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Preoxygenation strategies for endotracheal intubation in resource-limited settings: reframing the basics Crit. Care (IF 9.3) Pub Date : 2025-06-23 Dai Quang Huynh, Ngan Hoang Kim Trieu, Thao Thi Ngoc Pham
Endotracheal Intubation (ETI) is a common procedure in the emergency department and intensive care units (ICUs). In contrast to elective surgical patients, critically ill patients often face acute hypoxemic events related to underlying pulmonary pathology, elevated metabolic demands, impaired respiratory drive, obesity, or an inability to protect the airway from aspiration. Nearly half of emergency
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Advanced serial analysis of the diaphragm surface EMG: insights into the effect of pressure support on the neuro-ventilatory response during the ICU stay Crit. Care (IF 9.3) Pub Date : 2025-06-23 R. S. P. Warnaar, A. D. Cornet, A. Beishuizen, D. W. Donker, E. Oppersma
Ventilatory support levels in ICU patients should be tailored to both optimal gas exchange and respiratory muscle loading, as over- and underassistance may cause diaphragm dysfunction. The diaphragm’s capacity to overcome mechanical load and deliver ventilatory output is reflected by the patient’s neural respiratory drive (NRD), tidal volume (TV) and respiratory rate (RR). Surface electromyography
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Effect of technology-based acceptance and commitment therapy for smoking cessation: A systematic review and meta-analysis Int. J. Nurs. Stud. (IF 7.1) Pub Date : 2025-06-21 Xueqin Xia, Chen Gong, Yuanyuan Li, Lin Yin, Quan Yang, Xiaoyuan Zhang, Limei Liao
Tobacco use remains one of the world's greatest public health challenges, contributing substantially to morbidity and mortality. Effective and accessible smoking cessation interventions are essential to reducing tobacco-related health risks. Acceptance and Commitment Therapy (ACT) has demonstrated efficacy in enhancing quit rates. However, the effectiveness of technology-based ACT, a more accessible
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Critical care illness in allogeneic hematopoietic stem-cell transplantation recipients with chronic graft versus host disease Crit. Care (IF 9.3) Pub Date : 2025-06-20 Dara Chean, Romy Younan, Thibault Dupont, Emmanuel Canet, Anne-Sophie Moreau, Muriel Picard, Djamel Mokart, Laura Platon, Julien Mayaux, Florent Wallet, Nahema Issa, Jean-Herlé Raphalen, Frédéric Pène, Anne Renault, Régis Peffault de Latour, Naike Bigé, Elie Azoulay, Antoine Lafarge
Chronic graft-versus-host disease (cGVHD) is a leading long-term complication following allogeneic hematopoietic stem-cell transplantation (Allo-HSCT). However, its impact on outcomes in critically ill Allo-HSCT recipients has little been evaluated. We conducted a post hoc analysis of a multicenter cohort study involving Allo-HSCT recipients admitted to 14 French intensive care units (ICUs) between
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Tocilizumab in improving the hemodynamics of septic children with vasoplegia shock Crit. Care (IF 9.3) Pub Date : 2025-06-20 En‑Pei Lee, Jainn-Jim Lin, Shih‑Hsiang Chen, Han‑Ping Wu
Sepsis remains a leading cause of pediatric morbidity and mortality worldwide. Septic shock, a progression of sepsis characterized by profound cardiovascular dysfunction, carries mortality rates as high as 40–80% and often results in long-term neurocognitive deficits. In patients with septic shock, vasoplegia is the worse presentation of hemodynamics which related higher mortality. Vasoplegia is an
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The effects of extracorporeal blood purification (oXiris®) in patients with cardiogenic shock who require VA-ECMO (CLEAN ECMO): a prospective, open-label, randomized controlled pilot study Crit. Care (IF 9.3) Pub Date : 2025-06-20 Ryoung-Eun Ko, Ki Hong Choi, Kyungho Lee, Junseok Jeon, Hye Ryoun Jang, Chi Ryang Chung, Yang Hyun Cho, Taek Kyu Park, Joo Myung Lee, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Jeong Hoon Yang
A systemic inflammatory response can contribute to poor outcomes in an advanced stage of cardiogenic shock (CS). We investigated the efficacy of extracorporeal endotoxin and cytokine adsorption using oXiris in patients with CS undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO). In this prospective, single-center, randomized, open-label pilot trial, 40 patients with CS who were undergoing
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The Landscape of lower respiratory tract herpesviruses in severe pneumonia patients: a multicenter, retrospective study with prospective validation Crit. Care (IF 8.8) Pub Date : 2025-06-20 Fengqi Liu, Yiqi Zhuang, Xiaohan Huang, Laurent Papazian, Hongliu Cai, Huanzhang Shao, Qiong Chen, Chao Xie, Kankai Tang, KangChen Li, Mingqiang Wang, Yinghe Xu, Peng Shen, Qianqian Wang, Xuwei He, Nan Wang, Hongyu Wang, Muhua Dai, Yonghui Xiong, Lin Zhong, Yujie Pan, Lihong Chu, Bin Yang, Gensheng Zhang, Hua Zhou, Jinfu Xu, Chao Jiang, Lingtong Huang
