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Using Trajectories of Bedside Vital Signs to Identify COVID-19 Subphenotypes Chest (IF 9.6) Pub Date : 2023-09-23 Sivasubramanium V. Bhavani, Chad Robichaux, Philip A. Verhoef, Matthew M. Churpek, Craig M. Coopersmith
Background Trajectories of bedside vital signs have been used to identify sepsis subphenotypes with distinct outcomes and treatment responses. The objective of this study is to validate the vitals trajectory model in a multicenter cohort of hospitalized COVID-19 patients and to evaluate the clinical characteristics and outcomes of the resulting subphenotypes. Research Question Can the trajectory of
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Prevalence, Risk factors, Clinical features, and Outcome of Influenza-Associated Pulmonary Aspergillosis (IAPA) in Critically Ill Patients: a systematic review and meta-analysis Chest (IF 9.6) Pub Date : 2023-09-22 Lawrence Y. Lu, Hui Min Lee, Andrew Burke, Gianluigi Li Bassi, Antoni Torres, John F. Fraser, Jonathon P. Fanning
Abstract not available
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Discrimination predicts suboptimal adherence to continuous positive airway pressure treatment and mediates Black-White differences in use Chest (IF 9.6) Pub Date : 2023-09-22 Douglas M. Wallace, Andrea Barnes Grant, Zuzana Belisova-Gyure, Matthew Ebben, Omonigho M. Bubu, Dayna A. Johnson, Girardin Jean-Louis, Natasha J. Williams
Background Although racial and ethnic differences in continuous positive airway pressure (CPAP) adherence for obstructive sleep apnea (OSA) are widely established, no studies have examined the influence of perceived racial discrimination on CPAP usage, to our knowledge. Research Questions: 1) Do Black adults with OSA report experiencing greater amounts of discrimination than non-Hispanic White adults
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Accuracy of Cytological vs. Histological Specimens for Assessment of PD-L1 Expression in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis Chest (IF 9.6) Pub Date : 2023-09-20 Pattraporn Tajarernmuang, Felipe Aliaga, Amr J. Alwakeel, Gamuchirai Tavaziva, Kimberly Turner, Dick Menzies, Hangjun Wang, Linda Ofiara, Andrea Benedetti, Anne V. Gonzalez
Background Programmed death-ligand 1 (PD-L1) expression on tumor cells, evaluated by immunohistochemistry, guides the use of immunotherapy in advanced non-small cell lung cancer (NSCLC). Research Question What is the sensitivity and specificity of PD-L1 testing performed in cytological vs. paired histological specimens, in patients with non-small cell lung cancer? Study Design and Methods The MEDLINE
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Effects of Sirolimus on Anti-SARS-CoV2 Vaccination in Patients with LAM Chest (IF 9.6) Pub Date : 2023-09-20 Tat’Yana Worthy, Amanda Jones, Bennett Yang, Hiroko Ishiwata-Endo, Nishant Gupta, Joel Moss
Abstract not available
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Epidemiology of COVID 19-Associated Mucormycosis in the United States Chest (IF 9.6) Pub Date : 2023-09-19 Aditya Sharma, Aditi Sharma, Ayman O. Soubani
Abstract not available
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AHL score for predicting mortality risk in patients with pulmonary tuberculosis Chest (IF 9.6) Pub Date : 2023-09-17 Takeshi Osawa, Masato Watanabe, Kozo Morimoto, Takashi Yoshiyama, Shuichi Matsuda, Keiji Fujiwara, Koji Furuuchi, Masafumi Shimoda, Masashi Ito, Tatsuya Kodama, Fumiko Uesugi, Masao Okumura, Yoshiaki Tanaka, Yuka Sasaki, Hideo Ogata, Hajime Goto, Shoji Kudoh, Ken Ohta
Background A clinically applicable mortality-risk prediction system for pulmonary tuberculosis may improve treatment outcomes, but no easy-to-calculate and accurate score has yet been reported. We aimed to construct a simple and objective disease-severity score for patients with pulmonary tuberculosis. Research Question Does a clinical score consisting of simple objective factors predict the mortality
