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Genetic Deletion of Galectin-3 Inhibits Pancreatic Cancer Progression and Enhances the Efficacy of Immunotherapy Gastroenterology (IF 29.4) Pub Date : 2024-03-11 Daowei Yang, Xinlei Sun, Rohan Moniruzzaman, Hua Wang, Citu Citu, Zhongming Zhao, Ignacio I. Wistuba, Huamin Wang, Anirban Maitra, Yang Chen
Pancreatic ductal adenocarcinoma (PDAC) has a desmoplastic tumor stroma and immunosuppressive microenvironment. Galectin-3 (GAL3) is enriched in PDAC, highly expressed by cancer cells and myeloid cells. However, the functional roles of GAL3 in the PDAC microenvironment remain elusive. We generated a novel transgenic mouse model (KPPC;Lgals3) that allows the genetic depletion of GAL3 from both cancer
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Biopsy proteome scoring to determine mucosal remodeling in celiac disease Gastroenterology (IF 29.4) Pub Date : 2024-03-11 Anette Johansen, Geir Kjetil F. Sandve, Jostein Holen Ibsen, Knut E.A. Lundin, Ludvig M. Sollid, Jorunn Stamnaes
Histological evaluation of gut biopsies is a cornerstone for diagnosis and management of celiac disease (CeD). Despite its wide use, the method depends on proper biopsy orientation, and it suffers from inter-observer variability. Biopsy proteome measurement reporting on tissue state can be obtained by mass spectrometry (MS) analysis of formalin-fixed paraffin embedded (FFPE) tissue. Here we aimed to
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THORACOABDOMINAL WALL MOTION-GUIDED BIOFEEDBACK TREATMENT OF ABDOMINAL DISTENSION: A RANDOMIZED PLACEBO-CONTROLLED TRIAL Gastroenterology (IF 29.4) Pub Date : 2024-03-11 Elizabeth Barba M.D., Dan M. Livovsky M.D., Anna Accarino M.D., Fernando Azpiroz M.D.
Abdominal distention results from abdominophrenic dyssynergia (diaphragmatic contraction and abdominal wall relaxation) in patients with disorders of the gut-brain interaction. This study aimed to validate a simple biofeedback procedure, guided by abdominothoracic wall motion, for treating abdominal distension. In this randomized, parallel, placebo-controlled trial, 42 consecutive patients (36 women
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A Baby Step or a Real Giant Stride: Histomic Enabled by Artificial Intelligence to Predict Treatment Response in Pediatric Patients with Ulcerative Colitis Gastroenterology (IF 29.4) Pub Date : 2024-03-07 Marietta Iacucci, Yasuharu Maeda, Subrata Ghosh
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How Close is Close Enough? Improving Observational Study Design to Compare the Effectiveness of Health Interventions Gastroenterology (IF 29.4) Pub Date : 2024-03-07 S, a, n, j, a, y, , K, ., , M, u, r, t, h, y
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Celiac disease-related conditions: Who to test? Gastroenterology (IF 29.4) Pub Date : 2024-03-07 Fabiana Zingone, Julio C. Bai, Christophe Cellier, Jonas F. Ludvigsson
Celiac disease (CeD) is a chronic immune-mediated condition triggered by gluten consumption in genetically predisposed individuals. Approximately 1% of the general population is affected by the disorder. Disease presentation is heterogeneous, and despite growing awareness among physicians and the public, it continues to be underestimated. The most effective strategy for identifying undiagnosed CeD
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Colorectal tumor recurrence on a mysterious spot Gastroenterology (IF 29.4) Pub Date : 2024-03-06 D.A. Verhoeven BSc, A.S.L.P. Crobach MD PhD, J.J. Boonstra MD PhD
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Our New President—Maria T. Abreu, MD, AGAF Gastroenterology (IF 29.4) Pub Date : 2024-03-06 Uma Mahadevan, Marla Dubinsky, Iris Dotan
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A colorful conundrum: dark urine in a patient with inflammatory bowel disease Gastroenterology (IF 29.4) Pub Date : 2024-03-05 Stefan Mitev, Cvetelina Marinova, Zoya Spassova
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Sacral neural crest-independent origin of the enteric nervous system in mouse Gastroenterology (IF 29.4) Pub Date : 2024-03-05 Qi Yu, Li Liu, Mengjie Du, Daniel Müller, Yan Gu, Zhigang Gao, Xiaolong Xin, Yanlan Gu, Miao He, Till Marquardt, Liang Wang
