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Technology-supported behavior change interventions for reducing sodium intake in adults: a systematic review and meta-analysis npj Digit. Med. (IF 15.2) Pub Date : 2024-03-18 Yong Yang Yan, Lily Man Lee Chan, Man Ping Wang, Jojo Yan Yan Kwok, Craig S. Anderson, Jung Jae Lee
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Towards on-skin analysis of sweat for managing disorders of substance abuse Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-18 Noe Brasier, Juliane R. Sempionatto, Steven Bourke, George Havenith, Dietmar Schaffarczyk, Jörg Goldhahn, Christian Lüscher, Wei Gao
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Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-18 Surabhi R. Madhvapathy, Matthew I. Bury, Larry W. Wang, Joanna L. Ciatti, Raudel Avila, Yonggang Huang, Arun K. Sharma, John A. Rogers
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Bacteria-mediated resistance of neutrophil extracellular traps to enzymatic degradation drives the formation of dental calculi Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-15 Mei-chen Wan, Kai Jiao, Yi-na Zhu, Qian-qian Wan, Yi-peng Zhang, Long-zhang Niu, Chen Lei, Jing-han Song, Wei-cheng Lu, Hua-jie Liu, Zhao-yang Ren, Franklin Tay, Li-na Niu
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An aligned framework of actively collected and passively monitored clinical outcome assessments (COAs) for measure selection npj Digit. Med. (IF 15.2) Pub Date : 2024-03-16 Christine Manta Campbell, Courtney Webster, Megan Parisi, Roya Sherafat-Kazemzadeh, Jessica Braid, Thomas Switzer, Marcelo Alves Fávaro, Caprice Sassano, Andrea Coravos
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Physical activity and sleep changes among children during the COVID-19 pandemic npj Digit. Med. (IF 15.2) Pub Date : 2024-03-16 Karnika Singh, Sarah C. Armstrong, Brooke E. Wagner, Julie Counts, Asheley Skinner, Melissa Kay, Jennifer S. Li, Svati Shah, Nancy Zucker, Cody Neshteruk, Mary Story, Lilianna Suarez, William E. Kraus, Alexandra R. Zizzi, Jessilyn Dunn
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The lucent yet opaque challenge of regulating artificial intelligence in radiology npj Digit. Med. (IF 15.2) Pub Date : 2024-03-15 James M. Hillis, Jacob J. Visser, Edward R. Scheffer Cliff, Kelly van der Geest – Aspers, Bernardo C. Bizzo, Keith J. Dreyer, Jeremias Adams-Prassl, Katherine P. Andriole
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Indigenous data governance approaches applied in research using routinely collected health data: a scoping review npj Digit. Med. (IF 15.2) Pub Date : 2024-03-15 Teyl Engstrom, Elton H. Lobo, Kristie Watego, Carmel Nelson, Jinxiang Wang, Howard Wong, Sungkyung Linda Kim, Soo In Oh, Michael Lawley, Alain-Dominique Gorse, James Ward, Clair Sullivan
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Human induced pluripotent stem cells‐derived liver organoids grown on a Biomimesys® hyaluronic acid‐based hydroscaffold as a new model for studying human lipoprotein metabolism Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-03-16 Meryl Roudaut, Amandine Caillaud, Zied Souguir, Lise Bray, Aurore Girardeau, Antoine Rimbert, Mikaël Croyal, Gilles Lambert, Murielle Patitucci, Gaspard Delpouve, Élodie Vandenhaute, Cédric Le May, Nathalie Maubon, Bertrand Cariou, Karim Si‐Tayeb
The liver plays a key role in the metabolism of lipoproteins, controlling both production and catabolism. To accelerate the development of new lipid‐lowering therapies in humans, it is essential to have a relevant in vitro study model available. The current hepatocyte‐like cells (HLCs) models derived from hiPSC can be used to model many genetically driven diseases but require further improvement to
