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Better living through chemistry? A randomized, double-blind controlled study evaluating the efficacy of plaque control and gingival health impacts of a novel stannous fluoride-containing gel J. Periodontol. (IF 4.494) Pub Date : 2022-08-18 Thair Takesh, Arezou Goshtasbi, Kairong Lin, Susan Meishan Yang, Cherie Wink, Maria L. Geisinger, Petra Wilder-Smith
: Gingivitis is a non-specific inflammatory lesion in response to accumulation of oral biofilm and is a necessary precursor to periodontitis. Enhanced oral hygiene practices are necessary to reverse gingivitis and a dentifrice that could provide significant clinical reductions in plaque accumulation and gingival inflammation would be desirable to treat gingivitis and potentially prevent progression
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Serum antibodies to periodontal pathogens are related to allergic symptoms J. Periodontol. (IF 4.494) Pub Date : 2022-08-12 Mi Du, Shulan Xu, Bingjiang Qiu, Shixian Hu, Geerten-Has E. Tjakkes, An Li, Shaohua Ge
: The association between periodontitis and allergic symptoms has been investigated. However, the difference in immune signatures between them remains poorly understood. This cross-sectional study assessed the relationship between serum immunoglobulin G (IgG) antibodies to periodontal pathogens and allergic symptoms in a nationwide population cohort.
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The effect of bone particle size on the histomorphometric and clinical outcomes following lateral ridge augmentation procedures. A randomized double blinded controlled trial. J. Periodontol. (IF 4.494) Pub Date : 2022-08-12 Hussein S Basma,Muhammad H A Saleh,Nico C Geurs,Peng Li,Andrea Ravidà,Hom-Lay Wang,Ramzi V Abou-Arraj
BACKGROUND The aim of this randomized clinical trial was to clinically and histologically compare the amount and quality of bone gained after lateral ridge augmentation (LRA) procedures performed using small (250-1000μm) versus large (1000-2000μm) particle size cortico-cancellous bone allografts at 6 months following surgical intervention. MATERIALS AND METHODS 22 patients, each presenting with ridge
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Epidemiological and sociodemographic transitions of severe periodontitis incidence, prevalence and disability-adjusted life years for 21 world regions and globally from 1990 to 2019: An Age-Period-Cohort Analysis J. Periodontol. (IF 4.494) Pub Date : 2022-08-08 Yiran Cui, Gang Tian, Ri Li, Yan Shi, Tong Zhou, Yan Yan
: Severe periodontitis is the most prevalent disease of all conditions and a global public health problem. This is because of its high incidence and prevalence. However, there are few studies on the burden of periodontitis in different regions of the world.
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High prevalence of periodontitis in children and adolescents with type 2 diabetes mellitus J. Periodontol. (IF 4.494) Pub Date : 2022-08-06 Sylvia MC Todescan, Robert J. Schroth, Heather Dean, Brandy Wicklow, Edgard Michel-Crosato, Elizabeth Sellers
to determine the prevalence of periodontitis and if poor glycemic control is associated with increasing prevalence of the disease.
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Flap versus flapless alveolar ridge preservation: A clinical and histological single-blinded, randomized controlled trial J. Periodontol. (IF 4.494) Pub Date : 2022-08-04 Trever L. Siu, Himabindu Dukka, Muhammad H.A. Saleh, Mustafa Tattan, Ziad Dib, Andrea Ravidà, Henry Greenwell, Hom-Lay Wang, Mauricio G. Araujo
: The aim of this randomized clinical trial was to compare a flapless technique of alveolar ridge preservation (ARP) to a flap technique, to determine if preserving the periosteal blood supply would limit loss of crestal ridge width and height.
