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Transcription Factor GATA4 Regulates Cell Type–Specific Splicing Through Direct Interaction With RNA in Human Induced Pluripotent Stem Cell–Derived Cardiac Progenitors Circulation (IF 39.918) Pub Date : 2022-08-08 Lili Zhu, Krishna Choudhary, Barbara Gonzalez-Teran, Yen-Sin Ang, Reuben Thomas, Nicole R. Stone, Lei Liu, Ping Zhou, Chenchen Zhu, Hongmei Ruan, Yu Huang, Shibo Jin, Angelo Pelonero, Frances Koback, Arun Padmanabhan, Nandhini Sadagopan, Austin Hsu, Mauro W. Costa, Casey A. Gifford, Joke van Bemmel, Ruth Hüttenhain, Vasanth Vedantham, Bruce R. Conklin, Brian L. Black, Benoit G. Bruneau, Lars Steinmetz
Background:GATA4 (GATA-binding protein 4), a zinc finger–containing, DNA-binding transcription factor, is essential for normal cardiac development and homeostasis in mice and humans, and mutations in this gene have been reported in human heart defects. Defects in alternative splicing are associated with many heart diseases, yet relatively little is known about how cell type– or cell state–specific
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Bending Oxygen Saturation index (BOSI) and Risk of Worsening Heart Failure Events in Chronic Heart Failure Eur. J. Heart Fail. (IF 17.349) Pub Date : 2022-08-06 Rafael de la Espriella, Martina Amiguet, Gema Miñana, Juan Carlos Rodríguez, Patricia Moyano, Daniel Segarra, Julio Fernández, Enrique Santas, Gonzalo Núñez, Miguel Lorenzo, Clara Bonanad, Edgardo Alania, Alfonso Valle, Juan Sanchis, Vicent Bodí, Jose Luis Górriz, Jorge Navarro, Pau Codina, Adriaan A. Voors, Antoni Bayés-Genís, Julio Núñez
Bendopnea is a clinical symptom of advanced heart failure (HF) with uncertain prognostic value. We aimed to evaluate whether bendopnea and the change in oxygen saturation when bending forward (Bending Oxygen Saturation Index -BOSI-) are associated with adverse outcomes in ambulatory chronic heart failure (CHF) patients.
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Liver tests and outcomes in heart failure with reduced ejection fraction: Findings from DAPA-HF Eur. J. Heart Fail. (IF 17.349) Pub Date : 2022-08-06 Carly Adamson, Lorna M Cowan, Rudolf A. de Boer, Mirta Diez, Jarosław Drożdż, Andre Dukát, Silvio E. Inzucchi, Lars Køber, Mikhail N. Kosiborod, Charlotta E.A. Ljungman, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, Daniel Lindholm, Olof Bengtsson, David W. Boulton, Peter J. Greasley, Anna Maria Langkilde, Mikaela Sjöstrand, Scott D Solomon, John JV McMurray, Pardeep S Jhund
Reflecting both increased venous pressure and reduced cardiac output, abnormal liver tests are common in patients with severe heart failure and are associated adverse clinical outcomes. We aimed to investigate the prognostic significance of abnormal liver tests in ambulatory patients with heart failure with reduced ejection fraction (HFrEF), explore any treatment interaction between bilirubin and sodium-glucose
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Atrial amyloidosis: mechanisms and clinical manifestations Eur. J. Heart Fail. (IF 17.349) Pub Date : 2022-08-03 Giuseppe Vergaro, Alberto Aimo, Claudio Rapezzi, Vincenzo Castiglione, Iacopo Fabiani, Angela Pucci, Gabriele Buda, Claudio Passino, Josep Lupón, Antoni Bayes-Genis, Michele Emdin, Eugene Braunwald
Cardiac amyloidosis (CA) is now recognized as an important cause of heart failure. Increased wall thickness and diastolic dysfunction of the left ventricle (LV) are the most easily detectable manifestations of CA, but amyloid accumulates in all cardiac structures. Involvement of the left and right atria may be due to the haemodynamic effects of ventricular diastolic dysfunction, the effects of amyloid
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Sulfide regulation of cardiovascular function in health and disease Nat. Rev. Cardiol. (IF 49.421) Pub Date : 2022-08-05 Gopi K. Kolluru, Rodney E. Shackelford, Xinggui Shen, Paari Dominic, Christopher G. Kevil
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In This Issue Circ. Res. (IF 23.213) Pub Date : 2022-08-04 Ruth Williams
