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Shortcut learning in medical AI hinders generalization: method for estimating AI model generalization without external data npj Digit. Med. (IF 15.2) Pub Date : 2024-05-14 Cathy Ong Ly, Balagopal Unnikrishnan, Tony Tadic, Tirth Patel, Joe Duhamel, Sonja Kandel, Yasbanoo Moayedi, Michael Brudno, Andrew Hope, Heather Ross, Chris McIntosh
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FDA-cleared home sleep apnea testing devices npj Digit. Med. (IF 15.2) Pub Date : 2024-05-13 Ji Hyeun Park, Changwon Wang, Hangsik Shin
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Spatial multi-omics at subcellular resolution via high-throughput in situ pairwise sequencing Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-14 Xiaofeng Wu, Weize Xu, Lulu Deng, Yue Li, Zhongchao Wang, Leqiang Sun, Anran Gao, Haoqi Wang, Xiaodan Yang, Chengchao Wu, Yanyan Zou, Keji Yan, Zhixiang Liu, Lingkai Zhang, Guohua Du, Liyao Yang, Da Lin, Junqiu Yue, Ping Wang, Yunyun Han, Zhenfang Fu, Jinxia Dai, Gang Cao
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Safety, immunogenicity and protective effect of sequential vaccination with inactivated and recombinant protein COVID-19 vaccine in the elderly: a prospective longitudinal study Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-13 Hong-Hong Liu, Yunbo Xie, Bao-Peng Yang, Huan-Yue Wen, Peng-Hui Yang, Jin-E Lu, Yan Liu, Xi Chen, Meng-Meng Qu, Yang Zhang, Wei-Guo Hong, Yong-Gang Li, Junliang Fu, Fu-Sheng Wang
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Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-13 Bo Liu, Honghui Liu, Pu Han, Xiaoyun Wang, Chunmei Wang, Xinxin Yan, Wenwen Lei, Ke Xu, Jianjie Zhou, Jianxun Qi, Ruiwen Fan, Guizhen Wu, Wen-xia Tian, George F. Gao, Qihui Wang
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Structural basis of negative regulation of CRISPR-Cas7-11 by TPR-CHAT Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-13 Tian Hong, Qinghua Luo, Haiyun Ma, Xin Wang, Xinqiong Li, Chongrong Shen, Jie Pang, Yan Wang, Yuejia Chen, Changbin Zhang, Zhaoming Su, Haohao Dong, Xiaodi Tang
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Single‐cell profiling highlight pathogenic myeloid features in house dust mite‐induced murine model of airway inflammation Allergy (IF 12.4) Pub Date : 2024-05-13 Jiachen Liu, Jiaoyan Lv, Sijie Chen, Jie Ma, Jiaying Yao, Zan Yuan, Chunyuan Yang, Xiao Li, Xuegong Zhang, Yunping Zhu, Jianhong Zhang, Li Wu
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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-11 Hye Jin Shin, Wooseong Lee, Keun Bon Ku, Gun Young Yoon, Hyun-Woo Moon, Chonsaeng Kim, Mi-Hwa Kim, Yoon-Sun Yi, Sangmi Jun, Bum-Tae Kim, Jong-Won Oh, Aleem Siddiqui, Seong-Jun Kim
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Anaphylaxis in outpatients: A 5‐year retrospective study on incidence and clinical characteristics at a university hospital in Wuhan, China Allergy (IF 12.4) Pub Date : 2024-05-11 Le Li, Hao Chen, Nan Huang, Wenjing Li, Yaqi Yang, Dongxia Ma, Pascal Demoly, Rongfei Zhu
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Proteomics and metabolomics of sputum reveal the potential impact of allergic rhinitis on asthma Allergy (IF 12.4) Pub Date : 2024-05-11 Yujuan Yang, Limei Cui, Pengyi Yu, Jing Guo, Jianwei Wang, Hanrui Wang, Zheying Song, Zhaoxue Zhai, Tong Li, Guangkuo Wang, Yu Yuemei Sun, Yu Zhang, Xicheng Song
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Effect of plateletcrit and methylenetetrahydrofolate reductase (MTHFR) C677T genotypes on folic acid efficacy in stroke prevention Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-10 Yuncong Shi, Zhengzhipeng Zhang, Binyan Wang, Yu Wang, Xiangyi Kong, Yong Sun, Aimin Li, Yimin Cui, Yan Zhang, Jianping Li, Yong Huo, Hui Huang