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M2 macrophages with inflammation tropism facilitate cementoblast mineralization J. Periodontol. (IF 4.494) Pub Date : 2022-08-01 Xin Huang, Xiaoxuan Wang, Li Ma, Huiyi Wang, Yan Peng, Heyu Liu, Junhong Xiao, Zhengguo Cao
Cementum regeneration was regarded as the critical goal for periodontal regeneration. M2 macrophage-based therapy was expected to be a promising strategy for it. However, little is known about the effects of M2 macrophages on cementoblast mineralization and tropism, especially under inflammation. Here we first investigated the crosstalk between M2 macrophages and porphyromonas gingivalis (P. gingivalis)-stimulated
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Hertwig's Epithelial Root Sheath Cells Show Potential for Periodontal Complex Regeneration J. Periodontol. (IF 4.494) Pub Date : 2022-08-01 Fei Bi, Huilin Tang, Zhijun Zhang, Yun Lyu, Fangjun Huo, Guoqing Chen, Weihua Guo
Though researchers have been exploring therapeutic strategies of treating serious periodontal tissue loss including the application of stem cells, tissue regeneration of the periodontal complex involving cementum, periodontium and alveolar bone has hardly been achieved. Aiming at tackling the problem of severely damaged periodontal complex, it is worth trying to make advantages of Hertwig's epithelial
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Soft tissue augmentation with a volume-stable collagen matrix or an autogenous connective tissue graft at implant sites: 5-year results of a randomized controlled trial post implant loading J. Periodontol. (IF 4.494) Pub Date : 2022-07-29 Daniel S. Thoma, Thomas J. W. Gasser, Christoph H. F. Hämmerle, Strauss FJ, Ronald E. Jung
: Interventions to augment the mucosal thickness around dental implants are indicated to optimize aesthetics and maintain peri-implant health. However, there is a lack of clinical data on the long-term performance of soft tissue substitutes (VCMX) compared to autogenous grafts (SCTGs). The aim of the present randomized controlled trial was to assess 5-year data on clinical and radiographic outcomes
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Effect of supragingival plaque control on recurrent periodontitis and clinical stability among individuals under periodontal maintenance therapy: 10-year follow-up J. Periodontol. (IF 4.494) Pub Date : 2022-07-29 Fernando Oliveira Costa, Adriana Moreira Costa, José Roberto Cortelli, Sheila Cavalca Cortelli, Amanda Almeida Costa, Rafael Paschoal Esteves Lima, Gustavo Henrique Mattos Pereira, Alcione Maria Soares Dutra Oliveira, Peterson Antônio Dutra Oliveira, Luís Otávio Miranda Cota
The aim of the study was to evaluate the effect of supragingival plaque control on the recurrence of periodontitis (RP) and the achievement of a stable periodontal clinical endpoint after 10 years of periodontal maintenance therapy (PMT).
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Abaloparatide excels teriparatide in protecting against alveolar bone loss in experimental periodontitis J. Periodontol. (IF 4.494) Pub Date : 2022-07-26 Yuan Li, Yuran Qian, Hui Qiao, Weiyi Pan, Liang Xie, Yu Li
It was aimed to compare the effects of two osteoanabolic drugs, abaloparatide (ABL) and teriparatide (TPTD), on protecting alveolar bone in experimental periodontitis.
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Type I diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling J. Periodontol. (IF 4.494) Pub Date : 2022-07-23 Xue Yuan, Vedanshi Amin, Tianli Zhu, Mizuho Kittaka, Yasuyoshi Ueki, Teresita M. Bellido, Hakan Turkkahraman
Type I Diabetes Mellitus (T1DM) and periodontitis have long been thought to be biologically connected. Indeed, T1DM is a risk factor for periodontal disease. With the population of diabetic individuals growing, it's more important than ever to understand the negative consequences of diabetes on the periodontium and the mechanisms. The aim of this study was to find out the early effects of T1DM on the
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Microbiological effects of amoxicillin plus metronidazole in the treatment of young patients with stages III and IV periodontitis: a secondary analysis from a 1-year double-blinded placebo-controlled randomized clinical trial J. Periodontol. (IF 4.494) Pub Date : 2022-07-23 Marcelo Faveri, Belen Retamal-Valdes, Maria Josefa Mestnik, Luciene Cristina de Figueiredo, Valentim Adelino Ricardo Barão, Joao Gabriel Silva Souza, Poliana Mendes Duarte, Magda Feres
: Despite the body of evidence supporting the clinical benefits of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of young patients with periodontitis, the microbiological outcomes of this antibiotic protocol have been less explored. This study evaluated the microbiological effects of adjunctive MTZ+AMX in the treatment of young patients with periodontitis.
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The causal effect of life course adiposity on periodontitis: A Mendelian randomization study J. Periodontol. (IF 4.494) Pub Date : 2022-07-21 Wenjing Li, Ying He, Qiwen Zheng, Xuliang Deng
To establish whether life course adiposity, including birth weight (BW), childhood and adulthood body mass index (BMI), waist–hip ratio (WHR), and body fat percentage (BF%), has a causal influence on periodontitis.
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Association between periodontal disease, tooth extraction, and medication-related osteonecrosis of the jaw in women receiving bisphosphonates: A national cohort-based study J. Periodontol. (IF 4.494) Pub Date : 2022-07-20 Min-Jeong Kwoen, Jung-Hyun Park, Keun-Suh Kim, Jae-Ryun Lee, Jin-Woo Kim, HyeJin Lee, Hyo-Jung Lee
We investigated whether periodontal diseases contribute to the development of medication-related osteonecrosis of the jaw (MRONJ) in addition to tooth extraction, which is a major risk factor for MRONJ occurrence.
