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Are microglia in charge of controlling stress-response behavior? Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18
Chronic anxiety is a widespread mental health challenge that affects a considerable population worldwide [1]. From 2008 to 2018, anxiety significantly risen in the United States, especially in young adults aged 18–25. This particular age group has experienced the most significant increase, which was faster than other age groups [1]. Anxiety significantly impacts patients’ daily functioning, psychological
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Genetics of environmental sensitivity and its association with variations in emotional problems, autistic traits, and wellbeing Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Elham Assary, Olakunle A. Oginni, Genevieve Morneau-Vaillancourt, Georgina Krebs, Alicia J. Peel, Elisavet Palaiologou, Celestine Lockhart, Angelica Ronald, Thalia C. Eley
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Genetic overlap between Alzheimer’s disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Nitesh Enduru, Brisa S. Fernandes, Shahram Bahrami, Yulin Dai, Ole A. Andreassen, Zhongming Zhao
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Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Jiaxiang Wu, Jingliang Zhang, Xiaoling Chen, Kyle Wettschurack, Zhefu Que, Brody A. Deming, Maria I. Olivero-Acosta, Ningren Cui, Muriel Eaton, Yuanrui Zhao, Sophia M. Li, Matthew Suzuki, Ian Chen, Tiange Xiao, Manasi S. Halurkar, Purba Mandal, Chongli Yuan, Ranjie Xu, Wendy A. Koss, Dongshu Du, Fuxue Chen, Long-jun Wu, Yang Yang
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The impact of adult neurogenesis on affective functions: of mice and men Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Mariana Alonso, Anne-Cécile Petit, Pierre-Marie Lledo
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Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-18 Gerhard Leinenga, Xuan Vinh To, Liviu-Gabriel Bodea, Jumana Yousef, Gina Richter-Stretton, Tishila Palliyaguru, Antony Chicoteau, Laura Dagley, Fatima Nasrallah, Jürgen Götz
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Duration of Untreated Psychosis and Outcomes in First-Episode Psychosis: Systematic Review and Meta-analysis of Early Detection and Intervention Strategies Schizophr. Bull. (IF 6.6) Pub Date : 2024-03-16 Gonzalo Salazar de Pablo, Daniel Guinart, Alvaro Armendariz, Claudia Aymerich, Ana Catalan, Luis Alameda, Maria Rogdaki, Estrella Martinez Baringo, Joan Soler-Vidal, Dominic Oliver, Jose M Rubio, Celso Arango, John M Kane, Paolo Fusar-Poli, Christoph U Correll
Background The role of duration of untreated psychosis (DUP) as an early detection and intervention target to improve outcomes for individuals with first-episode psychosis is unknown. Study Design PRISMA/MOOSE-compliant systematic review to identify studies until February 1, 2023, with an intervention and a control group, reporting DUP in both groups. Random effects meta-analysis to evaluate (1) differences
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Association of neurotransmitter pathway polygenic risk with specific symptom profiles in psychosis Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-15 Tracy L. Warren, Justin D. Tubbs, Tyler A. Lesh, Mylena B. Corona, Sarvenaz S. Pakzad, Marina D. Albuquerque, Praveena Singh, Vanessa Zarubin, Sarah J. Morse, Pak Chung Sham, Cameron S. Carter, Alex S. Nord
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Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-15 Tim B. Bigdeli, Peter B. Barr, Nallakkandi Rajeevan, David P. Graham, Yuli Li, Jacquelyn L. Meyers, Bryan R. Gorman, Roseann E. Peterson, Frederick Sayward, Krishnan Radhakrishnan, Sundar Natarajan, David A. Nielsen, Anna V. Wilkinson, Anil K. Malhotra, Hongyu Zhao, Mary Brophy, Yunling Shi, Timothy J. O’Leary, Theresa Gleason, Ronald Przygodzki, Saiju Pyarajan, Sumitra Muralidhar, J. Michael Gaziano
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Developing an individualized treatment rule for Veterans with major depressive disorder using electronic health records Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 Nur Hani Zainal, Robert M. Bossarte, Sarah M. Gildea, Irving Hwang, Chris J. Kennedy, Howard Liu, Alex Luedtke, Brian P. Marx, Maria V. Petukhova, Edward P. Post, Eric L. Ross, Nancy A. Sampson, Erik Sverdrup, Brett Turner, Stefan Wager, Ronald C. Kessler
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Association of semaglutide with reduced incidence and relapse of cannabis use disorder in real-world populations: a retrospective cohort study Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 William Wang, Nora D. Volkow, Nathan A. Berger, Pamela B. Davis, David C. Kaelber, Rong Xu
