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The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study Mol. Psychiatry (IF 9.6) Pub Date : 2025-02-08 M. Bocharova, T. Borza, L. O. Watne, K. Engedal, J. T. O’Brien, G. Selbæk, A. V. Idland, J. Hodsoll, A. H. Young, D. Aarsland
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βIV spectrin abundancy, cellular distribution and sensitivity to AKT/GSK3 regulation in schizophrenia Mol. Psychiatry (IF 9.6) Pub Date : 2025-02-07 Jessica Di Re, Michela Marini, Syed Ibrar Hussain, Aditya K. Singh, Akshaya Venkatesh, Musaad A. Alshammari, Tahani K. Alshammari, Abdul-Rizaq Ali Hamoud, Ali Sajid Imami, Zahra Haghighijoo, Nickolas Fularcyzk, Laura Stertz, Derek Hawes, Angela Mosebarger, Jordan Jernigan, Claire Chaljub, Ralda Nehme, Consuelo Walss-Bass, Anton Schulmann, Marquis P. Vawter, Robert McCullumsmith, Robert D. Damoiseaux
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Professorships in child and adolescent psychiatry relative to a similarly sized medical specialty in the UK and Ireland: cross-sectional study Br. J. Psychiatry (IF 8.7) Pub Date : 2025-02-07 Ian Kelleher, Aleksandra Z. Poziemska, Valentina Kieseppä, Anita Thapar, Bernadka Dubicka, Elaine Lockhart, Tamsin Ford, Helen Minnis, Louise Gallagher, Fiona McNicholas, Kirstie O'Hare
Background A youth mental health crisis is considered one of the great challenges of our time, and research and clinical services in child and adolescent psychiatry have become a priority for governments and funders. Academic leadership is needed to drive forward research. It is not clear how many senior academic leadership posts (professorships) there are in child and adolescent psychiatry, nor how
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Real-world effectiveness of pharmacological maintenance treatment of bipolar depression: a within-subject analysis in a Swedish nationwide cohort Lancet Psychiatry (IF 30.8) Pub Date : 2025-02-05 Cagatay Ermis, Heidi Taipale, Antti Tanskanen, Eduard Vieta, Christoph U Correll, Ellenor Mittendorfer-Rutz, Jari Tiihonen
BackgroundLong-term add-on antidepressant use for bipolar depression remains controversial. This study aimed to investigate primarily the association between psychopharmacological treatments and hospitalisation (ie, hospital admission) for bipolar depression, and secondarily the association between psychopharmacological treatments and hospitalisation for bipolar mania and somatic reasons in a registry-based
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Trump 2.0: a better way to show leadership Lancet Psychiatry (IF 30.8) Pub Date : 2025-02-05
No Abstract
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Lithium for depression-related hospitalisation in bipolar disorder Lancet Psychiatry (IF 30.8) Pub Date : 2025-02-05 Balwinder Singh
No Abstract
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Is it now time to prepare psychiatry for a psychedelic future?: commentary, Breen et al. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-02-06 Eugene G Breen,Faisal Al-Harbi
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Effective Treatment for Mental and Substance Use Disorders in 21 Countries. JAMA Psychiatry (IF 22.5) Pub Date : 2025-02-05 Daniel V Vigo,Dan J Stein,Meredith G Harris,Alan E Kazdin,Maria Carmen Viana,Richard Munthali,Lonna Munro,Irving Hwang,Timothy L Kessler,Sophie M Manoukian,Nancy A Sampson,Ronald C Kessler,
Importance Accurate baseline information about the proportion of people with mental disorders who receive effective treatment is required to assess the success of treatment quality improvement initiatives. Objective To examine the proportion of mental and substance use disorders receiving guideline-consistent treatment in multiple countries. Design, Setting, and Participants In this cross-sectional
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Observational and Genetic Analyses of Traumatic Experiences and Endometriosis JAMA Psychiatry (IF 22.5) Pub Date : 2025-02-05 Dora Koller, Solveig Løkhammer, Oksana Goroshchuk, Veronika Denner, Brendan Stiltner, Marina Mitjans, Jun He, Hugh S. Taylor, Rebecca B. Lawn, Karestan C. Koenen, Renato Polimanti
ImportanceAlthough psychological traumas have been associated with endometriosis, limited information is available regarding the role of trauma type and genetic predisposition.ObjectiveTo examine the relationship between traumatic experiences and endometriosis using observational and genetically informed analyses.Design, Setting, and ParticipantsFor this case-control study, the analyses were performed
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An Opportunity to Advance Cannabis Science—DEA Rescheduling JAMA Psychiatry (IF 22.5) Pub Date : 2025-02-05 Kevin P. Hill, Anshul V. Puli
This Viewpoint discusses the regulatory and financial barriers to cannabis research, and the potential changes to these barriers if cannabis is reclassified as a Schedule III drug.
