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Effects of intermittent fasting on periodontal inflammation and subgingival microbiota J. Periodontol. (IF 4.3) Pub Date : 2024-04-24 Ronaldo Lira‐Junior, Micheál Mac Aogáin, Eva Crncalo, Neda Rajamand Ekberg, Sanjay H. Chotirmall, Sven Pettersson, Anders Gustafsson, Kerstin Brismar, Nagihan Bostanci
BackgroundStudies on the impact of intermittent fasting on periodontal health are still scarce. Thus, this study evaluated the effects of long‐term intermittent fasting on periodontal health and the subgingival microbiota.MethodsThis pilot study was part of a nonrandomized controlled trial. Overweight/obese participants (n = 14) entered an intermittent fasting program, specifically the 5:2 diet, in
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Patient awareness of the association between periodontal and systemic diseases in an academic setting J. Periodontol. (IF 4.3) Pub Date : 2024-04-12 William Carter, Tamanna Tiwari, Satheesh Elangovan, Lonnie Johnson, Karo Parsegian, Sangeetha Chandrasekaran
BackgroundPeriodontal diseases (PD) have been increasingly associated with several systemic conditions such as cardiovascular disease (CVD), diabetes mellitus (DM), rheumatoid arthritis (RA), and Alzheimer's disease (AD). This study aimed to gain insight into patients’ awareness of the association between PD and systemic diseases.MethodsA survey was developed to analyze patient awareness of the association
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Association of periodontitis with gastrointestinal tract disorders: A bidirectional Mendelian randomization study J. Periodontol. (IF 4.3) Pub Date : 2024-04-02 Yuqiang Wang, Jiakang Zhu, Ying Tang, Cui Huang
BackgroundThe bidirectional link of periodontitis (PD) and gastrointestinal tract (GIT) disorders has been investigated in previous epidemiological studies; however, the conclusions still remain controversial. The aim of this study was to comprehensively explore the bidirectional causal effect between PD and various GIT diseases.MethodsBased on summary‐level data of genome‐wide association studies
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Evaluation of acceptance and preference of topical lidocaine application versus articaine injection anesthesia after nonsurgical periodontal treatment: A randomized clinical trial J. Periodontol. (IF 4.3) Pub Date : 2024-04-02 Christof Dörfer, Kathrin Chmiela, Nicole B. Arweiler, Gregor J. Petersilka, Henrik Dommisch, Ralph Heckel, Maren Kahl, Denica Kuzmanova, Peter Purucker, Claudia Springer
BackgroundTo compare acceptance and preference of topical lidocaine gel anesthesia with articaine injection anesthesia in patients with moderate periodontitis undergoing scaling and root debridement.MethodsNinety‐one patients completed this randomized multicenter split‐mouth controlled study and underwent two separate periodontal treatment sessions on different days, one with a topical intrapocket
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MyD88 exacerbates inflammation‐induced bone loss by modulating dynamic equilibrium between Th17/Treg cells and subgingival microbiota dysbiosis J. Periodontol. (IF 4.3) Pub Date : 2024-03-25 Po‐Yan Hsiao, Ren‐Yeong Huang, Lin‐Wei Huang, Ching‐Liang Chu, Thomas Van Dyke, Lian‐Ping Mau, Chia‐Dan Cheng, Cheng‐En Sung, Pei‐Wei Weng, Yu‐Chiao Wu, Yi‐Shing Shieh, Wan‐Chien Cheng
BackgroundThis study aimed to investigate the contribution of myeloid differentiation primary‐response gene 88 (MyD88) on the differentiation of T helper type 17 (Th17) and regulatory T (Treg) cells and the emerging subgingival microbiota dysbiosis in Porphyromonas gingivalis‐induced experimental periodontitis.MethodsAlveolar bone loss, infiltrated inflammatory cells, immunostained cells for tartrate‐resistant
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Efficacy of photodynamic therapy as an adjunct to scaling and root planing on clinical parameters and microbial composition in subgingival plaque of periodontitis patients: A split‐mouth randomized clinical trial J. Periodontol. (IF 4.3) Pub Date : 2024-03-19 Min Nie, Peien Huang, Peiyao Peng, Daonan Shen, Lei Zhao, Duan Jiang, Yuqin Shen, Lai Wei, Paul W. Bible, Jingmei Yang, Jun Wang, Yafei Wu
BackgroundThe aim of this study was to assess the efficacy of photodynamic therapy (PDT) as an adjunct to scaling and root planing (SRP) on clinical parameters and microbial composition in subgingival plaque of periodontitis patients.MethodsSeventeen patients were included in this split‐mouth randomized clinical trial. Sites with probing pocket depth (PPD) ≥5 mm in combination with bleeding on probing