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Early-life prefrontal cortex inhibition and early-life stress lead to long-lasting behavioral, transcriptional, and physiological impairments Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 Edênia C. Menezes, Heather Geiger, Fabiula F. Abreu, Lital Rachmany, Donald A. Wilson, Melissa J. Alldred, Francisco X. Castellanos, Rui Fu, Derya Sargin, André Corvelo, Cátia M. Teixeira
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Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 Pol Puigseslloses, Núria Nadal-Gratacós, Gabriel Ketsela, Nicola Weiss, Xavier Berzosa, Roger Estrada-Tejedor, Mohammad Nazmul Islam, Marion Holy, Marco Niello, David Pubill, Jordi Camarasa, Elena Escubedo, Harald H. Sitte, Raúl López-Arnau
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Neuron type-specific proteomics reveals distinct Shank3 proteoforms in iPSNs and dSPNs lead to striatal synaptopathy in Shank3B–/– mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-14 Yi-Zhi Wang, Tamara Perez-Rosello, Samuel N. Smukowski, D. James Surmeier, Jeffrey N. Savas
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Painful physical symptoms and antidepressant treatment outcome in depression: a systematic review and meta-analysis Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-13 Jia Jia Liu, Xiao Huang, Yan-Ping Bao, Lin Lu, Ping Dong, Owen M. Wolkowitz, John R. Kelsoe, Jie Shi, Ya Bin Wei
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Reciprocal Effects Between Negative Parenting and Children’s Callous-Unemotional Traits From Mid to Late Childhood Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Patrizia Pezzoli, Jean-Baptiste Pingault, Margherita Malanchini, Ivan Voronin, Eamon McCrory, Pasco Fearon, Essi Viding
Objective: The role of negative parenting in the development of callous-unemotional (CU) traits remains unclear. Both negative parenting and CU traits are influenced by genetic and environmental factors. The authors used genetically informed longitudinal cross-lagged models to examine the extent to which reciprocal effects between negative parenting and children’s CU traits in mid-to-late childhood
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Subcortico-Cortical Dysconnectivity in ADHD: A Voxel-Wise Mega-Analysis Across Multiple Cohorts Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Luke J. Norman, Gustavo Sudre, Jolie Price, Philip Shaw
Objective: A large body of functional MRI research has examined a potential role for subcortico-cortical loops in the pathogenesis of attention deficit hyperactivity disorder (ADHD), but has produced inconsistent findings. The authors performed a mega-analysis of six neuroimaging data sets to examine associations between ADHD diagnosis and traits and subcortico-cortical connectivity. Methods: Group
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Neuromelanin-Sensitive MRI as Candidate Marker for Treatment Resistance in First-Episode Schizophrenia Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Marieke van der Pluijm, Kenneth Wengler, Pascalle N. Reijers, Clifford M. Cassidy, Kaithlyn Tjong Tjin Joe, Olav R. de Peuter, Guillermo Horga, Jan Booij, Lieuwe de Haan, Elsmarieke van de Giessen
Objective: Markers for treatment resistance in schizophrenia are needed to reduce delays in effective treatment. Nigrostriatal hyperdopaminergic function plays a critical role in the pathology of schizophrenia, yet antipsychotic nonresponders do not show increased dopamine function. Neuromelanin-sensitive MRI (NM-MRI), which indirectly measures dopamine function in the substantia nigra, has potential
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Durability of Effects of Cognitive Remediation on Cognition and Psychosocial Functioning in Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Clinical Trials Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-13 Antonio Vita, Stefano Barlati, Anna Ceraso, Gabriele Nibbio, Francesca Durante, Michele Facchi, Giacomo Deste, Til Wykes
Objective: Cognitive remediation provides substantial improvements in cognitive performance and real-world functioning for people living with schizophrenia, but the durability of these benefits needs to be reassessed and better defined. The aims of this study were to provide a comprehensive assessment of the durability of the benefits of cognitive remediation for cognition and functioning in people
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Leanne Williams: fighting stigma through imaging Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Talha Burki
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A museum celebration of the mind Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Jessica Catchpole
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Mental health and support 1 year after the earthquakes in Türkiye Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Gulsah Kurt, Merve Erşahin, A Tamer Aker, Ersin Uygun, Ceren Acartürk