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Generalized sleep decoding with basal ganglia signals in multiple movement disorders npj Digit. Med. (IF 15.2) Pub Date : 2024-05-10 Zixiao Yin, Huiling Yu, Tianshuo Yuan, Clay Smyth, Md Fahim Anjum, Guanyu Zhu, Ruoyu Ma, Yichen Xu, Qi An, Yifei Gan, Timon Merk, Guofan Qin, Hutao Xie, Ning Zhang, Chunxue Wang, Yin Jiang, Fangang Meng, Anchao Yang, Wolf-Julian Neumann, Philip Starr, Simon Little, Luming Li, Jianguo Zhang
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The application of machine learning techniques in posttraumatic stress disorder: a systematic review and meta-analysis npj Digit. Med. (IF 15.2) Pub Date : 2024-05-09 Jing Wang, Hui Ouyang, Runda Jiao, Suhui Cheng, Haiyan Zhang, Zhilei Shang, Yanpu Jia, Wenjie Yan, Lili Wu, Weizhi Liu
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Distribution shift detection for the postmarket surveillance of medical AI algorithms: a retrospective simulation study npj Digit. Med. (IF 15.2) Pub Date : 2024-05-09 Lisa M. Koch, Christian F. Baumgartner, Philipp Berens
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Imaging bioluminescence by detecting localized haemodynamic contrast from photosensitized vasculature Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-10 Robert Ohlendorf, Nan Li, Valerie Doan Phi Van, Miriam Schwalm, Yuting Ke, Miranda Dawson, Ying Jiang, Sayani Das, Brenna Stallings, Wen Ting Zheng, Alan Jasanoff
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Meteorin‐like protein/METRNL/Interleukin‐41 ameliorates atopic dermatitis‐like inflammation Allergy (IF 12.4) Pub Date : 2024-05-10 Danqi Huang, Xiuting Liu, Xun Gao, Chun Kit Choi, Giovanni Giglio, Luay Farah, Ting‐Fan Leung, Katie Ching‐Yau Wong, Lea Ling‐Yu Kan, Jeffrey Wing‐Heung Chong, Qing‐Jun Meng, Jinyue Liao, Phyllis Fung‐Yi Cheung, Chun‐Kwok Wong
BackgroundMeteorin‐like protein (METRNL)/Interleukin‐41 (IL‐41) is a novel immune‐secreted cytokine/myokine involved in several inflammatory diseases. However, how METRNL exerts its regulatory properties on skin inflammation remains elusive. This study aims to elucidate the functionality and regulatory mechanism of METRNL in atopic dermatitis (AD).MethodsMETRNL levels were determined in skin and serum
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Comparison of upper and lower airway expression of SARS‐COV‐2 receptors in allergic asthma Allergy (IF 12.4) Pub Date : 2024-05-10 Maral Ranjbar, Christiane E. Whetstone, Ruth P. Cusack, Dhuha Al‐Sajee, Hafsa Omer, Nadia Alsaji, Terence Ho, MyLinh Duong, Patrick Mitchell, Imran Satia, Paul K. Keith, Yanqing Xie, Jonathan MacLean, Doron D. Sommer, Paul M. O'Byrne, Roma Sehmi, Gail M. Gauvreau
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Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-05-10 Molly K. Grun, Praveen Honhar, Yazhe Wang, Samantha Rossano, Minsoo Khang, Hee Won Suh, Krista Fowles, Harvey J. Kliman, Alessandra Cavaliere, Richard E. Carson, Bernadette Marquez‐Nostra, W. Mark Saltzman
Long‐lasting vaginal dosage forms could improve the therapeutic efficacy of vaginal microbicides, but achieving long‐term delivery to the vaginal canal has been a significant challenge. To advance understanding of vaginal dosage retention and biodistribution, we describe a method of noninvasive imaging with 89Zr‐labeled bioadhesive nanoparticles (BNPs) in non‐human primates. We additionally examined
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Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-09 Xun Wang, Shujun Jiang, Wentai Ma, Yanliang Zhang, Pengfei Wang
