Endotracheal Intubation (ETI) is a common procedure in the emergency department and intensive care units (ICUs). In contrast to elective surgical patients, critically ill patients often face acute hypoxemic events related to underlying pulmonary pathology, elevated metabolic demands, impaired respiratory drive, obesity, or an inability to protect the airway from aspiration. Nearly half of emergency

Ventilatory support levels in ICU patients should be tailored to both optimal gas exchange and respiratory muscle loading, as over- and underassistance may cause diaphragm dysfunction. The diaphragm’s capacity to overcome mechanical load and deliver ventilatory output is reflected by the patient’s neural respiratory drive (NRD), tidal volume (TV) and respiratory rate (RR). Surface electromyography

Tobacco use remains one of the world's greatest public health challenges, contributing substantially to morbidity and mortality. Effective and accessible smoking cessation interventions are essential to reducing tobacco-related health risks. Acceptance and Commitment Therapy (ACT) has demonstrated efficacy in enhancing quit rates. However, the effectiveness of technology-based ACT, a more accessible

Chronic graft-versus-host disease (cGVHD) is a leading long-term complication following allogeneic hematopoietic stem-cell transplantation (Allo-HSCT). However, its impact on outcomes in critically ill Allo-HSCT recipients has little been evaluated. We conducted a post hoc analysis of a multicenter cohort study involving Allo-HSCT recipients admitted to 14 French intensive care units (ICUs) between

Sepsis remains a leading cause of pediatric morbidity and mortality worldwide. Septic shock, a progression of sepsis characterized by profound cardiovascular dysfunction, carries mortality rates as high as 40–80% and often results in long-term neurocognitive deficits. In patients with septic shock, vasoplegia is the worse presentation of hemodynamics which related higher mortality. Vasoplegia is an

A systemic inflammatory response can contribute to poor outcomes in an advanced stage of cardiogenic shock (CS). We investigated the efficacy of extracorporeal endotoxin and cytokine adsorption using oXiris in patients with CS undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO). In this prospective, single-center, randomized, open-label pilot trial, 40 patients with CS who were undergoing

Herpesviruses are widely distributed in the lower respiratory tract, yet no study has comprehensively characterized their clinical features and prognostic impact in severe pneumonia. In this multicenter, retrospective study, we included severe pneumonia patients who underwent bronchoalveolar lavage fluid (BALF) metagenomic testing in intensive care units across 17 medical centers from January 2019

High-quality nursing care is crucial for healthcare quality and safety, yet there's limited understanding of the business case for investing in nursing from an organizational perspective. This study seeks to address this evidence gap by identifying and synthesizing data on the organizational return on investment from nursing human capital, considering initial investment costs and the resulting impact

AimTo gain an understanding of the experiences of mentors and mentees engaging in a national mentoring programme within nursing and midwifery in Ireland.DesignA two‐phased convergent parallel mixed methods study was undertaken.MethodsThe first phase was a quantitative non‐experimental descriptive study using an online survey with mentors (n = 12) and mentees (n = 6). The second phase was a qualitative

AimThis study investigates work‐related stress, moral reward and job satisfaction among healthcare professionals in the postpandemic era, focusing on the psychological and professional challenges they face. The study examines the role of excessive demands, inadequate support and reward imbalances, and explores the impact on healthcare workers' well‐being and patient care quality.DesignUtilising a quantitative

AimsWe aimed to identify the barriers and facilitators to participation in interventions aimed at improving cognitive function among older adults with type 2 diabetes mellitus (T2DM) and mild cognitive impairment (MCI) in rural areas.DesignThis study is the qualitative phase of a larger randomised controlled trial and employs a descriptive approach.MethodsWe conducted in‐depth, semi‐structured face‐to‐face

AimTo examine nurses' perceptions of decent work (defined by the ILO as safe, fair and socially recognised employment) and its relationship with work‐related flow and psychological capital.DesignA cross‐sectional survey design.MethodsIn 2023, we used convenient sampling to select 1930 nurses from 20 high‐grade A hospitals. A general data questionnaire, decent work perception scale (DWPS), work‐related