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Efficacy of biologics for alveolar ridge preservation/reconstruction and implant site development: An American Academy of Periodontology best evidence systematic review J. Periodontol. (IF 4.494) Pub Date : 2022-07-16 Fernando Suárez-López del Amo, Alberto Monje
The use of biologics may be indicated for alveolar ridge preservation (ARP) and reconstruction (ARR), and implant site development (ISD). The present systematic review aimed to analyze the effect of autologous blood-derived products (ABPs), enamel matrix derivative (EMD), recombinant human platelet-derived growth factor-BB (rhPDGF-BB), and recombinant human bone morphogenetic protein-2 (rhBMP-2), on
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Baseline interleukin-10, CD163 and tumor necrosis factor-like weak inducer of apoptosis gingival tissue levels in relation to clinical periodontal treatment outcomes: A 12-week follow-up study J. Periodontol. (IF 4.494) Pub Date : 2022-07-12 Mustafa Yilmaz, Esra Demir, Mervi Gürsoy, Erhan Firatli, Ulvi Kahraman Gürsoy
The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival tissue levels of M2 macrophage activation-related proteins CD163, interleukin (IL)-10, interferon (IFN)-γ, and tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and the CD163/TWEAK ratio.
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Retrospective exploratory study of smoking status and e-cigarette use with response to non-surgical periodontal therapy J. Periodontol. (IF 4.494) Pub Date : 2022-07-04 Chandni Shah, Birte Holtfreter, Francis J. Hughes, Luigi Nibali
To compare periodontal treatment responses in electronic cigarette (e-cigarette) users, non-smokers, former and current smokers.
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Antibody response to BNT162b2 mRNA vaccine in gingival crevicular fluid J. Periodontol. (IF 4.494) Pub Date : 2022-06-30 Pingping Han, Corey S. Moran, Srinivas Sulugodu Ramachandra, Laurence J. Walsh, Sašo Ivanovski
This prospective cohort study aimed to evaluate the antibody responses in non-invasive gingival crevicular fluid (GCF) and unstimulated whole saliva to the SARS-CoV-2 Spike unit 1 receptor-binding domain (S1-RBD) protein following administration of the mRNA BNT162b2 vaccine.
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Patient-reported outcomes of palatal donor site healing using four different wound dressing modalities following free epithelialized mucosal grafts: A four-arm randomized controlled clinical trial J. Periodontol. (IF 4.494) Pub Date : 2022-06-26 Hussein S. Basma, Muhammad H. A. Saleh, Ramzi V. Abou-Arraj, Matthew Imbrogno, Andrea Ravida, Hom-Lay Wang, Peng Li, Nicolaas Geurs
The aim of this study was to compare the effects of four different commonly used wound dressings in improving patient reported outcomes (PROMS) after free epithelialized mucosal grafts (FEGs) harvesting.
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Circulating small extracellular vesicles from patients with periodontitis contribute to development of insulin resistance J. Periodontol. (IF 4.494) Pub Date : 2022-06-18 Fei Wang, Linlin Peng, Fan Gu, Pei Huang, Bo Cheng, Gang Chen, Liuyan Meng, Zhuan Bian
Epidemiological studies have identified the role of periodontitis in the pathogenesis of type 2 diabetes, but the underlying mechanism is poorly understood. It is well-known that small extracellular vesicles are lipid bilayer vesicles derived from cells with a diameter around 30 to 200 nm. The purpose of this study was to investigate whether periodontitis induced or exacerbated insulin resistance via
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Proportional relationship between periodontal inflamed surface area, clinical attachment loss, and glycated hemoglobin level in patients with type 2 diabetes mellitus on insulin therapy and on oral antidiabetic therapy J. Periodontol. (IF 4.494) Pub Date : 2022-06-18 Simna Pattayil, Rosamma Joseph Vadakkekuttical, Chandni Radhakrishnan, Harikumar Kanakkath, Thayyil Sivaraman Hrishi
Treatment of diabetes includes oral antidiabetic drugs (OAD), insulin, or their combinations. Insulin can achieve faster glycemic control and have anabolic action on bone. This study was undertaken to assess the prevalence and severity of periodontitis, and to estimate the proportional relationship between periodontal inflamed surface area, clinical attachment loss, and glycated hemoglobin (HbA1c)
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Regulation of gingival keratinocyte monocyte chemoattractant protein-1-induced protein (MCPIP)-1 and mucosa-associated lymphoid tissue lymphoma translocation protein (MALT)-1 expressions by periodontal bacteria, lipopolysaccharide, and interleukin-1β J. Periodontol. (IF 4.494) Pub Date : 2022-06-17 Yigit Firatli, Erhan Firatli, Vuokko Loimaranta, Samira Elmanfi, Ulvi K. Gürsoy
The aim of this study was to evaluate oral bacteria- and interleukin (IL)-1β-induced protein and mRNA expression profiles of monocyte chemoattractant protein-1-induced protein (MCPIP)-1 and mucosa-associated lymphoid tissue lymphoma translocation protein (MALT)-1 in human gingival keratinocyte monolayers and organotypic oral mucosal models.