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Leukemia inhibitory factor protects against experimental periodontitis through immuno‐modulations of both macrophages and periodontal ligament fibroblasts J. Periodontol. (IF 4.3) Pub Date : 2024-03-16 Yanjing Ou, Le Fan, Xiaoqi Wang, Haibin Xia, Mengwen Cheng, Jing Huang, Youde Liang, Yining Wang, Yi Zhou
BackgroundTo explore the role of leukemia inhibitory factor (LIF) in periodontitis via in vivo and in vitro experiments.MethodsThe second upper molar of LIF knockout mice and their wild‐type littermates were ligated for 8 days. Micro‐computed tomography (micro‐CT), histological analysis, and quantitative real‐time polymerase chain reaction (qRT‐PCR) were performed. The expression levels of proinflammatory
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Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals J. Periodontol. (IF 4.3) Pub Date : 2024-03-13 Sungeun Stephanie Koo, Jussara G. Fernandes, Lu Li, Hong Huang, Ikramuddin Aukhil, Peter Harrison, Patricia I. Diaz, Luciana M. Shaddox
BackgroundThe aim of the present study was to evaluate the subgingival microbiome in patients with grade C molar‐incisor pattern periodontitis (C‐MIP) affecting the primary or permanent dentitions.MethodsDNA was isolated from subgingival biofilm samples from diseased and healthy sites from 45 C‐MIP patients and subjected to phylogenetic microarray analysis. C‐MIP sites were compared between children
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Evaluation of the effect of Er,Cr:YSGG laser application on peri‐implant crevicular fluid receptor activator of nuclear factor‐kappa B ligand and osteoprotegerin levels in the non‐surgical treatment of peri‐implantitis: A randomized clinical trial J. Periodontol. (IF 4.3) Pub Date : 2024-02-20 Nazli Zeynep Alpaslan, Dicle Altindal, Damla Akbal, Ahmet Cemil Talmac, Serap Keskin Tunc, Abdullah Seckin Ertugrul
BackgroundThis study aimed to investigate the effect of erbium, chromium doped:yttrium,scandium,gallium,garnet (Er,Cr:YSGG) laser application combined with non‐surgical mechanical debridement (MD) on clinical parameters and peri‐implant crevicular fluid receptor activator of nuclear factor‐kappa B ligand (RANKL) and osteoprotegerin (OPG) levels in the treatment of peri‐implantitis.MethodsA total of
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Artificial intelligence in dental education: ChatGPT's performance on the periodontic in-service examination J. Periodontol. (IF 4.3) Pub Date : 2024-01-10 Arman Danesh, Hirad Pazouki, Farzad Danesh, Arsalan Danesh, Saynur Vardar-Sengul
ChatGPT's (Chat Generative Pre-Trained Transformer) remarkable capacity to generate human-like output makes it an appealing learning tool for healthcare students worldwide. Nevertheless, the chatbot's responses may be subject to inaccuracies, putting forth an intense risk of misinformation. ChatGPT's capabilities should be examined in every corner of healthcare education, including dentistry and its
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Validity of individual self-report oral health measures in assessing periodontitis for causal research applications J. Periodontol. (IF 4.3) Pub Date : 2024-01-10 Julia C. Bond, Sharon M. Casey, Robert McDonough, Suzanne G. McLone, Mabeline Velez, Brenda Heaton
Self-reported measures of periodontitis developed for use in population surveillance are increasingly used in causal research. Numerous studies evaluate the validity of these measures against clinical parameters of periodontitis, yet few include validation parameters outside of multivariable models. Individual item validity is necessary to adequately inform use of these measures in causal research
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Periodontists and stem cell-based therapy for alveolar bone regeneration: A national survey J. Periodontol. (IF 4.3) Pub Date : 2024-01-09 Darnell Kaigler, Jonathan Misch, Abdusalam Alrmali, Marita R. Inglehart
Stem cell-based therapy for bone regeneration has received attention in medical settings but has not yet been used in clinical practice for treating alveolar bone defects. The objectives of this study were to explore whether periodontists had heard about this approach, and if so how, how interested they were to learn about it, which attitudes and behavioral intentions they had related to using stem
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Risk indicators for gingival recession in the esthetic zone: A cross-sectional clinical, tomographic, and ultrasonographic study J. Periodontol. (IF 4.3) Pub Date : 2024-01-09 Kathleen Chloe Mascardo, Justin Tomack, Chia-Yu Chen, Leonardo Mancini, David M. Kim, Bernard Friedland, Shayan Barootchi, Lorenzo Tavelli
To evaluate the risk indicators associated with midfacial gingival recessions (GR) in the natural dentition esthetic regions.
