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Macrophages overexpressing interleukin‐10 target and prevent atherosclerosis: Regression of plaque formation and reduction in necrotic core Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-09-17 Mingyi Wang, Shanshan Zhou, Yingyun Hu, Wei Tong, Hao Zhou, Mingrui Ma, Xingxuan Cai, Zhengbin Zhang, Luo Zhang, Yundai Chen
Atherosclerosis, a slowly progressing inflammatory disease, is characterized by the presence of monocyte‐derived macrophages. Interventions targeting the inflammatory characteristics of atherosclerosis hold promising potential. Although interleukin (IL)‐10 is widely acknowledged for its anti‐inflammatory effects, systemic administration of IL‐10 has limitations due to its short half‐life and significant
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Elucidating the role of carrier proteins in cytokine stabilization within double emulsion‐based polymeric nanoparticles Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-09-06 Emily R. Rhodes, Nicole B. Day, Emma C. Aldrich, C. Wyatt Shields, Kayla G. Sprenger
Polymeric micro‐ and nanoparticles are useful vehicles for delivering cytokines to diseased tissues such as solid tumors. Double emulsion solvent evaporation is one of the most common techniques to formulate cytokines into vehicles made from hydrophobic polymers; however, the liquid–liquid interfaces formed during emulsification can greatly affect the stability and therapeutic performance of encapsulated
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A stretchable human lung‐on‐chip model of alveolar inflammation for evaluating anti‐inflammatory drug response Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-09-05 Clémentine Richter, Lorenz Latta, Daria Harig, Patrick Carius, Janick D. Stucki, Nina Hobi, Andreas Hugi, Paul Schumacher, Tobias Krebs, Alexander Gamrekeli, Felix Stöckle, Klaus Urbschat, Galia Montalvo, Franziska Lautenschläger, Brigitta Loretz, Alberto Hidalgo, Nicole Schneider‐Daum, Claus‐Michael Lehr
This study describes a complex human in vitro model for evaluating anti‐inflammatory drug response in the alveoli that may contribute to the reduction of animal testing in the pre‐clinical stage of drug development. The model is based on the human alveolar epithelial cell line Arlo co‐cultured with macrophages differentiated from the THP‐1 cell line, creating a physiological biological microenvironment
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Advances in bioengineered CAR T/NK cell therapy for glioblastoma: Overcoming immunosuppression and nanotechnology‐based strategies for enhanced CAR T/NK cell therapy Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-31 Nasim Dana, Arezou Dabiri, Majed Bahri Najafi, Azadeh Rahimi, Sayed Mohammad Matin Ishaghi, Laleh Shariati, Minmin Shao, Assunta Borzacchiello, Ilnaz Rahimmanesh, Pooyan Makvandi
Glioblastoma is a strong challenge in the worldwide field of central nervous system malignancies. GBM's inherent heterogeneity, along with the formation of an immunosuppressive tumor microenvironment, supports its resistance to current therapy methods. Immunotherapeutic methods have emerged as potential options in recent years. However, because of the inherent limits of traditional immunotherapeutic
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Targeting the epigenome with advanced delivery strategies for epigenetic modulators Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-17 Sonia Guha, Yogeswaran Jagadeesan, Murali Monohar Pandey, Anupama Mittal, Deepak Chitkara
Epigenetics mechanisms play a significant role in human diseases by altering DNA methylation status, chromatin structure, and/or modifying histone proteins. By modulating the epigenetic status, the expression of genes can be regulated without any change in the DNA sequence itself. Epigenetic drugs exhibit promising therapeutic efficacy against several epigenetically originated diseases including several
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A temperature responsive hydrogel encapsulated with adipose‐derived stem cells and melanin promotes repair and regeneration of endometrial injury Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-16 Ruigao Song, Chicheng Ma, Hongxia Li, Yu Cheng, Xianmei Cui, Zanhong Wang, Lijuan Huang, Chunying Song, Yukai Jing, Bing Cao, Lili Wang, Qing Tian, Xi Wang, Ruiping Zhang, Hanwang Zhang
The endometrium, the inner lining of the uterus, assumes a crucial role in the female reproductive system. Disorders and injuries impacting the endometrium can lead to profound consequences, including infertility and compromised women's overall health. Recent advancements in stem cell research have opened new possibilities for the treatment and repair of endometrial issues. In the present study, we
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Unleashing the potential of mRNA: Overcoming delivery challenges with nanoparticles Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-15 Qiang Chen, Ku‐Geng Huo, Sheng‐Min Ji, Shu‐De Pang, Tian‐Ying Sun, Yi Niu, Zi‐Hao Jiang, Peng Zhang, Shu‐Xin Han, Jin‐Yao Li