When a cell is stressed, it often accumulates clumps of misfolded proteins, which in turn trigger reduced protein translation and reprogramming of gene transcription—collectively known as the unfolded protein response (UPR). Because platelets have no nuclei, and thus no transcription, it was possible they lacked a UPR, but Jain and colleagues now show this is not the case. They found that treating
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Meet the First Authors Circ. Res. (IF 23.213) Pub Date : 2022-08-04
Dr Kanika Jain is an Associate Research Scientist at Yale University School of Medicine. Her fascination with proteostasis and multifaceted Unfolded Protein Response (UPR) began during her PhD. As a postdoctoral fellow under the mentorship of Dr John Hwa, she became interested in the anucleate platelets. She now investigates the role of UPR and stress induced signaling in regulation of platelet function
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Correction to: Heart Failure with Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models Circ. Res. (IF 23.213) Pub Date : 2022-08-04
In the article by Roh et al, “Heart Failure with Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models,” which was published in the June 10, 2022 issue (Circ Res. 2022;130:1906–1925, doi: 10.1161/CIRCRESAHA.122.320257), a correction was needed. The below reference 117 should be cited on page 10: Sharp TE 3rd, Scarborough AL, Li Z, Polhemus DJ, Hidalgo HA, Schumacher JD, Matsuura
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Exerkine fibronectin type-III domain-containing protein 5/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability Eur. Heart J. (IF 35.855) Pub Date : 2022-08-05 Chen Chi, Hui Fu, Yong-Hua Li, Guo-Yan Zhang, Fei-Yan Zeng, Qing-Xin Ji, Qi-Rui Shen, Xu-Jie Wang, Zi-Chen Li, Can-Can Zhou, Di-Yang Sun, Jiang-Tao Fu, Wen-Bin Wu, Ping-Ping Zhang, Jia-Bao Zhang, Jian Liu, Fu-Ming Shen, Dong-Jie Li, Pei Wang
Aims Exercise confers protection against cardiovascular ageing, but the mechanisms remain largely unknown. This study sought to investigate the role of fibronectin type-III domain-containing protein 5 (FNDC5)/irisin, an exercise-associated hormone, in vascular ageing. Moreover, the existence of FNDC5/irisin in circulating extracellular vesicles (EVs) and their biological functions was explored. Methods
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Transthyretin cardiac amyloidosis Cardiovasc. Res. (IF 13.081) Pub Date : 2022-08-05 Aldostefano Porcari, Marianna Fontana, Julian D Gillmore
Transthyretin cardiac amyloidosis (ATTR-CA) is an increasingly recognized cause of heart failure (HF) and mortality worldwide. Advances in non-invasive diagnosis, coupled with the development of effective treatments, have shifted ATTR-CA from a rare and untreatable disease to a relatively prevalent condition that clinicians should consider on a daily basis. Amyloid fibril formation results from age-related
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Trends in survival after cardiac arrest: a Swedish nationwide study over 30 years Eur. Heart J. (IF 35.855) Pub Date : 2022-08-04 Matilda Jerkeman, Pedram Sultanian, Peter Lundgren, Niklas Nielsen, Edvin Helleryd, Christian Dworeck, Elmir Omerovic, Per Nordberg, Annika Rosengren, Jacob Hollenberg, Andreas Claesson, Solveig Aune, Anneli Strömsöe, Annica Ravn-Fischer, Hans Friberg, Johan Herlitz, Araz Rawshani
Aims Trends in characteristics, management, and survival in out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA) were studied in the Swedish Cardiopulmonary Resuscitation Registry (SCRR). Methods and results The SCRR was used to study 106 296 cases of OHCA (1990–2020) and 30 032 cases of IHCA (2004–20) in whom resuscitation was attempted. In OHCA, survival increased from 5.7%
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Cardiovascular effects of incretins: focus on glucagon-like peptide-1 receptor agonists Cardiovasc. Res. (IF 13.081) Pub Date : 2022-08-04 Sten Madsbad, Jens J Holst
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been used to treat patients with type 2 diabetes since 2005 and have become popular because of the efficacy and durability in relation to glycaemic control in combination with weight loss in most patients. Today in 2022, seven GLP-1 RAs, including oral semaglutide are available for treatment of type 2 diabetes. Since the efficacy in relation
