BACKGROUND This study investigated the association of inflammatory markers in saliva, plasma, and cerebrospinal fluid (CSF) with cognitive decline and periodontitis. METHODS Patients with Alzheimer disease (AD, n = 52), mild cognitive impairment (MCI, n = 51), subjective cognitive decline (SCD, n = 51), and controls (n = 76) between 50 and 80 years were included. Participants underwent an oral

Background A randomized, controlled trial was conducted to evaluate the effectiveness of two supportive periodontal care (SPC) approaches in patients with periodontitis and to evaluate possible predictors influencing bleeding on probing (BoP) changes at 24‐month follow‐up. Methods Fifty‐six periodontitis patients who first received active periodontal treatment by means of quadrant‐wise subgingival

Background Patients with periodontitis can exhibit persistent periodontal pockets with bleeding representative of inflammation. This clinical study aimed to evaluate the effectiveness of a chitosan brush in improving residual periodontal pockets in patients who had already undergone causative therapy for periodontitis. Methods Thirty‐six patients with stage III or IV periodontitis, showing residual

Background Numerous studies have reported an association between depression and periodontitis, though results are inconsistent and highly heterogeneous. The present study aimed to examine the potential confounding role of poor socioeconomic status (SES) in the association between depression and periodontitis by performing a secondary analysis of the National Health and Nutrition Examination Survey

Background The identification of molecular biomarkers that help clinicians in early diagnosis is a key focus of periodontal research. The major aim of this cross‐sectional observational study was to assess whether salivary TAM pathway protein levels have the potential to discriminate between periodontally healthy or gingivitis controls and periodontitis patients, including those with mild (I/II) or

Background There is demand for new biomaterials that reduce the morbidity associated with a second graft site needed for autologous bone grafting and facilitate the surgical procedure. Here we compared bone volume gain using a supercritical CO 2 ‐processed allogeneic bone paste and bone powder in partially edentulous patients requiring bone augmentation of alveolar ridges by guided bone regeneration

Background Direct comparative data on periodontal regeneration (PR) versus extraction and implant placement remain limited. Tooth‐specific periodontal conditions such as furcation involvement and overall tooth prognosis may dictate success or failure of such treatment. Methods A retrospective analysis was conducted on patients undergoing periodontal regenerative procedures or dental implants at the

Background Emerging evidence indicates that oral health and metabolic dysfunction‐associated steatotic liver disease (MASLD) may be interconnected through shared genetic and metabolic pathways. However, the specific mechanisms underlying this association remains poorly understood. Methods This population‐based study included 478,000 participants from the UK Biobank (mean age: 56.5 years; 54.4% females)

Background A self‐reported questionnaire developed by the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP) has demonstrated adequate reliability for evaluating periodontal status in national surveillance surveys—–which has been translated and validated in multiple languages–—but has not yet been tested in Thai. Therefore, this cross‐sectional study evaluated

Background Periodontitis and major depression disorder have been shown to have a bidirectional association. However, the impact of antidepressants, the primary pharmacological treatment for depression, on periodontal health remains unclear. Given their anti‐inflammatory properties, antidepressants may exert a protective effect against periodontitis. This study aimed to investigate the association between

Background This study aimed to investigate the association between periodontitis severity and the risk of gestational diabetes mellitus (GDM) considering pathways induced by systemic inflammation. Methods Pregnant women with singleton pregnancies aged at least 18 years at 12–20 gestational weeks were enrolled in the study. Logistic and linear regression models were constructed to examine the associations

BackgroundThis study investigates how poor oral health impacts metabolic alterations, specifically evaluating the effects of periodontitis and tooth loss, either individually or in combination, on the number of metabolic syndrome (MetS) indicators.MethodsA cross‐sectional study was conducted with 1281 individuals aged 18 and older, attending public health clinics. Physical exams and laboratory tests

BackgroundAccumulation of senescent cells is increasingly recognized as a mechanism of aging and is considered an attractive therapeutic target for various age‐associated diseases. The prevalence and severity of periodontitis increase with age, and preclinical studies have demonstrated that senescent cells could be a potential therapeutic target for age‐associated periodontitis. However, clinical data

BackgroundThe association between periodontitis (PD) and rheumatoid arthritis (RA) has been linked to autoantibodies. In recent years, Arg‐gingipain (Rgp) triggered myeloperoxidase (MPO) release, which mediates protein carbamylation to form anti‐carbamylated proteins (anti‐CarP), perpetuating RA progression has gained interest. This study assessed the association between Rgp with MPO and anti‐CarP

BackgroundAlthough periodontitis and oral microbiota are linked to cardiometabolic diseases (CMD), it is unclear if they similarly predict CMD mortality. We compared the predictive ability of salivary microbiota and periodontal disease measures for CMD mortality in the National Health and Nutrition Examination Survey (NHANES).MethodsWe included 5,037 adults aged ≥30 years (mean age [± standard deviation