Messenger RNA (mRNA) has emerged as a promising therapeutic strategy for various diseases, including cancer, infectious diseases, and genetic disorders. The mRNA‐based therapeutics have gained significant attention due to their ability to regulate targeted cells, activate immune cells, and avoid potential risks associated with DNA‐based technology. However, the clinical application of mRNA in cancer
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MHCI trafficking signal‐based mRNA vaccines strengthening immune protection against RNA viruses Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-15 Yupei Zhang, Songhui Zhai, Shugang Qin, Yuting Chen, Kepan Chen, Zhiying Huang, Xing Lan, Yaoyao Luo, Guohong Li, Hao Li, Xi He, Meiwan Chen, Zhongwei Zhang, Xingchen Peng, Xin Jiang, Hai Huang, Xiangrong Song
The major histocompatibility complex class I (MHCI) trafficking signal (MITD) plays a pivotal role in enhancing the efficacy of mRNA vaccines. However, there was a lack of research investigating its efficacy in enhancing immune responses to RNA virus infections. Here, we have developed an innovative strategy for the formulation of mRNA vaccines. This approach involved the integration of MITD into the
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Activated neutrophils: A next generation cellular immunotherapy Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-13 Ninad Kumbhojkar, Samir Mitragotri
Cell therapies are at the forefront of novel therapeutics. Neutrophils, despite being the most populous immune cells in human blood circulation, are not considered a viable option for cellular therapies because of their short lifespan and poor understanding of their role in the pathophysiology of various diseases. In inflammatory conditions, neutrophils exhibit an activated phenotype. Activation brings
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Immunotherapy against glioblastoma using backpack‐activated neutrophils Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-13 Tatsuya Fukuta, Ninad Kumbhojkar, Supriya Prakash, Suyog Shaha, A. Da Silva‐Candal, Kyung Soo Park, Samir Mitragotri
Immune checkpoint inhibitors (ICIs) represent new therapeutic candidates against glioblastoma multiforme (GBM); however, their efficacy is clinically limited due to both local and systemic immunosuppressive environments. Hence, therapeutic approaches that stimulate local and systemic immune environments can improve the efficacy of ICIs. Here, we report an adoptive cell therapy employing neutrophils
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Human adipose‐derived multipotent stromal cells enriched with IL‐10 modRNA improve diabetic wound healing: Trigger the macrophage phenotype shift Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-07 Yuxin Zhang, Wei Wang, Liang Chen, Heng Wang, Dong Dong, Jingjing Zhu, Yu Guo, Yiqun Zhou, Tianyi Liu, Wei Fu
Diabetic wounds present a significant challenge in regenerative medicine due to impaired healing, characterized by prolonged inflammation and deficient tissue repair, primarily caused by a skewed pro‐inflammatory macrophage phenotype. This study investigates the therapeutic potential of interleukin‐10 (IL‐10) chemically modified mRNA (modRNA)‐enriched human adipose‐derived multipotent stromal cells
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Mesenchymal stem cells for osteoarthritis: Recent advances in related cell therapy Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-05 Jianjing Lin, Jingtao Huang, Zilu Jiao, Mengyuan Nian, Canfeng Li, Yali Dai, Shicheng Jia, Xintao Zhang
Osteoarthritis (OA) is a degenerative joint disease that affects the entire joint and has been a huge burden on the health care system worldwide. Although traditional therapy and targeted cartilage cell therapy have made significant progress in the treatment of OA and cartilage regeneration, there are still many problems. Mesenchymal stem cells from various tissues are the most studied cell type and
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Bilayer 3D co‐culture platform inducing the differentiation of normal fibroblasts into cancer‐associated fibroblast like cells: New in vitro source to obtain cancer‐associated fibroblasts Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-05 Yeon Ju Kim, Hyeon Song Lee, Dohyun Kim, Hwa Kyung Byun, Woong Sub Koom, Won‐Gun Koh
This study presents a novel in vitro bilayer 3D co‐culture platform designed to obtain cancer‐associated fibroblasts (CAFs)‐like cells. The platform consists of a bilayer hydrogel structure with a collagen/polyethylene glycol (PEG) hydrogel for fibroblasts as the upper layer and an alginate hydrogel for tumor cells as the lower layer. The platform enabled paracrine interactions between fibroblasts
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Sperm quality analyzer: A portable LED array microscope with dark‐field imaging Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-02 Meng Shao, Changxu Li, Xiaohao Ma, Haoyu Pan, Zeyu Ke, Rui Liu, Zhiguo Zhang, Min‐Cheng Zhong, Yi Wang, Zhensheng Zhong, Fengya Lu, Xunbin Wei, Jinhua Zhou
Sperm quality analysis plays an important role in diagnosing infertility, which is widely implemented by computer‐assisted sperm analysis (CASA) of sperm‐swimming imaging from commercial phase‐contrast microscopy. A well‐equipped microscope comes with a high cost, increasing the burden of assessment, and it also occupies a large volume. For point‐of‐care testing (POCT) of sperm quality, these factors
