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Gene – maltreatment interplay in adult ADHD symptoms: main role of a gene–environment correlation effect in a Brazilian population longitudinal study Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-14 Luciana Tovo-Rodrigues, Laísa Camerini, Thais Martins-Silva, Marina Xavier Carpena, Carolina Bonilla, Isabel Oliveira Oliveira, Cristiane Silvestre de Paula, Joseph Murray, Aluísio J. D. Barros, Iná S. Santos, Luis Augusto Rohde, Mara Helena Hutz, Julia Pasqualini Genro, Alicia Matijasevich
Childhood maltreatment correlates with attention-deficit/hyperactivity disorder (ADHD) in previous research. The interaction between ADHD genetic predisposition and maltreatment’s impact on ADHD symptom risk remains unclear. We aimed to elucidate this relationship by examining the interplay between a polygenic score for ADHD (ADHD-PGS) and childhood maltreatment in predicting ADHD symptoms during young
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Predicting patients with dementia most at risk of needing psychiatric in-patient or enhanced community care using routinely collected clinical data: retrospective multi-site cohort study Br. J. Psychiatry (IF 10.5) Pub Date : 2024-05-13 Sabina R. London, Shanquan Chen, Emad Sidhom, Jonathan R. Lewis, Emma Wolverson, Rudolf N. Cardinal, David Roalf, Christoph Mueller, Benjamin R. Underwood
Background Dementia is a common and progressive condition whose prevalence is growing worldwide. It is challenging for healthcare systems to provide continuity in clinical services for all patients from diagnosis to death.Aims To test whether individuals who are most likely to need enhanced care later in the disease course can be identified at the point of diagnosis, thus allowing the targeted intervention
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Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11.2 deletion female mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-13 Jun Ju, Xuanyi Li, Yifan Pan, Jun Du, Xinyi Yang, Siqi Men, Bo Liu, Zhenyu Zhang, Haolin Zhong, Jinyuan Mai, Yizheng Wang, Sheng-Tao Hou
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Reduction of APOE accounts for neurobehavioral deficits in fetal alcohol spectrum disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-11 Hye M. Hwang, Satoshi Yamashita, Yu Matsumoto, Mariko Ito, Alex Edwards, Junko Sasaki, Dipankar J. Dutta, Shahid Mohammad, Chiho Yamashita, Leah Wetherill, Tae-Hwi Schwantes-An, Marco Abreu, Amanda H. Mahnke, Sarah N. Mattson, Tatiana Foroud, Rajesh C. Miranda, Christina Chambers, Masaaki Torii, Kazue Hashimoto-Torii
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Occurrence and characteristics of suicidal ideation in psychiatrically healthy individuals based on ecological momentary assessment Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-10 Maria A. Oquendo, Hanga C. Galfalvy, Tse-Hwei Choo, Sarah Herzog, Ainsley K. Burke, M. Elizabeth Sublette, J. John Mann, Barbara H. Stanley
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Functional connectivity of the amygdala subnuclei in various mood states of bipolar disorder Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-09 Sidney Krystal, Laure Gracia, Camille Piguet, Chantal Henry, Mariana Alonso, Mircea Polosan, Julien Savatovsky, Josselin Houenou, Pauline Favre
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Real‐world effectiveness of antidepressants, antipsychotics and their combinations in the maintenance treatment of psychotic depression. Evidence from within‐subject analyses of two nationwide cohorts World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Heidi Taipale, Johannes Lieslehto, Markku Lähteenvuo, Aleksi Hamina, Antti Tanskanen, Ellenor Mittendorfer‐Rutz, Tapio Paljärvi, Marco Solmi, Andrea Cipriani, Christoph U. Correll, Jari Tiihonen
Psychotic depression (PD) is a severe mental disorder leading to functional disability and high risk of suicide, but very little is known about the comparative effectiveness of medications used in its maintenance treatment. The objective of this study was to investigate the comparative effectiveness of specific antipsychotics and antidepressants, and their combinations, on the risk of psychiatric hospitalization
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Another “and”: philosophy as glue World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Kenneth W.M. (Bill) Fulford
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The NIMH supports more comprehensive and inclusive genomic studies in psychiatry World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Miri Gitik, Lora A. Bingaman, Laura M. Rowland, Andrea Horvath Marques
