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Mitochondrial innate immune signaling in skeletal muscle adaptation to exercise Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-06-12 Jin Ma, Annie Yujin Son, Youlim Son, Ping-yuan Wang, Paul M. Hwang
Exercise-induced inflammation is regarded as a response to muscle damage from mechanical stress, but controlled immune signaling can be beneficial by promoting metabolic adaptation which, for example, decreases obesity and lowers the risk of diabetes. In addition to oxidative metabolism, mitochondria play a central role in initiating innate immune signaling. We review recent work that has identified
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The trade-off between reproduction and resilience Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-06-10 Liankui Zhou, Ying Liu
The mitochondrial unfolded protein response (UPRmt) is a transcriptional program that alleviates mitochondrial dysfunction by facilitating the recovery of the mitochondrial network. In Caenorhabditis elegans, reproductive maturity leads to suppression of the UPRmt, suggesting a trade-off between maintenance of stress resilience and fertility. Here, we examine emerging evidence suggesting that the
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Current approaches and advances in placental toxicology. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-06-04 Almudena Veiga-Lopez,Elana R Elkin,Sean M Harris,Bevin E Blake,Alison G Paquette,Lauren M Aleksunes,Phoebe A Stapleton
Despite the crucial role of the placenta in supporting pregnancy and fetal development, research into its susceptibility to environmental exposures has been limited by methodological challenges. We review diverse approaches to studying placental biology and responses to chemical exposures, and provide a comprehensive assessment of traditional and emerging methodologies. Beginning with an overview of
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Understanding metabolic resilience by unraveling temporal dynamics of cellular responses. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-26 Paniz Jasbi,Alex E Mohr,Meghana Hosahalli Shivananda Murthy,Judith Klein-Seetharaman
Metabolic resilience is essential for organismal homeostasis under diverse external pressures, because responding and adapting to stressors requires energy and drives changes at every omic level. The goal of this paper is to synthesize recent advances in understanding the intricate interplay, especially between metabolic and transcriptomic responses, involved in addressing external perturbations. We
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Expanding the understanding of insulin resistance in brain and periphery. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-19 Wenqiang Chen,Stephanie Kullmann,Elizabeth M Rhea
Insulin resistance is a central feature of metabolic disorders such as type 2 diabetes (T2D). While studies on this disorder have largely been linked to glucose metabolism and intracellular signaling, recent advances reveal that insulin resistance extends beyond traditional glucose regulatory pathways, impacting multiple organs including the brain, contributing to cognitive dysfunction and neurodegenerative
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B vitamins as adjunct therapies for depressive disorder. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-14 Zi-Qing Zheng,Liang Shen,Li-Ming Zhao,Hong-Fang Ji
The rising prevalence of depressive disorder worldwide requires better interventional avenues. B vitamins are gaining increasing interest as potential therapeutic approaches in this context given current evidence for a bidirectional association between B vitamin deficiency and depressive disorder. We discuss how B vitamins and B vitamin-associated probiotic supplementation may represent an effective
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Metabolomics-enabled biomarker discovery in breast cancer research. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-13 Julia Füreder,Eva S Schernhammer,A Heather Eliassen,Sabina Sieri,Benedikt Warth
Breast cancer (BC) remains the most prevalent malignancy among women worldwide. While genetic predisposition and reproductive history are key contributors to its development, modifiable risk factors are also important, particularly those linked to lifestyle behaviors, often influencing the endogenous metabolome. Over the past decade, mass spectrometry-based metabolomics has enabled agnostic investigations
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Molecular targets of bempedoic acid and related decoy fatty acids. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-08 Julianna G Supplee,Ronen Marmorstein,Kathryn E Wellen
Disorders of lipid metabolism, including hyperlipidemia, atherosclerosis, and metabolic dysfunction-associated steatotic liver disease, are increasing across the globe. Bempedoic acid (BPA) is a first-in-class drug for the treatment of hypercholesterolemia and cardiac risk reduction, which may particularly benefit those who do not tolerate statins. Inhibition of hepatic ATP-citrate lyase (ACLY) is
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Healthy choices, healthy futures: promoting healthy nutrition to curb non-communicable diseases Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-07 Saurabh Kumar Gupta, Tina Rawal, Monika Arora
Non-communicable diseases (NCDs) pose a serious challenge to global public health, compounded by unhealthy nutrition and obesogenic environments. This science and society article emphasizes several evidence-based behavior-change strategies, policy interventions, and meaningful youth engagement to promote healthy nutrition choices among children and adolescents.
