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A timeline of biomarker changes before Alzheimer’s disease Nat. Med. (IF 82.9) Pub Date : 2024-03-15
Longitudinal data from the China Cognition and Aging Study map the sequential biomarker changes that begin almost two decades before clinical onset of Alzheimer’s disease.
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Telehealth enables safe medication abortion in shifting health and legal contexts Nat. Med. (IF 82.9) Pub Date : 2024-03-15 Dana M. Johnson, Abigail R. A. Aiken, Terri-Ann Thompson
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Prolonged benefits of bariatric surgery for patients with Type 2 Diabetes Nat. Med. (IF 82.9) Pub Date : 2024-03-15
People with type 2 diabetes who underwent bariatric surgery compared to medical or lifestyle interventions had better long-term outcomes, such as greater diabetes remission and less reliance on medication.
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Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial Nat. Med. (IF 82.9) Pub Date : 2024-03-14 Marcia Scazufca, Carina Akemi Nakamura, Nadine Seward, Thiago Vinicius Nadaleto Didone, Felipe Azevedo Moretti, Marcelo Oliveira da Costa, Caio Hudson Queiroz de Souza, Gabriel Macias de Oliveira, Monica Souza dos Santos, Luara Aragoni Pereira, Mariana Mendes de Sá Martins, Pepijn van de Ven, William Hollingworth, Tim J. Peters, Ricardo Araya
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Acquired blood mutations cause acute kidney injury via dysregulated inflammation Nat. Med. (IF 82.9) Pub Date : 2024-03-13
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Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results Nat. Med. (IF 82.9) Pub Date : 2024-03-13 Stephen J. Bagley, Meghan Logun, Joseph A. Fraietta, Xin Wang, Arati S. Desai, Linda J. Bagley, Ali Nabavizadeh, Danuta Jarocha, Rene Martins, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel Leskowitz, Julie K. Jadlowsky, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, Yusha Sun, Whitney Gladney, David Barrett, MacLean P. Nasrallah, Wei-Ting
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Mpox continues to spread in Africa and threatens global health security Nat. Med. (IF 82.9) Pub Date : 2024-03-12 Kyeng Mercy, Bethelhem Tibebu, Mosoka Fallah, Nuno R. Faria, Nicaise Ndembi, Yenew Kebede Tebeje
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Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing Nat. Med. (IF 82.9) Pub Date : 2024-03-12 Nienke J. Mekkes, Minke Groot, Eric Hoekstra, Alyse de Boer, Ekaterina Dagkesamanskaia, Sander Bouwman, Sophie M. T. Wehrens, Megan K. Herbert, Dennis D. Wever, Annemieke Rozemuller, Bart J. L. Eggen, Inge Huitinga, Inge R. Holtman
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How AI-powered handheld devices are boosting disease diagnostics - from cancer to dermatology Nat. Med. (IF 82.9) Pub Date : 2024-03-12
Nature Medicine explores the latest translational and clinical research news, with FDA approval of an AI-assisted optical reader to help in the diagnosis of skin cancer.
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MEGA CRISPR rejuvenates exhausted CAR T cells Nat. Med. (IF 82.9) Pub Date : 2024-03-11
MEGA is a new CRISPR-based RNA-editing platform with the ability to enhance the fitness of CAR T cells; it may also overcome certain limitations of conventional DNA-targeting CRISPR–Cas9 systems.