The enteric nervous system (ENS), the gut’s intrinsic nervous system critical for gastrointestinal function and gut-brain communication, is believed to mainly originate from vagal neural crest cells (vNCCs) and partially from sacral NCCs (sNCCs). Resolving the exact origins of the ENS is critical for understanding congenital ENS diseases but has been confounded by the inability to distinguish between
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AGA Clinical Practice Update on Diagnosis and Management of Cannabinoid Hyperemesis Syndrome: Commentary Gastroenterology (IF 29.4) Pub Date : 2024-03-05 Alberto Rubio-Tapia, Richard McCallum, Michael Camilleri
The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update (CPU) is to review the available evidence and provide expert advice regarding diagnosis and management of cannabinoid hyperemesis syndrome. This CPU was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on
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Efficacy and findings of a blinded randomized reintroduction phase for the low FODMAP diet in Irritable Bowel Syndrome Gastroenterology (IF 29.4) Pub Date : 2024-02-23 K. Van den Houte, E. Colomier, K. Routhiaux, Z. Mariën, J. Schol, J. Van den Bergh, J. Vanderstappen, N. Pauwels, A. Joos, J. Arts, Ph. Caenepeel, F. De Clerck, C. Matthys, A. Meulemans, M. Jones, T. Vanuytsel, F. Carbone, J. Tack
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Spotlight: Use of Fecal Microbiota-Based Therapies in Adults With Select GI Disorders Gastroenterology (IF 29.4) Pub Date : 2024-02-21
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Consideration for Use of Fecal Microbiota-Based Therapies in Adults With GI Disorders Gastroenterology (IF 29.4) Pub Date : 2024-02-21
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Approaching Digestive Health Care in Transgender and Gender-Diverse Communities Gastroenterology (IF 29.4) Pub Date : 2024-02-21 Christopher Vélez, Kira L. Newman, Sonali Paul, Jens U. Berli, Vin Tangpricha, Laura E. Targownik
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AGA Clinical Practice Guideline on Fecal Microbiota–Based Therapies for Select Gastrointestinal Diseases Gastroenterology (IF 29.4) Pub Date : 2024-02-21 Anne F. Peery, Colleen R. Kelly, Dina Kao, Byron P. Vaughn, Benjamin Lebwohl, Siddharth Singh, Aamer Imdad, Osama Altayar
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CME Exam 1: PNPLA3 Risk Allele Association With ALT Response to Semaglutide Treatment Gastroenterology (IF 29.4) Pub Date : 2024-02-21
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In search of the best second-line therapy for Primary Biliary Cholangitis Gastroenterology (IF 29.4) Pub Date : 2024-02-20 Sabela Lens
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When aspirin causes damage - microbes modulate the host to restore gut homeostasis Gastroenterology (IF 29.4) Pub Date : 2024-02-20 Eytan Wine
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Metachronous Gastric Cancer Outcomes Following H-pylori Therapy after Endoscopic Dysplasia Resection: Insights from a Global Real-World Study Gastroenterology (IF 29.4) Pub Date : 2024-02-18 Yasutoshi Shiratori, Naoki Ishii, Anthony Kalloo
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A Commentary on the Epidemiology of Inflammatory Bowel Disease in Compounding Prevalence Nations: Towards Sustaining Healthcare Delivery Gastroenterology (IF 29.4) Pub Date : 2024-02-18 Michelle Herauf, Stephanie Coward, Juan-Nicolás Peña-Sánchez, Charles N. Bernstein, Eric I. Benchimol, Gilaad G. Kaplan
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Developing a Mentoring Network to Navigate Fellowship and Beyond: Moving From “Mentor” to “Mentors” Gastroenterology (IF 29.4) Pub Date : 2024-02-17 Kenzie A. Cameron, Terrance J. Rodrigues, Rajesh N. Keswani
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Thalidomide for Recurrent Small Intestinal Gastrointestinal Bleeding Gastroenterology (IF 29.4) Pub Date : 2024-02-17 Niranjani Venkateswaran
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Endoscopic Submucosal Dissection versus Endoscopic Mucosal Resection for Large Colonic Adenomas Gastroenterology (IF 29.4) Pub Date : 2024-02-17 Nauzer Forbes