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Maternal immune activation imprints translational dysregulation and differential MAP2 phosphorylation in descendant neural stem cells Mol. Psychiatry (IF 9.6) Pub Date : 2025-02-03 Sandra M. Martín-Guerrero, María Martín-Estebané, Antonio J. Lara Ordóñez, Miguel Cánovas, David Martín-Oliva, Javier González-Maeso, Pedro R. Cutillas, Juan F. López-Giménez
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Neural correlates of personal space regulation in psychosis: role of the inferior parietal cortex Mol. Psychiatry (IF 9.6) Pub Date : 2025-02-03 Louis N. Vinke, Mona Avanaki, Clayton Jeffrey, Amritha Harikumar, Jessica L. Mow, Roger B. H. Tootell, Nicole R. DeTore, Daphne J. Holt
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Aberrant Functional Connectivity and Brain Network Organization in High-Schizotypy Individuals: An Electroencephalography Study Schizophr. Bull. (IF 5.3) Pub Date : 2025-02-04 Jelena Trajkovic, Giulia Ricci, Gabriele Pirazzini, Luca Tarasi, Francesco Di Gregorio, Elisa Magosso, Mauro Ursino, Vincenzo Romei
Background and Hypothesis Oscillatory synchrony plays a crucial role in establishing functional connectivity across distinct brain regions. Within the realm of schizophrenia, suggested to be a neuropsychiatric disconnection syndrome, discernible aberrations arise in the organization of brain networks. We aim to investigate whether the resting-state functional network is already altered in healthy individuals
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Neural processes linking joint hypermobility and anxiety: key roles for the amygdala and insular cortex Br. J. Psychiatry (IF 8.7) Pub Date : 2025-02-03 Christina N. Kampoureli, Charlotte L. Rae, Cassandra Gould Van Praag, Neil A. Harrison, Sarah N. Garfinkel, Hugo D. Critchley, Jessica A. Eccles
Background Anxiety symptoms are elevated among people with joint hypermobility. The underlying neural mechanisms are attributed theoretically to effects of variant connective tissue on the precision of interoceptive representations contributing to emotions.Aim To investigate the neural correlates of anxiety and hypermobility using functional neuroimaging.Method We used functional magnetic resonance
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Internet-Based Cognitive-Behavioral Therapy Intervention Master Your Worries With Telephone Coaching for Anxious Finnish Children Aged 10-13 Years: A Population-Based Randomized Controlled Trial. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-02-03 Andre Sourander,Tarja Korpilahti-Leino,Katri Kaajalaakso,Terja Ristkari,Susanna Hinkka-Yli-Salomäki,Tiia Ståhlberg,Terhi Luntamo
OBJECTIVE No previous studies have evaluated the efficacy of internet-based cognitive behavioral therapy (ICBT) among children below age 13 screened at the population level. This study was an open two parallel-group RCT, stratified by sex, that compared ICBT with telephone coaching to an educational control. METHOD Altogether 465 children (mean age 11.5, SD 1.0, 71.4% girls) were randomly allocated
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Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence Mol. Psychiatry (IF 9.6) Pub Date : 2025-02-01 Qingyang Li, Miao Cao, Dan J. Stein, Barbara J. Sahakian, Tianye Jia, Christelle Langley, Zixin Gu, Wenjie Hou, Han Lu, Luolong Cao, Jinran Lin, Runye Shi, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka
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Stress-induced changes in the molecular processes underlying fear memories: implications for PTSD and relevant animal models Mol. Psychiatry (IF 9.6) Pub Date : 2025-01-31 Raül Andero
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Dopaminergic deficits along the spectrum of Alzheimer’s disease Mol. Psychiatry (IF 9.6) Pub Date : 2025-01-31 Andrea Pilotto, Alice Galli, Arianna Sala, Silvia Paola Caminiti, Luca Presotto, Claudio Liguori, Nicola Biagio Mercuri, Enrico Premi, Valentina Garibotto, Giovanni Frisoni, Agostino Chiaravalloti, Orazio Schillaci, Marcello D’Amelio, Barbara Paghera, Silvia Lucchini, Francesco Bertagna, Daniela Perani, Alessandro Padovani
