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Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline Chest (IF 10.262) Pub Date : 2022-08-11 James D. Douketis, Alex C. Spyropoulos, M. Hassan Murad, Juan I. Arcelus, William E. Dager, Andrew S. Dunn, Ramiz A. Fargo, Jerrold H. Levy, C. Marc Samama, Sahrish H. Shah, Matthew W. Sherwood, Alfonso J. Tafur, Liang V. Tang, Lisa K. Moores
Background The American College of Chest Physicians Clinical Practice Guideline on the Perioperative Management of Antithrombotic Therapy addresses 43 patients-interventions-comparators-outcomes (PICO) questions related to the perioperative management of patients who are receiving long-term oral anticoagulant or antiplatelet therapy and require an elective surgery/procedure. This guideline is separated
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Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline Executive Summary Chest (IF 10.262) Pub Date : 2022-08-11 James D. Douketis, Alex C. Spyropoulos, M. Hassan Murad, Juan I. Arcelus, William E. Dager, Andrew S. Dunn, Ramiz A. Fargo, Jerrold H. Levy, C. Marc Samama, Sahrish H. Shah, Matthew W. Sherwood, Alfonso J. Tafur, Liang V. Tang, Lisa K. Moores
Background The American College of Chest Physicians Clinical Practice Guideline on the Perioperative Management of Antithrombotic Therapy addresses 43 patients-interventions-comparators-outcomes (PICO) questions related to the perioperative management of patients who are receiving long-term oral anticoagulant or antiplatelet therapy and require an elective surgery/procedure. This guideline is separated
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Diaphragmatic thickness and excursion in infants born preterm with bronchopulmonary dysplasia compared to term or near term infants: a prospective observational study Chest (IF 10.262) Pub Date : 2022-08-10 Telford Yeung, Nada Mohsen, Mohab Ghanem, Jenna Ibrahim, Jyotsna Shah, Dilkash Kajal, Prakesh S. Shah, Adel Mohamed
Background Diaphragmatic atrophy associated with mechanical ventilation (MV) is reported in pediatric and adult patients, but a similar association has not been described in preterm infants with bronchopulmonary dysplasia (BPD). Research Question Does BPD impact the diaphragm thickness and excursion in infants born before 32 weeks’ gestation compared to healthy late preterm or term infants? Study Design
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Effectiveness of a long-term home-based exercise training program in patients with COPD following pulmonary rehabilitation: A multi-center randomized controlled trial Chest (IF 10.262) Pub Date : 2022-08-08 Anja Frei, Thomas Radtke, Kaba Dalla Lana, Patrick Brun, Thomas Sigrist, Marc Spielmanns, Swantje Beyer, Thomas F. Riegler, Gilbert Büsching, Sabine Spielmanns, Ramona Kunz, Tamara Cerini, Julia Braun, Yuki Tomonaga, Miquel Serra Burriel, Ashley Polhemus, Milo A. Puhan
Background The majority of patients with COPD fail to maintain exercise training after pulmonary rehabilitation (PR). Research Question Does a 12-months home-based, minimal equipment strength training program following PR has an effect on dyspnea, exercise capacity, and patient-reported outcomes in patients with COPD? Study Design and Methods Parallel arm, multicenter study across four Swiss PR clinics
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COVID: Lessons Learned, Lessons Unlearned, Lessons for the Future Chest (IF 10.262) Pub Date : 2022-08-08 Steven M. Hollenberg, David R. Janz, May Hua, Mark Malesker, Nida Qadir, Bram Rochwerg, Curtis N. Sessler, Geneva Tatem, Todd W. Rice
Abstract not available
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Inhaled nitric oxide versus epoprostenol during acute respiratory failure: an observational target trial emulation Chest (IF 10.262) Pub Date : 2022-08-08 Nicholas A. Bosch, Anica C. Law, Emily A. Vail, Kari R. Gillmeyer, Hayley B. Gershengorn, Hannah Wunsch, Allan J. Walkey