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Absolute and relative outcomes of psychotherapies for eight mental disorders: a systematic review and meta‐analysis World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Pim Cuijpers, Clara Miguel, Marketa Ciharova, Mathias Harrer, Djordje Basic, Ioana A. Cristea, Nino de Ponti, Ellen Driessen, Jessica Hamblen, Sadie E. Larsen, Minoo Matbouriahi, Davide Papola, Darin Pauley, Constantin Y. Plessen, Rory A. Pfund, Kim Setkowski, Paula P. Schnurr, Wouter van Ballegooijen, Yingying Wang, Heleen Riper, Annemieke van Straten, Marit Sijbrandij, Toshi A. Furukawa, Eirini Karyotaki
Psychotherapies are first‐line treatments for most mental disorders, but their absolute outcomes (i.e., response and remission rates) are not well studied, despite the relevance of such information for health care users, providers and policy makers. We aimed to examine absolute and relative outcomes of psychotherapies across eight mental disorders: major depressive disorder (MDD), social anxiety disorder
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The future of dynamic networks in research and clinical practice World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Laura F. Bringmann
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The Serious Mental Illness Management System in China: concerns to be addressed World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Yi‐Lang Tang, Xiao‐Nian Luo, Xiang‐Dong Wang
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Being a strong voice for mental health parity, human rights, and community‐based psychiatric care in challenging times: developing the WPA Action Plan 2026‐2029 World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Thomas G. Schulze
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Philosophy of psychiatry: theoretical advances and clinical implications World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Dan J. Stein, Kris Nielsen, Anna Hartford, Anne‐Marie Gagné‐Julien, Shane Glackin, Karl Friston, Mario Maj, Peter Zachar, Awais Aftab
Work at the intersection of philosophy and psychiatry has an extensive and influential history, and has received increased attention recently, with the emergence of professional associations and a growing literature. In this paper, we review key advances in work on philosophy and psychiatry, and their related clinical implications. First, in understanding and categorizing mental disorder, both naturalist
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Medication use and sickness absence from work in bipolar disorder: a nationwide register‐based study World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Minna Holm, Antti Tanskanen, Jari Tiihonen, Heidi Taipale
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Philosophy of psychiatry can gain greater vitality by engaging the implications of new science World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Steven E. Hyman
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Algorithm‐based modular psychotherapy vs. cognitive‐behavioral therapy for patients with depression, psychiatric comorbidities and early trauma: a proof‐of‐concept randomized controlled trial World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Elisabeth Schramm, Moritz Elsaesser, Carolin Jenkner, Martin Hautzinger, Sabine C. Herpertz
Effect sizes of psychotherapies currently stagnate at a low‐to‐moderate level. Personalizing psychotherapy by algorithm‐based modular procedures promises improved outcomes, greater flexibility, and a better fit between research and practice. However, evidence for the feasibility and efficacy of modular‐based psychotherapy, using a personalized treatment algorithm, is lacking. This proof‐of‐concept
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Clinical translation of expert‐endorsed cognitive rehabilitation interventions for substance use disorders World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Antonio Verdejo‐Garcia, Jamie Berry, Alfonso Caracuel, Marc L. Copersino, Matt Field, Eric L. Garland, Valentina Lorenzetti, Leandro Malloy‐Diniz, Victoria Manning, Ely M. Marceau, David L. Pennington, Tara Rezapour, Justin C. Strickland, Reinout W. Wiers, Hamed Ekhtiari
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Modulating self‐referential processing through meditation and psychedelics: is scientific investigation of self‐transcendence clinically relevant? World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Matthew D. Sacchet, Maurizio Fava, Eric L. Garland