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Prevalence of periodontal disease in young Moroccans: A national survey J. Periodontol. (IF 4.494) Pub Date : 2022-06-16 Jamila Kissa, Bouchra El Houari, Khadija Amine, Sihame Chemlali, Nadia Khlil, Salwa Mikou, Amina Gharibi, Imane El Ouadnassi, Chouaib Rifki, Jasim M. Albandar
There are few large surveys of periodontal disease in young age cohorts, and national surveys in Africa do not exist. This study assessed the prevalence and severity of periodontal disease in a national survey of adolescents and young adults in Morocco.
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Impact of scaling and root planing on salivary and serum plasminogen activator inhibitor-1 expression in patients with periodontitis with and without type 2 diabetes mellitus J. Periodontol. (IF 4.494) Pub Date : 2022-06-16 Sanjeela R. Guru, Suchetha Aghanashini
Plasminogen activator inhibitor-1 (PAI-1) is significantly enhanced in insulin resistance and inflammation and ascribed as a proinflammatory marker. This study aimed to compare and correlate salivary and serum PAI-1 and alpha 2-macroglobulin (α2MG) in patients with periodontitis with and without type 2 diabetes mellitus (T2DM) and also appraise the consequence of periodontal treatment on these biomarkers
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Probiotic consumption can modify the resilience of periodontal tissues in rats under experimental periodontitis J. Periodontol. (IF 4.494) Pub Date : 2022-06-12 Luiz Fernando Ferreira de Oliveira, Pedro Henrique Felix Silva, Sergio Luiz Salvador, Edilson Ervolino, Renato Casarin, Luciene Figueiredo, Milla Tavares Ricoldi, Sérgio Luís Scombatti de Souza, Flavia Furlaneto, Michel Reis Messora
: This study evaluated the effects of systemic administration of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) on experimental periodontitis (EP) in rats.
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Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats J. Periodontol. (IF 4.494) Pub Date : 2022-06-09 Jorge Toledano-Serrabona, Octavi Camps-Font, Diogo Pompéu de Moraes, Mario Corte-Rodríguez, María Montes-Bayón, Eduard Valmaseda-Castellón, Cosme Gay-Escoda, M. Ángeles Sánchez-Garcés
The objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris.
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Association between periodontitis and peripheral markers of innate immunity activation and inflammation J. Periodontol. (IF 4.494) Pub Date : 2022-06-06 José Dopico, João Botelho, Alberto Ouro, Clara Domínguez, Vanessa Machado, Marta Aramburu-Nuñez, Antía Custodia, Teresa Blanco, María Vázquez-Reza, Daniel Romaus-Sanjurjo, Juan Blanco, Rogelio Leira, Tomás Sobrino, Yago Leira
Immune response leading to increased systemic inflammation is one of the mechanisms linking periodontitis to chronic inflammatory diseases. The aim of this study was to compare the expression of toll-like receptors 2 and 4 in monocytes and neutrophils (TLR2M, TLR2N, TLR4M, and TLR4N) and its endogenous ligands (cellular fibronectin [cFN] and heat shock protein 60 [HSP60]) in patients with and without
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Evaluation of periodontal status and cytokine levels in saliva and gingival crevicular fluid of patients with inflammatory bowel diseases J. Periodontol. (IF 4.494) Pub Date : 2022-06-05 Ayaz Enver, Nurdan Ozmeric, Sila Cagri Isler, Murat Toruner, Cigdem Fidan, Gulsah Demirci, Serenay Elgun, Andre Paes B. da Silva
Periodontal diseases and inflammatory bowel diseases (IBD, ulcerative colitis [UC] and Crohn disease [CD]) have been reported to present with increased salivary and gingival crevicular fluid (GCF) concentrations of cytokines. The aim of this study was to evaluate the salivary and GCF levels of TNF-α, IL-1β, IL-10, and IL-17A and their associations with the periodontal statuses of UC, CD, and non-IBD
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New evidences of genetic heterogeneity of causing hereditary gingival fibromatosis and ALK and CD36 as new candidate genes J. Periodontol. (IF 4.494) Pub Date : 2022-06-04 Renato Assis Machado, Rodrigo Soares de Andrade, Sabina Pena Borges Pêgo, Ana Cristina Victorino Krepischi, Ricardo D. Coletta, Hercílio Martelli-Júnior
Hereditary gingival fibromatosis (HGF) is an uncommon genetic condition characterized by slow but progressive fibrous, non-hemorrhagic, and painless growth of the gingival tissues due to the increased deposition of collagen and other macromolecules of the extracellular matrix. HGF occurs in approximately 1:750,000 individuals and can exhibit dominant or recessive inheritance. To date, five loci (2p21-p22
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Comparing the histological assessment following ridge preservation using a composite bovine-derived xenograft versus an alloplast hydroxyapatite-sugar cross-linked collagen matrix J. Periodontol. (IF 4.494) Pub Date : 2022-06-04 Alicia Casarez-Quintana, Brian L. Mealey, Georgios Kotsakis, Archontia Palaiologou
This randomized controlled trial was designed to evaluate the histological wound healing and alveolar ridge dimensional changes following ridge preservation using two different xenograft/collagen matrices.