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Oxygen therapy in patients with intermediate-risk acute pulmonary embolism: a randomized trial Chest (IF 9.6) Pub Date : 2023-09-16 Deisy Barrios, Diego Durán, Carmen Rodríguez, Jorge Moisés, Ana Retegui, José Luis Lobo, Raquel López, Leyre Chasco, Luis Jara-Palomares, Alfonso Muriel, Remedios Otero-Candelera, Pedro Ruiz-Artacho, Manuel Monreal, Behnood Bikdeli, David Jiménez
Background The effect of supplemental oxygen therapy in patients with intermediate-risk pulmonary embolism (PE) who do not have hypoxemia at baseline is uncertain. Research Question Does supplemental oxygen improve echocardiographic parameters in non-hypoxemic patients with intermediate-risk PE? Study Design and Methods This pilot trial randomly assigned non-hypoxemic patients with stable PE and echocardiographic
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Risk Stratification in Pulmonary Arterial Hypertension: Perhaps Simple Is Not Best? Chest (IF 9.6) Pub Date : 2023-09-12 Charles Fauvel, R. James White, Rebecca R. Vanderpool, Roberto Badagliacca, Tobore Tobore, Mohammad Rahman, Carmine Dario Vizza, Shili Lin, Allen D. Everett, Scott H. Visovatti, Raymond L. Benza
Abstract not available
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Evaluation of the double-tracer gas single-breath washout test in a pediatric field study Chest (IF 9.6) Pub Date : 2023-09-15 Anne-Christianne Kentgens, Johanna M. Kurz, Rebeca Mozun, Jakob Usemann, Eva S.L. Pedersen, Claudia E. Kuehni, Philipp Latzin, Alexander Moeller, Florian Singer
Background The early-life origins of chronic pulmonary diseases are thought to arise in peripheral small airways. Predictors of ventilation inhomogeneity, a proxy of peripheral airway function, are understudied in schoolchildren. Research Question Is the double-tracer gas single-breath washout (DTG-SBW) measurement feasible in a pediatric field study setting? What are the predictors of the DTG-SBW
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2023 Canadian Thoracic Society Guideline on Pharmacotherapy in Patients With Stable COPD Chest (IF 9.6) Pub Date : 2023-09-09 Jean Bourbeau, Mohit Bhutani, Paul Hernandez, Shawn D. Aaron, Marie-France Beauchesne, Sophie B. Kermelly, Anthony D’Urzo, Avtar Lal, François Maltais, Jeffrey D. Marciniuk, Sunita Mulpuru, Erika Penz, Don D. Sin, Anne Van Dam, Joshua Wald, Brandie L. Walker, Darcy D. Marciniuk
Chronic obstructive pulmonary disease patient care must include confirming a diagnosis with postbronchodilator spirometry. Because of the clinical heterogeneity and the reality that airflow obstruction assessed by spirometry only partially reflects disease severity, a thorough clinical evaluation of the patient should include assessment of symptom burden and risk of exacerbations that permits the implementation
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Eosinophils in Bronchiectasis: A U-Turn for Bronchiectasis Management Chest (IF 9.6) Pub Date : 2023-09-07 Jennifer Pollock, Pieter C. Goeminne
Abstract not available
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Sharing More Than Space: The Heart and Lungs Chest (IF 9.6) Pub Date : 2023-09-07 Emily S. Wan
Abstract not available
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Predicting ICU Outcomes: Beyond Severity Scores Chest (IF 9.6) Pub Date : 2023-09-07 Hans Flaatten, Michael Beil
Abstract not available
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The Proton Is Not Enough: Opportunities of Combined Multinuclear MRI for Lung Functional Imaging Chest (IF 9.6) Pub Date : 2023-09-07 Mark O. Wielpütz
Abstract not available
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Lung Transplantation Training in North America: Bridging the Gap Chest (IF 9.6) Pub Date : 2023-09-07 Hakim Azfar Ali, Deborah Jo Levine