Herpesviruses are widely distributed in the lower respiratory tract, yet no study has comprehensively characterized their clinical features and prognostic impact in severe pneumonia. In this multicenter, retrospective study, we included severe pneumonia patients who underwent bronchoalveolar lavage fluid (BALF) metagenomic testing in intensive care units across 17 medical centers from January 2019
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Organizational return on investment in nursing: A systematic review Int. J. Nurs. Stud. (IF 7.1) Pub Date : 2025-06-20 Olga Yakusheva, Kathryn Lee, Alissa V. Fial, Marianne E. Weiss
High-quality nursing care is crucial for healthcare quality and safety, yet there's limited understanding of the business case for investing in nursing from an organizational perspective. This study seeks to address this evidence gap by identifying and synthesizing data on the organizational return on investment from nursing human capital, considering initial investment costs and the resulting impact
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Experiences of Irish Mentors and Mentees Engaged in a National Nursing and Midwifery Mentorship Programme: Mixed Methods Study With a Qualitative Focus on Mentors' Views J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-20 Martina Giltenane, Louise Murphy, Anna Chatzi, Claire Mcnamara, Lorelli Nowell, Marie Kilduff, Aoife Lane, Margaret Williams, Owen Doody
AimTo gain an understanding of the experiences of mentors and mentees engaging in a national mentoring programme within nursing and midwifery in Ireland.DesignA two‐phased convergent parallel mixed methods study was undertaken.MethodsThe first phase was a quantitative non‐experimental descriptive study using an online survey with mentors (n = 12) and mentees (n = 6). The second phase was a qualitative
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Evaluation of Work‐Related Stress, Moral Reward and Job Satisfaction Among Healthcare Professionals in the Postpandemic Era J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-20 Αngeliki Fydanidou, Ourania S. Kotsiou
AimThis study investigates work‐related stress, moral reward and job satisfaction among healthcare professionals in the postpandemic era, focusing on the psychological and professional challenges they face. The study examines the role of excessive demands, inadequate support and reward imbalances, and explores the impact on healthcare workers' well‐being and patient care quality.DesignUtilising a quantitative
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Barriers and Facilitators to Cognitive Function Interventions in Rural Diabetic Older Adults: Using the COM‐B Model and Theoretical Domains Framework J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-20 Xueyan Liu, Jie Zhang, Xiangyun Guan, Yingjuan Cao
AimsWe aimed to identify the barriers and facilitators to participation in interventions aimed at improving cognitive function among older adults with type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI) in rural areas.DesignThis study is the qualitative phase of a larger randomised controlled trial and employs a descriptive approach.MethodsWe conducted in‐depth, semi‐structured face‐to‐face
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Decent Work Perception and Its Relationship With Work‐Related Flow and Psychological Capital Among Nurses: A Cross‐Sectional Study J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-20 Na Zheng, Teng Zhang, Xi‐fei He, Xiu‐qin Zhu
AimTo examine nurses' perceptions of decent work (defined by the ILO as safe, fair and socially recognised employment) and its relationship with work‐related flow and psychological capital.DesignA cross‐sectional survey design.MethodsIn 2023, we used convenient sampling to select 1930 nurses from 20 high‐grade A hospitals. A general data questionnaire, decent work perception scale (DWPS), work‐related
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Cardiovascular Prevention and Rehabilitation for Ischaemic Non‐Obstructive Coronary Artery Disease: Implementation Considerations From a Survey of UK Health Professionals J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-20 Simon Nichols, Susan Dawkes, Aynsley Cowie, Sarah Brown, Colin Berry, Helen Humphreys
AimsInvestigate if UK healthcare professionals have the resources and knowledge to provide cardiovascular prevention and rehabilitation to people with ischaemic non‐obstructive coronary artery disease (INOCA), and explore what type of care healthcare professionals believe patients should receive.DesignElectronic cross‐sectional survey of UK healthcare professionals, circulated between 7 January and
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Can we predict the future of respiratory failure prediction? Crit. Care (IF 9.3) Pub Date : 2025-06-19 Alex K. Pearce, Shamim Nemati, Ewan C. Goligher, Catherine L. Hough, Andre L. Holder, Gabriel Wardi, Philip Yang, Aaron Boussina, Patrick G. Lyons, Sarina Sahetya, Atul Malhotra, Angela Rogers
Mortality in patients with acute respiratory failure remains high. Predicting progression of acute respiratory failure may be critical to improving patient outcomes. Machine learning, a subset of artificial intelligence is a rapidly expanding area, which is being integrated into several areas of clinical medicine. This manuscript will address the knowledge gap in predicting the onset and progression