Background Inhaled vasodilators nitric oxide and epoprostenol may be initiated to improve oxygenation in mechanically ventilated patients with severe acute respiratory failure; however, practice patterns and head-to-head comparisons of effectiveness are unclear. Research Question What are the practice patterns and comparative effectiveness for inhaled nitric oxide and epoprostenol in severe acute respiratory
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Shared Decision Making During a Lung Cancer Screening Visit: Is it a Barrier or Does it Bring Value? Chest (IF 10.262) Pub Date : 2022-08-06 Jamie L. Studts, Erin A. Hirsch, Gerard A. Silvestri
Abstract not available
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Bilateral Bronchoscopic Lung Volume Reduction After Surgical Fissure Completion Chest (IF 10.262) Pub Date : 2022-08-05 Majid Shafiq, Emily Polhemus, Ryan Perkins, Victoria Forth, M. Blair Marshall
Although bilateral lung volume reduction surgery has been shown to be safe and effective in carefully selected patients with upper lobe-predominant emphysema and hyperinflation, bronchoscopic lung volume reduction via placement of endobronchial valves is conventionally performed only unilaterally. Furthermore, it is not offered to patients with interlobar collateral ventilation because of the lack
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Air Pollution and the Effectiveness of Positive Airway Pressure Therapy in Individuals with Sleep Apnea: A Retrospective Community-Based Repeated Measures Longitudinal Study Chest (IF 10.262) Pub Date : 2022-08-05 Tetyana Kendzerska, Mieczysław Szyszkowicz, Jonathan Villa Alvarez, Ranjeeta Mallick, Christopher Carlsten, Najib Ayas, Cheryl R. Laratta, Branka Jovic, Juma Orach, Marc Smith Doiron, Robert Dales
Background Ambient air pollution may affect the severity of untreated obstructive sleep apnea (OSA), but it is unknown whether air pollution adversely impacts the effectiveness of positive airway pressure (PAP) therapy. Research Question Do short term changes in outdoor air pollution adversely impact adults with OSA using PAP therapy? Study Design and Methods We conducted a retrospective community-based
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Defibrotide Has a Role in COVID-19 Therapy Chest (IF 10.262) Pub Date : 2022-08-05 Antonio Macciò, Giorgio La Nasa, Sara Oppi, Clelia Madeddu
Abstract not available
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Balancing the Benefits and Harms of Lung Cancer Screening Chest (IF 10.262) Pub Date : 2022-08-05 A. Cole Burks, Jason Long, M. Patricia Rivera
Abstract not available
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Swimming-Induced Pulmonary Edema Chest (IF 10.262) Pub Date : 2022-08-05 Peter Wilmshurst
Abstract not available
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Loss of Heterozygosity for Tuberous Sclerosis Complex and Mammalian Target of Rapamycin Signaling Chest (IF 10.262) Pub Date : 2022-08-05 Marissa O’Callaghan, Cormac McCarthy
Abstract not available
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We Must Keep Our Cool Regarding the Effect of Therapeutic Hypothermia After In-Hospital Cardiac Arrest Chest (IF 10.262) Pub Date : 2022-08-05 Markus B. Skrifvars, Janus C. Jakobsen
Abstract not available
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Spirometry as a Predictor of Cardiometabolic Disease Chest (IF 10.262) Pub Date : 2022-08-05 Tianshi David Wu
Abstract not available
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Implications of the COVID-19 Pandemic for the Well-Being of the ICU Workforce Considerations for the ICU Interprofessional Team Chest (IF 10.262) Pub Date : 2022-08-05 Michelle E. Kho, Julie C. Reid
Abstract not available
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POINT: Does Normothermic Regional Perfusion Violate the Ethical Principles Underlying Organ Procurement? Yes Chest (IF 10.262) Pub Date : 2022-08-05 Matthew DeCamp, Lois Snyder Sulmasy, Joseph J. Fins
Abstract not available
