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Melatonin supports nonsurgical periodontal treatment in patients with Type 2 diabetes mellitus and periodontitis: A randomized clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-12-06 Yagmur Sarac Gul, Oguz Kose, Ahmet Altin, Hatice Yemenoglu, Hatice Arslan, Kerimali Akyildiz, Adnan Yilmaz
Diabetes mellitus (DM)-associated hyperinflammatory host response significantly provokes periodontal tissue destruction. In this context, the support of nonsurgical periodontal therapy in diabetics with host modulation agents is a current field of study. This clinical study aims to investigate the clinical efficacy of melatonin supplementation and discuss its possible biological mechanisms in nonsurgical
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Resolution of peri-implant mucositis following standard treatment: A prospective split-mouth study J. Periodontol. (IF 4.3) Pub Date : 2023-12-02 Mia Rakic, Zoran Tatic, Sandro Radovanovic, Aleksandra Petkovic-Curcin, Danilo Vojvodic, Alberto Monje
Peri-implant mucositis (PIM) is a pathological precursor of peri-implantitis, but its pattern of conversion to peri-implantitis is unclear and complicated to diagnose clinically, while none of the available protocols yield complete disease resolution. The aim of this study was the evaluation of PIM responsiveness to standard anti-infective mechanical treatment (AIMT) at clinical and biomarker levels
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Assessment of bone defect morphology for the adjunctive use of bone grafting combined with enamel matrix derivative: A 3-year cohort study J. Periodontol. (IF 4.3) Pub Date : 2023-11-29 Takanori Matsuura, Risako Mikami, Koji Mizutani, Hidehiro Shioyama, Norio Aoyama, Tomonari Suda, Yukako Kusunoki, Kohei Takeda, Yuichi Izumi, Jun Aida, Akira Aoki, Takanori Iwata
There have been limited studies with statistically sufficient sample sizes for assessment of suitable bone defect morphology for combination therapy with enamel matrix derivative (EMD) and bone grafting. The aim of this study was to investigate the appropriate feature of intrabony defects, such as bone defect angle (DA) and the containment by bony wall, for yielding the additional benefit of bone grafting
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Enhanced periodontal tissue healing via vascular endothelial growth factor expression following low-level erbium-doped: yttrium, aluminum, and garnet laser irradiation: In vitro and in vivo studies J. Periodontol. (IF 4.3) Pub Date : 2023-11-27 Shu Takemura, Koji Mizutani, Risako Mikami, Keita Nakagawa, Masahiro Hakariya, Eri Sakaniwa, Natsumi Saito, Hiromi Kominato, Daisuke Kido, Kohei Takeda, Akira Aoki, Takanori Iwata
This study aimed to investigate the effects of low-level erbium-doped: yttrium, aluminum, and garnet (Er:YAG) laser irradiation on periodontal tissue healing and regeneration through angiogenesis in vivo and in vitro studies.
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Mediating role of systemic inflammation in the association between heavy metals exposure and periodontitis risk J. Periodontol. (IF 4.3) Pub Date : 2023-11-21 Mi Du, Ke Deng, Qingqing Cai, Shixian Hu, Yuntao Chen, Shulan Xu, Geerten-Has E. Tjakkes, Shaohua Ge, Minghua Ge, An Li
This study evaluated the mediating role of systemic inflammation in the association between exposure to heavy metals and periodontitis in a nationwide sample of adults.
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Association of environmental polycyclic aromatic hydrocarbons exposure with periodontitis in NHANES 2009–2014: A mixtures approach J. Periodontol. (IF 4.3) Pub Date : 2023-11-21 Jinqiu Sun, Feifei Guo, Lin Wang, Fulei Han, Jia Yang, Shengli Gao
Polycyclic aromatic hydrocarbons (PAHs) can invade and cause harm to the human body through various pathways, but there is currently little research on the relationship between mixed-PAHs exposure and periodontitis. The purpose of this study was to examine the effects of mixed-urinary PAHs exposure on periodontitis in adults in the United States.
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Association between sequelae of COVID-19 with periodontal disease and obesity: A cross-sectional study J. Periodontol. (IF 4.3) Pub Date : 2023-11-21 Maísa Casarin, Francisco Hecktheuer Silva, Ana Flávia Leite Pontes, Betina Dutra Lima, Flavia Q. Pirih, Francisco Wilker Mustafa Gomes Muniz
To assess the sequelae of coronavirus disease 2019 (COVID-19) and associated factors, such as obesity and periodontitis in adults.