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Reply to Zhang, Samo and Hamo, and Li and Yang Gastroenterology (IF 29.4) Pub Date : 2024-02-17 Johan Hardvik Åkerström, Giola Santoni, Jesper Lagergren
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Dysphagia In A 75-Year-Old Male Gastroenterology (IF 29.4) Pub Date : 2024-02-17 Michael A. Perrin, David Y. Graham, Scott A. Larson
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Esophageal Food Impaction - Cola Can’t Beat the Real Thing Gastroenterology (IF 29.4) Pub Date : 2024-02-17 Rena Yadlapati
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Reply to Deng et al Gastroenterology (IF 29.4) Pub Date : 2024-02-16 Fabio Casciani, Tommaso Pollini, Roberto Salvia
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In Human Esophageal Epithelial and Muscle Cells Treated with Th2 Cytokines, Upadacitinib Decreases Eotaxin-3 Secretion and Muscle Tension Gastroenterology (IF 29.4) Pub Date : 2024-02-14 Melissa Nelson, Xi Zhang, Eitan Podgaetz, Ava Melmed, Stuart J. Spechler, Rhonda F. Souza
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Reply to Silberg et al Gastroenterology (IF 29.4) Pub Date : 2024-02-14 Benjamin Lebwohl, Christopher Ma, Joseph A. Murray
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Endoscopic gallbladder stenting to prevent recurrent cholecystitis in deferred cholecystectomy: a randomized trial Gastroenterology (IF 29.4) Pub Date : 2024-02-14 Wiriyaporn Ridtitid, Julalak Karuehardsuwan, Natee Faknak, Panida Piyachaturawat, Phuphat Vongwattanakit, Santi Kulpatcharapong, Phonthep Angsuwatcharakon, Parit Mekaroonkamol, Pradermchai Kongkam, Rungsun Rerknimitr
Endoscopic transpapillary gallbladder stenting (ETGS) has been proposed as one of the adjunctive treatments, apart from antibiotics, before surgery in patients with acute cholecystitis whose cholecystectomy could not be performed or deferred. Currently, there are no comparative data on the outcomes of ETGS in those who receive and do not receive ETGS. We aimed to compare the rates of recurrent cholecystitis
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Abdominal pain and bilious vomiting with a dilated duodenum and stomach in a five-year-old boy Gastroenterology (IF 29.4) Pub Date : 2024-02-13 Rui Aoyagi, Masashi Ogasawara
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A look into the future: Are we ready for an approved therapy in celiac disease? Gastroenterology (IF 29.4) Pub Date : 2024-02-13 Robert P. Anderson, Ritu Verma, Michael Schumann
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Lifestyle-associated risk factor and gastrointestinal cancers: targeting potential of the gut microbe-host crosstalk-based metabolic processes Gastroenterology (IF 29.4) Pub Date : 2024-02-09 Ruize Qu, Zhipeng Zhang, Wei Fu
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Beyond time and space: charting dynamic evolution of sporadic colorectal cancer. Gastroenterology (IF 29.4) Pub Date : 2024-02-09 Pasquale Lombardi, David J. Pinato
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Colonoscopy vs. the Fecal Immunochemical Test: Which is Best? Gastroenterology (IF 29.4) Pub Date : 2024-02-09 Douglas J. Robertson, Douglas K. Rex, Oriana Ciani, Michael F. Drummond
While there is no debate around the effectiveness of colorectal cancer (CRC) screening in reducing disease burden, there remains a question regarding the most effective and cost-effective screening modality. Current United States guidelines present a panel of options that include the two most commonly used modalities, colonoscopy and stool testing with the fecal immunochemical test (FIT). Large-scale
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Survival of the fittest: Clonal selection of somatic mutations reveals targets to abate chronic liver injury Gastroenterology (IF 29.4) Pub Date : 2024-02-08 Natalie M. Niemi, Brian J. DeBosch
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Holding back the tide: Interferon-gamma to the rescue Gastroenterology (IF 29.4) Pub Date : 2024-02-08 Jay R. Thiagarajah
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A Rare Cause of Abdominal Pain and Weight Loss Gastroenterology (IF 29.4) Pub Date : 2024-02-07 Aashish Chalasani, Theresa Ly, Sudarshan Paramsothy
