-
Atheroprotection mediated by hepatic PPARα is linked to its anti-inflammatory, but not lipid-lowering, properties Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-06-12 Karina Huynh
A new study in science Translational Medicine demonstrates that the atheroprotective effects of PPARα agonists are associated with their anti-inflammatory properties rather than their lipid-lowering activity, highlighting the importance of targeting inflammation in managing the residual risk of cardiovascular disease
-
Reflections on Binary Thresholds for Hypercholesterolemia and Hypertension J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-11 Cian P. McCarthy, John W. McEvoy
Section snippets Funding Support and Author DisclosuresDr McCarthy is supported by a National Heart, Lung, And Blood Institute Career Development Award (K23HL167659); and has received consulting fees/honorarium from Roche Diagnostic, Abbott Laboratories, New Amsterdam Pharma, and Heartflow, Inc. Dr McEvoy has reported that he has no relationships relevant to the contents of this paper to disclose.
-
Patent Foramen Ovale and Dysarthria in a Man in His 60s JAMA Cardiol. (IF 14.8) Pub Date : 2025-06-11 Alpana Senapati, Yehia Saleh, Su Min Chang
This case report describes a diagnosis of patent foramen ovale in a man in his 60s presenting with stroke symptoms and multifocal infarcts on magnetic resonance imaging of the brain.
-
Institutional Variability in Processes of Care and Outcomes Among Patients With STEMI in the US JAMA Cardiol. (IF 14.8) Pub Date : 2025-06-11 Yasser M. Sammour, Safi U. Khan, Haoyun Hong, Jingyuan Wu, Alexander C. Fanaroff, Grant W. Reed, Remy Poudel, Kathie Thomas, Zhao Ni, Abhinav Goyal, Ajay J. Kirtane, Robert W. Yeh, W. Schuyler Jones, Sachin S. Goel, Wissam A. Jaber, Neal S. Kleiman
ImportancePercutaneous coronary intervention (PCI) is the criterion standard for acute ST-elevation myocardial infarction (STEMI). Achieving target first medical contact (FMC)–to-device time is a quality metric in STEMI care.ObjectivesTo describe site-level variability in achieving target FMC-to-device time (≤90 minutes for primary presentations to PCI-capable hospitals and ≤120 minutes for transfers)
-
Aortic Valve Replacement in Patients With Asymptomatic Severe Aortic Stenosis JAMA Cardiol. (IF 14.8) Pub Date : 2025-06-11 Graham S. Hillis, Gerry P. McCann, David E. Newby
This Viewpoint discusses recent calls for guideline revision regarding clinical management of asymptomatic severe aortic stenosis in the context of new data from 4 randomized trials.
-
A Patient With Cough, Palpitations, Dyspnea, and Chest Pain JAMA Cardiol. (IF 14.8) Pub Date : 2025-06-11 Yingying Wang, Yuchen Wang, Xuhong Geng
A man in his early 50s presented with recurrent episodes of cough, palpitations, shortness of breath, and exertional chest pain. What would you do next?
-
Temporal and Geographic Trends in the Treatment of Peripheral Arterial Disease Stratified by Race Among Medicare Beneficiaries JAMA Cardiol. (IF 14.8) Pub Date : 2025-06-11 Birgit Vogel, Katerina Dangas, Francesca Maria Di Muro, Samantha Sartori, Angelo Oliva, George Dangas, Prakash Krishnan, Harrison Yoon, Katherine Etter, Daniel Erim, Yuriy Pylypchuk, Rachel Keever, Roxana Mehran
ImportanceRacial disparities in the management of peripheral arterial disease (PAD) are well established. Analysis of the temporal trends and geographic variation in racial differences in the use of revascularization and major amputation may identify areas for targeted intervention.ObjectiveTo investigate differences in the treatment of PAD between Black and White patients over time and by US state
