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A meta-analysis of persuasive design, engagement, and efficacy in 92 RCTs of mental health apps npj Digit. Med. (IF 12.4) Pub Date : 2025-04-29 Lee Valentine, Jordan D. X. Hinton, Kriti Bajaj, Larissa Boyd, Shaunagh O’Sullivan, Rory P. Sorenson, Imogen H. Bell, Miguel Sobredo Vega, Ping Liu, Wilma Peters, Shaminka N. Mangelsdorf, Thomas W. Wren, Carl Moller, Shane Cross, Carla McEnery, Sarah Bendall, Jennifer Nicholas, Mario Alvarez-Jimenez
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A highly mobile adeno-associated virus targeting vascular smooth muscle cells for the treatment of pulmonary arterial hypertension Nat. Biomed. Eng. (IF 26.8) Pub Date : 2025-04-29 Yoojin Kim, Yeongju Yeo, Minju Kim, Yong-Wook Son, Joowon Kim, Koung Li Kim, Seohee Kim, Seokmin Oh, Yunha Kim, Hyowoo Lee, Hyun-Woo Park, Dongsoo Lee, Sung Jin Lee, Changmin Kang, Hongyoung Choi, Chan Soon Park, Seung-Pyo Lee, Wonhee Suh, Jae-Hyung Jang
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The Severity of Pollen‐Induced Allergic Rhinitis at 16 Years of Age: Data From the Population‐Based BAMSE Birth Cohort Allergy (IF 12.6) Pub Date : 2025-04-29 Magnus Lindqvist, Marit Westman, Allan Linneberg, Inger Kull, Anna Bergström, Marianne van Hage, Erik Melén, Katja Biering Leth‐Møller
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Artificial intelligence based multispecialty mortality prediction models for septic shock in a multicenter retrospective study npj Digit. Med. (IF 12.4) Pub Date : 2025-04-28 Shurui Wang, Xinyi Liu, Shaohua Yuan, Yi Bian, Hong Wu, Qing Ye
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You are what you eat: metabolic recycling of phagocytosed bacteria modulates macrophage immunity Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-28 Syamantak Basu, Manuela Rossol
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N-deglycosylation targeting chimera (DGlyTAC): a strategy for immune checkpoint proteins inactivation by specifically removing N-glycan Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-28 Li Li, Jiajia Wu, Weiqian Cao, Wei Zhang, Qi Wu, Yaxu Li, Yanrong Yang, Zezhi Shan, Zening Zheng, Xin Ge, Liang Lin, Ping Wang
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Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-28 Chen Wei, Kun Liao, Hao-Jie Chen, Zi-Xuan Xiao, Qi Meng, Ze-Kun Liu, Yun-Xin Lu, Hui Sheng, Hai-Yu Mo, Qi-Nian Wu, Yi Han, Zhao-Lei Zeng, Xin-Yuan Guan, Hui-Yan Luo, Huai-Qiang Ju, Rui-Hua Xu
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High-precision information retrieval for rapid clinical guideline updates npj Digit. Med. (IF 12.4) Pub Date : 2025-04-27 Florian Borchert, Paul Wullenweber, Annika Oeser, Nina Kreuzberger, Torsten Karge, Thomas Langer, Nicole Skoetz, Lothar H. Wieler, Matthieu-P. Schapranow, Bert Arnrich
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Dual stream transformer for medication state classification in Parkinson’s disease patients using facial videos npj Digit. Med. (IF 12.4) Pub Date : 2025-04-26 Vasileios Skaramagkas, Iro Boura, Georgios Karamanis, Ioannis Kyprakis, Dimitrios I. Fotiadis, Zinovia Kefalopoulou, Cleanthe Spanaki, Manolis Tsiknakis
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In vivo immunogenicity assessment of a multiepitope‐displayed phage vaccine against Brucella species infection in BALB/c mice Bioeng. Transl. Med. (IF 6.1) Pub Date : 2025-04-26 Mahmood Fadaie, Mahsa Esmaeilifallah, Anis Khalafiyan, Ilnaz Rahimmanesh, Seyed Hossein Hejazi, Hossein Khanahmad
Bacteriophages are considered ideal vaccine platforms owing to their safety, intrinsic adjuvant properties, stability, and low‐cost production. One of the best strategies to prevent brucellosis in humans and animals is vaccination. For several years, researchers have dedicated their efforts to enhance the effectiveness and safety of the Brucella vaccine. This study was designed to evaluate the immunogenicity