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The ethics of psychiatric management in times of disaster and war: experiences from Israel after the Oct 7 attack Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Rael D Strous, Yaakov Monovich
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Stigma: can we still do more to reduce it? Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Camila Chagas, José Carlos F Galduróz
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5-year mental health outcomes for children and adolescents presenting with psychiatric symptoms to general practitioners in England: a retrospective cohort study Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Morwenna Senior MBBS, Matthias Pierce PhD, Vicky P Taxiarchi PhD, Shruti Garg PhD, Prof Dawn Edge PhD, Tamsin Newlove-Delgado PhD, Sharon A S Neufeld PhD, Prof Kathryn M Abel PhD
Little information is available on the clinical trajectories of children and adolescents who attend general practice (GP) with psychiatric symptoms. We aimed to examine 5-year service use in English primary care for children and adolescents with neurodevelopmental or mental health symptoms or diagnoses. In this retrospective cohort study, we used anonymised primary care health records from the Clinical
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Heterogeneity of outcome measures in depression trials and the relevance of the content of outcome measures to patients: a systematic review Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-13 Christopher Veal MSc, Anneka Tomlinson MD PhD, Prof Andrea Cipriani MD PhD, Samuel Bulteau MD PhD, Prof Chantal Henry MD PhD, Chlöé Müh MSc, Suzanne Touboul PhD, Nikki De Waal MSc, Hana Levy-Soussan MSc, Prof Toshi A Furukawa MD, Eiko I Fried PhD, Prof Viet-Thi Tran MD PhD, Astrid Chevance MD PhD
Research waste occurs when randomised controlled trial (RCT) outcomes are heterogeneous or overlook domains that matter to patients (eg, relating to symptoms or functions). In this systematic review, we reviewed the outcome measures used in 450 RCTs of adult unipolar and bipolar depression registered between 2018 and 2022 and identified 388 different measures. 40% of the RCTs used the same measure
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Tonic NMDAR Currents in the Brain: Regulation and Cognitive Functions Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-13 Hayoung Kim, Sunyeong Choi, Euisun Lee, Wuhyun Koh, C. Justin Lee
Synaptically localized N-methyl-D-aspartate receptors (NMDARs) play a crucial role in important cognitive functions by mediating synaptic transmission and plasticity. In contrast, a tonic NMDAR current exists, thought to be mediated by extrasynaptic NMDARs, with a less clear function. This review provides a comprehensive overview of tonic NMDAR currents, focusing on their roles in synaptic transmission/plasticity
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Prefrontal regulation of social behavior and related deficits: insights from rodent studies Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-13 Nancy R. Mack, Nadia N. Bouras, Wen-Jun Gao
The prefrontal cortex (PFC) is well known as the executive center of the brain, combining internal states and goals to execute purposeful behavior, including social actions. With the advancement of tools for monitoring and manipulating neural activity in rodents, substantial progress has been made in understanding the specific cell types and neural circuits within the PFC that are essential for processing
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Reduced protein stability of 11 pathogenic missense STXBP1/MUNC18-1 variants and improved disease prediction Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-13 Timon André, Annemiek A. van Berkel, Gurdeep Singh, Esam T. Abualrous, Gaurav D. Diwan, Torsten Schmenger, Lara Braun, Jörg Malsam, Ruud F. Toonen, Christian Freund, Robert B. Russell, Matthijs Verhage, Thomas H. Söllner
Pathogenic variants in /Munc18-1 cause severe encephalopathies that are among the most common in genetic neurodevelopmental disorders. Different molecular disease mechanisms have been proposed and pathogenicity prediction is limited. This study aims to define a generalized disease concept for STXBP1-related disorders and improve prediction. A cohort of 11 disease-associated and five neutral variants
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Mental health at work: societal, economic and health imperatives align; it's time to act Br. J. Psychiatry (IF 10.5) Pub Date : 2024-03-12 Darren Minshall, Derek K. Tracy, Mark Tarn, Neil Greenberg
The enormous impact of mental illness on work and productivity is a global challenge, with immense costs to wider society. Now is the time for action, with new international guidelines and an emergent consensus on occupational mental healthcare. Alongside governments, organisations and employers, psychiatrists have a leading role to play.