-
Heart Failure Care and Outcomes After Private Equity Acquisition of U.S. Hospitals J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Daniel Y. Johnson, Michael Liu, Victoria L. Bartlett, ZhaoNian Zheng, Andrew S. Oseran, Rishi K. Wadhera
-
Great debate: ablation of atrial fibrillation should be performed in patients with heart failure with reduced ejection fraction. Eur. Heart J. (IF 37.6) Pub Date : 2025-06-10 Cecilia Linde,Milton Packer,Johann Bauersachs
-
Exercise Mitigates Diabetic Cardiomyopathy by Suppressing Ferroptosis via N-Acetyltransferase 10. Circ. Res. (IF 16.5) Pub Date : 2025-06-10 Siman Shen,Aya Sugai-Munson,Xiao Xiao,Yajing Zhang,Jiayi Kang,Sumeet A Khetarpal,Eric R Jonas,Amrut V Ambardekar,Michael R Bristow,Haobo Li
-
C-C motif chemokine receptor 2 and phosphodiesterase type 5 inhibition in immune subphenotypes: a step toward personalized treatment for pulmonary arterial hypertension? Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-10 Christian J Goossen,Patrick J Pagano
-
Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve (BAV) caused by loss of primary cilia Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-10 Ahlam Alqahtani, Lorraine Eley, Jake Newton, Kimberley Macdonald, Chloe Connolly, Cindy Rodrigues-Cleto, Kristyna Neffeova, Leonor Lopez, Javier Arias, Christopher J Derrick, Mashael Alaradi, Hana Kolesova, Bill Chaudhry, Deborah J Henderson
Aims Bicuspid aortic valve (BAV), where two valve leaflets are found instead of the usual three, affects 1-2% of the general population and is associated with significant morbidity and mortality. Despite its frequency, the majority of cases remain unexplained. This is, at least in part, because there are two types of valve leaflet primordia: endocardial cushions and intercalated valve swellings (ICVS)
-
Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-10 Anuradha Kaistha, Sebnem Oc, Abel Martin Garrido, James C K Taylor, Maria Imaz, Matthew D Worssam, Anna Uryga, Mandy Grootaert, Kirsty Foote, Alison Finigan, Nichola Figg, Helle F Jørgensen, Martin Bennett
Aims Human atherosclerotic plaque cells display DNA damage that if left unrepaired can promote premature cell senescence. Vascular smooth muscle cells (VSMCs) predisposed to senescence promote atherogenesis and features of unstable plaques and increase neointima formation after injury. However, how premature VSMC senescence promotes vascular disease and its effects on VSMC phenotype are unknown. Methods
-
-
Contents J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09
Section snippets 10-Year and 30-Year Risks of Cardiovascular Disease in the U.S. Population 2239Kamil F. Faridi, Devesh Malik, Mohammed Essa, Huanhuan Yang, Erica S. Spatz, Harlan M. Krumholz, Yuan LuThis study used 2011-2020 National Health and Nutrition Examination Survey data and the American Heart Association PREVENT (Predicting Risk of Cardiovascular Disease Events) equations to estimate cardiovascular
-
10-Year and 30-Year Risks of Cardiovascular Disease in the U.S. Population J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Kamil F. Faridi, Devesh Malik, Mohammed Essa, Huanhuan Yang, Erica S. Spatz, Harlan M. Krumholz, Yuan Lu
-
Navigating the Long Road Ahead in Cardiovascular Disease Prevention Using the PREVENT Equations J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Sadiya S. Khan
Section snippets Funding Support and Author DisclosuresDr Khan has received research support from the National Heart, Lung, and Blood Institute and the American Heart Association.
