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Protein glycosylation in cardiovascular health and disease Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-18 John C. Chatham, Rakesh P. Patel
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Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population Hypertension (IF 8.3) Pub Date : 2024-03-18 Hayat Aljaibeji, Mahyar Heydarpour, Ana Maria Stanton, Jonathan S. Williams, Luminita H. Pojoga, Jose R. Romero, Gordon H. Williams
BACKGROUND:The mTOR (mechanistic target of rapamycin) is an essential regulator of fundamental biological processes. mTOR forms 2 distinct complexes, mTORC1 (mTOR complex 1) when it binds with RAPTOR (Regulatory-associated Protein of mTOR) and mTORC2 (mTOR complex 2) when it associates with RICTOR (Rapamycin-insesitive companion of mTOR). Due to the previous link between the mTOR pathway, aldosterone
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Identification of Circulating Plasma Proteins as a Mediator of Hypertension-Driven Cardiac Remodeling: A Mediation Mendelian Randomization Study Hypertension (IF 8.3) Pub Date : 2024-03-15 Yuanlong Hu, Lin Lin, Lei Zhang, Yuan Li, Xinhai Cui, Mengkai Lu, Zhiyuan Zhang, Xiuya Guan, Muxin Zhang, Jiaqi Hao, Xiaojie Wang, Jiaming Huan, Wenqing Yang, Chao Li, Yunlun Li
BACKGROUND:This study focused on circulating plasma protein profiles to identify mediators of hypertension-driven myocardial remodeling and heart failure.METHODS:A Mendelian randomization design was used to investigate the causal impact of systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure on 82 cardiac magnetic resonance traits and heart failure risk. Mediation analyses
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Cytokines, C-Reactive Protein, and Risk of Incident Hypertension in the REGARDS Study Hypertension (IF 8.3) Pub Date : 2024-03-15 Timothy B. Plante, Stephen P. Juraschek, George Howard, Virginia J. Howard, Russell P. Tracy, Nels C. Olson, Suzanne E. Judd, Debora Kamin Mukaz, Neil A. Zakai, D. Leann Long, Mary Cushman
BACKGROUND:Hypertension is a highly prevalent cardiovascular disease risk factor that may be related to inflammation. Whether adverse levels of specific inflammatory cytokines relate to hypertension is unknown. The present study sought to determine whether higher levels of IL (interleukin)-1β, IL-6, TNF (tumor necrosis factor)-α, IFN (interferon)-γ, IL-17A, and CRP (C-reactive protein) are associated
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Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome Circ. Res. (IF 20.1) Pub Date : 2024-03-18 Francisco M. Cruz, Álvaro Macías, Ana I. Moreno-Manuel, Lilian K. Gutiérrez, María Linarejos Vera-Pedrosa, Isabel Martínez-Carrascoso, Patricia Sánchez Pérez, Juan Manuel Ruiz Robles, Francisco J. Bermúdez-Jiménez, Aitor Díaz-Agustín, Fernando Martínez de Benito, Salvador Arias-Santiago, Aitana Braza-Boils, Mercedes Martín-Martínez, Marta Gutierrez-Rodríguez, Juan A. Bernal, Esther Zorio, Juan Jiménez-Jaimez
BACKGROUND:Andersen-Tawil syndrome type 1 is a rare heritable disease caused by mutations in the gene coding the strong inwardly rectifying K+ channel Kir2.1. The extracellular Cys (cysteine)122-to-Cys154 disulfide bond in the channel structure is crucial for proper folding but has not been associated with correct channel function at the membrane. We evaluated whether a human mutation at the Cys122-to-Cys154
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Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth Circulation (IF 37.8) Pub Date : 2024-03-15 Tal Caller, Itai Rotem, Olga Shaihov-Teper, Daria Lendengolts, Yeshai Schary, Ruty Shai, Efrat Glick-Saar, Dan Dominissini, Menachem Motiei, Idan Katzir, Rachela Popovtzer, Merav Nahmoud, Alex Boomgarden, Crislyn D’Souza-Schorey, Nili Naftali-Shani, Jonathan Leor
BACKGROUND:Myocardial infarction (MI) and heart failure are associated with an increased incidence of cancer. However, the mechanism is complex and unclear. Here, we aimed to test our hypothesis that cardiac small extracellular vesicles (sEVs), particularly cardiac mesenchymal stromal cell–derived sEVs (cMSC-sEVs), contribute to the link between post-MI left ventricular dysfunction (LVD) and cancer
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Association of Blood Pressure With Brain White Matter Microstructural Integrity Assessed With MRI Diffusion Tensor Imaging in Healthy Young Adults Hypertension (IF 8.3) Pub Date : 2024-03-15 Junyeon Won, Pauline Maillard, Kevin Shan, John Ashely, Danilo Cardim, David C. Zhu, Rong Zhang
BACKGROUND:High blood pressure (BP) in middle-aged and older adults is associated with a brain white matter (WM) microstructural abnormality. However, little evidence is available in healthy young adults. We investigated the associations between high BP and WM microstructural integrity in young adults.METHODS:This study included 1015 healthy young adults (542 female, 22–37 years) from the Human Connectome
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Therapeutic Inertia With Initial Low-Dose Quadruple Combination Therapy for Hypertension: Results From the QUARTET Trial Hypertension (IF 8.3) Pub Date : 2024-03-13 Nelson Wang, Amy von Huben, Simone Marschner, Mark Nelson, Janis M. Nolde, Markus Schlaich, Gemma Figtree, Graham Hillis, Tim Usherwood, Christopher Reid, John Chalmers, Shirley Jansen, Emily R. Atkins, Laurent Billot, Clara Chow, Anthony Rodgers, On behalf of the QUARTET Investigators
BACKGROUND:Low-dose combinations are a promising intervention for improving blood pressure (BP) control but their effects on therapeutic inertia are uncertain.METHODS:Analysis of 591 patients randomized to an ultra-low-dose quadruple pill or initial monotherapy. The episode of therapeutic inertia was defined as a patient visit with a BP of >140/90 mm Hg without intensification of antihypertensive treatment