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Longitudinal peanut and Ara h 2 specific‐IgE, ‐IgG4, and ‐IgG4/‐IgE ratios are associated with the natural resolution of peanut allergy in childhood Allergy (IF 12.4) Pub Date : 2024-05-09 Kayla M. Parker, Thanh D. Dang, Rushani Wijesuriya, Victoria X. Soriano, Adrian J. Lowe, Shyamali C. Dharmage, Paxton Loke, Mimi L. K. Tang, Katie J. Allen, Jennifer J. Koplin, Kirsten P. Perrett, Rachel L. Peters
BackgroundThere are no studies of longitudinal immunoglobulin measurements in a population‐based cohort alongside challenge‐confirmed peanut allergy outcomes. Little is known about biomarkers for identifying naturally resolving peanut allergy during childhood.ObjectivesTo measure longitudinal trends in whole peanut and component Ara h 2 sIgE and sIgG4 in the first 10 years of life, in a population
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Unveiling the culprit: the fusobacterium lineage that populates colorectal cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-08 Johannes Betge, Matthias P. Ebert
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A pathological joint–liver axis mediated by matrikine-activated CD4+ T cells Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-08 Junzhi Yi, Hui Zhang, Fangyuan Bao, Zhichu Chen, Yuliang Zhong, Tianning Ye, Xuri Chen, Jingyi Qian, Mengya Tian, Min Zhu, Zhi Peng, Zongyou Pan, Jianyou Li, Zihao Hu, Weiliang Shen, Jiaqi Xu, Xianzhu Zhang, Youzhi Cai, Mengjie Wu, Hua Liu, Jing Zhou, Hongwei Ouyang
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Charting a new course in healthcare: early-stage AI algorithm registration to enhance trust and transparency npj Digit. Med. (IF 15.2) Pub Date : 2024-05-08 Michel E. van Genderen, Davy van de Sande, Lotty Hooft, Andreas Alois Reis, Alexander D. Cornet, Jacobien H. F. Oosterhoff, Björn J. P. van der Ster, Joost Huiskens, Reggie Townsend, Jasper van Bommel, Diederik Gommers, Jeroen van den Hoven
AI holds the potential to transform healthcare, promising improvements in patient care. Yet, realizing this potential is hampered by over-reliance on limited datasets and a lack of transparency in validation processes. To overcome these obstacles, we advocate the creation of a detailed registry for AI algorithms. This registry would document the development, training, and validation of AI models, ensuring
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Online cognitive monitoring technology for people with Parkinson’s disease and REM sleep behavioural disorder npj Digit. Med. (IF 15.2) Pub Date : 2024-05-07 Maria Bălăeţ, Falah Alhajraf, Tanja Zerenner, Jessica Welch, Jamil Razzaque, Christine Lo, Valentina Giunchiglia, William Trender, Annalaura Lerede, Peter J. Hellyer, Sanjay G. Manohar, Paresh Malhotra, Michele Hu, Adam Hampshire
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Importance of SREBP signaling in controlling lipid metabolism and homeostasis in B cells for future vaccine design Allergy (IF 12.4) Pub Date : 2024-05-08 Zsófia Unger, Alina Kuklinski, Cristina Gomez‐Casado
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Therapeutic potential and impact of nanoengineered patient‐derived mesenchymal stem cells in a murine resection and recurrence model of human glioblastoma Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-05-08 Rawan Al‐Kharboosh, Alex Bechtle, Stephany Y. Tzeng, Jiaying Zheng, Sujan Kumar Mondal, David R. Wilson, Carlos Perez‐Vega, Jordan J. Green, Alfredo Quiñones‐Hinojosa
Confounding results of engineered mesenchymal stem cells (MSCs) used as cellular vehicles has plagued technologies whereby success or failure of novel approaches may be dismissed or inaccurately ascribed solely to the biotechnology platform rather than suitability of the human donor. Polymeric materials were screened for non‐viral engineering of MSCs from multiple human donors to deliver bone morphogenic