-
Predicting Heart Failure Outcomes Using Patient-Reported Health Status: Real-World Validation of the KCCQ-12 J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Bassim R. El-Sabawi, Mohammed A. Al-Garadi, Bryan D. Steitz, Amy M. Perkins, Allison B. McCoy, Donald G. Sengstack, Robert A. Greevy, Emily H. Burnell, Kelly H. Schlendorf, JoAnn Lindenfeld, Lynne W. Stevenson, Deepak K. Gupta, John A. Spertus, Sean P. Collins, Michael E. Matheny, Justin M. Bachmann
-
Kansas City Cardiomyopathy Questionnaire: A Measure of Heart-Failure Risk, But Can it Improve Outcomes? J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Suzanne V. Arnold
Section snippets Next StepsAs noted earlier, it is not surprising that the KCCQ-12, when collected as a part of routine clinical care, is strongly associated with subsequent risk of death and heart failure hospitalization, independent of ejection fraction and other demographic and clinical factors. It was necessary to prove that this association remained consistent when the KCCQ was taken out of more
-
Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Results of an International Multicenter Prospective Registry J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Irene M. Lang, Philippe Brenot, Hélène Bouvaist, Elie Fadel, Xavier Jaïs, Michael M. Madani, Stefan Guth, Marcin Kurzyna, Gérald Simonneau, Christoph B. Wiedenroth, Ehtisham Mahmud, Hiroto Shimokawahara, Riyaz Bashir, Marion Delcroix, Robert Frantz, Christian Gerges, Laurent Godinas, Gustavo A. Heresi, Pavel Jansa, David P. Jenkins, Hiromi Matsubara
-
Pulmonary Balloon Angioplasty: A Call to Action J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Jane A. Leopold, Eric A. Secemsky
Section snippets Funding Support and Author DisclosuresDr Secemsky has received funding from National Institutes of Health/NHLBI K23HL150290; has received grants to institution from BD, Boston Scientific, Cook, Medtronic, and Philips; and has provided consulting for Abbott, Asahi, BD, Boston Scientific, Conavi, Cook, Cordis, Endovascular Engineering, Evident Vascular, Gore, InfraRedx, Medtronic, Philips
-
Long-Acting Factor XI Inhibition and Periprocedural Bleeding: An Analysis From AZALEA-TIMI 71 J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Siddharth M. Patel, Robert P. Giugliano, David A. Morrow, Sanobar Parkar, Hannah Shapiro, Bruce Hug, Julia F. Kuder, Erica L. Goodrich, Shih-Ann Chen, Shaun G. Goodman, Boyoung Joung, Robert G. Kiss, Wojciech Wojakowski, Jeffrey I. Weitz, Sabina A. Murphy, Stephen D. Wiviott, Daniel Bloomfield, Marc S. Sabatine, Christian T. Ruff
-
Perioperative Management of Patients Taking Factor XI Inhibitors: Small Steps Toward a Giant Leap J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 James D. Douketis, P. Gabriel Steg, Suzanne C. Cannegieter, Alex C. Spyropoulos
Section snippets Funding Support and Author DisclosuresDr Steg has received grant support from Amarin and Sanofi; has received honoraria from Amarin, Amgen, AstraZeneca, Bayer, Bristol Myers Squibb, Idorsia, Janssen, Lilly, Merck, Novartis, Novo Nordisk, Pfizer, and Sanofi; and has served as Chief Medical Officer for Bioquantis; and has served as Senior Associate Editor at Circulation. Dr Spyropoulos
-
Factor XI Inhibition for Prevention of Thromboembolism: Safe, But Efficacious? J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Behnood Bikdeli
Section snippets Funding Support and Author DisclosuresNo specific funds were sought or received for this manuscript. Outside the submitted work, Dr Bikdeli is supported by a Career Development Award from the American Heart Association and VIVA Physicians (#938814); was supported by the Scott Schoen and Nancy Adams IGNITE Award and is supported by the Mary Ann Tynan Research Scientist award from the
-
Re-Evaluating Recurrent Events in Heart Failure Trials: Patterns, Prognostic Implications, and Analytical Improvements J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Audinga-Dea Hazewinkel, John Gregson, Stuart J. Pocock, John McMurray, Scott D. Solomon, Brian Claggett, Milton Packer, Stefan D. Anker, João P. Ferreira, Kieran Docherty, Alasdair Henderson, Pardeep Jhund, Ulrica Wilderäng, David Wright
-
Embracing Uncertainty, Elevating Insight J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Harlan M. Krumholz
Section snippets Funding Support and Author DisclosuresIn the past 3 years, Dr Krumholz has received options for Element Science and Identifeye and payments from F-Prime for advisory roles; was a co-founder of and held equity in Hugo Health; is a co-founder of and holds equity in Refactor Health and ENSIGHT-AI; and is associated with research contracts through Yale University from Janssen, Kenvue,
-
Clinical Trial Perspective: Role and Interpretation of Responder Analyses Involving Patient-Reported Outcomes J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 John A. Spertus, Andrew J. Sauer, Suzanne V. Arnold, Philip G. Jones
Section snippets Establishing Clinically Meaningful Within-Patient Changes to Categorize ResponseWe agree with Southworth et al6 that patient anchors (eg, patient global assessments of severity and change) can help define clinically important changes, but not that CMWPCs should be re-estimated in each study. In the absence of accepted standards, individual trials develop anchors with unique questions
-
Less Heart Failure But No Improvement in Quality of Life in FINEARTS-HF: Why the Disconnect? J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Gad Cotter, Beth A. Davison, Deepak L. Bhatt
Section snippets Funding Support and Author DisclosuresDrs Cotter and Davison are employees of Momentum Research, which has received grants for research from the Heart Initiative, Corteria, Windtree, Echosens, and 4teen4. Dr Bhatt has served on the Advisory Board of Angiowave, Bayer, Boehringer Ingelheim, CellProthera, Cereno Scientific, E-Star Biotech, High Enroll, Janssen, Level Ex, McKinsey, Medscape
-
The 4 Longest Days J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Michelle M. Kittleson
No Abstract
-
Amara Yad Image: The Relationship Between the Pulmonary Trunk, Aortic Root, and Atrial Appendages J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Kalyanam Shivkumar
Section snippets Funding Support and Author DisclosuresThis work was supported by National Institutes of Health grant P01 HL164311 to Dr Shivkumar and the UCLA Amara-Yad Project. Dr Shivkumar is a consultant to Nference and Anumana.