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The experience of felt presence in a general population sample Br. J. Psychiatry (IF 10.5) Pub Date : 2024-03-12 Sanne G. Brederoo, Ben Alderson-Day, Janna N. de Boer, Mascha M. J. Linszen, Iris E. C. Sommer
Felt presence is a widely occurring experience, but remains under-recognised in clinical and research practice. To contribute to a wider recognition of the phenomenon, we aimed to assess the presentation of felt presence in a large population sample (n = 10 447) and explore its relation to key risk factors for psychosis. In our sample 1.6% reported experiencing felt presence in the past month. Felt
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Frontostriatal circuit dysfunction leads to cognitive inflexibility in neuroligin-3 R451C knockin mice Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-08 Shen Lin, Cui-ying Fan, Hao-ran Wang, Xiao-fan Li, Jia-li Zeng, Pei-xuan Lan, Hui-xian Li, Bin Zhang, Chun Hu, Junyu Xu, Jian-hong Luo
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Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-08 Ethan J. Goodman, Rebecca G. Biltz, Jonathan M. Packer, Damon J. DiSabato, Samuel P. Swanson, Braeden Oliver, Ning Quan, John F. Sheridan, Jonathan P. Godbout
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Glial-restricted precursors stimulate endogenous cytogenesis and effectively recover emotional deficits in a model of cytogenesis ablation Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-07 Joana Martins-Macedo, Bruna Araújo, Sandra I. Anjo, Tiago Silveira-Rosa, Patrícia Patrício, Nuno Dinis Alves, Joana M. Silva, Fábio G. Teixeira, Bruno Manadas, Ana J. Rodrigues, Angelo C. Lepore, António J. Salgado, Eduardo D. Gomes, Luísa Pinto
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Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-07 Kevin J. Clancy, Quentin Devignes, Boyu Ren, Yara Pollmann, Sienna R. Nielsen, Kristin Howell, Poornima Kumar, Emily L. Belleau, Isabelle M. Rosso
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Advancing understanding of the mechanisms of antipsychotic-associated cognitive impairment to minimise harm: a call to action Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-07 Kelly Allott, Sidhant Chopra, Jack Rogers, Maria Regina Dauvermann, Scott Richard Clark
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Vasopressin deficiency: a hypothesized driver of both social impairment and fluid imbalance in autism spectrum disorder Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-07 Lauren Clarke, Neil Gesundheit, Elliott H. Sherr, Antonio Y. Hardan, Karen J. Parker
Scientific naming conventions are often idiosyncratic. For example, biological processes have acquired names after a physician who described a syndrome (Alois Alzheimer), the resemblance of a structure to a common item (sella turcica or Turkish saddle), or a function a molecule is observed to mediate (growth hormone). Although these names may be useful for initial characterization, they can also create
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Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-07 George I. Papakostas, Madhukar H. Trivedi, Richard C. Shelton, Dan V. Iosifescu, Michael E. Thase, Manish K. Jha, Sanjay J. Mathew, Charles DeBattista, Mehmet E. Dokucu, Olga Brawman-Mintzer, Glenn W. Currier, William Vaughn McCall, Mandana Modirrousta, Matthew Macaluso, Alexander Bystritsky, Fidel Vila Rodriguez, Erik B. Nelson, Albert S. Yeung, Anna Feeney, Leslie C. MacGregor, Thomas Carmody, Maurizio
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Proteomic analysis of the developing mammalian brain links PCDH19 to the Wnt/β-catenin signalling pathway Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-07 Rebekah de Nys, Alison Gardner, Clare van Eyk, Stefka Mincheva-Tasheva, Paul Thomas, Rudrarup Bhattacharjee, Lachlan Jolly, Isabel Martinez-Garay, Ian W. J. Fox, Karthik Shantharam Kamath, Raman Kumar, Jozef Gecz