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Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease Circ. Res. (IF 20.1) Pub Date : 2024-03-14 Eng H. Lo, Frank M. Faraci
All living organisms on Earth demonstrate rhythms in biological function, which are approximately tied to the 24-hour cycle of a single day and night. The term diurnal is commonly used to describe events that occur during the day. For example, a diurnal species is the one that is mainly active during the daylight. In contrast, the term circadian refers to a rhythm that has a period of ≈24 hours but
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Circadian Clock and Hypoxia Circ. Res. (IF 20.1) Pub Date : 2024-03-14 Francesca Sartor, Borja Ferrero-Bordera, Jeffrey Haspel, Markus Sperandio, Paul M. Holloway, Martha Merrow
The timing of life on Earth is remarkable: between individuals of the same species, a highly similar temporal pattern is observed, with shared periods of activity and inactivity each day. At the individual level, this means that over the course of a single day, a person alternates between two states. They are either upright, active, and communicative or they lie down in a state of (un)consciousness
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Circadian and Diurnal Regulation of Cerebral Blood Flow Circ. Res. (IF 20.1) Pub Date : 2024-03-14 Alastair J.S. Webb, Elizabeth B. Klerman, Emiri T. Mandeville
Circadian and diurnal variation in cerebral blood flow directly contributes to the diurnal variation in the risk of stroke, either through factors that trigger stroke or due to impaired compensatory mechanisms. Cerebral blood flow results from the integration of systemic hemodynamics, including heart rate, cardiac output, and blood pressure, with cerebrovascular regulatory mechanisms, including cerebrovascular
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Imaging cAMP nanodomains in human iPSC-derived cardiomyocytes Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-15 Camille Charrière
In this Tools of the Trade article, Charrière describes the FluoStep FRET-based biosensor used for high-resolution imaging of cAMP nanodomains that are involved in intracellular signalling in cardiomyocytes.
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Novel cardiovascular therapeutics and the risk of financial toxicity Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-14 Alexander H. Gunn, Akshay Pendyal
Novel cardiovascular therapeutics have the potential to improve health outcomes, but financial toxicity from high out-of-pocket costs can limit the reach of these medications and worsen existing health disparities. Understanding the phenomenon of financial toxicity in treating cardiovascular disease is crucial to achieving health equity.
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Cardiovascular Management of Patients Undergoing Hematopoietic Stem Cell Transplantation: From Pretransplantation to Survivorship: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-03-11 Salim S. Hayek, Vlad G. Zaha, Carmel Bogle, Anita Deswal, Amelia Langston, Seth Rotz, Alexi Vasbinder, Eric Yang, Tochukwu Okwuosa, on behalf of the American Heart Association Cardio-Oncology Committee of the Council on Clinical Cardiology and Council on Genomic and Precision Medicine, and the Council on Cardiovascular and Stroke Nursing
Hematopoietic stem cell transplantation can cure various disorders but poses cardiovascular risks, especially for elderly patients and those with cardiovascular diseases. Cardiovascular evaluations are crucial in pretransplantation assessments, but guidelines are lacking. This American Heart Association scientific statement summarizes the data on transplantation-related complications and provides guidance
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Anderson–Fabry disease management: role of the cardiologist Eur. Heart J. (IF 39.3) Pub Date : 2024-03-15 Maurizio Pieroni, Mehdi Namdar, Iacopo Olivotto, Robert J Desnick
Anderson–Fabry disease (AFD) is a lysosomal storage disorder characterized by glycolipid accumulation in cardiac cells, associated with a peculiar form of hypertrophic cardiomyopathy (HCM). Up to 1% of patients with a diagnosis of HCM indeed have AFD. With the availability of targeted therapies for sarcomeric HCM and its genocopies, a timely differential diagnosis is essential. Specifically, the therapeutic
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Recombinant human soluble domain of CD39L3 and ticagrelor: cardioprotective effects in experimental myocardial infarction Eur. Heart J. (IF 39.3) Pub Date : 2024-03-15 Gemma Vilahur, Monika Radike, Pablo Sutelman, Soumaya Ben-Aicha, Manuel Gutiérrez, Laura Casaní, Daniel Hovdal, Emily L Ongstad, Anders Gabrielsen, Alberto Hidalgo, Ola Fjellström, Leif Carlsson, Lina Badimon
Background and Aims The ecto–nucleoside triphosphate diphosphohydrolases of the CD39 family degrade ATP and ADP into AMP, which is converted into adenosine by the extracellular CD73/ecto-5-nucleotidase. This pathway has been explored in antithrombotic treatments but little in myocardial protection. We have investigated whether the administration of solCD39L3 (AZD3366) confers additional cardioprotection
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Modelling pre-eclampsia and its cardiovascular effects Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-13 Sol Olivera, Delyth Graham
In this Tools of the Trade article, Olivera describes a rat model of pre-elampsia that has been instrumental for investigating potential long-term cardiovascular effects in offspring.