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Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-25 Juan Guo, Xueting Pan, Qingyuan Wu, Ping Li, Chaohui Wang, Shuang Liu, Haoyuan Zhang, Zezhong Huang, Xiaozhou Mou, Huiyu Liu, Jiajia Xue
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Diabetic neuropathy: cutting-edge research and future directions Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-25 Yang Yang, Bing Zhao, Yuanzhe Wang, Hongli Lan, Xinyu Liu, Yue Hu, Peng Cao
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A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-25 Hanwen Li, Yongyao Wu, Lisha Xiang, Qing Zhao, Lu Liu, Zhixiong Zhu, Weimin Lin, Zhan Li, Yang Yang, Yiting Ze, Lulu Zhang, Ping Fu, Yingqiang Guo, Ping Zhang, Bin Shao
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STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-25 Xiaohong Wang, Tao Chen, Sizhe Chen, Jie Zhang, Liangyu Cai, Changhao Liu, Yujie Zhang, Xiao Wu, Na Li, Zhiyong Ma, Lei Cao, Qian Li, Chenghu Guo, Qiming Deng, Wenqian Qi, Yonghao Hou, Ruiqing Ren, Wenhai Sui, Haonan Zheng, Yun Zhang, Meng Zhang, Cheng Zhang
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Machine learning-based forecasting of daily acute ischemic stroke admissions using weather data npj Digit. Med. (IF 12.4) Pub Date : 2025-04-25 Nandhini Santhanam, Hee E. Kim, David Rügamer, Andreas Bender, Stefan Muthers, Chang Gyu Cho, Angelika Alonso, Kristina Szabo, Franz-Simon Centner, Holger Wenz, Thomas Ganslandt, Michael Platten, Christoph Groden, Michael Neumaier, Fabian Siegel, Máté E. Maros
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Conformal prediction enables disease course prediction and allows individualized diagnostic uncertainty in multiple sclerosis npj Digit. Med. (IF 12.4) Pub Date : 2025-04-24 Akshai Parakkal Sreenivasan, Aina Vaivade, Yassine Noui, Payam Emami Khoonsari, Joachim Burman, Ola Spjuth, Kim Kultima
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Bionic scaffolds with integrated structural components based on low‐temperature deposition manufacturing 3D printing technology for the treatment of meniscus defects Bioeng. Transl. Med. (IF 6.1) Pub Date : 2025-04-25 Shi Shen, Yujie Li, Mingxue Chen, Weimin Guo, Shuang Gao, Zengzeng Zhang, Naiqiang Zhuo, Shuyun Liu, Quanyi Guo
Tissue engineering provides a promising avenue for treating meniscus defects. In this study, a novel polycaprolactone (PCL)/collagen type I (COL I) meniscus scaffold was fabricated using low temperature deposition manufacturing (LDM) 3D printing technology. The scaffold had a ring and radial fiber structure, and its composition and structure were double bionic of the natural meniscus. In vitro experiments
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Opportunities and risks of artificial intelligence in patient portal messaging in primary care npj Digit. Med. (IF 12.4) Pub Date : 2025-04-24 Joshua M. Biro, Jessica L. Handley, J. Malcolm McCurry, Adam Visconti, Jeffrey Weinfeld, J. Gregory Trafton, Raj M. Ratwani
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Evaluating compliance with HeatSuite for monitoring in situ physiological and perceptual responses and personal environmental exposure npj Digit. Med. (IF 12.4) Pub Date : 2025-04-24 Nicholas Ravanelli, KarLee Lefebvre, Adèle Mornas, Daniel Gagnon
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Global Initiative on AI for Health (GI-AI4H): strategic priorities advancing governance across the United Nations npj Digit. Med. (IF 12.4) Pub Date : 2025-04-23 Vijaytha Muralidharan, Madelena Y. Ng, Shada AlSalamah, Sameer Pujari, Kanika Kalra, Rajeshwari Singh, Denise Schalet, Tobi Olantuji, Rohit Malpani, Rubeta N. Matin, Jesutofunmi A. Omiye, Yu Zhao, Anita Sands, Andreas Reis, Jose Eduardo Diaz Mendoza, Tina Hernandez-Boussard, Roxana Daneshjou, Alain B. Labrique