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Tobacco, Alcohol, Heroin, Binge Eating, and Behavioral Addictions. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Ned H Kalin
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Prospective Associations Between Tobacco Product Use and Mental Health and Substance Use Problems Among U.S. Adolescents and Adults. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Kevin P Conway,Emmanuella Michel,Sam Eig,Jian-Ping He,Kathleen R Merikangas
OBJECTIVE The authors examined prospective associations between tobacco product use and mental health and substance use problems among U.S. adolescents and adults. METHODS Covariate-adjusted models using discrete-time survival analysis of five annual waves (2013-2014 to 2018-2019) were used to examine the links between specific tobacco product use and mental health and substance use problems among
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Tobacco Use Is Associated With Mental Illness and Substance Use Problems-Now What? Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Judith J Prochaska
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Real-Time Assessment of Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and Depressive Disorders. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Andrea C King,Andrew M Fischer,John F Cursio,Nathan A Didier,Zoe Lee,Daniel J Fridberg
OBJECTIVE The allostasis theory states that, as addiction develops, alcohol is consumed to relieve negative affect rather than to produce positive effects. This study aimed to investigate the real-time subjective effects of alcohol in individuals with alcohol use disorder (AUD) and those prone to negative affect by virtue of having comorbid depressive disorder (DEP). METHODS Participants (N=221) completed
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Understanding the Effects of Combined Lisdexamfetamine and Cognitive Behavior Therapy for Adults With Binge Eating Disorder. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Tom Hildebrandt,Elizabeth Martin
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Using Genetically Diverse Rats to Identify Individual Differences in Addiction-Related Behaviors and Brain Activity. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Ginevra D'Ottavio,Kenichiro Negishi,Yavin Shaham
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Varenicline as a First-Line Treatment for Individuals With Current Major Depressive Disorder Who Smoke Cigarettes. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Andrea H Weinberger,Marc L Steinberg
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Correcting Overestimations in Self-Harm Visit Data. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Abid Rizvi
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Correcting Overestimations in Self-Harm Visit Data: Response From Bommersbach and Colleagues. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Tanner J Bommersbach,Mark Olfson,Taeho Greg Rhee
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A Fresh Look at the Allostasis Theory of Addiction. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-02-01 Markus Heilig
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Editorial: Disparities in Mental Health Care Access Prior to Youth Suicide: Implications for Research and Upstream Prevention. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-02-01 Holly C Wilcox,Taylor C Ryan,Alexandra Frosh
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Editorial: Unraveling the Mechanisms of Parenting Programs in Reducing Disruptive Behavior in Children. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-31 Xiaoning Sun
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Impact of the COVID-19 pandemic on self-harm and self-harm/suicide ideation: population wide, data linkage study and time series analysis: Commentary, Patra et al Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Bichitra Nanda Patra, Ananya Pant
The commentary raises important points like patients' actual availability of out- or in-patient services in the wake of pandemics and nationwide lockdowns. The focus is also drawn to missed opportunities to include data from hotlines and online services, a possible increase in death by suicides or changes in the factors that could add up to or protect a person from suicide.