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Developing a conceptual framework for the early adoption of healthcare technologies in hospitals Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Sheena Visram, Yvonne Rogers, Neil J. Sebire
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Restocking the tuberculosis drug arsenal Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Eric L. Nuermberger, Richard E. Chaisson
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Steatotic liver disease: a new name to reflect the combined role of alcohol and metabolic dysfunction Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Aleksander Krag, Mary E. Rinella
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Sex-specific genetic architecture of blood pressure Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Min-Lee Yang, Chang Xu, Trisha Gupte, Thomas J. Hoffmann, Carlos Iribarren, Xiang Zhou, Santhi K. Ganesh
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Implementation of pooled saliva tests for universal screening of cCMV infection Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Lior Merav, Noa Ofek Shlomai, Esther Oiknine-Djian, Orit Caplan, Ayala Livneh, Tal Sido, Amir Peri, Aviad Shtoyer, Eden Amir, Kerem Ben Meir, Yutti Daitch, Mila Rivkin, Esther Kripper, Irit Fogel, Hadar Horowitz, Sraya Greenberger, Mevaseret Cohen, Miriam Geal-Dor, Oren Gordon, Diana Averbuch, Zivanit Ergaz-Shaltiel, Smadar Eventov Friedman, Dana G. Wolf, Moran Yassour
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Self-care interventions for women’s health and well-being Nat. Med. (IF 82.9) Pub Date : 2024-03-07 Manjulaa Narasimhan, James R. Hargreaves, Carmen H. Logie, Quarraisha Abdool-Karim, Mandip Aujla, Jonathan Hopkins, Jane Cover, Olive Sentumbwe-Mugisa, Allan Maleche, Kate Gilmore
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Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors Nat. Med. (IF 82.9) Pub Date : 2024-03-07 Todd M. Gibson, Danielle M. Karyadi, Stephen W. Hartley, Michael A. Arnold, Amy Berrington de Gonzalez, Miriam R. Conces, Rebecca M. Howell, Vidushi Kapoor, Wendy M. Leisenring, Joseph P. Neglia, Joshua N. Sampson, Lucie M. Turcotte, Stephen J. Chanock, Gregory T. Armstrong, Lindsay M. Morton
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Locoregional delivery of IL-13Rα2-targeting CAR-T cells in recurrent high-grade glioma: a phase 1 trial Nat. Med. (IF 82.9) Pub Date : 2024-03-07 Christine E. Brown, Jonathan C. Hibbard, Darya Alizadeh, M. Suzette Blanchard, Heini M. Natri, Dongrui Wang, Julie R. Ostberg, Brenda Aguilar, Jamie R. Wagner, Jinny A. Paul, Renate Starr, Robyn A. Wong, Wuyang Chen, Noah Shulkin, Maryam Aftabizadeh, Aleksandr Filippov, Ammar Chaudhry, Julie A. Ressler, Julie Kilpatrick, Paige Myers-McNamara, Mike Chen, Leo D. Wang, Russell C. Rockne, Joseph Georges
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Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury Nat. Med. (IF 82.9) Pub Date : 2024-03-07 Caitlyn Vlasschaert, Cassianne Robinson-Cohen, Jianchun Chen, Elvis Akwo, Alyssa C. Parker, Samuel A. Silver, Pavan K. Bhatraju, Hannah Poisner, Shirong Cao, Ming Jiang, Yinqiu Wang, Aolei Niu, Edward Siew, Joseph C. Van Amburg, Holly J. Kramer, Anna Kottgen, Nora Franceschini, Bruce M. Psaty, Russell P. Tracy, Alvaro Alonso, Dan E. Arking, Josef Coresh, Christie M. Ballantyne, Eric Boerwinkle, Morgan
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Dozens of precision cancer drugs tested at lower doses to reduce side effects and cut costs Nat. Med. (IF 82.9) Pub Date : 2024-03-05
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Author Correction: The FGF21 analog pegozafermin in severe hypertriglyceridemia: a randomized phase 2 trial Nat. Med. (IF 82.9) Pub Date : 2024-03-04 Deepak L. Bhatt, Harold E. Bays, Michael Miller, James E. Cain, Katarzyna Wasilewska, Nabil S. Andrawis, Teresa Parli, Shibao Feng, Lulu Sterling, Leo Tseng, Cynthia L. Hartsfield, Germaine D. Agollah, Hank Mansbach, John J. P. Kastelein
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Type 1 diabetes: from the dream of automated insulin delivery to a fully artificial pancreas Nat. Med. (IF 82.9) Pub Date : 2024-03-06 Moshe Phillip, Aaron Kowalski, Tadej Battelino
Automated insulin delivery systems have transformed the care of people living with type 1 diabetes and continue to move closer to the ultimate goal of a fully autonomous artificial pancreas.