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Association of epinephrine and outcome in cardiac arrest with refractory shockable rhythm: a population-based, propensity-score matched analysis Crit. Care (IF 9.3) Pub Date : 2025-06-19 Lucie Fanet, François Javaudin, Florence Dumas, Frankie Beganton, Jean-Philippe Empana, Lionel Lamhaut, Daniel Jost, Eloi Marijon, Xavier Jouven, Alain Cariou, Wulfran Bougouin
Epinephrine use in cardiac arrest is increasingly controversial, with contrasting results according to initial rhythm. We assessed the association between epinephrine use and favorable neurological outcome among patients with out of hospital cardiac arrest with refractory shockable arrest. In this multicentric population-based prospective registry, we included all patients with out-of-hospital cardiac
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What is the optimal approach to analyse ventilator-free days? A simulation study Crit. Care (IF 9.3) Pub Date : 2025-06-19 Laurent Renard Triché, Matthieu Jabaudon, Nicolas Molinari, Jean-Marie Forel, Jean-Michel Constantin, Bruno Pereira, Sylvie Chevret
Ventilator-free days (VFDs) are a composite outcome in critical care research, reflecting both survival and mechanical ventilation duration. However, analysis methods for VFDs are inconsistent, with some focusing on counts and others on time-to-event outcomes, while other approaches such as the multistate model and the win ratio have emerged. We aimed to evaluate various statistical models through
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Bayesian reanalysis reinforces the potential mortality benefit of TNF-α inhibitors in COVID-19: a methodological perspective Crit. Care (IF 9.3) Pub Date : 2025-06-19 Jia-Jin Chen, Pei‑Chun Lai, Yen-Ta Huang
Dear Editor, Five and a half years since its emergence, despite widespread vaccination efforts, COVID-19 has not disappeared due to viral evolution similar to influenza virus variants, with recurrent sporadic outbreaks occurring in many regions, cities, and countries. Consequently, intensivists worldwide continue to face severe cases, making it crucial to synthesize evidence for managing critically
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Can we reliably use pulse pressure as a surrogate for stroke volume? Physiological background and potential clinical implications for shock resuscitation Crit. Care (IF 9.3) Pub Date : 2025-06-19 Zbigniew Putowski, Jean-Louis Teboul, Ricardo Castro, Denis Chemla, Jonatan Oras, Sebastian Morales, Eduardo Kattan, Glenn Hernandez
In critically ill patients, early hemodynamic assessment is essential for guiding shock resuscitation. While cardiac output (CO) is a key indicator of circulatory status, its measurement is often limited by technical and practical constraints. This perspective explores the physiological and clinical relevance of pulse pressure (PP) as a potential surrogate for stroke volume (SV), emphasizing its accessibility
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Muscle weakness after critical illness: unravelling biological mechanisms and clinical hurdles Crit. Care (IF 8.8) Pub Date : 2025-06-17 Alexandre Pierre, Raphael Favory, Claire Bourel, Michael Howsam, Raphael Romien, Steve Lancel, Sebastien Preau
Survivors of intensive care unit (ICU) are increasingly numerous because of better hospital care. However, several consequences of an ICU stay, known as post-intensive care syndrome, worsen long-term prognoses. A predominant feature in survivors is reduced muscle strength, mass, and physical function. This leads to lower exercise capacity, long-lasting physical disability, higher mortality risk, and
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What's your diagnosis? Pneumonia, splenic and subcutaneous abscesses. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-18 Hailong Li,Li Zhao,Ying Wang,Long Xiang
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Peer support strategies for newly qualified nurses: A systematic review Int. J. Nurs. Stud. (IF 7.1) Pub Date : 2025-06-18 Lorraine Raqueno, Monica Rückholdt, Dorothy W. Ndwiga, Meena Gupta, Toby Raeburn
Retention of newly qualified nurses is a challenge for health services worldwide. Graduate transition programs tend to provide top-down approaches that enlist senior nurses to mentor and train newly qualified nurses. Although peer support between newly qualified nurses has been shown to improve their experiences, existing studies mainly focus on support provided by senior nurses. Strategies focused
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Identifying critical intervention, contextual and implementation features in systematic reviews: intervention component analysis ten years on Int. J. Nurs. Stud. (IF 7.1) Pub Date : 2025-06-18 Katy Sutcliffe, Dylan Kneale
It is now widely recognised that in addition to providing robust evidence about intervention effectiveness, systematic reviews need to provide decision-makers with information about critical intervention, contextual and implementation features that support successful outcomes. Our 2015 paper introduced Intervention Component Analysis (ICA), a method comprised of three key approaches for examining trials
