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Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-03-08 Ifene David Festus, Jeri Spilberg, Martin E. Young, Sean Cain, Sepideh Khoshnevis, Michael H. Smolensky, Fariya Zaheer, Giannina Descalzi, Tami A. Martino
Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body’s daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound
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Metabolic remodeling in cancer and senescence and its therapeutic implications Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-03-06 Yeonju Kim, Yeji Jang, Mi-Sung Kim, Chanhee Kang
Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells – a critical component of the aging process
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Itaconate in host inflammation and defense Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-03-05 Dan Ye, Pu Wang, Lei-Lei Chen, Kun-Liang Guan, Yue Xiong
Immune cells undergo rapid and extensive metabolic changes during inflammation. In addition to contributing to energetic and biosynthetic demands, metabolites can also function as signaling molecules. Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory conditions. This metabolite binds to and regulates the function of diverse proteins intracellularly
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Evolving liver disease insights from NAFLD to MASLD Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-29 Xiude Fan, Yongfeng Song, Jiajun Zhao
The recent renaming of ‘non-alcoholic fatty liver disease’ (NAFLD) to ‘metabolic dysfunction-associated steatotic liver disease’ (MASLD) emphasizes metabolic dysfunction in steatotic liver disease and advocates for tailored, comprehensive treatment strategies, driving forward the development of personalized care and innovative therapeutic approaches.
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Nucleosides are overlooked fuels in central carbon metabolism Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-29 Abigail Strefeler, Joan Blanco-Fernandez, Alexis A. Jourdain
From our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and circulate throughout the body and tissues. Nucleosides and nucleotides are classically viewed as precursors of nucleic acids, but recently they have emerged as a novel energy source for central carbon metabolism. Through catabolism by nucleoside phosphorylases, the ribose sugar group is released and can provide
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Parathyroid hormone–PTH1R signaling in cardiovascular disease and homeostasis Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-29 Dwight A. Towler
Primary hyperparathyroidism (pHPT) afflicts our aging population with an incidence approaching 50 per 100 000 patient-years at a female:male ratio of ~3:1. Decisions surrounding surgical management are currently driven by age, hypercalcemia severity, presence of osteoporosis, renal insufficiency, or hypercalciuria with or without nephrolithiasis. Cardiovascular (CV) disease (CVD) is not systematically
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Vitamin K-dependent carboxylation in β-cells and diabetes Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-29 Julie Lacombe, Mathieu Ferron
Vitamin K is an essential micronutrient and a cofactor for the enzyme γ-glutamyl carboxylase, which adds a carboxyl group to specific glutamic acid residues in proteins transiting through the secretory pathway. Higher vitamin K intake has been linked to a reduced incidence of type 2 diabetes (T2D) in humans. Preclinical work suggests that this effect depends on the γ-carboxylation of specific proteins
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Systemic and organ-specific anti-inflammatory effects of sodium-glucose cotransporter-2 inhibitors Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-29 Mona Mashayekhi, Bilgunay Ilkin Safa, Matthew S.C. Gonzalez, Sangwon F. Kim, Justin B. Echouffo-Tcheugui
Inflammation plays an essential role and is a common feature in the pathogenesis of many chronic diseases. The exact mechanisms through which sodium-glucose cotransporter-2 (SGLT2) inhibitors achieve their much-acclaimed clinical benefits largely remain unknown. In this review, we detail the systemic and tissue- or organ-specific anti-inflammatory effects of SGLT2 inhibitors using evidence from animal
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Current status and future trends of the global burden of MASLD Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-29 Lei Miao, Giovanni Targher, Christopher D. Byrne, Ying-Ying Cao, Ming-Hua Zheng
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most common chronic liver disease globally, affecting more than a third of the world's adult population. This comprehensive narrative review summarizes the global incidence and prevalence rates of MASLD and its related adverse hepatic and extrahepatic outcomes. We also discuss the substantial economic burden of MASLD
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Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-28 Cindy X.W. Zhang, Alejandro A. Candia, Amanda N. Sferruzzi-Perri
The obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary between mother and fetus, is known to play a critical role in modulating the intrauterine environment and fetal development, and we now know that maternal obesity leads to increased inflammation
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Current status and future perspectives of FGF21 analogues in clinical trials Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-28 Zara Siu Wa Chui, Qing Shen, Aimin Xu
Recent advances in fibroblast growth factor 21 (FGF21) biology and pharmacology have led to the development of several long-acting FGF21 analogues and antibody-based mimetics now in various phases of clinical trials for the treatment of obesity-related metabolic comorbidities. The efficacy of these FGF21 analogues/mimetics on glycaemic control and weight loss is rather mild and inconsistent; nevertheless
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Mitochondrial dysfunction in lipid processing and gastrointestinal disorders Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-27 Yan Hu, Hao Huang, Rong Xiang
Mitochondrial dysfunctions predominantly cause encephalomyopathies with muscle atrophy and neurodegeneration. However, their impact on other tissues, particularly the gastrointestinal tract, requires further investigation. In a recent report in , used mice deficient in the mitochondrial aminoacyl-tRNA synthetase DARS2 to investigate the role of enterocytic mitochondria in dietary lipid processing and
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Lysine lactylation in the regulation of tumor biology Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-22 Zijian Yang, Yingqi Zheng, Qiang Gao
Lysine lactylation (Kla), a newly discovered post-translational modification (PTM) of lysine residues, is progressively revealing its crucial role in tumor biology. A growing body of evidence supports its capacity of transcriptional regulation through histone modification and modulation of non-histone protein function. It intricately participates in a myriad of events in the tumor microenvironment
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Dietary methionine restriction in cancer development and antitumor immunity Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-20 Ming Ji, Qing Xu, Xiaoling Li
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Metabolic dysregulation of lymphocytes in autoimmune diseases Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-13 Shuyi Wang, Niansheng Yang, Hui Zhang
Lymphocytes are crucial for protective immunity against infection and cancers; however, immune dysregulation can lead to autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Metabolic adaptation controls lymphocyte fate; thus, metabolic reprogramming can contribute to the pathogenesis of autoimmune diseases. Here, we summarize recent advances on how metabolic
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The landscape of fetus metabolism in maternal hyperglycemia Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-09 Miranda E. Kelly, Thomas F. Martinez, Cholsoon Jang
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Clinical potential of fasting in type 1 diabetes Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-07 Krista A. Varady, Mary-Claire Runchey, Sirimon Reutrakul, Alaina P. Vidmar, Lisa S. Chow
Most adults with type 1 diabetes (T1DM) are either overweight or obese. As such, dietary management is recommended as an adjunct to insulin treatment to improve glycemic control and facilitate weight loss in these patients. Time-restricted eating (TRE) is a form of intermittent fasting that offers a simplified approach to treating obesity in T1DM. TRE typically involves restricting eating to 6 to 10
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Establishing evidence for immune surveillance of β-cell senescence Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-02 Nayara Rampazzo Morelli, Jasmine Pipella, Peter J. Thompson
Cellular senescence is a programmed state of cell cycle arrest that involves a complex immunogenic secretome, eliciting immune surveillance and senescent cell clearance. Recent work has shown that a subpopulation of pancreatic β-cells becomes senescent in the context of diabetes; however, it is not known whether these cells are normally subject to immune surveillance. In this opinion article, we advance
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Exercise is also medicine for iron homeostasis Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-02 Abel Plaza-Florido, Alejandro Lucia, Carmen Fiuza-Luces
High-intensity interval training (HIIT) is gaining popularity as an effective exercise modality to improve cardiometabolic health. Combining high-throughput/sensitivity proteome analyses in subcutaneous adipose tissue with biochemical blood measures, recently provided mechanistic insights into a potential beneficial role of this exercise modality on iron homeostasis at the whole-body level.