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Balancing metabolism and regeneration in liver diseases through HNF4α targeting. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-05 Céline Van Dender,Jolien Vandewalle,Claude Libert
Transcription factor hepatocyte nuclear factor 4 alpha (HNF4α) is considered the master regulator of hepatocyte differentiation. During homeostasis, HNF4α maintains liver identity by supporting metabolism while inhibiting proliferation. It is downregulated in response to both acute and chronic insults; however, although this supports hepatic regeneration in mild acute settings, severe or chronic downregulation
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Dietary and pharmacological energy restriction and exercise for healthspan extension Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-02 Maria Lastra Cagigas, Isabella De Ciutiis, Andrius Masedunskas, Luigi Fontana
Extending healthspan – the years lived in optimal health – holds transformative potential to reduce chronic diseases and healthcare costs. Dietary restriction (DR), particularly when combined with nutrient-rich diets and exercise, is among the most effective, evidence-based strategies for enhancing metabolic health and longevity. By targeting fundamental pathways, it mitigates the onset and progression
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Seeding microbes in defined early-life windows to fight diabetes. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-05-01 Shuqin Zeng,Shaopu Wang,Dezhi Mu
Establishment of the early-life gut microbiome, coinciding with the host development, predisposes to long-term disease risk if disrupted. Recently, Hill et al. precisely delineated a critical early-life window in humans and mice during which specific fungi and bacteria play indispensable roles in β-cell development, thereby regulating lifelong metabolic homeostasis.
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NAD augmentation as a disease-modifying strategy for neurodegeneration. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-25 Christian Dölle,Charalampos Tzoulis
Neurodegenerative diseases (NDDs) pose a significant and rapidly growing global health challenge, but there are no effective therapies to delay or halt progression. In recent years augmentation of nicotinamide adenine dinucleotide (NAD) has emerged as a promising disease-modifying strategy that targets multiple key disease pathways across multiple NDDs, such as mitochondrial dysfunction, energy deficits
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Genetics and epigenetics in gestational diabetes contributing to type 2 diabetes. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-24 Dewei Kong,Oliwia Kowalik,Emma Garratt,Keith M Godfrey,Shiao-Yng Chan,Adrian Kee Keong Teo
Gestational diabetes mellitus (GDM) is a common pregnancy complication and a risk factor for the subsequent development of type 2 diabetes (T2D) in mothers and of several metabolic diseases in offspring. However, the molecular underpinnings of these risks are not well understood. Genome-wide association studies (GWAS) and epigenetic studies may provide complementary insights into the causal relationships
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The interplay between endometriosis and obesity. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-24 Md Saidur Rahman,Yunjeong Park,Hossein Hosseinirad,Jung-Ho Shin,Jae-Wook Jeong
Endometriosis, characterized by uterine-like tissue growth outside the uterus, is a complex disorder with significant clinical implications. This review explores how body composition - both low body mass index (BMI) and obesity - modulates endometriosis progression through metabolic, hormonal, and immune-inflammatory pathways. Obesity-driven leptin signaling emerges as a pivotal link, promoting systemic
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Promising results but caution needed in GLP-1RA large scale epidemiology Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-24 Salil V. Deo, Naveed A. Sattar
Investigating the association between glucagon-like peptide 1 receptor agonists (GLP1-RAs) and incident disease across 175 health outcomes in US Veterans with diabetes, Xie et al. recently reported lower risk for cardiokidney disease and substance use disorders, but higher risk for pancreatitis, gastrointestinal disorders, and arthritis. However, many apparent novel findings need testing or validation
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(Poly)phenols as bioactive constituents linked to dietary fibre metabolic fate Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-16 Jara Pérez-Jiménez, Yolanda Sanz, Rosa M. Lamuela-Raventós
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Fumarate integrates metabolism and immunity in diseases. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-16 Jie Cheng,Yifeng Xiao,Peng Jiang
Fumarate is a key metabolite produced primarily by the tricarboxylic acid (TCA) and urea cycles. In addition to having a metabolic role, its electrophilicity enables it to covalently modify cysteines; moreover, because of its α-ketoglutarate (α-KG)-like structure, it can also act as a competitive inhibitor of α-KG-dependent dioxygenases for epigenetic remodeling. Recent advances have broadened the
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Adipose tissue-targeting nanomedicines for obesity pharmacotherapy. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-14 Lingling Wang,Qingyi Jia,Jinhan He,Yanping Li
The increasing global prevalence of obesity presents a substantial challenge to public health. Current nutrient-stimulated hormone (NuSH)-based therapeutics are hindered by receptor desensitization, muscle loss, and weight regain. The adipose tissue, the primary organ responsible for energy storage and metabolic management, is a promising target for obesity treatment. Nanomedicine holds promise to