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PAK3 activation promotes the tangential to radial migration switch of cortical interneurons by increasing leading process dynamics and disrupting cell polarity Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-07 Lucie Viou, Melody Atkins, Véronique Rousseau, Pierre Launay, Justine Masson, Clarisse Pace, Fujio Murakami, Jean-Vianney Barnier, Christine Métin
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CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-07 Weinan Zhao, Yu-Mei Yu, Xiao-Yi Wang, Sun-Hui Xia, Yu Ma, Huimei Tang, Mingshu Tao, He Li, Zheng Xu, Jun-Xia Yang, Peng Wu, Hongxing Zhang, Hai-Lei Ding, Jun-Li Cao
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The complex etiology of autism spectrum disorder due to missense mutations of CHD8 Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-05 Taichi Shiraishi, Yuta Katayama, Masaaki Nishiyama, Hirotaka Shoji, Tsuyoshi Miyakawa, Taisuke Mizoo, Akinobu Matsumoto, Atsushi Hijikata, Tsuyoshi Shirai, Kouta Mayanagi, Keiichi I. Nakayama
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Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis Schizophr. Bull. (IF 6.6) Pub Date : 2024-03-07 Cassandra M J Wannan, Barnaby Nelson, Jean Addington, Kelly Allott, Alan Anticevic, Celso Arango, Justin T Baker, Carrie E Bearden, Tashrif Billah, Sylvain Bouix, Matthew R Broome, Kate Buccilli, Kristin S Cadenhead, Monica E Calkins, Tyrone D Cannon, Guillermo Cecci, Eric Yu Hai Chen, Kang Ik K Cho, Jimmy Choi, Scott R Clark, Michael J Coleman, Philippe Conus, Cheryl M Corcoran, Barbara A Cornblatt
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals
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A milestone in patient-centred care Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-06 Timur Liwinski, Christian G Huber, Undine E Lang
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Open-door policy versus treatment-as-usual in urban psychiatric inpatient wards: a pragmatic, randomised controlled, non-inferiority trial in Norway Lancet Psychiatry (IF 64.3) Pub Date : 2024-03-06 Anne-Marthe Rustad Indregard PhD, Hans Martin Nussle MS, Milada Hagen PhD, Per Olav Vandvik MD PhD, Martin Tesli MD PhD, Jakov Gather MD, Nikolaj Kunøe PhD
Open-door policy is a recommended framework to reduce coercion in psychiatric wards. However, existing observational data might not fully capture potential increases in harm and use of coercion associated with open-door policies. In this first randomised controlled trial, we compared coercive practices in open-door policy and treatment-as-usual wards in an urban hospital setting. We hypothesised that
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Irritability in Youths: A Critical Integrative Review Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-29 Ellen Leibenluft, Laura E. Allen, Robert R. Althoff, Melissa A. Brotman, Jeffrey D. Burke, Gabrielle A. Carlson, Daniel P. Dickstein, Lea R. Dougherty, Spencer C. Evans, Katharina Kircanski, Daniel N. Klein, Eleanor P. Malone, Carla A. Mazefsky, Joel Nigg, Susan B. Perlman, Daniel S. Pine, Amy Krain Roy, Giovanni A. Salum, Amy Shakeshaft, Jamilah Silver, Joel Stoddard, Anita Thapar, Wan-Ling Tseng
Irritability, defined as proneness to anger that may impair an individual’s functioning, is common in youths. There has been a recent upsurge in relevant research. The authors combine systematic and narrative review approaches to integrate the latest clinical and translational findings and provide suggestions for addressing research gaps. Clinicians and researchers should assess irritability routinely
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N2 Responses in Youths With Psychosis Risk Syndrome and Their Association With Clinical Outcomes: A Cohort Follow-Up Study Based on the Three-Stimulus Visual Oddball Paradigm Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-29 Yongqing Hou, Haishuo Xia, Tianbao He, Bohua Zhang, Guiping Qiu, Antao Chen
