Objective To compare visual field outcomes of ocular hypertensive and glaucoma patients treated with Medicine-1st against those treated with selective laser trabeculoplasty (SLT, Laser-1st). Design Secondary analysis of patients from Laser in Glaucoma and Ocular Hypertension (LiGHT), a multicentre randomised controlled trial. Participants and controls 344 patients (588 eyes) treated with Medicine-1st

Purpose To evaluate the efficacy and safety of intravitreal sirolimus in the management of noninfectious uveitis of the posterior segment (NIU-PS). Design Combined analysis of two phase III, randomized, double-masked, multinational, 6-month studies (SAKURA Program). Participants Adults with active NIU-PS (intermediate, posterior, or panuveitis; defined as vitreous haze [VH] ≥ 1.5+ on modified Standardization

Use of the flanged intrascleral haptic fixation technique for insertion of an intraocular lens in the setting of lost capsular support provides predictable refractive outcomes and is a promising alternative to anterior chamber intraocular lenses.

Objective Identify baseline risk factors for macular atrophy (MA) development in the HARBOR trial population via a longitudinal assessment of monthly spectral-domain optical coherence tomography (SD-OCT) scans. Previous analyses of MA in HARBOR examined data from color fundus photography (CFP)/fluorescein angiography (FA). Design Retrospective, post hoc analysis of SD-OCT images from HARBOR (NCT00891735)

Retinal hyper-reflective foci (HRF), supposed to reflect microglial activity and never investigated in Multiple Sclerosis (MS) before, were found significantly increased in the inner retina of early relapsing MS compared to healthy controls (p<0.0001).

OBJECTIVE Evaluation of glaucoma progression with optical coherence tomography (OCT) has been centered on the analysis of progressive retinal nerve fiber layer (RNFL) thinning over the parapapillary region and/or progressive ganglion cell inner plexiform layer (GCIPL) thinning over the macula. We investigated (1) whether combining the RNFL and GCIPL as a single layer (i.e. RNFL-GCIPL) for wide-field

Purpose Assess follow-up treatment and clinical outcomes at 5 years in eyes initially treated with anti-VEGF therapy for center involved diabetic macular edema (CI-DME) in a 2-year randomized clinical trial. Design Multicenter cohort study. Participants Participants with DME and visual acuity (VA) 20/32 to 20/320 enrolled in DRCR.net Protocol T with visits 5 years after randomization (3 years after

Purpose To describe visual outcomes, frequency of treatment and monitoring visits, and anti-vascular endothelial growth factor drugs used in usual care in participants who exited a trial in which treatment for neovascular age-related macular degeneration (nAMD) was initiated with bevacizumab or ranibizumab. Design Multi-centre cohort study up to 7 years after trial exit. Participants Patients enrolled

Ocular transmission of COVID-19 is uncertain. 64 tear samples were collected from 17 COVID-19 patients between Day 3 to Day 20 from initial symptoms. Neither viral culture nor reverse transcription polymerase chain reaction (RT-PCR) detected the virus, suggesting a low risk of ocular transmission.

This article has been retracted: please see Elsevier policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). The editors wish to note that concerns were raised regarding coding errors in the data set that formed the basis of this study. Patient record numbers were found to be duplicated, so that the number of endophthalmitis cases was unclear as was the

Intralesional rituximab for low-grade conjunctival lymphoma provided complete response in 11(73%) eyes and partial response in 4(27%) eyes after 37-month(range,6-84) mean follow-up. Side effects were periocular swelling in 1 and allergic reaction in 2 patients.

Purpose Anti-VEGF treatment of neovascular age-related macular degeneration (AMD) is a highly effective advance in the retinal armentarium. Optical coherence tomography (OCT) offering three-dimensional imaging of the retina is widely used to guide treatment. Although poor outcomes reported from clinical practice are multifactorial, availability of reliable, reproducible, and quantitative evaluation

Purpose To develop an artificial intelligence (AI) dashboard for monitoring glaucomatous functional loss. Design Retrospective, cross-sectional and longitudinal cohort study. Participants Out of 31,591 visual fields (VFs) on 8,077 subjects, 13,231 VFs from the most recent visit of each patient were included to develop the AI dashboard. Longitudinal VFs from 287 eyes with glaucoma were used to validate