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COUNTERPOINT: Does Normothermic Regional Perfusion Violate the Ethical Principles Underlying Organ Procurement? No Chest (IF 10.262) Pub Date : 2022-08-05 Les James, Brendan Parent, Nader Moazami, Deane E. Smith
Abstract not available
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Rebuttal From Dr DeCamp et al Chest (IF 10.262) Pub Date : 2022-08-05 Matthew DeCamp, Joseph J. Fins, Lois Snyder Sulmasy
Abstract not available
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Rebuttal From Dr James et al Chest (IF 10.262) Pub Date : 2022-08-05 Les James, Brendan Parent, Nader Moazami, Deane E. Smith
Abstract not available
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Smokefree New Zealand 2025 Chest (IF 10.262) Pub Date : 2022-08-05 Adam Edward Lang, Alain Braillon
Abstract not available
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The Vexing Voyage of Vasopressin Chest (IF 10.262) Pub Date : 2022-08-05 Liam Bendicksen, Aaron S. Kesselheim, Benjamin N. Rome
Abstract not available
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A Young Child With Recurrent Pneumonia and Hemoptysis During the COVID-19 Pandemic Chest (IF 10.262) Pub Date : 2022-08-05 Zirun Zhao, Rachel Choe Kim, Felix Tavernier, Rachana Choksi, Trevor Van Brunt, James Earl Davis, Katharine Kevill, Helen Hsieh
Case Presentation In July 2020, a previously healthy 6-year-old boy was evaluated in a pulmonary clinic in New York after two episodes of pneumonia in the previous 3 months. For each episode, the patient presented with cough, fever, and hemoptysis, all of which resolved with antibiotic therapy and supportive care. The patient never experienced dyspnea during these episodes of pneumonia. He was asymptomatic
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A 60-Year-Old Woman With Posterior Mediastinal Tumor Chest (IF 10.262) Pub Date : 2022-08-05 Nobuyasu Wakazono, Arei Mizushima, Yukiko Maeda, Natsuko Taniguchi, Katsura Nagai, Atsuo Hattori, Toshiyuki Harada
Case Presentation A 60-year-old woman, a care worker with no known comorbidities, presented to the pulmonary clinic for assessment of a left hilar tumor detected on chest radiography. She had a history of oophorocystectomy and was a 0.5-pack/day smoker. She was asymptomatic but desired a confirmative diagnosis.
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A 54-Year-Old Man With Migratory Pulmonary Consolidation and Progressive Dyspnea Chest (IF 10.262) Pub Date : 2022-08-05 Juei-Yang Ma, Cheng-Hao Chuang
Case Presentation A 54-year-old man with chronic hepatitis B was admitted to the hospital with progressive dyspnea on exertion. He reported experiencing intermittent fever, dyspnea on exertion, and relapsing pleuritic chest pain starting 6 months prior, after his first dose of the ChAdOx1 nCoV-19 vaccine. In the past 2 months, he had been admitted to the hospital twice and diagnosed with recurrent
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An Adolescent With a Retropharyngeal Swelling: To Drain or Not to Drain? Chest (IF 10.262) Pub Date : 2022-08-05 Sybren Robijn, Stan van Keulen, Godelieve Verhage-Damen, Stijn Bekkers
Case Presentation An 18-year-old patient with a history of COVID-19 (1 month previously) was admitted with malaise and complaints of a stiff neck, a left-sided cervical mass, headache, and difficulty in swallowing and breathing, which had been present for 4 days. Two days after the onset of the first symptoms, a painless skin rash on the legs, arms, palms of both hands, and soles of both feet developed
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An Unusual Source of Tension Chest (IF 10.262) Pub Date : 2022-08-05 Patrick J. Sylvester, Akshay B. Vijayaraman, Carleen R. Spitzer
Case Presentation A 67-year-old man with a history of hypertension, type 2 diabetes, and COPD requiring supplemental oxygen at baseline (4 L by nasal cannula) was admitted to the hospital for progressive dyspnea and dysphagia in the context of a newly diagnosed supraglottic mass.