AimsInvestigate if UK healthcare professionals have the resources and knowledge to provide cardiovascular prevention and rehabilitation to people with ischaemic non‐obstructive coronary artery disease (INOCA), and explore what type of care healthcare professionals believe patients should receive.DesignElectronic cross‐sectional survey of UK healthcare professionals, circulated between 7 January and

Mortality in patients with acute respiratory failure remains high. Predicting progression of acute respiratory failure may be critical to improving patient outcomes. Machine learning, a subset of artificial intelligence is a rapidly expanding area, which is being integrated into several areas of clinical medicine. This manuscript will address the knowledge gap in predicting the onset and progression

Epinephrine use in cardiac arrest is increasingly controversial, with contrasting results according to initial rhythm. We assessed the association between epinephrine use and favorable neurological outcome among patients with out of hospital cardiac arrest with refractory shockable arrest. In this multicentric population-based prospective registry, we included all patients with out-of-hospital cardiac

Ventilator-free days (VFDs) are a composite outcome in critical care research, reflecting both survival and mechanical ventilation duration. However, analysis methods for VFDs are inconsistent, with some focusing on counts and others on time-to-event outcomes, while other approaches such as the multistate model and the win ratio have emerged. We aimed to evaluate various statistical models through

Dear Editor, Five and a half years since its emergence, despite widespread vaccination efforts, COVID-19 has not disappeared due to viral evolution similar to influenza virus variants, with recurrent sporadic outbreaks occurring in many regions, cities, and countries. Consequently, intensivists worldwide continue to face severe cases, making it crucial to synthesize evidence for managing critically

In critically ill patients, early hemodynamic assessment is essential for guiding shock resuscitation. While cardiac output (CO) is a key indicator of circulatory status, its measurement is often limited by technical and practical constraints. This perspective explores the physiological and clinical relevance of pulse pressure (PP) as a potential surrogate for stroke volume (SV), emphasizing its accessibility

Survivors of intensive care unit (ICU) are increasingly numerous because of better hospital care. However, several consequences of an ICU stay, known as post-intensive care syndrome, worsen long-term prognoses. A predominant feature in survivors is reduced muscle strength, mass, and physical function. This leads to lower exercise capacity, long-lasting physical disability, higher mortality risk, and

Retention of newly qualified nurses is a challenge for health services worldwide. Graduate transition programs tend to provide top-down approaches that enlist senior nurses to mentor and train newly qualified nurses. Although peer support between newly qualified nurses has been shown to improve their experiences, existing studies mainly focus on support provided by senior nurses. Strategies focused

It is now widely recognised that in addition to providing robust evidence about intervention effectiveness, systematic reviews need to provide decision-makers with information about critical intervention, contextual and implementation features that support successful outcomes. Our 2015 paper introduced Intervention Component Analysis (ICA), a method comprised of three key approaches for examining trials

We live in a post-humanist world, where the lines are blurred between human and non-human persons. We are in this space where the human and non-human, are all intersecting and creating overlaps that are no longer clearly defined. Posthumanism has existed for a very long time, through indigenous cultures where the earth, the land, trees and waters are treated with the same respect and criteria as those

AimTo explore community nurses' experiences of changes to their roles in palliative and end‐of‐life care.DesignAn e‐survey was followed by focus groups.MethodsFifty‐one community nurses with recent experience of delivering end‐of‐life care in the United Kingdom completed a survey about changes to their roles. A purposive sample of 35 respondents participated in focus groups exploring these changes

The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening. This was a post hoc analysis of the TTM2-trial, which randomized 1900

Selective Digestive Decontamination (SDD) prevents infections and reduces mortality in the intensive care unit (ICU). Microbiological surveillance is considered essential for effective decontamination and detecting antibiotic resistance. However, its optimal frequency is unclear. We compared microbiological yield and costs of different surveillance intervals during SDD. In a computational simulation

Dear Editor, We read with great interest the study by Romero-Garcia et al. titled “Neurological outcomes and mortality following hyperoxemia in adult patients with acute brain injury: an updated meta-analysis and meta-regression” [1]. The analysis regarding oxygen concentration and neurological outcomes was particularly compelling. However, we would like to highlight a point regarding the cardiac arrest