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CAR-T overdrive: harnessing inosine for metabolic rewiring and stemness induction Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-07 Martí Farrera-Sal, Michael Schmueck-Henneresse
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Dietary selection of commensal protists: expanding host immunity by impacting trans-kindom competition with bacteria Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-06 Bo Li, Min Wu, Huaqiong Li
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Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia: a multicenter, randomized, open-label, phase 3 trial Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-06 Biqi Zhou, Jia Chen, Tianhui Liu, Yishan Ye, Yanming Zhang, Yiyang Ding, Hong Liu, MingQing Zhu, Xiao Ma, Xiaoli Li, Longfei Zhao, Zhihong Lin, He Huang, Yang Xu, Depei Wu
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Multimodal data fusion using sparse canonical correlation analysis and cooperative learning: a COVID-19 cohort study npj Digit. Med. (IF 15.2) Pub Date : 2024-05-07 Ahmet Gorkem Er, Daisy Yi Ding, Berrin Er, Mertcan Uzun, Mehmet Cakmak, Christoph Sadee, Gamze Durhan, Mustafa Nasuh Ozmen, Mine Durusu Tanriover, Arzu Topeli, Yesim Aydin Son, Robert Tibshirani, Serhat Unal, Olivier Gevaert
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Exploring cognitive reserve’s influence: unveiling the dynamics of digital telerehabilitation in Parkinson’s Disease Resilience npj Digit. Med. (IF 15.2) Pub Date : 2024-05-06 Sara Isernia, Sonia Di Tella, Federica Rossetto, Francesca Borgnis, Olivia Realdon, Monia Cabinio, Chiara Pagliari, Alessandro Torchio, Anna Castagna, Valeria Blasi, Maria Caterina Silveri, Francesca Baglio
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Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-07 Di Yin, Yiye Zhong, Sikai Ling, Sicong Lu, Xiaoyuan Wang, Zhuofan Jiang, Jie Wang, Yao Dai, Xiaolong Tian, Qijing Huang, Xingbo Wang, Junsong Chen, Ziying Li, Yang Li, Zhijue Xu, Hewei Jiang, Yuqing Wu, Yi Shi, Quanjun Wang, Jianjiang Xu, Wei Hong, Heng Xue, Hang Yang, Yan Zhang, Lintai Da, Ze-guang Han, Sheng-ce Tao, Ruijiao Dong, Tianlei Ying, Jiaxu Hong, Yujia Cai
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Transthoracic ultrasound localization microscopy of myocardial vasculature in patients Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-06 Jipeng Yan, Biao Huang, Johanna Tonko, Matthieu Toulemonde, Joseph Hansen-Shearer, Qingyuan Tan, Kai Riemer, Konstantinos Ntagiantas, Rasheda A. Chowdhury, Pier D. Lambiase, Roxy Senior, Meng-Xing Tang
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Durable lymph-node expansion is associated with the efficacy of therapeutic vaccination Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-06 Alexander J. Najibi, Ryan S. Lane, Miguel C. Sobral, Giovanni Bovone, Shawn Kang, Benjamin R. Freedman, Joel Gutierrez Estupinan, Alberto Elosegui-Artola, Christina M. Tringides, Maxence O. Dellacherie, Katherine Williams, Hamza Ijaz, Sören Müller, Shannon J. Turley, David J. Mooney
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How to hit the allergy target: A critical appraisal of intralymphatic immunotherapy with practical recommendations on ultrasound‐guided injections Allergy (IF 12.4) Pub Date : 2024-05-07 Stephan Flory, Bjarke Hviid‐Vyff, Lara Šošić, Johannes M. Schmid, Lars Ahlbeck, Emma C. J. Widmer, Claudia C. V. Lang, Kristian Ikenberg, Thomas M. Kündig, Hans Jürgen Hoffmann, Pål Johansen
BackgroundIntralymphatic immunotherapy (ILIT) represents a promising novel approach treating allergic diseases. However, no standardized procedures or recommendations have been established or reported, despite the recognized fact that treatment efficacy relies on the ability to inject the allergen intranodally.ObjectiveWe aim to provide a critical appraisal of ILIT as a method of allergen immunotherapy