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Protein lipidation in health and disease: molecular basis, physiological function and pathological implication Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-15 Yuan Yuan, Peiyuan Li, Jianghui Li, Qiu Zhao, Ying Chang, Xingxing He
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Tolerability of a piezoelectric microneedle electroporator in human subjects Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-03-15 Chao‐Yi Lu, Pankaj Rohilla, Eric I. Felner, Gaurav Byagathvalli, Erkan Azizoglu, M. Saad Bhamla, Mark R. Prausnitz
Electroporation, or the use of electric pulses to facilitate the intracellular delivery of DNA, RNA, and other molecules, is a well‐established technique, that has been demonstrated to significantly augment the immunogenicity of DNA/mRNA vaccines and therapeutics. However, the clinical translation of traditional electroporators has been limited due to high costs, large size, complex user operation
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Informing immunotherapy with multi-omics driven machine learning npj Digit. Med. (IF 15.2) Pub Date : 2024-03-14 Yawei Li, Xin Wu, Deyu Fang, Yuan Luo
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Characterising user engagement with mHealth for chronic disease self-management and impact on machine learning performance npj Digit. Med. (IF 15.2) Pub Date : 2024-03-12 Christopher Duckworth, Bethany Cliffe, Brian Pickering, Ben Ainsworth, Alison Blythin, Adam Kirk, Thomas M. A. Wilkinson, Michael J. Boniface
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In vivo affinity maturation of mouse B cells reprogrammed to express human antibodies Nat. Biomed. Eng. (IF 28.1) Pub Date : 2024-03-14 Yiming Yin, Yan Guo, Yuxuan Jiang, Brian Quinlan, Haiyong Peng, Gogce Crynen, Wenhui He, Lizhou Zhang, Tianling Ou, Charles C. Bailey, Michael Farzan
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Diagnostic utility of gingival biopsy for pemphigus vulgaris and mucosa membrane pemphigoid: A 10-year cohort study J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-14 Junjiang Liu MMed, Can Hu MBBS, Jing He MBBS, Jingtian Mu MMed, Shimeng Wang PhD, Qi Han PhD, Jia Li BS, Mei Lin MMed, Qinghong Gao PhD, Fanglong Wu PhD, Hongmei Zhou PhD
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Risk of Systemic Lymphoma in Patients with Cutaneous CD30+ Lymphoproliferative Disorders: A Single Center Retrospective Cohort Analysis J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-14 Jennifer Chen MD, Abigail Martinez BS, Michi M. Shinohara MD
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Differentiating generalized pustular psoriasis from acute generalized exanthematous pustulosis J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-14 Mika Yamanaka-Takaichi MD PhD, Miki Watanabe MD, Nneka I. Comfere MD, Olayemi Sokumbi MD, Christeebella O. Akpala RN, Austin Todd MS, Emily L. Branch CCRP, Aaron R. Mangold MD, Sho Hiroyasu MD PhD, Daisuke Tsuruta MD PhD, Afsaneh Alavi MD
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Nasal allergen‐neutralizing antibodies correlate closely with tolerated intranasal allergen challenge dose following grass pollen subcutaneous immunotherapy in patients with local allergic rhinitis Allergy (IF 12.4) Pub Date : 2024-03-14 Ibon Eguiluz‐Gracia, Rebecca V. Parkin, Janice A. Layhadi, Elizabeth Palmer, Xun Meng, Rongfei Zhu, Umit Sahiner, Stephen R. Durham, Maria Jose Torres, Cristobalina Mayorga, Carmen Rondon, Mohamed H. Shamji