Dysphagia (i.e. an impairment in swallowing function that impacts on safety or efficiency) is present in many intensive care unit (ICU) survivors, in particular following extubation (“post-extubation dysphagia”, PED). Despite the fact that pathomechanisms leading to PED are currently incompletely understood, local as well as central neurological and neuromuscular dysfunctions may be key to development

Despite longstanding rhetorical commitments to diversity, equity and inclusion, racism remains a pervasive and a systemic force within the nursing profession, shaping experiences of both the workforce and the populations they serve. A recent UK survey found that 75% of nurses from ethnic minority backgrounds reported experiencing racial discrimination from colleagues or patients, resulting in stress

BackgroundDysphagia not only affects the nutritional intake of head and neck cancer (HNC) patients but may also lead to social avoidance, emotional fluctuations, and a decline in life confidence. Furthermore, dysphagia places an additional psychological and physical burden on caregivers, significantly altering their lifestyles.MethodThis study employed a qualitative systematic review approach to comprehensively

AimTo identify successful strategies and underpinning mechanisms for retaining nurses in home visiting nursing services.DesignScoping review.Data SourcesMEDLINE, CINAHL, Google Scholar, Theses Global Databases (1 January 2000 to 23 November 2023); international nursing organisations websites (January–April 2024).Review MethodsThe methods followed the Joanna Briggs Institute guidance. Two researchers

AimTo explore how classmate ‘ambassadors’ experienced and engaged in social interaction while visiting a hospitalised peer undergoing cancer treatment.DesignA phenomenological‐hermeneutic inspired exploratory study.MethodsUsing on‐the‐go semi‐structured interviews and participant observations from January to December 2023 in Denmark, we included 27 school‐aged ambassadors aged 6–18 years old; 18 participated

AimThis study aims to examine the experiences and support needs of internationally educated nurses (IENs) who migrated from Türkiye to different countries.BackgroundWith the impact of globalisation and changes in the healthcare sector, the migration of IENs is on the rise. The global shortage of nurses has prompted high‐income countries to increase their recruitment of nurses from low‐ and middle‐income

AimThis study examines the effect of nurses' holistic nursing competency levels and humanistic behaviour skills on their professional pride levels.DesignThe study was designed as a cross‐sectional study.MethodsThe sample consisted of 224 nurses working in a city hospital. The data were collected using the Personal Information Form, the Holistic Nursing Competence Scale, the Humanistic Behaviour Skill

AimTo report how mentorship influences the educational experiences and training of doctoral nursing students.DesignIntegrative literature review.MethodsPeer‐reviewed journal articles, theoretical works and editorials published in English that focused on doctoral nursing education were included. Papers reporting on mentorship for undergraduate nursing students, nursing faculty, educators, academics

Dear editor, We find ourselves grappling with certain aspects of Gabriella Bottari’s recent commentary, “Rethinking Caution: A critical appraisal of extracorporeal blood purification in sepsis” [1], particularly in relation to our own comment a few weeks earlier “A few word of caution on blood purification in sepsis” [2] in the journal. We truly appreciate the encouragement of a rigorous scientific

Despite advances in the management of traumatic brain injury (TBI) in the intensive care unit (ICU), and the implementation of new diagnostic techniques and monitoring modalities, the rate of poor neurological outcomes remains high. Specialized neurocritical care units have been shown to improve outcomes. Guidelines have been developed, but most recommendations are based on low levels of evidence.

BACKGROUND Acute mesenteric ischemia (AMI) is associated with low survival rates. It is recommended to start early a full dose of anticoagulation therapy in patients with AMI, regardless of etiology, surgical or procedural perspective, or coagulation status. However, there are no international studies addressing the impact of timing and dose of anticoagulation therapy on outcome in AMI patients hospitalized

Delirium, a neuropsychiatric syndrome with high morbidity and mortality, affects up to 80% of mechanically ventilated intensive care unit (ICU) patients [1] with a recently decreasing 50% incidence due to improved care [2]. Given that central nervous system (CNS) infections induce cerebral dysfunction, guidelines recommend cerebral spinal fluid (CSF) analysis in cases of unexplained neurological impairment