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Impact of dietary inflammatory index on gingival health J. Periodontol. (IF 4.3) Pub Date : 2023-12-28 Roberta Andrade Reis, Camila Schmidt Stolf, Helena Alves de Carvalho Sampaio, Bruna Yhang da Costa Silva, Tuğçe Özlü, Emre Batuhan Kenger, Manuela Maria Vianal Miguel, Mauro Pedrine Santamaria, Mabelle de Freitas Monteiro, Marcio Zaffalon Casati, Renato Corrêa Viana Casarin
Periodontal disease is a biofilm-dependent chronic inflammatory condition triggered by a host response. Several factors impact systemic inflammation and could lead to changes in disease pathogenesis. Recently, studies have assessed the influence of nutritional patterns on the development of periodontitis. In the present cross-sectional study, we evaluated the dietary inflammatory profile on periodontal
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Association of active oxygen-releasing gel and photodynamic therapy in the treatment of residual periodontal pockets in type 2 diabetic patients: A randomized controlled clinical study J. Periodontol. (IF 4.3) Pub Date : 2023-12-19 Marina M. Cláudio, Valdir G. Garcia, Rubens M. Freitas, João Victor S. Rodrigues, Mark Wainwright, Renato C. V. Casarin, Cristiane Duque, Leticia H. Theodoro
The aim of this study was to evaluate the effect of active oxygen-releasing gel as an adjuvant, with and without antimicrobial photodynamic therapy (aPDT), in the treatment of residual pockets in periodontal patients with type 2 diabetes mellitus (DM2).
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Influence of residual pockets on periodontal tooth loss: a retrospective analysis J. Periodontol. (IF 4.3) Pub Date : 2023-12-19 Muhammad H. A. Saleh, Debora R. Dias, Obada Mandil, Ricardo P. de Oliveira, Abdusalam Alrmali, Maurício G. Araújo, Hom-Lay Wang, Zoltan Barath, Istvan A. Urban
Individuals enrolled in supportive periodontal therapy (SPT) can still present with tooth loss due to periodontitis (TLP). There is limited evidence on the influence of residual pockets (RPc) and a defined “threshold” at which a patient's profile is set to be at high risk for TLP in the literature. Therefore, this study aimed to assess the influence of RPc on TLP and determine the prognostic performance
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Human gingival fibroblasts are a source of B cell-activating factor during periodontal inflammation J. Periodontol. (IF 4.3) Pub Date : 2023-12-13 Ahed Dyab, Ava Emnegard, Magnus Wänman, Filippa Sjöström, Elin Kindstedt
Host-modulating therapy is a possible treatment for individuals that respond poorly to conventional periodontal therapy. B cells, abundant in periodontitis lesions, require the cytokines B cell-activating factor (BAFF) and A proliferation-inducing ligand (APRIL) for survival and maturation. Although mRNA levels of BAFF and APRIL are increased in tissue from periodontitis lesions, it is unknown if periodontal
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Harvest graft substitute for soft tissue volume augmentation around existing implants: A randomized, controlled and blinded multicenter trial J. Periodontol. (IF 4.3) Pub Date : 2023-12-09 Donald S. Clem, Pamela K. McClain, Michael K. McGuire, Chris R. Richardson, Greg A. Santarelli, Rachel A. Schallhorn, E. Todd Scheyer, John C. Gunsolley, Thiago Morelli
Using a single-blind, randomized, controlled, multicenter, practice-based clinical trial, a volume-stable collagen matrix (VCMX) was compared with connective tissue graft (CTG) for soft tissue augmentation around existing dental implants.