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Possible role of annexin A1/FPR2 pathway in COX2/NLRP3 inflammasome regulation in alveolar bone cells of estrogen-deficient female rats with diabetes mellitus J. Periodontol. (IF 4.3) Pub Date : 2023-11-21 Gisela Rodrigues Da Silva Sasso, Paulo Sérgio Cerri, Estela Sasso-Cerri, Manuel Jesus Simões, Cristiane Damas Gil, Rinaldo Florencio-Silva
Annexin A1 (ANXA1) and the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome play important roles in bone remodeling. However, expression profiles of these factors in bone cells under diabetes mellitus (DM) and estrogen-deficient conditions are poorly understood. This study investigated the immunoexpression of ANXA1 and its formyl peptide receptor 2 (FPR2), as well as
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Clinical and radiographic evaluation of the use of PRF, CGF, and autogenous bone in the treatment of periodontal intrabony defects: Treatment of periodontal defect by using autologous products J. Periodontol. (IF 4.3) Pub Date : 2023-11-20 Basem Alshujaa, Ahmet Cemil Talmac, Dicle Altindal, Anas Alsafadi, Abdullah Seckin Ertugrul
The purpose of this randomized clinical study was to clinically evaluate and compare the efficiencies of platelet-rich fibrin (PRF), concentrated growth factor (CGF) and autogenous bone graft (ABG) in the treatment of intrabony pockets and to assess the alveolar bone gain (AB gain) radiographically (panoramic and CBCT images).
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Extracellular adenosine triphosphate regulates inflammatory responses of periodontal ligament cells J. Periodontol. (IF 4.3) Pub Date : 2023-11-06 Maythwe Kyawsoewin, Jeeranan Manokawinchoke, Chutimon Termkwanchareon, Hiroshi Egusa, Thanaphum Osathanon, Phoonsuk Limraksasin
Various stimuli, that is, mechanical stresses or inflammation, induce the release of adenosine triphosphate (ATP) by human periodontal ligament cells (HPDLCs). Extracellular adenosine triphosphate (eATP) affects HPDLCs’ functions such as immunosuppressive action and inflammatory responses. Lipopolysaccharide (LPS) is the key factor involved in periodontal inflammation. However, the possible correlation
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Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats J. Periodontol. (IF 4.3) Pub Date : 2023-11-03 Wei Qiu, Qian Sun, Na Li, Zehao Chen, Hongle Wu, Zhao Chen, Xiaolan Guo, Fuchun Fang
Osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) is an essential event in alveolar bone regeneration. Oxidative stress may be the main inhibiting factor of hPDLSC osteogenesis. Superoxide dismutase 2 (SOD2) is a key antioxidant enzyme, but its effect on hPDLSC osteogenic differentiation is unclear.
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Suppression of subgingival bacteria by antimicrobial photodynamic therapy using transgingival irradiation: A randomized clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-11-01 Jun-ichiro Hayashi, Kohta Ono, Yuki Iwamura, Yasuyuki Sasaki, Tasuku Ohno, Ryoma Goto, Eisaku Nishida, Genta Yamamoto, Takeshi Kikuchi, Naoya Higuchi, Akio Mitani, Mitsuo Fukuda
Antimicrobial photodynamic therapy (aPDT) is an effective method for eradicating bacteria in periodontal therapy. Standard aPDT requires the insertion of a laser tip into a periodontal pocket, in which the direction of irradiation is limited. Therefore, we devised an aPDT method that uses a transgingival near-infrared wavelength and indocyanine green-encapsulated and chitosan-coated nanoparticles as
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Aggressive periodontitis in southwestern American Indian adolescents J. Periodontol. (IF 4.3) Pub Date : 2023-11-01 Thomas E. Rams, Adolfo Contreras, Jørgen Slots
This study determined the prevalence of aggressive (molar-incisor pattern) (Ag/MI) periodontitis and assessed the associated subgingival bacterial-herpesvirus microbiota in Pueblo Indian adolescents in the southwestern United States.
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Effects of a stabilized stannous fluoride dentifrice on clinical, immunomodulatory, and microbial outcomes in a human experimental gingivitis model J. Periodontol. (IF 4.3) Pub Date : 2023-10-27 Noah Fine, Abdelahhad Barbour, Kamini Kaura, Kristopher A. Kerns, Dandan Chen, Harsh M. Trivedi, Juliana Gomez, Amarpreet Sabharwal, Jeffrey S. McLean, Richard P. Darveau, Michael Glogauer
Stannous fluoride dentifrice is well established for its beneficial clinical effects. In this study, we evaluated the effects of stannous fluoride on inflammation and oral microbiome.