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Rationale of the Inclusion of β-Blockers Among Major Antihypertensive Drugs in the 2023 European Society of Hypertension Guidelines Hypertension (IF 8.3) Pub Date : 2024-03-13 Giuseppe Mancia, Mattias Brunström, Michel Burnier, Guido Grassi, Andrzej Januszewicz, Sverre E. Kjeldsen, Maria L. Muiesan, Costas Thomopoulos, Konstantinos Tsioufis, Reinhold Kreutz
We address the reasons why, unlike other guidelines, in the 2023 guidelines of the European Society of Hypertension β-blockers (BBs) have been regarded as major drugs for the treatment of hypertension, at the same level as diuretics, calcium channel blockers, and blockers of the renin-angiotensin system. We argue that BBs, (1) reduce blood pressure (the main factor responsible for treatment-related
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Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting in Patients With Left Main Disease With or Without Diabetes: Findings From a Pooled Analysis of 4 Randomized Clinical Trials Circulation (IF 37.8) Pub Date : 2024-03-11 Prakriti Gaba, Joseph F. Sabik, Sabina A. Murphy, Andrea Bellavia, Patrick T. O’Gara, Peter K. Smith, Patrick W. Serruys, A. Pieter Kappetein, Seung-Jung Park, Duk-Woo Park, Evald H. Christiansen, Niels R. Holm, Per H. Nielsen, Marc S. Sabatine, Gregg W. Stone, Brian A. Bergmark
BACKGROUND:Diabetes may be associated with differential outcomes in patients undergoing left main coronary revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The aim of this study was to investigate outcomes in patients with left main disease with and without diabetes undergoing PCI versus CABG.METHODS:Individual patient data were pooled from
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An epigenome editing approach induces durable silencing of Pcsk9 Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-13 Irene Fernández-Ruiz
A new approach to modify the epigenome can lead to durable silencing of Pcsk9 in mice, thereby reducing plasma LDL-cholesterol levels, according to a study published in Nature.
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Tackling inflammation in atherosclerosis Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-12 Mohsen Shoaran, Pasquale Maffia
Shoaran and Maffia recount how our understanding of the role of inflammation in atherosclerosis has evolved and highlight the study by Göran Hansson and colleagues that provided the first hint of the involvement of the adaptive immune response in atherosclerosis.
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Correction to: 2023 Scientific Sessions Abstract 18987 Circulation (IF 37.8) Pub Date : 2024-03-11
In the 2023 Scientific Sessions abstract by Umrani et al, “Abstract 18987: A 10-Year Contemporary Analysis of Outcomes of Patients With Amyloidosis and VT Underdoing Ventricular Tachycardia (VT) Ablation,” which published on November 6, 2023 (Circulation. 2023;148:A18987. DOI: 10.1161/circ.148.suppl_1.18987), a correction is needed. In the author byline, author “Yaser Khallid” has been updated to read
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Antiarrhythmic Drug Therapy: Where Do We Go From Here? Circulation (IF 37.8) Pub Date : 2024-03-11 Peter R. Kowey, Gerald V. Naccarelli
Most sufferers with heart disease cannot be cured. The purpose of intelligent care is the prolongation of life, the diminution of suffering, and the increase in the mental and physical efficiency of the patient. — Samuel Levine, Clinical Heart Disease Fourth Edition, Saunders, 1951 Antiarrhythmic drugs have been and will remain the mainstay of the chronic therapy of patients who have cardiac arrhythmias
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Correction to: Development and Validation of the American Heart Association’s PREVENT Equations Circulation (IF 37.8) Pub Date : 2024-03-11
In the article by Khan et al, “Development and Validation of the American Heart Association’s PREVENT Equations,” which appeared in the February 6, 2024, issue of the journal (Circulation. 2024;149:430–449. DOI: 10.1161/CIRCULATIONAHA.123.067626), a correction is needed. On page 433, the year range in the following sentence was updated from 2015–2020 to 2015–2019, to read, “The SDI was calculated at