-
The Effect of Aircraft Noise on Left Ventricular Remodeling J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Mi Zhou, Ming-jiao Liao, Li-xue Yin
No Abstract
-
Reply: The Effect of Aircraft Noise on Left Ventricular Remodeling J. Am. Coll. Cardiol. (IF 21.7) Pub Date : 2025-06-09 Constantin-Cristian Topriceanu, Xiangpu Gong, Anna L. Hansell, Gabriella Captur
No Abstract
-
Focus on trials: interventional cardiology, ischaemic heart disease, and long COVID. Eur. Heart J. (IF 37.6) Pub Date : 2025-06-09 Filippo Crea
-
Loss of Methyltransferase and Hypomethylated m6A Sarcomere Transcripts Leading to Early-Onset Dilated Cardiomyopathy. Circulation (IF 35.5) Pub Date : 2025-06-09 Sophie Marie Hand,Yi Zhao,Donna Li,Savanna Burke,Hee-Woong Lim,Jessie Yester,Vidu Garg,Federica Accornero,Xiao Li,Deqiang Li,Jihyun Jang
-
FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1. Circulation (IF 35.5) Pub Date : 2025-06-09 Changchen Xiao,Chao Wang,Jingyi Wang,Xianpeng Wu,Changle Ke,Jinliang Nan,Hao Ding,Yinghui Xu,Yanna Shi,Jing Zhao,Cheng Ni,Qingnian Liu,Jiamin Li,Shuyuan Sheng,Hua Chen,Jiayue Cai,Tonghui Zhao,Jinghai Chen,Qiming Sun,Bin Zhou,Jian'an Wang,Wei Zhu,Xinyang Hu
BACKGROUND Cardiac hypertrophy, as an important pathological change, contributes to heart failure. Recent studies indicate that the mitochondria-associated endoplasmic reticulum membranes (MAMs) play key roles in this pathological process. However, the molecular mechanism remains unclear. This study aims to elucidate the effects and mechanisms of MAM-resident FMO2 (flavin-containing monooxygenase 2)
-
Letter by Pan et al Regarding Article, "Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis". Circulation (IF 35.5) Pub Date : 2025-06-09 Daorong Pan,Wen Wu,Mingxing Chen
-
Response by Campo and Pavasini to Letter Regarding Article, "Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment-Elevation Myocardial Infarction: An Individual Patient Meta-Analysis". Circulation (IF 35.5) Pub Date : 2025-06-09 Gianluca Campo,Rita Pavasini
-
New Classification to Describe Clinical Presentation in Aortic Stenosis: Stable, Progressive, and Acute Valve Syndrome. Circulation (IF 35.5) Pub Date : 2025-06-09 Philippe Généreux,Brian R Lindman,Philippe Pibarot
-
Alcohol Use and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation (IF 35.5) Pub Date : 2025-06-09 Mariann R Piano,Gregory M Marcus,Dawn M Aycock,Jennifer Buckman,Chueh-Lung Hwang,Susanna C Larsson,Kenneth J Mukamal,Michael Roerecke,
Alcohol is one of the most commonly consumed substances in the world, exhibiting complex relationships with multiple aspects of cardiovascular health and disease. The majority of the research on the topic is observational and therefore prone to bias and confounding. The available evidence suggests no risk to possible risk reduction when alcohol is consumed in low amounts (such as no more than 1 to
-
Novel Mouse Model of Coronary Atherosclerosis With Myocardial Infarction: Insights Into Human CAD. Circ. Res. (IF 16.5) Pub Date : 2025-06-09 Hong Chen,Qing Wan,Jianfeng Yang,Haojie Rao,Chuansheng Xu,Pengfei Xu,Xuejian Yang,Hongyue Wang,Wei Feng,Liqing Wang,Magnus Bäck,Robert E Widdop,Feng Liu,Hong S Lu,Alan Daugherty,Shengshou Hu,Garret A FitzGerald,De-Pei Liu,Yu Huang,Weijun Jin,Miao Wang
BACKGROUND Coronary artery disease is a chronic and multifactorial disease with acute manifestations. Little is known about the concomitant impact of hypercholesterolemia and hypertension on the development of coronary atherosclerosis. METHODS ApoE and scavenger receptor B1, genes both associated with human hypercholesterolemia, were inactivated in mice by inserting a scavenger receptor B1 knockdown