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Digital Healthcare and the Illusion of Progress J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-18 Brendan McCormack
We live in a post-humanist world, where the lines are blurred between human and non-human persons. We are in this space where the human and non-human, are all intersecting and creating overlaps that are no longer clearly defined. Posthumanism has existed for a very long time, through indigenous cultures where the earth, the land, trees and waters are treated with the same respect and criteria as those
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‘We've Taken on a More Advanced Clinical Role’: A Multimethod Study of Community Nurses' Extended Roles in Palliative Care J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-18 Ben Bowers, Kristian Pollock, Simon Etkind, Alison Leary, Stephen Barclay, Louisa Polak
AimTo explore community nurses' experiences of changes to their roles in palliative and end‐of‐life care.DesignAn e‐survey was followed by focus groups.MethodsFifty‐one community nurses with recent experience of delivering end‐of‐life care in the United Kingdom completed a survey about changes to their roles. A purposive sample of 35 respondents participated in focus groups exploring these changes
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Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial Crit. Care (IF 8.8) Pub Date : 2025-06-17 Ameldina Ceric, Josef Dankiewicz, Tobias Cronberg, Joachim Düring, Marion Moseby-Knappe, Martin Annborn, Teresa L. May, Matthew Thomas, Anders Morten Grejs, Christian Rylander, Jan Belohlavek, Pedro Wendel-Garcia, Matthias Haenggi, Claudia Schrag, Matthias P. Hilty, Thomas R. Keeble, Matt P. Wise, Paul Young, Fabio Silvio Taccone, Chiara Robba, Alain Cariou, Glenn Eastwood, Manoj Saxena, Susann Ullén
The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening. This was a post hoc analysis of the TTM2-trial, which randomized 1900
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Optimizing microbiological surveillance during selective digestive decontamination in the intensive care unit: an in silico simulation study Crit. Care (IF 8.8) Pub Date : 2025-06-17 Jelle L. G. Haitsma Mulier, Fleur J. van Dijk, Valentijn A. Schweitzer, Marc J. M. Bonten, Lennie P. G. Derde, Olaf L. Cremer
Selective Digestive Decontamination (SDD) prevents infections and reduces mortality in the intensive care unit (ICU). Microbiological surveillance is considered essential for effective decontamination and detecting antibiotic resistance. However, its optimal frequency is unclear. We compared microbiological yield and costs of different surveillance intervals during SDD. In a computational simulation
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Methodological considerations regarding cardiac arrest studies in hyperoxemia meta-analysis Crit. Care (IF 8.8) Pub Date : 2025-06-17 Akihiro Sakai, Junichi Izawa
Dear Editor, We read with great interest the study by Romero-Garcia et al. titled “Neurological outcomes and mortality following hyperoxemia in adult patients with acute brain injury: an updated meta-analysis and meta-regression” [1]. The analysis regarding oxygen concentration and neurological outcomes was particularly compelling. However, we would like to highlight a point regarding the cardiac arrest
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Post-extubation dysphagia in the ICU−a narrative review: epidemiology, mechanisms and clinical management (Update 2025) Crit. Care (IF 8.8) Pub Date : 2025-06-16 Daniela Bertschi, Francesco Rotondo, Jan Waskowski, Philipp Venetz, Carmen A. Pfortmueller, Joerg C. Schefold
Dysphagia (i.e. an impairment in swallowing function that impacts on safety or efficiency) is present in many intensive care unit (ICU) survivors, in particular following extubation (“post-extubation dysphagia”, PED). Despite the fact that pathomechanisms leading to PED are currently incompletely understood, local as well as central neurological and neuromuscular dysfunctions may be key to development
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Reckoning With Racism in Nursing: Towards Structural Transformation and Epistemic Justice J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-17 Agness Chisanga Tembo, Calvin Moorley
Despite longstanding rhetorical commitments to diversity, equity and inclusion, racism remains a pervasive and a systemic force within the nursing profession, shaping experiences of both the workforce and the populations they serve. A recent UK survey found that 75% of nurses from ethnic minority backgrounds reported experiencing racial discrimination from colleagues or patients, resulting in stress
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Dysphagia in Head and Neck Cancer Patients: A Qualitative Meta‐Synthesis of Patient and Caregiver Experiences and Perspectives J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-17 Yu Zhang, Yiqiao Wang, Wenjie Xu, Zeling Zhang, Yu Zhu, Hongwei Wan