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Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-08-01 Ximo Zhang, Abdullah Al‐Danakh, Xinqing Zhu, Dan Feng, Linlin Yang, Haotian Wu, Yingying Li, Shujing Wang, Qiwei Chen, Deyong Yang
The tumor microenvironment (TME) is critical for cancer initiation, growth, metastasis, and therapeutic resistance. The extracellular matrix (ECM) is a significant tumor component that serves various functions, including mechanical support, TME regulation, and signal molecule generation. The quantity and cross‐linking status of ECM components are crucial factors in tumor development, as they determine
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Development of a biocompatible 3D hydrogel scaffold using continuous liquid interface production for the delivery of cell therapies to treat recurrent glioblastoma Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-31 Lauren Kass, Morrent Thang, Yu Zhang, Cathleen DeVane, Julia Logan, Addis Tessema, Jillian Perry, Shawn Hingtgen
Glioblastoma (GBM) is the most common primary malignant brain tumor diagnosed in adults, carrying with it an extremely poor prognosis and limited options for effective treatment. Various cell therapies have emerged as promising candidates for GBM treatment but fail in the clinic due to poor tumor trafficking, poor transplantation efficiency, and high systemic toxicity. In this study, we design, characterize
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The search for an optimal tissue‐engineered urethra model for clinical application based on preclinical trials in male animals: A systematic review and meta‐analysis Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-23 Natalia Chepelova, Guzel Sagitova, Daniel Munblit, Aleksandr Suvorov, Andrey Morozov, Anastasia Shpichka, Peter Glybochko, Peter Timashev, Denis Butnaru
Tissue engineering has emerged as a promising avenue for reconstructive urology, though only a limited number of tissue‐engineered urethral constructs have advanced to clinical testing. Presently, there exists a dearth of agreement regarding the most promising constructs deserving of implementation in clinical practice. The objective of this review was to provide a comprehensive analysis of preclinical
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Intra‐lymph node crosslinking of antigen‐bearing polymers enhances humoral immunity and dendritic cell activation Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-17 Erin M. Euliano, Anushka Agrawal, Marina H. Yu, Tyler P. Graf, Emily M. Henrich, Alyssa A. Kunkel, Chia‐Chien Hsu, Tsvetelina Baryakova, Kevin J. McHugh
Lymph node (LN)‐resident dendritic cells (DCs) are a promising target for vaccination given their professional antigen‐presenting capabilities and proximity to a high concentration of immune cells. Direct intra‐LN injection has been shown to greatly enhance the immune response to vaccine antigens compared to traditional intramuscular injection, but it is infeasible to implement clinically in a vaccination
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Diagnosis of pregnancy disorder in the first‐trimester patient plasma with Raman spectroscopy and protein analysis Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-17 Ansuja P. Mathew, Gabriel Cutshaw, Olivia Appel, Meghan Funk, Lilly Synan, Joshua Waite, Saman Ghazvini, Xiaona Wen, Soumik Sarkar, Mark Santillan, Donna Santillan, Rizia Bardhan
Gestational diabetes mellitus (GDM) is a pregnancy disorder associated with short‐ and long‐term adverse outcomes in both mothers and infants. The current clinical test of blood glucose levels late in the second trimester is inadequate for early detection of GDM. Here we show the utility of Raman spectroscopy (RS) for rapid and highly sensitive maternal metabolome screening for GDM in the first trimester
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Matrix metalloproteinase 2‐responsive dual‐drug‐loaded self‐assembling peptides suppress tumor growth and enhance breast cancer therapy Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-17 Jihong Ma, Haiyan Yang, Xue Tian, Fanhu Meng, Xiaoqing Zhai, Aimei Li, Chuntao Li, Min Wang, Guohui Wang, Chunbo Lu, Jingkun Bai
Conventional chemotherapeutic agents are limited by their lack of targeting and penetration and their short retention time, and chemotherapy might induce an immune suppressive environment. Peptide self‐assembly can result in a specific morphology, and the resulting morphological changes are stimuli responsive to the external environment, which is important for drug permeation and retention of encapsulated
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Effect of artificial lung fiber bundle geometric design on micro‐ and macro‐scale clot formation Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-17 Angela Lai, Natsuha Omori, Julia E. Napolitano, James F. Antaki, Keith E. Cook
The hollow fiber membrane bundle is the functional component of artificial lungs, transferring oxygen to and carbon dioxide from the blood. It is also the primary location of blood clot formation and propagation in these devices. The geometric design of fiber bundles is defined by a narrow set of parameters that determine gas exchange efficiency and blood flow resistance, principally: fiber packing