Abstract not available
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Post-Acute Sequelae of SARS-CoV-2: More Than Deconditioning Chest (IF 9.6) Pub Date : 2023-09-07 Phillip Joseph, Inderjit Singh
Abstract not available
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The Pearls and Pitfalls of a Migrating Bullet Embolus Chest (IF 9.6) Pub Date : 2023-09-07 Andrew F. Sabour, Lance Horner, Geoffrey Douglas, Arthur O. Romero, Carmen Flores, Joseph T. Carroll
Venous bullet embolism is an exceedingly rare trauma diagnosis that presents diagnostic and therapeutic challenges. We present the case of a 32-year-old man who sustained multiple gunshot wounds with a venous bullet embolism to the right pulmonary artery. Imaging at first demonstrated a bullet lodged within the right lower lobe. The patient underwent multiple bronchoscopies and ultimately was found
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Fatigue, Chest Tightness, and Heart Murmur: A Rare Congenital Valvular Abnormality Chest (IF 9.6) Pub Date : 2023-09-07 Tienan Chen, Tingting Wang, Yingqun Yan, Shuai Qiao, Tong Liu, Guangping Li, Huaying Fu
Abstract not available
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Unveiling Many Clinicopathologic Entities and Causes Within COPD Using CT Scan Chest (IF 9.6) Pub Date : 2023-09-07 Vasilios Tzilas, Bilal F. Samhouri, Thomas E. Hartman, Jay H. Ryu
Abstract not available
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Hydrophobia (Fear of Fluids) in Septic Shock Does Not Pay! Chest (IF 9.6) Pub Date : 2023-09-07 H. Bryant Nguyen
Abstract not available
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Diagnosing Pediatric ARDS Still Requires Clinical Judgment Chest (IF 9.6) Pub Date : 2023-09-07 Robinder G. Khemani, Nadir Yehya
Abstract not available
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Mechanisms of Exercise Intolerance in Chronic Heart Failure With Preserved Ejection Fraction: Challenging the Traditional Hypothesis Chest (IF 9.6) Pub Date : 2023-09-07 Bharathi Upadhya, Dalane W. Kitzman
Abstract not available
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Older Adult Woman in a Coma After Acute Laryngitis Chest (IF 9.6) Pub Date : 2023-09-07 Alexander Landerl, Irina Covaliova, Christoph Camille Ganter, Stefano Mancini, Sascha David, Rea Andermatt
Case Presentation A 72-year-old woman with a history of adenocarcinoma of the lung, for which she was receiving tyrosine kinase inhibitor therapy with osimertinib, was admitted to the ED because of clinical deterioration with extreme fatigue and fever. She was already receiving antibiotic therapy initiated by her general practitioner because of symptoms of an upper respiratory tract infection. She
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Unexpected Diffuse Alveolar Hemorrhage After Bronchoscopy Chest (IF 9.6) Pub Date : 2023-09-07 Saya Tsukida, Satoshi Watanabe, Masato Hongo, Yuya Murase, Yoshihiro Yamamoto, Kazumasa Kase, Nanao Terada, Hayato Koba, Yuichi Tambo, Seiji Yano
Case Presentation A 71-year-old woman sought treatment for a nonproductive cough. The patient had experienced no episodes of hemoptysis or shortness of breath. Her illness history included lumbago and dry mouth. The patient did not smoke and had no significant family medical history or medication use. She had no allergies to any food or drugs. Blood test results, including a CBC count, biochemical
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A 74-Year-Old Man With Dyspnea Chest (IF 9.6) Pub Date : 2023-09-07 Ibrahim Khatim, Marc A. Judson, Arkar Htoo, Amit Chopra
Case Presentation A 74-year-old man presented to the ED with progressive dyspnea, orthopnea, and bilateral leg swelling for 2 months. He denied cough, hemoptysis, fever, night sweats, or weight loss. He had history of COPD and chronic atrial fibrillation. He had a 50 pack-year smoking history and had quit 7 years prior to presentation.