BackgroundDysphagia not only affects the nutritional intake of head and neck cancer (HNC) patients but may also lead to social avoidance, emotional fluctuations, and a decline in life confidence. Furthermore, dysphagia places an additional psychological and physical burden on caregivers, significantly altering their lifestyles.MethodThis study employed a qualitative systematic review approach to comprehensively
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Successful Retention Strategies for Nurses in Home Visiting Nursing Services: A Scoping Review J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-17 Vari M. Drennan, Joel Coll Ferrer, Claire Thurgate, Lihua Wu, Mary Halter, Erkan Alkan
AimTo identify successful strategies and underpinning mechanisms for retaining nurses in home visiting nursing services.DesignScoping review.Data SourcesMEDLINE, CINAHL, Google Scholar, Theses Global Databases (1 January 2000 to 23 November 2023); international nursing organisations websites (January–April 2024).Review MethodsThe methods followed the Joanna Briggs Institute guidance. Two researchers
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How Classmates Experience Visiting Their Hospitalised Peer During Cancer Treatment: A RESPECT Study J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-17 Natasha Nybro Boensvang, Martin Kaj Fridh, Claire Elizabeth Wakefield, Pernille Envold Bidstrup, Hanne Bækgaard Larsen
AimTo explore how classmate ‘ambassadors’ experienced and engaged in social interaction while visiting a hospitalised peer undergoing cancer treatment.DesignA phenomenological‐hermeneutic inspired exploratory study.MethodsUsing on‐the‐go semi‐structured interviews and participant observations from January to December 2023 in Denmark, we included 27 school‐aged ambassadors aged 6–18 years old; 18 participated
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‘When I Migrated, I Faced Challenges but Gained Much More…’ Challenges and Support Needs of Internationally Educated Nurses—A Qualitative Study J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-17 Turgay Yalcinkaya, Erkan Ünsal
AimThis study aims to examine the experiences and support needs of internationally educated nurses (IENs) who migrated from Türkiye to different countries.BackgroundWith the impact of globalisation and changes in the healthcare sector, the migration of IENs is on the rise. The global shortage of nurses has prompted high‐income countries to increase their recruitment of nurses from low‐ and middle‐income
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The Effect of Holistic and Humanistic Approach on Professional Pride in Nursing Care J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-17 Sebahat Kuşlu, Ayşe Eminoğlu, Mina Muşluoğlu
AimThis study examines the effect of nurses' holistic nursing competency levels and humanistic behaviour skills on their professional pride levels.DesignThe study was designed as a cross‐sectional study.MethodsThe sample consisted of 224 nurses working in a city hospital. The data were collected using the Personal Information Form, the Holistic Nursing Competence Scale, the Humanistic Behaviour Skill
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How Does Mentorship Influence Doctoral Nursing Education? An Integrative Review J. Adv. Nurs. (IF 3.4) Pub Date : 2025-06-17 Adrianna L. Watson, Carmel Bond, Helen Aveyard, Graeme D. Smith, Debra Jackson
AimTo report how mentorship influences the educational experiences and training of doctoral nursing students.DesignIntegrative literature review.MethodsPeer‐reviewed journal articles, theoretical works and editorials published in English that focused on doctoral nursing education were included. Papers reporting on mentorship for undergraduate nursing students, nursing faculty, educators, academics
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Setting the record straight: revisiting the debate on extracorporeal therapies in sepsis Crit. Care (IF 8.8) Pub Date : 2025-06-16 Klaus Stahl, Pedro David Wendel Garcia, Christian Bode, Sascha David
Dear editor, We find ourselves grappling with certain aspects of Gabriella Bottari’s recent commentary, “Rethinking Caution: A critical appraisal of extracorporeal blood purification in sepsis” [1], particularly in relation to our own comment a few weeks earlier “A few word of caution on blood purification in sepsis” [2] in the journal. We truly appreciate the encouragement of a rigorous scientific
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Traumatic brain injury management in the intensive care unit: standard of care and knowledge gaps. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-16 Chiara Robba,Victoria McCredie,Randall M Chesnut,Giuseppe Citerio,Tobias Gauss,Gregory W J Hawryluk,Raimund Helbok,Geert Meyfroidt,Virginia Newcombe,Aarti Sarwal,Fabio S Taccone,Mathieu van der Jagt,Sarah Wahlster,Elisa R Zanier,Pierre Bouzat
Despite advances in the management of traumatic brain injury (TBI) in the intensive care unit (ICU), and the implementation of new diagnostic techniques and monitoring modalities, the rate of poor neurological outcomes remains high. Specialized neurocritical care units have been shown to improve outcomes. Guidelines have been developed, but most recommendations are based on low levels of evidence.