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LPA2 Contributes to Vascular Endothelium Homeostasis and Cardiac Remodeling After Myocardial Infarction Circ. Res. (IF 23.213) Pub Date : 2022-08-03 Jianqiu Pei, Lin Cai, Fang Wang, Chuansheng Xu, Shengqiang Pei, Hongwei Guo, Xiaogang Sun, Jerold Chun, Xiangfeng Cong, Weiquan Zhu, Zhe Zheng, Xi Chen
Rationale:Myocardial infarction (MI) is one of the most dangerous adverse cardiovascular events. Our previous study found that lysophosphatidic acid (LPA) is increased in human peripheral blood after MI, and LPA has a protective effect on the survival and proliferation of various cell types. However, the role of LPA and its receptors in MI is less understood.Objectives:To study the unknown role of
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Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes Circ. Res. (IF 23.213) Pub Date : 2022-08-03 Wenqian Cai, Dacai Xu, Chui Zeng, Fan Liao, Ruiqi Li, Yingjiong Lin, Yue Zhao, Wenyan Dong, Qingwen Wang, Haili Yang, Daqiang Wen, Jianbiao Gu, Weihui Shentu, Hongkui Yu, Xiaochun Zhang, Jianrui Wei, Jinzhu Duan
Background:Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as a post-translational histone modification that robustly indicates active promoters. However, the role of Kcr in myocardial injury is unknown. In this study, we aimed to clarify the pathophysiological significance of Kcr in cardiac
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RESPONSE: Fostering an ACHD Clinician Pipeline J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Arwa Saidi, Karen K. Stout
Abstract not available
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Performance of Control Groups in Early Childhood Health Promotion Trials J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Gloria Santos-Beneit, Rodrigo Fernandez-Jimenez, Amaya de Cos-Gandoy, Patricia Bodega, Raquel Diaz-Munoz, Christopher A. Hill, Alexandra Turco, Maribel Santana, Risa Jaslow, Carlos Peyra, Isabel Carvajal, Valentin Fuster
Abstract not available
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Pregnancy among cardiologists: challenges and recommendations Nat. Rev. Cardiol. (IF 49.421) Pub Date : 2022-08-02 Inbar Raber, Amy A. Sarma
Childbearing cardiologists face a number of challenges before, during and after pregnancy, including radiation concerns, infertility, pregnancy-related complications, and inadequate parental leave and return-to-work structures. Institutions can promote an equitable work environment by creating policies to mitigate these challenges.
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Multinational Federated Learning Approach to Train ECG and Echocardiogram Models for Hypertrophic Cardiomyopathy Detection Circulation (IF 39.918) Pub Date : 2022-08-02 Shinichi Goto, Divyarajsinhji Solanki, Jenine E. John, Ryuichiro Yagi, Max Homilius, Genki Ichihara, Yoshinori Katsumata, Hanna K. Gaggin, Yuji Itabashi, Calum A. MacRae, Rahul C. Deo
Background:Novel targeted treatments increase the need for prompt hypertrophic cardiomyopathy (HCM) detection. However, its low prevalence (0.5%) and resemblance to common diseases present challenges that may benefit from automated machine learning–based approaches. We aimed to develop machine learning models to detect HCM and to differentiate it from other cardiac conditions using ECGs and echocardiograms
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Sex differences among patients with transthyretin amyloid cardiomyopathy – from diagnosis to prognosis Eur. J. Heart Fail. (IF 17.349) Pub Date : 2022-08-02 Rishi K Patel, Adam Ioannou, Yousuf Razvi, Liza Chacko, Lucia Venneri, Francesco Bandera, Daniel Knight, Tushar Kotecha, Ana Martinez-Naharro, Ambra Masi, Aldostefano Porcari, James Brown, Kiara Patel, Charlotte Manisty, James Moon, Dorota Rowczenio, Janet A Gilbertson, Gianfranco Sinagra, Helen Lachmann, Ashutosh Wechalekar, Aviva Petrie, Carol Whelan, Philip N Hawkins, Julian D Gillmore, Marianna
Transthyretin amyloid cardiomyopathy (ATTR-CM) is predominantly diagnosed in men. The few available studies suggest affected women have a more favourable cardiac phenotype. We aimed to characterise sex differences among consecutive patients with non-hereditary and two prevalent forms of hereditary ATTR-CM diagnosed over a 20-year period.