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Prevalence, risk indicators, and clinical characteristics of peri-implant mucositis and peri-implantitis for an internal conical connection implant system: A multicenter cross-sectional study J. Periodontol. (IF 4.3) Pub Date : 2023-10-17 Karin Apaza-Bedoya, Maria Elisa Galarraga-Vinueza, Bruna Barbosa Correa, Frank Schwarz, Marco Aurélio Bianchini, Cesar Augusto Magalhães Benfatti
Peri-implant disease prevalence is associated with a multifactorial etiology and distinct clinical characteristics of inflammation.
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Comparative evaluation of semaphorin-4D, peptidylarginine deiminase-2, and matrix metalloproteinase-8 levels of gingival crevicular fluid in periodontally healthy and Stage III periodontitis smoker and non-smoker patients before and after non-surgical periodontal therapy J. Periodontol. (IF 4.3) Pub Date : 2023-10-17 Aishwarya S. Ikhar, Rajashri A. Kolte, Abhay P. Kolte, Prachi R. Rathi, Dhanashree G. Ghoderao, Rahul N. Dahake
This study was designed to assess the influence of non-surgical periodontal therapy (NSPT) on gingival crevicular fluid (GCF) levels of semaphorin-4D (SEMA-4D), peptidylarginine deiminase-2 (PAD-2), and matrix metalloproteinase-8 (MMP-8) levels in periodontally healthy, Stage III periodontitis non-smoker and smoker patients.
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A comparison of Er,Cr:YSGG laser to minimally invasive surgical technique in the treatment of intrabony defects: Twelve-month results of a multicenter, randomized, controlled study J. Periodontol. (IF 4.3) Pub Date : 2023-10-17 Donald Clem, Rick Heard, Michael McGuire, E. Todd Scheyer, Chris Richardson, Gregory Toback, John C. Gunsolley, Nico Geurs
The purpose of this publication is to report on the 12-month clinical and radiographic results comparing the surgical use of the Er,Cr:YSGG laser (ERL) and minimally invasive surgical technique (MIST) for the treatment of intrabony defects in subjects with generalized periodontitis stage III, grade B.
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Relationship between C-reactive protein level and periodontitis and systemic diseases J. Periodontol. (IF 4.3) Pub Date : 2023-10-16 Jung-Hwa Lee, So-Jung Mun
Periodontitis affects systemic disease risk, although the relationship thereof in the context of different C-reactive protein (CRP) levels is not clear. This study investigated the association of periodontitis with systemic diseases according to high-sensitivity CRP (hs-CRP) level and sought to identify the risk of systemic diseases in patients with periodontitis.
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The associations of coffee consumption, coffee types, and caffeine metabolites with periodontitis: Results from NHANES 2009–2014 J. Periodontol. (IF 4.3) Pub Date : 2023-10-10 Qiansi Chen, Ruiyang Ge, Yuxuan Wu, Yuying Wu, Han Yang, Yiming Yu, Qingrong Deng, Yu Qiu, Baochang He, Fuhua Yan, Yanfen Li, Fa Chen
Coffee is one of the world's most popular beverages and is the main dietary source of caffeine for most people. The various molecular effects of caffeine suggest that it may enhance bone loss. The purpose of the present study was to investigate the relationship of coffee, coffee types, and caffeine metabolites with periodontitis.
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Association between antihyperlipidemic agents and the risk of chronic periodontitis in patients with hyperlipidemia: A population-based retrospective cohort study in Taiwan J. Periodontol. (IF 4.3) Pub Date : 2023-10-04 An-Yi Wang, Guan-Ling Lin, Joseph Jordan Keller, Li-Hsuan Wang
The lipid-lowering and anti-inflammatory effects of statins and fibrates may ameliorate periodontitis. Patients with hyperlipidemia tend to have a worse periodontal status. This study assessed the association between the use of statins/fibrates and the incidence of chronic periodontitis in patients with hyperlipidemia in Taiwan.
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The effect of a multicomponent oral care regimen on gingival inflammation: A randomized controlled clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-10-04 Guilherme C. L. S. do Amaral, Mohamed A. Hassan, Luciana Saraiva, Laís Y. S. Nakao, Marinella Holzhausen, Zilson M. Malheiros, Bernal Stewart, Giuseppe A. Romito, Cristina C. Villar
Oral care regimens can be explored to improve oral health in patients with gingivitis. This study aimed to evaluate the efficacy of a multicomponent oral care regimen with a dual zinc plus arginine (DZA) toothpaste and cetylpyridinium chloride with zinc lactate (CPC + Zn) mouthwash in reducing gingival bleeding in patients with gingivitis.