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Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-01 Helena Leal, Catarina Carvalhas-Almeida, Ana Rita Álvaro, Cláudia Cavadas
The hypothalamus, a small and intricate brain structure, orchestrates numerous neuroendocrine functions through specialized neurons and nuclei. Disruption of this complex circuitry can result in various diseases, including metabolic, circadian, and sleep disorders. Advances in models and their integration with new technologies have significantly benefited research on hypothalamic function and pathophysiology
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Pathophysiology of human mitochondrial tRNA metabolism Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-02-01 Jian-Hui Zhang, Gilbert Eriani, Xiao-Long Zhou
Mitochondria play multiple critical roles in cellular activity. In particular, mitochondrial translation is pivotal in the regulation of mitochondrial and cellular homeostasis. In this forum article, we discuss human mitochondrial tRNA metabolism and highlight its tight connection with various mitochondrial diseases caused by mutations in aminoacyl-tRNA synthetases, tRNAs, and tRNA-modifying enzymes
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Ketogenesis favors oxidative phosphorylation to promote disease tolerance Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-31 Kátia Jesus, Luís F. Moita
is an opportunistic pathogen of great medical relevance, although the mechanisms involved in chronic infection are unclear. have now shown that systemic and local pathogen-induced ketone bodies (KBs) select strains that preserve respiratory integrity by failing to substantially increase glycolysis, which drives immunopathology resulting from resistance mechanisms.
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Genetics unravels protein–metabolite relationships Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-31 James R. Hilser, Aldons J. Lusis, Hooman Allayee
Integrating molecular traits into genetic studies enhances our understanding of how DNA variation influences complex clinical and physiological phenotypes. In a recent article, apply this systems genetics approach with proteomics and metabolomics data in plasma from humans to identify and validate several previously unrecognized causal protein–metabolite associations.
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The redox requirement and regulation during cell proliferation Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-22 Zhuoran Zhen, Jiankun Ren, Jiajun Zhu
The intracellular metabolic network comprises a variety of reduction–oxidation (redox) reactions that occur in a temporally and spatially distinct manner. In order to coordinate these redox processes, mammalian cells utilize a collection of electron-carrying molecules common to many redox reactions, including NAD, NADP, coenzyme Q (CoQ), and glutathione (GSH). This review considers the metabolic basis
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Energy homeostasis in the bone Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-18 Min Zhou, Yu-Ze An, Qi Guo, Hai-Yan Zhou, Xiang-Hang Luo
The bone serves as an energy reservoir and actively engages in whole-body energy metabolism. Numerous studies have determined fuel requirements and bioenergetic properties of bone under physiological conditions as well as the dysregulation of energy metabolism associated with bone metabolic diseases. Here, we review the main sources of energy in bone cells and their regulation, as well as the endocrine
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Targeting systemic and gut microbial metabolism in ER+ breast cancer Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-13 Hannah Heath, Ayca Nazli Mogol, Ashlie Santaliz Casiano, Qianying Zuo, Zeynep Madak-Erdogan
Estrogen receptor-positive (ER+) breast tumors have a better overall prognosis than ER− tumors; however, there is a sustained risk of recurrence. Mounting evidence indicates that genetic and epigenetic changes associated with resistance impact critical signaling pathways governing cell metabolism. This review delves into recent literature concerning the metabolic pathways regulated in ER+ breast tumors
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The impact of epitranscriptomic modifications on liver disease Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-11 Keith A. Berggren, Robert E. Schwartz, Ralph E. Kleiner, Alexander Ploss
RNA modifications have emerged as important mechanisms of gene regulation. Developmental, metabolic, and cell cycle regulatory processes are all affected by epitranscriptomic modifications, which control gene expression in a dynamic manner. The hepatic tissue is highly metabolically active and has an impressive ability to regenerate after injury. Cell proliferation, differentiation, and metabolism
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Recreating metabolic interactions of the tumour microenvironment Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-10 Rodrigo Curvello, Nikolaus Berndt, Sandra Hauser, Daniela Loessner