The Global Initiative on Artificial Intelligence for Health (GI-AI4H), established by the World Health Organization, serves to harmonize governance standards for artificial intelligence (AI). The GI-AI4H spearheads novel on-the-ground efforts, especially in low- and middle-income countries, to advance ethical, regulatory, implementation, and operational dimensions of global governance for health AI
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Predictive modeling of hemodynamics during viscerosensory neurostimulation via neural computation mechanism in the brainstem npj Digit. Med. (IF 12.4) Pub Date : 2025-04-23 Jiho Lee, Junseung Mun, Minhye Choo, Sung-Min Park
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Understanding contraceptive switching rationales from real world clinical notes using large language models npj Digit. Med. (IF 12.4) Pub Date : 2025-04-23 Brenda Y. Miao, Christopher Y. K. Williams, Ebenezer Chinedu-Eneh, Travis Zack, Emily Alsentzer, Atul J. Butte, Irene Y. Chen
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Fish Allergenicity Ladder and Parvalbumin Epitopes for Predicting Clinical Cross‐Reactivity and Reintroduction in Chinese Population Allergy (IF 12.6) Pub Date : 2025-04-24 Christine Y. Y. Wai, Nicki Y. H. Leung, Agnes S. Y. Leung, Man Fung Tang, Åsa Marknell DeWitt, Jaime S. Rosa Duque, Gilbert T. Chua, Yat Sun Yau, Wai Hung Chan, Po Ki Ho, Mike Y. W. Kwan, Qun Ui Lee, Joshua S. C. Wong, Ivan C. S. Lam, James W. C. H. Cheng, David C. K. Luk, Zhongyi Liu, Noelle Anne Ngai, Oi Man Chan, Patrick S. C. Leung, Gary W. K. Wong, Ting Fan Leung
BackgroundIgE‐mediated fish allergy has long been considered an umbrella term due to the high cross‐reactivity of parvalbumin, the major fish allergen. Yet, clinical tolerance to certain fish highlights allergenicity differences. In this study, we sought to construct a fish allergenicity ladder and identify fish parvalbumin epitopes to improve the diagnosis of fish allergy.MethodsReported clinical
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Oral Immunotherapy in Peanut‐Allergic Adults Using Real‐World Materials Allergy (IF 12.6) Pub Date : 2025-04-24 Hannah Hunter, Kok Loong Ue, Victoria Cornelius, Ching Ching Yung, Iason Thomas, Olympia Tsilochristou, Janice Layhadi, Leonard Q. C. Siew, Carina Venter, Mohamed H. Shamji, Stephen J. Till
BackgroundPeanut oral immunotherapy (OIT) has shown effectiveness in achieving desensitization of children; however, evidence in adults is lacking.MethodsThis phase II trial evaluated peanut OIT in peanut‐allergic adults using real‐world peanut products. A Simon's minimax two‐stage design, incorporating a stop:go for futility, was employed. A separate untreated control group was also recruited for
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Age sensitive response of systemic AAV-mediated gene therapy in a newly characterized feline model of mucolipidosis II. Mol. Ther. (IF 12.1) Pub Date : 2025-04-24 Nettie K Pyne,Jessica Bagel,Charles Shyng,Patricia Odonnell,Keiko Miyadera,Jennifer Srnak,Gary Swain,Jill P Pesayco,G Diane Shelton,Charles-Antoine Assenmacher,Patricia Dickson,Joshua Stern,Heather Flanagan-Steet,Steven J Gray,Allison M Bradbury
Mucolipidosis II (MLII) is a lysosomal storage disorder caused by mutations in GNPTAB and loss of mannose 6-phosphate-dependent targeting of lysosomal enzymes. Affected children exhibit cognitive deficits, skeletal dysplasia and cardio-pulmonary disease with death typically occurring before ten. A naturally occurring feline model of MLII results from a nonsense mutation in GNPTAB; cats develop elevated
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A novel tolerogenic antigen-specific vaccine induces VISTA-enriched regulatory T cells and protects against arthritis in DRB1*04:01 mice. Mol. Ther. (IF 12.1) Pub Date : 2025-04-24 Laura Romero-Castillo,Rajan Kumar Pandey,Bingze Xu,Christian M Beusch,Ana Oliveira-Coelho,Kejsi Zeqiraj,Carolin Svensson,Zhongwei Xu,Huqiao Luo,Outi Sareila,Pierre Sabatier,Changrong Ge,Lei Cheng,Vilma Urbonaviciute,Alexander Krämer,Cecilia Lindgren,Sabrina Haag,Johan Viljanen,Roman A Zubarev,Jan Kihlberg,Anna Linusson,Harald Burkhardt,Rikard Holmdahl