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Association between missing teeth number and all-cause and cardiovascular mortality: NHANES 1999–2004 and 2009–2014 J. Periodontol. (IF 4.3) Pub Date : 2023-10-04 Ruming Shen, Shuaijie Chen, Jiayi Shen, Lingchun Lv, Tiemin Wei
The association between tooth loss and all-cause and cardiovascular mortality requires further investigation.
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Comparative transcriptome analysis of periodontitis and peri-implantitis in human subjects J. Periodontol. (IF 4.3) Pub Date : 2023-10-03 Jung-Min Oh, Yeongjoo Kim, Hyojae Son, Yun Hak Kim, Hyun-Joo Kim
Peri-implantitis is similar to periodontitis, but there are some differences. For the effective control of peri-implantitis, it is necessary to clarify its similarities and differences with periodontitis in terms of gene expression.
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Local application of gingiva-derived mesenchymal stem cells on experimental periodontitis in rats J. Periodontol. (IF 4.3) Pub Date : 2023-10-03 Yunus Emre Balaban, Sema Akbaba, Serife Buket Bozkurt, Arda Buyuksungur, E. Ece Akgun, Zeynep Burcin Gonen, Hasan Salkin, Aysen Tezcaner, Sema S. Hakki
Stem cell-based approaches in regenerative periodontal therapy have been used in different experimental models. In this study, the effect of local application of gingival mesenchymal stem cells (GMSC) in fibroin/chitosan oligosaccharide lactate hydrogel (F/COS) on periodontal regeneration was evaluated using experimental periodontitis model in rats.
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An in vitro dynamic bioreactor model for evaluating antimicrobial effectiveness on periodontal polymicrobial biofilms: a proof-of-concept study J. Periodontol. (IF 4.3) Pub Date : 2023-09-19 Srinivas Sulugodu Ramachandra, Fekade Bruck Sime, Saiyuri Naicker, Pingping Han, Ryan SB Lee, Steven C Wallis, Jason A Roberts, Sašo Ivanovski
The aim of this study was to investigate an in vitro dynamic bioreactor model by evaluating the antimicrobial effect of clinically relevant amoxicillin doses on polymicrobial microcosm biofilms derived from subgingival plaque.
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J-shaped association between systemic immune-inflammation index and periodontitis: Results from NHANES 2009–2014 J. Periodontol. (IF 4.3) Pub Date : 2023-09-15 Ruoyan Cao, Chen Li, Fengxue Geng, Yaping Pan
To examine the relationship between the systemic immune-inflammation index (SII) and periodontitis and to investigate possible effect modifiers.
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Impact of surface characteristics on the peri-implant microbiome in health and disease J. Periodontol. (IF 4.3) Pub Date : 2023-09-04 Khaled Sinjab, Shriya Sawant, Alice Ou, J. Christopher Fenno, Hom-Lay Wang, Purnima Kumar
Because little is known about the impact of implant surface modifications on the peri-implant microbiome, we aimed to examine peri-implant communities in various surface types in order to better understand the impact of these surfaces on the development of peri-implantitis (PI).
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Alveolar mucosal cell spheroids promote extraction socket healing and osseous defect regeneration J. Periodontol. (IF 4.3) Pub Date : 2023-08-02 Che-Chang Tu, Zhao-Cheng Zheng, Nai-Chen Cheng, Jiashing Yu, Wei-Chiu Tai, Yi-Xuan Pan, Po-Chun Chang
Alveolar mucosa could be a promising source of mesenchymal stem cells (MSCs) for regeneration therapeutics because it exhibits faster healing potential and can be easily collected with minimal periodontal disturbance. This study aimed to evaluate the potential of alveolar mucosal cell (AMC) spheroids for promoting extraction socket healing and calvarial osseous defect regeneration.
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Influences of standardized clinical probing on peri-implant soft tissue seal in a situation of peri-implant mucositis: A histomorphometric study in dogs J. Periodontol. (IF 4.3) Pub Date : 2023-07-29 Rong Cai, Yi Liu, Xinge Wang, Hongbo Wei, Jin Wang, Yanze Cao, Jiaqi Lei, Dehua Li
Clinical probing is commonly recommended to evaluate peri-implant conditions. In a situation of peri-implant mucositis or peri-implantitis, the peri-implant seal healing from the disruption of soft tissue caused by probing has not yet been studied. This study aimed to investigate soft tissue healing after standardized clinical probing around osseointegrated implants with peri-implant mucositis in a
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Temporal and spatial effects on C-reactive protein's regulation of inducible nitric oxide synthase production in periodontal disease J. Periodontol. (IF 4.3) Pub Date : 2023-07-29 Lingjie Li, Lurong Jia, Siyu Hou, Tingwei Zhang, Mengjiao Zhou, Tao Chen, Jinlin Song
Inducible nitric oxide synthase (iNOS) is associated with inflammation and osteoclastic differentiation in periodontal disease. This study was conducted to compare the time-dependent variation in iNOS production between the gingiva and other periodontal tissues and to explore the potential association with C-reactive protein (CRP) in early periodontal disease.