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Light‐activatable minimally invasive ethyl cellulose ethanol ablation: Biodistribution and potential applications Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-13 Jeffrey Yang, Chen‐Hua Ma, John A. Quinlan, Kathryn McNaughton, Taya Lee, Peter Shin, Tessa Hauser, Michele L. Kaluzienski, Shruti Vig, Tri T. Quang, Matthew F. Starost, Huang‐Chiao Huang, Jenna L. Mueller
While surgical resection is a mainstay of cancer treatment, many tumors are unresectable due to stage, location, or comorbidities. Ablative therapies, which cause local destruction of tumors, are effective alternatives to surgical excision in several settings. Ethanol ablation is one such ablative treatment modality in which ethanol is directly injected into tumor nodules. Ethanol, however, tends to
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Cowpea mosaic virus intratumoral immunotherapy maintains stability and efficacy after long‐term storage Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-07 Andrea Simms, Zhongchao Zhao, Edward Cedrone, Marina A. Dobrovolskaia, Nicole F. Steinmetz
Cowpea mosaic virus (CPMV) has demonstrated superior immune stimulation and efficacy as an intratumoral immunotherapy, providing a strong argument for its clinical translation. One important consideration for any new drug candidate is the long‐term stability of the drug and its formulation. Therefore, our lab has evaluated the physical stability and biological activity, that is, anti‐tumor potency
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Advances in xenogeneic donor decellularized organs: A review on studies with sheep and porcine‐derived heart valves Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-07-04 Muslum Suleyman Inal, Huseyin Avci, Shabir Hassan, Cihan Darcan, Su Ryon Shin, Ali Akpek
Heart valve replacement surgeries are performed on patients suffering from abnormal heart valve function. In these operations, the problematic tissue is replaced with mechanical valves or with bioprosthetics that are being developed. The thrombotic effect of mechanical valves, reflecting the need for lifelong use of anticoagulation drugs, and the short‐lived nature of biological valves make these two
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Integrating routine blood biomarkers and artificial intelligence for supporting diagnosis of silicosis in engineered stone workers Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-06-29 Daniel Sanchez‐Morillo, Antonio León‐Jiménez, María Guerrero‐Chanivet, Gema Jiménez‐Gómez, Antonio Hidalgo‐Molina, Antonio Campos‐Caro
Engineered stone silicosis (ESS), primarily caused by inhaling respirable crystalline silica, poses a significant occupational health risk globally. ESS has no effective treatment and presents a rapid progression from simple silicosis (SS) to progressive massive fibrosis (PMF), with respiratory failure and death. Despite the use of diagnostic methods like chest x‐rays and high‐resolution computed tomography
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Assessing the impact of long‐term storage on the quality and integrity of biological specimens in a reproductive biobank Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-06-26 Zhao Wang, Changming Zhang, Xin Zhang, Yuehong Bian, Yongzhi Cao
Biobanks hold a pivotal role in facilitating translational and clinical research endeavors. However, the effects of prolonged storage on frozen blood samples analytes are not well defined yet. The aim of this study was to investigate the long‐term stability of the quality of DNA, RNA, and endocrine markers within blood samples amassed from the biobank over the past 11 years. The results show that the
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Propionate‐producing engineered probiotics ameliorated murine ulcerative colitis by restoring anti‐inflammatory macrophage via the GPR43/HDAC1/IL‐10 axis Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-27 Guangbo Kang, Xiaoli Wang, Mengxue Gao, Lina Wang, Zelin Feng, Shuxian Meng, Jiahao Wu, Zhixin Zhu, Xinran Gao, Xiaocang Cao, He Huang
Inflammatory bowel disease (IBD) is a chronic and unspecific inflammatory disorder of the gastrointestinal tract, and current treatment options often fail to maintain long‐term remission. Studies have shown that propionate level is reduced in fecal samples from patients with IBD. Propionate can ameliorate IBD through intestinal epithelial cells and immune regulation, but its effects on the inflammatory
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Enabling next‐generation therapies: A foreword to a special issue on nanotechnology in medicine Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-24 Josué Sznitman
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Statistical process monitoring creates a hemodynamic trajectory map after pediatric cardiac surgery: A case study of the arterial switch operation Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-16 Daniel P. Howsmon, Matthew F. Mikulski, Nikhil Kabra, Joyce Northrup, Daniel Stromberg, Charles D. Fraser, Carlos M. Mery, Richard P. Lion