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, cartilage damage and bone erosion. Despite improvements with the introduction of biological disease-modifying anti-rheumatic drugs (DMARDs), RA remains an incurable life-lasting disease. Advancements in peptide-based vaccination may open new avenues for treating autoimmune diseases, including RA, by inducing
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Clinical Hematopoietic Stem Cell-Based Gene Therapy. Mol. Ther. (IF 12.1) Pub Date : 2025-04-24 Tami John,Agnieszka Czechowicz
Hematopoietic stem cell (HSC)-based gene therapies have seen extraordinary progress since their initial conception, now fundamentally transforming the treatment paradigms for various inherited hematologic, immunologic and metabolic conditions - with additional use cases under exploration. Decades worth of work with advances in viral vector technologies and cell manufacturing have paved the way for
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Structure-guided engineering of CD112 receptor variants for optimized immunotherapy. Mol. Ther. (IF 12.1) Pub Date : 2025-04-24 Srishti Singh,Estefania Julia,Parismita Kalita,Charlotte Mason,Qianqian Ming,Ansar Lee-Sam,Sumai Gordon,Maria Emilia Buitrago,Daisy W Leung,Patrick Hwu,Vincent C Luca
The immune checkpoint protein, CD112 receptor (CD112R, also known as PVRIG), suppresses T and NK cell activation upon binding to tumor-expressed CD112 (Nectin-2) ligands. Here, we determine the structure of the CD112-CD112R complex and use it to guide the engineering of multiple CD112-targeting immunotherapy candidates. The 2.2 Å-resolution crystal structure reveals an antiparallel, lock-and-key binding
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ErbB2/HER2-targeted CAR-NK cells eliminate breast cancer cells in an organoid model that recapitulates tumor progression. Mol. Ther. (IF 12.1) Pub Date : 2025-04-24 Jasmin Röder,Tijna Alekseeva,Anne Kiefer,Ines Kühnel,Maren Prüfer,Congcong Zhang,Malena Bodden,Sebastian Rosigkeit,Anja Waldmann,Torsten Tonn,Ernesto Bockamp,Stefan Stein,Winfried S Wels
Chimeric antigen receptor-engineered NK cells hold promise for adoptive cancer immunotherapy. In one such approach, the ErbB2 (HER2)-specific CAR-NK cell line NK-92/5.28.z is under investigation as an off-the-shelf therapy in a phase I trial in glioblastoma patients. To evaluate activity of NK-92/5.28.z cells against ErbB2-positive breast cancer, here we developed an organoid model derived from CKP
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IL2-independent expansion, persistence, and antitumor activity in TIL expressing regulatable membrane-bound IL15. Mol. Ther. (IF 12.1) Pub Date : 2025-04-24 Rachel A Burga,Bulent Arman Aksoy,Zheng Ao,Jeremy H Tchaicha,Dhruv K Sethi,Alonso Villasmil Ocando,Gauri S Kulkarni,Scott Lajoie,Kyle D Pedro,Jack Ryan Tremblay,Meghan Langley,Benjamin Primack,Violet A Young,Theresa Ross,Mithun Khattar,Dexue Sun,Dan Jun Li,Shyam Subramanian,Michelle Ols,Jan Ter Meulen
Adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) has demonstrated great potential for patients with treatment-refractory metastatic melanoma. However, the need for interleukin 2 (IL2) co-administration during TIL cell therapy limits patient eligibility and restricts treatment to intensive care units due to the risk of severe side effects. Instead, engineering TIL with membrane-bound
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Response: Promise and open questions of optogenetic vision restoration by MCO. Mol. Ther. (IF 12.1) Pub Date : 2025-04-24 Samarendra K Mohanty,Santosh Mahapatra,Subrata Batabyal,Michael Carlson,Gayatri Kanungo,Ananta Ayyagari,Kissaou Tchedre,Joel A Franco,Michael Singer,Samuel Barone,Sai Chavala,Vinit B Mahajan
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Perspectives and open questions in vision restoration with vMCO-010. Mol. Ther. (IF 12.1) Pub Date : 2025-04-24 Moritz Lindner