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Clinicoradiographic comparative evaluation of 1% melatonin gel plus platelet-rich fibrin over platelet-rich fibrin alone in treatment of Grade II furcation defects: A randomized controlled double-blind clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-07-29 Srushti K. Dhande, Surekha R. Rathod, Abhay P. Kolte, Vrushali N. Lathiya, Palak A. Kasliwal
The present study aims to evaluate and compare the effects of 1% melatonin gel plus platelet-rich fibrin (PRF) and PRF alone in treatment of furcation defects, clinically and radiographically using cone-beam computed tomography.
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Sex differences in the association between dual-energy x-ray absorptiometry-measured body composition and periodontitis J. Periodontol. (IF 4.3) Pub Date : 2023-07-28 Peijun Zhu, An Li, Qingqing Cai, Yuntao Chen, Yang Liu, Harriët Jager-Wittenaar, Geerten-Has E. Tjakkes, Shulan Xu
A positive association between obesity based on body mass index (BMI) and periodontitis has been reported. Fat tissue-related systemic inflammation acts as the link to periodontal comorbidities of obesity. However, the BMI is unable to distinguish fat and fat-free tissues. More precise measures are required to evaluate body composition, including fat and fat-free tissues. This study aimed to determine
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Activation of periodontal ligament cell cytodifferentiation by juxtacrine signaling from cementoblasts J. Periodontol. (IF 4.3) Pub Date : 2023-07-26 Keigo Sawada, Junpei Shimomura, Masahide Takedachi, Mari Murata, Chiaki Morimoto, Kohsuke Kawasaki, Kazuma Kawakami, Tomoaki Iwayama, Shinya Murakami
New cementum forms from existing cementum during periodontal tissue regeneration, indicating that cementoblasts may interact with progenitor cells in the periodontal ligament to enhance cementogenesis. However, the molecular mechanisms of this process are currently unknown. This study aims to clarify the role of cell-cell interactions between cementoblasts and periodontal ligament cells in differentiation
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Evidence linking the association of periodontal viruses and pentraxins in periodontitis patients with coronary artery disease J. Periodontol. (IF 4.3) Pub Date : 2023-07-22 Paavai Ilango, Jaideep Mahendra, Little Mahendra, Sanjay M. Cherian, Vasugi Suresh, Arulpari Mahalingam, V. Vinoth Khanna, Ayswarya V Vummidi, Abirami Thanigaimalai, Pavithra H. Dave
Although there is ample evidence in the literature supporting a significant positive association between key periodontal pathogens and established inflammatory markers of periodontitis and coronary artery disease (CAD), their exact role remain unclear. Especially, the role of viruses in the etiology and specific biomarkers have not been validated. Thus, the current study aims to evaluate the role of
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Bioactive glass and arginine dentifrices reduce root sensitivity during daily activities following non-surgical periodontal therapy: A randomized clinical trial. J. Periodontol. (IF 4.3) Pub Date : 2023-07-20 Chantrakorn Champaiboon, Napassorn Ongphichetmetha, Attawood Lertpimonchai
Evidence on the efficacy of calcium sodium phosphosilicate (CSPS) and arginine dentifrices on reducing root sensitivity (RS) following non-surgical periodontal therapy (NSPT) is limited. The aim of the study was to compare the efficacy of these dentifrices in reducing RS during daily activities in patients undergoing NSPT.
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Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes J. Periodontol. (IF 4.3) Pub Date : 2023-07-21 Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, Sathiyapriya Viswanathan, Renuka Devy Thirumalai Nathan
Aberrant deoxyribonucleic acid (DNA) contributes to inflammasome orchestrated progression of chronic inflammatory diseases like diabetes and periodontitis. The purpose of the present study was to estimate salivary levels of DNA sensing inflammasomes, absent in melanoma 2 (AIM2), interferon γ inducible protein (IFI16), and cytokine interleukin 18 (IL18) in individuals with periodontitis, diabetes, and
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Multiplicative effect of stress and poor sleep quality on periodontitis: A university-based cross-sectional study J. Periodontol. (IF 4.3) Pub Date : 2023-07-21 Crystal Marruganti, Carlo Gaeta, Mario Romandini, Edoardo Ferrari Cagidiaco, Stefano Parrini, Nicola Discepoli, Simone Grandini
The aim of this study was to evaluate the association of perceived stress and poor sleep quality with periodontitis in a university-based cohort of individuals.