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Podcasts as a tool to disrupt knowledge hierarchies and silos to decolonize global health Nat. Med. (IF 82.9) Pub Date : 2024-03-05 Lindi van Niekerk, Stephanie M. Topp, Natalia Pasternak, Tim K. Mackey, Patricia Garcia, Agnes Binagwaho, Garry Aslanyan
The pursuit of health equity and social justice are often-stated core goals of global health practitioners, organizations and networks. However, the dynamic landscape of global health challenges and the historical and structural legacies of colonialism and imperialism mean that conventional approaches to knowledge production and sharing have often perpetuated, rather than reduced, health inequities
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Multi-ancestry polygenic mechanisms of type 2 diabetes Nat. Med. (IF 82.9) Pub Date : 2024-03-05 Kirk Smith, Aaron J. Deutsch, Carolyn McGrail, Hyunkyung Kim, Sarah Hsu, Alicia Huerta-Chagoya, Ravi Mandla, Philip H. Schroeder, Kenneth E. Westerman, Lukasz Szczerbinski, Timothy D. Majarian, Varinderpal Kaur, Alice Williamson, Noah Zaitlen, Melina Claussnitzer, Jose C. Florez, Alisa K. Manning, Josep M. Mercader, Kyle J. Gaulton, Miriam S. Udler
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Enhanced cholera surveillance to improve vaccination campaign efficiency Nat. Med. (IF 82.9) Pub Date : 2024-03-05 Hanmeng Xu, Kaiyue Zou, Juan Dent, Kirsten E. Wiens, Espoir Bwenge Malembaka, Godfrey Bwire, Placide Welo Okitayemba, Lee M. Hampton, Andrew S. Azman, Elizabeth C. Lee
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Minimally invasive derivation of primary human epithelial organoids from fetal fluids Nat. Med. (IF 82.9) Pub Date : 2024-03-04
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Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial Nat. Med. (IF 82.9) Pub Date : 2024-03-04 Feng Wang, Ying Jin, Min Wang, Hui-Yan Luo, Wei-Jia Fang, Ying-Nan Wang, Yan-Xing Chen, Run-Jie Huang, Wen-Long Guan, Ji-Bin Li, Yu-Hong Li, Feng-Hua Wang, Xiao-Hua Hu, Yan-Qiao Zhang, Miao-Zhen Qiu, Lu-Lu Liu, Zi-Xian Wang, Chao Ren, De-Shen Wang, Dong-Sheng Zhang, Zhi-Qiang Wang, Wen-Ting Liao, Lin Tian, Qi Zhao, Rui-Hua Xu
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Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids Nat. Med. (IF 82.9) Pub Date : 2024-03-04 Mattia Francesco Maria Gerli, Giuseppe Calà, Max Arran Beesley, Beatrice Sina, Lucinda Tullie, Kylin Yunyan Sun, Francesco Panariello, Federica Michielin, Joseph R. Davidson, Francesca Maria Russo, Brendan C. Jones, Dani Do Hyang Lee, Savvas Savvidis, Theodoros Xenakis, Ian C. Simcock, Anna A. Straatman-Iwanowska, Robert A. Hirst, Anna L. David, Christopher O’Callaghan, Alessandro Olivo, Simon Eaton
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A multi-ancestry genetic study of pain intensity in 598,339 veterans Nat. Med. (IF 82.9) Pub Date : 2024-03-01 Sylvanus Toikumo, Rachel Vickers-Smith, Zeal Jinwala, Heng Xu, Divya Saini, Emily E. Hartwell, Mirko Pavicic, Kyle A. Sullivan, Ke Xu, Daniel A. Jacobson, Joel Gelernter, Christopher T. Rentsch, Eli Stahl, Martin Cheatle, Hang Zhou, Stephen G. Waxman, Amy C. Justice, Rachel L. Kember, Henry R. Kranzler
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A gut microbial signature for combination immune checkpoint blockade across cancer types Nat. Med. (IF 82.9) Pub Date : 2024-03-01 Ashray Gunjur, Yan Shao, Timothy Rozday, Oliver Klein, Andre Mu, Bastiaan W. Haak, Ben Markman, Damien Kee, Matteo S. Carlino, Craig Underhill, Sophia Frentzas, Michael Michael, Bo Gao, Jodie Palmer, Jonathan Cebon, Andreas Behren, David J. Adams, Trevor D. Lawley
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The European Network for IgE-Mediated Autoimmunity and Autoallergy (ENIGMA) initiative Nat. Med. (IF 82.9) Pub Date : 2024-03-01 Pavel Kolkhir, Sabine Altrichter, Fariza Mishaal Saiema Badloe, Hafsa Belasri, Nicolas Charles, Shauni De Vriese, Jan Gutermuth, Lisa Huygen, Emek Kocatürk, Inge Kortekaas Krohn, Melba Muñoz, Sherezade Moñino-Romero, Laurent L. Reber, Jörg Scheffel, Carolin Steinert, Yi-Kui Xiang, Marcus Maurer
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Extreme weather events have lasting impacts on risk of death and healthcare utilization Nat. Med. (IF 82.9) Pub Date : 2024-02-29
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Improving the FITness of colorectal cancer screening Nat. Med. (IF 82.9) Pub Date : 2024-02-29
In a head-to-head study, a multitarget version of the widely used FIT (fecal immunochemical test) showed a higher cancer detection rate than the standard test.