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Images in Dermatology: Dermatomyositis J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-05-06 Pelin Sagut MD, Dirk M. Elston MD
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Development of an mRNA-based therapeutic vaccine mHTV-03E2 for high-risk HPV-related malignancies Mol. Ther. (IF 12.4) Pub Date : 2024-05-06 Jing Wang, Qixin Wang, Ling Ma, Kai Lv, Lu Han, Yunfeng Chen, Rui Zhou, Haokun Zhou, Hua Chen, Yi Wang, Tingting Zhang, Dongrong Yi, Qian Liu, Yongxin Zhang, Xiaoyu Li, Tingting Cheng, Jinming Zhang, Chunjian Huang, Yijie Dong, Weiguo Zhang, Shan Cen
Human papillomavirus (HPV) 16 and 18 infections are related to many human cancers. Despite several preventive vaccines for high-risk (hr) HPVs, there is still an urgent need to develop therapeutic HPV vaccines for targeting pre-existing hrHPV infections and lesions. In this study, we developed a lipid nanoparticle (LNP)-formulated mRNA-based HPV therapeutic vaccine (mHTV)-03E2, simultaneously targeting
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Correspondence to “The effectiveness of pollen allergen immunotherapy on allergic rhinitis over 18 years: A national cohort study in Denmark” Allergy (IF 12.4) Pub Date : 2024-05-06 Celeste Porsbjerg, Benedikt Fritzsching, Nick Freemantle, Marco Contoli, Andreas Kallsoy Slættanes, Christian Woehlk
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Mouse IgE clone SPE‐7 can contain functional mouse IgG Allergy (IF 12.4) Pub Date : 2024-05-06 Michalina Sypka, Marianne Zwicker, Sophie Braga Lagache, Anne‐Christine Uldry, Monique Vogel, Paul Engeroff
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Optical coherence tomography choroidal enhancement using generative deep learning npj Digit. Med. (IF 15.2) Pub Date : 2024-05-04 Valentina Bellemo, Ankit Kumar Das, Syna Sreng, Jacqueline Chua, Damon Wong, Janika Shah, Rahul Jonas, Bingyao Tan, Xinyu Liu, Xinxing Xu, Gavin Siew Wei Tan, Rupesh Agrawal, Daniel Shu Wei Ting, Liu Yong, Leopold Schmetterer
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Sync fast and solve things—best practices for responsible digital health npj Digit. Med. (IF 15.2) Pub Date : 2024-05-04 Constantin Landers, Alessandro Blasimme, Effy Vayena
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Artificial intelligence in digital pathology: a systematic review and meta-analysis of diagnostic test accuracy npj Digit. Med. (IF 15.2) Pub Date : 2024-05-04 Clare McGenity, Emily L. Clarke, Charlotte Jennings, Gillian Matthews, Caroline Cartlidge, Henschel Freduah-Agyemang, Deborah D. Stocken, Darren Treanor
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A physiologically-based digital twin for alcohol consumption—predicting real-life drinking responses and long-term plasma PEth npj Digit. Med. (IF 15.2) Pub Date : 2024-05-03 Henrik Podéus, Christian Simonsson, Patrik Nasr, Mattias Ekstedt, Stergios Kechagias, Peter Lundberg, William Lövfors, Gunnar Cedersund
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FFA-GPT: an automated pipeline for fundus fluorescein angiography interpretation and question-answer npj Digit. Med. (IF 15.2) Pub Date : 2024-05-03 Xiaolan Chen, Weiyi Zhang, Pusheng Xu, Ziwei Zhao, Yingfeng Zheng, Danli Shi, Mingguang He
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Four years into the COVID‐19 pandemic: Timely published articles for patient care and EAACI's leadership role Allergy (IF 12.4) Pub Date : 2024-05-04 María José Torres, Ludger Klimek, Ioana Agache, Marek Jutel, Mübeccel Akdis, Mohamed H. Shamji, Cezmi A. Akdis