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Diabetes and pulmonary infection: how hyperglycaemia shapes the immune system Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-13 Christian Herder, Michael Roden, Nicolas Venteclef
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Th2 response drives itch in dystrophic epidermolysis bullosa pruriginosa: a case-control study J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-13 Marieta Papanikolaou MBBS PhD, Leigh Nattkemper PhD, Natashia Benzian-Olsson MSc, Lu Liu PhD, Alyson Guy, Han Lu PhD, Tendai Kadiyirire MRes BSc, Ping-Chen Hou MD, Wilson Aala MSc, Sonia Serrano BSc, Rashida Pramanik BSc, Nina Walters MSc, Konstantina Dimitrakopoulou PhD, Su Lwin MBBS PhD, Emily Kalfas, Jose Satoc MSc, Roman Laddach MRes, Domenico Cozzetto PhD, Bjorn Thomas MBBS PhD, Evangelia Kesidou
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No impact of immunomodulatory treatments on SARS-CoV-2 (COVID-19) vaccine outcomes: A cross-sectional analysis of biologic and small molecule inhibitors used for psoriasis and hidradenitis suppurativa patients from the Epic® Cosmos database J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-13 Bella R. Lee BS, Autumn R. Brostek BA, Benjamin H. Kaffenberger MD MS
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Dermatology images: Monkeypox (MPOX) J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-13 Andrés Grau-Echevarría M.D., Rodrigo Peñuelas-Leal. M.D., Carolina Labrandero-Hoyos M.D., Javier Lorca-Spröhnle M. D., Daniel Blaya-Imbernón M.D., Malena Finello M.D., Amparo Pérez-Ferriols M.D. Ph.D., Pablo Hernández-Bel M.D. Ph.D.
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The role of the mitochondrial protein VDAC1 in inflammatory bowel disease: a potential therapeutic target Mol. Ther. (IF 12.4) Pub Date : 2024-03-13 Ankit Verma, Srinivas Pittala, Belal Alhozeel, Anna Shteinfer-Kuzmine, Ehud Ohana, Rajeev Gupta, Jay H. Chung, Varda Shoshan-Barmatz
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High burden of clonal mast cell disorders and hereditary α‐tryptasemia in patients who need Hymenoptera venom immunotherapy Allergy (IF 12.4) Pub Date : 2024-03-13 Peter Korošec, Gunter J. Sturm, Jonathan J. Lyons, Tinkara Pirc Marolt, Manca Svetina, Mitja Košnik, Mihaela Zidarn, Mark Kačar, Nina Frelih, Nika Lalek, Ajda Demšar Luzar, Samo Zver, Matevž Škerget, Ewa Czarnobilska, Wojciech Dyga, Sanja Popović Grle, Miroslav Samarzija, Lisa Arzt‐Gradwohl, Urban Čerpes, Grzegorz Porebski, Branko Pevec, Eva Schadelbauer, Peter Kopač, Julij Šelb, Matija Rijavec
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RNA‐sequencing of paired tape‐strips and skin biopsies in atopic dermatitis reveals key differences Allergy (IF 12.4) Pub Date : 2024-03-13 Blaine Fritz, Anne‐Sofie Halling, Isabel Díaz‐Pinés Cort, Maria Oberländer Christensen, Amalie Thorsti Møller Rønnstad, Caroline Meyer Olesen, Mette Hjorslev Knudgaard, Claus Zachariae, Steffen Heegaard, Jacob P. Thyssen, Thomas Bjarnsholt
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Evaluation of a novel vaginal cells self‐sampling device for human papillomavirus testing in cervical cancer screening: A clinical trial assessing reliability and acceptability Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-03-13 Chung‐Yao Yang, Ting‐Chang Chang, Hung‐Hsueh Chou, Angel Chao, Shih‐Tien Hsu, Yu‐Hsiang Shih, Huei‐Jean Huang, Cheng‐Tao Lin, Min‐Yu Chen, Lou Sun, Kuan‐Gen Huang, Kai‐Yun Wu, Wu‐Chiao Hsieh, Yi‐Ting Huang, Liang‐Hsuan Chen, Chien‐Hsing Lu, Hao Lin, Chao‐Min Cheng
Cervical cancer is a significant public health concern, particularly in low‐ and middle‐income countries where resources for prevention and treatment are limited. Routine screening, such as the Papanicolaou test (Pap smears) and human papillomavirus (HPV) testing, plays a crucial role in the early detection and prevention of cervical cancer. However, the participation rate in cervical cancer screening