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Trajectories in New York heart association functional class across the ejection fraction spectrum: data from the Swedish Heart Failure registry Eur. J. Heart Fail. (IF 17.349) Pub Date : 2022-08-02 Felix Lindberg, Lars H Lund, Lina Benson, Ulf Dahlström, Patric Karlström, Cecilia Linde, Giuseppe Rosano, Gianluigi Savarese
To investigate incidence, predictors and prognostic implications of longitudinal New York Heart Association (NYHA) class changes (i.e. improving or worsening vs. stable NYHA class) in heart failure (HF) across the ejection fraction (EF) spectrum.
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Cardiovascular Disease Projections in the United States Based on the 2020 Census Estimates J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Reza Mohebi, Chen Chen, Nasrien E. Ibrahim, Cian P. McCarthy, Hanna K. Gaggin, Daniel E. Singer, Emily P. Hyle, Jason H. Wasfy, James L. Januzzi
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Worsening Cardiovascular Disease Epidemiology in the United States J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Andreas P. Kalogeropoulos, Javed Butler
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Sustained-Release Ivabradine Hemisulfate in Patients With Systolic Heart Failure J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Feiming Ye, Xiaofeng Wang, Shulin Wu, Shumei Ma, Yu Zhang, Gang Liu, Kunshen Liu, Zhiming Yang, Xiaohua Pang, Li Xue, Shijuan Lu, Ming Zhong, Jing Li, Hao Yu, Donghua Lou, Dongyang Cui, Xiaojie Xie, Jian’an Wang
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The Challenge of Reducing Complexity of Heart Failure Treatment Without Losing Efficacy J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Edimar Alcides Bocchi, Ivna Girard Cunha Vieira Lima
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Cardiorespiratory Fitness and Mortality Risk Across the Spectra of Age, Race, and Sex J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Peter Kokkinos, Charles Faselis, Immanuel Babu Henry Samuel, Andreas Pittaras, Michael Doumas, Rayelynn Murphy, Michael S. Heimall, Xuemei Sui, Jiajia Zhang, Jonathan Myers
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Fit Is It for Longevity Across Populations∗ J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Carl J. Lavie, Fabian Sanchis-Gomar, Cemal Ozemek
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Deep Learning Electrocardiographic Analysis for Detection of Left-Sided Valvular Heart Disease J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Pierre Elias, Timothy J. Poterucha, Vijay Rajaram, Luca Matos Moller, Victor Rodriguez, Shreyas Bhave, Rebecca T. Hahn, Geoffrey Tison, Sean A. Abreau, Joshua Barrios, Jessica Nicole Torres, J. Weston Hughes, Marco V. Perez, Joshua Finer, Susheel Kodali, Omar Khalique, Nadira Hamid, Allan Schwartz, Adler J. Perotte
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The Future of AI-Enhanced ECG Interpretation for Valvular Heart Disease Screening∗ J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Ambarish Pandey, Demilade Adedinsewo
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Impact of the COVID-19 Pandemic on Cardiovascular Health in 2020 J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Gregory A. Roth, Muthiah Vaduganathan, George A. Mensah
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Sparking the Fire in Adult Congenital Heart Disease J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Katia Bravo-Jaimes, Carla Rodriguez-Montserrate, Valeria E. Duarte
Abstract not available
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Gun Violence J. Am. Coll. Cardiol. (IF 27.203) Pub Date : 2022-08-01 Edward T.A. Fry
Abstract not available
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Sleep-Disordered Breathing and Cardiac Arrhythmias in Adults: Mechanistic Insights and Clinical Implications: A Scientific Statement From the American Heart Association Circulation (IF 39.918) Pub Date : 2022-08-01 Reena Mehra, Mina K. Chung, Brian Olshansky, Dobromir Dobrev, Chandra L. Jackson, Vaishnavi Kundel, Dominik Linz, Nancy S. Redeker, Susan Redline, Prashanthan Sanders, Virend K. Somers, on behalf of the American Heart Association Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, and Stroke Council