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Synaptic vulnerability to amyloid-β and tau pathologies differentially disrupts emotional and memory neural circuits Mol. Psychiatry (IF 9.6) Pub Date : 2025-01-30 Maria Dolores Capilla-López, Angel Deprada, Yuniesky Andrade-Talavera, Irene Martínez-Gallego, Heriberto Coatl-Cuaya, Paula Sotillo, José Rodríguez-Alvarez, Antonio Rodríguez-Moreno, Arnaldo Parra-Damas, Carlos A. Saura
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The genetics of neurodegenerative diseases is the genetics of age-related damage clearance failure Mol. Psychiatry (IF 9.6) Pub Date : 2025-01-29 John Hardy, Valentina Escott-Price
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Genetic associations between orexin genes and phenotypes related to behavioral regulation in humans, including substance use Mol. Psychiatry (IF 9.6) Pub Date : 2025-01-29 Fazil Aliev, David De Sa Nogueira, Gary Aston-Jones, Danielle M. Dick
The hypothalamic neuropeptide system of orexin (hypocretin) neurons provides projections throughout the neuraxis and has been linked to sleep regulation, feeding and motivation for salient rewards including drugs of abuse. However, relatively little has been done to examine genes associated with orexin signaling and specific behavioral phenotypes in humans. Here, we tested for association of twenty-seven
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Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment Mol. Psychiatry (IF 9.6) Pub Date : 2025-01-29 Jacqueline Scholl, Priyanka Panchal, Natalie Nelissen, Lauren Z. Atkinson, Nils Kolling, Kate EA Saunders, John Geddes, Matthew FS Rushworth, Anna C. Nobre, Paul J. Harrison, Catherine J. Harmer
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Reflections: What Was It Like for Me: A Medical Student's Advocacy Experience at the AACAP Legislative Conference. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-30 Leonardo Lizbinski
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Editorial: Placebo Response in Child and Adolescent Psychiatry: To Mitigate or to Harness? J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-30 Manpreet K Singh
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Meet the JAACAP Journals Editorial Office Team. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-30 Justin Schreiber,Misty C Richards
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Alois Alzheimer and some of his lesser-known scientific contributions - Psychiatry in history. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Madhusudan Dalvi
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The dance of imperfection - Reflection. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Antonio Yaghy
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Prediction of suicidal behaviour as a three-body problem. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Philip J Batterham,Fiona Shand,Bridianne O'Dea
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Can liaison neurology add value to patient care within a mental health setting? Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 John H Ward,Brendan Sargent,Rob Bale,Johannes C Klein,Paul J Harrison,Belinda Lennox,Adam Al-Diwani,Adam E Handel
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Clozapine, relapse and adverse events: 10-year electronic cohort study in Canada: commentary, Kikuchi. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Yuki Kikuchi
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Clozapine, relapse, and adverse events: a 10-year electronic cohort study in Canada: commentary: author response. Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-30 Shawn Halayka,Lloyd Balbuena
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Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain Mol. Psychiatry (IF 9.6) Pub Date : 2025-01-29 Silas A. Buck, Samuel J. Mabry, Jill R. Glausier, Tabitha Banks-Tibbs, Caroline Ward, Jenesis Kozel, Chen Fu, Kenneth N. Fish, David A. Lewis, Ryan W. Logan, Zachary Freyberg
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Changes in Specialty Crisis Services Offered Before and After the Launch of the 988 Suicide and Crisis Lifeline JAMA Psychiatry (IF 22.5) Pub Date : 2025-01-29 Jonathan Cantor, Megan S. Schuler, Rose Kerber, Jonathan Purtle, Ryan K. McBain
ImportanceThe launch of the 988 Suicide and Crisis Lifeline (988) in July 2022 aimed to enhance access to crisis mental health services by replacing the National Suicide Prevention Lifeline with a more memorable number and expanding the Lifeline scope beyond suicide. However, 988’s success relies on the availability of community crisis services.ObjectiveTo examine whether the launch of 988 was associated
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Esketamine Treatment for Depression in Adults: A PRISMA Systematic Review and Meta-Analysis. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-01-29 Konstantinos N Fountoulakis,Athanasios Saitis,Alan F Schatzberg
OBJECTIVE Intranasal esketamine has been approved as an adjunctive therapy for treatment-resistant major depressive disorder with acute suicidal ideation and behavior. The authors conducted a systematic review and meta-analysis of the available data on its efficacy against depression and suicidality as well as its side effects. METHODS MEDLINE was searched with the keyword "esketamine" on March 24
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Spaced Transcranial Direct Current Stimulation for Major Depression. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-01-29 Maxime Couture,Véronique Desbeaumes Jodoin,Emma Bousseau,Arash Sarshoghi,Michael A Nitsche,Daniel M Blumberger,Chantal Bolduc,Cory R Weissman,Lawrence G Appelbaum,Zafiris J Daskalakis,Mohsen Poorganji,Paul Lespérance,Jean-Philippe Miron