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Impact of air pollution and climate change on mental health outcomes: an umbrella review of global evidence World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Joaquim Radua, Michele De Prisco, Vincenzo Oliva, Giovanna Fico, Eduard Vieta, Paolo Fusar‐Poli
The impact of air pollution and climate change on mental health has recently raised strong concerns. However, a comprehensive overview analyzing the existing evidence while addressing relevant biases is lacking. This umbrella review systematically searched the PubMed/Medline, Scopus and PsycINFO databases (up to June 26, 2023) for any systematic review with meta‐analysis investigating the association
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Professionals in psychiatry need reflective competence World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Damiaan Denys
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The blueprint for advancing psychiatric education and scientific publications World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Norbert Skokauskas, Gary Chaimowitz, Dina Elgabry, Andrea Fiorillo, Anusha Lachman, Angeles Lopez Geist, Paul Robertson, Hee Jeong Yoo, Bennett Leventhal
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Improving the approach to LGBTQ persons in mental health care settings: a clinician's perspective World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Jack Drescher
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What's in a name? Mental disorders, mental health conditions and psychosocial disability World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Geoffrey M. Reed
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Standards for randomized controlled trials of efficacy of psychological treatments World Psychiatry (IF 73.3) Pub Date : 2024-05-10 David C. Mohr
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Hallucinating mice, psychotherapy in the brain, and computational psychiatry: the future of psychiatry is now World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Manfred Spitzer
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The lived experience of mental disorders in adolescents: a bottom‐up review co‐designed, co‐conducted and co‐written by experts by experience and academics World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Paolo Fusar‐Poli, Andrés Estradé, Cecilia M. Esposito, René Rosfort, Ilaria Basadonne, Milena Mancini, Giovanni Stanghellini, Jummy Otaiku, Oluwadamilola Olanrele, Lucas Allen, Muskan Lamba, Catherine Alaso, Judy Ieri, Margret Atieno, Yvonne Oluoch, Phides Ireri, Ephraim Tembo, Innocent Z. Phiri, Duncan Nkhoma, Noah Sichone, Candy Siadibbi, Pharidah R.I.O. Sundi, Nyathi Ntokozo, Laura Fusar‐Poli, Valentina
We provide here the first bottom‐up review of the lived experience of mental disorders in adolescents co‐designed, co‐conducted and co‐written by experts by experience and academics. We screened first‐person accounts within and outside the medical field, and discussed them in collaborative workshops involving numerous experts by experience – representing different genders, ethnic and cultural backgrounds
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The value and limitations of self‐administered questionnaires in clinical practice and epidemiological studies World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Mark Zimmerman
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Reflections on philosophy of psychiatry World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Kenneth S. Kendler
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Phenomenology, delusions and justice World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Matthew R. Broome
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From “online brains” to “online lives”: understanding the individualized impacts of Internet use across psychological, cognitive and social dimensions World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Joseph Firth, John Torous, José Francisco López‐Gil, Jake Linardon, Alyssa Milton, Jeffrey Lambert, Lee Smith, Ivan Jarić, Hannah Fabian, Davy Vancampfort, Henry Onyeaka, Felipe B. Schuch, Josh A. Firth
In response to the mass adoption and extensive usage of Internet‐enabled devices across the world, a major review published in this journal in 2019 examined the impact of Internet on human cognition, discussing the concepts and ideas behind the “online brain”. Since then, the online world has become further entwined with the fabric of society, and the extent to which we use such technologies has continued
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Report from the WPA Secretary for Scientific Sections World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Armen Soghoyan
