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Signal Transduction and Targeted Therapy
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SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-30 Xinling Wang, Lu Lu, Shibo Jiang
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Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-29 Daoyuan Xie, Yaomei Tian, Die Hu, Yuanda Wang, Yuling Yang, Bailing Zhou, Rui Zhang, Zhixiang Ren, Mohan Liu, Jie Xu, Chunyan Dong, Binyan Zhao, Li Yang
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Signaling pathways and targeted therapies for psoriasis Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-27 Jia Guo, Hanyi Zhang, Wenri Lin, Lixia Lu, Juan Su, Xiang Chen
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Multifunctional mesoporous silica nanoparticles for biomedical applications Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-24 Bolong Xu, Shanshan Li, Rui Shi, Huiyu Liu
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γδ T cells: origin and fate, subsets, diseases and immunotherapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-22 Yi Hu, Qinglin Hu, Yongsheng Li, Ligong Lu, Zheng Xiang, Zhinan Yin, Dieter Kabelitz, Yangzhe Wu
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Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-20 Chi Wang Ip, Jörg Wischhusen
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Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-20 Yongchao Zhao, Weidong Xiong, Chaofu Li, Ranzun Zhao, Hao Lu, Shuai Song, You Zhou, Yiqing Hu, Bei Shi, Junbo Ge
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The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-18 Dieter Kabelitz
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Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-17 Yiqun Han, Jiayu Wang, Tao Sun, Quchang Ouyang, Jianwen Li, Jie Yuan, Binghe Xu
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Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-15 Hange Yang, Xiaowei Zhang, Cong Wang, Hailong Zhang, Juan Yi, Kun Wang, Yanzhe Hou, Peihong Ji, Xiaojie Jin, Chenghao Li, Min Zhang, Shan Huang, Haoyuan Jia, Kuan Hu, Lingyun Mou, Rui Wang
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Decoding γδ T cell anticancer therapies: integrating CRISPR screens with tumor organoids Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-13 Jian Zhou, Min Wu, Gen Yang
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Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-13 Priyanka Dey Talukdar, Urmi Chatterji
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Single-cell genomics: the human biomolecular and cell atlases Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-10 Yuqing Mei, Jingjing Wang, Guoji Guo
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Nuclear transport proteins: structure, function, and disease relevance Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-10 Yang Yang, Lu Guo, Lin Chen, Bo Gong, Da Jia, Qingxiang Sun
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Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-10 Lin Wang, Jia-Bao Cao, Bin-Bin Xia, Yue-Juan Li, Xuan Zhang, Guo-Xin Mo, Rui-Juan Wang, Si-Qi Guo, Yu-Qing Zhang, Kun Xiao, Guang-Fa Zhu, Peng-Fei Liu, Li-Cheng Song, Xi-Hui Ma, Ping-Chao Xiang, Jiang Wang, Yu-Hong Liu, Fei Xie, Xu-Dong Zhang, Xiang-Xin Li, Wan-Lu Sun, Yan Cao, Kai-Fei Wang, Wen-Hui Zhang, Wei-Chao Zhao, Peng Yan, Ji-Chao Chen, Yu-Wei Yang, Zhong-Kuo Yu, Jing-Si Tang, Li Xiao, Jie-Min
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Sellhi neutrophils: a key to triumph in cancer therapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-08 Ekaterina Pylaeva, Jadwiga Jablonska
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The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-08 Jiaorong Qu, Bojun Qiu, Yuxin Zhang, Yan Hu, Zhixing Wang, Zhiang Guan, Yiming Qin, Tongtong Sui, Fan Wu, Boyang Li, Wei Han, Xiaozhong Peng
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Human embryo models: unveiling sophisticated self-organization of stem cells during post-implantation stages Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-06 Manqiang Lin, Michael Sigal
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Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-06 Zhi-Qiang Wang, Zhao-Cong Zhang, Yu-Yang Wu, Ya-Nan Pi, Sheng-Han Lou, Tian-Bo Liu, Ge Lou, Chang Yang
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SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-04 Xiayao Diao, Chao Guo, Hanhao Zheng, Ke Zhao, Yuming Luo, Mingjie An, Yan Lin, Jiancheng Chen, Yuanlong Li, Yuting Li, Xuehan Gao, Jiaqi Zhang, Mengxin Zhou, Wenliang Bai, Lei Liu, Guige Wang, Lanjun Zhang, Xiaotian He, Rusi Zhang, Zhihua Li, Changhao Chen, Shanqing Li
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Smart nanoparticles for cancer therapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-03 Leming Sun, Hongmei Liu, Yanqi Ye, Yang Lei, Rehmat Islam, Sumin Tan, Rongsheng Tong, Yang-Bao Miao, Lulu Cai
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The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-01 Jingwei Li, Yun Zhou, Jiechao Ma, Qin Zhang, Jun Shao, Shufan Liang, Yizhou Yu, Weimin Li, Chengdi Wang