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Albumin Should Be Remembered When Patients With Septic Shock Are Resuscitated Chest (IF 9.6) Pub Date : 2023-09-07 Xiaoyong Yang, Lei Yang
Abstract not available
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Exertional Desaturation During the 6-Minute Walk Test Versus Daily Life in People With Fibrotic Interstitial Lung Disease Chest (IF 9.6) Pub Date : 2023-09-01 Mariana Hoffman, Angela T. Burge, Nick Wong, Christine F. McDonald, Daniel C. Chambers, Ian Glaspole, John A. Mackintosh, Magnus Ekstrom, Magnus Sköld, Nicole SL. Goh, Tamera J. Corte, Anne E. Holland
Abstract not available
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Glycated Haemoglobin Trajectories and their Association with Treatment Outcomes among Pulmonary Tuberculosis Cases in India - A Prospective Cohort Study Chest (IF 9.6) Pub Date : 2023-09-04 Geeta Pardeshi, Vidya Mave, Sanjay Gaikwad, Dileep Kadam, Madhusudan Barthwal, Nikhil Gupte, Sachin Atre, Sona Deshmukh, Jonathan E. Golub, Akshay Gupte
Background Transient hyperglycemia is commonly seen during tuberculosis treatment, yet its association with unfavorable treatment outcomes is unclear. Research question Is there an association between glycated Haemoglobin (HbA1c) trajectories and tuberculosis treatment outcomes? Study design and methods Adults with pulmonary tuberculosis were prospectively evaluated for 18 months after their second
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Outcomes of intermittent multi-drug intravenous therapy for refractory Mycobacterium abscessus pulmonary disease Chest (IF 9.6) Pub Date : 2023-09-03 Yunjoo Im, Su-Young Kim, Dae Hun Kim, Byung Woo Jhun
BACKGROUND No studies have reported therapies for the management of patients with refractory Mycobacterium abscessus pulmonary disease (MAB-PD). We implemented intermittent multi-drug intravenous therapy (IMIT) through repeated hospitalizations for MAB-PD patients who were refractory to antibiotics for over 12 months. RESEARCH QUESTION What are the effects of IMIT on patients with refractory MAB-PD
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Is tobacco use associated with risk of recurrence and mortality among people with tuberculosis? A systematic review and meta-analysis Chest (IF 9.6) Pub Date : 2023-08-29 Aishwarya Lakshmi Vidyasagaran, Anne Readshaw, Melanie Boeckmann, Alexander Jarde, Faraz Siddiqui, Anna-Marie Marshall, Janita Akram, Jonathan E. Golub, Kamran Siddiqi, Omara Dogar
Background Associations between smoking and poor tuberculosis (TB) treatment outcomes are well documented. However, for important outcomes such as TB recurrence/relapse and mortality-during-treatment, as well as for associations with smokeless tobacco (ST), the evidence is not systematically summarised. Research Question Is tobacco use associated with risk of poor treatment outcomes among people with
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Epidemiology and clinical patterns of Lung Abscesses in ICU: A French multicenter retrospective study Chest (IF 9.6) Pub Date : 2023-08-29 Vinca Montmeat, Vincent Bonny, Tomas Urbina, Louai Missri, Jean-Luc Baudel, Aurelia Retbi, Victor Penaud, Guillaume Voiriot, Yves Cohen, Nicolas De Prost, Bertrand Guidet, Eric Maury, Hafid Ait-Oufella, Jeremie Joffre
Background Data are scarce regarding epidemiology and management of critically ill patients with lung abscesses. Research question What are the clinical and microbiological characteristics of critically ill patients with lung abscesses, how are they managed in the ICUs, and what are the risk factors of in-ICU mortality? Study Design and Methods Retrospective observational multicenter study, based on
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Artificial Intelligence improves novices’ bronchoscopy performance – a randomized controlled trial in a simulated setting Chest (IF 9.6) Pub Date : 2023-08-23 Kristoffer Mazanti Cold, Sujun Xie, Anne Orholm Nielsen, Paul Frost Clementsen, Lars Konge
Background Navigating through the bronchial tree and visualizing all bronchial segments is the initial step toward learning flexible bronchoscopy. A novel bronchial segment identification system based on artificial intelligence (AI) has been developed to help guide trainees toward more effective training. Research Question Does feedback from an AI-based automatic bronchial segment identification system