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Targeting PKLR in liver diseases Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-11 Meng Yuan, Mengnan Shi, Hong Yang, Sajda Ashraf, Shazia Iqbal, Hasan Turkez, Jan Boren, Cheng Zhang, Mathias Uhlén, Ozlem Altay, Adil Mardinoglu
Pyruvate kinase is a key regulator in hepatic glucose metabolism, encoded by the gene pyruvate kinase liver/red blood cells (PKLR). Systems biology-based approaches, including metabolic and gene co-expression networks analyses, as well as genome-wide association studies (GWAS), have led to the identification of PKLR as a pivotal gene influencing liver metabolism in patients with metabolic dysfunction-associated
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Crotonyl-coenzyme A (crotonyl-CoA) Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-10 Yu Wang, Hou-Zao Chen, Xiaoqiang Tang
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Advancing precision medicine in metabolic dysfunction-associated steatotic liver disease. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-10 Bryan A Priego-Parra,Rocío Gallego-Durán,Berenice M Román-Calleja,José Antonio Velarde-Ruiz Velasco,Manuel Romero-Gómez,Jordi Gracia-Sancho
Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), has become a pressing global health concern. The complexity of MASLD and the lack of universally effective treatments expose the limitations of current interventions, which focus mainly on lifestyle modifications. Here, we explore the multilayered nature of MASLD, emphasizing
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Integrating cancer medicine into metabolic rhythms. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-07 Keyu Su,Deshun Zeng,Weiru Zhang,Fei Peng,Bai Cui,Quentin Liu
Circadian rhythms are cell-intrinsic time-keeping mechanisms that allow organisms to adapt to 24-h environmental changes, ensuring coordinated physiological functions by aligning internal metabolic oscillations with external timing cues. Disruption of daily metabolic rhythms is associated with pathological events such as cancer development, yet the mechanisms by which perturbed metabolic rhythms contribute
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Can kisspeptin be a new treatment for sexual dysfunction? Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-05 Julie Bakker
The neuropeptide kisspeptin activates the hypothalamic-pituitary-gonadal (HPG) axis and influences neural circuits controlling sexual behavior. Animal studies have determined its sex-specific roles in reproductive behaviors, whereas human research has linked kisspeptin to increased brain activity in regions associated with sexual and emotional processing, making it a potential treatment for disorders
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Shaping the future of youth-onset type 2 diabetes: a call to action. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-04-04 Amy S Shah,Megan M Kelsey,Risa M Wolf,Kristen J Nadeau
Youth-onset type 2 diabetes (YO-T2D) is an urgent public health challenge that demands immediate and innovative action. The devastating trajectory of this disease - from rapid β-cell decline to early complications and poor responses to medications - compels us to rethink our approach. Here, we argue that by investing in targeted research to unravel the unique mechanisms of this condition, ensuring
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Hidden players in the metabolic vulnerabilities of amyotrophic lateral sclerosis. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-03-15 Marco Rosina,Silvia Scaricamazza,Gianmarco Fenili,Valentina Nesci,Cristiana Valle,Alberto Ferri,Maria Paola Paronetto
Amyotrophic lateral sclerosis (ALS) is a complex and rapidly progressive motor neuron disorder with a fatal outcome. Despite the remarkable progress in understanding ALS pathophysiology, which has significantly contributed to clinical trial design, ALS remains a rapidly disabling and life-shortening condition. The non-motor neuron features of ALS, including nutritional status, energy expenditure, and
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Managing diabetes across female reproductive stages Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-03-14 Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal
Hormonal fluctuations across the female reproductive lifespan lead to physiological adjustments that impact insulin sensitivity and glucose metabolism, generating unique challenges in diabetes management. Although current guidelines focus primarily on diabetes care during pregnancy, they lack tailored recommendations for addressing glycaemic variability associated with menstrual cycles, contraceptive
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Recognizing the role of fibromyalgia in post-exertional malaise. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-03-11 Alessandro Giollo,Mariangela Salvato,Andrea Doria
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Enhancer binding as a KEysTONE of fasting response Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-03-08 Nathaniel F. Henneman, Ganna Panasyuk
Fasting is a recurrent daily energy stress that benefits healthspan and lifespan. While ketones fuel fasting in vertebrates, the underlying transcriptional mechanism remains incompletely understood. Recently, Korenfeld et al. revealed peroxisome proliferator-activated receptor alpha (PPARα)-dependent enhancer priming as a keystone for ketone production, increasing our understanding of mechanisms underlying