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Antibody drug conjugates in the clinic Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-05-04 Edidiong Udofa, Disha Sankholkar, Samir Mitragotri, Zongmin Zhao
Antibody‐drug conjugates (ADCs), chemotherapeutic agents conjugated to an antibody to enhance their targeted delivery to tumors, represent a significant advancement in cancer therapy. ADCs combine the precise targeting capabilities of antibodies and the potent cell‐killing effects of chemotherapy, allowing for enhanced cytotoxicity to tumors while minimizing damage to healthy tissues. Here, we provide
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Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-03 Ningyuan Wen, Dingzhong Peng, Xianze Xiong, Geng Liu, Guilin Nie, Yaoqun Wang, Jianrong Xu, Shaofeng Wang, Sishu Yang, Yuan Tian, Bei Li, Jiong Lu, Nansheng Cheng
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Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-05-03 Rao Fu, Ruoyao Qi, Hualong Xiong, Xing Lei, Yao Jiang, Jinhang He, Feng Chen, Liang Zhang, Dekui Qiu, Yiyi Chen, Meifeng Nie, Xueran Guo, Yuhe Zhu, Jinlei Zhang, Mingxi Yue, Jiali Cao, Guosong Wang, Yuqiong Que, Mujing Fang, Yingbin Wang, Yixin Chen, Tong Cheng, Shengxiang Ge, Jun Zhang, Quan Yuan, Tianying Zhang, Ningshao Xia
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Constructing personalized characterizations of structural brain aberrations in patients with dementia using explainable artificial intelligence npj Digit. Med. (IF 15.2) Pub Date : 2024-05-02 Esten H. Leonardsen, Karin Persson, Edvard Grødem, Nicola Dinsdale, Till Schellhorn, James M. Roe, Didac Vidal-Piñeiro, Øystein Sørensen, Tobias Kaufmann, Eric Westman, Andre Marquand, Geir Selbæk, Ole A. Andreassen, Thomas Wolfers, Lars T. Westlye, Yunpeng Wang
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Robust language-based mental health assessments in time and space through social media npj Digit. Med. (IF 15.2) Pub Date : 2024-05-02 Siddharth Mangalik, Johannes C. Eichstaedt, Salvatore Giorgi, Jihu Mun, Farhan Ahmed, Gilvir Gill, Adithya V. Ganesan, Shashanka Subrahmanya, Nikita Soni, Sean A. P. Clouston, H. Andrew Schwartz
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mRNA-based therapeutic strategies for cancer treatment Mol. Ther. (IF 12.4) Pub Date : 2024-05-03 Thilelli Taibi, Sehyun Cheon, Fabiana Perna, Ly P. Vu
In the rapidly evolving landscape of medical research, the emergence of RNA-based therapeutics is paradigm shifting. It is mainly driven by the molecular adaptability and capacity to provide precision in targeting. The coronavirus disease 2019 pandemic crisis underscored the effectiveness of the mRNA therapeutic development platform and brought it to the forefront of RNA-based interventions. These
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Chandipura viral glycoprotein (CNV-G) promotes Gectosome generation and enables delivery of intracellular therapeutics Mol. Ther. (IF 12.4) Pub Date : 2024-05-03 Xiaojuan Zhang, Quanbin Xu, Zeyu Liu, Jayson B. Ball, Brandon Black, Saheli Ganguly, Michael E. Harland, Samuel Blackman, Stephanie Bryant, Kristi Anseth, Linda Watkins, Xuedong Liu
Overexpression of vesicular stomatitis virus G protein (VSV-G) elevates the secretion of EVs known as gectosomes, which contain VSV-G. Such vesicles can be engineered to deliver therapeutic macromolecules. We investigated viral glycoproteins from several viruses for their potential in gectosome production and intracellular cargo delivery. Expression of the viral glycoprotein (viral glycoprotein from