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Sudden Hemodynamic Instability After Unproning a Patient With COVID-19 Pneumonia Chest (IF 10.262) Pub Date : 2022-08-05 André C.G. Hirano, Livia M.G. Melro, Bruno A.M. P. Besen
Abstract not available
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In Real-World Studies, Comparisons of Predictive Values Are Confounded by Prevalence Chest (IF 10.262) Pub Date : 2022-08-05 Gene Pennello
Abstract not available
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A Nonrigorous and Incorrect Evaluation of the Fast Fit Test Chest (IF 10.262) Pub Date : 2022-08-05 Lisa M. Brosseau, Rachael M. Jones
Abstract not available
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Occupational Exposures in Nontuberculous Mycobacterial Pulmonary Disease Chest (IF 10.262) Pub Date : 2022-08-05 Paul D. Blanc, John R. Balmes, Carrie Redlich
Abstract not available
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Prehospital Management of Swimming-Induced Pulmonary Edema Chest (IF 10.262) Pub Date : 2022-08-05 Paolo Ruggeri, Alastair Glossop, Antonio M. Esquinas
Abstract not available
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Immediate, remote smoking cessation intervention in participants undergoing a targeted lung health check: QuLIT2 a randomised controlled trial. Chest (IF 10.262) Pub Date : 2022-08-04 Parris J. Williams, Keir EJ. Philip, Navjot Kaur Gill, Deirdre Flannery, Sara Buttery, Emily C. Bartlett, Anand Devaraj, Samuel V. Kemp, Jamie Addis, Jane Derbyshire, Michelle Chen, Katie Morris, Anthony A. Laverty, Nicholas S. Hopkinson
Background Lung cancer screening programs provide an opportunity to support people who smoke to quit, but the most appropriate model for delivery remains to be determined. Immediate face to face smoking cessation support for people undergoing screening can increase quit rates, but it is not known whether remote delivery of immediate smoking cessation counselling and pharmacotherapy in this context
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Sex Differences in Outcomes of Percutaneous Pulmonary Artery Thrombectomy in Patients with Pulmonary Embolism Chest (IF 10.262) Pub Date : 2022-08-02 Manyoo A. Agarwal, Jasmeet S. Dhaliwal, Eric H. Yang, Olcay Aksoy, Marcella Press, Karol Watson, Boback Ziaeian, Gregg C. Fonarow, John M. Moriarty, Rajan Saggar, Richard Channick
Background The sex differences in utilization, safety outcomes, and healthcare resource utilization of patients with PE undergoing percutaneous pulmonary artery thrombectomy are not well characterized. Research Question What are the sex differences in outcomes for patients diagnosed with pulmonary embolism (PE) undergoing percutaneous pulmonary artery thrombectomy? Study Design and Methods This retrospective
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Association of Inhaled Corticosteroids With All-cause Death Risk in COPD Patients: A Meta-analysis of Sixty Randomized Controlled Trials Chest (IF 10.262) Pub Date : 2022-07-31 Hong Chen, Zheng-Xu Deng, Jian Sun, Qiang Huang, Lan Huang, Yong-Hong He, Chunlan Ma, Ke Wang
BACKGROUND Inhaled corticosteroids (ICSs) have been widely used in the maintenance therapy of COPD. However, whether inhaled therapy containing ICSs can reduce the all-cause death risk and the possible benefited patient subgroups are unclear. RESEARCH QUESTION Does inhaled therapy containing ICSs reduce the all-cause death risk in COPD patients compared with other inhaled therapy not containing ICSs
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The relationship between norepinephrine equivalent dose of vasopressors within 24 hours from the onset of septic shock and in-hospital mortality Chest (IF 10.262) Pub Date : 2022-07-31 Ryota Sato, Abhijit Duggal, Gretchen L. Sacha, Michael A. Rudoni, Angel Coz Yataco, Ashish K. Khanna, Siddharth Dugar
Abstract not available