Sleep-disordered breathing (SDB), characterized by specific underlying physiological mechanisms, comprises obstructive and central pathophysiology, affects nearly 1 billion individuals worldwide, and is associated with excessive cardiopulmonary morbidity. Strong evidence implicates SDB in cardiac arrhythmogenesis. Immediate consequences of SDB include autonomic nervous system fluctuations, recurrent
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Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial Eur. Heart J. (IF 35.855) Pub Date : 2022-08-01 Theresa-Marie Dachs, Franz Duca, René Rettl, Christina Binder-Rodriguez, Daniel Dalos, Luciana Camuz Ligios, Andreas Kammerlander, Ekkehard Grünig, Ingrid Pretsch, Regina Steringer-Mascherbauer, Klemens Ablasser, Manfred Wargenau, Julia Mascherbauer, Irene M Lang, Christian Hengstenberg, Roza Badr-Eslam, Johannes Kastner, Diana Bonderman
Aims The presence of pulmonary hypertension (PH) severely aggravates the clinical course of heart failure with preserved ejection fraction (HFpEF). To date, neither established heart failure therapies nor pulmonary vasodilators proved beneficial. This study investigated the efficacy of chronic treatment with the oral soluble guanylate cyclase stimulator riociguat in patients with PH-HFpEF. Methods
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Evolution of tricuspid regurgitation after transcatheter edge-to-edge mitral valve repair for secondary mitral regurgitation and its impact on mortality Eur. J. Heart Fail. (IF 17.349) Pub Date : 2022-08-01 Marianna Adamo, Matteo Pagnesi, Giulia Ghizzoni, Rodrigo Estévez-Loureiro, Sergio Raposeiras-Roubin, Daniela Tomasoni, Davide Stolfo, Gianfranco Sinagra, Antonio Popolo Rubbio, Francesco Bedogni, Federico De Marco, Cristina Giannini, Anna Sonia Petronio, Laura Stazzoni, Tomás Benito-González, Felipe Fernández-Vázquez, Carmen Garrote-Coloma, Cosmo Godino, Eustachio Agricola, Andrea Munafò, Isaac Pascual
To evaluate short-term changes in tricuspid regurgitation (TR) after transcatheter edge-to-edge repair (M-TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality.
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Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes Cardiovasc. Res. (IF 13.081) Pub Date : 2022-07-29 Yutang Wang, Yan Fang, Dianna J Magliano, Fadi J Charchar, Christopher G Sobey, Grant R Drummond, Jonathan Golledge
Aims We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality. Methods and results This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs)
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Quantifying the impact of gut microbiota on inflammation and hypertensive organ damage Cardiovasc. Res. (IF 13.081) Pub Date : 2022-07-29 Ellen G Avery, Hendrik Bartolomaeus, Ariana Rauch, Chia-Yu Chen, Gabriele N’Diaye, Ulrike Löber, Theda U P Bartolomaeus, Raphaela Fritsche-Guenther, André F Rodrigues, Alex Yarritu, Cheng Zhong, Lingyan Fei, Dmitry Tsvetkov, Mihail Todiras, Joon-Keun Park, Lajos Markó, András Maifeld, Andreas Patzak, Michael Bader, Stefan Kempa, Jennifer A Kirwan, Sofia K Forslund, Dominik N Müller, Nicola Wilck
Aims Hypertension (HTN) can lead to heart and kidney damage. The gut microbiota has been linked to HTN, although it is difficult to estimate its significance due to the variety of other features known to influence HTN. In the present study, we used germ-free (GF) and colonized (COL) littermate mice to quantify the impact of microbial colonization on organ damage in HTN. Methods and results Four-week-old
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Myeloid leukocytes’ diverse effects on cardiovascular and systemic inflammation in chronic kidney disease Basic Res. Cardiol. (IF 12.416) Pub Date : 2022-07-27 Alexander Hof, Simon Geißen, Kezia Singgih, Martin Mollenhauer, Holger Winkels, Thomas Benzing, Stephan Baldus, Friedrich Felix Hoyer
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Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis Circ. Res. (IF 23.213) Pub Date : 2022-07-28 Jiang-Yun Luo, Chak Kwong Cheng, Lei He, Yujie Pu, Yang Zhang, Xiao Lin, Aimin Xu, Chi Wai Lau, Xiao Yu Tian, Ronald Ching Wan Ma, Hanjoong Jo, Yu Huang