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Correction to: 2023 Scientific Sessions Abstract 18918 Circulation (IF 37.8) Pub Date : 2024-03-11
In the 2023 Scientific Sessions abstract by Umrani et al, “Abstract 18918: Outcomes of Patients With Transcatheter Aortic Valve Replacement (TAVR) and Cardiac Resynchronization Therapy (CRT): A Retrospective Analysis,” which published on November 6, 2023 (Circulation. 2023;148:A18918. DOI: 10.1161/circ.148.suppl_1.18918), a correction is needed. In the author byline, Yaser Khalid has been added as
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Transcatheter Myotomy to Reduce Left Ventricular Outflow Obstruction J. Am. Coll. Cardiol. (IF 24.0) Pub Date : 2024-03-11 Adam B. Greenbaum MD, Hiroki A. Ueyama MD, Patrick T. Gleason MD, Jaffar M. Khan PhD BM BCh, Christopher G. Bruce MB ChB, Rim N. Halaby MD, Toby Rogers PhD BM BCh, George S. Hanzel MD, Joe X. Xie MD, Isida Byku MD, Robert A. Guyton MD, Kendra J. Grubb MD, John C. Lisko MD, Nikoloz Shekiladze MD, Errol K. Inci MD, Elizabeth A. Grier MD, Gaetano Paone MD, James M. McCabe MD, Robert J. Lederman MD, Vasilis
Left ventricular outflow tract (LVOT) obstruction is a source of morbidity in hypertrophic cardiomyopathy (HCM) and a life-threatening complication of transcatheter mitral valve replacement (TMVR) and transcatheter aortic valve replacement (TAVR). Available surgical and transcatheter approaches are limited by high surgical risk, unsuitable septal perforators, and heart block requiring permanent pacemakers
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18F-FDG PET/CT and Radiolabeled Leukocyte SPECT/CT Imaging for the Evaluation of Cardiovascular Infection in the Multimodality Context: ASNC Imaging Indications (ASNC I2) Series Expert Consensus Recommendations From ASNC, AATS, ACC, AHA, ASE, EANM, HRS, IDSA, SCCT, SNMMI, and STS JACC Cardiovasc. Imaging (IF 14.0) Pub Date : 2024-03-11 Jamieson M. Bourque, Ulrika Birgersdotter-Green, Paco E. Bravo, Ricardo P.J. Budde, Wengen Chen, Vivian H. Chu, Vasken Dilsizian, Paola Anna Erba, Cesia Gallegos Kattan, Gilbert Habib, Fabien Hyafil, Yiu Ming Khor, Jaimie Manlucu, Pamela Kay Mason, Edward J. Miller, Marc R. Moon, Matthew W. Parker, Gosta Pettersson, Robert D. Schaller, Riemer H.J.A. Slart, Jordan B. Strom, Bruce L. Wilkoff, Adam Williams
This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I) series to assess the role of radionuclide imaging in the multimodality context for the evaluation of complex systemic diseases with multi-societal involvement including pertinent disciplines. A rigorous modified Delphi approach was used
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Association of Blood Pressure With Brain Ages: A Cohort Study of Gray and White Matter Aging Discrepancy in Mid-to-Older Adults From UK Biobank Hypertension (IF 8.3) Pub Date : 2024-03-11 Jing Du, Yuangang Pan, Jiyang Jiang, Yue Liu, Ben C.P. Lam, Aletta E. Schutte, Ivor W. Tsang, Perminder S. Sachdev, Wei Wen
BACKGROUND:Gray matter (GM) and white matter (WM) impairments are both associated with raised blood pressure (BP), although whether elevated BP is differentially associated with the GM and WM aging process remains inadequately examined.METHODS:We included 37 327 participants with diffusion-weighted imaging (DWI) and 39 630 participants with T1-weighted scans from UK Biobank. BP was classified into
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Sex-related similarities and differences in responses to heart failure therapies Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-08 Janice Y. Chyou, Hailun Qin, Javed Butler, Adriaan A. Voors, Carolyn S. P. Lam
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Cardiac memory: a phenomenon with important clinical implications Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-07 Rebecca J. Gilchrist
Rebecca Gilchrist discusses the study that demonstrated the long-term modulation of ventricular repolarization by the sequence of electrical activation in the human heart and established the concept of cardiac memory.