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Achieving equality, inclusiveness, and cultural sensitivity in mental health (EDIT) World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Danuta Wasserman
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Report by the WPA Working Group on Developing Partnerships with Service Users and Family Carers (2020‐2023) World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Miia Männikkö, Guadalupe Morales Cano, Martha Savage, Charlene Sunkel, Afzal Javed, Roger M.K. Ng, Michaela Amering
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The aggregation of marginal gains: a pragmatic philosophy of clinical care in psychiatry World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Michael Berk, Wolfgang Marx, Andrew A. Nierenberg
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Five conceptual competences in psychiatry World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Miriam Solomon
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Anomalies of language in schizophrenia: a trajectory of mathematical and computational analyses World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Cheryl M. Corcoran, Guillermo A. Cecchi
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The promise of social recovery therapy in non‐affective psychoses World Psychiatry (IF 73.3) Pub Date : 2024-05-10 David Fowler
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Philosophy of psychiatry as study of paradigm changes World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Derek Bolton
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R. Spitzer and the depathologization of homosexuality: some considerations on the 50th anniversary World Psychiatry (IF 73.3) Pub Date : 2024-05-10 Jerome C. Wakefield
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Launching the social philosophy of psychiatry World Psychiatry (IF 73.3) Pub Date : 2024-05-10 John Z. Sadler
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The Complex Latent Structure of Attenuated Psychotic Symptoms: Hierarchical and Bifactor Models of SIPS Symptoms Replicated in Two Large Samples at Clinical High Risk for Psychosis Schizophr. Bull. (IF 6.6) Pub Date : 2024-05-10 Henry R Cowan, Trevor F Williams, Vijay A Mittal, Jean Addington, Carrie E Bearden, Kristin S Cadenhead, Tyrone D Cannon, Barbara A Cornblatt, Matcheri Keshevan, Diana O Perkins, Daniel H Mathalon, William Stone, Scott W Woods, Elaine F Walker
Background and Hypothesis The Structured Interview for Psychosis-Risk Syndromes (SIPS) and other assessments of psychosis risk define clinical high risk for psychosis (CHR) by the presence of attenuated psychotic symptoms. Despite extensive research on attenuated psychotic symptoms, substantial questions remain about their internal psychometric structure and relationships to comorbid non-psychotic
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Validation of an ICD-Code-Based Case Definition for Psychotic Illness Across Three Health Systems Schizophr. Bull. (IF 6.6) Pub Date : 2024-05-10 Anthony J Deo, Victor M Castro, Ashley Baker, Devon Carroll, Joseph Gonzalez-Heydrich, David C Henderson, Daphne J Holt, Kimberly Hook, Rakesh Karmacharya, Joshua L Roffman, Emily M Madsen, Eugene Song, William G Adams, Luisa Camacho, Sarah Gasman, Jada S Gibbs, Rebecca G Fortgang, Chris J Kennedy, Galina Lozinski, Daisy C Perez, Marina Wilson, Ben Y Reis, Jordan W Smoller
Background and Hypothesis Psychosis-associated diagnostic codes are increasingly being utilized as case definitions for electronic health record (EHR)-based algorithms to predict and detect psychosis. However, data on the validity of psychosis-related diagnostic codes is limited. We evaluated the positive predictive value (PPV) of International Classification of Diseases (ICD) codes for psychosis.
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Positive Reframing of Psychosis Risk Is Seen as More Beneficial and Less Harmful Than Negative Framing by Clinicians: An Experimental Videotaped Simulated Feedback Study Schizophr. Bull. (IF 6.6) Pub Date : 2024-05-10 Yamit Sol-Nottes, Shlomo Mendlovic, David Roe, Danny Koren
Background and Hypothesis Recent studies show that, despite providing some relief, feedback about being at risk for psychosis often triggers negative emotional reactions. Inspired by Tversky and Kahneman’s (1981) work on the framing effect and medical framings that favors positive framing like “life-threatening” over “high-risk for death,” this study tested the hypothesis that positive reframing of
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A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms Schizophr. Bull. (IF 6.6) Pub Date : 2024-05-10 Jessica Fattal, Maksim Giljen, Teresa Vargas, Katherine S F Damme, Monica E Calkins, Amy E Pinkham, Vijay A Mittal