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THORACIC APPLICATIONS OF SPECTRAL CT Chest (IF 9.6) Pub Date : 2023-08-22 Jonathan Moore, Jacques Remy, Erica Altschul, Jesse Chusid, Thomas Flohr, Suhail Raoof, Martine Remy-Jardin
Topic importance Thoracic imaging with computed tomography (CT) has become an essential component in the evaluation of respiratory and thoracic diseases. Providers have historically utilized conventional single energy CT; however, prevalence of dual energy CT (DECT) is increasing and as such it is important for thoracic physicians to recognize the utility and limitations of this technology. Review
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Peripheral administration of norepinephrine: a prospective observational study Chest (IF 9.6) Pub Date : 2023-08-21 Jason R. Yerke, Eduardo Mireles-Cabodevila, Alyssa Y. Chen, Stephanie N. Bass, Anita J. Reddy, Seth R. Bauer, Lynne Kokoczka, Siddharth Dugar, Ajit Moghekar
Background Historically, norepinephrine has been administered through a central venous catheter (CVC) due to concerns about the risk of ischemic tissue injury if extravasation from a peripheral intravenous catheter (PIV) occurs. Recently, several reports have suggested that peripheral administration of norepinephrine may be safe. Research question Can a protocol for peripheral norepinephrine administration
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The Minnesota Medical Operations Coordination Center (MOCC): A COVID-19 statewide response to ensure access to critical care and medical-surgical beds Chest (IF 9.6) Pub Date : 2023-08-17 Karyn D. Baum, Lauren Vlaanderen, Walter James, Mary Jo Huppert, Paul Kettler, Christine Chell, Adam Shadiow, Helen Strike, Kay Greenlee, Daniel Brown, John L. Hick, Jack M. Wolf, Mark B. Fiecas, Erin McLachlan, Judy Seaberg, Sean MacDonnell, Sarah Kesler, Jeffrey R. Dichter
Background COVID-19 led to unprecedented inpatient capacity challenges particularly in Intensive Care Units (ICUs), which spurred development of statewide or regional placement centers for coordinating transfer (load balancing) of adult patients needing intensive care to hospitals with remaining capacity. Research Question Do Medical Operations Coordination Centers (MOCC) augment patient placement
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Impact of systemic sclerosis-associated interstitial lung disease with and without pulmonary hypertension on survival – a large cohort study of the German network for systemic sclerosis Chest (IF 9.6) Pub Date : 2023-08-13 Pia Moinzadeh, Francesco Bonella, Max Oberste, Jithmi Weliwitage, Nobert Blank, Gabriela Riemekasten, Ulf Müller-Ladner, Jörg Henes, Elise Siegert, Claudia Günther, Ina Kötter, Christiane Pfeiffer, Marc Schmalzing, Gabriele Zeidler, Peter Korsten, Laura Susok, Aaron Juche, Margitta Worm, Ilona Jandova, Jan Ehrchen, Michael Kreuter
Background Pulmonary involvement is the leading cause of death in systemic sclerosis (SSc) and may manifest as interstitial lung disease (ILD), pulmonary arterial hypertension (PAH), or in combination of both (ILD-pulmonary hypertension (PH)). Aim of this analysis was to determine prevalence, clinical characteristics, and survival of these different forms within the registry of the German Network for
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Effect of admission and onset time on the prognosis of patients with cardiogenic shock Chest (IF 9.6) Pub Date : 2023-08-12 Michael Behnes, Jonas Rusnak, Sascha Egner-Walter, Marinela Ruka, Jonas Dudda, Alexander Schmitt, Jan Forner, Kambis Mashayekhi, Péter Tajti, Mohamed Ayoub, Christel Weiß, Ibrahim Akin, Tobias Schupp
Background Related to ongoing demographic changes, the spectrum of patients with cardiogenic shock (CS) has significantly changed and more patients develop CS in the absence of acute myocardial infarction (AMI). However, these patients were typically excluded from prior studies. Very limited data regarding the prognostic role of CS onset and hospital admission is available. Research Question Does the
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Risk of SARS-CoV-2 infection and disease severity among people with bronchiectasis; analysis of three population registries. Chest (IF 9.6) Pub Date : 2023-08-11 Michal Shteinberg, Oriol Sibila, Nili Stein, Rosa Faner, Alexander Jordan, Nuria Olvera, Pradeesh Sivapalan, Jens Ulrik S Jensen, Megan Crichton, Pau Marrades, James D. Chalmers, Christian N. Meyer, Walid Saliba