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Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-11-01 Liangjiang Huang, Song Zhang, Jun Wu, Baojie Guo, Tingting Gao, Sayed Zulfiqar Ali Shah, Bo Huang, Yajie Li, Bo Zhu, Jiaqi Fan, Liu Wang, Yani Xiao, Wenjing Liu, Yao Tian, Zhengyu Fang, Yingying Lv, Lingfeng Xie, Sheng Yao, Gaotan Ke, Xiaolin Huang, Ying Huang, Yujuan Li, Yi Jia, Zhongwen Li, Guihai Feng, Yan Huo, Wei Li, Qi Zhou, Jie Hao, Baoyang Hu, Hong Chen
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Dietary reprogram of macrophages for cell competition: a promising strategy for malignant cancer control Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-27 Jian Chen, Zhaoliang Su, Guangchuan Wang
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Unmasking metabolic dependencies in pancreatic cancer: aberrant polyamine synthesis as a promising new therapeutic target Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-27 Gerrit Wolters-Eisfeld, Thilo Hackert, Cenap Güngör
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Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase II study Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-27 Tian-Qi Zhang, Zhi-Jun Geng, Meng-Xuan Zuo, Ji-Bin Li, Jin-Hua Huang, Zi-Lin Huang, Pei-Hong Wu, Yang-Kui Gu
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RNA modification in cardiovascular disease: implications for therapeutic interventions Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-27 Cong Wang, Xuyang Hou, Qing Guan, Huiling Zhou, Li Zhou, Lijun Liu, Jijia Liu, Feng Li, Wei Li, Haidan Liu
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Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-25 Nana Bie, Tuying Yong, Zhaohan Wei, Qingle Liang, Xiaoqiong Zhang, Shiyu Li, Xin Li, Jianye Li, Lu Gan, Xiangliang Yang
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Characteristics of premanufacture CD8+T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-25 Yao Wang, Chuan Tong, Yuting Lu, Zhiqiang Wu, Yelei Guo, Yang Liu, Jianshu Wei, Chunmeng Wang, Qingming Yang, Weidong Han
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Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/ CDKN2A Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-25 Javier Martin-Broto, Jeronimo Martinez-Garcia, David S. Moura, Andres Redondo, Antonio Gutierrez, Antonio Lopez-Pousa, Javier Martinez-Trufero, Isabel Sevilla, Roberto Diaz-Beveridge, Maria Pilar Solis-Hernandez, Amancio Carnero, Marco Perez, David Marcilla, Jesus Garcia-Foncillas, Pablo Romero, Javier Fernandez-Jara, Daniel Lopez-Lopez, Ivan Arribas, Nadia Hindi
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Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-24 Hao-Yun Peng, Liqing Wang, Jugal Kishore Das, Anil Kumar, Darby J. Ballard, Yijie Ren, Xiaofang Xiong, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song
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Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19 Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-23 Xiaosong Li, Pai Peng, Haijun Deng, Qian Yang, Shi Chen, Benhua Li, Miao He, Aishun Jin, Zhu Yang, Ni Tang, Ailong Huang
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Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer’s disease Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-23 Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min Li
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From signalling pathways to targeted therapies: unravelling glioblastoma’s secrets and harnessing two decades of progress Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-20 Brittany Dewdney, Misty R. Jenkins, Sarah A. Best, Saskia Freytag, Krishneel Prasad, Jeff Holst, Raelene Endersby, Terrance G. Johns
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Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456 Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-19 Jingjing Wan, Zhen Zhang, Chennan Wu, Saisai Tian, Yibei Zang, Ge Jin, Qingyan Sun, Pin Wang, Xin Luan, Yili Yang, Xuelin Zhan, Lingyu Linda Ye, Dayue Darrel Duan, Xia Liu, Weidong Zhang
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B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-20 Xinyu Tian, Xiangyun Zheng, Dong Tian
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Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-20 Yue Wang, Jingyi Han, Dongdong Wang, Menghua Cai, Yi Xu, Yu Hu, Hui Chen, Wei He, Jianmin Zhang
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Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-18 Ming Cui, Ya Hu, Zejian Zhang, Tianqi Chen, Menghua Dai, Qiang Xu, Junchao Guo, Taiping Zhang, Quan Liao, Jun Yu, Yupei Zhao
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Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-18 Yi Wang, Laurence Don Wai Luu, Shuang Liu, Xiong Zhu, Siyuan Huang, Fang Li, Xiaolan Huang, Linying Guo, Jin Zhang, Haiyan Ge, Yuanyuan Sun, Yi Hui, Yanning Qu, Huicong Wang, Xiaoxia Wang, Weilan Na, Juan Zhou, Dong Qu, Jun Tai