Objective Anatomically similar rhegmatogenous retinal detachments (RRDs) can be treated with scleral buckle (SB), pars plana vitrectomy (PPV), or scleral buckle combined with vitrectomy (PPV/SB). This study compares moderately complex phakic primary RRD treated with SB, PPV, or PPV/SB to review anatomic and visual outcomes. Design Multicenter, retrospective, interventional cohort study. Subjects, Participants

Deep orbital dermoid cysts present late, often with inflammatory episodes -- the latter leading to fibrosis and impairment of orbital functions. Being curative, complete excision is recommended and can usually be performed without mobilization of bone.

Objective/ Purpose Appropriate correction of aphakia is key to good outcomes. There may be clinical settings and populations where accessing or managing aphakic contact lenses is challenging. Strategies to target the increased risk of visual axis opacity (VAO) following primary IoL implantation in infancy are necessary. We describe the predictors of VAO following primary IoL implantation for unilateral

Purpose To describe visual field outcomes in the Tube Versus Trabeculectomy (TVT) Study. Design Cohort analysis of patients in a multicenter randomized clinical trial. Participants One hundred twenty-two eyes of 122 patients, with 61 eyes in both the tube shunt and trabeculectomy groups. Methods The TVT Study is a multicenter randomized clinical trial comparing the safety and efficacy of tube shunt

Purpose To report the 3 month results of a randomised trial (FACT) comparing femtosecond laser assisted cataract surgery (FLACS) and standard phacoemulsification cataract surgery (PCS). Design Multicentre, randomized controlled trial funded by the UK National Institute of Health Research (NIHR, HTA 13/04/46/) Methods This trial took place in three hospitals in the UK National Health Service (NHS).

Objective To compare best spectacle-corrected visual acuity (BSCVA), endothelial cell density (ECD), refractive astigmatism, and complications after Descemet membrane endothelial keratoplasty (DMEK) and ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK). Design Prospective, multicenter randomized controlled trial. Participants Fifty-four pseudophakic eyes of 54 patients with

Purpose To assess anti-vascular endothelial growth factor (VEGF) management patterns and anatomic and visual acuity outcomes among patients with neovascular age-related macular degeneration (nAMD) in US clinical practice. Design Retrospective observational cohort study. Subjects 30,106 patients (37,021 study eyes) initiating intravitreal anti-VEGF treatment for nAMD between October 2009 and November

Purpose This study investigates the prevalence of manifest strabismus and its subtypes in adulthood and analyses risk factors. The impact of strabismus on vision-related quality of life in the general population is examined. Design The Gutenberg Health Study (GHS) is a population-based, observational cohort study. A cross-sectional analysis of the baseline examination was conducted. Study subjects

Objective To examine the relationship between dementia status and receipt of eye care among US Medicare beneficiaries. Design Retrospective claims-based analysis Participants A 20% representative sample of Medicare beneficiaries who received care between January 1, 2006, and December 31, 2015. Methods Dementia was identified from diagnosis codes documented in a beneficiary’s first 3 years of observed

The rAAV2-ND4 gene therapy that targets mt11778G>A was delivered to nine patients with Leber’s hereditary optic neuropathy (LHON) and continues to be safe and potentially effective at long-term (75–90 months) follow-up.

Objective Loss of photoreceptors in atrophic age-related macular degeneration results in severe visual impairment, although some peripheral vision is retained. To restore central vision without compromising the residual peripheral field, we developed a wireless photovoltaic retinal implant (PRIMA), in which pixels convert images projected from video glasses using near-infrared light, into electric

PURPOSE To characterize surgical confusions in ophthalmology to determine their incidence, root causes, and impact on patients and physicians. DESIGN Retrospective cohort study of errors in ophthalmic surgical procedures between January 1, 2006, and December 31, 2017. PARTICIPANTS One hundred forty-three cases involving surgical confusions. METHODS Cases were identified by the Ophthalmic Mutual Insurance

Many ophthalmology residents struggle with the acquisition of surgical skills, but a large majority are successfully remediated before graduation using supportive measures and modern ophthalmic surgical training.