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Feasibility of a new lung ultrasound protocol to determine the extent of lung injury in COVID-19 pneumonia Chest (IF 10.262) Pub Date : 2022-07-31 Giovanni Volpicelli, Thomas Fraccalini, Luciano Cardinale, Giuseppe Stranieri, Rouslan Senkeev, Guido Maggiani, Alberto Pacielli, Domenico Basile
Background Lung ultrasound (LUS) is useful to diagnose and assess the severity of pulmonary lesions during CoViD-19 related acute respiratory distress syndrome (CoARDS). A conventional LUS score is proposed to measure the loss of aeration during CoARDS. However, this score was validated during the pre-COVID-19 era in ARDS patients in intensive care and does not consider the differences with CoARDS
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Treatment preference amongst people with cystic fibrosis: the importance of reducing treatment burden Chest (IF 10.262) Pub Date : 2022-07-19 Rory A. Cameron, Daniel Office, Jessie Matthews, Mark Rowley, Janice Abbott, Nicholas J. Simmonds, Jennifer A. Whitty, Siobhán B. Carr
BACKGROUND There is a growing consensus that the perspective of the patient should be considered in the evaluation of novel interventions. RESEARCH QUESTION What treatment outcomes matter to people with cystic fibrosis (CF), and what trade-offs would they make to realise these outcomes? STUDY DESIGN AND METHODS Adults attending a specialist CF centre were invited to complete an online discrete choice
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A Double-blind Randomized Placebo-controlled Phase-3 Trial of Tobramycin Inhalation Solution in Adults with Bronchiectasis with Pseudomonas aeruginosa Infection Chest (IF 10.262) Pub Date : 2022-07-19 Wei-jie Guan, Jin-fu Xu, Hong Luo, Xing-xiang Xu, Yuan-lin Song, Wan-li Ma, Zong-an Liang, Xue-dong Liu, Guo-jun Zhang, Xiao-ju Zhang, Rong-kai Li, Shu-yang Zhu, Yi-jie Zhang, Xing-jun Cai, Li-ping Wei, Dong-bo Tian, Hui Zhao, Ping-yan Chen, Nan-shan Zhong
BACKGROUND Few large-scale studies demonstrated the efficacy of tobramycin nebulization in bronchiectasis. We evaluated the efficacy and safety of nebulized tobramycin inhalation solution (TIS) in adults with bronchiectasis with Pseudomonas aeruginosa infection. RESEARCH QUESTION Can TIS effectively reduce sputum Pseudomonas aeruginosa density and improve the bronchiectasis-specific quality-of-life
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The changing epidemiology of cystic fibrosis: the implications for adult care Chest (IF 10.262) Pub Date : 2022-07-16 Pierre-Régis Burgel, Esperie Burnet, Lucile Regard, Clémence Martin
Cystic fibrosis (CF) is a genetic disease, in which mutations in the gene encoding for the CF transmembrane conductance regulator (CFTR) protein result in a multisystem disease dominated by digestive and respiratory manifestations. In the mid-twentieth century, CF used to cause death within the first years of life. Over the past decades, advances in disease management, including systematic neonatal
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Machine-Learning Model for Mortality Prediction in Patients with Community-acquired Pneumonia: Development and validation study Chest (IF 10.262) Pub Date : 2022-07-16 Catia Cilloniz, Logan Ward, Mads Lause Mogensen, Juan M. Pericàs, Raúl Méndez, Albert Gabarrús, Miquel Ferrer, Carolina Garcia-Vidal, Rosario Menendez, Antoni Torres
Background Artificial intelligence tools and techniques such as machine learning (ML) are increasingly seen as a suitable manner to increase the prediction capacity of currently available clinical tools, including prognostic scores. However, studies evaluating the efficacy of ML methods in enhancing the predictive capacity of existing scores for community-acquired pneumonia (CAP) are limited. We aimed