Tumours are heterogeneous tissues containing diverse populations of cells and an abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to adapt their metabolism to survive and grow. Besides epigenetic factors, the metabolism of cancer cells is shaped by crosstalk with stromal cells and extracellular components. To date, most experimental models neglect the complexity
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Advisory Board and Contents Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-08
Abstract not available
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Subscription and Copyright Information Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-08
Abstract not available
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Exploring the relationship between hyperlactatemia and anemia Trends Endocrin. Met. (IF 10.9) Pub Date : 2024-01-06 Shuping Zhang, Wei Liu, Tomas Ganz, Sijin Liu
Hyperlactatemia and anemia commonly coexist and their crosstalk is a longstanding mystery with elusive mechanisms involved in physical activities, infections, cancers, and genetic disorders. For instance, hyperlactatemia leads to iron restriction by upregulating hepatic hepcidin expression. Increasing evidence also points to lactate as a crucial signaling molecule rather than merely a metabolic byproduct
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RNAkines are secreted messengers shaping health and disease Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-12-29 Jing Li, Jingwen Fang, Xiaohong Jiang, Yujing Zhang, Antonio Vidal-Puig, Chen-Yu Zhang
Extracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways
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A clinical perspective on ectopic Cushing’s syndrome Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-12-23 Oskar Ragnarsson, C. Christofer Juhlin, David J. Torpy, Henrik Falhammar
Cushing’s syndrome (CS) refers to the clinical features of prolonged pathological glucocorticoid excess. About 10–20% of individuals with CS have ectopic CS (ECS), that is, an adrenocorticotropin (ACTH)-producing tumour outside the pituitary gland. ACTH-secreting neuroendocrine neoplasia (NENs) can arise from many organs, although bronchial NEN, small cell lung cancer (SCLC), pancreatic NEN, thymic
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Large metabolic swings: when feeding exceeds its goals Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-12-21 F, r, a, n, c, i, s, c, o, , J, ., G, ., , M, u, r, i, a, n, a
Exaggerated blood excursions of nutrients and endogenous molecules in response to food intake may have health consequences if they repeatedly exceed the capacity of homeostatic mechanisms. Here, I discuss the significance of abnormally high postprandial metabolic fluctuations, the role of some influencing factors, and suggest ways to avoid them.
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Mitochondrial quality control pathways sense mitochondrial protein import Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-12-15 Laurie P. Lee-Glover, Timothy E. Shutt
Mitochondrial quality control (MQC) mechanisms are required to maintain a functional proteome, which enables mitochondria to perform a myriad of important cellular functions from oxidative phosphorylation to numerous other metabolic pathways. Mitochondrial protein homeostasis begins with the import of over 1000 nuclear-encoded mitochondrial proteins and the synthesis of 13 mitochondrial DNA-encoded
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Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-12-13 Emily M. Esquea, Riley G. Young, Mauricio J. Reginato
High dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.
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Irisin limits amyloid-β buildup in Alzheimer’s disease Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-12-14 Mychael V. Lourenco
Mounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in Neuron, Kim et al. reported that the exercise-induced hormone irisin curbs amyloid-β buildup by promoting secretion of astrocyte-derived neprilysin. These findings may help explain the neuroprotection by irisin and exercise in Alzheimer’s disease.
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Metabolic challengers selecting tumor-persistent cells Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-12-09 Caterina Mancini, Giulia Lori, Erica Pranzini, Maria Letizia Taddei
Resistance to anticancer therapy still represents one of the main obstacles to cancer treatment. Numerous components of the tumor microenvironment (TME) contribute significantly to the acquisition of drug resistance. Microenvironmental pressures arising during cancer evolution foster tumor heterogeneity and facilitate the emergence of drug-resistant clones. In particular, metabolic pressures arising
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The ups and downs of bone-marrow adipose tissue in space Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-30 Guy Trudel, Gerd Melkus, Tammy Liu
Knowledge is rapidly accumulating on basic roles and modulation of bone-marrow adipose tissue (BMAT). Among key modulators are physical forces on bones as exerted by gravity and exercise. Studying humans returning from space has revealed that, in addition to physical forces, local energetics within the bone marrow can play modulatory roles.