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A Rare Cause of Acute Liver Failure Gastroenterology (IF 29.4) Pub Date : 2024-02-06 Ying Gibbens, John Lake, Nicholas Lim
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Early initiation of biologics and disease outcomes in children and adults with inflammatory bowel diseases: results from the nationwide epi-IIRN cohort Gastroenterology (IF 29.4) Pub Date : 2024-02-06 Rona Lujan, Rachel Buchuk, Gili Focht, Dotan Yogev, Shira Greenfeld, Amir Ben-Tov, Yiska Loewenberg Weisband, Natan Lederman, Eran Matz, Shomron Ben Horin, Iris Dotan, Daniel Nevo, Dan Turner
In this nationwide study we explored whether early initiation of biologics is associated with improved outcomes in children and adults with Crohn’s disease (CD) and ulcerative colitis (UC). All patients diagnosed with CD or UC in Israel (2005-2020) were included in the epi-IIRN cohort, encompassing 98% of the population. We compared disease duration at biologics initiation (i.e., 0-3-months, >3-12-months
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Histologic Remission in Inflammatory Bowel Disease and Female Fertility: A Nationwide Study Gastroenterology (IF 29.4) Pub Date : 2024-02-06 Karl Mårild, Jonas Söderling, Olof Stephansson, Jordan Axelrad, Jonas Halfvarson, Gabriella Bröms, Jan Marsal, Ola Olén, Jonas F. Ludvigsson
Inflammatory bowel disease (IBD) is linked to reduced female fertility, but it is unclear how fertility rates vary by histological disease activity. Nationwide IBD cohort of Swedish women aged 15-44 years. We examined fertility rates during periods with vs. without histological inflammation (n=21,046; follow-up: 1990-2016) and during periods with vs. without clinical activity (IBD-related hospitalization
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A Novel Approach for Pancreas Transcriptomics Reveals the Cellular Landscape in Homeostasis and Acute Pancreatitis Gastroenterology (IF 29.4) Pub Date : 2024-02-06 Katherine J. Aney, Woo-Jeong Jeong, Andres F. Vallejo, Cassandra Burdziak, Ethan Chen, Austin Wang, Pal Koak, Kellie Wise, Kirk Jensen, Dana Pe’er, Stephanie K. Dougan, Luciano Martelotto, Sahar Nissim
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CHRONIC VISCERAL PAIN: NEW PERIPHERAL MECHANISTIC INSIGHTS AND RESULTING TREATMENTS Gastroenterology (IF 29.4) Pub Date : 2024-02-05 Alexander C. Ford, Stephen Vanner, Purna C. Kashyap, Yasmin Nasser
Chronic visceral pain is one of the most common reasons for patients with gastrointestinal disorders, such as inflammatory bowel disease or disorders of brain-gut interaction, to seek medical attention. It represents a substantial burden to patients, and is associated with anxiety, depression, reductions in quality of life, and impaired social functioning, as well as increased direct and indirect healthcare
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A Randomized Trial of Two Remote Healthcare Delivery Models on the Uptake of Genetic Testing and Impact on Patient-Reported Psychological Outcomes in Families With Pancreatic Cancer: The Genetic Education, Risk Assessment, and Testing (GENERATE) Study Gastroenterology (IF 29.4) Pub Date : 2024-02-05 Nicolette J. Rodriguez, C. Sloane Furniss, Matthew B. Yurgelun, Chinedu Ukaegbu, Pamela E. Constantinou, Ileana Fortes, Alyson Caruso, Alison N. Schwartz, Jill E. Stopfer, Meghan Underhill-Blazey, Barbara Kenner, Scott H. Nelson, Sydney Okumura, Alicia Y. Zhou, Tara B. Coffin, Hajime Uno, Miki Horiguchi, Allyson J. Ocean, Florencia McAllister, Andrew M. Lowy, Alison P. Klein, Lisa Madlensky, Gloria
Background and Aims Genetic testing uptake for cancer susceptibility in family members of cancer patients is suboptimal. Among relatives of pancreatic ductal adenocarcinoma (PDAC) patients, The GENetic Education, Risk Assessment, and TEsting (GENERATE) study evaluated two online genetic education/testing delivery models and their impact on patient-reported psychological outcomes (PRPOs). Methods Eligible
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Pembrolizumab-Induced Liver Injury: Beyond Immune-Mediated Hepatitis Gastroenterology (IF 29.4) Pub Date : 2024-02-05 Queralt Herms, Carla Fuster-Anglada, Adrià Juanola