Postoperative critical care management of congenital heart disease patients requires prompt intervention when the patient deviates significantly from clinician‐determined vital sign and hemodynamic goals. Current monitoring systems only allow for static thresholds to be set on individual variables, despite the expectations that these signals change as the patient recovers and that variables interact
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Hydrogels in the clinic: An update Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-16 John R. Clegg, Kolade Adebowale, Zongmin Zhao, Samir Mitragotri
Hydrogels have been used in the clinic since the late 1980s with broad applications in drug delivery, cosmetics, tissue regeneration, among many other areas. The past three decades have witnessed rapid advances in the fields of polymer chemistry, crosslinking approaches, and hydrogel fabrication methods, which have collectively brought many new hydrogel products, either injectable or non‐injectable
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Pilot PET study of vaginally administered bioadhesive nanoparticles in cynomolgus monkeys: Kinetics and safety evaluation Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-10 Molly K. Grun, Praveen Honhar, Yazhe Wang, Samantha Rossano, Minsoo Khang, Hee Won Suh, Krista Fowles, Harvey J. Kliman, Alessandra Cavaliere, Richard E. Carson, Bernadette Marquez‐Nostra, W. Mark Saltzman
Long‐lasting vaginal dosage forms could improve the therapeutic efficacy of vaginal microbicides, but achieving long‐term delivery to the vaginal canal has been a significant challenge. To advance understanding of vaginal dosage retention and biodistribution, we describe a method of noninvasive imaging with 89Zr‐labeled bioadhesive nanoparticles (BNPs) in non‐human primates. We additionally examined
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Therapeutic potential and impact of nanoengineered patient‐derived mesenchymal stem cells in a murine resection and recurrence model of human glioblastoma Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-08 Rawan Al‐Kharboosh, Alex Bechtle, Stephany Y. Tzeng, Jiaying Zheng, Sujan Kumar Mondal, David R. Wilson, Carlos Perez‐Vega, Jordan J. Green, Alfredo Quiñones‐Hinojosa
Confounding results of engineered mesenchymal stem cells (MSCs) used as cellular vehicles has plagued technologies whereby success or failure of novel approaches may be dismissed or inaccurately ascribed solely to the biotechnology platform rather than suitability of the human donor. Polymeric materials were screened for non‐viral engineering of MSCs from multiple human donors to deliver bone morphogenic
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Antibody drug conjugates in the clinic Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-04 Edidiong Udofa, Disha Sankholkar, Samir Mitragotri, Zongmin Zhao
Antibody‐drug conjugates (ADCs), chemotherapeutic agents conjugated to an antibody to enhance their targeted delivery to tumors, represent a significant advancement in cancer therapy. ADCs combine the precise targeting capabilities of antibodies and the potent cell‐killing effects of chemotherapy, allowing for enhanced cytotoxicity to tumors while minimizing damage to healthy tissues. Here, we provide
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A stretchable, electroconductive tissue adhesive for the treatment of neural injury Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-03 Jharana Dhal, Mahsa Ghovvati, Avijit Baidya, Ronak Afshari, Curtis L. Cetrulo, Reza Abdi, Nasim Annabi
Successful nerve repair using bioadhesive hydrogels demands minimizing tissue–material interfacial mechanical mismatch to reduce immune responses and scar tissue formation. Furthermore, it is crucial to maintain the bioelectrical stimulation‐mediated cell‐signaling mechanism to overcome communication barriers within injured nerve tissues. Therefore, engineering bioadhesives for neural tissue regeneration
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Hemostats in the clinic Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-05-01 Maithili Joshi, Zongmin Zhao, Samir Mitragotri
Given the prevalence of hematological conditions, surgeries, and trauma incidents, hemostats—therapeutics designed to control and arrest bleeding—are an important tool in patient care. The prophylactic and therapeutic use of hemostats markedly enhances survival rates and improves the overall quality of life of patients suffering from these conditions. Since their inception in the 1960s, hemostats have
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Implantable and transcutaneous photobiomodulation promote neuroregeneration and recovery of lost function after spinal cord injury Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-26 Andrew R. Stevens, Mohammed Hadis, Alice Phillips, Abhinav Thareja, Michael Milward, Antonio Belli, William Palin, David J. Davies, Zubair Ahmed
Spinal cord injury (SCI) is a cause of profound and irreversible damage, with no effective therapy to promote functional recovery. Photobiomodulation (PBM) may provide a viable therapeutic approach using red or near‐infrared light to promote recovery after SCI by mitigating neuroinflammation and preventing neuronal apoptosis. Our current study aimed to optimize PBM dose regimens and develop and validate