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Melatonin supports nonsurgical periodontal treatment in patients with Type 2 diabetes mellitus and periodontitis: A randomized clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-12-06 Yagmur Sarac Gul, Oguz Kose, Ahmet Altin, Hatice Yemenoglu, Hatice Arslan, Kerimali Akyildiz, Adnan Yilmaz
Diabetes mellitus (DM)-associated hyperinflammatory host response significantly provokes periodontal tissue destruction. In this context, the support of nonsurgical periodontal therapy in diabetics with host modulation agents is a current field of study. This clinical study aims to investigate the clinical efficacy of melatonin supplementation and discuss its possible biological mechanisms in nonsurgical
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Resolution of peri-implant mucositis following standard treatment: A prospective split-mouth study J. Periodontol. (IF 4.3) Pub Date : 2023-12-02 Mia Rakic, Zoran Tatic, Sandro Radovanovic, Aleksandra Petkovic-Curcin, Danilo Vojvodic, Alberto Monje
Peri-implant mucositis (PIM) is a pathological precursor of peri-implantitis, but its pattern of conversion to peri-implantitis is unclear and complicated to diagnose clinically, while none of the available protocols yield complete disease resolution. The aim of this study was the evaluation of PIM responsiveness to standard anti-infective mechanical treatment (AIMT) at clinical and biomarker levels
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Assessment of bone defect morphology for the adjunctive use of bone grafting combined with enamel matrix derivative: A 3-year cohort study J. Periodontol. (IF 4.3) Pub Date : 2023-11-29 Takanori Matsuura, Risako Mikami, Koji Mizutani, Hidehiro Shioyama, Norio Aoyama, Tomonari Suda, Yukako Kusunoki, Kohei Takeda, Yuichi Izumi, Jun Aida, Akira Aoki, Takanori Iwata
There have been limited studies with statistically sufficient sample sizes for assessment of suitable bone defect morphology for combination therapy with enamel matrix derivative (EMD) and bone grafting. The aim of this study was to investigate the appropriate feature of intrabony defects, such as bone defect angle (DA) and the containment by bony wall, for yielding the additional benefit of bone grafting
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Enhanced periodontal tissue healing via vascular endothelial growth factor expression following low-level erbium-doped: yttrium, aluminum, and garnet laser irradiation: In vitro and in vivo studies J. Periodontol. (IF 4.3) Pub Date : 2023-11-27 Shu Takemura, Koji Mizutani, Risako Mikami, Keita Nakagawa, Masahiro Hakariya, Eri Sakaniwa, Natsumi Saito, Hiromi Kominato, Daisuke Kido, Kohei Takeda, Akira Aoki, Takanori Iwata
This study aimed to investigate the effects of low-level erbium-doped: yttrium, aluminum, and garnet (Er:YAG) laser irradiation on periodontal tissue healing and regeneration through angiogenesis in vivo and in vitro studies.
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Mediating role of systemic inflammation in the association between heavy metals exposure and periodontitis risk J. Periodontol. (IF 4.3) Pub Date : 2023-11-21 Mi Du, Ke Deng, Qingqing Cai, Shixian Hu, Yuntao Chen, Shulan Xu, Geerten-Has E. Tjakkes, Shaohua Ge, Minghua Ge, An Li
This study evaluated the mediating role of systemic inflammation in the association between exposure to heavy metals and periodontitis in a nationwide sample of adults.
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Association of environmental polycyclic aromatic hydrocarbons exposure with periodontitis in NHANES 2009–2014: A mixtures approach J. Periodontol. (IF 4.3) Pub Date : 2023-11-21 Jinqiu Sun, Feifei Guo, Lin Wang, Fulei Han, Jia Yang, Shengli Gao
Polycyclic aromatic hydrocarbons (PAHs) can invade and cause harm to the human body through various pathways, but there is currently little research on the relationship between mixed-PAHs exposure and periodontitis. The purpose of this study was to examine the effects of mixed-urinary PAHs exposure on periodontitis in adults in the United States.
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Association between sequelae of COVID-19 with periodontal disease and obesity: A cross-sectional study J. Periodontol. (IF 4.3) Pub Date : 2023-11-21 Maísa Casarin, Francisco Hecktheuer Silva, Ana Flávia Leite Pontes, Betina Dutra Lima, Flavia Q. Pirih, Francisco Wilker Mustafa Gomes Muniz
To assess the sequelae of coronavirus disease 2019 (COVID-19) and associated factors, such as obesity and periodontitis in adults.
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Possible role of annexin A1/FPR2 pathway in COX2/NLRP3 inflammasome regulation in alveolar bone cells of estrogen-deficient female rats with diabetes mellitus J. Periodontol. (IF 4.3) Pub Date : 2023-11-21 Gisela Rodrigues Da Silva Sasso, Paulo Sérgio Cerri, Estela Sasso-Cerri, Manuel Jesus Simões, Cristiane Damas Gil, Rinaldo Florencio-Silva
Annexin A1 (ANXA1) and the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome play important roles in bone remodeling. However, expression profiles of these factors in bone cells under diabetes mellitus (DM) and estrogen-deficient conditions are poorly understood. This study investigated the immunoexpression of ANXA1 and its formyl peptide receptor 2 (FPR2), as well as
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Clinical and radiographic evaluation of the use of PRF, CGF, and autogenous bone in the treatment of periodontal intrabony defects: Treatment of periodontal defect by using autologous products J. Periodontol. (IF 4.3) Pub Date : 2023-11-20 Basem Alshujaa, Ahmet Cemil Talmac, Dicle Altindal, Anas Alsafadi, Abdullah Seckin Ertugrul
The purpose of this randomized clinical study was to clinically evaluate and compare the efficiencies of platelet-rich fibrin (PRF), concentrated growth factor (CGF) and autogenous bone graft (ABG) in the treatment of intrabony pockets and to assess the alveolar bone gain (AB gain) radiographically (panoramic and CBCT images).