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Publisher Correction: Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-16
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Anticoagulation management and outcomes in critically ill patients with acute mesenteric ischemia: an international study. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-16 Inès Lakbar,Louis Delamarre,Kadri Tamme,Naira Hernandez De La Torre,Joris Pensier,Clément Monet,Joel Starkopf,Mathieu Capdevila,Marc Leone,Audrey De Jong,Annika Reintam Blaser,Samir Jaber,
BACKGROUND Acute mesenteric ischemia (AMI) is associated with low survival rates. It is recommended to start early a full dose of anticoagulation therapy in patients with AMI, regardless of etiology, surgical or procedural perspective, or coagulation status. However, there are no international studies addressing the impact of timing and dose of anticoagulation therapy on outcome in AMI patients hospitalized
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Central nervous system infections rarely underlie presumed delirium in ICU admissions: insights from the Swiss ICU registry Crit. Care (IF 8.8) Pub Date : 2025-06-13 Pascale Grzonka, Sebastian Berger, Simon A. Amacher, Lisa Hert, Tolga D. Dittrich, Martin Lohri, Paulina SC Kliem, Sabina Hunziker, Sarah Tschudin Sutter, Mark Kaufmann, Caroline E. Gebhard, Raoul Sutter
Delirium, a neuropsychiatric syndrome with high morbidity and mortality, affects up to 80% of mechanically ventilated intensive care unit (ICU) patients [1] with a recently decreasing 50% incidence due to improved care [2]. Given that central nervous system (CNS) infections induce cerebral dysfunction, guidelines recommend cerebral spinal fluid (CSF) analysis in cases of unexplained neurological impairment
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Real-time changes in pulse pressure during a 10-second end-expiratory occlusion test reliably detect preload responsiveness Crit. Care (IF 8.8) Pub Date : 2025-06-13 Francesco Gavelli, Nello De Vita, Christopher Lai, Danila Azzolina, Arthur Pavot, Mathieu Jozwaik, Rui Shi, Imane Adda, Alexandra Beurton, Jean-Louis Teboul, Xavier Monnet
The end-expiratory occlusion (EEO) test detects preload responsiveness through changes in cardiac index (ΔCI) during a 15-second respiratory hold at end-expiration. We investigated the diagnostic accuracy of EEO-induced changes in arterial pulse pressure (∆PP), especially when the duration of EEO is reduced to 10’’ and 5’’, and whether adding an end-inspiratory occlusion (EIO) improves this diagnostic
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Oncology as a gateway for integrating palliative care training in intensive care: toward a contextual and scalable model. Author's reply. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-14 Mohammed Aabdi,Youssef Motiaa,Choukri Bahouh,Khalil El Yachioui,Hicham Sbai
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Storage duration of packed red blood cells transfused during veno-venous extracorporeal membrane oxygenation is associated with elevated pulmonary artery pressure and lung injury in a sheep model Crit. Care (IF 8.8) Pub Date : 2025-06-13 Fergal T. Temple, Gabriela Simonova, Margaret R. Passmore, Samuel R. Foley, Sara D. Diab, Kimble R. Dunster, Charles I. McDonald, Kiran Shekar, Yoke-Lin Fung, John-Paul Tung, John F. Fraser
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is associated with a high transfusion burden. While trials have concluded that red blood cell (RBC) storage does not impact patient morbidity and mortality in the critically ill or cardiac surgical cohorts, evidence is sparse for ECMO cohorts. A sheep model was to investigate this question. On an underlying injury of smoke inhalation, we compared
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From indication to initiation of invasive intracranial pressure monitoring time differences between neurosurgeons and intensive care physicians: can intracranial hypertension dose be reduced? TIMING-ICP, a multicenter, observational, prospective study Crit. Care (IF 8.8) Pub Date : 2025-06-13 Lara Mariani, Stefano Calza, Paolo Gritti, Simone Maria Zerbi, Emanuele Russo, Cristian Deana, Dario Filippi, Chiara Robba, Anselmo Caricato, Paola Fassini, Giacomo Dell’Avanzo, Andrea Viscone, Lucio De Maria, Luca Pisapia, Luigi Vetrugno, Gianluigi Zona, Roberto Stefini, Corrado Iaccarino, Nicola Latronico, Simone Piva, Michele Bertoni, Antonio Biroli, Marco Maria Fontanella, Frank Rasulo