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Model acetylcholinesterase‐Fc fusion glycoprotein biotechnology system for the manufacture of an organophosphorus toxicant bioscavenging countermeasure Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-26 Thomas G. Biel, Talia Faison, Alicia M. Matthews, Uriel Ortega‐Rodriguez, Vincent M. Falkowski, Edward Meek, Xin Bush, Matthew Flores, Sarah Johnson, Wells W. Wu, Mari Lehtimaki, Rong‐Fong Shen, Cyrus Agarabi, V. Ashutosh Rao, Janice E. Chambers, Tongzhong Ju
Organophosphate (OP) toxicants remain an active threat to public health and to warfighters in the military. Current countermeasures require near immediate administration following OP exposure and are reported to have controversial efficacies. Acetylcholinesterase (AChE) fused to the human immunoglobulin 1 (IgG1) Fc domain (AChE‐Fc) is a potential bioscavenger for OP toxicants, but a reproducible AChE‐Fc
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Eye of the future: Unlocking the potential utilization of hydrogels in intraocular lenses Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-24 Hao Wu, Jiale Wang, Wenhui Fan, Qi Zhong, Rongyue Xue, Siyu Li, Zongming Song, Ye Tao
Hydrogels are distinguished by their exceptional ability to absorb and retain large volumes of water within their complex three‐dimensional polymer networks, which is advantageous for the development of intraocular lenses (IOLs). Their innate hydrophilicity offers an optimal substrate for the fabrication of IOLs that simulate the natural lens' accommodation, thereby reducing irritation and facilitating
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Tissue‐engineered tracheal implants: Advancements, challenges, and clinical considerations Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-22 Shixiong Wei, Yiyuan Zhang, Feixiang Luo, Kexing Duan, Mingqian Li, Guoyue Lv
Restoration of extensive tracheal damage remains a significant challenge in respiratory medicine, particularly in instances stemming from conditions like infection, congenital anomalies, or stenosis. The trachea, an essential element of the lower respiratory tract, constitutes a fibrocartilaginous tube spanning approximately 10–12 cm in length. It is characterized by 18 ± 2 tracheal cartilages distributed
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Two‐pronged reversal of chemotherapy resistance by gold nanorods induced mild photothermal effect Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-18 Qi Shang, Ziyan Chen, Jing Li, Mingmei Guo, Jiapei Yang, Zhu Jin, Yuanyuan Shen, Shengrong Guo, Feihu Wang
Chemotherapy treatment outcomes are severely restricted by multidrug resistance (MDR), in which tumors develop a multiple cross‐resistance toward drug involving the pump and nonpump resistance mechanisms, resulting in drug efflux and defending against drug toxicity. Herein, we constructed a pH and near infrared (NIR) light responsive nanomedicine DOX@FG based on gold nanorods (GNRs) that demonstrated
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Nanomaterial‐assisted oncolytic bacteria in solid tumor diagnosis and therapeutics Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-17 Xiangdi Zeng, Qi Chen, Tingtao Chen
Cancer presents a formidable challenge in modern medicine due to the intratumoral heterogeneity and the dynamic microenvironmental niche. Natural or genetically engineered oncolytic bacteria have always been hailed by scientists for their intrinsic tumor‐targeting and oncolytic capacities. However, the immunogenicity and low toxicity inevitably constrain their application in clinical practice. When
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Dissolved gases from pressure changes in the lungs elicit an immune response in human peripheral blood Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-17 Abigail G. Harrell, Stephen R. Thom, C. Wyatt Shields
Conventional dogma suggests that decompression sickness (DCS) is caused by nitrogen bubble nucleation in the blood vessels and/or tissues; however, the abundance of bubbles does not correlate with DCS severity. Since immune cells respond to chemical and environmental cues, we hypothesized that the elevated partial pressures of dissolved gases drive aberrant immune cell phenotypes in the alveolar vasculature
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Versatile tissue‐injectable hydrogels capable of the extended hydrolytic release of bioactive protein therapeutics Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-15 Eric S. Nealy, Steven J. Reed, Steven M. Adelmund, Barry A. Badeau, Jared A. Shadish, Emily J. Girard, Kenneth Brasel, Fiona J. Pakiam, Andrew J. Mhyre, Jason P. Price, Surojit Sarkar, Vandana Kalia, Cole A. DeForest, James M. Olson
Hydrogels are extensively employed in healthcare due to their adaptable structures, high water content, and biocompatibility, with FDA‐approved applications ranging from spinal cord regeneration to local therapeutic delivery. However, clinical hydrogels encounter challenges related to inconsistent therapeutic exposure, unmodifiable release windows, and difficulties in subsurface polymer insertion.