BackgroundHypoxia modulates inflammation and oxidative stress through hypoxia‐inducible factor‐1α (HIF‐1α). Ferroptosis, an iron‐dependent cell death process, is regulated by glutathione peroxidase‐4 (GPX4) and involves lipid peroxidation markers like malondialdehyde (MDA). This study evaluates HIF‐1α, GPX4, and MDA levels in peri‐implant crevicular fluid (PICF) across peri‐implant health, mucositis

BackgroundAccurate communication of periodontal stage and grade by general dentists in primary care is critical for patient understanding and engagement, yet patient retention and self‐reporting of this information upon referral to secondary care remains unclear.MethodsA total of 372 periodontal patients referred were informed about their diagnosis by their general dentists and then referred to secondary

BackgroundPeriodontitis and high phosphate (HP) intake can negatively affect the kidney in the presence of renal disease. This study aimed to evaluate the effects of periodontitis or HP intake, either alone or concurrently, on the periodontal tissue and the kidney under normal renal conditions.MethodsRats were divided into normal diet (C), HP diet (HP), tooth ligation and normal diet (P), and tooth

BackgroundBifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) is a probiotic bacterial strain with immunomodulatory properties. Its benefits have been observed in healthy and systemically compromised animals with periodontitis (PD). Our objective was to investigate the local and systemic effects of the systemic administration of B. lactis in pregnant rats with experimental periodontitis

BackgroundAccurate periodontal disease diagnosis is essential for optimal treatment planning and patient care. However, variability in applying the 2017 Periodontal Classification may affect diagnostic reliability and treatment outcomes. This study investigated diagnostic accuracy and consistency among periodontists, periodontal residents, and dental interns in Saudi Arabia.MethodsForty‐four participants

BackgroundRecent advancements in bone tissue biomarker research have identified 2 promising molecules: Dickkopf‐1 and secreted Frizzled‐Related Protein 5. This study aims to evaluate the levels of these biomarkers in gingival crevicular fluid in periodontal health, gingivitis, and periodontitis and to assess the effects of non‐surgical periodontal treatment on these biomarkers.MethodsA total of 99

BackgroundEvidence is emerging about the effects of a balanced nutrition in maintaining periodontal health. The aim of this project was to investigate the association between diet, severity of periodontitis, and periodontal and systemic inflammation.MethodsTwo hundred consecutive hospital patients underwent a full periodontal assessment, had blood samples taken, and filled out a food frequency questionnaire

BackgroundTitanium nanoparticle (TP) migration into peri‐implant bone may influence osseointegration. It remains unclear how loading protocols may affect TP distribution. This study aimed to detect TP in the bone around implants undergoing different loading protocols in Macaca fascicularis.MethodsNine histological samples containing 21 implants with two loading groups were analyzed. In the delayed‐loaded

BackgroundTo explore the effects and mechanisms of melatonin on orthodontically induced root resorption (OIIRR) by focusing its role on IL‐6 secretion in human periodontal ligament cells (hPDLCs).MethodsCytokine array was used to identify the key inflammatory cytokine secreted by hPDLCs under excessive compressive force. Western blot analysis and immunohistochemistry staining (IHC) were conducted to

BackgroundCD4+ T lymphocytes play a central role in the pathogenesis of periodontitis, with the Treg/Th17 (regulatory T cell/T helper 17 cell) imbalance closely linked to diabetes‐associated periodontitis (DPD). Maxacalcitol (OCT), an analog of active vitamin D, has therapeutic effects on diseases involving Treg/Th17 imbalance. This study aimed to determine whether OCT improved DPD by restoring the

BackgroundDespite growing interest in dentofacial interactions, evidence linking three‐dimensional (3D) craniofacial morphology to periodontal phenotypes remains sparse. This cross‐sectional study aimed to investigate correlations between maxillary anterior periodontal parameters and 3D craniofacial morphology in a Chinese population.MethodsParticipants underwent cone‐beam computed tomography (CBCT)

BackgroundThe aim of this study was to study the effect of non‐surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) and serum progranulin (PGRN) levels in the early healing phases.MethodsThe study included periodontitis (test) (n = 24) and periodontal health (control) (n = 24) groups. PGRN, vascular endothelial growth factor (VEGF), interleukin (IL)‐1β, tumor necrosis factor alpha

BackgroundInflammatory cytokines play a significant role in the pathogenesis of both autoimmune hypothyroidism and periodontal disease. The cumulative effect of these inflammatory markers may lead to extensive periodontal breakdown. This study was undertaken to assess the prevalence and severity of periodontitis, to correlate clinical attachment loss (CAL), and periodontal inflamed surface area (PISA)