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Depth of mucosal tunnel in peri-implant health during 12-month follow-up in patients with controlled periodontitis J. Periodontol. (IF 4.494) Pub Date : 2022-06-04 Cho-Ying Lin, Pe-Yi Kuo, Meng-Yao Chiu, Hom-Lay Wang
The association between thickness of peri-implant mucosa, known as mucosal tunnel (MT) and related clinical parameters in bone-level implants has not been investigated.
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Canonical Wnt/β-catenin signaling has positive effects on osteogenesis, but can have negative effects on cementogenesis J. Periodontol. (IF 4.494) Pub Date : 2022-06-01 Tiancheng Li, Han Wang, Yukun Jiang, Yuzhe Guan, Shuo Chen, Zuping Wu, Shujuan Zou, Lynda Faye Bonewald, Peipei Duan
To date, therapeutic approaches for cementum regeneration are limited and outcomes remain unpredictable. A significant barrier to improve therapies for cementum regeneration is that the cementocyte and its intracellular signal transduction mechanisms remain poorly understood. This study aims to elucidate the regulatory mechanism of Wnt pathway in cementogenesis.
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Fusobacterium nucleatum mediates endothelial damage and increased permeability following single species and polymicrobial infection J. Periodontol. (IF 4.494) Pub Date : 2022-05-29 Cher Farrugia, Graham P. Stafford, Ashley F. Gains, Antonia R. Cutts, Craig Murdoch
Numerous lines of evidence link periodontal pathobionts and their virulence factors with endothelial damage. Most research has been conducted using single species infections at the exclusion of other periodontal microorganisms that have been identified in vascular tissue. Here, we assessed endothelial infection with either single or mixed periodontal species infection and examined their effect on endothelial
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Effect of locally applied simvastatin on clinical attachment level and alveolar bone in periodontal maintenance patients: Randomized clinical trial J. Periodontol. (IF 4.494) Pub Date : 2022-05-27 Amy C. Killeen, Lauren E. Krell, Mattie Bertels, Mary M. Christiansen, Laura Anderson, Robin L. Hattervig, Kaeli K. Samson, Dong Wang, Richard A. Reinhardt
The purpose of this double-masked, randomized, controlled trial was to determine if the local application of simvastatin (SIM), combined with minimally invasive papilla reflection and root planing (PR/RP), is effective in improving clinical attachment level (CAL), probing depth (PD) reduction, and increasing interproximal bone height (IBH) in persistent 6–9 mm periodontal pockets in patients receiving
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Relationship between periodontitis and risk of cardiovascular disease: Insights from the Tromsø Study J. Periodontol. (IF 4.494) Pub Date : 2022-05-27 Natalia Petrenya, Laila Arnesdatter Hopstock, Gro Eirin Holde, Nils Oscarson, Birgitta Jönsson
Few large-scale studies have investigated the association between periodontitis and cardiovascular risk estimated by risk assessment models; moreover, this association remains unexplored in never-smokers. We aimed to examine the relationship between periodontitis and cardiovascular risk in a Norwegian general population, with a focus on never-smokers and the impact of sex and age.
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M101, a therapeutic oxygen carrier derived from Arenicola marina, decreased Porphyromonas gingivalis- induced hypoxia and improved periodontal healing J. Periodontol. (IF 4.494) Pub Date : 2022-05-10 Fareeha Batool, Catherine Petit, Céline Stutz, Hayriye Özçelik, Pierre-Yves Gegout, Nadia Benkirane-Jessel, Eric Delpy, Franck Zal, Elisabeth Leize-Zal, Olivier Huck
Porphyromonas gingivalis exacerbates tissue hypoxia and worsens periodontal inflammation. This study investigated the effect of a therapeutic oxygen carrier (M101), derived from Arenicola marina, on hypoxia and associated inflammation in the context of periodontitis.
