Objective To quantify the burden of ocular injuries on deployed United States service members by calculating Disability Adjusted Life Years (DALYs). Design Retrospective, observational cohort study Subjects US service members with ocular injuries sustained in combat zones from 2001-2020 Methods Using data from the Defense and Veterans Eye Injury and Vision Registry (DVEIVR), health states and duration

TOPIC Review of the efficacy and safety of standard versus soft topical steroid application after cataract surgery. CLINICAL RELEVANCE The control of postoperative inflammation is the mainstay of post-cataract surgery treatment. However, no consensus exists regarding the postoperative steroid of choice. Basing the choice of topical postoperative steroidal treatment on high-quality data regarding both

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Purpose Patients with incurable corneal diseases experience visual impairment despite having a healthy retina and optic pathway. Low vision aids (LVAs) are prescribed to optimize the use of remaining vision through magnification and contrast enhancement, but do not fully utilize the patient's visual capacity since they rely on the optic media. Therefore, we investigated a novel laser-eyewear (LEW)

Purpose To investigate if the interval between diagnosis and treatment of posterior uveal melanoma is associated with metastatic death. Design Retrospective, single-center cohort study. Subjects 1145 patients consecutively diagnosed with posterior uveal melanoma at St. Erik Eye Hospital, Stockholm, from 2012 to 2022, with recorded dates of diagnosis and primary treatment. This cohort represents 81%

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Purpose To evaluate the ultra-widefield fundus photography (UWF-FP)-guided swept-source optical coherence tomography (SS-OCT) images of peripheral vitreoretinal abnormality (PVRA) in young asymptomatic myopes. Design Cross-sectional, single-center study. Participants 1,966 eyes of 983 consecutive patients aged 18–42 years with refractive error in the spherical equivalent of <0 diopters who visited

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Purpose The purpose of this study was to assess the safety, tolerability, and potential efficacy of topical elamipretide in patients affected with Leber’s Hereditary Optic Neuropathy (LHON). Design This Phase 2, prospective, randomized, vehicle controlled, single-center clinical trial involved administration of elamipretide (MTP-131) topical ophthalmic solution to LHON patients over a 52-week double-masked

Purpose To evaluate the influence of a capsular tension ring (CTR) on rotational stability, decentration, tilt and axial stability of a 11.0mm plate haptic intraocular lens (IOL) Design Intraindividual, randomized, double masked, controlled, clinical trial. Participants Patients scheduled for sequential same day bilateral cataract surgery. Methods All patients were randomized to receive a CTR and a

Purpose To independently validate the retinal detachment (RD) after open globe injury (OGI) score (RD-OGI Score) as a clinical prediction model for estimating the risk of RD after OGI, and to characterize outcomes of RD stratified by RD-OGI risk category. Design Retrospective, multi-institutional cohort study. Subjects A validation cohort of 236 eyes with OGI managed at two U.S. academic institutions

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Purpose The current, 8th Edition, of the American Joint Committee on Cancer (AJCC) anatomic classification and staging model for uveal melanoma does not fully separate survival estimates for patients in advanced stages of the disease (e.g., IIIB and IIIC). Furthermore, some tumors in higher size categories have a smaller volume than tumors in lower categories. Therefore, we develop a novel model for

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Purpose To review the published literature on the diagnostic capabilities of the newest generation of corneal imaging devices for the identification of keratoconus. Methods Corneal imaging devices studied included tomographic platforms (Scheimpflug photography, OCT) and functional biomechanical devices (imaging an air impulse on the cornea). A literature search in the PubMed database for English language

Purpose To assess risk factors for worse visual acuity (VA) outcomes after intraocular lens (IOL) exchange, and the most common postsurgical complications. Design Retrospective cohort study. Subjects Eyes from patients aged 18 years and older in the IRIS® Registry (Intelligent Research in Sight) that underwent IOL exchange in the United States between 2013 and 2019. Methods VA improvement compared

Purpose To assess the duration, incidence, reversibility, and severity of adverse events (AEs) in patients with thyroid eye disease (TED) treated with teprotumumab. Design Multi-center retrospective observational cohort study. Participants Patients with TED of all stages and activity levels treated with at least 4 infusions of teprotumumab. Methods Patients were treated with teprotumumab between February