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Multi-drug resistant and extended spectrum beta-lactamase Gram-negative bacteria in bilateral lung transplant recipients. Incidence, risk factors and in-hospital mortality. Chest (IF 10.262) Pub Date : 2022-07-16 Annalisa Boscolo, Nicolò Sella, Tommaso Pettenuzzo, Alessandro De Cassai, Silvia Crociani, Chiara Schiavolin, Caterina Simoni, Federico Geraldini, Giulia Lorenzoni, Eleonora Faccioli, Francesco Fortarezza, Francesca Lunardi, Chiara Giraudo, Andrea Dell’Amore, Annamaria Cattelan, Fiorella Calabrese, Dario Gregori, Federico Rea, Paolo Navalesi
Background In the last few decades, the incidence of multidrug-resistant and extended spectrum beta-lactamase (MDR/ESBL) Gram-negative (GN) bacteria has progressively increased among lung transplant (LT) recipients. A prompt diagnosis, prevention and management of these pathogens remain the cornerstone for successful organ transplant. Research question What are the incidence of MDR/ESBL GN bacteria
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Drug-Drug Interactions in the Management of Patients with Pulmonary Arterial Hypertension Chest (IF 10.262) Pub Date : 2022-07-14 Sheryl Wu, Heather B. Hoang, Jenny Yang, Demosthenes G. Papamatheakis, David S. Poch, Mona Alotaibi, Sandra Lombardi, Cynthia Rodriguez, Nick H. Kim, Timothy M. Fernandes
The management of pulmonary arterial hypertension (PAH) has become more complex in recent years due to increased pharmacotherapy options and longer patient survival with increasing numbers of comorbidities. As such, there are more opportunities for drug-drug interactions between PAH-targeted medications and medications potentially used to treat comorbid conditions. In this review, we provide an overview
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A Biomarker-Based Approach for the Determination of Sample Adequacy During Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Proof of Concept Study Chest (IF 10.262) Pub Date : 2022-07-13 Tsukasa Ishiwata, Andrew T. Sage, Kosuke Fujino, Nadia Mohammed, Terunaga Inage, Nicholas Bernards, Shaf Keshavjee, Kazuhiro Yasufuku
Abstract not available
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“Ventilatory Strategy to Prevent Atelectasis During Bronchoscopy Under General Anesthesia: A Multicenter Randomized Controlled Trial” (VESPA Trial) Chest (IF 10.262) Pub Date : 2022-07-06 Moiz Salahuddin, Mona Sarkiss, Ala-Eddin S. Sagar, Ioannis Vlahos, Christopher H. Chang, Archan Shah, Bruce F. Sabath, Julie Lin, Juhee Song, Teresa Moon, Peter H. Norman, George A. Eapen, Horiana B. Grosu, David E. Ost, Carlos A. Jimenez, Gouthami Chintalapani, Roberto F. Casal
BACKGROUND Atelectasis negatively influences peripheral bronchoscopy increasing CT-body divergence, obscuring targets, and creating false positive radial-probe endobronchial ultrasound (RP-EBUS) images. RESEARCH QUESTION Can a ventilatory strategy reduce the incidence of atelectasis during bronchoscopy under general anesthesia? STUDY DESIGN AND METHODS: Randomized controlled study (1:1) where patients
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Gratitude for the Year, Excitement for the Future Chest (IF 10.262) Pub Date : 2022-07-06 Peter J. Mazzone
Abstract not available
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Are We Poised to Change the Trajectory of Maintenance Oral Corticosteroid Use in Severe Asthma in the Age of Biologics? Chest (IF 10.262) Pub Date : 2022-07-06 Njira Lugogo, Arjun Mohan
Abstract not available
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Tough Decisions in Resuscitation Chest (IF 10.262) Pub Date : 2022-07-06 Gerard Bury
Abstract not available
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Facilitating Adherence to Annual Screening for Lung Cancer Chest (IF 10.262) Pub Date : 2022-07-06 Lori C. Sakoda, Michael K. Gould
Abstract not available
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The Challenges of Using Race- and Ethnicity-Based Spirometry Reference Equations in Genetically Admixed Populations Chest (IF 10.262) Pub Date : 2022-07-06 Michele Arigliani, Sanja Stanojevic
Abstract not available