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Is the degree of physiological bone remodeling a predictive factor for peri-implantitis? J. Periodontol. (IF 4.494) Pub Date : 2022-05-10 Maria Vera Rodriguez, Andrea Ravidà, Muhammad H.A. Saleh, Hussein S. Basma, Himabindu Dukka, Hadiya Khurshid, Hom-Lay Wang, Pablo Galindo Moreno
The amount of initial physiological bone remodeling (IPBR) after implant placement varies and the ways it may play a role in peri-implantitis development remains unknown. The aim of this retrospective study was to investigate the association between the amount of IPBR during the first year of implant placement and incidence of peri-implantitis as well as the pattern of progressive bone loss.
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Open flap debridement compared to repeated applications of photodynamic therapy in the treatment of residual pockets: A randomized clinical trial J. Periodontol. (IF 4.494) Pub Date : 2022-05-10 Naira M. R. B. Andere, Nídia C. Castro dos Santos, Cássia F. Araújo, Hélvis E. S. Paz, Luciana M. Shaddox, Renato C. V. Casarin, Mauro P. Santamaria
The aim of the present study was to compare repeated applications of antimicrobial photodynamic therapy (aPDT) to open flap debridement (OFD) in the treatment of residual periodontal pockets in non-furcation sites.
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Relationship between the subgingival microbiome and menopausal hormone therapy use: The Buffalo OsteoPerio study J. Periodontol. (IF 4.494) Pub Date : 2022-05-09 Ahmed I. Soliman, Michael J. LaMonte, Kathleen M. Hovey, Daniel I. McSkimming, Chris A. Andrews, Patricia I. Diaz, Michael J. Buck, Yijun Sun, Amy E. Millen, Jean Wactawski-Wende
This study investigated the association between menopausal hormone therapy (HT) use and the subgingival microbiome, for which published information is limited.
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Stability of contour augmentation of implant-supported single crowns in the esthetic zone: One-year cone-beam computed tomography results of a comparative, randomized, prospective, two-center clinical study using two different bone grafting techniques in early implant placement J. Periodontol. (IF 4.494) Pub Date : 2022-05-04 Yu-Ling Tsai, Jui-Pin Tsao, Chung-Li Wang, Evan Grodin, Jung-Jen Lin, Chun-Jung Chen, Chung-Han Ho, David Cochran, Jimmy Lian Ping Mau
Early implant placement with contour augmentation could provide support and volume to the hard and soft tissues. Herein, we aimed to ascertain whether freeze-dried bone allograft (FDBA) shares with deproteinized bovine bone material (DBBM) the results for esthetic outcomes for anterior teeth and stability of peri-implant facial bone thickness and height by conducting guided bone regeneration.
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Apoptotic extracellular vesicles alleviate Pg-LPS induced inflammation of macrophages via AMPK/SIRT1/NF-κB pathway and inhibit adjacent osteoclast formation J. Periodontol. (IF 4.494) Pub Date : 2022-05-02 Qingyuan Ye, Haokun Xu, Shiyu Liu, Zihan Li, Jun Zhou, Feng Ding, Xige Zhang, Yazheng Wang, Yan Jin, Qintao Wang
Periodontitis is caused by the imbalance of anti-bacteria immune response and excessive inflammation whereas macrophages play an important role in inflammation. Thus, it is critical for finding efficient anti-inflammatory strategies to alleviate periodontal inflammation and prevent bone destruction. Apoptosis of mesenchymal stem cells (MSCs) exerts immune silencing effects, however, using these effects
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Influence of vestibular depth on the outcomes of root coverage therapy: A prospective case series study J. Periodontol. (IF 4.494) Pub Date : 2022-04-28 Gonzalo Blasi, Alberto Monje, Jesus Muñoz-Peñalver, Thomas W. Oates, Gustavo Avila-Ortiz, Jose Nart
The purpose of this study was to investigate the influence of vestibular depth (VD) on the outcomes of root coverage therapy.
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The additive effect of periodontitis with hypertension on risk of systemic disease and mortality J. Periodontol. (IF 4.494) Pub Date : 2022-04-23 Harriet Larvin, Jing Kang, Vishal R. Aggarwal, Sue Pavitt, Jianhua Wu
Recent evidence suggests that periodontitis (PD) causes hypertension, which is a precursor to development of other systemic diseases. The aim of this study was to examine the effect of hypertension and PD on the risk of subsequent systemic disease.