BackgroundThis study investigates the association of circadian rhythmicity, physical activity, and chronotype with periodontal diseases, focusing on both the independent and combined effects.MethodsA cross‐sectional study was conducted among 94,305 participants from the UK Biobank. Circadian rhythmicity, measured by relative amplitude from the accelerometer, was the primary exposure, with physical

BackgroundCollagen matrices (CMs) have been used for the treatment of gingival recession defects. A new volume‐stable collagen matrix (VCMX) was developed focused on enhancing tissue thickness due to a cross‐linked collagen structure. Thus, the present randomized clinical trial aims to evaluate clinical and patient‐centered parameters in the treatment of gingival recession (GR) RT1 associated with

BackgroundEvidence on the 16S metabarcoding of supragingival, subgingival, and salivary microbiomes in periodontal health remains limited. We aimed to analyze the diversity and potential of machine‐learning models of supragingival, subgingival, and salivary microbiomes in periodontal health.MethodsA total of 848 samples (supragingival = 210; subgingival = 155; saliva = 483) from 491 periodontally healthy

BackgroundLong noncoding RNAs (lncRNAs) are emerging regulators of periodontal inflammation. This study investigates the role of lncRNA MIR100HG in periodontitis and its interaction with the RNA‐binding protein Quaking (QKI).MethodsIn vitro, human gingival fibroblasts (HGFs) were stimulated with Porphyromonas gingivalis lipopolysaccharide (Pg.LPS, 200 ng/mL, 24 h). In vivo, ligature‐induced periodontitis

BackgroundThe relationship between periodontitis and erectile dysfunction (ED) has been poorly documented in Caucasian populations, particularly severe ED (SED) requiring penile prostheses. This study aimed to evaluate the association between periodontitis and SED in patients undergoing penile prosthesis implantation, and to identify clinical and biochemical periodontal variables associated with SED

BackgroundCurrent evidence indicates a possible link between the design of the implant‐abutment‐prosthesis complex and the development of peri‐implant diseases. This cross‐sectional study aimed to investigate the association between implant and prosthetic factors and the prevalence of peri‐implant diseases and peri‐implant marginal bone loss in patients treated with static computer‐assisted implant

BackgroundThe study aimed to assess the impact of palatal pre‐suturing on bleeding, postoperative morbidity, wound healing, and quality of life following subepithelial connective tissue graft (SCTG) surgery through a randomized controlled clinical trial.MethodsThirty‐two healthy, non‐smoking participants (18–60 years) with a single Cairo type 1 or 2 gingival recession were randomly assigned to test

BackgroundThis study is part of a randomized controlled trial investigating the impact of soft tissue augmentation (STA) using subepithelial connective tissue graft (SCTG) (immediate implant with subepithelial connective tissue graft [ICT] group) or acellular dermal matrix (ADM) (immediate implant with acellular dermal matrix [IAD] group) versus no STA (control) on the clinical outcomes following immediate

BACKGROUND To examine whether the associations between periodontitis and multiple systemic conditions increase with increasing severity of periodontitis using a multi-center electronic health record (EHR) repository. METHODS A cross-sectional analysis was conducted using EHR data from 9 dental schools in the United States. We included 264,913 adults (≥18 years) receiving periodontal therapy between

BackgroundPulsed electromagnetic field (PEMF) therapy, renowned for its immunomodulatory effects and established efficacy in orthopedics, shows promise for managing peri‐implantitis by reducing soft tissue inflammation and marginal bone loss. This study aimed to compare the long‐term clinical and radiographic outcomes of nonsurgical peri‐implantitis treatment with and without PEMF therapy. This multicenter

BackgroundPrecise assessment of anatomical variations and alveolar bone configurations (ABCs) in permanent mandibular first molars (PMFMs) is crucial for effective periodontal treatment. This cross‐sectional study aimed to evaluate the prevalence of disto‐lingual roots (DLRs) and ABCs in PMFMs and investigate the correlation between DLRs and clinical parameters related to ABCs at the distal aspect

BackgroundHerein, we aimed to identify factors associated with tooth loss over a 9‐ to 11‐year period in young individuals with periodontitis, with a specific focus on the impact of patient compliance. The secondary outcome was to identify factors associated with discontinuation of active periodontal treatment.MethodsThis retrospective register‐based cohort study included 446 patients under the age

BackgroundSelf‐reported data can extend the reach of oral health research, but “Don't know” responses may threaten validity. We explored characteristics of participants who responded “Don't know” to a periodontal health question across three distinct cohorts.MethodsWe used data from three questionnaire‐based observational studies, namely, the Pregnancy Study Online (PRESTO) (N = 10,996), the Black