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Recommendations to address respondent burden associated with patient-reported outcome assessment Nat. Med. (IF 82.9) Pub Date : 2024-02-29 Olalekan Lee Aiyegbusi, Samantha Cruz Rivera, Jessica Roydhouse, Paul Kamudoni, Yvonne Alder, Nicola Anderson, Robert Mitchell Baldwin, Vishal Bhatnagar, Jennifer Black, Andrew Bottomley, Michael Brundage, David Cella, Philip Collis, Elin-Haf Davies, Alastair K. Denniston, Fabio Efficace, Adrian Gardner, Ari Gnanasakthy, Robert M. Golub, Sarah E. Hughes, Flic Jeyes, Scottie Kern, Bellinda L. King-Kallimanis
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Impact of extreme weather events on healthcare utilization and mortality in the United States Nat. Med. (IF 82.9) Pub Date : 2024-02-29 Renee N. Salas, Laura G. Burke, Jessica Phelan, Gregory A. Wellenius, E. John Orav, Ashish K. Jha
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Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection Nat. Med. (IF 82.9) Pub Date : 2024-02-28 Matthias. T Stephan, Vladimir Ponomarev, Renier .J Brentjens, Alex. H Chang, Konstantin. V Dobrenkov, Glenn Heller, Michel Sadelain
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Phthalate exposure linked to adverse pregnancy outcomes Nat. Med. (IF 82.9) Pub Date : 2024-02-28
In a large US cohort of mother–child dyads, prenatal exposure to phthalate metabolites was associated with varying degrees of negative birth outcomes.
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To understand mRNA vaccine hesitancy, stop calling the public anti-science Nat. Med. (IF 82.9) Pub Date : 2024-02-27 Patrick Peretti-Watel, Pierre Verger, Jeremy K. Ward
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Implementation of community screening strategies for depression Nat. Med. (IF 82.9) Pub Date : 2024-02-27 Jorge Arias de la Torre, Amy Ronaldson, Gemma Vilagut, Gonzalo Martínez-Alés, Alex Dregan, Ioannis Bakolis, Jose M. Valderas, Antonio J. Molina, Vicente Martín, Juan Ángel Bellón, Jordi Alonso
Community screening could be used for the monitoring, early detection and prevention of for depression, and to maximize the effects of the policies to reduce its burden.
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Adapted large language models can outperform medical experts in clinical text summarization Nat. Med. (IF 82.9) Pub Date : 2024-02-27 Dave Van Veen, Cara Van Uden, Louis Blankemeier, Jean-Benoit Delbrouck, Asad Aali, Christian Bluethgen, Anuj Pareek, Malgorzata Polacin, Eduardo Pontes Reis, Anna Seehofnerová, Nidhi Rohatgi, Poonam Hosamani, William Collins, Neera Ahuja, Curtis P. Langlotz, Jason Hom, Sergios Gatidis, John Pauly, Akshay S. Chaudhari
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Expanding the reach and scalability of perinatal mental health interventions Nat. Med. (IF 82.9) Pub Date : 2024-02-26 Daisy R. Singla
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Immunotherapy at all stages of hepatocellular carcinoma Nat. Med. (IF 82.9) Pub Date : 2024-02-26 David J. Pinato, Claudia A. M. Fulgenzi, Antonio D’Alessio
A flurry of emerging treatment options is transforming the therapeutic landscape of hepatocellular carcinoma; two new studies highlight the complexities and gaps in knowledge, but also hint at a greater understanding of how to apply immunotherapy in early and advanced disease.
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Ambitious birth cohort study tracks genetic links to health in China Nat. Med. (IF 82.9) Pub Date : 2024-02-26
The Born in Guangzhou Cohort Study prospectively collects genetic and phenotypic data from thousands of families, providing insights into genetics, early-life exposures and long-term health.
