung volume and impairing gas exchange. Additionally, CO2 absorption increases blood CO2 levels, further complicating mechanical ventilation
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Effect of Treatment With Balanced Crystalloids Versus Normal Saline on the Mortality of Critically Ill Patients With and Without Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-20 José C Diz,Pedro Luna-Rojas,Pablo Díaz-Vidal,Uxía Fernández-Vázquez,Cristina Gil-Casado,Eva Diz-Ferreira
BACKGROUND Some studies suggest that balanced solutions may improve outcomes in critical care patients. However, in patients with traumatic brain injury (TBI) existing data indicate that normal saline may be preferred. We hypothesized that mortality in critically ill patients with and without TBI would differ with the use of balanced salt solutions versus normal saline. METHODS We conducted a systematic
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Comparing General Anesthesia-Based Regimens for Endovascular Treatment of Acute Ischemic Stroke: A Systematic Review and Network Meta-Analysis. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-20 Eric Plitman,Ayman Mohammed,Wesley Rajaleelan,Rodrigo Nakatani,Marina Englesakis,Jai Shankar,Lashmi Venkatraghavan,Tumul Chowdhury
BACKGROUND Total intravenous anesthesia (TIVA)-based and volatile-based general anesthesia have different effects on cerebral hemodynamics. The current work compares these 2 regimens in acute ischemic stroke patients undergoing endovascular therapy. METHODS We conducted a systematic literature search across MEDLINE, Embase, Cochrane, CINAHL, Web of Science, and Scopus. We identified English language
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Epidural Morphine for Vaginal Delivery: Determining Benefit. Anesth. Analg. (IF 4.6) Pub Date : 2025-01-20 Fu S Xue,Dan F Wang,Xiao C Zheng
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Machine Perfusion for Liver Transplant: What Are the Challenges? Anesth. Analg. (IF 4.6) Pub Date : 2025-01-20 Bryant W Tran,Ezekiel D Egan,Duncan J McLean,Ricardo A Serrano
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In Response Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Jiayi Gong, Amy Hai Yan Chan, Kebede Beyene, Chris Frampton, Peter Jones
An abstract is unavailable.
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Persistent Opioid Use After Hospital Admission From Surgery in New Zealand: A Population-Based Study Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Yinfang Wu, Weixing Xu
An abstract is unavailable.
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An Illustrated Summary of Approaches for Ultrasound-Guided Maxillary Nerve Block Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Qian Liu, Qing Zhong, Tao Xu
An abstract is unavailable.
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Not All Blocks Are Created Equal: Navigating the Murky Waters of Pooled Data Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Andreas Sotiriou, Morgan Harold, Kariem El-Boghdadly
An abstract is unavailable.
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In Response Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Keith Howell, Patrick Tighe, Catherine C. Price, Cynthia Garvan
An abstract is unavailable.
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Preoperative Anemia and Postoperative Cognitive Function: Methodological Concerns Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Vincent M. Dieu, Tricia A. Haynes, Kenichi A. Tanaka, Amir L. Butt
An abstract is unavailable.
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Multivariable Predictive Model of Postoperative Delirium in Cardiac Surgery Patients: Proteomic and Demographic Contributions Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Maria C. B. Gonçalves, Tanvi Khera, Hasan H. Otu, Shilpa Narayanan, Simon T. Dillon, Akshay Shanker, Xuesong Gu, Yoojin Jung, Long H. Ngo, Edward R. Marcantonio, Towia A. Libermann, Balachundhar Subramaniam
ac surgery. METHODS: SomaScan analysis of 1305 proteins in the plasma from 57 older adults undergoing cardiac surgery requiring cardiopulmonary bypass was conducted to define delirium-specific protein signatures at baseline (preoperative baseline timepoint [PREOP]) and postoperative day 2 (POD2). Selected proteins were validated in 115 patients using the Enzyme-Linked Lectin Assay (ELLA) multiplex
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Association Between the Ultrasound Evaluation of Muscle Mass and Adverse Outcomes in Critically Ill Patients: A Prospective Cohort Study Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Michele Umbrello, Paolo Formenti, Alessandro Artale, Maddalena Assandri, Chiara Palandri, Silvia Ponti, Roberto Venco, Giulia Waccher, Stefano Muttini
CSA) and intensive care unit (ICU) mortality. Secondary outcomes were the determinants of RF-CSA, and the diagnostic performance of RF-CSA after adjustment for body size. METHODS: A prospective, single-center, observational cohort study was conducted in 3 ICUs (general, neuroscience, coronavirus disease-2019 [COVID-19]) of a university-affiliated hospital. Consecutive, mechanically ventilated patients
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Recognizing the Awe in Anesthesia Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Dan E. Berkowitz, D. Matthew Sherrer, Thomas R. Vetter
An abstract is unavailable.
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Overactive Glutamatergic Basal Forebrain: Compensatory or Causal Mechanism in Cognitive Disorders Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Diany Paola Calderon, Peter A. Goldstein
An abstract is unavailable.
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A Randomized Trial of Shortened Air-Q Self-Pressurizing Intubating Laryngeal Airway Versus Williams Intubating Airway for Flexible Bronchoscopic Intubation Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Claire X. Sun, Kristopher M. Schroeder, Richard E. Galgon
An abstract is unavailable.
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The Future of Artificial Intelligence Using Images and Clinical Assessment for Difficult Airway Management Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Silvia De Rosa, Elena Bignami, Valentina Bellini, Denise Battaglini
ped and validated to predict difficult airways. Despite advances in AI modeling. In this review article, we describe the advantages of using AI models. We explore how these methods could impact clinical practice. Finally, we discuss predictive modeling for difficult laryngoscopy using machine-learning and the future approach with intelligent intubation devices....
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Supraglottic Airways in Children With Predicted Difficult Airway Management: Awake or Not Awake, That Is the Question! Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Nicola Disma, Takashi Asai, Narasimhan Jagannathan
An abstract is unavailable.
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Difficult Airway Management: From the Power of Prediction to the Art of Management Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Thomas Heidegger, Jaideep J. Pandit
An abstract is unavailable.
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Combining Anatomical, Clinical, and Physiological Signs in Confirming Correct Tracheal Tube Placement: The Value in “Seeing (the Tube) Is Believing (in Its Position)” Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Kariem El-Boghdadly, Jaideep J. Pandit
An abstract is unavailable.
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Second-Generation Supraglottic Airway Devices Versus Endotracheal Intubation in Adults Undergoing Abdominopelvic Surgery: A Systematic Review and Meta-Analysis Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Clístenes Crístian de Carvalho, Ioannis Kapsokalyvas, Kariem El-Boghdadly
ive safety, efficacy, and quality of recovery in adults undergoing abdominopelvic surgery under general anesthesia. Our primary objective was to assess safety in the form of major airway complications. Secondary objectives were other safety, efficacy, and quality of recovery outcomes. METHODS: We searched 4 databases for randomized controlled trials of adult patients having abdominopelvic surgery comparing
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Pulmonary Ventilation and Aspiration in Laparoscopic and Abdominal Surgery: Can We Get Away With a Supraglottic Airway? Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Michael F. Aziz, Narasimhan Jagannathan
An abstract is unavailable.
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Supraglottic Airways: Does Safety Evolve with Design? Anesth. Analg. (IF 4.6) Pub Date : 2025-01-10 Naveen Nathan
An abstract is unavailable.