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Extracellular adenosine triphosphate regulates inflammatory responses of periodontal ligament cells J. Periodontol. (IF 4.3) Pub Date : 2023-11-06 Maythwe Kyawsoewin, Jeeranan Manokawinchoke, Chutimon Termkwanchareon, Hiroshi Egusa, Thanaphum Osathanon, Phoonsuk Limraksasin
Various stimuli, that is, mechanical stresses or inflammation, induce the release of adenosine triphosphate (ATP) by human periodontal ligament cells (HPDLCs). Extracellular adenosine triphosphate (eATP) affects HPDLCs’ functions such as immunosuppressive action and inflammatory responses. Lipopolysaccharide (LPS) is the key factor involved in periodontal inflammation. However, the possible correlation
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Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats J. Periodontol. (IF 4.3) Pub Date : 2023-11-03 Wei Qiu, Qian Sun, Na Li, Zehao Chen, Hongle Wu, Zhao Chen, Xiaolan Guo, Fuchun Fang
Osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) is an essential event in alveolar bone regeneration. Oxidative stress may be the main inhibiting factor of hPDLSC osteogenesis. Superoxide dismutase 2 (SOD2) is a key antioxidant enzyme, but its effect on hPDLSC osteogenic differentiation is unclear.
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Suppression of subgingival bacteria by antimicrobial photodynamic therapy using transgingival irradiation: A randomized clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-11-01 Jun-ichiro Hayashi, Kohta Ono, Yuki Iwamura, Yasuyuki Sasaki, Tasuku Ohno, Ryoma Goto, Eisaku Nishida, Genta Yamamoto, Takeshi Kikuchi, Naoya Higuchi, Akio Mitani, Mitsuo Fukuda
Antimicrobial photodynamic therapy (aPDT) is an effective method for eradicating bacteria in periodontal therapy. Standard aPDT requires the insertion of a laser tip into a periodontal pocket, in which the direction of irradiation is limited. Therefore, we devised an aPDT method that uses a transgingival near-infrared wavelength and indocyanine green-encapsulated and chitosan-coated nanoparticles as
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Aggressive periodontitis in southwestern American Indian adolescents J. Periodontol. (IF 4.3) Pub Date : 2023-11-01 Thomas E. Rams, Adolfo Contreras, Jørgen Slots
This study determined the prevalence of aggressive (molar-incisor pattern) (Ag/MI) periodontitis and assessed the associated subgingival bacterial-herpesvirus microbiota in Pueblo Indian adolescents in the southwestern United States.
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Effects of a stabilized stannous fluoride dentifrice on clinical, immunomodulatory, and microbial outcomes in a human experimental gingivitis model J. Periodontol. (IF 4.3) Pub Date : 2023-10-27 Noah Fine, Abdelahhad Barbour, Kamini Kaura, Kristopher A. Kerns, Dandan Chen, Harsh M. Trivedi, Juliana Gomez, Amarpreet Sabharwal, Jeffrey S. McLean, Richard P. Darveau, Michael Glogauer
Stannous fluoride dentifrice is well established for its beneficial clinical effects. In this study, we evaluated the effects of stannous fluoride on inflammation and oral microbiome.
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Prevalence, risk indicators, and clinical characteristics of peri-implant mucositis and peri-implantitis for an internal conical connection implant system: A multicenter cross-sectional study J. Periodontol. (IF 4.3) Pub Date : 2023-10-17 Karin Apaza-Bedoya, Maria Elisa Galarraga-Vinueza, Bruna Barbosa Correa, Frank Schwarz, Marco Aurélio Bianchini, Cesar Augusto Magalhães Benfatti
Peri-implant disease prevalence is associated with a multifactorial etiology and distinct clinical characteristics of inflammation.
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Comparative evaluation of semaphorin-4D, peptidylarginine deiminase-2, and matrix metalloproteinase-8 levels of gingival crevicular fluid in periodontally healthy and Stage III periodontitis smoker and non-smoker patients before and after non-surgical periodontal therapy J. Periodontol. (IF 4.3) Pub Date : 2023-10-17 Aishwarya S. Ikhar, Rajashri A. Kolte, Abhay P. Kolte, Prachi R. Rathi, Dhanashree G. Ghoderao, Rahul N. Dahake
This study was designed to assess the influence of non-surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) levels of semaphorin-4D (SEMA-4D), peptidylarginine deiminase-2 (PAD-2), and matrix metalloproteinase-8 (MMP-8) levels in periodontally healthy, Stage III periodontitis non-smoker and smoker patients.