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Synchronously in vivo real‐time monitoring bacterial load and temperature with evaluating immune response to decipher bacterial infection Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-03-13 Huaixuan Sheng, Huizhu Li, Shunyao Li, Chengxuan Yu, Yueming Wang, Haichen Hu, Lu Fang, Fuchun Chen, Yanyan Lu, Xiaogang Xu, Xing Yang, Shiyi Chen, Yuefeng Hao, Yunxia Li, Sijia Feng, Jun Chen
Determining the precise course of bacterial infection requires abundant in vivo real‐time data. Synchronous monitoring of the bacterial load, temperature, and immune response can satisfy the shortage of real‐time in vivo data. Here, we conducted a study in the joint‐infected mouse model to synchronously monitor the bacterial load, temperature, and immune response using the second near‐infrared (NIR‐II)
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Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-12 Zhenzhen Fang, Gang Shen, Yina Wang, Fuyan Hong, Xiumei Tang, Yongcheng Zeng, Ting Zhang, Huanyi Liu, Yanmei Li, Jinhong Wang, Jing Zhang, Anton Gao, Weiwei Qi, Xia Yang, Ti Zhou, Guoquan Gao
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Retrospective Analysis of Multiple Myeloma Drug Use in Cutaneous Toxicity of MGUS J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-12 Emily R. Gordon BA, Caroline Chen BA, Oluwaseyi Adeuyan BS, Brigit A. Lapolla BS, Megan H. Trager MD, Lauren M. Fahmy BS, Celine M. Schreidah BS, David A. Wetter MD, Larisa J. Geskin MD
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Prosthetic resin nail improves quality of life in patients with retronychia in a single-center clinical trial J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-12 Kaya L. Curtis BA, Jose W. Ricardo MD, Bilal Shaikh MS, Tracey C. Vlahovic DPM RCPS (Glasg), Shari R. Lipner MD PhD
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Correction to Long‐term immune response accompanies clinical outcomes in severe asthmatics treated with anti‐IL‐5/IL‐5R biologics Allergy (IF 12.4) Pub Date : 2024-03-12
Citation: Lorente-Sorolla C, Bernaola J, Sánchez-Mellado D, Gil-Martínez M, Naharro-González S, Betancor D, Fernández-Nieto M, Pinillos-Robles EJ, Santillán Coello JM, Villacampa-Aubá JM, Rodríguez-Nieto MJ, Sastre J, Valverde-Monge M, Rodrigo-Muñoz JM, Del Pozo V. Long-term immune response accompanies clinical outcomes in severe asthmatics treated with anti-IL-5/IL-5R biologics. Allergy. 2023 Nov;78(11):3027-3031
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Siglec15/TGF‐β bispecific antibody mediates synergistic anti‐tumor response against 4T1 triple negative breast cancer in mice Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-03-12 Limei Shen, Alison M. Schaefer, Karthik Tiruthani, Whitney Wolf, Samuel K. Lai
An ideal tumor‐specific immunomodulatory therapy should both preferentially target the tumor, while simultaneously reduce the immunosuppressive environment within the tumor. This guiding principle led us to explore engineering Siglec‐15 (S15) targeted bispecific antibody (bsAb) to enhance therapy against triple negative breast cancer (TNBC). S15 appears to be exclusively expressed on macrophages and
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Disparities in pediatric anaphylaxis triggers and management across Asia Allergy (IF 12.4) Pub Date : 2024-03-10 Agnes Sze Yin Leung, Elizabeth Huiwen Tham, Punchama Pacharn, Yuhan Xing, Hoang Kim Tu Trinh, Sooyoung Lee, Kangmo Ahn, Pantipa Chatchatee, Sakura Sato, Motohiro Ebisawa, Bee Wah Lee, Gary Wing Kin Wong