The duration of episodes of intracranial hypertension is related to poor outcome, hence the need for prompt diagnosis. Numerous issues can lead to delays in the implementation of invasive intracranial pressure (ICP) monitoring, thereby increasing the dose of intracranial hypertension to which the patient is exposed. The aim of this prospective, observational, multicenter study was to assess the magnitude
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Reconsidering high-MAP targets in septic shock: the need for cardiac function-oriented resuscitation. Authors' reply. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-13 Akira Endo,Kazuma Yamakawa,Takashi Tagami,Yutaka Umemura,
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Rethinking environmental sustainability in intensive care medicine: a call for global collaboration for mutual learning. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-13 Samie Asghar Dogar,Miriam Kugele,Asad Latif
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Comment on: the use of not recommended therapies in TBI patients with refractory intracranial hypertension: authors' reply. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-13 Laura Galarza,Edoardo Picetti,Chiara Robba,Fabio Silvio Taccone
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Author Correction: Hemoadsorption in septic shock-CON. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-13 Massimo Girardis,Martina Tosi,Sascha David
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Altered lower brainstem neurophysiological response is associated with mortality in deeply sedated critically ill patients. Intensive Care Med. (IF 27.1) Pub Date : 2025-06-13 Eléonore Bouchereau,Estelle Pruvost-Robieux,Shidasp Siami,Cendrine Chaffaut,Adrien Bouglé,Martine Gavaret,Nicholas Heming,Sivanthiny Sivanandamoorthy,Julie Zyss,Vincent Degos,Stanislas Kandelman,Cassia Righy Shinotsuka,Sarah Benghanem,Lionel Naccache,Benjamin Rohaut,Bertrand Hermann,Eric Azabou,Sylvie Chevret,Tarek Sharshar
BACKGROUND AND OBJECTIVES Absent cough reflex is associated with mortality in intensive care unit (ICU) patients requiring deep sedation, suggesting that lower brainstem dysfunction contributes to adverse outcomes. We conducted a multicenter observational cohort study to confirm this hypothesis by assessing the peak latency (PL) of the lower brainstem-generated P14 evoked potential (EP), which is slightly
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Invasive group A streptococcus infections in the intensive care unit: an unsupervised cluster analysis of a multicentric retrospective cohort Crit. Care (IF 8.8) Pub Date : 2025-06-12 Tomas Urbina, Lilith Faucheux, Jean-Rémi Lavillegrand, Julien Massol, Marie Lecronier, Quentin de Roux, Matthieu Turpin, William Menard, Melchior Gautier, Guilene Barnaud, Damien Roux, Charles-Edouard Luyt, Antoine Vieillard-Baron, Guillaume Voiriot, Nicolas Mongardon, Maxens Decavele, Frédéric Pène, Jérémie Joffre, Hafid Ait-Oufella, Nicolas de Prost, Eric Maury
Invasive group A streptococcus (iGAS) infection incidence is rising. These infections have been studied as a whole but can be associated with critical illness in a population with a wide array of underlying conditions, sites of infection and clinical presentations. Using an unsupervised clustering approach, we aimed to identify specific clinical phenotypes regarding presentation, management and outcome
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Primer on large language models: an educational overview for intensivists Crit. Care (IF 8.8) Pub Date : 2025-06-12 Daphna Idan, Sharon Einav
The integration of artificial intelligence (AI) and machine learning-enabled medical technologies into clinical practice is expanding at an unprecedented pace. Among these, large language models (LLMs) represent a subset of machine learning designed to comprehend linguistic patterns, semantics, and contextual meaning by processing vast amounts of textual data. This educational primer aims to inform
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Ciprofol versus propofol sedation in ICU patients and norepinephrine requirements: a single-center prospective cohort study Crit. Care (IF 8.8) Pub Date : 2025-06-12 Zengzhu He, Jingyi Liang, Jiaxin Duan, Li Liu, Yuhang Yan, Zisheng Ma, Yue Ouyang, Houcheng Li, Hongbin Hu, Zhenhua Zeng
Ciprofol is a novel intravenous anesthetic structurally analogous to propofol and associated with a lower incidence of hypotension, widely used for procedural sedation and general anesthesia [1] but less studied for the sedation of intensive care unit (ICU) patient. The use of vasopressors is often necessary to counteract drug-induced hypotension. However, the administration of norepinephrine, particularly