Abstract not available
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Low- Versus Conventional-Dose Trimethoprim-Sulfamethoxazole Treatment for Pneumocystis Pneumonia in Non-Human Immunodeficiency Virus-Infected Patients: A Multi-Center, Retrospective Observational Cohort Study Chest (IF 9.6) Pub Date : 2023-08-11 Tatsuya Nagai, Hiroki Matsui, Haruka Fujioka, Yuya Homma, Ayumu Otsuki, Hiroyuki Ito, Shinichiro Ohmura, Toshiaki Miyamoto, Daisuke Shichi, Watari Tomohisa, Yoshihito Otsuka, Kei Nakashima
Background Trimethoprim-sulfamethoxazole (TMP-SMX) is an effective treatment for Pneumocystis jirovecii pneumonia (PCP) in immunocompromised patients with and without human immunodeficiency virus (HIV) infection; however, a high incidence of adverse events has been observed. Low-dose TMP-SMX is a potentially effective treatment with fewer adverse events; however, evidence is limited. Research question
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Comparative effectiveness of first-line and alternative antibiotic regimens in hospitalized patients with non-severe community acquired pneumonia: A multi-centre retrospective cohort study Chest (IF 9.6) Pub Date : 2023-08-11 Anthony D. Bai, Siddhartha Srivastava, Benjamin KC. Wong, Genevieve C. Digby, Fahad Razak, Amol A. Verma
Background There are several antibiotic regimens to treat community-acquired pneumonia (CAP). Research question In patients hospitalized to a non-ICU ward setting with CAP, is there a difference between first-line and alternative antibiotic regimens (β-lactam plus macrolide (BL+M), β-lactam alone (BL), respiratory fluoroquinolone (FQ) or β-lactam plus doxycycline (BL+D)) in terms of in-hospital mortality
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Interstitial Lung Disease Cases, Prevalence Rates and Trends Among U.S. States Chest (IF 9.6) Pub Date : 2023-08-10 Niranjan Jeganathan, Matheni Sathananthan
Abstract not available
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Association of metabolic syndrome with risk of lung cancer: a population-based prospective cohort study Chest (IF 9.6) Pub Date : 2023-08-10 Mengmeng Li, Su-Mei Cao, Niki Dimou, Lan Wu, Ji-Bin Li, Jun Yang
Background Both the incidence of lung cancer and the prevalence of metabolic syndrome (MetS) have been increasing worldwide. The relationship between MetS and lung cancer remains controversial. Research Question Is the risk of lung cancer associated with MetS and its components? Study Design and Methods Multivariable Cox regression models were used to estimate the hazard ratio (HR) of MetS-related
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Multiplex PCR assay to detect nasopharyngeal viruses in immunocompromised patients with acute respiratory failure. Chest (IF 9.6) Pub Date : 2023-08-09 Alexis Maillard, Jérôme Le Goff, Mariame Barry, Virginie Lemiale, Séverine Mercier-Delarue, Alexandre Demoule, Linda Feghoul, Samir Jaber, Kada Klouche, Achille Kouatchet, Laurent Argaud, Francois Barbier, Naike Bigé, Anne-Sophie Moreau, Emmanuel Canet, Frédéric Pène, Maud Salmona, Djamel Mokart, Elie Azoulay
Background In immunocompromised patients with acute respiratory failure (ARF), the clinical significance of respiratory virus detection in the nasopharynx remains uncertain. Research Question Is viral detection in nasopharyngeal swabs associated with causes and outcomes of ARF in immunocompromised patients? Study Design and Methods Preplanned post hoc analysis of a randomized controlled trial enrolling
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Impact of diabetes on lung cancer screening efficacy in the NLST. Chest (IF 9.6) Pub Date : 2023-08-09 Robert P. Young, Raewyn J. Scott, Ralph C. Ward, Gerard A. Silvestri
Abstract not available
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The SGS-6: A Novel QOL Survey Validated to Predict Need for Intervention in Patients with Idiopathic Subglottic Stenosis Chest (IF 9.6) Pub Date : 2023-08-06 Richard J. Lu, Baraa Hijaz, Matthew R. Naunheim, Lily Stevenson, Ramon A. Franco
Background Idiopathic subglottic stenosis (iSGS) is a recurrent, chronic disease defined by fibro-inflammatory narrowing of the subglottic airway. A key challenge in treatment is monitoring disease progression, which may be debilitating and unpredictable in timing. Research Question Can the SGS-6 Questionnaire be validated as a novel QOL instrument to proactively monitor breathing, disease progression