Purpose To assess the web accessibility and readability of patient-oriented educational websites for cataract surgery. Design Cross-sectional electronic survey. Subjects Websites with information dedicated to educating patients about cataract surgery. Methods An incognito search for “cataract surgery” was performed using a popular search engine. The top 100 patient-oriented cataract surgery websites

Objective To compare population demographics with the geographic distribution of oculofacial plastic surgeons (OPS) in the United States (US). Design A cross-sectional study design was employed to investigate demographic differences between counties with one or more OPS and counties with zero OPS. Participants The number of OPS were identified in each US County using online public databases – American

We describe the results of two surveys about diagnostic odyssey assessing over 1000 patients with inherited retinal diseases. Younger patients, those who attended multiple visits, and those given different diagnoses, faced longer diagnostic delay.

Purpose Glaucoma is a heterogeneous group of optic neuropathies that potentially may be associated with other cerebral neurodegenerative processes leading to dementia. However, prior studies have been inconsistent. We examined dementia risks following glaucoma diagnosis in a large population-based cohort. Design National matched cohort study. Participants 324,730 persons diagnosed with glaucoma during

Purpose To characterize focal biomechanical alterations in subclinical keratoconus (SKC) using motion tracking (MT) Brillouin microscopy and evaluate the ability of MT Brillouin metrics to differentiate SKC eyes from normal controls. Design Prospective cross-sectional study Participants Thirty eyes from 30 patients were evaluated, including 15 eyes from 15 bilaterally normal patients and 15 SKC eyes

Purpose To describe the clinical presentation and treatment outcomes of children diagnosed with retinoblastoma (RB) in the year 2017, throughout Asia. Design Multi-national prospective study including treatment-naïve patients diagnosed with retinoblastoma in Asia during 2017 and followed up thereafter. Participants A total of 2112 patients (2797 eyes) from 96 RB treatment centers in 33 Asian countries

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Purpose To assess the risk of dementia in individuals with newly diagnosed ocular motor cranial neuropathy (OMCN). Design A nationwide, population-based cohort study using authenticated data from the Korean National Health Insurance Service (KNHIS). Subjects This study included 60,781 OMCN patients diagnosed between 2010 and 2017 and followed through 2018, with an average follow-up of 3.37 (SD, 2.21)

We classified drug-induced uveitis related to Immune Checkpoint inhibitors (ICIs) and MAP-kinase pathway inhibitors (MAPKi), including BRAF-inhibitors (BRAFi) and MEK-inhibitors (MEKi), according ophthalmological examination. Cases were retrieved from the French pharmacovigilance database (FPVD) which included all adverse drug reactions (ADR) registred by the French Regional Pharmacovigilance Network

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Objectives To compare topical PHMB (polihexanide) 0.02% (0.2 mg/ml) + propamidine 0.1% (1 mg/ml) [PHMB 0.02%+propamidine] to PHMB 0.08% (0.8 mg/ml) with placebo [PHMB 0.08%] for Acanthamoeba keratitis (AK) treatment. Design Prospective randomized, double-masked, active-controlled, multicentre, Phase3 study (ClinicalTrials.gov NCT03274895). Participants 135 at six European centres between 08/17/2017

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Surgical outcomes of bilateral horizontal rectus recession surgeries performed by a single surgeon using absorbable compared to non-absorbable sutures. The use of non-absorbable sutures in a novel technique reduces overcorrection compared to absorbable sutures use.

Purpose Private equity (PE) firms are increasingly acquiring ophthalmology practices; little is known of their influence on care utilization and spending. We studied changes in utilization and Medicare spending after PE acquisition. Design Retrospective cohort study. Participants 762 clinicians in 123 practices acquired by PE between 2017 and 2018; 34,807 clinicians in 20,549 never-acquired practices

Purpose To compare the effectiveness and safety of the MicroShunt (Santen Inc., Emeryville, CA, USA) versus trabeculectomy in patients with primary open-angle glaucoma (POAG). Design Prospective, randomized, multicenter trial conducted in the United States and Europe. Participants Adult patients (aged 40-85 years) with mild to severe POAG inadequately controlled on maximum tolerated medical therapy

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