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The evolutionary tug-of-war of macrophage metabolism during bacterial infection Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-30 Luís Almeida, Ayesha Dhillon-LaBrooy, Tim Sparwasser
The function and phenotype of macrophages are intimately linked with pathogen detection. On sensing pathogen-derived signals and molecules, macrophages undergo a carefully orchestrated process of polarization to acquire pathogen-clearing properties. This phenotypic change must be adequately supported by metabolic reprogramming that is now known to support the acquisition of effector function, but also
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Methylmalonic acid in aging and disease Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-28 Joanne Tejero, Felicia Lazure, Ana P. Gomes
Metabolic byproducts have conventionally been disregarded as waste products without functions. In this opinion article, we bring to light the multifaceted role of methylmalonic acid (MMA), a byproduct of the propionate metabolism pathway mostly commonly known as a clinical biomarker of vitamin B12 deficiency. MMA is normally present at low levels in the body, but increased levels can come from different
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Cardiac macrophage metabolism in health and disease Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-21 Benjamin J. Kopecky, Kory J. Lavine
Cardiac macrophages are essential mediators of cardiac development, tissue homeostasis, and response to injury. Cell-intrinsic shifts in metabolism and availability of metabolites regulate macrophage function. The human and mouse heart contain a heterogeneous compilation of cardiac macrophages that are derived from at least two distinct lineages. In this review, we detail the unique functional roles
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Regulated cell death in myocardial ischemia–reperfusion injury Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-17 Qi Xiang, Xin Yi, Xue-Hai Zhu, Xiang Wei, Ding-Sheng Jiang
Myocardial ischemia–reperfusion (I/R) injury most commonly occurs in coronary artery disease when prompt reperfusion is used to salvage the ischemic myocardium. Cardiomyocyte death is a significant component of myocardial I/R injury and its mechanism was previously thought to be limited to apoptosis and necrosis. With the discovery of novel types of cell death, ferroptosis, necroptosis, and pyroptosis
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Lipodystrophy as a target to delay premature aging Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-15 Daniela G. Costa, Marisa Ferreira-Marques, Cláudia Cavadas
Lipodystrophy syndromes are rare diseases characterized by low levels and an abnormal distribution of adipose tissue, caused by diverse genetic or acquired causes. These conditions commonly exhibit metabolic complications, including insulin resistance, diabetes, hypertriglyceridemia, nonalcoholic fatty liver disease, and adipose tissue dysfunction. Moreover, genetic lipodystrophic laminopathies exhibit
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Advisory Board and Contents Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-14
Abstract not available
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Subscription and Copyright Information Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-14
Abstract not available
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Lipid metabolism reprogramming in cardiac fibrosis Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-08 Li-Chan Lin, Zhi-Yan Liu, Jing-Jing Yang, Jian-Yuan Zhao, Hui Tao
Cardiac fibrosis is a critical pathophysiological process that occurs with diverse types of cardiac injury. Lipids are the most important bioenergy substrates for maintaining optimal heart performance and act as second messengers to transduce signals within cardiac cells. However, lipid metabolism reprogramming is a double-edged sword in the regulation of cardiomyocyte homeostasis and heart function
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Maternal nutritional programming shapes the cerebral landscape Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-08 Bandy Chen, Elisa de Launoit, Nicolas Renier, Marc Schneeberger
The escalating prevalence of maternal obesity raises concerns about its influence on offspring health. Exposure to obesogenic environments during early development leads to persistent alterations in brain function contributing to neurological disorders. Nutritional programming emerges as a promising avenue to counteract the deleterious effects of maternal obesity on offspring neurodevelopment.