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Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis Circ. Res. (IF 20.1) Pub Date : 2024-03-08 Onorina Laura Manzo, Jasmine Nour, Linda Sasset, Alice Marino, Luisa Rubinelli, Sailesh Palikhe, Martina Smimmo, Yang Hu, Maria Rosaria Bucci, Alain Borczuk, Olivier Elemento, Julie K. Freed, Giuseppe Danilo Norata, Annarita Di Lorenzo
Background:Growing evidence correlated changes in bioactive sphingolipids, particularly S1P (sphingosine-1-phosphate) and ceramides, with coronary artery diseases. Furthermore, specific plasma ceramide species can predict major cardiovascular events. Dysfunction of the endothelium lining lesion-prone areas plays a pivotal role in atherosclerosis. Yet, how sphingolipid metabolism and signaling change
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CNP Ameliorates Macrophage Inflammatory Response and Atherosclerosis Circ. Res. (IF 20.1) Pub Date : 2024-03-08 Qiankun Bao, Bangying Zhang, Lu Zhou, Qian Yang, Xiaofeng Mu, Xing Liu, Shiying Zhang, Meng Yuan, Yue Zhang, Jingjin Che, Wen Wei, Tong Liu, Guangping Li, Jinlong He
BACKGROUND:CNP (C-type natriuretic peptide), an endogenous short peptide in the natriuretic peptide family, has emerged as an important regulator to govern vascular homeostasis. However, its role in the development of atherosclerosis remains unclear. This study aimed to investigate the impact of CNP on the progression of atherosclerotic plaques and elucidate its underlying mechanisms.METHODS:Plasma
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Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function Circ. Res. (IF 20.1) Pub Date : 2024-03-08 Chen Li, Sara K. Ture, Benjamin Nieves-Lopez, Sara K. Blick-Nitko, Preeti Maurya, Alison C. Livada, Tyler J. Stahl, Minsoo Kim, Anthony P. Pietropaoli, Craig N. Morrell
BACKGROUND:While platelets have well-studied hemostatic functions, platelets are immune cells that circulate at the interface between the vascular wall and white blood cells. The physiological implications of these constant transient interactions are poorly understood. Activated platelets induce and amplify immune responses, but platelets may also maintain immune homeostasis in healthy conditions,
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SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits Cardiovasc. Res. (IF 10.8) Pub Date : 2024-03-08 Alberto Preda, Fabrizio Montecucco, Federico Carbone, Giovanni G Camici, Thomas F Lüscher, Simon Kraler, Luca Liberale
An increasing number of individuals is at high risk of type 2 diabetes (T2D) and its cardiovascular complications, including heart failure (HF), chronic kidney disease (CKD), and premature death. The sodium-glucose cotransporter-2 (SGLT2) protein sits in the proximal tubule of human nephrons to regulate glucose reabsorption, and its inhibition by gliflozins represents the cornerstone of contemporary
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Smooth muscle cell-specific MMP-3 deletion reduces osteogenic transformation and medial artery calcification Cardiovasc. Res. (IF 10.8) Pub Date : 2024-03-08 Yangzhouyun Xie, Tonghui Lin, Ying Jin, Alexa G Berezowitz, Xue-Lin Wang, Jinny Lu, Yujun Cai, Raul J Guzman
Aims Vascular calcification is highly prevalent in atherosclerosis, diabetes, and chronic kidney disease. It is associated with increased morbidity and mortality in patients with cardiovascular disease. Matrix metalloproteinase 3 (MMP-3), also known as stromelysin-1, is part of the large matrix metalloproteinase family. It can degrade extracellular matrix components of the arterial wall including elastin
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Status and Future Directions for Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Disease With and Without Pulmonary Hypertension: A Scientific Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-03-07 Vikas Aggarwal, Jay Giri, Scott H. Visovatti, Ehtisham Mahmud, Hiromi Matsubara, Michael Madani, Frances Rogers, Deepa Gopalan, Kenneth Rosenfield, Vallerie V. McLaughlin, on behalf of the American Heart Association Council on Clinical Cardiology, Council on Peripheral Vascular Disease, Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation, and Council on Cardiovascular and Stroke
Balloon pulmonary angioplasty continues to gain traction as a treatment option for patients with chronic thromboembolic pulmonary disease with and without pulmonary hypertension. Recent European Society of Cardiology guidelines on pulmonary hypertension now give balloon pulmonary angioplasty a Class 1 recommendation for inoperable and residual chronic thromboembolic pulmonary hypertension. Not surprisingly
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AI-Defined Cardiac Anatomy Improves Risk Stratification of Hybrid Perfusion Imaging JACC Cardiovasc. Imaging (IF 14.0) Pub Date : 2024-03-06 Robert J.H. Miller MD, Aakash Shanbhag MSc, Aditya Killekar MSc, Mark Lemley BS, Bryan Bednarski MSc, Paul B. Kavanagh MS, Attila Feher MD PhD, Edward J. Miller MD PhD, Timothy Bateman MD, Valerie Builoff BS, Joanna X. Liang BA, David E. Newby MD PhD, Damini Dey PhD, Daniel S. Berman MD, Piotr J. Slomka PhD
Computed tomography attenuation correction (CTAC) improves perfusion quantification of hybrid myocardial perfusion imaging by correcting for attenuation artifacts. Artificial intelligence (AI) can automatically measure coronary artery calcium (CAC) from CTAC to improve risk prediction but could potentially derive additional anatomic features. The authors evaluated AI-based derivation of cardiac anatomy