Background:Inflamed endothelial cells (ECs) trigger atherogenesis, especially at arterial regions experiencing disturbed blood flow. UCP2 (Uncoupling protein 2), a key mitochondrial antioxidant protein, improves endothelium-dependent relaxation in obese mice. However, whether UCP2 can be regulated by shear flow is unknown, and the role of endothelial UCP2 in regulating inflammation and atherosclerosis
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Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation Circ. Res. (IF 23.213) Pub Date : 2022-07-28 Qing Wan, Chuansheng Xu, Liyuan Zhu, Yuze Zhang, Zekun Peng, Hong Chen, Haojie Rao, Erli Zhang, Hongyue Wang, Fei Chu, Xuan Ning, Xuejian Yang, Jinqing Yuan, Yongjian Wu, Yu Huang, Shengshou Hu, De-Pei Liu, Miao Wang
Background:Timely and complete restoration of blood flow is the most effective intervention for patients with acute myocardial infarction. However, the efficacy is limited by myocardial ischemia-reperfusion (MI/R) injury. PDE4 (phosphodiesterase-4) hydrolyzes intracellular cAMP and it has 4 subtypes A-D. This study aimed to delineate the role of PDE4B (phosphodiesterase-4 subtype B) in MI/R injury
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Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia Circulation (IF 39.918) Pub Date : 2022-07-28 Wieneke Dijk, Mathilde Di Filippo, Sander Kooijman, Robin van Eenige, Antoine Rimbert, Amandine Caillaud, Aurélie Thedrez, Lucie Arnaud, Amanda Pronk, Damien Garçon, Thibaud Sotin, Pierre Lindenbaum, Enrique Ozcariz Garcia, Jean-Paul Pais de Barros, Laurence Duvillard, Karim Si-Tayeb, Nuria Amigo, Jean-Yves Le Questel, Patrick C.N. Rensen, Cedric Le May, Philippe Moulin, Bertrand Cariou
BACKGROUND:Atherosclerotic cardiovascular disease is the main cause of mortality worldwide and is strongly influenced by circulating low-density lipoprotein (LDL) cholesterol levels. Only a few genes causally related to plasma LDL cholesterol levels have been identified so far, and only 1 gene, ANGPTL3, has been causally related to combined hypocholesterolemia. Here, our aim was to elucidate the genetic
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Longitudinal Trajectories in Renal Function Before and After Heart Failure Hospitalization Among Patients with HFpEF in the PARAGON-HF Trial Eur. J. Heart Fail. (IF 17.349) Pub Date : 2022-07-27 Safia Chatur, Muthiah Vaduganathan, Alexander Peikert, Brian L Claggett, Finnian R. McCausland, Hicham Skali, Marc A. Pfeffer, Iris E Beldhuis, Lars Kober, Petar Seferovic, Martin Lefkowitz, John JV McMurray, Scott D. Solomon
Worsening renal function may impact long-term outcomes in heart failure (HF). However, little is known about the longitudinal trajectories in renal function in relation to the HF hospitalization or how this high-risk clinical event impacts renal outcomes.
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Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial Eur. Heart J. (IF 35.855) Pub Date : 2022-07-28 Javed Butler, Stefan D Anker, Lars H Lund, Andrew J S Coats, Gerasimos Filippatos, Tariq Jamal Siddiqi, Tim Friede, Vincent Fabien, Mikhail Kosiborod, Marco Metra, Ileana L Piña, Fausto Pinto, Patrick Rossignol, Peter van der Meer, Cecilia Bahit, Jan Belohlavek, Michael Böhm, Jasper J Brugts, John GF Cleland, Justin Ezekowitz, Antoni Bayes-Genis, Israel Gotsman, Assen Goudev, Irakli Khintibidze, Joann
Aims To investigate the impact of patiromer on serum potassium level and its ability to enable specified target doses of renin-angiotensin-aldosterone system inhibitor (RAASi) use in patients with heart failure and reduced ejection fraction (HFrEF). Methods and results A total of 1642 patients with HFrEF and current or a history of RAASi-related hyperkalemia were screened and 1195 were enrolled in
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From novel discovery tools and biomarkers to precision medicine - basic cardiovascular science highlights of 2021/2022 Cardiovasc. Res. (IF 13.081) Pub Date : 2022-07-28 Paul C Evans, Sean M Davidson, Johann Wojta, Magnus Bäck, Sveva Bollini, Mairi Brittan, Alberico L Catapano, Bill Chaudhry, Matthijs Cluitmans, Massimiliano Gnecchi, Tomasz J Guzik, Imo Hoefer, Rosalinda Madonna, João P Monteiro, Henning Morawietz, Elena Osto, Teresa Padró, Judith C Sluimer, Carlo Gabriele Tocchetti, Kim Van der Heiden, Gemma Vilahur, Johannes Waltenberger, Christian Weber