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Spatiotemporal evolutionary process of osteosarcoma immune microenvironment remodeling and C1QBP‐driven drug resistance deciphered through single‐cell multi‐dimensional analysis Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-11 Wu Xin, Ning Tang, Qiangqiang Zhao, Jianbin Xiong
The tumor immune microenvironment has manifested a crucial correlation with tumor occurrence, development, recurrence, and metastasis. To explore the mechanisms intrinsic to osteosarcoma (OS) initiation and progression, this study synthesizes multiple single‐cell RNA sequencing data sets, constructing a comprehensive landscape of the OS microenvironment. Integrating single‐cell RNA sequencing with
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Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-09 Jose Miguel Flores‐Fernandez, Verena Pesch, Aishwarya Sriraman, Enrique Chimal‐Juarez, Sara Amidian, Xiongyao Wang, Caleb Duckering, Andrew Fang, Sara Reithofer, Liang Ma, Leonardo M. Cortez, Valerie L. Sim, Gültekin Tamgüney, Holger Wille
Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha‐synuclein protein. Developing effective vaccines against synucleinopathies is challenging due to the difficulty of stimulating an immune‐specific response against alpha‐synuclein without causing harmful
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A double‐edged sword: The complex interplay between engineered nanoparticles and platelets Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-06 Yathreb Asaad, Danielle Nemcovsky‐Amar, Josué Sznitman, Pierre H. Mangin, Netanel Korin
Nanoparticles (NP) play a crucial role in nanomedicine, serving as carriers for localized therapeutics to allow for precise drug delivery to specific disease sites and conditions. When injected systemically, NP can directly interact with various blood cell types, most critically with circulating platelets. Hence, the potential activation/inhibition of platelets following NP exposure must be evaluated
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Ultrasound inhibits tumor growth and selectively eliminates malignant brain tumor in vivo Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-04-02 Nitsa Buaron, Antonella Mangraviti, Yuan Wang, Ann Liu, Mariangela Pedone, Eric Sankey, Itay Adar, Abraham Nyska, Riki Goldbart, Tamar Traitel, Henry Brem, Betty Tyler, Joseph Kost
Glioma is one of the most common primary malignant brain tumors. Despite progress in therapeutic approaches, the median survival of patients with glioma remains less than 2 years, generating the need for new therapeutic approaches. Ultrasound (US) is widely used in medical fields and is used as a therapeutic tool mainly for improving the performance of therapeutic entities. In this study, we examined
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Development of a novel glucose‐dendrimer based therapeutic targeting hyperexcitable neurons in neurological disorders Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-03-27 Anjali Sharma, Nirnath Sah, Rishi Sharma, Preeti Vyas, Wathsala Liyanage, Sujatha Kannan, Rangaramanujam M. Kannan
Neuronal hyperexcitability and excitotoxicity lies at the core of debilitating brain disorders such as epilepsy and traumatic brain injury, culminating in neuronal death and compromised brain function. Overcoming this challenge requires a unique approach that selectively restores normal neuronal activity and rescues neurons from impending damage. However, delivering drugs selectively to hyperexcitable
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Vaccine adjuvants for infectious disease in the clinic Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-03-22 Morgan Goetz, Naaz Thotathil, Zongmin Zhao, Samir Mitragotri
Adjuvants, materials added to vaccines to enhance the resulting immune response, are important components of vaccination that are many times overlooked. While vaccines always include an antigen to tell the body what to vaccinate to, of equal importance the adjuvant provides the how, a significant factor in producing a complete response. The adjuvant space has been slow to develop with the first use
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Human induced pluripotent stem cells‐derived liver organoids grown on a Biomimesys® hyaluronic acid‐based hydroscaffold as a new model for studying human lipoprotein metabolism Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-03-16 Meryl Roudaut, Amandine Caillaud, Zied Souguir, Lise Bray, Aurore Girardeau, Antoine Rimbert, Mikaël Croyal, Gilles Lambert, Murielle Patitucci, Gaspard Delpouve, Élodie Vandenhaute, Cédric Le May, Nathalie Maubon, Bertrand Cariou, Karim Si‐Tayeb