Background and hypothesis Psychotic-like experiences (PLEs) are prevalent in the general population and, because they represent a lower end of the psychosis vulnerability spectrum, may be useful in informing mechanistic understanding. Although it is well-understood that motor signs characterize formal psychotic disorders, the developmental trajectory of these features and their relationships with PLEs
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Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-09 Jie Luo, Ling Li, Mingming Niu, Dehui Kong, Yi Jiang, Suresh Poudel, Annie W. Shieh, Lijun Cheng, Gina Giase, Kay Grennan, Kevin P. White, Chao Chen, Sidney H. Wang, Dalila Pinto, Yue Wang, Chunyu Liu, Junmin Peng, Xusheng Wang
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Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-08 Risako Fujikawa, Adam I. Ramsaran, Axel Guskjolen, Juan de la Parra, Yi Zou, Andrew J. Mocle, Sheena A. Josselyn, Paul W. Frankland
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Burden of Mental Disorders and Suicide Attributable to Childhood Maltreatment JAMA Psychiatry (IF 25.8) Pub Date : 2024-05-08 Lucinda Grummitt, Jessie R. Baldwin, Johanna Lafoa’i, Katherine M. Keyes, Emma L. Barrett
ImportanceThe proportion of mental disorders and burden causally attributable to childhood maltreatment is unknown.ObjectiveTo determine the contribution of child maltreatment to mental health conditions in Australia, accounting for genetic and environmental confounding.Design, Setting, and ParticipantsThis meta-analysis involved an epidemiological assessment accounting for genetic and environmental
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Role of Inflammation in Short Sleep Duration Across Childhood and Psychosis in Young Adulthood JAMA Psychiatry (IF 25.8) Pub Date : 2024-05-08 Isabel Morales-Muñoz, Steven Marwaha, Rachel Upthegrove, Vanessa Cropley
ImportanceShort sleep duration over a prolonged period in childhood could have a detrimental impact on long-term mental health, including the development of psychosis. Further, potential underlying mechanisms of these associations remain unknown.ObjectiveTo examine the association between persistent shorter nighttime sleep duration throughout childhood with psychotic experiences (PEs) and/or psychotic
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Estimated Number of Children Who Lost a Parent to Drug Overdose in the US From 2011 to 2021 JAMA Psychiatry (IF 25.8) Pub Date : 2024-05-08 Christopher M. Jones, Kun Zhang, Beth Han, Gery P. Guy, Jan Losby, Emily B. Einstein, Miriam Delphin-Rittmon, Nora D. Volkow, Wilson M. Compton
ImportanceParents’ overdose death can have a profound short- and long-term impact on their children, yet little is known about the number of children who have lost a parent to drug overdose in the US.ObjectiveTo estimate the number and rate of children who have lost a parent to drug overdose from 2011 to 2021 overall and by parental age, sex, and race and ethnicity.Design, Setting, and ParticipantsThis
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Towards the DSM-6: Results of a Survey of Experts on the Reintroduction of First-Rank Symptoms as Core Criteria of Schizophrenia and on Redefining Hallucinations Schizophr. Bull. (IF 6.6) Pub Date : 2024-05-08 Steffen Moritz, Lisa Borgmann, Andreas Heinz, Thomas Fuchs, Jürgen Gallinat
Background Diagnostic criteria for mental disorders are subject to change. This is particularly true for schizophrenia, whose diagnostic criteria in the current DSM-5 bear little resemblance to what Kraepelin once named “dementia praecox” and Bleuler termed “the schizophrenias.” The present study reports results from a survey of experts on two core topics of schizophrenia: (a) whether subsequent editions
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Interaction between mental disorders and social disconnectedness on mortality: a population-based cohort study Br. J. Psychiatry (IF 10.5) Pub Date : 2024-05-06 Lisbeth Mølgaard Laustsen, Linda Ejlskov, Danni Chen, Mathias Lasgaard, Jaimie L. Gradus, Søren Dinesen Østergaard, Marie Stjerne Grønkjær, Oleguer Plana-Ripoll
Background Despite the recognised importance of mental disorders and social disconnectedness for mortality, few studies have examined their co-occurrence.Aims To examine the interaction between mental disorders and three distinct aspects of social disconnectedness on mortality, while taking into account sex, age and characteristics of the mental disorder.Method This cohort study included participants