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Digitally‐enabled, person‐centred care (PCC) in allergen immunotherapy: An ARIA‐EAACI Position Paper Allergy (IF 12.4) Pub Date : 2024-05-03 Oliver Pfaar, Bernardo Sousa‐Pinto, Nikolaos G. Papadopoulos, Désirée E. Larenas‐Linnemann, Michal Ordak, Maria J. Torres, Ralph Mösges, Ludger Klimek, Torsten Zuberbier, Paolo M. Matricardi, Uwe E. Berger, Markus Berger, Stephanie Dramburg, Vera Mahler, Sanna K. Toppila‐Salmi, Karl‐Christian Bergmann, Markus Ollert, Salvatore Tripodi, Marek Jutel, Ioana Agache, Ibon Eguiluz‐Gracia, G. Walter Canonica
In rhinitis and asthma, several mHealth apps have been developed but only a few have been validated. However, these apps have a high potential for improving person‐centred care (PCC), especially in allergen immunotherapy (AIT). They can provide support in AIT initiation by selecting the appropriate patient and allergen shared decision‐making. They can also help in (i) the evaluation of (early) efficacy
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Efficacy and safety of a 7‐week immunotherapy protocol with aluminium hydroxide adsorbed hymenoptera venom Allergy (IF 12.4) Pub Date : 2024-05-03 Bogusia Kasternow, Da‐In S. Kim, Patrick F. K. Yong
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A stretchable, electroconductive tissue adhesive for the treatment of neural injury Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-05-03 Jharana Dhal, Mahsa Ghovvati, Avijit Baidya, Ronak Afshari, Curtis L. Cetrulo, Reza Abdi, Nasim Annabi
Successful nerve repair using bioadhesive hydrogels demands minimizing tissue–material interfacial mechanical mismatch to reduce immune responses and scar tissue formation. Furthermore, it is crucial to maintain the bioelectrical stimulation‐mediated cell‐signaling mechanism to overcome communication barriers within injured nerve tissues. Therefore, engineering bioadhesives for neural tissue regeneration
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Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18 Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-02 David W. Wolfson, Nam Kyun Kim, Ki Hong Lee, Jared P. Beyersdorf, Jonathan J. Langberg, Natasha Fernandez, Dahim Choi, Nadine Zureick, Tae Yun Kim, Seongho Bae, Jin-Mo Gu, Jonathan L. Kirschman, Jinqi Fan, Christina Y. Sheng, Danielle Gottlieb Sen, Bret Mettler, Jung Hoon Sung, Young-sup Yoon, Sung-Jin Park, Philip J. Santangelo, Hee Cheol Cho
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A critical assessment of using ChatGPT for extracting structured data from clinical notes npj Digit. Med. (IF 15.2) Pub Date : 2024-05-01 Jingwei Huang, Donghan M. Yang, Ruichen Rong, Kuroush Nezafati, Colin Treager, Zhikai Chi, Shidan Wang, Xian Cheng, Yujia Guo, Laura J. Klesse, Guanghua Xiao, Eric D. Peterson, Xiaowei Zhan, Yang Xie
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Video clips for patient comprehension of atrial fibrillation and deep vein thrombosis in emergency care. A randomised clinical trial npj Digit. Med. (IF 15.2) Pub Date : 2024-04-30 Santi Di Pietro, Ilaria Ferrari, Giuseppe Bulgari, Maria Lorenza Muiesan, Francesco Falaschi, Annalisa De Silvestri, Luigia Scudeller, Valeria Musella, Simone Saglio, Beatrice Re, Elena Mattiuzzo, Fabio Cherubini, Stefano Perlini
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RETFound-enhanced community-based fundus disease screening: real-world evidence and decision curve analysis npj Digit. Med. (IF 15.2) Pub Date : 2024-04-30 Juzhao Zhang, Senlin Lin, Tianhao Cheng, Yi Xu, Lina Lu, Jiangnan He, Tao Yu, Yajun Peng, Yuejie Zhang, Haidong Zou, Yingyan Ma
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Targeted desialylation and cytolysis of tumour cells by fusing a sialidase to a bispecific T-cell engager Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-05-01 Zhuo Yang, Yingqin Hou, Geramie Grande, Jong Hyun Cho, Chao Wang, Yujie Shi, Jaroslav Zak, Yue Wan, Ke Qin, Dongfang Liu, John R. Teijaro, Richard A. Lerner, Peng Wu