Objective: Schizophrenia often occurs during youth, and psychosis risk syndrome occurs before the onset of psychosis. The aim of this study was to determine whether the visual event-related potential responses in youths with psychosis risk syndrome were defective in the presence of interference stimuli and associated with their clinical outcomes. Methods: A total of 223 participants, including 122
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Current and Future Approaches to Pediatric Anxiety Disorder Treatment Am. J. Psychiatry (IF 17.7) Pub Date : 2024-03-01 Andre Zugman, Anderson M. Winkler, Purnima Qamar, Daniel S. Pine
This overview critically appraises the literature on the treatment of pediatric anxiety disorders. The two established treatments for these conditions comprise cognitive-behavioral therapy (CBT) and antidepressant medications. Many youths receiving these treatments fail to achieve remission, which creates a need for new treatments. After summarizing the literature on CBT and currently available medications
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Current and future applications of light-sheet imaging for identifying molecular and developmental processes in autism spectrum disorders Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-05 Amelie Soumier, Guillaume Lio, Caroline Demily
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Isolation of Distinct Networks Driving Action and Cognition in Psychomotor Processes Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-05 Alexandra B. Moussa-Tooks PhD, Adam Beermann MA, Karlos Manzanarez Felix BS, Michael Coleman MA, Sylvain Bouix PhD, Daphne Holt MD PhD, Kathryn E. Lewandowski PhD, Dost Öngür MD PhD, Alan Breier MD, Martha E. Shenton PhD, Stephan Heckers MD MSc, Sebastian Walther MD, Roscoe O. Brady Jr. MD PhD, Heather Burrell Ward MD
Psychomotor disturbances are observed across psychiatric disorders and often present as psychomotor slowing, agitation, disorganized behavior, or catatonia. Psychomotor function includes both cognitive and motor components, but the neural circuits driving these subprocesses and how they relate to symptoms have remained elusive for centuries. We analyzed data from the Human Connectome Project for Early
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Gene expression networks regulated by human personality Mol. Psychiatry (IF 11.0) Pub Date : 2024-03-04 Coral del Val, Elisa Díaz de la Guardia-Bolívar, Igor Zwir, Pashupati P. Mishra, Alberto Mesa, Ramiro Salas, Guillermo F. Poblete, Gabriel de Erausquin, Emma Raitoharju, Mika Kähönen, Olli Raitakari, Liisa Keltikangas-Järvinen, Terho Lehtimäki, Claude Robert Cloninger
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Medical assistance in dying for mental illness: a complex intervention requiring a correspondingly complex evaluation approach Br. J. Psychiatry (IF 10.5) Pub Date : 2024-03-04 Hamer Bastidas-Bilbao, David Castle, Mona Gupta, Vicky Stergiopoulos, Lisa D. Hawke
Medical assistance in dying for mental illness as a sole underlying medical condition (MAiD MI-SUMC) is a controversial and complex policy in terms of psychosocial and ethical medical practice implications. We discuss the status of MAiD MI-SUMC in Canada and argue for the use of the UK Medical Research Council's framework on complex interventions in programme evaluations of MAiD MI-SUMC. It is imperative
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Childhood Adversity and Incident Psychotic Experiences in Early Adulthood: Cognitive and Psychopathological Mediators Schizophr. Bull. (IF 6.6) Pub Date : 2024-03-04 Andrea P Cortes Hidalgo, Gemma Hammerton, Jon Heron, Koen Bolhuis, Paul Madley-Dowd, Henning Tiemeier, Marinus H van IJzendoorn, Stanley Zammit, Hannah J Jones
Background and Hypothesis Childhood adversity is often described as a potential cause of incident psychotic experiences, but the underlying mechanisms are not well understood. We aimed to examine the mediating role of cognitive and psychopathological factors in the relation between childhood adversity and incident psychotic experiences in early adulthood. Study Design We analyzed data from the Avon