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A comparison of Er,Cr:YSGG laser to minimally invasive surgical technique in the treatment of intrabony defects: Twelve-month results of a multicenter, randomized, controlled study J. Periodontol. (IF 4.3) Pub Date : 2023-10-17 Donald Clem, Rick Heard, Michael McGuire, E. Todd Scheyer, Chris Richardson, Gregory Toback, John C. Gunsolley, Nico Geurs
The purpose of this publication is to report on the 12-month clinical and radiographic results comparing the surgical use of the Er,Cr:YSGG laser (ERL) and minimally invasive surgical technique (MIST) for the treatment of intrabony defects in subjects with generalized periodontitis stage III, grade B.
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Relationship between C-reactive protein level and periodontitis and systemic diseases J. Periodontol. (IF 4.3) Pub Date : 2023-10-16 Jung-Hwa Lee, So-Jung Mun
Periodontitis affects systemic disease risk, although the relationship thereof in the context of different C-reactive protein (CRP) levels is not clear. This study investigated the association of periodontitis with systemic diseases according to high-sensitivity CRP (hs-CRP) level and sought to identify the risk of systemic diseases in patients with periodontitis.
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The associations of coffee consumption, coffee types, and caffeine metabolites with periodontitis: Results from NHANES 2009–2014 J. Periodontol. (IF 4.3) Pub Date : 2023-10-10 Qiansi Chen, Ruiyang Ge, Yuxuan Wu, Yuying Wu, Han Yang, Yiming Yu, Qingrong Deng, Yu Qiu, Baochang He, Fuhua Yan, Yanfen Li, Fa Chen
Coffee is one of the world's most popular beverages and is the main dietary source of caffeine for most people. The various molecular effects of caffeine suggest that it may enhance bone loss. The purpose of the present study was to investigate the relationship of coffee, coffee types, and caffeine metabolites with periodontitis.
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Association between antihyperlipidemic agents and the risk of chronic periodontitis in patients with hyperlipidemia: A population-based retrospective cohort study in Taiwan J. Periodontol. (IF 4.3) Pub Date : 2023-10-04 An-Yi Wang, Guan-Ling Lin, Joseph Jordan Keller, Li-Hsuan Wang
The lipid-lowering and anti-inflammatory effects of statins and fibrates may ameliorate periodontitis. Patients with hyperlipidemia tend to have a worse periodontal status. This study assessed the association between the use of statins/fibrates and the incidence of chronic periodontitis in patients with hyperlipidemia in Taiwan.
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The effect of a multicomponent oral care regimen on gingival inflammation: A randomized controlled clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-10-04 Guilherme C. L. S. do Amaral, Mohamed A. Hassan, Luciana Saraiva, Laís Y. S. Nakao, Marinella Holzhausen, Zilson M. Malheiros, Bernal Stewart, Giuseppe A. Romito, Cristina C. Villar
Oral care regimens can be explored to improve oral health in patients with gingivitis. This study aimed to evaluate the efficacy of a multicomponent oral care regimen with a dual zinc plus arginine (DZA) toothpaste and cetylpyridinium chloride with zinc lactate (CPC + Zn) mouthwash in reducing gingival bleeding in patients with gingivitis.
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Association between missing teeth number and all-cause and cardiovascular mortality: NHANES 1999–2004 and 2009–2014 J. Periodontol. (IF 4.3) Pub Date : 2023-10-04 Ruming Shen, Shuaijie Chen, Jiayi Shen, Lingchun Lv, Tiemin Wei
The association between tooth loss and all-cause and cardiovascular mortality requires further investigation.
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Comparative transcriptome analysis of periodontitis and peri-implantitis in human subjects J. Periodontol. (IF 4.3) Pub Date : 2023-10-03 Jung-Min Oh, Yeongjoo Kim, Hyojae Son, Yun Hak Kim, Hyun-Joo Kim
Peri-implantitis is similar to periodontitis, but there are some differences. For the effective control of peri-implantitis, it is necessary to clarify its similarities and differences with periodontitis in terms of gene expression.
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Local application of gingiva-derived mesenchymal stem cells on experimental periodontitis in rats J. Periodontol. (IF 4.3) Pub Date : 2023-10-03 Yunus Emre Balaban, Sema Akbaba, Serife Buket Bozkurt, Arda Buyuksungur, E. Ece Akgun, Zeynep Burcin Gonen, Hasan Salkin, Aysen Tezcaner, Sema S. Hakki
Stem cell-based approaches in regenerative periodontal therapy have been used in different experimental models. In this study, the effect of local application of gingival mesenchymal stem cells (GMSC) in fibroin/chitosan oligosaccharide lactate hydrogel (F/COS) on periodontal regeneration was evaluated using experimental periodontitis model in rats.