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Association between periodontitis and mortality of patients with cardiovascular diseases: A cohort study based on NHANES J. Periodontol. (IF 4.3) Pub Date : 2023-07-19 Fangman Chen, Yansong Song, Weiqi Li, Hao Xu, Hongxia Dan, Qianming Chen
The association between periodontitis and cardiovascular disease (CVD) has been widely explored, but little is known about the effect of periodontitis on the mortality of CVD patients. This study aims to clarify the effect of periodontitis on all-cause and cause-specific mortality of CVD patients.
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Patients with inflammatory bowel disease have more oral health problems and higher costs of professional dental care than healthy controls: The Periodontitis Prevalence in ulcerative Colitis and Crohn disease (PPCC) case-control study J. Periodontol. (IF 4.3) Pub Date : 2023-07-19 Kristina Bertl, Johan Burisch, Nikolaos Pandis, Björn Klinge, Andreas Stavropoulos
To describe the frequency and impact of oral lesions and professional dental care costs in patients with inflammatory bowel disease (IBD) (i.e., Crohn disease [CD] or ulcerative colitis [UC]) compared to matched controls).
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Salivary inflammatory burden in pre- and postmenopausal women: Associations with body mass index, patient-reported health, serum cytokines, and periodontal parameters J. Periodontol. (IF 4.3) Pub Date : 2023-07-18 Nil Yakar, Nagihan Bostanci, Güven Özdemir, Harika Atmaca, Asena Türedi, Çağdaş Şahin, Timur Köse, Gülnur Emingil
The decline of estrogen levels during menopause impacts weight, mood, and overall health, both orally and systemically. This study assessed salivary levels of tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), IL-10, and IL-7 in postmenopausal (PMW) and regularly menstruating premenopausal (RMPW) women, while considering serum cytokine levels, body mass index (BMI), periodontal health, and
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Association between clusters of antibodies against periodontal microorganisms and Alzheimer disease mortality: Evidence from a nationally representative survey in the USA J. Periodontol. (IF 4.3) Pub Date : 2023-07-15 Anwar T. Merchant, Longgang Zhao, Eric Mishio Bawa, Fanli Yi, Nadeesha P. Vidanapathirana, Matthew Lohman, Jiajia Zhang
Alzheimer disease (AD) has been linked with periodontal microorganisms such as Porphyromonas gingivalis in observational and mechanistic studies. IgG antibodies against periodontal microorganisms which are markers of past and current periodontal infection have been correlated with cognitive impairment. We examined associations between empirically derived groups of 19 IgG antibodies against periodontal
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Impact of N-terminal pro-B-type natriuretic peptide and related inflammatory biomarkers on periodontal treatment outcomes in patients with periodontitis: An explorative human randomized-controlled clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-07-11 Gaetano Isola, Gianluca Martino Tartaglia, Simona Santonocito, Alessandro Polizzi, Ray C. Williams, Vincenzo Iorio-Siciliano
N-terminal portion of the B-type natriuretic propeptide (NT-proBNP) has potentially been shown to play an important role in the development of periodontitis and cardiovascular disease (CVD). This study evaluated the efficacy of periodontal treatment on NT-proBNP and related CVD biomarkers and explored whether subjects harboring high NT-proBNP at baseline showed increased clinical benefits with the
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Parkinson's disease is positively associated with periodontal inflammation J. Periodontol. (IF 4.3) Pub Date : 2023-07-11 Melis Yilmaz, Ekin Yay, Nur Balci, Hilal Toygar, Basak Bolluk Kılıc, Ali Zirh, Carla Alvarez Rivas, Alpdogan Kantarci
Parkinson's disease (PA) affects 1% of the global population above 60 years. PA pathogenesis involves severe neuroinflammation that impacts systemic and local inflammatory changes. We tested the hypothesis that PA is associated with periodontal tissue inflammation promoting a greater systemic inflammatory burden.