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Gingival landmarks and cutting points for gingival phenotype determination: A clinical and tomographic cross-sectional study J. Periodontol. (IF 4.494) Pub Date : 2022-04-22 Diogo Moreira Rodrigues, Rodrigo Lima Petersen, José Rodrigo de Moraes, Eliane Porto Barboza
This cross-sectional study assessed the role of gingival landmarks (GLs) and cutting points (CPs) for gingival phenotype (GP) determination.
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Does the subepithelial connective tissue graft in conjunction with a coronally advanced flap remain as the gold standard therapy for the treatment of single gingival recession defects? A systematic review and network meta-analysis J. Periodontol. (IF 4.494) Pub Date : 2022-04-22 Leandro Chambrone, João Botelho, Vanessa Machado, Paulo Mascarenhas, José João Mendes, Gustavo Avila-Ortiz
The aim of this systematic review and network meta-analysis (NMA) was to assess the efficacy of a bilaminar root coverage technique consisting of the combination of an autogenous subepithelial connective tissue graft (SCTG) and a coronally advanced flap (CAF) compared with the five most indicated alternative approaches for the treatment of single gingival recession defects (GRD).
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Association of periodontitis, missing teeth, and oral hygiene behaviors with the incidence of hypertension in middle-aged and older adults in Korea: A 10-year follow-up study J. Periodontol. (IF 4.494) Pub Date : 2022-04-21 Su-Yeon Hwang, Hannah Oh, Moo-Yong Rhee, Sangwook Kang, Hae-Young Kim
The relationship between periodontitis and hypertension remains controversial. This study aimed to investigate the association of periodontitis, missing teeth, and oral hygiene behaviors with the incidence of hypertension.
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Interferon activated gene 204 (Ifi204) protects against bone loss in experimental periodontitis J. Periodontol. (IF 4.494) Pub Date : 2022-04-11 Karen V. Swanson, Mustafa Girnary, Tomaz Alves, Jenny PY Ting, Kimon Divaris, Jim Beck, Carolina Maschietto Pucinelli, Raquel Assed Bezerra da Silva, Dilek Uyan, Justin E. Wilson, William T. Seaman, Jennifer Webster-Cyriaque, Nishma Vias, Yizu Jiao, Lloyd Cantley, Arnaud Marlier, Roland R. Arnold, Julie T. Marchesan
Periodontal destruction can be the result of different known and yet-to-be-discovered biological pathways. Recent human genetic association studies have implicated interferon-gamma inducible protein 16 (IFI16) and absent in melanoma 2 (AIM2) with high periodontal interleukin (IL)-1β levels and more destructive disease, but mechanistic evidence is lacking. Here, we sought to experimentally validate
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Periodontitis and cognitive impairment in older adults: The mediating role of mitochondrial dysfunction J. Periodontol. (IF 4.494) Pub Date : 2022-04-01 An Li, Mi Du, Yuntao Chen, Luc A.M. Marks, Anita Visser, Shulan Xu, Geerten-Has E. Tjakkes
Increased attention has been focused on the associations of periodontal disease with the onset and progression of cognitive impairment. Although the associations are likely to be multifactorial, few studies have explored the role of mitochondrial dysfunction in the periodontitis-dementia link.
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Raman microspectroscopy/micro-optical coherence tomography approach for chairside diagnosis of periodontal diseases: A pilot study J. Periodontol. (IF 4.494) Pub Date : 2022-03-31 Arjun Saggu, Gopi Maguluri, John Grimble, Jesung Park, Hatice Hasturk, Nicusor Iftimia, Corneliu Sima
Our objective was to develop and test a combined Raman microspectroscopy (RMS) and micro-optical coherence tomography (μOCT) approach for chairside quantification of gingival collagen, DNA, epithelium, and connective tissue. We hypothesized that a high-resolution RMS/μOCT can characterize healthy and inflamed periodontal tissues for diagnosis and disease activity monitoring.
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Erratum J. Periodontol. (IF 4.494) Pub Date : 2022-03-28
In the article by Lira dos Santos et al.,1 an appendix has been added to the supporting information.
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Association of peptidoglycan recognition protein 1 to post-myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study J. Periodontol. (IF 4.494) Pub Date : 2022-03-28 Nilminie Rathnayake, Anders Gustafsson, Timo Sorsa, Anna Norhammar, Nagihan Bostanci
Peptidoglycan recognition protein 1 (PGLYRP1) is an antimicrobial and proinflammatory innate immunity protein activated during infections. We aimed to investigate whether PGYLRP1 and associated molecules of the immune response in saliva is a cumulative outcome result of both MI and periodontal inflammation.