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An in vitro dynamic bioreactor model for evaluating antimicrobial effectiveness on periodontal polymicrobial biofilms: a proof-of-concept study J. Periodontol. (IF 4.3) Pub Date : 2023-09-19 Srinivas Sulugodu Ramachandra, Fekade Bruck Sime, Saiyuri Naicker, Pingping Han, Ryan SB Lee, Steven C Wallis, Jason A Roberts, Sašo Ivanovski
The aim of this study was to investigate an in vitro dynamic bioreactor model by evaluating the antimicrobial effect of clinically relevant amoxicillin doses on polymicrobial microcosm biofilms derived from subgingival plaque.
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J-shaped association between systemic immune-inflammation index and periodontitis: Results from NHANES 2009–2014 J. Periodontol. (IF 4.3) Pub Date : 2023-09-15 Ruoyan Cao, Chen Li, Fengxue Geng, Yaping Pan
To examine the relationship between the systemic immune-inflammation index (SII) and periodontitis and to investigate possible effect modifiers.
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Impact of surface characteristics on the peri-implant microbiome in health and disease J. Periodontol. (IF 4.3) Pub Date : 2023-09-04 Khaled Sinjab, Shriya Sawant, Alice Ou, J. Christopher Fenno, Hom-Lay Wang, Purnima Kumar
Because little is known about the impact of implant surface modifications on the peri-implant microbiome, we aimed to examine peri-implant communities in various surface types in order to better understand the impact of these surfaces on the development of peri-implantitis (PI).
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Alveolar mucosal cell spheroids promote extraction socket healing and osseous defect regeneration J. Periodontol. (IF 4.3) Pub Date : 2023-08-02 Che-Chang Tu, Zhao-Cheng Zheng, Nai-Chen Cheng, Jiashing Yu, Wei-Chiu Tai, Yi-Xuan Pan, Po-Chun Chang
Alveolar mucosa could be a promising source of mesenchymal stem cells (MSCs) for regeneration therapeutics because it exhibits faster healing potential and can be easily collected with minimal periodontal disturbance. This study aimed to evaluate the potential of alveolar mucosal cell (AMC) spheroids for promoting extraction socket healing and calvarial osseous defect regeneration.
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Influences of standardized clinical probing on peri-implant soft tissue seal in a situation of peri-implant mucositis: A histomorphometric study in dogs J. Periodontol. (IF 4.3) Pub Date : 2023-07-29 Rong Cai, Yi Liu, Xinge Wang, Hongbo Wei, Jin Wang, Yanze Cao, Jiaqi Lei, Dehua Li
Clinical probing is commonly recommended to evaluate peri-implant conditions. In a situation of peri-implant mucositis or peri-implantitis, the peri-implant seal healing from the disruption of soft tissue caused by probing has not yet been studied. This study aimed to investigate soft tissue healing after standardized clinical probing around osseointegrated implants with peri-implant mucositis in a
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Temporal and spatial effects on C-reactive protein's regulation of inducible nitric oxide synthase production in periodontal disease J. Periodontol. (IF 4.3) Pub Date : 2023-07-29 Lingjie Li, Lurong Jia, Siyu Hou, Tingwei Zhang, Mengjiao Zhou, Tao Chen, Jinlin Song
Inducible nitric oxide synthase (iNOS) is associated with inflammation and osteoclastic differentiation in periodontal disease. This study was conducted to compare the time-dependent variation in iNOS production between the gingiva and other periodontal tissues and to explore the potential association with C-reactive protein (CRP) in early periodontal disease.
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Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet-rich fibrin over platelet-rich fibrin alone in treatment of Grade II furcation defects: A randomized controlled double-blind clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-07-29 Srushti K. Dhande, Surekha R. Rathod, Abhay P. Kolte, Vrushali N. Lathiya, Palak A. Kasliwal
The present study aims to evaluate and compare the effects of 1% melatonin gel plus platelet-rich fibrin (PRF) and PRF alone in treatment of furcation defects, clinically and radiographically using cone-beam computed tomography.
