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A new study has identified a scavenger receptor-independent mechanism of atherosclerosis development by showing that LDL uptake through macropinocytosis contributes to macrophage foam cell formation and atherosclerosis development and that an FDA-approved drug that inhibits macropinocytosis inhibits atherosclerosis development in mice.

A 54-year-old woman was admitted to the intensive care unit with septic shock induced by intraabdominal infection. An initial physical examination revealed a body temperature of 38.6°C, a blood pressure of 82/56 mm Hg, a pulse rate of 109 beats per minute, and a respiratory rate of 26 breaths/minute. At admission, a 12-lead ECG was performed (Figure 1). Serum troponin I level was 2.02 ng/mL (normal

A central dogma in cardiac biology is that the postnatal heart adopts a fetal-like transcriptional state in response to stress.1 Consequently, the so-called “fetal gene program” is frequently used as a surrogate marker of adverse cardiac remodeling and heart failure in preclinical models.2 Fetal gene reactivation in heart failure is traditionally studied in cardiomyocytes; however, the extent to which

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The addition of acetazolamide to loop diuretic therapy improves the success of decongestion in patients with acute decompensated heart failure and volume overload.

Background:Preeclampsia is associated with maternal and perinatal morbidity. Besides acute therapy for severe hypertension, best practices are lacking for intrapartum hypertension management. Our objective was to test the hypothesis that intrapartum initiation of extended-release nifedipine in individuals with preeclampsia with severe features prevents severe hypertension.Methods:Randomized, triple-blind

Aims Non-renal extravasation of phosphate from the circulation and transient accumulation into tissues and extracellular fluid is a regulated process of acute phosphate homeostasis that is not well understood. This process is especially relevant in the setting of chronic kidney disease (CKD), where exposure to increased phosphate is prolonged due to inefficient kidney excretion. Furthermore, CKD-associated

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Cold shock domain-containing protein E1 (CSDE1) has been identified as a novel post-transcriptional regulator of LDL receptor levels in the liver.

Background:In the STEP trial (Strategy of Blood Pressure Intervention in older Hypertensive Patients), the risk of cardiovascular events is significantly lower in patients who received intensive systolic blood psressure (BP) treatment than in those who received standard treatment. This study compared the lifetime health benefits and medical costs of intensive BP treatment with those of standard BP

Sarcoidosis is a rare inflammatory disease in which granulomas—small, localized sites of inflammation—afflict various parts of the body, most commonly the lungs, skin and lymph nodes. While sarcoidosis can be managed, there is no cure for the condition and, if it manifests in the heart, it can be deadly. Because little is known about the specific pathology of cardiac sarcoidosis (CS), and because it

Dr Jing Liu ia a resident doctor of Medicine (Cardiology). She earned her MD from Xi’an Jiaotong University and completed her medicine internship followed by a PhD program (Cardiovascular Medicine) at Xi’an Jiaotong University. She completed her PhD joint training program at Washington University in St. Louis. Supervised by Dr Kory Lavine, Dr Liu took a deep interest in cardiac immunology and set her

Spurred by the 2016 release of the National Heart, Lung, and Blood Institute’s Strategic Vision, the Division of Cardiovascular Sciences developed its Strategic Vision Implementation Plan—a blueprint for reigniting the decline in cardiovascular disease (CVD) mortality rates, improving health equity, and accelerating translation of scientific discoveries into better cardiovascular health (CVH). The

In the article by Li et al, “Mitochondrial H2S Regulates BCAA Catabolism in Heart Failure,” which was published in the July 2022 issue (Cir Res. 2022; 131:222-235. doi: 10.1161/CIRCRESAHA.121.319817), a correction was needed. In Figure 3B, which illustrates the LV ejection fraction throughout the 12-week study for 3-MST KO and wild-type control mice, the bar graph was misplaced. During figure processing

Aims Accumulation of mononuclear phagocytes (monocytes, macrophages and dendritic cells) in the vessel wall is a hallmark of atherosclerosis. Using integrated single-cell analysis of mouse and human atherosclerosis, we here aimed to refine the nomenclature of mononuclear phagocytes in atherosclerotic vessels, and to compare their transcriptomic profiles in mouse and human disease. Methods and results

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BACKGROUND:Hypertension is a common cardiovascular disease that is related to genetic and environmental factors, but its mechanisms remain unclear. DNA methylation, a classic epigenetic modification, not only regulates gene expression but is also susceptible to environmental factors, linking environmental factors to genetic modification. Therefore, globally screening differential genomic DNA methylation

Remarkable advances in the management of coronary artery disease have enhanced our approach to left main coronary artery (LMCA) disease. The traditional role of coronary artery bypass graft surgery has been challenged by the less invasive percutaneous coronary interventional approach. Additionally, major strides in optimal medical therapy now provide a rich menu of treatment choices in selected circumstances

AIMS At least 50% of deaths due to coronary artery disease (CAD) are sudden cardiac deaths (SCDs), but the role of acute plaque complications on the incidence of sudden death in CAD is somewhat unclear. The present study aimed to investigate plaque histology and concomitant myocardial disease in sudden coronary death. METHODS AND RESULTS The study population is derived from the Fingesture study, which