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A transdiagnostic prodrome for severe mental disorders: an electronic health record study Mol. Psychiatry (IF 11.0) Pub Date : 2024-05-06 Maite Arribas, Dominic Oliver, Rashmi Patel, Daisy Kornblum, Hitesh Shetty, Stefano Damiani, Kamil Krakowski, Umberto Provenzani, Daniel Stahl, Nikolaos Koutsouleris, Philip McGuire, Paolo Fusar-Poli
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Associations Between a Primary Care-Delivered Alcohol-Related Brief Intervention and Subsequent Opioid-Related Outcomes Am. J. Psychiatry (IF 17.7) Pub Date : 2024-05-06 Dan V. Blalock, Sophia A. Berlin, Theodore Berkowitz, Valerie A. Smith, Charles Wright, Rachel L. Bachrach, Janet M. Grubber
Objective: The co-occurrence of unhealthy alcohol use and opioid misuse is high and associated with increased rates of overdose, emergency health care utilization, and death. The current study examined whether receipt of an alcohol-related brief intervention is associated with reduced risk of negative downstream opioid-related outcomes. Methods: This retrospective cohort study included all VISN-6 Veterans
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Predictors of Substance Use Initiation by Early Adolescence Am. J. Psychiatry (IF 17.7) Pub Date : 2024-05-06 ReJoyce Green, Bethany J. Wolf, Andrew Chen, Anna E. Kirkland, Pamela L. Ferguson, Brittney D. Browning, Brittany E. Bryant, Rachel L. Tomko, Kevin M. Gray, Louise Mewton, Lindsay M. Squeglia
Objective: Substance use initiation during early adolescence is associated with later development of substance use and mental health disorders. This study used various domains to predict substance use initiation, defined as trying any nonprescribed substance (e.g., alcohol, tobacco, cannabis), by age 12, using a large longitudinal data set. Methods: Substance-naive youths from the Adolescent Brain
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Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences Am. J. Psychiatry (IF 17.7) Pub Date : 2024-05-06 Milena Radoman, Nia Fogelman, Cheryl Lacadie, Dongju Seo, Rajita Sinha
Objective: Stress and alcohol cue reactivity are associated with poor treatment outcomes in alcohol use disorder (AUD), but sex-specific neural correlates of stress and alcohol cue–induced craving compared with neutral cue–induced craving and of heavy drinking outcomes in AUD have not been examined. Thus, this study prospectively examined these associations and assessed sex differences. Methods: Treatment-seeking
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Topiramate Versus Naltrexone for Alcohol Use Disorder: A Genotype-Stratified Double-Blind Randomized Controlled Trial Am. J. Psychiatry (IF 17.7) Pub Date : 2024-05-06 Kirsten C. Morley, Henry R. Kranzler, Natasha Luquin, Nazila Jamshidi, Claire Adams, Mark Montebello, Chris Tremonti, Gezelle Dali, Warren Logge, Andrew Baillie, Maree Teesson, Ronald Trent, Paul S. Haber
Objective: There have been no well-controlled and well-powered comparative trials of topiramate with other pharmacotherapies for alcohol use disorder (AUD), such as naltrexone. Moreover, the literature is mixed on the effects of two polymorphisms—rs2832407 (in GRIK1) and rs1799971 (in OPRM1)—on response to topiramate and naltrexone, respectively. The authors sought to examine the comparative effectiveness
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Alcohol Use Disorder and Chronic Pain: An Overlooked Epidemic Am. J. Psychiatry (IF 17.7) Pub Date : 2024-05-06 Joao P. De Aquino, Matthew E. Sloan, Julio C. Nunes, Gabriel P. A. Costa, Jasmin L. Katz, Debora de Oliveira, Jocelyn Ra, Victor M. Tang, Ismene L. Petrakis
Alcohol use disorder (AUD) and chronic pain disorders are pervasive, multifaceted medical conditions that often co-occur. However, their comorbidity is often overlooked, despite its prevalence and clinical relevance. Individuals with AUD are more likely to experience chronic pain than the general population. Conversely, individuals with chronic pain commonly alleviate their pain with alcohol, which
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Understanding and Addressing Widening Racial Inequalities in Drug Overdose Am. J. Psychiatry (IF 17.7) Pub Date : 2024-05-06 Joseph R. Friedman, Max Jordan Nguemeni Tiako, Helena Hansen
The fourth wave of the United States overdose crisis—driven by the polysubstance use of fentanyl with stimulants and other synthetic substances—has driven sharply escalating racial/ethnic inequalities in drug overdose death rates. Here the authors present a detailed portrait of the latest overdose trends and synthesize the literature to describe where, how, and why these inequalities are worsening