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Myeloid-derived suppressor cells in metabolic and cardiovascular disorders. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-03-01 Jingwei Yan,Shuai Guo,Jun He,Hanpeng Huang,Yiming Xu
Dysregulation of immune homeostasis can precipitate chronic inflammation, thus significantly contributing to the onset and progression of metabolic and cardiovascular diseases. Myeloid-derived suppressor cells (MDSCs) constitute a heterogeneous population of immature myeloid cells that are mobilized in response to biological stressors such as tissue damage and inflammation. Although MDSCs have been
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Hallmarks of ovarian aging Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-02-24 Chuqing Wu, Dan Chen, Michael B. Stout, Meng Wu, Shixuan Wang
Ovarian aging is considered to be the pacemaker of female aging, and is linked to various comorbidities such as osteoporosis, cardiovascular diseases, and cognitive decline. Many efforts have been made to determine the mechanisms underlying ovarian aging, but their potential to act as hallmarks to predict and intervene in this process currently remains unclear. In this review we propose nine hallmarks
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Insights from omics research on plant-based diets and cardiometabolic health Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-02-20 Hyunju Kim, Casey M. Rebholz
Plant-based diets emphasize higher intake of plant foods and are low in animal products. Individuals following plant-based diets have a lower risk of chronic conditions; however, the mechanisms underlying these associations are not completely understood. Omics data have opened opportunities to investigate the mechanistic effect of dietary intake on health outcomes. Here, we review omics analyses of
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Prediabetes remission to reduce the global burden of type 2 diabetes. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-02-14 Leontine Sandforth,Stephanie Kullmann,Arvid Sandforth,Andreas Fritsche,Reiner Jumpertz-von Schwartzenberg,Norbert Stefan,Andreas L Birkenfeld
Prediabetes is a highly prevalent and increasingly common condition affecting a significant proportion of the global population. The heterogeneous nature of prediabetes presents a challenge in identifying individuals who particularly benefit from lifestyle or other therapeutic interventions aiming at preventing type 2 diabetes (T2D) and associated comorbidities. The phenotypic characteristics of individuals
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Do weight loss interventions challenge the obesity paradox in heart failure? Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-02-11 Salva R. Yurista, Robert A. Eder, W. Scott Butsch, Ivan Luptak
Cardiovascular disease (CVD) remains a significant global health concern, with obesity recognized as a prominent risk factor. The ‘obesity paradox’ (OP) suggests that obesity does not always lead to adverse outcomes, particularly in heart failure (HF). In this forum, we discuss the relevance of the OP in the current therapeutic landscape for cardiometabolic diseases.
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Glucagon-like peptide-1 receptor agonism and end-organ protection Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-02-10 Samuel Daniels, Cecilia Karlsson, Patrick Schrauwen, Victoria E.R. Parker
Identification of exendin-4 (a glucagon-like peptide-1 receptor agonist, GLP-1RA) in Gila monster venom may be regarded as one of the most serendipitous discoveries of recent times. GLP-1RAs are now an established therapeutic approach in type 2 diabetes (T2D), body weight management, and cardiovascular (CV) risk protection. Furthermore, there is a growing platform of evidence that GLP-1RA has extended
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Subcellular mitochondrial heterogeneity enables opposing metabolic demands Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-01-28 Brandon Chen, Yatrik M. Shah, Costas A. Lyssiotis
Mitochondria perform essential metabolic processes that sustain cellular bioenergetics and biosynthesis. In a recent article, Ryu et al. explored how mitochondria coordinate biochemical reactions with opposing redox demands within the same cell. They demonstrate that subcellular mitochondrial heterogeneity enables metabolic compartmentalization to permit concurrent oxidative ATP production and reductive
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Lineage tracing of pancreatic cells for mechanistic and therapeutic insights. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-01-18 Huan Zhao,Bin Zhou
Recent advances in lineage-tracing technologies have significantly improved our understanding of pancreatic cell biology, particularly in elucidating the ontogeny and regenerative capacity of pancreatic cells. A deeper appreciation of the mechanisms underlying pancreatic cell identity and plasticity holds the potential to inform the development of new therapeutic modalities for conditions such as diabetes
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Widening research horizons on metabolic dysfunction-associated steatotic liver disease and cancer. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-01-09 Amedeo Lonardo,Norbert Stefan,Alessandro Mantovani
Liver fibrosis and biological sex variably modulate the risks of hepatocellular carcinoma (HCC) and extrahepatic cancers (EHCs) arising in the context of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we highlight how these variables may have implications in the setting of chemoprevention and precision medicine approaches in MASLD and guide additional research.