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Treatment and Mortality Following Cancer Diagnosis Among People With Non-affective Psychotic Disorders in Ontario, Canada: A Retrospective Cohort Study Schizophr. Bull. (IF 6.6) Pub Date : 2024-03-03 Jared C Wootten, Lucie Richard, Melody Lam, Phillip S Blanchette, Marco Solmi, Kelly K Anderson
Background and Hypothesis People with psychotic disorders have a higher risk of mortality following cancer diagnosis, compared to people without psychosis. The extent to which this disparity is influenced by differences in cancer-related treatment is currently unknown. We hypothesized that, following a cancer diagnosis, people with psychotic disorders were less likely to receive treatment and were
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Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-29 Soonjo Hwang, Ji-Woo Suk, Harma Meffert, Arica Lerdahl, William F. Garvey, Ryan Edwards, Alison Delizza, Brigette Soltis-Vaughan, Katrina Cordts, Ellen Leibenluft, R.J.R. Blair
Objective: The authors investigated the neural impact of intranasal oxytocin on emotion processing areas in youths with severe irritability in the context of disruptive mood and behavior disorders. Methods: Fifty-two participants with severe irritability, as measured by a score ≥4 on the Affective Reactivity Index (ARI), with diagnoses of disruptive behavior disorders (DBDs) and/or disruptive mood
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The causal relationship between gut microbiota, brain volume, and intelligence: a two-step Mendelian randomization analysis Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-01 Shi Yao, Ji-Zhou Han, Jing Guo, Xin Wang, Long Qian, Hao Wu, Wei Shi, Ren-Jie Zhu, Jia-Hao Wang, Shan-Shan Dong, Li-Li Cui, Yan Wang, Yan Guo, Tie-Lin Yang
Growing evidence indicates that dynamic changes in gut microbiome can affect intelligence; however, whether these relationships are causal remains elusive. We aimed to disentangle the poorly understood causal relationship between gut microbiota and intelligence. We performed a two-sample Mendelian randomization (MR) analysis using genetic variants from the largest available genome-wide association
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Prefrontal-Limbic Circuitry is Associated with Reward Sensitivity in Nonhuman Primates Biol. Psychiatry (IF 10.6) Pub Date : 2024-03-01 Kwang-Hyun Hur, Steven L. Meisler, Walid Yassin, Blaise B. Frederick, Stephen J. Kohut
Abnormal reward sensitivity is a risk factor for psychiatric disorders, including eating disorders such as overeating and binge-eating disorder, but the brain structural mechanisms underlying it are not completely understood. Here, we sought to investigate the relationship between multi-modal whole-brain structural features and reward sensitivity in nonhuman primates. Reward sensitivity was evaluated
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Perception of social inclusion/exclusion and response inhibition in adolescents with past suicide attempt: a multidomain task-based fMRI study Mol. Psychiatry (IF 11.0) Pub Date : 2024-02-29 Anthony J. Gifuni, Fabricio Pereira, M. Mallar Chakravarty, Martin Lepage, Henri W. Chase, Marie-Claude Geoffroy, Eric Lacourse, Mary L. Phillips, Gustavo Turecki, Johanne Renaud, Fabrice Jollant
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Pattern of Risks for Psychiatric and Substance Use Disorders in the Offspring of Parents With Alcohol Use Disorder Am. J. Psychiatry (IF 17.7) Pub Date : 2024-02-29 Kenneth S. Kendler, Linda Abrahamsson, Jan Sundquist, Kristina Sundquist
Objective: The authors sought to clarify the components of the familial liability to alcohol use disorder (AUD) by examining parent-offspring transmission in a large Swedish population sample. Methods: To this end, 1,244,516 offspring in intact families with a mean age at follow-up of 37.7 years (SD=6.8) were examined. Hazard ratios for offspring of parents with AUD were calculated using Cox models