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Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-11 Yu-Ling Xiao, Yue Gong, Ying-Jia Qi, Zhi-Ming Shao, Yi-Zhou Jiang
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Efficacy and safety of PD-1 blockade plus long-course chemoradiotherapy in locally advanced rectal cancer (NECTAR): a multi-center phase 2 study Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-11 Zhengyang Yang, Jiale Gao, Jianyong Zheng, Jiagang Han, Ang Li, Gang Liu, Yi Sun, Jie Zhang, Guangyong Chen, Rui Xu, Xiao Zhang, Yishan Liu, Zhigang Bai, Wei Deng, Wei He, Hongwei Yao, Zhongtao Zhang
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Tet methylcytosine dioxygenase 2 (TET2) deficiency elicits EGFR-TKI (tyrosine kinase inhibitors) resistance in non-small cell lung cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-09 Jian Zhang, Kejia Zhao, Wenjing Zhou, Ran Kang, Shiyou Wei, Yueli Shu, Cheng Yu, Yin Ku, Yonghong Mao, Hao Luo, Juqin Yang, Jiandong Mei, Qiang Pu, Senyi Deng, Zhengyu Zha, Gang Yuan, Shensi Shen, Yaohui Chen, Lunxu Liu
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Modeling multiple sclerosis using mobile and wearable sensor data npj Digit. Med. (IF 15.2) Pub Date : 2024-03-11 Shkurta Gashi, Pietro Oldrati, Max Moebus, Marc Hilty, Liliana Barrios, Firat Ozdemir, Veronika Kana, Andreas Lutterotti, Gunnar Rätsch, Christian Holz
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Annual tuberculosis screening in patients on biologics has questionable value J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-11 Madison N. Kist BS, Ryan Svoboda MD MS, Steven Maczuga MS, Li Wang PhD, Galen T. Foulke MD, Matthew F. Helm MD
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The financial burden of scalp cooling therapy: a nonprofit organization data analysis J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-11 Madison Novice B.S., Taylor Novice MD, Molly Powers MD, Kristen I. Lo Sicco MD
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Epidemiologic and clinical differences between early-onset and later-onset childhood vitiligo, a retrospective cohort study J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-11 Li Meiyun MS, Xie Li PhD, Liu Xiaoyi MS, Deng Dan PhD
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Povidone iodine gel use as a conductive and antiseptic in ultrasound-guided invasive procedures. J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-11 P.J. Navarro-Guillamón, M. Valencia-Serrano, J.A. Suarez-Perez, E. Herrera-Acosta
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Syndemic and dermatology: A case study in hidradenitis suppurativa J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-11 Tonia Samela PhD, Giulia Raimondi PhD, Giorgia Cordella PsyD, Luca Fania MD PhD, Francesca Sampogna PhD MPH, Simona Mastroeni MSc, Roberta Fusari MLT, Valeria Antinone PsyD, Damiano Abeni MD MPH
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Reply to the correspondence on “Basophil activation test as predictor of severity and threshold of allergic reactions to egg” Allergy (IF 12.4) Pub Date : 2024-03-11 Alexandra F. Santos, Grammatiki Antoneria, Zainab Jama, Jana Ilangovan, Vikki Houghton
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Prodromal symptoms of hereditary angioedema (HAE) attacks: A patient survey in UK and Spain Allergy (IF 12.4) Pub Date : 2024-03-11 Patrick F. K. Yong, Mar Guilarte
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Correction to “Primary T‐cell‐based delivery platform for in vivo synthesis of engineered proteins” Bioeng. Transl. Med. (IF 7.4) Pub Date : 2024-03-11