Here we review the highlights of cardiovascular basic science in published in 2021 and early 2022 on behalf of the European Society of Cardiology Council for Basic Cardiovascular Science. We begin with non-coding RNAs which have emerged as central regulators cardiovascular biology, and then discuss how technological developments in single-cell ‘omics are providing new insights in cardiovascular development
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Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction Circ. Res. (IF 23.213) Pub Date : 2022-07-27 Lu Wang, Lizhu Lin, Hui Qi, Ju Chen, Paul Grossfeld
Rationale:Jacobsen syndrome is a rare chromosomal disorder caused by deletions in the long arm of human chromosome 11, resulting in multiple developmental defects including congenital heart defects. Combined studies in humans and genetically engineered mice implicate that loss of ETS1 (E26 transformation specific 1) is the cause of congenital heart defects in Jacobsen syndrome, but the underlying molecular
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Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease Circ. Res. (IF 23.213) Pub Date : 2022-07-27 Hongliang Xue, Xu Chen, Chao Yu, Yuqing Deng, Yuan Zhang, Shen Chen, Xuechen Chen, Ke Chen, Yan Yang, Wenhua Ling
BACKGROUND:Accumulating evidence has shown that disorders in the gut microbiota and derived metabolites affect the development of atherosclerotic cardiovascular disease (ASCVD). However, which and how specific gut microbial metabolites contribute to the progression of atherosclerosis and the clinical relevance of their alterations remain unclear.METHODS:We performed integrated microbiome–metabolome
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Hypertension in children and adolescents Eur. Heart J. (IF 35.855) Pub Date : 2022-07-27 Giovanni de Simone, Costantino Mancusi, Henner Hanssen, Simonetta Genovesi, Empar Lurbe, Gianfranco Parati, Skaiste Sendzikaite, Giuliana Valerio, Procolo Di Bonito, Giovanni Di Salvo, Marc Ferrini, Paul Leeson, Philip Moons, Constance G Weismann, Bryan Williams
Definition and management of arterial hypertension in children and adolescents are uncertain, due to different positions of current guidelines. The European Society of Cardiology task-force, constituted by Associations and Councils with interest in arterial hypertension, has reviewed current literature and evidence, to produce a Consensus Document focused on aspects of hypertension in the age range
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Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects Cardiovasc. Res. (IF 13.081) Pub Date : 2022-07-27 Carla Carnovale, Cristiana Perrotta, Sara Baldelli, Dario Cattaneo, Cristina Montrasio, Silvia S Barbieri, Giulio Pompilio, Chiara Vantaggiato, Emilio Clementi, Marco Pozzi
A bidirectional relationship exists between hypertension and psychiatric disorders, including unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis, schizophrenia, mania, and dementia/cognitive decline. Repurposing of antihypertensive drugs to treat mental disorders is thus being explored. A systematic knowledge of the mechanisms of action and clinical consequences
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Molecular stratification of arrhythmogenic mechanisms in the Andersen Tawil Syndrome Cardiovasc. Res. (IF 13.081) Pub Date : 2022-07-27 Ana Isabel Moreno Manuel, Lilian K Gutiérrez, María Linarejos Vera Pedrosa, Francisco Miguel Cruz Uréndez, Francisco José Bermúdez Jiménez, Isabel Martínez Carrascoso, Patricia Sánchez Pérez, Álvaro Macías, José Jalife
Andersen Tawil Syndrome (ATS) is a rare inheritable disease associated with loss-of-function mutations in KCNJ2, the gene coding the strong inward rectifier potassium channel Kir2.1, which forms an essential membrane protein controlling cardiac excitability. ATS is usually marked by a triad of periodic paralysis, life-threatening cardiac arrhythmias and dysmorphic features, but its expression is variable
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AIMing 2 treat atherosclerosis Nat. Rev. Cardiol. (IF 49.421) Pub Date : 2022-07-26 Oliver Soehnlein, Alan R. Tall
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Donor Macrophages Modulate Rejection After Heart Transplantation Circulation (IF 39.918) Pub Date : 2022-07-26 Benjamin J. Kopecky, Hao Dun, Junedh M. Amrute, Chieh-Yu Lin, Andrea L. Bredemeyer, Yuriko Terada, Peter O. Bayguinov, Andrew L. Koenig, Christian C. Frye, James A.J. Fitzpatrick, Daniel Kreisel, Kory J. Lavine