BackgroundType 2 diabetes (T2DM) and periodontitis have been suggested as risk factors for dental implant failure, but data supporting such a link are limited. This study investigates the association between T2DM and periodontitis and the risk of dental implant failure.MethodsA nested case‐control study with a risk‐set sampling scheme was performed. Implant failure cases (550 failed implants in 328

BackgroundWhile several studies have compared the performance of alveolar ridge preservation (ARP) using different bone substitutes in terms of histological outcomes and maintenance of ridge dimensions, there is a lack of data comparing implant outcomes in ARP‐treated sites with different grafts. The aim of this retrospective cohort study was to compare the performance of dental implants placed in

BackgroundAllografts and xenografts are viable options for alveolar ridge preservation. This study evaluated histologic wound healing when using demineralized freeze‐dried bone allograft (DFDBA) alone, in fiber or particulate form, and in combination with xenograft. Alveolar dimensional changes were also evaluated.MethodsThis four‐arm, parallel, randomized controlled trial included 120 patients with

BackgroundPeri‐implantitis, an inflammatory condition occurring in the supportive tissues, is triggered by a dysbiotic biofilm that grows on implant and/or abutment surfaces. Consequently, the entire surface becomes a notorious culprit, fostering bacterial adhesion that might lead to progressive loss of supporting bone. To combat peri‐implantitis, research groups worldwide have diligently pursued the

BACKGROUND The primary objective of this study is to evaluate the accuracy of 3-dimensional (3D) imaging in detecting radiographic and morphological graft changes compared to traditional 2-dimensional (2D) imaging. Additionally, the study aims to assess the distribution of graft material and the extent of resorption occurring between baseline and 6 months post-implant placement following transcrestal

BACKGROUND This study aimed to provide an updated assessment of the global, regional, and national burden of oral disorders from 1990 to 2021, and forecast trends for the next 30 years. METHODS Data on incidence, prevalence, and disability-adjusted life years (DALYs) were extracted from the Global Burden of Diseases(GBD) 2021. The changing trends in the burden of oral disorders and subtypes were

BackgroundPeriodontitis is a chronic inflammatory condition that leads to progressive destruction of the alveolar bone. Currently, there is a lack of effective adjuvant treatments to nonsurgical periodontal therapy offering strong antiresorptive properties. Tanshinone IIA (T‐IIA), a lipophilic compound derived from Salvia miltiorrhiza, exhibits various biological properties. This study investigates

BackgroundPeriodontitis, an inflammatory condition, results from the immune response to pathogenic microorganisms. Gingival defects from periodontitis enable these microorganisms, along with immune cells and inflammatory proteins, to enter the bloodstream, potentially causing systemic inflammation and contributing to systemic diseases. Conversely, systemic diseases can worsen periodontitis by inducing

BackgroundThe present study aimed to investigate the expression of stromal cell‐derived factor‐1 (SDF‐1) after tooth extraction in rats and its regulatory effect on the expression of osteopontin (OPN) and vascular endothelial growth factor (VEGF).MethodsThe first mandibular molar of the rats on the left was extracted, the histopathological changes of the extraction sockets were observed, and the SDF‐1

BackgroundSinus membrane perforations occasionally occur during sinus lifting procedures. This study utilized rhesus monkey models to compare the effectiveness of two techniques (pouch and non‐pouch methods) in repairing large perforations, with a focus on their impact on bone regeneration.MethodsIn five male rhesus monkeys, both sides of the sinus membrane were elevated and perforated. Each sinus

BackgroundIsovaleric acid, an important short‐chain fatty acid, can be generated by subgingival microbial fermentation of a leucine‐rich diet, such as Porphyromonas gingivalis. This study aimed to explore the impact of isovaleric acid on the destruction of periodontal tissues and to investigate the underlying mechanisms.MethodsThe level of isovaleric acid in the saliva of clinical subjects was measured

BackgroundOral polymorphonuclear neutrophil (oPMN) levels are potential biomarkers for differentiating between stages and grades of periodontitis. We compared the diagnostic utility of oPMN levels with bleeding on probing percentage (BOP%) and microbial load in high‐risk patients with periodontitis.MethodsSixty‐two subjects were divided into four categories based on periodontitis stage and grade: stage

BackgroundThis study assessed how prenatal probiotic (P) supplementation affected the development of experimental periodontitis (PE) in pregnant mice, as well as the anthropometric traits of the resulting fetuses and the placental and intestinal tissues of the mother.MethodsThirty‐two pregnant mice in all were divided into four groups (n = 8): Experimental periodontitis (PE), Experimental Periodontitis

BackgroundOligodontia is a rare condition characterized by the absence of at least 6 teeth. Implant‐supported prosthetic rehabilitation offers a reliable solution for affected patients. However, the unique periodontal traits of oligodontia raise questions about the best prosthetic approach for papilla reconstruction. This retrospective study aims to assess papilla and gingival esthetics in implant‐supported