Radhakrishnan H, Newmyer SL, Ssemadaali MA, Javitz HS, Bhatnagar P. Primary T-cell-based delivery platform for in vivo synthesis of engineered proteins. Bioeng Transl Med. 2024; 9(1):e10605. doi:10.1002/btm2.10605 Unlike the remainder of the manuscript where the data have been developed using pan CD3 T cells, Figure 4d–f used CD4 T cells. We apologize for this error. Corrections have been disclosed
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Unraveling cradle-to-grave disease trajectories from multilayer comorbidity networks npj Digit. Med. (IF 15.2) Pub Date : 2024-03-07 Elma Dervić, Johannes Sorger, Liuhuaying Yang, Michael Leutner, Alexander Kautzky, Stefan Thurner, Alexandra Kautzky-Willer, Peter Klimek
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Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-08 Qian Zhou, Yu Meng, Daishi Li, Lei Yao, Jiayuan Le, Yihuang Liu, Yuming Sun, Furong Zeng, Xiang Chen, Guangtong Deng
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Cost of hospitalization for care of children with Epidermolysis Bullosa in the US J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-09 Amar D. Desai MPH, Amit Singal BA, Sara Behbahani MD MS, Yssra Soliman MD, Elena B. Hawryluk MD PhD
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Low Incidence of Invasive Fungal Infections in a Large Observational Cohort of Patients Initiating IL-17 or IL-23 Inhibitor Therapy, United States, 2016–2022 J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-09 Nathan C. Bahr MD, Kaitlin Benedict MPH, Mitsuru Toda PhD, Jeremy A.W. Gold MD, Shari R. Lipner MD PhD
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Projected burden of melanoma clinical surveillance in the United States J. Am. Acad. Dermatol. (IF 13.8) Pub Date : 2024-03-09 Natalie H. Matthews MD MPhil, Judy Hamad MD MPH, James B. Henderson PhD, Martin A. Weinstock MD PhD, Charles N. Ellis MD
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Neonatal skin dysbiosis to infantile atopic dermatitis: Mitigating effects of skin care Allergy (IF 12.4) Pub Date : 2024-03-09 Reika Aoyama, Seitaro Nakagawa, Yoko Ichikawa, Naohiro Inohara, Yuriko Yamazaki, Tomoka Ito, Takashi Sugihira, Michihiro Kono, Masashi Akiyama, Hiroki Takahashi, Akiko Takaya, Fumitaka Ichikawa, Taiji Nakano, Seiko Tanaka, Yutaka Koyano, Manabu Fujimoto, Gabriel Núñez, Naoki Shimojo, Yuumi Nakamura
Patients with atopic dermatitis (AD) harbor Staphylococcus aureus in lesional skin, causing dysbiosis, linked to disease flares and progression.1 The onset of dysbiosis-related AD during infancy remains unclear. To clarify this, we performed a longitudinal microbiome analysis in an interventional cohort study. In total, 177 infants, all of whom received skin care, were included in this study (Figure S1A
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Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-08 Yan Fu, Keyu Shen, Hao Wang, Shun Wang, Xufeng Wang, Le Zhu, Yan Zheng, Tiantian Zou, Hongfei Ci, Qiongzhu Dong, Lun-Xiu Qin
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Targeting carnitine palmitoyl transferase 1A (CPT1A) induces ferroptosis and synergizes with immunotherapy in lung cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2024-03-07 Lei Ma, Chong Chen, Chunxing Zhao, Tong Li, Lingyu Ma, Jiayu Jiang, Zhaojun Duan, Qin Si, Tsung-Hsien Chuang, Rong Xiang, Yunping Luo
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Bridging the literacy gap for surgical consents: an AI-human expert collaborative approach npj Digit. Med. (IF 15.2) Pub Date : 2024-03-08 Rohaid Ali, Ian D. Connolly, Oliver Y. Tang, Fatima N. Mirza, Benjamin Johnston, Hael F. Abdulrazeq, Paul F. Galamaga, Tiffany J. Libby, Neel R. Sodha, Michael W. Groff, Ziya L. Gokaslan, Albert E. Telfeian, John H. Shin, Wael F. Asaad, James Zou, Curtis E. Doberstein