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Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-18 Bingyu Li, Ping Jing, Genhui Zheng, Chenyu Pi, Lu Zhang, Zuojing Yin, Lijun Xu, Jingxuan Qiu, Hua Gu, Tianyi Qiu, Jianmin Fang
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Cephalopod RNA recoding: linking protein plasticity to thermal adaptation and catalyzing beyond-species protein characterization Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-16 Junyi Wang, Guoping Li, Min Wu
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Activated STING: an ion channel to trigger non-interferon-related functions Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-16 Zhengyu Gao, Bin Wang, Long Zhang
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Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-16 Catarina Macedo-Silva, Vera Miranda-Gonçalves, Nuno Tiago Tavares, Daniela Barros-Silva, Joana Lencart, João Lobo, Ângelo Oliveira, Margareta P. Correia, Lucia Altucci, Carmen Jerónimo
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Safety and clinical efficacy of sintilimab (anti-PD-1) in pediatric patients with advanced or recurrent malignancies in a phase I study Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-13 Yi Que, Juan Wang, Feifei Sun, Shan Wang, Jia Zhu, Junting Huang, Zhenzhen Zhao, Li Zhang, Juan Liu, Jiaqian Xu, Zijun Zhen, Xiaofei Sun, Suying Lu, Yizhuo Zhang
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Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-13 Yan Liu, Yi-hui Shao, Jun-meng Zhang, Ying Wang, Mei Zhou, Hui-qin Li, Cong-cong Zhang, Pei-jie Yu, Shi-juan Gao, Xue-rui Wang, Li-xin Jia, Chun-mei Piao, Jie Du, Yu-lin Li
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Astrocytes in human central nervous system diseases: a frontier for new therapies Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-13 Alexei Verkhratsky, Arthur Butt, Baoman Li, Peter Illes, Robert Zorec, Alexey Semyanov, Yong Tang, Michael V. Sofroniew
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The IL-17 family in diseases: from bench to bedside Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-11 Longjie Huangfu, Ruiying Li, Yamei Huang, Shan Wang
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Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-11 Pietro Di Fazio
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Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-11 Xia Xu, Tao Yu, Lingling Dong, Rainer Glauben, Siyuan Wu, Ronghua Huang, Shiwei Qumu, Chenli Chang, Jing Guo, Lin Pan, Ting Yang, Xin Lin, Ke Huang, Zhihua Chen, Chen Wang
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P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-09 Ming Liu, Bingtai Lu, Yue Li, Shuofeng Yuan, Zhen Zhuang, Guangyu Li, Dong Wang, Liuheyi Ma, Jianheng Zhu, Jinglu Zhao, Chris Chung-Sing Chan, Vincent Kwok-Man Poon, Kenn Ka-Heng Chik, Zhiyao Zhao, Huifang Xian, Jingxian Zhao, Jincun Zhao, Jasper Fuk-Woo Chan, Yuxia Zhang
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Drug-microbiota interactions: an emerging priority for precision medicine Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-09 Qing Zhao, Yao Chen, Weihua Huang, Honghao Zhou, Wei Zhang
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Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-09 Janusz von Renesse, Peter Mirtschink
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Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-09 Désirée Gül, Oliver H. Krämer, Christoph Reinhardt
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SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-06 Rongzhang He, Xingyu Zheng, Jian Zhang, Bo Liu, Qijie Wang, Qian Wu, Ziyan Liu, Fangfang Chang, Yabin Hu, Ting Xie, Yongchen Liu, Jun Chen, Jing Yang, Shishan Teng, Rui Lu, Dong Pan, You Wang, Liting Peng, Weijin Huang, Velislava Terzieva, Wenpei Liu, Youchun Wang, Yi-Ping Li, Xiaowang Qu
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Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-06 Yuan Gao, Liqing Yu, Hongming Miao
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Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-06 Ying Fang, Mu-Chen Zhang, Yang He, Chen Li, Hai Fang, Peng-Peng Xu, Shu Cheng, Yan Zhao, Yan Feng, Qian Liu, Li Wang, Wei-Li Zhao
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Safeguarding transcriptional memory: a mitotic bookmarking role for chromatin remodelers Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-04 Godwin Sokpor, Huu Phuc Nguyen, Tran Tuoc
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Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-04 Ruben A. Ferrer, Marta Torregrossa, Sandra Franz
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Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-04 Yijing Lu, Wenlong Yang, Zhiyong Qi, Rifeng Gao, Jing Tong, Tingwen Gao, Yin Zhang, Aijun Sun, Shuning Zhang, Junbo Ge
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Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition Signal Transduct. Target Ther. (IF 39.3) Pub Date : 2023-10-02 Sijia Liu, Jiang Ren, Long Zhang
更新日期：2023-11-29
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