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Immunometabolic biomarkers for partial remission in type 1 diabetes mellitus Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-08 Laia Gomez-Muñoz, Juan Dominguez-Bendala, Ricardo L. Pastori, Marta Vives-Pi
Shortly after diagnosis of type 1 diabetes mellitus (T1DM) and initiation of insulin therapy, many patients experience a transient partial remission (PR) phase, also known as the honeymoon phase. This phase presents a potential therapeutic opportunity due to its association with immunoregulatory and β cell-protective mechanisms. However, the lack of biomarkers makes its characterization difficult.
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Shaping microbiome function with a human milk-oligosaccharide synbiotic Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-07 Ethel Closa, Loudon Herold, Matthew T. Sorbara
In a recent article, Button and colleagues demonstrate that human milk oligosaccharides create a nutrient niche that supports reversible colonization by Bifidobacterium infantis. Using this tunable system, they assessed the impact of B. infantis on microbiome recovery after antibiotic treatment. Overall, this work highlights synbiotics as a useful approach for developing live biotherapeutic products
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Mechanisms of hepatic fatty acid oxidation and ketogenesis during fasting Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-11-06 Philip M.M. Ruppert, Sander Kersten
Fasting is part of many weight management and health-boosting regimens. Fasting causes substantial metabolic adaptations in the liver that include the stimulation of fatty acid oxidation and ketogenesis. The induction of fatty acid oxidation and ketogenesis during fasting is mainly driven by interrelated changes in plasma levels of various hormones and an increase in plasma nonesterified fatty acid
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Common and divergent molecular mechanisms of fasting and ketogenic diets Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-10-28 Antonio Paoli, Grant M. Tinsley, Mark P. Mattson, Immaculata De Vivo, Ravi Dhawan, Tatiana Moro
Intermittent short-term fasting (ISTF) and ketogenic diets (KDs) exert overlapping but not identical effects on cell metabolism, function, and resilience. Whereas health benefits of KD are largely mediated by the ketone bodies (KBs), ISTF engages additional adaptive physiological responses. KDs act mainly through inhibition of histone deacetylases (HDACs), reduction of oxidative stress, improvement
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Ion homeostasis in diabetic kidney disease Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-10-23 Hongtu Hu, Wei Liang, Guohua Ding
The complications of type 2 diabetes are a major global public health problem with high incidence and mortality, affecting almost all individuals with diabetes worldwide. Diabetic kidney disease (DKD) is one such primary complication and has become a leading cause of end-stage renal disease in patients with diabetes. Progression from diabetes to DKD is a complex process typically involving multiple
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The gut–Snhg9 interplay as a new path to metabolic health Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-10-23 Jie Chen, Xian Chen, Jiangtao Gao
Parsing the intricate interplay between gut microbiota, gene modulation, and host metabolism remains challenging. Wang et al. employed diverse methods to uncover how the gut microbiota reshapes intestinal lipid metabolism through the lncRNA Snhg9, underscoring the value of systems biology approaches in dissecting host–microbiome relationships involved in metabolic disorders.
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The ticking of aging clocks Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-10-23 Jing-Dong J. Han
Computational models that measure biological age and aging rate regardless of chronological age are called aging clocks. The underlying counting mechanisms of the intrinsic timers of these clocks are still unclear. Molecular mediators and determinants of aging rate point to the key roles of DNA damage, epigenetic drift, and inflammation. Persistent DNA damage leads to cellular senescence and the s
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Hallmarks of the metabolic secretome Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-10-14 Saranya C. Reghupaty, Nicholas R. Dall, Katrin J. Svensson
The identification of novel secreted factors is advancing at an unprecedented pace. However, there is a critical need to consolidate and integrate this knowledge to provide a framework of their diverse mechanisms, functional significance, and inter-relationships. Complicating this effort are challenges related to nonstandardized methods, discrepancies in sample handling, and inconsistencies in the
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Subscription and Copyright Information Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-10-10
Abstract not available
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Advisory Board and Contents Trends Endocrin. Met. (IF 10.9) Pub Date : 2023-10-10
Abstract not available