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Gut feelings on short-chain fatty acids to regulate respiratory health. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-01-04 Samantha N Rowland,Christopher G Green,John R Halliwill,Aran Singanayagam,Liam M Heaney
Respiratory infections and diseases pose significant challenges to society and healthcare systems, underscoring the need for preventative and therapeutic strategies. Recent research in rodent models indicates that short-chain fatty acids (SCFAs), metabolites produced by gut bacteria, may offer medicinal benefits for respiratory conditions. In this opinion, we summarize the current literature that highlights
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Systemic metabolic crosstalk as driver of cancer cachexia. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-01-04 Elisabeth Wyart,Giovanna Carrà,Elia Angelino,Fabio Penna,Paolo E Porporato
Cachexia is a complex metabolic disorder characterized by negative energy balance due to increased consumption and lowered intake, leading to progressive tissue wasting and inefficient energy distribution. Once considered as passive bystander, metabolism is now acknowledged as a regulator of biological functions and disease progression. This shift in perspective mirrors the evolving understanding of
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The growing range of complications of diabetes mellitus. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-01-03 Peter S Hamblin,Anthony W Russell,Stella Talic,Sophia Zoungas
With the rising prevalence of type 2 diabetes mellitus (T2DM) and obesity, several previously under-recognised complications associated with T2DM are becoming more evident. The most common of these emerging complications are metabolic dysfunction-associated steatotic liver disease (MASLD), cancer, dementia, sarcopenia, and frailty, as well as other conditions involving the lung, heart, and intestinal
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Tumor-intrinsic regulators of the immune-cold microenvironment of prostate cancer. Trends Endocrin. Met. (IF 11.4) Pub Date : 2025-01-02 Lourdes Brea,Jindan Yu
Prostate cancer (PC) is a notoriously immune-cold tumor in that it often lacks substantial infiltration by antitumor immune cells, and in advanced diseases such as neuroendocrine PC, it could be devoid of immune cells. A majority of PC patients thus have, unfortunately, been unable to benefit from recent advances in immunotherapies. What causes this immunosuppressive microenvironment around PC? In
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Sex- and endurance training-mediated cardiovascular protection through lipids during exercise. Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-31 Julia An,Ariel S Thorson,David H Wasserman,John M Stafford,Lin Zhu
Premenopausal women and endurance-trained individuals of either sex have reduced cardiovascular disease (CVD) risk. Endurance training shifts fuel selection towards fats to spare carbohydrates; interestingly, women prioritize fats as an energy resource more than men do during exercise. Relying on fats during exercise drives whole-body lipolysis and promotes lipid uptake and oxidation capacity in skeletal
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Lipids guide T cell antitumor immunity by shaping their metabolic and functional fitness. Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-31 Letizia Rumiano,Teresa Manzo
Lipids are metabolic messengers essential for energy production, membrane structure, and signal transduction. Beyond their recognized role, lipids have emerged as metabolic rheostats of T cell responses, with distinct species differentially modulating CD8+ T cell (CTL) fate and function. Indeed, lipids can influence T cell signaling by altering their membrane composition; in addition, they can affect
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Epigenetic inheritance of PCOS by developmental programming and germline transmission Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-27 Elisabet Stener-Victorin, Qiaolin Deng
Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder, affecting approximately 11–13% of women of reproductive age. Women with PCOS experience a higher prevalence of infertility, pregnancy complications, and cardiometabolic disorders such as obesity, insulin resistance, and type 2 diabetes mellitus. Furthermore, psychiatric comorbidities, including depression and anxiety
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Can ferroptosis be a target for reproductive health? Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-19 Mengchun Hu, Yingying Qin, Xue Jiao
Ferroptosis has been implicated in several reproductive disorders, but the underlying mechanisms remain unknown; thus, interventions targeting this pathway are lacking. Here we summarize the emerging findings on ferroptosis in reproductive biology and corresponding disorders, and highlight perspectives and challenges on future ferroptosis research with potential clinical applications.