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Prenyltransferase gene expression reveals an essential role of prenylation for the inflammatory response in human gingival fibroblasts J. Periodontol. (IF 4.3) Pub Date : 2023-07-11 Daniel Diehl, Anton Friedmann, Hagen S. Bachmann
Prenyltrasferases (PTases) are a class of enzymes known to be responsible for promoting posttranslational modification at the carboxyl terminus of proteins containing a so-called CaaX-motif. The process is responsible for proper membrane localization and the appropriate function of several intracellular signaling proteins. Current research demonstrating the pathomechanistic importance of prenylation
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Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo-controlled clinical trial J. Periodontol. (IF 4.3) Pub Date : 2023-07-13 Brenda Laky, Corinna Bruckmann, Julian Blumenschein, Gerlinde Durstberger, Hady Haririan
The aim of this double-blind randomized placebo-controlled clinical trial was to evaluate the efficacy of a multinutrient supplement as an add-on therapy to scaling and root planing for patients with periodontitis.
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Study on the effect of protein lysine lactylation modification in macrophages on inhibiting periodontitis in rats J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 Xiaochuan Liu, Jinsi Wang, Mo Lao, Fuyu Liu, Hong Zhu, Kenny Man, Jingying Zhang
Protein lysine lactylation (Kla) has been proved to be closely related to inflammatory diseases, but its role in periodontitis (PD) is unclear. Therefore, this study aimed to establish the global profiling of Kla in PD models in rats.
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Upper lip characteristics and associated excessive gingival display etiologies in adults: Race and sex differences J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 Dimitris N. Tatakis, Vanessa Paramitha, Wei-En Lu, Xiaohan Guo
This cross-sectional study aimed to examine upper lip (UL) and smile characteristics and soft tissue excessive gingival display (EGD) etiologies (hypermobile upper lip [HUL], altered passive eruption [APE], and short upper lip [SUL]) in a nondental adult population and to analyze interracial (Black and White) and intergender differences.
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Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 Ömer Alperen Kırmızıgül, Arife Sabanci, Faruk Dişli, Sedat Yıldız, Michael R Milward, Kübra Aral
Mitochondria and endoplasmic reticulum are key cellular organelles and create contact sites (mitochondria-endoplasmic reticulum contact [MERC]), which plays a major role in calcium metabolism, apoptotic processes, and inflammation. Previously, proteins that have been associated with these MERC contact sites mitofusin-1 (MFN1) and mitofusin-2 (MFN2) have been found to be downregulated in periodontal
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A tribute to Dr. Henry Greenwell: A southern gentleman and periodontal legend J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 George Mandelaris, Hom-Lay Wang
1952–2023 On June 1, 2023, periodontology lost a man who helped shape what our specialty has become. A passing without fanfare, without accolades or entitlement, and without knowledge of his ailment by most in our community—and that is exactly the way he wanted it. Henry Greenwell was born in Shelbyville, Kentucky. He began his college education at Tulane University, but soon his “old Kentucky home”
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The effect of smoking on clinical and biochemical early healing outcomes of coronally advanced flap with connective tissue graft: Prospective cohort study J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 Duygu Taş, Şivge Kurgan, Zeliha Güney, Muhittin A. Serdar, Dimitris N. Tatakis
This study aimed to determine the effects of smoking on early (≤3 months) clinical outcomes and relevant molecular biomarkers following root coverage surgery.
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Periodontal ligament-associated protein-1 promotes osteoclastogenesis in mice by modulating TGF-β1/Smad1 pathway J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 Shuang Liu, Xijiao Yu, Qiushuang Guo, Shuaiqi Zhao, Kaixian Yan, Meng Hou, Fuxiang Bai, Shu Li
Periodontal ligament-associated protein-1 (PLAP-1), an important target molecule of osteoarthritis research, may affect alveolar bone resorption. The aim of our study was to comprehensively and systematically detect the effect of PLAP-1 on alveolar bone resorption and the underlying mechanism in PLAP-1 knockout mouse models.
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Probing pocket depth reduction after non-surgical periodontal therapy: Tooth-related factors J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 Nils Werner, Katrin Heck, Elias Walter, Christina Ern, Caspar Victor Bumm, Matthias Folwaczny
To investigate tooth-related factors that influence the reduction of probing pocket depths (PPD) after non-surgical periodontal therapy (NST).
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Influence of the level of compliance with preventive maintenance therapy upon the prevalence of peri-implant diseases J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 Francesco Di Leone, Gonzalo Blasi, Ettore Amerio, Cristina Valles, José Nart, Alberto Monje
A study was made to evaluate peri-implant conditions in compliers and erratic compliers with peri-implant maintenance therapy (PIMT), and to assess the role of site-specific confounders.