-
Platelet-leukocyte aggregates in cardiovascular disease: prognostic significance and therapeutic potential Cardiovasc. Res. (IF 10.2) Pub Date : 2025-06-09 Jiaying Han, Conor J Bloxham, Kilian Kirmes, Giacomo Viggiani, Leonhard P Unkelbach, Moritz von Scheidt, Stephanie G Kühne, Isabell Bernlochner, Gianluigi Condorelli, Philip W J Raake, Dario Bongiovanni
Initially recognised for their role in vascular haemostasis, platelets are now understood to be critical regulators of inflammation and immune responses through complex interactions with immune cells. Key to this role is the formation of platelet-leukocyte aggregates (PLAs), with platelet-monocyte aggregates (PMAs) representing the most thoroughly studied type in cardiovascular disease. PLAs form through
-
Hypertension in Pregnancy Linked to Cerebral Small Vessel Disease 15 Years Later. Hypertension (IF 6.9) Pub Date : 2025-06-09 Rowina F Hussainali,Maria C Adank,Sander Lamballais,Meike W Vernooij,M Arfan Ikram,Eric A P Steegers,Eliza C Miller,Sarah Schalekamp-Timmermans
BACKGROUND Substantial evidence suggests an association between hypertensive disorders of pregnancy and long-term cerebrovascular health. We aimed to determine the associations between hypertensive disorders of pregnancy and markers of cerebral small vessel disease 15 years after pregnancy. METHODS This was a nested cohort study embedded in a population-based prospective cohort followed from early
-
Calcium Aspirin Preeclampsia Early Prevention and Response (CASPER) Trial in Blantyre, Malawi: A Double-Blinded Cluster Randomized Trial. Hypertension (IF 6.9) Pub Date : 2025-06-09 Memory M Ngwira,Angela Makris,Renuka Shanmugalingam,John L Mbotwa,Josiah Mayani,Luis A Gadama,Annemarie Hennessy
BACKGROUND Preeclampsia remains one of the major causes of maternal and neonatal mortality and morbidity, and yet it is uncertain whether aspirin combined with calcium would reduce the burden of preeclampsia in Malawian women, as elsewhere. This study assessed the efficacy of early low-dose aspirin in preventing in women given calcium to prevent preeclampsia/eclampsia in Blantyre, Malawi. METHODS This
-
Leadless and extravascular cardiac resynchronization therapy: the future for CRT? Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-06-06 Steven Niederer, Henry Chubb, Kenneth C. Bilchick, Christopher Aldo Rinaldi
-
A Nationwide Factorial Randomized Trial of Electronic Nudges to Patients with Chronic Kidney Disease and Their General Practices for Increasing Guideline-Directed Medical Therapy: The NUDGE-CKD Trial. Circulation (IF 35.5) Pub Date : 2025-06-07 Kristoffer Grundtvig Skaarup,Niklas Dyrby Johansen,Lisbet Brandi,Morten Kofod Lindhardt,Jesper N Bech,My Svensson,Tilde Kristensen,Anne Daugaard Thuesen,Majbritt Grønborg Knudsen,Jan Dominik Kampman,Mads Hornnum,Birgitte Ørts,Daniel Modin,Mats C H Lassen,Kira Hyldekær Janstrup,Brian L Claggett,Muthiah Vaduganathan,Ankeet S Bhatt,Harriette G C Van Spall,Jens Ulrik Stæhr Jensen,Faiez Zannad,Scott D Solomon
BACKGROUND Many individuals with chronic kidney disease (CKD) face considerable but modifiable risk of cardiovascular and renal outcomes due to suboptimal implementation of guideline-directed medical therapy (GDMT). We investigated whether electronic letter-based nudges delivered to individuals with CKD and their general practices could increase GDMT uptake. METHODS This was a nationwide 2x2 factorial