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Circadian disruption and its impact on the cardiovascular system. Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-19 Morag J Young,Seamus Heanue,Monica Kanki,Kegan J Moneghetti
Circadian rhythms are highly conserved biorhythms of ~24 h that govern many fundamental biological processes, including cardiovascular (CV) homeostasis. Disrupting the timing of cellular oscillators promotes cellular stress, and induction of pathogenic pathways underpins the pathogenesis of many CV diseases (CVDs). Thus, shift work, late eating, sleep disturbances, and other disruptors can result in
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Shared metabolic and stress pathways to neonatal adiposity Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-18 Sonja Entringer, Gernot Desoye
Perceived stress levels, prevalence of pregnancies complicated by metabolic disorders, and childhood obesity have been increasing steadily. We here propose a pathway integrating stress-responsive biological systems into the established effects of maternal diabetes and obesity during pregnancy, overall exerting a combined contribution to offspring adiposity risk.
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More than carriers, orosomucoids are key metabolic modulators Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-18 Mi Jeong Heo, Inyoung Cheon, Kang Ho Kim
Orosomucoids (ORMs) have historically been considered as carriers involved in drug and lipid delivery. However, recent studies indicate ORM2 as a hepatokine involved in metabolic regulation. Here, we highlight the functions of ORM2 in controlling metabolic health and disease, focusing on its newly discovered regulatory mechanisms.
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Exploring tryptophan metabolism in cardiometabolic diseases Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-17 Nirmala Mouttoulingam, Soraya Taleb
Tryptophan (Trp) metabolism is linked to health and disease, with indoleamine 2,3-dioxygenase 1 (IDO) being a key enzyme in its breakdown outside the liver. This process produces metabolites that influence metabolic and inflammatory responses. A distinctive feature of the gut is its involvement in three major Trp catabolic pathways: the IDO-driven kynurenine pathway, bacteria-produced indoles, and
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Skeletal muscle adaptations and post-exertional malaise in long COVID Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-17 Braeden T. Charlton, Richie P. Goulding, Richard T. Jaspers, Brent Appelman, Michèle van Vugt, Rob C.I. Wüst
When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional malaise (PEM), which is the worsening of symptoms following mental or physical exertion. There is little consensus on the pathophysiology of exercise-induced PEM
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Inter-organ communication is a critical machinery to regulate metabolism and aging. Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-17 Kyohei Tokizane,Shin-Ichiro Imai
Inter-organ communication (IOC) is a complex mechanism involved in maintaining metabolic homeostasis and healthy aging. Dysregulation of distinct forms of IOC is linked to metabolic derangements and age-related pathologies, implicating these processes as a potential target for therapeutic intervention to promote healthy aging. In this review, we delve into IOC mediated by hormonal signaling, circulating
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Intracellular endothelial cell metabolism in vascular function and dysfunction. Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-12 Kathryn M Citrin,Balkrishna Chaube,Carlos Fernández-Hernando,Yajaira Suárez
Endothelial cells (ECs) form the inner lining of blood vessels that is crucial for vascular function and homeostasis. They regulate vascular tone, oxidative stress, and permeability. Dysfunction leads to increased permeability, leukocyte adhesion, and thrombosis. ECs undergo metabolic changes in conditions such as wound healing, cancer, atherosclerosis, and diabetes, and can influence disease progression
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Can brain neurons change identity? Lessons from obesity. Trends Endocrin. Met. (IF 11.4) Pub Date : 2024-12-05 Jean Charles Nicolas,Thomas H Lee,Carmelo Quarta
It has long been thought that the functional identity of mammalian brain neurons is programmed during development and remains stable throughout adult life; however, certain populations of neurons continue to express active regulators of neuronal identity into adulthood. Prolonged exposure to diet-induced metabolic stress induces features of neuronal identity modification in adult mice, and maladaptive