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Analysis of risk factors for early crestal bone loss in osseointegrated, submerged implants prior to restoration J. Periodontol. (IF 4.3) Pub Date : 2023-07-12 Bansari Shah, Himabindu Dukka, Sara Alhachache, Margaret Hill, Guo-Liang Cheng, Michael Sekula
Evidence on the etiology behind bone loss around submerged, prosthetically nonloaded implants is still limited. The long-term stability and success of implants with early crestal bone loss (ECBL), especially when placed as two-stage implants, is uncertain. Hence, the aim of this retrospective study is to analyze the potential patient-level, tooth- and implant-related factors for ECBL around osseointegrated
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Polymorphism in epigenetic regulating genes in relation to periodontitis, number of teeth, and levels of high-sensitivity C-reactive protein and glycated hemoglobin: The Tromsø Study 2015-2016 J. Periodontol. (IF 4.3) Pub Date : 2023-06-29 Farah Asa'ad, Natalia Petrenya, Birgitta Jönsson, Gro Eirin Holde, Nils Oscarson, Elin Hadler-Olsen, Alexandre R. Vieira, Max Petzold, Lena Larsson
The aim of this study was to investigate the association between periodontitis and four single nucleotide polymorphisms (SNPs) in genes involved in epigenetic regulation of DNA, and between these same SNPs and tooth loss, high-sensitivity C-reactive protein (hs-CRP), and glycated hemoglobin (HbA1c) levels.
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Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis J. Periodontol. (IF 4.3) Pub Date : 2023-06-18 Deniz Sunnetci-Akkoyunlu, Esra Guzeldemir-Akcakanat, Begum Alkan, Busra Gurel, V. Merve Balta-Uysal, Emel Akgun, Ahmet Tarik Baykal, Vakur Olgac
Our previous study explored the molecular signatures of generalized aggressive periodontitis (GAgP) using gingival tissues through omics-based-whole-genome transcriptomic analysis. This continuation study aimed to investigate the whole protein profiling of these gingival samples through liquid chromatography-mass spectroscopy/mass spectroscopy (LC-MS/MS) analysis and to validate the identified proteins
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Non-invasive assessment of peri-implant mucosal thickness: A cross-sectional study J. Periodontol. (IF 4.3) Pub Date : 2023-06-18 Emilio Couso-Queiruga, Clemens Raabe, Urs C. Belser, Daniel Buser, Gustavo Avila-Ortiz, Diogo Moreira Rodrigues, Vivianne Chappuis
This study aimed to evaluate the reliability and reproducibility of different non-invasive methods for the assessment of peri-implant mucosal thickness.
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Oral health-related quality of life among women early postpartum: A cross-sectional study J. Periodontol. (IF 4.3) Pub Date : 2023-06-16 Rana Badewy, Elaine Cardoso, Michael Glogauer, Michael Sgro, Kristin L. Connor, Jim Yuan Lai, Richard P. Bazinet, Howard C. Tenenbaum, Amir Azarpazhooh
Periodontal diseases can negatively impact the oral health-related quality of life (OHRQoL) of pregnant women. This study investigates the association between maternal oral inflammatory load (OIL), sociodemographic characteristics, and the OHRQoL in postpartum women.
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Differential effects of resolvin D1 and resolvin E1 on cementoblast function J. Periodontol. (IF 4.3) Pub Date : 2023-06-15 Serife Buket Bozkurt, Sema Sezgin Hakki, Alpdogan Kantarci
Resolvins are endogenous mediators of the resolution of inflammation. They are derived from omega-3 polyunsaturated fatty acid precursors. Resolvin D1 (RvD1) and Resolvin E1 (RvE1) are the best-characterized members for actively promoting periodontal regeneration in experimental animal models. Here, we evaluated the efficacy of RvD1 and RvE1 on cementoblasts, the key cells involved in dental cementum
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Reliability assessment of the 2018 classification case definitions of peri-implant health, peri-implant mucositis, and peri-implantitis J. Periodontol. (IF 4.3) Pub Date : 2023-06-15 Lorenzo Marini, Cristiano Tomasi, Rodolfo Gianserra, Filippo Graziani, Luca Landi, Mauro Merli, Luigi Nibali, Mario Roccuzzo, Nicola M. Sforza, Maurizio S. Tonetti, Federico Deli, Piero Papi, Bianca Di Murro, Mariana A. Rojas, Andrea Pilloni
The purpose of this study was to evaluate the reliability and accuracy in the assignment of the case definitions of peri-implant health and diseases according to the 2018 Classification of Periodontal and Peri-implant Diseases and Conditions.