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Unique Changes in the Incidence of Acute Chest Syndrome in Children with Sickle-Cell Disease Unravel the Role of Respiratory Pathogens: A Time-Series Analysis Chest (IF 9.6) Pub Date : 2023-08-05 Zein Assad, Zaba Valtuille, Alexis Rybak, Florentia Kaguelidou, Andrea Lazzati, Emmanuelle Varon, Luu-Ly Pham, Lea Lenglart, Albert Faye, Marion Caseris, Robert Cohen, Corinne Levy, Astrid Vabret, Francois Gravey, Francois Angoulvant, Berengere Koehl, Naim Ouldali
BACKGROUND Acute chest syndrome (ACS) is a life-threatening complication of sickle-cell disease (SCD). Although respiratory pathogens are frequently detected in children with ACS, their respective role in triggering the disease is still unclear. We hypothesized that ACS incidence followed the unprecedented population-level changes in respiratory pathogens dynamics following the COVID-19-related non-pharmaceutical
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Long-term Survival of American Joint Committee on Cancer 8th Edition Staging Descriptors for Clinical M1a Non-Small-Cell Lung Cancer Chest (IF 9.6) Pub Date : 2023-08-05 Arvind Kumar, Barry Xu, Deepti Srinivasan, Alexandra L. Potter, Vignesh Raman, Michael Lanuti, Chi-Fu Jeffrey Yang, Hugh G. Auchincloss
Background The American Joint Committee on Cancer (AJCC) 8th Edition TNM staging manual for non-small-cell lung cancer (NSCLC) M1a descriptors include tumors presenting with malignant pleural or pericardial effusion (“M1a-Effusion”), pleural or pericardial nodule(s) (“M1a-Pleural”), or separate tumor nodule(s) in a contralateral lobe (“M1a-Contralateral”). Research Question Is M1a NSCLC presenting
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Comparing the Utilization of the Anti-Fibrotic Medications Based on Income Level Chest (IF 9.6) Pub Date : 2023-08-03 Timothy M. Dempsey, Viengneesee Thao, David Helfinstine, Lindsey Sangaralingham, Andrew H. Limper
Abstract not available
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ARITHMETIC BEHIND A POSITIVE BRONCHODILATOR RESPONSE Chest (IF 9.6) Pub Date : 2023-08-03 Philippe Haouzi, Jonathan McCully, Avantika Nathani, Uddalak Majumdar, Kathryn Ickes, Brigita Smith, Joseph Khabbaza
Abstract not available
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Central and peripheral hemodynamics in young waterpipe smokers and the acute effects of waterpipe smoking Chest (IF 9.6) Pub Date : 2023-08-02 Hassan A. Chami, Maya Diab, Nour Zaouk, Samir Arnaout, Gary F. Mitchell, Hussain Isma’eel, Alan Shihadeh
Background Waterpipe tobacco smoking (WPS) is popular among young adults globally and exposes users to toxicants. Research Question Is WPS associated with impaired measures of arterial function and does WPS acutely impair these measures in young adults? Study Design and Methods We assessed heart rate (HR), brachial and aortic blood pressure (BP), HR-adjusted augmentation index (AI), and carotid-femoral
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Integration and application of radiologic patterns from clinical practice guidelines on idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis Chest (IF 9.6) Pub Date : 2023-08-02 Daniel-Costin Marinescu, Cameron J. Hague, Nestor L. Muller, Darra Murphy, Andrew Churg, Joanne L. Wright, Amna Al-Arnawoot, Ana-Maria Bilawich, Patrick Bourgouin, Gerard Cox, Celine Durand, Tracy Elliot, Jennifer Ellis, Jolene H. Fisher, Derek Fladeland, Amanda Grant-Orser, Gillian C. Goobie, Zachary Guenther, Ehsan Haider, Nathan Hambly, Christopher J. Ryerson
Background Clinical practice guidelines separately describe radiologic patterns of usual interstitial pneumonia (UIP) and fibrotic hypersensitivity pneumonitis (fHP), without direction on whether or how to apply these approaches concurrently within a single patient. Research Question How can we integrate guideline-defined radiologic patterns to diagnose interstitial lung disease (ILD) and what are
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Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Invasive Treatment: a post-hoc Bayesian re-analysis of a randomized clinical trial Chest (IF 9.6) Pub Date : 2023-08-02 Daniel Rob, Arnošt Komárek, Jana Šmalcová, Jan Bělohlávek
Abstract not available