The end-expiratory occlusion (EEO) test detects preload responsiveness through changes in cardiac index (ΔCI) during a 15-second respiratory hold at end-expiration. We investigated the diagnostic accuracy of EEO-induced changes in arterial pulse pressure (∆PP), especially when the duration of EEO is reduced to 10’’ and 5’’, and whether adding an end-inspiratory occlusion (EIO) improves this diagnostic

Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is associated with a high transfusion burden. While trials have concluded that red blood cell (RBC) storage does not impact patient morbidity and mortality in the critically ill or cardiac surgical cohorts, evidence is sparse for ECMO cohorts. A sheep model was to investigate this question. On an underlying injury of smoke inhalation, we compared

The duration of episodes of intracranial hypertension is related to poor outcome, hence the need for prompt diagnosis. Numerous issues can lead to delays in the implementation of invasive intracranial pressure (ICP) monitoring, thereby increasing the dose of intracranial hypertension to which the patient is exposed. The aim of this prospective, observational, multicenter study was to assess the magnitude

BACKGROUND AND OBJECTIVES Absent cough reflex is associated with mortality in intensive care unit (ICU) patients requiring deep sedation, suggesting that lower brainstem dysfunction contributes to adverse outcomes. We conducted a multicenter observational cohort study to confirm this hypothesis by assessing the peak latency (PL) of the lower brainstem-generated P14 evoked potential (EP), which is slightly

Invasive group A streptococcus (iGAS) infection incidence is rising. These infections have been studied as a whole but can be associated with critical illness in a population with a wide array of underlying conditions, sites of infection and clinical presentations. Using an unsupervised clustering approach, we aimed to identify specific clinical phenotypes regarding presentation, management and outcome

The integration of artificial intelligence (AI) and machine learning-enabled medical technologies into clinical practice is expanding at an unprecedented pace. Among these, large language models (LLMs) represent a subset of machine learning designed to comprehend linguistic patterns, semantics, and contextual meaning by processing vast amounts of textual data. This educational primer aims to inform

Ciprofol is a novel intravenous anesthetic structurally analogous to propofol and associated with a lower incidence of hypotension, widely used for procedural sedation and general anesthesia [1] but less studied for the sedation of intensive care unit (ICU) patient. The use of vasopressors is often necessary to counteract drug-induced hypotension. However, the administration of norepinephrine, particularly

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BackgroundLoneliness significantly affects the physical and mental health of older adults, particularly those in long‐term care settings. Despite the high prevalence of loneliness, comprehensive reviews on psychosocial interventions targeting loneliness in these populations are scarce.AimsTo evaluate the effects of psychosocial interventions in reducing loneliness among long‐term care residents.Study

AimTo apply the capability approach to understand ICU nurses’ decision‐making autonomy.DesignA qualitative study using Amartya Sen’s capability approach as a conceptual framework.MethodsThis study reanalyzed qualitative data from a previous investigation involving semi‐structured interviews with 39 experienced Canadian ICU nurses who described their decision‐making processes in managing post‐cardiac

AimTo explore nurses' experiences with power structures in hospital care and to develop policy recommendations for transforming disempowering structures.DesignA three‐phased critical ethnographic design.MethodData were collected in a general teaching hospital in the Netherlands between December 2022 and June 2024 through (1) ethnographic diaries kept by nurses, (2) semi‐structured interviews, (3) partial

AimTo explore and gain a deeper understanding of how registered nurses in palliative care develop personal and professional approaches in confidential conversations with patients.DesignA qualitative study using focus groups.MethodBetween March and May 2024, 22 registered nurses working in specialised palliative care in the northern region of Sweden participated in five focus groups. The discussions

AimThis study explores the lived experiences of critical care nurses who are also mothers, focusing on their challenges with breastfeeding and pumping at work.MethodsUsing interpretive phenomenology, grounded in Martin Heidegger's work, semi‐structured interviews were conducted with critical care nurses (N = 54) who were also breastfeeding mothers in the United States in 2024. Data were transcribed

ObjectivesHealth‐promoting lifestyle (HPL) is strongly associated with health outcomes. In clinical practice, health‐promotion behaviours in patients with head and neck cancer (HNC) are not good, which seriously affects patients' prognosis. This study aims to investigate the current status and influencing factors of HPL in HNC patients.DesignA cross‐sectional study.MethodsThis study used a convenience