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Tumor immunology: a short IL18 cleavage product promotes cancer immunosurveillance Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-23 Emma Guilbaud, Lorenzo Galluzzi
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Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-23 Jia He, Haibo Yu, Kunling Song, Ailong Huang, Yongjun Dang, Juan Chen, Zufeng Guo
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Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-23 Xinzhong Liao, Qian Xie, Minqi Liang, Qijun Liao, Bi Huang, Shengze Zhang, Feng Zhang, Liangliang Wang, Lifang Yuan, Xuejie Liu, Simin Wen, Chuming Luo, Dayan Wang, Yongkun Chen, Huanle Luo, Yuelong Shu
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A scoping review on the role of virtual walking intervention in enhancing wellness npj Digit. Med. (IF 12.4) Pub Date : 2025-04-23 Yushen Dai, Jiaying Li, Yan Li, Frances Kam Yuet Wong, Mengqi Li, Chen Li, Ye Jia, Yueying Wang, Janelle Yorke
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Discovery and preclinical development of a potent epigenic editor targeting PCSK9 to lower LDL cholesterol. Mol. Ther. (IF 12.1) Pub Date : 2025-04-22 Qiang Xiong,Frederic Tremblay,Jennifer Marlowe
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IL-27: overclocking cytotoxic T lymphocytes to boost cancer immunotherapy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-21 Silvia Dusi, Vincenzo Bronte, Francesco De Sanctis
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Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-21 Hongling Zhao, Shanshan Gao, Yang Han, Dafei Xie, Lihui Xuan, Xin Huang, Jinhua Luo, Qian Ran, Gang Li, Hejiang Guo, Weixiang Hu, Jin Jia, Xiaochang Liu, Yuhao Liu, Jinpeng Tan, Chenjun Bai, Yongqing Gu, Teng Ma, Zhongjun Li, Hua Guan, Ruixue Huang, Ping-Kun Zhou
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Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-21 Ghazl Al Hamwi, Mohamad Wessam Alnouri, Sven Verdonck, Piotr Leonczak, Shaswati Chaki, Stefan Frischbutter, Pavel Kolkhir, Michaela Matthey, Constantin Kopp, Marek Bednarski, Yvonne K. Riedel, Daniel Marx, Sophie Clemens, Vigneshwaran Namasivayam, Susanne Gattner, Dominik Thimm, Katharina Sylvester, Katharina Wolf, Andreas E. Kremer, Steven De Jonghe, Daniela Wenzel, Magdalena Kotańska, Hydar Ali,
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Consumer insights from a feasibility study on remote and extended use of a novel non-invasive wearable fetal electrocardiogram monitor npj Digit. Med. (IF 12.4) Pub Date : 2025-04-21 Debjyoti Karmakar, Tarini Paul, Emerson Keenan, Marimuthu Palaniswami, Kaitlin Constable, Erica Spessot, Fiona Brownfoot
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Small Molecule Inhibition of SUMOylation Increases Expression from AAV Vectors Both During and After Initial Transduction in Mice. Mol. Ther. (IF 12.1) Pub Date : 2025-04-21 Maria C Seleme,Aradhana Kasimsetty,Young Hwang,Carole Lee,Aoife M Roche,Allysen C Henriksen,John K Everett,Frederic D Bushman,Denise E Sabatino
AAV-based gene therapy has been used to treat thousands of patients, but a limitation can be inefficient transgene expression from AAV vectors. AAV transduction can be affected by the small ubiquitin-like modifier (SUMO) system, in which SUMO proteins are attached to proteins after translation, thereby modulating their function and stability. However, to date, practical modulators of SUMOylation to
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Identification of a robust promoter in mouse and human hepatocytes by in vivo biopanning of a barcoded AAV library. Mol. Ther. (IF 12.1) Pub Date : 2025-04-21 Jonas Becker,Claire Domenger,Pervinder Choksi,Chiara Krämer,Conradin Baumgartl,Olena Maiakovska,Jae-Jun Kim,Jonas Weinmann,Georg Huber,Florian Schmidt,Christian Thirion,Oliver J Müller,Holger Willenbring,Dirk Grimm