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Associations of Proteomics With Hypertension and Systolic Blood Pressure: KORA S4/F4/FF4 and KORA-Age1/Age2 Cohort Studies Hypertension (IF 8.3) Pub Date : 2024-03-06 Jie-sheng Lin, Agnese Petrera, Stefanie M. Hauck, Christian L. Müller, Annette Peters, Barbara Thorand
BACKGROUND:Hypertension, a complex condition, is primarily defined based on blood pressure readings without involving its pathophysiological mechanisms. We aimed to identify biomarkers through a proteomic approach, thereby enhancing the future definition of hypertension with insights into its molecular mechanisms.METHODS:The discovery analysis included 1560 participants, aged 55 to 74 years at baseline
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Ovariectomy-Induced Arterial Stiffening Differs From Vascular Aging and Is Reversed by GPER Activation Hypertension (IF 8.3) Pub Date : 2024-03-06 Isabella M. Kilanowski-Doroh, Alexandra B. McNally, Tristen Wong, Bruna Visniauskas, Sophia A. Blessinger, Ariane Imulinde Sugi, Chase Richard, Zaidmara Diaz, Alec Horton, Christopher A. Natale, Benard O. Ogola, Sarah H. Lindsey
BACKGROUND:Arterial stiffness is a cardiovascular risk factor and dramatically increases as women transition through menopause. The current study assessed whether a mouse model of menopause increases arterial stiffness in a similar manner to aging and whether activation of the G-protein–coupled estrogen receptor could reverse stiffness.METHODS:Female C57Bl/6J mice were ovariectomized at 10 weeks of
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Heart failure pharmacotherapy and cancer: pathways and pre-clinical/clinical evidence Eur. Heart J. (IF 39.3) Pub Date : 2024-03-05 Nabil V Sayour, Ágnes M Paál, Pietro Ameri, Wouter C Meijers, Giorgio Minotti, Ioanna Andreadou, Antonella Lombardo, Massimiliano Camilli, Heinz Drexel, Erik Lerkevang Grove, Gheorghe Andrei Dan, Andreea Ivanescu, Anne Grete Semb, Gianluigi Savarese, Dobromir Dobrev, Filippo Crea, Juan-Carlos Kaski, Rudolf A de Boer, Péter Ferdinandy, Zoltán V Varga
Heart failure (HF) patients have a significantly higher risk of new-onset cancer and cancer-associated mortality, compared to subjects free of HF. While both the prevention and treatment of new-onset HF in patients with cancer have been investigated extensively, less is known about the prevention and treatment of new-onset cancer in patients with HF, and whether and how guideline-directed medical therapy
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Atrial secondary tricuspid regurgitation: pathophysiology, definition, diagnosis, and treatment Eur. Heart J. (IF 39.3) Pub Date : 2024-03-05 Denisa Muraru, Luigi P Badano, Rebecca T Hahn, Roberto M Lang, Victoria Delgado, Nina C Wunderlich, Erwan Donal, Maurizio Taramasso, Alison Duncan, Philipp Lurz, Tom De Potter, José L Zamorano Gómez, Jeroen J Bax, Ralph Stephan von Bardeleben, Maurice Enriquez-Sarano, Francesco Maisano, Fabien Praz, Marta Sitges
Atrial secondary tricuspid regurgitation (A-STR) is a distinct phenotype of secondary tricuspid regurgitation with predominant dilation of the right atrium and normal right and left ventricular function. Atrial secondary tricuspid regurgitation occurs most commonly in elderly women with atrial fibrillation and in heart failure with preserved ejection fraction in sinus rhythm. In A-STR, the main mechanism
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Characterization of Vascular Niche in Systemic Sclerosis by Spatial Proteomics Circ. Res. (IF 20.1) Pub Date : 2024-03-05 Aleix Rius Rigau, Yi-Nan Li, Alexandru-Emil Matei, Andrea-Hermina Györfi, Peter-Martin Bruch, Sarah Koziel, Veda Devakumar, Armando Gabrielli, Alexander Kreuter, Jiucun Wang, Sascha Dietrich, Georg Schett, Jörg H.W. Distler, Minrui Liang
BACKGROUND:Systemic sclerosis (SSc) is a connective tissue disease that can serve as a model to study vascular changes in response to inflammation, autoimmunity, and fibrotic remodeling. Although microvascular changes are the earliest histopathologic manifestation of SSc, the vascular pathophysiology remains poorly understood.OBJECTIVE:We applied spatial proteomic approaches to deconvolute the heterogeneity
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The electrophysiologic effects of KCNQ1 extend beyond expression of IKs: evidence from genetic and pharmacologic block Cardiovasc. Res. (IF 10.8) Pub Date : 2024-03-05 Yuko Wada, Lili Wang, Lynn D Hall, Tao Yang, Laura L Short, Joseph F Solus, Andrew M Glazer, Dan M Roden
Aims While variants in KCNQ1 are the commonest cause of the congenital long QT syndrome, we and others find only a small IKs in cardiomyocytes from human induced pluripotent stem cells (iPSC-CMs) or human ventricular myocytes. Methods and Results We studied population control iPSC-CMs and iPSC-CMs from a patient with Jervell and Lange-Nielsen (JLN) syndrome due to compound heterozygous loss of function
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Metabolic product of excess niacin is linked to increased risk of cardiovascular events Nat. Rev. Cardiol. (IF 49.6) Pub Date : 2024-03-04 Gregory B. Lim
A metabolic product of excess niacin promotes vascular inflammation in preclinical models and is associated with increased rates of major adverse cardiovascular events in humans.