BACKGROUND:Cellular rejection after heart transplantation imparts significant morbidity and mortality. Current immunosuppressive strategies are imperfect, target recipient T cells, and have adverse effects. The innate immune response plays an essential role in the recruitment and activation of T cells. Targeting the donor innate immune response would represent the earliest interventional opportunity
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Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults Circulation (IF 39.918) Pub Date : 2022-07-26 Sadiya S. Khan, Courtney Page, Daniel M. Wojdyla, Yosef Y. Schwartz, Philip Greenland, Michael J. Pencina
BACKGROUND:Understanding the predictive utility of previously derived polygenic risk scores (PRSs) for long-term risk of coronary heart disease (CHD) and its additive value beyond traditional risk factors can inform prevention strategies.METHODS:Data from adults 20 to 59 years of age who were free of CHD from the FOS (Framingham Offspring Study) and the ARIC (Atherosclerosis Risk in Communities) study
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Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2 Circulation (IF 39.918) Pub Date : 2022-07-26 Ling-Yue Sun, Yu-Yan Lyu, Heng-Yuan Zhang, Zhi Shen, Guan-Qiao Lin, Na Geng, Yu-Li Wang, Lin Huang, Ze-Hao Feng, Xiao Guo, Nan Lin, Song Ding, An-Cai Yuan, Lan Zhang, Kun Qian, Jun Pu
BACKGROUND:Metabolic disorder increases the risk of abdominal aortic aneurysm (AAA). NRs (nuclear hormone receptors) have been increasingly recognized as important regulators of cell metabolism. However, the role of NRs in AAA development remains largely unknown.METHODS:We analyzed the expression profile of the NR superfamily in AAA tissues and identified NR1D1 (NR subfamily 1 group D member 1) as
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Management of Atrial Fibrillation Across the Spectrum of Heart Failure With Preserved and Reduced Ejection Fraction Circulation (IF 39.918) Pub Date : 2022-07-25 Yogesh N.V. Reddy, Barry A. Borlaug, Bernard J. Gersh
Atrial fibrillation (AF) is the most common arrhythmia among patients with heart failure (HF), and HF is the most common cause of death for patients presenting with clinical AF. AF is frequently associated with pathological atrial myocardial dysfunction and remodeling, a triad that has been called atrial myopathy. AF can be the cause or consequence of clinical HF, and the directionality varies between
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Highlights From the Circulation Family of Journals Circulation (IF 39.918) Pub Date : 2022-07-25
Highlights from the June issues of the subspecialty journals span a variety of topics. The safety of pulsed field ablation, a novel technology for atrial fibrillation, is reported in Circulation: Arrhythmia and Electrophysiology. Associations of truncating variants in the desmosomal gene with arrhythmogenic right ventricular cardiomyopathy from the UK Biobank are analyzed in Circulation: Genomic and
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Correction to: Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure Circulation (IF 39.918) Pub Date : 2022-07-25
In the article by Borlaug et al, “Latent Pulmonary Vascular Disease May Alter the Response to Therapeutic Atrial Shunt Device in Heart Failure,” which published in the May 24, 2022, issue of the journal (Circulation.2022; 145:1592-1604. DOI: 10.1161/CIRCULATIONAHA.122.059486), a correction is needed. The disclosures of one the authors, Dr Scott Solomon, was inadvertently excluded from the disclosures
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Correction to: Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency Circulation (IF 39.918) Pub Date : 2022-07-25
In the article by Dou et al, “Oxidized Phospholipids Promote NETosis and Arterial Thrombosis in LNK(SH2B3) Deficiency,” which published in the December 14, 2021, issue of the journal (Circulation.2021;144:1940-1954. DOI: 10.1161/CIRCULATIONAHA.121.056414), a correction is needed. The disclosures of one the authors, Dr Pradeep Natarajan, was inadvertently excluded from the disclosures statement in the