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Sex differences in the association between dual-energy x-ray absorptiometry-measured body composition and periodontitis J. Periodontol. (IF 4.3) Pub Date : 2023-07-28 Peijun Zhu, An Li, Qingqing Cai, Yuntao Chen, Yang Liu, Harriët Jager-Wittenaar, Geerten-Has E. Tjakkes, Shulan Xu
A positive association between obesity based on body mass index (BMI) and periodontitis has been reported. Fat tissue-related systemic inflammation acts as the link to periodontal comorbidities of obesity. However, the BMI is unable to distinguish fat and fat-free tissues. More precise measures are required to evaluate body composition, including fat and fat-free tissues. This study aimed to determine
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Activation of periodontal ligament cell cytodifferentiation by juxtacrine signaling from cementoblasts J. Periodontol. (IF 4.3) Pub Date : 2023-07-26 Keigo Sawada, Junpei Shimomura, Masahide Takedachi, Mari Murata, Chiaki Morimoto, Kohsuke Kawasaki, Kazuma Kawakami, Tomoaki Iwayama, Shinya Murakami
New cementum forms from existing cementum during periodontal tissue regeneration, indicating that cementoblasts may interact with progenitor cells in the periodontal ligament to enhance cementogenesis. However, the molecular mechanisms of this process are currently unknown. This study aims to clarify the role of cell-cell interactions between cementoblasts and periodontal ligament cells in differentiation
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Evidence linking the association of periodontal viruses and pentraxins in periodontitis patients with coronary artery disease J. Periodontol. (IF 4.3) Pub Date : 2023-07-22 Paavai Ilango, Jaideep Mahendra, Little Mahendra, Sanjay M. Cherian, Vasugi Suresh, Arulpari Mahalingam, V. Vinoth Khanna, Ayswarya V Vummidi, Abirami Thanigaimalai, Pavithra H. Dave
Although there is ample evidence in the literature supporting a significant positive association between key periodontal pathogens and established inflammatory markers of periodontitis and coronary artery disease (CAD), their exact role remain unclear. Especially, the role of viruses in the etiology and specific biomarkers have not been validated. Thus, the current study aims to evaluate the role of
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Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes J. Periodontol. (IF 4.3) Pub Date : 2023-07-21 Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, Sathiyapriya Viswanathan, Renuka Devy Thirumalai Nathan
Aberrant deoxyribonucleic acid (DNA) contributes to inflammasome orchestrated progression of chronic inflammatory diseases like diabetes and periodontitis. The purpose of the present study was to estimate salivary levels of DNA sensing inflammasomes, absent in melanoma 2 (AIM2), interferon γ inducible protein (IFI16), and cytokine interleukin 18 (IL18) in individuals with periodontitis, diabetes, and
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Multiplicative effect of stress and poor sleep quality on periodontitis: A university-based cross-sectional study J. Periodontol. (IF 4.3) Pub Date : 2023-07-21 Crystal Marruganti, Carlo Gaeta, Mario Romandini, Edoardo Ferrari Cagidiaco, Stefano Parrini, Nicola Discepoli, Simone Grandini
The aim of this study was to evaluate the association of perceived stress and poor sleep quality with periodontitis in a university-based cohort of individuals.
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Bioactive glass and arginine dentifrices reduce root sensitivity during daily activities following non-surgical periodontal therapy: A randomized controlled trial J. Periodontol. (IF 4.3) Pub Date : 2023-07-20 Chantrakorn Champaiboon, Napassorn Ongphichetmetha, Attawood Lertpimonchai
Evidence on the efficacy of calcium sodium phosphosilicate (CSPS) and arginine dentifrices on reducing root sensitivity (RS) following non-surgical periodontal therapy (NSPT) is limited. The aim of this study was to compare the efficacy of these dentifrices in reducing RS during daily activities in patients undergoing NSPT.
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Association between periodontitis and mortality of patients with cardiovascular diseases: A cohort study based on NHANES J. Periodontol. (IF 4.3) Pub Date : 2023-07-19 Fangman Chen, Yansong Song, Weiqi Li, Hao Xu, Hongxia Dan, Qianming Chen
The association between periodontitis and cardiovascular disease (CVD) has been widely explored, but little is known about the effect of periodontitis on the mortality of CVD patients. This study aims to clarify the effect of periodontitis on all-cause and cause-specific mortality of CVD patients.
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Patients with inflammatory bowel disease have more oral health problems and higher costs of professional dental care than healthy controls: The Periodontitis Prevalence in ulcerative Colitis and Crohn disease (PPCC) case-control study J. Periodontol. (IF 4.3) Pub Date : 2023-07-19 Kristina Bertl, Johan Burisch, Nikolaos Pandis, Björn Klinge, Andreas Stavropoulos
To describe the frequency and impact of oral lesions and professional dental care costs in patients with inflammatory bowel disease (IBD) (i.e., Crohn disease [CD] or ulcerative colitis [UC]) compared to matched controls).