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Toward Heart-Healthy and Sustainable Cities: A Policy Statement From the American Heart Association Circulation (IF 37.8) Pub Date : 2024-03-04 Sanjay Rajagopalan, Anu Ramaswami, Aruni Bhatnagar, Robert D. Brook, Mark Fenton, Christopher Gardner, Roni Neff, Armistead G. Russell, Karen C. Seto, Laurie P. Whitsel, on behalf of the American Heart Association Council on Hypertension, Council on Lifestyle and Cardiometabolic Health, Council on Peripheral Vascular Disease, Council on Lifelong Congenital Heart Disease and Heart Health in the Young
Nearly 56% of the global population lives in cities, with this number expected to increase to 6.6 billion or >70% of the world’s population by 2050. Given that cardiometabolic diseases are the leading causes of morbidity and mortality in people living in urban areas, transforming cities and urban provisioning systems (or urban systems) toward health, equity, and economic productivity can enable the
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Ultrasound Shear Wave Elastography in Cardiology JACC Cardiovasc. Imaging (IF 14.0) Pub Date : 2024-03-04 Annette Caenen, Stéphanie Bézy, Mathieu Pernot, Kathryn R. Nightingale, Hendrik J. Vos, Jens-Uwe Voigt, Patrick Segers, Jan D’hooge
The advent of high–frame rate imaging in ultrasound allowed the development of shear wave elastography as a noninvasive alternative for myocardial stiffness assessment. It measures mechanical waves propagating along the cardiac wall with speeds that are related to stiffness. The use of cardiac shear wave elastography in clinical studies is increasing, but a proper understanding of the different factors
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Leadless pacemakers at 5-year follow-up: the Micra transcatheter pacing system post-approval registry Eur. Heart J. (IF 39.3) Pub Date : 2024-03-01 Mikhael F El-Chami, Christophe Garweg, Nicolas Clementy, Faisal Al-Samadi, Saverio Iacopino, Jose Luis Martinez-Sande, Paul R Roberts, Claudio Tondo, Jens Brock Johansen, Xavier Vinolas-Prat, Yong-Mei Cha, Eric Grubman, Pierre Bordachar, Kurt Stromberg, Dedra H Fagan, Jonathan P Piccini
Background and Aims Prior reports have demonstrated a favourable safety and efficacy profile of the Micra leadless pacemaker over mid-term follow-up; however, long-term outcomes in real-world clinical practice remain unknown. Updated performance of the Micra VR leadless pacemaker through five years from the worldwide post-approval registry (PAR) was assessed. Methods All Micra PAR patients undergoing
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Transcatheter treatment of the tricuspid valve: current status and perspectives Eur. Heart J. (IF 39.3) Pub Date : 2024-03-01 Francesco Maisano, Rebecca Hahn, Paul Sorajja, Fabien Praz, Philipp Lurz
Transcatheter tricuspid valve interventions (TTVI) are emerging as alternatives to surgery in high-risk patients with isolated or concomitant tricuspid regurgitation. The development of new minimally invasive solutions potentially more adapted to this largely undertreated population of patients, has fuelled the interest for the tricuspid valve. Growing evidence and new concepts have contributed to
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Kidney replacement therapy: trends in incidence, treatment, and outcomes of myocardial infarction and stroke in a nationwide Scottish study Eur. Heart J. (IF 39.3) Pub Date : 2024-03-01 Peter J Gallacher, David Yeung, Samira Bell, Anoop S V Shah, Nicholas L Mills, Neeraj Dhaun
Background and Aims Patients with kidney failure have a higher risk of cardiovascular disease compared with the general population. Whilst temporal trends of myocardial infarction and stroke are declining in the general population, these have not been evaluated in patients with kidney failure. This study aimed to describe national trends in the incidence, treatment, and outcomes of myocardial infarction
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Rheumatoid arthritis and cardiovascular complications during delivery: a United States inpatient analysis Eur. Heart J. (IF 39.3) Pub Date : 2024-03-01 Salman Zahid, Mohamed S Mohamed, Aardra Rajendran, Anum S Minhas, Muhammad Zia Khan, Noreen T Nazir, Anthony J Ocon, Brittany N Weber, Ijeoma Isiadinso, Erin D Michos
Background and Aims Persons with rheumatoid arthritis (RA) have an increased risk of obstetric-associated complications, as well as long-term cardiovascular (CV) risk. Hence, the aim was to evaluate the association of RA with acute CV complications during delivery admissions. Methods Data from the National Inpatient Sample (2004–2019) were queried utilizing ICD-9 or ICD-10 codes to identify delivery
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Arm and ankle blood pressure indices, and peripheral artery disease, and mortality: a cohort study Eur. Heart J. (IF 39.3) Pub Date : 2024-03-01 Kamel Mohammedi, Marie Pigeyre, Jackie Bosch, Salim Yusuf, Hertzel C Gerstein
Background and Aims Few studies have compared arm and ankle blood pressures (BPs) with regard to peripheral artery disease (PAD) and mortality. These relationships were assessed using data from three large prospective clinical trials. Methods Baseline BP indices included arm systolic BP (SBP), diastolic BP (DBP), pulse pressure (arm SBP minus DBP), ankle SBP, ankle–brachial index (ABI, ankle SBP divided
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MBNL1 Regulates Programmed Postnatal Switching Between Regenerative and Differentiated Cardiac States Circulation (IF 37.8) Pub Date : 2024-03-01 Logan R.J. Bailey, Darrian Bugg, Isabella M. Reichardt, C. Dessirée Ortaç, Abigail Nagle, Jagadambika Gunaje, Amy Martinson, Richard Johnson, Michael J. MacCoss, Tomoya Sakamoto, Daniel P. Kelly, Michael Regnier, Jennifer M. Davis