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Generative AI and large language models in health care: pathways to implementation npj Digit. Med. (IF 15.2) Pub Date : 2024-03-07 Marium M. Raza, Kaushik P. Venkatesh, Joseph C. Kvedar
Generative AI is designed to create new content from trained parameters. Learning from large amounts of data, many of these models aim to simulate human conversation. Generative AI is being applied to many different sectors. Within healthcare there has been innovation specifically towards generative AI models trained on electronic medical record data. A recent review characterizes these models, their
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To warrant clinical adoption AI models require a multi-faceted implementation evaluation npj Digit. Med. (IF 15.2) Pub Date : 2024-03-06 Davy van de Sande, Eline Fung Fen Chung, Jacobien Oosterhoff, Jasper van Bommel, Diederik Gommers, Michel E. van Genderen
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Legends of allergy and immunology: Kenji Izuhara Allergy (IF 12.4) Pub Date : 2024-03-08 Satoshi Nunomura, Kazunari Sugita, Kazuhiko Arima
CONFLICT OF INTEREST STATEMENT Satoshi Nunomura and Kazunari Sugita have no conflicts to declare, while Kazuhiko Arima is a full-time employee and stockholder of Sanofi K.K.
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In vivo base editing of a pathogenic Eif2b5 variant improves vanishing white matter phenotypes in mice Mol. Ther. (IF 12.4) Pub Date : 2024-03-07 Desirée Böck, Ilma M. Revers, Anastasia S.J. Bomhof, Anne E.J. Hillen, Claire Boeijink, Lucas Kissling, Sabina Egli, Miguel A. Moreno-Mateos, Marjo S. van der Knaap, Niek P. van Til, Gerald Schwank
Vanishing white matter (VWM) is a fatal leukodystrophy caused by recessive mutations in subunits of the eukaryotic translation initiation factor 2B. Currently, there are no effective therapies for VWM. Here, we assessed the potential of adenine base editing to correct human pathogenic VWM variants in mouse models. Using adeno-associated viral vectors, we delivered intein-split adenine base editors
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The extracellular cyclophilin A-integrin β2 complex as a therapeutic target of viral pneumonia Mol. Ther. (IF 12.4) Pub Date : 2024-03-07 Xiaoyuan Bai, Wenxian Yang, Yuna Zhao, Tongtong Cao, Runshan Lin, Pengtao Jiao, Heqiao Li, Huizi Li, Jie Min, Xiaoxiao Jia, He Zhang, Wenhui Fan, Xiaojuan Jia, Yuhai Bi, Wenjun Liu, Lei Sun
The acute respiratory virus infection can induce uncontrolled inflammatory responses, such as cytokine storm and viral pneumonia, which are the major causes of death in clinical cases. Cyclophilin A (CypA) is mainly distributed in the cytoplasm of resting cells and released into the extracellular space in response to inflammatory stimuli. Extracellular CypA (eCypA) is upregulated and promotes inflammatory
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ANKRD22 promotes resolution of psoriasiform skin inflammation by antagonizing NIK-mediated IL-23 production Mol. Ther. (IF 12.4) Pub Date : 2024-03-07 Xichun Xia, Leqing Zhu, Miaomiao Xu, Zhiwei Lei, Hai Yu, Guangqiang Li, Xiao Wang, Hongling Jia, Zhinan Yin, Fang Huang, Yunfei Gao
Inflammation resolution is an essential process for preventing the development of chronic inflammatory diseases. However, the mechanisms that regulate inflammation resolution in psoriasis are not well understood. Here, we report that ANKRD22 is an endogenous negative orchestrator of psoriasiform inflammation because ANKRD22-deficient mice are more susceptible to IMQ-induced psoriasiform inflammation