-
-
Cardiovascular involvement in glycogen storage diseases Nat. Rev. Cardiol. (IF 41.7) Pub Date : 2025-06-05 Tomàs Pinós, Richard M. Cubbon, Alfredo Santalla, Carmen Fiuza-Luces, Alejandro Santos-Lozano, Miguel A. Martín, Joaquín Arenas, Joachim Nielsen, Niels Ørtenblad, Alejandro Lucia
-
Great debate: Transcatheter aortic valve implantation should also be performed in non-surgical centres. Eur. Heart J. (IF 37.6) Pub Date : 2025-06-05 Miriam Compagnone,Stephan Windecker,Gianni Dall'Ara,Marcello Galvani,Simone Grotti,Matthias Siepe,Fabio Felice Tarantino,Daijiro Tomii,Marina Urena,Helmut Baumgartner
-
The double-edged sword of heart rate lowering in cardiovascular disease. Eur. Heart J. (IF 37.6) Pub Date : 2025-06-05 Franz H Messerli,Louis Hofstetter,Sripal Bangalore
-
Mastering percutaneous coronary intervention in calcified coronary lesions with optical coherence tomography: the path to optimal outcomes. Eur. Heart J. (IF 37.6) Pub Date : 2025-06-05 Marta Belmonte,Emanuele Barbato
-
Deficiency of the RNA-binding protein RBMS1 improves myocardial fibrosis and heart failure Eur. Heart J. (IF 37.6) Pub Date : 2025-06-05 Liangliang Li, Jiayu Guo, Jiayue Feng, Tianyu Li, Bingqian Xu, Wei Li, Na Yang, Weihang Ji, Shuping Zhuang, Yiding Geng, Bin Wang, Jinping Liu, Jian Sun, Yingying Guo, Ruoxuan Yang, Zhiwei Ning, Yan Wang, Qiudi Liu, Xiaomu Tian, Hongli Shan, Baofeng Yang, Haihai Liang
Background and Aims Previous studies have highlighted the significance of RNA-binding proteins and alternative splicing (AS) in the progression of complex diseases, but the specific involvement of AS in heart failure (HF) remains unclear. This study aimed to elucidate the role of RNA-binding motif single-stranded interacting protein 1 (RBMS1), an RNA-binding protein, in the development of HF by regulating
-
Optical coherence tomography- vs angiography-guided coronary stent implantation in calcified lesions: the ILUMIEN IV trial Eur. Heart J. (IF 37.6) Pub Date : 2025-06-05 Ziad A Ali, Doosup Shin, Rajesh Vijayvergiya, Atit A Gawalkar, Richard A Shlofmitz, Fernando Alfonso, Giuseppe Calligaris, Paolo Canova, Koshiro Sakai, Matthew J Price, David Leistner, Francesco Prati, Gary Mintz, Mitsuaki Matsumura, Robert J McGreevy, Robert W McNutt, Hong Nie, Jana Buccola, Ulf Landmesser, Akiko Maehara, Gregg W Stone
Background and Aims The large-scale, randomized ILUMIEN IV trial was examined to determine whether procedural guidance with optical coherence tomography (OCT) during percutaneous coronary intervention (PCI) of angiographically calcified lesions improves outcomes. Methods Patients with a single PCI target lesion were included in the present analysis. The presence of none, mild, moderate or severe lesion
-
High Dietary Phosphate Intake Induces Hypertension and Sympathetic Overactivation Through Central Fibroblast Growth Factor Receptor Signaling. Circulation (IF 35.5) Pub Date : 2025-06-05 Han-Kyul Kim,Ayumi Fukazawa,Scott A Smith,Masaki Mizuno,Beverly A Rothermel,Teppei Fujikawa,Marco Galvan,Laurent Gautron,Johanne V Pastor,Isabelle Carroll,Orson W Moe,Wanpen Vongpatanasin
BACKGROUND Recent studies have highlighted the deleterious role of high phosphate intake in hypertension by means of sympathetic overactivation, yet the underlying mechanisms remain unclear. Dietary phosphate loading triggers physiologic release of FGF23 (fibroblast growth factor-23) from the bone to maintain phosphate homeostasis. Both FGF23 and FGF receptors (FGFRs) are present in the central nervous