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Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade Nat. Med. (IF 82.9) Pub Date : 2024-02-22
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To do no harm — and the most good — with AI in health care Nat. Med. (IF 82.9) Pub Date : 2024-02-22 Carey Beth Goldberg, Laura Adams, David Blumenthal, Patricia Flatley Brennan, Noah Brown, Atul J. Butte, Morgan Cheatham, Dave deBronkart, Jennifer Dixon, Jeffrey Drazen, Barbara J. Evans, Sara M. Hoffman, Chris Holmes, Peter Lee, Arjun Kumar Manrai, Gilbert S. Omenn, Jonathan B. Perlin, Rachel Ramoni, Guillermo Sapiro, Rupa Sarkar, Harpreet Sood, Effy Vayena, Isaac S. Kohane
Drawing from real-life scenarios and insights shared at the RAISE (Responsible AI for Social and Ethical Healthcare) conference, we highlight the critical need for AI in health care (AIH) to primarily benefit patients and address current shortcomings in health care systems such as medical errors and access disparities.
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Author Correction: An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation Nat. Med. (IF 82.9) Pub Date : 2024-02-21 George. P Souroullas, William. R Jeck, Joel. S Parker, Jeremy. M Simon, Jie-Yu Liu, Joshiawa Paulk, Jessie Xiong, Kelly. S Clark, Yuri Fedoriw, Jun Qi, Christin. E Burd, James. E Bradner, Norman. E Sharpless
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Highly Accurate Blood Test for Alzheimer’s Disease Comparable or Superior to Clinical CSF Tests Nat. Med. (IF 82.9) Pub Date : 2024-02-21 Nicolas R. Barthélemy, Gemma Salvadó, Suzanne Schindler, Yingxin He, Shorena Janelidze, Lyduine E. Collij, Benjamin Saef, Rachel L. Henson, Charles D. Chen, Brian A. Gordon, Yan Li, Renaud La Joie, Tammie L. S. Benzinger, John C. Morris, Niklas Mattsson-Carlgren, Sebastian Palmqvist, Rik Ossenkoppele, Gil D. Rabinovici, Erik Stomrud, Randall J. Bateman, Oskar Hansson
With the emergence of Alzheimer’s disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes critical. We evaluated whether a precise blood test could perform as well as established cerebrospinal fluid (CSF) tests in detecting amyloid-β (Aβ) plaques and tau tangles. Plasma %p-tau217 (ratio of phosporylated-tau217 to non-phosphorylated tau) was analyzed
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Closing the global gap in adolescent mental health Nat. Med. (IF 82.9) Pub Date : 2024-02-20
Effective and sustainable interventions to address the global burden of mental disorders in children and adolescents require evidence-based research that fully acknowledges the social, cultural and economic challenges.
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Clinical surveillance systems obscure the true cholera infection burden in an endemic region Nat. Med. (IF 82.9) Pub Date : 2024-02-20 Sonia T. Hegde, Ashraful Islam Khan, Javier Perez-Saez, Ishtiakul Islam Khan, Juan Dent Hulse, Md Taufiqul Islam, Zahid Hasan Khan, Shakeel Ahmed, Taner Bertuna, Mamunur Rashid, Rumana Rashid, Md Zakir Hossain, Tahmina Shirin, Kirsten E. Wiens, Emily S. Gurley, Taufiqur Rahman Bhuiyan, Firdausi Qadri, Andrew S. Azman
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Digital intervention improves tuberculosis treatment outcomes Nat. Med. (IF 82.9) Pub Date : 2024-02-19
An intervention that incorporates electronic pill boxes and remote adherence monitoring improved treatment success in patients with tuberculosis in Tibet — making this a promising strategy for low-resource settings.