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Issue Information J. Adv. Nurs. (IF 3.8) Pub Date : 2025-06-12
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Effects of Psychosocial Interventions on Loneliness Amongst Long‐Term Care Residents: A Systematic Review and Meta‐Analysis J. Adv. Nurs. (IF 3.8) Pub Date : 2025-06-12 Jodie Cheuk‐Yan Szeto, Lily Man‐Lee Chan, Wilfred Wing‐Fung Sin, Daniel Yee‐Tak Fong, Jojo Yan‐Yan Kwok
BackgroundLoneliness significantly affects the physical and mental health of older adults, particularly those in long‐term care settings. Despite the high prevalence of loneliness, comprehensive reviews on psychosocial interventions targeting loneliness in these populations are scarce.AimsTo evaluate the effects of psychosocial interventions in reducing loneliness among long‐term care residents.Study
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Exploring Nurses' Decision‐Making Through the Lens of Capability: A Framework for Understanding Autonomy in Complex Care Environments J. Adv. Nurs. (IF 3.8) Pub Date : 2025-06-12 Patrick Lavoie
AimTo apply the capability approach to understand ICU nurses’ decision‐making autonomy.DesignA qualitative study using Amartya Sen’s capability approach as a conceptual framework.MethodsThis study reanalyzed qualitative data from a previous investigation involving semi‐structured interviews with 39 experienced Canadian ICU nurses who described their decision‐making processes in managing post‐cardiac
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Experiences of Nurses With Power‐Structures in Hospital Care: A Qualitative Study J. Adv. Nurs. (IF 3.8) Pub Date : 2025-06-12 Martijn Vos, Mireille Stelwagen, Margot Brinkhof, Anne Eskes, Fedde Scheele, Cees Hamelink, Carina Pittens, Dirk Essink
AimTo explore nurses' experiences with power structures in hospital care and to develop policy recommendations for transforming disempowering structures.DesignA three‐phased critical ethnographic design.MethodData were collected in a general teaching hospital in the Netherlands between December 2022 and June 2024 through (1) ethnographic diaries kept by nurses, (2) semi‐structured interviews, (3) partial
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Beyond Everyday Small Talk: A Qualitative Study on Registered Nurses' Confidential Conversations in Palliative Care J. Adv. Nurs. (IF 3.8) Pub Date : 2025-06-12 Tove Stenman, Ylva Rönngren, Ulla Näppä, Christina Melin Johansson
AimTo explore and gain a deeper understanding of how registered nurses in palliative care develop personal and professional approaches in confidential conversations with patients.DesignA qualitative study using focus groups.MethodBetween March and May 2024, 22 registered nurses working in specialised palliative care in the northern region of Sweden participated in five focus groups. The discussions
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Exploring the Impact of the Motherhood Penalty on Critical Care Nurses: A Hermeneutic Phenomenological Study J. Adv. Nurs. (IF 3.8) Pub Date : 2025-06-12 Adrianna Lorraine Watson, Carly Peterson, Tali Gardner, Chelsey Young, Grace Houston, Brooklynn Nelson, Sienna Blank
AimThis study explores the lived experiences of critical care nurses who are also mothers, focusing on their challenges with breastfeeding and pumping at work.MethodsUsing interpretive phenomenology, grounded in Martin Heidegger's work, semi‐structured interviews were conducted with critical care nurses (N = 54) who were also breastfeeding mothers in the United States in 2024. Data were transcribed
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Health‐Promoting Lifestyle and Associated Factors Among Head and Neck Cancer Patients in Northeast China: A Cross‐Sectional Study J. Adv. Nurs. (IF 3.8) Pub Date : 2025-06-12 Zhuoran Gao, Siyu Li, Yanzhongcheng Xu, Min Zhang, Jingjing Wang, Xinghua Bai
ObjectivesHealth‐promoting lifestyle (HPL) is strongly associated with health outcomes. In clinical practice, health‐promotion behaviours in patients with head and neck cancer (HNC) are not good, which seriously affects patients' prognosis. This study aims to investigate the current status and influencing factors of HPL in HNC patients.DesignA cross‐sectional study.MethodsThis study used a convenience
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