Purpose To investigate the difference in longitudinal change of beta-zone parapapillary atrophy (ß-zone PPA) between primary open-angle glaucoma (POAG) and normal eyes. Design Longitudinal, observation study Participants 153 eyes with POAG and 105 normal eyes Methods Participants were followed for 10 years or longer, with disc photography performed every year. The topographic parameters of ß-zone PPA

Purpose To develop and validate a deep learning model for the automatic segmentation of geographic atrophy (GA) in color fundus images (CFIs) and its application to study growth rate of GA. Design Prospective, multicenter, natural history study with up to 15 years of follow up. Participants 409 CFIs of 238 eyes with GA from the Rotterdam Study (RS) and the Blue Mountain Eye Study (BMES) for model development

This case series describes 34 patients presenting with facial injuries after standing electric scooter use at two academic emergency departments, 6/2018-5/2019. The severity of injuries highlights this important emerging health risk and policy implications.

Purpose To examine the normative profile and determinants of macular ganglion cell-inner plexiform layer (GCIPL) thickness based on spectral-domain OCT (SD-OCT) in a non-glaucoma, multi-ethnic Asian population. Design Population-based, cross-sectional study. Participants Ethnic Chinese, Malay and Indian adults, aged ≥40 years, recruited from the Singapore Epidemiology of Eye Diseases Study. Methods

Objective Although the impact of vision-related quality of life (VRQoL) is optimally assessed using binocular visual acuity (VA), uniocular VA remains the preferred measurement modality in clinic-based and epidemiological studies. We compared the impact of distance presenting binocular VA and uniocular VA in the better seeing (better-eye VA) and worse seeing (worse-eye VA) eye on VRQoL. Design The

Purpose To investigate the change in the prevalence of reduced visual acuity (VA) in Taiwanese schoolchildren after a policy intervention promoting increased time outdoors. Design A prospective cohort study based on the Taiwan School Student Visual Acuity Screen (TSVAS) by the Ministry of Education in Taiwan. Participants All schoolchildren from grades 1–6 were enrolled in the TSVAS from 2001 to 2015

Purpose Aggressive posterior retinopathy of prematurity (AP-ROP) is a vision-threatening disease with a significant rate of progression to retinal detachment. The purpose of this study was to quantitatively characterize AP-ROP by demographics, rate of disease progression, and a deep learning based vascular severity score. Design Retrospective analysis Subjects The Imaging and Informatics in ROP (i-ROP)

Objective In this study, we assess the diagnostic performance and generalizability of logistic regression in classifying primary vitreoretinal lymphoma (PVRL) vs. uveitis from intraocular cytokine levels in a single-center retrospective cohort, comparing a logistic regression model and the previously published ISOLD score against the IL-10/IL-6 ratio. Design Retrospective cohort study Participants

Adults in South India randomized to a 5-year course of antioxidant vitamins or placebo had similar rates of self-reported cataract surgery 15 years later (16% in the vitamin group versus 15% in the placebo group).

Purpose To determine the cost-effectiveness of an adjunctive screening optical coherence tomography (OCT) in the preoperative evaluation of a patient considering cataract surgery with a multifocal intraocular lens (IOL) implantation. Design Cost-effectiveness analysis (CEA) Subject The base case was a 67-year old male with 20/60 vision undergoing evaluation for a first eye cataract surgery. Methods

We report the first real-world analysis of AAO’s IRIS50 outcome measures, evaluating 1817 amblyopia patients and comparing with IRIS7. Of 238 patients meeting inclusion criteria, 81% were successful. No variables independently correlated with success.

Purpose Type 1 macular neovascularization (MNV) secondary to age-related macular degeneration (AMD) may compensatorily sustain hypoxic and micronutrient-insufficient outer retinal cells. We explored this hypothesis via histology of an eye with a shallow irregular retinal pigment epithelial elevation (SIRE) on optical coherence tomography (OCT) and good vision. Design Case study and clinicopathologic

PURPOSE To compare early postoperative intraocular pressure (IOP) in patients who underwent cataract surgery alone with those who underwent cataract surgery combined with implantation of a Hydrus Microstent (HMS) (Ivantis, Irvine, CA). DESIGN Subanalysis of data from the randomized controlled HORIZON trial, a multicenter trial including 26 US and 12 international sites. PARTICIPANTS Participants with