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Common complement factor H polymorphisms are linked with periodontitis in elderly patients J. Periodontol. (IF 4.494) Pub Date : 2022-03-22 Aino Salminen, Milla Pietiäinen, Susanna Paju, Timo Sorsa, Päivi Mäntylä, Kåre Buhlin, Juha Sinisalo, Pirkko J. Pussinen
In our recent genome-wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP-8) concentration and the release of MMP-8 from neutrophils. As MMP-8 is centrally involved in the pathogenesis of periodontitis, we aimed to evaluate the presence of genetic polymorphisms of S100A8/A9/A12
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Global, regional, and national burden of periodontitis from 1990 to 2019: results from the Global Burden of Disease study 2019 J. Periodontol. (IF 4.494) Pub Date : 2022-03-19 Leng Wu, Sheng-Qi Zhang, Lei Zhao, Zhen-Hu Ren, Chuan-Yu Hu
To evaluate the prevalence and incidence of periodontitis and associated disability-adjusted life years (DALYs) from 1990 to 2019.
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Poor oral health status and adverse COVID-19 outcomes: A preliminary study in hospitalized patients J. Periodontol. (IF 4.494) Pub Date : 2022-03-16 Camila Alves Costa, Ana Carolina Serafim Vilela, Suzane Aparecida Oliveira, Tiago Dias Gomes, Alex Alves Costa Andrade, Cláudio Rodrigues Leles, Nádia Lago Costa
Most of the common risk factors for severe outcomes of coronavirus disease 2019 (COVID-19) are correlated with poor oral health, tooth loss, and periodontitis. This has pointed to a possible relationship between oral and systemic health in COVID-19 patients. Hence, this study aimed to assess the dental and periodontal status of hospitalized COVID-19 patients and their associations with the incidence
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Periodontitis is a potential risk factor for transient ischemic attack and minor ischemic stroke in young adults: A nationwide population-based cohort study J. Periodontol. (IF 4.494) Pub Date : 2022-03-16 Yao-Tung Lee, Chia-Fen Tsai, Yu-Chun Yen, Li-Kai Huang, Shu-Ping Chao, Li-Yu Hu, Cheng-Che Shen, Hsin-Chien Lee
This study aims to determine whether periodontitis is a risk factor for transient ischemic attack (TIA) in young adults.
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Effects of periodontitis and periodontal treatment on systemic inflammatory markers and metabolic profile in obese and non-obese rats J. Periodontol. (IF 4.494) Pub Date : 2022-03-15 Karina Kimiko Yamashina Pereira, Cynthia Mireya Jara, Géssica Luana Antunes, Maximiliano Schünke Gomes, Cassiano Kuchenbecker Rösing, Juliano Cavagni, Alex Nogueira Haas
Little is known about a synergistic effect of periodontitis and obesity on systemic biomarkers and a possible effect periodontal treatment may exert. This study aimed to evaluate the impact of periodontitis and periodontal treatment on systemic inflammation and metabolic profile in obese and non-obese rats.
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Alveolar ridge preservation reduces the need for ancillary bone augmentation in the context of implant therapy J. Periodontol. (IF 4.494) Pub Date : 2022-03-15 Emilio Couso-Queiruga, Cyrus J. Mansouri, Azeez A. Alade, Trishul V. Allareddy, Pablo Galindo-Moreno, Gustavo Avila-Ortiz
There is limited information on the need for bone augmentation in the context of delayed implant placement whether alveolar ridge preservation (ARP) is previously performed or not. The primary aim of this retrospective cohort study was to evaluate the efficacy of ARP therapy after tooth extraction compared with unassisted socket healing (USH) in reducing the need for ancillary bone augmentation before
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Evaluation of the accuracy of soft tissue thickness measurements with three different methodologies: An in vitro study J. Periodontol. (IF 4.494) Pub Date : 2022-03-15 Katherine Ferry, Hawra AlQallaf, Steven Blanchard, Vinicius Dutra, Wei-Shao Lin, Yusuke Hamada
Soft tissue thickness (STT) influences esthetics, peri-implant, and periodontal health. Non-invasive methods of STT evaluation include cone-beam computed tomography (CBCT) with Digital Imaging and Communications in Medicine (DICOM) files and registration of DICOM files with an intraoral scan or Standard Tessellation Language (STL) files. This study compares three methodologies: bone sounding, DICOM
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The spatial and temporal trends of severe periodontitis burden in Asia, 1990–2019: A population-based epidemiological study J. Periodontol. (IF 4.494) Pub Date : 2022-03-15 Li-Sha Luo, Hang-Hang Luan, Jun-Feng Jiang, Lan Wu, Cheng Li, Wei-Dong Leng, Xian-Tao Zeng
To investigate the long-term and spatial patterns of incidence, prevalence, and disability-adjusted life year (DALY) rates of severe periodontitis in Asia from 1990 to 2019, and to estimate the associations between disease burden and socioeconomic development using the Socio-Demographic Index (SDI).