BACKGROUND:Discovering determinants of cardiomyocyte maturity is critical for deeply understanding the maintenance of differentiated states and potentially reawakening endogenous regenerative programs in adult mammalian hearts as a therapeutic strategy. Forced dedifferentiation paired with oncogene expression is sufficient to drive cardiac regeneration, but elucidation of endogenous developmental regulators
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Hypertension, Neurodegeneration, and Cognitive Decline Hypertension (IF 8.3) Pub Date : 2024-03-01 Anthony Pacholko, Costantino Iadecola
Elevated blood pressure is a well-established risk factor for age-related cognitive decline. Long linked to cognitive impairment on vascular bases, increasing evidence suggests a potential association of hypertension with the neurodegenerative pathology underlying Alzheimer disease. Hypertension is well known to disrupt the structural and functional integrity of the cerebral vasculature. However, the
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Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond Hypertension (IF 8.3) Pub Date : 2024-03-01 Nicholas D. Camarda, Jaime Ibarrola, Lauren A. Biwer, Iris Z. Jaffe
After half a century of evidence suggesting the existence of mineralocorticoid receptors (MR) in the vasculature, the advent of technology to specifically knockout the MR from smooth muscle cells (SMCs) in mice has elucidated contributions of SMC-MR to cardiovascular function and disease, independent of the kidney. This review summarizes the latest understanding of the molecular mechanisms by which
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Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes Circ. Res. (IF 20.1) Pub Date : 2024-02-29 Dan Zhao, Zeng-Kang Huang, Yu Liang, Zhi-Jun Li, Xue-Wei Zhang, Kun-Hang Li, Hao Wu, Xu-Dong Zhang, Chen-Sheng Li, Dong An, Xue Sun, Ming-Xin An, Jun-Xiu Shi, Yi-Jun Bao, Li Tian, Di-Fei Wang, An-Hua Wu, Yu-Hua Chen, Wei-Dong Zhao
Background:Microvascular complications are the major outcome of type 2 diabetes progression, and the underlying mechanism remains to be determined.Methods:High-throughput RNA sequencing was performed using human monocyte samples from controls and diabetes. The transgenic mice expressing human CTSD (cathepsin D) in the monocytes was constructed using CD68 promoter. In vivo 2-photon imaging, behavioral
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Cardiovascular Consequences of Uremic Metabolites: an Overview of the Involved Signaling Pathways Circ. Res. (IF 20.1) Pub Date : 2024-02-29 Adelina Curaj, Raymond Vanholder, Joseph Loscalzo, Kaiseng Quach, Zhuojun Wu, Vera Jankowski, Joachim Jankowski
The crosstalk of the heart with distant organs such as the lung, liver, gut, and kidney has been intensively approached lately. The kidney is involved in (1) the production of systemic relevant products, such as renin, as part of the most essential vasoregulatory system of the human body, and (2) in the clearance of metabolites with systemic and organ effects. Metabolic residue accumulation during
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Early Career Research Support From the American Heart Association: to the Second Century and Beyond Circ. Res. (IF 20.1) Pub Date : 2024-02-29 Jessica Pfleger, Ronald J. Vagnozzi
On June 10, 2024, the American Heart Association (AHA) enters its 100th year as an organization dedicated to the fight against heart disease and stroke, thus fostering a world of longer, healthier lives. This critical work includes essential lifesaving measures such as annual CPR training for ≈22 million people and enrolling more than 2600 hospitals in Get With The Guidelines, a program that provides
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In This Issue Circ. Res. (IF 20.1) Pub Date : 2024-02-29
Ponatinib is used for the treatment of particular cases of chronic myeloid leukemia (CML) that don’t respond to other medications. Unfortunately, the drug can have life-threatening cardiovascular side effects including cardiomyopathy and heart failure. Ponatinib is known to induce mitochondrial dysfunction, which is linked to the cellular stress response. But whether the drug itself activates the stress
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PIEZO Ion Channels in Cardiovascular Functions and Diseases Circ. Res. (IF 20.1) Pub Date : 2024-02-29 Bertrand Coste, Patrick Delmas
The cardiovascular system provides blood supply throughout the body and as such is perpetually applying mechanical forces to cells and tissues. Thus, this system is primed with mechanosensory structures that respond and adapt to changes in mechanical stimuli. Since their discovery in 2010, PIEZO ion channels have dominated the field of mechanobiology. These have been proposed as the long-sought-after
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Large animal models of pressure overload-induced cardiac left ventricular hypertrophy to study remodeling of the human heart with aortic stenosis Cardiovasc. Res. (IF 10.8) Pub Date : 2024-02-29 Evangelia Beslika, Adelino Leite-Moreira, Leon J De Windt, Paula da Costa Martins
Pathologic cardiac hypertrophy is a common consequence of many cardiovascular diseases, including aortic stenosis. Aortic stenosis is known to increase the pressure load of the left ventricle, causing a compensative response of the cardiac muscle, which progressively will lead to dilation and heart failure. In a cellular level, this corresponds to a considerable increase in the size of cardiomyocytes