-
Neprilysin in Placental EVs as Culprits and Therapeutic Target for Preeclampsia. Circ. Res. (IF 16.5) Pub Date : 2025-06-05 Feng Dong,Yanqiao Zhang,Liya Yin
-
-
Intracellular pH Regulation in Ventricular Myocytes: Implications for Cardiac Health and Disease. Circ. Res. (IF 16.5) Pub Date : 2025-06-05 Alejandro Orlowski,Romina Alejandra Di Mattia,Ernesto Alejandro Aiello
Intracellular pH must be maintained within the physiological range (7.15-7.25) to ensure cellular homeostasis. In the heart, excitation-contraction coupling is closely dependent on intracellular pH because its proper regulation helps the correct management of intracellular Ca2+. In addition, it is important to know the spatial distribution of intracellular pH microdomains because it helps us to better
-
Ferroptosis in cardiovascular disease: regulatory mechanisms and therapeutic implications Eur. Heart J. (IF 37.6) Pub Date : 2025-06-04 Yiheng Zhao, Andreas Linkermann, Masafumi Takahashi, Qingguo Li, Xiang Zhou
Ferroptosis, an iron-dependent form of regulated cell death, has been identified as a key factor in the pathogenesis and progression of various cardiovascular diseases (CVDs). The molecular basis of ferroptosis involves lipid peroxidation, iron dysregulation, and antioxidant pathways. Accumulating evidence suggests that ferroptosis is associated with various CVDs, including atherosclerosis, myocardial
-
The Construction and Development of China's National Basic Science Center for Panvascular Interventional Complex Systems: Pioneering Device-Vessel Suitcordance Research. Eur. Heart J. (IF 37.6) Pub Date : 2025-06-04 Lingsen You,Li Shen,Junbo Ge
-
Burden of Cardiovascular Outcomes After SARS-CoV-2 Infection in South Korea and Japan: A Binational Population-Based Cohort Study. Circulation (IF 35.5) Pub Date : 2025-06-04 Sooji Lee,Seung Ha Hwang,Seoyoung Park,Yejun Son,Soeun Kim,Hyeon Jin Kim,Jaeyu Park,Hyesu Jo,Kyeongmin Lee,Jiyeon Oh,Min Seo Kim,Damiano Pizzol,Lee Smith,Jinseok Lee,Ho Geol Woo,Hayeon Lee,Dong Keon Yon
BACKGROUND Despite the significant global impact of the COVID-19 pandemic, limited studies have investigated the long-term cardiovascular sequelae of SARS-CoV-2 infection, particularly among Asian populations. This large-scale, population-based binational cohort study with long-term follow-up aimed to investigate the association between SARS-CoV-2 infection and the risk of cardiovascular events. METHODS
-
Aortic Aneurysm Risk and Somatic JAK2V617FVariation: Insights From a Multicenter, Population-Based Cardiovascular Screening Study. Circulation (IF 35.5) Pub Date : 2025-06-04 Lasse M Obel,Joachim S Skovbo,Axel C P Diederichsen,Mads Thomassen,Lasse Kjær,Morten K Larsen,Trine A Knudsen,Vibe Skov,Torben A Kruse,Mark Burton,Maja Dembic,Troels Wienecke,Maria Sabater-Lleal,Oke Gerke,Niels E Bruun,Christina Ellervik,Mette Brabrand,Flemming H Steffensen,Lars Frost,Jess Lambrechtsen,Martin Busk,Grazina Urbonaviciene,Kenneth Egstrup,Marek Karon,Søren Feddersen,Lars M Rasmussen,Hans
BACKGROUND The somatic JAK2V617F sequence variation, a key driver of myeloproliferative neoplasms, has been associated with increased risk of aortic aneurysms. This study aimed to explore associations between the JAK2V617F variant allele frequency (VAF) and ascending, descending, and abdominal aortic aneurysms. METHODS In the DANCAVAS I and II trials (Danish Cardiovascular Screening), 15 000 individuals