OBJECTIVE This study investigated spaced transcranial direct current stimulation for major depressive disorder, focusing on feasibility. METHODS In a prospective open-label study, 30 participants with major depressive disorder were enrolled to receive a 50-session transcranial direct current stimulation (tDCS) treatment over 2 weeks. The feasibility, safety, tolerability, and preliminary therapeutic
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Randomized Controlled Trial of the Effects of High-Dose Ondansetron on Clinical Symptoms and Brain Connectivity in Obsessive-Compulsive and Tic Disorders. Am. J. Psychiatry (IF 15.1) Pub Date : 2025-01-29 Emily R Stern,Katherine A Collins,Laura B Bragdon,Goi Khia Eng,Nicolette Recchia,Barbara J Coffey,Evan Leibu,James W Murrough,Russell H Tobe,Dan V Iosifescu,Katherine E Burdick,Wayne K Goodman
OBJECTIVE Sensory phenomena (SP) are aversive sensations driving repetitive behaviors in obsessive-compulsive disorder (OCD) and Tourette's disorder that are not well addressed by standard treatments. SP are related to the functioning of an interoceptive-sensorimotor circuit that may be modulated by the 5-HT3 receptor antagonist ondansetron. The present study employed an experimental medicine approach
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Editorial: When the Kids at School Look Like Me: Who Benefits and in What Ways? J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-29 Gail A Edelsohn
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Editorial: Clinical Implications of Emotional Dysregulation Trajectories in Autism Spectrum Disorder. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-29 Ping-I Lin
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Editorial: Finding a Place in the Choir: A Clinical Perspective on Neurodiversity. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-29 Catherine Lord,Derica J Su
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Editorial: Cross-Cultural Assessment: Concepts, Methods, and Application. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-29 Andres J Pumariega
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Editorial: Grappling With the Relationships of Attention-Deficit/Hyperactivity Disorder and Obesity. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-29 L Eugene Arnold
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Evaluating Computerised Assessment of Motor Imitation (CAMI) for identifying autism-specific difficulties not observed for attention-deficit hyperactivity disorder or neurotypical development Br. J. Psychiatry (IF 8.7) Pub Date : 2025-01-28 Romila Santra, Carolina Pacheco, Deana Crocetti, René Vidal, Stewart H. Mostofsky, Bahar Tunçgenç
Background Reliable and specific biomarkers that can distinguish autism spectrum disorders (ASDs) from commonly co-occurring attention-deficit/hyperactivity disorder (ADHD) are lacking, causing misses and delays in diagnosis, and reducing access to interventions and quality of life.Aims To examine whether an innovative, brief (1-min), videogame method called Computerised Assessment of Motor Imitation
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Systematic Review and Individual Participant Data Meta-Analysis: Reducing Self-Harm in Adolescents: Pooled Treatment Effects, Study, Treatment and Participant Moderators. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-28 Alex Wright-Hughes,Amanda J Farrin,Peter Fonagy,Dennis Ougrin,Daniel Stahl,Judy Wright,Donna Irving,Faraz Mughal,Alex Truscott,Emma Diggins,Andrew Chanen,Emily Cooney,Greg Carter,Kerrie Clover,Mark Dadds,Guy Diamond,Christianne Esposito-Smythers,Jonathan Green,Helen Griffiths,Hossein Hassanian-Moghaddam,Simon Hatcher,Philip Hazell,Nusrat Husein,Michael Kaess,Cheryl King,Britt Morthorst,Rory C O'Connor
OBJECTIVE Self-harm is common in adolescents and a major public health concern. Evidence for effective interventions that stop repetition is lacking. This individual-participant-data (IPD) meta-analysis of randomised controlled trials (RCTs) aimed to provide robust estimates of therapeutic intervention effects and explore which treatments are best suited to different subgroups. METHOD We searched databases
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Associations Between Adolescents' Exposure to Online Racism and Substance Use. J. Am. Acad. Child Adolesc. Psychiatry (IF 9.2) Pub Date : 2025-01-28 Courtney B Dunn,Jasmine N Coleman,Phillip N Smith,Krista R Mehari
OBJECTIVE Adolescents' exposure to racism in online contexts is related to adverse outcomes, including poor mental health. This study aims to expand existing research by examining the unique relation between adolescents' online exposure to race-based violence and substance use, beyond experiences of racism in offline contexts, and by exploring racial differences. METHOD Data are from an observational
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Cognitive Impairment in Psychotic Disorders Is Associated with Brain Reductive Stress and Impaired Energy Metabolism as Measured by 31P Magnetic Resonance Spectroscopy Schizophr. Bull. (IF 5.3) Pub Date : 2025-01-27 Virginie-Anne Chouinard, Fei Du, Xi Chen, Emma Tusuzian, Boyu Ren, Jacey Anderson, Kyle Cuklanz, Wirya Feizi, Shuqin Zhou, Akila Weerasekera, Bruce M Cohen, Dost Öngür, Kathryn E Lewandowski
Background and Hypothesis Convergent evidence shows the presence of brain metabolic abnormalities in psychotic disorders. This study examined brain reductive stress and energy metabolism in people with psychotic disorders with impaired or average range cognition. We hypothesized that global cognitive impairment would be associated with greater brain metabolic dysregulation. Study Design Participants