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Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations Nat. Med. (IF 82.9) Pub Date : 2024-02-19 Niall J. Lennon, Leah C. Kottyan, Christopher Kachulis, Noura S. Abul-Husn, Josh Arias, Gillian Belbin, Jennifer E. Below, Sonja I. Berndt, Wendy K. Chung, James J. Cimino, Ellen Wright Clayton, John J. Connolly, David R. Crosslin, Ozan Dikilitas, Digna R. Velez Edwards, QiPing Feng, Marissa Fisher, Robert R. Freimuth, Tian Ge, Joseph T. Glessner, Adam S. Gordon, Candace Patterson, Hakon Hakonarson
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Considerations for clinical implementation of polygenic risk scores in diverse US populations Nat. Med. (IF 82.9) Pub Date : 2024-02-19
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The All of Us Research Program is an opportunity to enhance the diversity of US biomedical research Nat. Med. (IF 82.9) Pub Date : 2024-02-19 Diana W. Bianchi, Patricia Flatley Brennan, Michael F. Chiang, Lindsey A. Criswell, Rena N. D’Souza, Gary H. Gibbons, James K. Gilman, Joshua A. Gordon, Eric D. Green, Susan Gregurick, Richard J. Hodes, Peter H. Kilmarx, George F. Koob, Walter J. Koroshetz, Helene M. Langevin, Jon R. Lorsch, Jeanne M. Marrazzo, Eliseo J. Pérez-Stable, W. Kimryn Rathmell, Griffin P. Rodgers, Joni L. Rutter, Jane M.
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A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk Nat. Med. (IF 82.9) Pub Date : 2024-02-19 Marc Ferrell, Zeneng Wang, James T. Anderson, Xinmin S. Li, Marco Witkowski, Joseph A. DiDonato, James R. Hilser, Jaana A. Hartiala, Arash Haghikia, Tomas Cajka, Oliver Fiehn, Naseer Sangwan, Ilja Demuth, Maximilian König, Elisabeth Steinhagen-Thiessen, Ulf Landmesser, W. H. Wilson Tang, Hooman Allayee, Stanley L. Hazen
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Regorafenib plus nivolumab in unresectable hepatocellular carcinoma: the phase 2 RENOBATE trial Nat. Med. (IF 82.9) Pub Date : 2024-02-19 Hyung-Don Kim, Seyoung Jung, Ho Yeong Lim, Baek-Yeol Ryoo, Min-Hee Ryu, Samuel Chuah, Hong Jae Chon, Beodeul Kang, Jung Yong Hong, Han Chu Lee, Deok-Bog Moon, Ki-Hun Kim, Tae Won Kim, David Tai, Valerie Chew, Jeong Seok Lee, Richard S. Finn, June-Young Koh, Changhoon Yoo
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Anxiety-focused cognitive behavioral therapy delivered by non-specialists to prevent postnatal depression: a randomized, phase 3 trial Nat. Med. (IF 82.9) Pub Date : 2024-02-16 Pamela J. Surkan, Abid Malik, Jamie Perin, Najia Atif, Armaan Rowther, Ahmed Zaidi, Atif Rahman
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Anticoagulation with osocimab in patients with kidney failure undergoing hemodialysis: a randomized phase 2 trial Nat. Med. (IF 82.9) Pub Date : 2024-02-16 Jeffrey I. Weitz, László B. Tankó, Jürgen Floege, Keith A. A. Fox, Deepak L. Bhatt, Ravi Thadhani, James Hung, Ákos F. Pap, Dagmar Kubitza, Wolfgang C. Winkelmayer
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A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial Nat. Med. (IF 82.9) Pub Date : 2024-02-16 Andreas H. Diacon, Clifton E. Barry, Alex Carlton, Ray Y. Chen, Matt Davies, Veronique de Jager, Kim Fletcher, Gavin C. K. W. Koh, Irina Kontsevaya, Jan Heyckendorf, Christoph Lange, Maja Reimann, Sophie L. Penman, Rhona Scott, Gareth Maher-Edwards, Simon Tiberi, Georgios Vlasakakis, Caryn M. Upton, David Barros Aguirre
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Longitudinal gut microbiome changes in immune checkpoint blockade-treated advanced melanoma Nat. Med. (IF 82.9) Pub Date : 2024-02-16 Johannes R. Björk, Laura A. Bolte, Andrew Maltez Thomas, Karla A. Lee, Niccolo Rossi, Thijs T. Wind, Lotte M. Smit, Federica Armanini, Francesco Asnicar, Aitor Blanco-Miguez, Ruth Board, Neus Calbet-Llopart, Lisa Derosa, Nathalie Dhomen, Kelly Brooks, Mark Harland, Mark Harries, Paul Lorigan, Paolo Manghi, Richard Marais, Julia Newton-Bishop, Luigi Nezi, Federica Pinto, Miriam Potrony, Susana Puig