Recombinant adeno-associated viruses (AAV) are leading vectors for in vivo human gene therapy. An integral vector element are promoters, which control transgene expression in either a ubiquitous or cell-type-selective manner. Identifying optimal capsid-promoter combinations is challenging, especially when considering on- versus off-target expression. Here, we report a pipeline for in vivo promoter
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Histone deacetylases and their inhibitors in kidney diseases. Mol. Ther. (IF 12.1) Pub Date : 2025-04-21 Yue Zheng,Tie-Ning Zhang,Peng-Hui Hao,Ni Yang,Yue Du
Histone deacetylases (HDACs) have emerged as key regulators in the pathogenesis of various kidney diseases. This review explores recent advancements in HDAC research, focusing on their role in kidney development and their critical involvement in the progression of chronic kidney disease (CKD), acute kidney injury (AKI), autosomal dominant polycystic kidney disease (ADPKD), and diabetic kidney disease
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Clinical Perspective: Advancing hemophilia treatment through gene therapy approaches. Mol. Ther. (IF 12.1) Pub Date : 2025-04-21 Courtney D Thornburg,Steve W Pipe,Alessio Cantore,Carmen Unzu,Micheala Jones,Wolfgang A Miesbach
Hemophilia, a congenital bleeding disorder, can cause arthropathy, impaired mobility, pain, and life-threatening hemorrhage events, significantly impacting quality of life for patients and caregivers. Current therapies, although effective, necessitate costly lifelong treatment, often in specialized settings. However, as a monogenic disorder caused by loss-of-function genetic variants, hemophilia is
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Germany and Europe lead digital innovation and AI with collaborative health data use at continental level npj Digit. Med. (IF 12.4) Pub Date : 2025-04-20 Daniel C. Baumgart, Joseph C. Kvedar
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Advancing perioperative care with digital applications and wearables npj Digit. Med. (IF 12.4) Pub Date : 2025-04-19 Ben Li, Arjun Mahajan, Dylan Powell
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Overcoming barriers in the use of artificial intelligence in point of care ultrasound npj Digit. Med. (IF 12.4) Pub Date : 2025-04-19 Roberto Vega, Masood Dehghan, Arun Nagdev, Brian Buchanan, Jeevesh Kapur, Jacob L. Jaremko, Dornoosh Zonoobi
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Genomic language models could transform medicine but not yet npj Digit. Med. (IF 12.4) Pub Date : 2025-04-18 Micaela Elisa Consens, Ben Li, Anna R. Poetsch, Stephen Gilbert
Recently, a genomic language model (gLM) with 40 billion parameters known as Evo2 has reached the same scale as the most powerful text large language models (LLMs). gLMs have been emerging as powerful tools to decode DNA sequences over the last five years. This article examines the emergence of gLMs and highlights Evo2 as a milestone in genomic language modeling, assessing both the scientific promise
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Circulating Mast Cell Progenitors Are Depleted by Benralizumab in Severe Asthma. Allergy (IF 12.6) Pub Date : 2025-04-19 Michael Fricker,John Harrington,Sarah A Hiles,Peter G Gibson
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Early‐Life Quarantine Increases the Development of Infant Atopic Dermatitis: A Birth Cohort Study in China Allergy (IF 12.6) Pub Date : 2025-04-19 Yi Hu, Jiuru Zhao, Qianwen Shen, Dongjian Yang, Wei Li, Ze Chen, Meng Ni, Baihe Li, Zhenying Lin, Chunyu Cheng, Dongting Yao, Qianqian Zhang, Xiaorui Liu, Hong Li, Xiaoyi Huang, Zheng Tang, Zhiwei Liu
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Asthma Alleviation by Ginsenoside Rb1 via Promotion of Treg Proliferation and Inflammatory T Cell Inhibition Allergy (IF 12.6) Pub Date : 2025-04-19 Susanna Choi, Seung‐Ah Yoo, Kon‐Young Ji, Dong Ho Jung, Saseong Lee, Kang‐Gu Lee, Ki‐Myo Kim, Joo Young Lee, Myung‐A Jung, Bo‐Jeong Pyun, Jung Hur, Joon Young Choi, Chin Kook Rhee, Wan‐Uk Kim, Taesoo Kim