Abstract not available
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Does a Rising Tide Lift All Boats? How Institutional Procedural Volume Impacts the Clinical Outcomes of Gastric Endoscopic Submucosal Dissection Gastroenterology (IF 29.4) Pub Date : 2024-02-03 Hiroyuki Aihara, Peter V. Draganov
Abstract not available
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Machine Learning–Based Prediction of Pediatric Ulcerative Colitis Treatment Response Using Diagnostic Histopathology Gastroenterology (IF 29.4) Pub Date : 2024-02-02 Xiaoxuan Liu, Surya Prasath, Iram Siddiqui, Thomas D. Walters, Lee A. Denson, Jasbir Dhaliwal, Jeffrey S. Hyams, Subra Kugathasan, Anne M. Griffiths, Margaret H. Collins, Robert N. Baldassano, Brendan M. Boyle, Melvin B. Heyman, Neal S. Leleiko, David Mack, James Markowitz, Joshua D. Noe, Maria Oliva-Hemker, Anthony Otley, Ashish S. Patel, Marian Pfefferkorn, Paul A. Rufo, Cary G. Sauer, Jennifer Strople
Abstract not available
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Has a Hundred Years of Pursuing Proteases Helped to Palliate Pain in Chronic Pancreatitis More Than Placebo? Gastroenterology (IF 29.4) Pub Date : 2024-02-02 Vijay P. Singh, Fred S. Gorelick
Abstract not available
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Recurrent Abdominal Pain Associated With Small Intestinal Edema Gastroenterology (IF 29.4) Pub Date : 2024-02-01 Qing Lu, Li Tang, Jinlin Yang
Abstract not available
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First Year on the Job as a Gastroenterologist and Hepatologist: Lessons Learned Gastroenterology (IF 29.4) Pub Date : 2024-02-01 Mohammad Bilal, Joshua M. Steinberg, Jeremy Louissaint, Jennifer Phan
Abstract not available
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Moving Away From Biopsy Confirmation of Celiac Disease Gastroenterology (IF 29.4) Pub Date : 2024-02-01 B, e, n, j, a, m, i, n, , L, e, b, w, o, h, l
Abstract not available
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Patient and Community Health Global Burden in a World with more Celiac Disease Gastroenterology (IF 29.4) Pub Date : 2024-02-01 Simona Gatti, Alberto Rubio-Tapia, Govind Makharia, Carlo Catassi
Celiac disease is one of the commonest life-long disorders worldwide, with a prevalence mostly ranging between 0.7 and 2.9 % in the general population and a higher frequency in females and in well-defined at-risk groups, such as relatives of affected individuals and patients with autoimmune co-morbidities. Increasing clinical detection is facilitated by improving awareness, implementation of a case-finding
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Patient-Reported Outcomes in Disorders of Gut–Brain Interaction Gastroenterology (IF 29.4) Pub Date : 2024-02-01 Jan Tack, Florencia Carbone, Lin Chang, Brian E. Lacy
Disorders of gut–brain interaction are characterized by chronic gastrointestinal symptoms in the absence of abnormal endoscopic or radiologic findings or objective biomarkers that can be identified during routine clinical evaluation. The assessment of the symptom pattern and severity, therefore, is the key modality to evaluate the presence, impact, and evolution of these conditions, for both clinical
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Opportunities for Improving Biopsy and Non-Biopsy-Based Diagnosis of Celiac Disease Gastroenterology (IF 29.4) Pub Date : 2024-01-30 Marie E. Robert, Carolina Ciacci, Benjamin Lebwohl
The accumulating data regarding a non-biopsy diagnosis of celiac disease has led to its adoption in certain scenarios, though debate on whether and when to use non-biopsy criteria in clinical practice remains ongoing. Despite the growing popularity and evidence basis for a biopsy-free approach to diagnosis in the context of highly elevated serologies, there will nevertheless continue to be a role for
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VEDOLIZUMAB DOES NOT ALTER IMMUNOGLOBULIN LEVELS IN BREASTMILK OF MOTHERS WITH IBD Gastroenterology (IF 29.4) Pub Date : 2024-01-25 Josef Urrete, Taniya Mitra, Kerri Bertrand, Christina Chambers, Jesus Rivera-Nieves
Abstract not available