The liver plays a key role in the metabolism of lipoproteins, controlling both production and catabolism. To accelerate the development of new lipid‐lowering therapies in humans, it is essential to have a relevant in vitro study model available. The current hepatocyte‐like cells (HLCs) models derived from hiPSC can be used to model many genetically driven diseases but require further improvement to
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Tolerability of a piezoelectric microneedle electroporator in human subjects Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-03-15 Chao‐Yi Lu, Pankaj Rohilla, Eric I. Felner, Gaurav Byagathvalli, Erkan Azizoglu, M. Saad Bhamla, Mark R. Prausnitz
Electroporation, or the use of electric pulses to facilitate the intracellular delivery of DNA, RNA, and other molecules, is a well‐established technique, that has been demonstrated to significantly augment the immunogenicity of DNA/mRNA vaccines and therapeutics. However, the clinical translation of traditional electroporators has been limited due to high costs, large size, complex user operation
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Evaluation of a novel vaginal cells self‐sampling device for human papillomavirus testing in cervical cancer screening: A clinical trial assessing reliability and acceptability Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-03-13 Chung‐Yao Yang, Ting‐Chang Chang, Hung‐Hsueh Chou, Angel Chao, Shih‐Tien Hsu, Yu‐Hsiang Shih, Huei‐Jean Huang, Cheng‐Tao Lin, Min‐Yu Chen, Lou Sun, Kuan‐Gen Huang, Kai‐Yun Wu, Wu‐Chiao Hsieh, Yi‐Ting Huang, Liang‐Hsuan Chen, Chien‐Hsing Lu, Hao Lin, Chao‐Min Cheng
Cervical cancer is a significant public health concern, particularly in low‐ and middle‐income countries where resources for prevention and treatment are limited. Routine screening, such as the Papanicolaou test (Pap smears) and human papillomavirus (HPV) testing, plays a crucial role in the early detection and prevention of cervical cancer. However, the participation rate in cervical cancer screening
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Synchronously in vivo real‐time monitoring bacterial load and temperature with evaluating immune response to decipher bacterial infection Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-03-13 Huaixuan Sheng, Huizhu Li, Shunyao Li, Chengxuan Yu, Yueming Wang, Haichen Hu, Lu Fang, Fuchun Chen, Yanyan Lu, Xiaogang Xu, Xing Yang, Shiyi Chen, Yuefeng Hao, Yunxia Li, Sijia Feng, Jun Chen
Determining the precise course of bacterial infection requires abundant in vivo real‐time data. Synchronous monitoring of the bacterial load, temperature, and immune response can satisfy the shortage of real‐time in vivo data. Here, we conducted a study in the joint‐infected mouse model to synchronously monitor the bacterial load, temperature, and immune response using the second near‐infrared (NIR‐II)
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Siglec15/TGF‐β bispecific antibody mediates synergistic anti‐tumor response against 4T1 triple negative breast cancer in mice Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-03-12 Limei Shen, Alison M. Schaefer, Karthik Tiruthani, Whitney Wolf, Samuel K. Lai
An ideal tumor‐specific immunomodulatory therapy should both preferentially target the tumor, while simultaneously reduce the immunosuppressive environment within the tumor. This guiding principle led us to explore engineering Siglec‐15 (S15) targeted bispecific antibody (bsAb) to enhance therapy against triple negative breast cancer (TNBC). S15 appears to be exclusively expressed on macrophages and
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Correction to “Primary T‐cell‐based delivery platform for in vivo synthesis of engineered proteins” Bioeng. Transl. Med. (IF 6.1) Pub Date : 2024-03-11
Radhakrishnan H, Newmyer SL, Ssemadaali MA, Javitz HS, Bhatnagar P. Primary T-cell-based delivery platform for in vivo synthesis of engineered proteins. Bioeng Transl Med. 2024; 9(1):e10605. doi:10.1002/btm2.10605 Unlike the remainder of the manuscript where the data have been developed using pan CD3 T cells, Figure 4d–f used CD4 T cells. We apologize for this error. Corrections have been disclosed