BackgroundRegulatory T cells (Tregs) are living drugs with feasibility, tolerability, and therapeutic benefits. Although Tregs are linked to asthma prognosis through inflammation regulation, no therapeutic agents specifically designed to manage asthma by upregulating Tregs have been developed to date.MethodsWe screened a library of 250 natural products using a cytometric bead array. Among the selected
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Patient‐Reported Outcomes in the Phase III OASIS‐HAE Study of Donidalorsen for Hereditary Angioedema Allergy (IF 12.6) Pub Date : 2025-04-19 Marc A. Riedl, Aaron Yarlas, Laura Bordone, Sabrina Treadwell, Sophie Wang, Kenneth B. Newman, Danny M. Cohn
BackgroundHereditary angioedema (HAE) is a rare disease characterized by unpredictable, frequently severe swelling that negatively impacts patients' quality of life (QoL). In the phase III OASIS‐HAE study (NCT05139810), donidalorsen reduced HAE attack rate, increased disease control, and improved QoL. Here, we report further analysis of donidalorsen's impact on QoL and other patient‐reported outcomes
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Differential DNA Methylation in Peripheral Blood Mononuclear Cells Reflects Asthma Control Status in Adults Allergy (IF 12.6) Pub Date : 2025-04-19 Jin An, Jaehyun Park, Ah. Ra Do, Sujin Seo, Eunsoon Shin, Jong Eun Lee, You Sook Cho, Sungho Won, Tae‐Bum Kim
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Gene-based therapies for steatotic liver disease. Mol. Ther. (IF 12.1) Pub Date : 2025-04-19 Viktoriia Iakovleva,Ype P de Jong
Advances in nucleic acid delivery have positioned the liver as a key target for gene therapy, with adeno-associated virus vectors showing long-term effectiveness in treating hemophilia. Steatotic liver disease (SLD), the most common liver condition globally, primarily results from metabolic dysfunction-associated and alcohol-associated liver diseases. In some individuals, SLD progresses from simple
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GRP94 is Indispensable for Definitive Endoderm Specification of Human Induced Pluripotent Stem Cells. Mol. Ther. (IF 12.1) Pub Date : 2025-04-19 Hua Wei,Christiana Kappler,Erica Green,Hanna Jiang,Tiffany Yeung,Hongjun Wang
Human induced pluripotent stem cell (hiPSC)-derived insulin-producing β cell therapy shows promise in treating type 1 diabetes (T1D) and potentially type 2 diabetes (T2D). Understanding the genetic factors controlling hiPSC differentiation could optimize this therapy. In this study, we investigated the role of glucose-regulated protein 94 (GRP94) in human β cell development by generating HSP90B1/GRP94
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Draining the brain: Gene therapy reverses brain edema in mice with the leukodystrophy MLC. Mol. Ther. (IF 12.1) Pub Date : 2025-04-19 Rogier Min,Niek P van Til,Marjo S van der Knaap
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Environment impacts sexual preference: dopamine sends signals under pressure to decide which sex you like Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-18 Rou Li, Lin Liu, Min Wu
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RNase1-driven ALK-activation is an oncogenic driver and therapeutic target in non-small cell lung cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-18 Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Yaohui Chen, Chenhao Zhou, Lu Li, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L. Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung
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Cancer chemoprevention: signaling pathways and strategic approaches Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-18 Junling Ren, Guangli Yan, Le Yang, Ling Kong, Yu Guan, Hui Sun, Chang Liu, Lei Liu, Ying Han, Xijun Wang