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C3G contributes to platelet activation and aggregation by regulating major signaling pathways Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-04-01 Sara Gutiérrez-Herrero; Cristina Fernández-Infante; Luis Hernández-Cano; Sara Ortiz-Rivero; Carlos Guijas; Víctor Martín-Granado; José Ramón González-Porras; Jesús Balsinde; Almudena Porras; Carmen Guerrero
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NLRP3 inflammasome as a novel therapeutic target for Alzheimer’s disease Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-04-01 Yun Zhang; Zhifang Dong; Weihong Song
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Inhibition of USP14 and UCH37 deubiquitinating activity by b-AP15 as a potential therapy for tumors with p53 deficiency Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-04-01 Yu-Shui Ma; Xiao-Feng Wang; Fei Yu; Ting-Miao Wu; Ji-Bin Liu; Yun-Jie Zhang; Qing Xia; Zong-Yuan Jiang; Qin-Lu Lin; Da Fu
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Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-27 Li Tan; Qi Wang; Duanyang Zhang; Jinya Ding; Qianchuan Huang; Yi-Quan Tang; Qiongshu Wang; Hongming Miao
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The circFASN/miR-33a pathway participates in tacrolimus-induced dysregulation of hepatic triglyceride homeostasis Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-27 Chenzhi Zhang; Kangchen Chen; Rongli Wei; Guanghan Fan; Xuechun Cai; Li Xu; Beini Cen; Jianguo Wang; Haiyang Xie; Shusen Zheng; Xiao Xu
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The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-27 Dapeng Zhang; Rongchen Shi; Wei Xiang; Xia Kang; Bo Tang; Chuan Li; Linfeng Gao; Xuan Zhang; Lili Zhang; Rongyang Dai; Hongming Miao
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Comprehensive review of targeted therapy for colorectal cancer Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-20 Yuan-Hong Xie; Ying-Xuan Chen; Jing-Yuan Fang
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Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD + acute myeloid leukemia Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-13 Dan Li; Tongjuan Li; Zhen Shang; Lei Zhao; Qian Xu; Jiaqi Tan; Yun Qin; Yuanyuan Zhang; Yang Cao; Na Wang; Liang Huang; Xiaojian Zhu; Kuangguo Zhou; Liting Chen; Chunrui Li; Ting Xie; Yi Yang; Jue Wang; Jianfeng Zhou
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Molecular principles of metastasis: a hallmark of cancer revisited Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-12 Jawad Fares; Mohamad Y. Fares; Hussein H. Khachfe; Hamza A. Salhab; Youssef Fares
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CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-11 Zhen Zhang; Jianjun Li; Yang Ou; Guang Yang; Kaiyuan Deng; Qiong Wang; Zhaoyang Wang; Wenhao Wang; Quansheng Zhang; Hang Wang; Wei Sun; Peiqing Sun; Shuang Yang
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Advances in targeted therapy for malignant lymphoma Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-06 Li Wang; Wei Qin; Yu-Jia Huo; Xiao Li; Qing Shi; John E. J. Rasko; Anne Janin; Wei-Li Zhao
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The identification of a CD47-blocking “hotspot” and design of a CD47/PD-L1 dual-specific antibody with limited hemagglutination Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-06 Rui Shi; Yan Chai; Xiaomin Duan; Xiaoshan Bi; Qingrui Huang; Qihui Wang; Shuguang Tan; George F. Gao; Jianhua Zhu; Jinghua Yan
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Cancer-associated histone mutation H2BG53D disrupts DNA–histone octamer interaction and promotes oncogenic phenotypes Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-06 Yi Ching Esther Wan; Tsz Chui Sophia Leung; Dongbo Ding; Xulun Sun; Jiaxian Liu; Lina Zhu; Tze Zhen Evangeline Kang; Du Yang; Yuchen Zhang; Jitian Zhang; Chengmin Qian; Michael Shing Yan Huen; Qing Li; Maggie Zi Ying Chow; Zongli Zheng; Junhong Han; Ajay Goel; Xin Wang; Toyotaka Ishibashi; Kui Ming Chan
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D609 protects retinal pigmented epithelium as a potential therapy for age-related macular degeneration Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-04 Bowen Wang; Li Wang; Sijie Gu; Yankun Yu; Huaxing Huang; Kunlun Mo; He Xu; Fanzhu Zeng; Yichen Xiao; Lulu Peng; Chunqiao Liu; Nan Cao; Yizhi Liu; Jin Yuan; Hong Ouyang
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Mitochondrial dysfunction and alcohol-associated liver disease: a novel pathway and therapeutic target Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-03-03 Mohamed A. Abdallah; Ashwani K. Singal
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The role of ubiquitination in tumorigenesis and targeted drug discovery Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-29 Lu Deng; Tong Meng; Lei Chen; Wenyi Wei; Ping Wang
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SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-28 Xavier Palomer; M. Silvia Román-Azcona; Javier Pizarro-Delgado; Ana Planavila; Francesc Villarroya; Brenda Valenzuela-Alcaraz; Fátima Crispi; Álvaro Sepúlveda-Martínez; Irene Miguel-Escalada; Jorge Ferrer; J. Francisco Nistal; Raquel García; Mercy M. Davidson; Emma Barroso; Manuel Vázquez-Carrera
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Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-26 Daniel A. Luedtke; Yongwei Su; Jun Ma; Xinyu Li; Steven A. Buck; Holly Edwards; Lisa Polin; Juiwanna Kushner; Sijana H. Dzinic; Kathryn White; Hai Lin; Jeffrey W. Taub; Yubin Ge
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Switching off DNA repair—how colorectal cancer evades targeted therapies through adaptive mutability Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-21 Jörg Fahrer
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Potential benefits of precise corticosteroids therapy for severe 2019-nCoV pneumonia Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-21 Wei Zhou; Yisi Liu; Dongdong Tian; Cheng Wang; Sa Wang; Jing Cheng; Ming Hu; Minghao Fang; Yue Gao
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Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn–AhR–AQP4 signaling pathway Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-21 Lisha Du; Zikang Xing; Bangbao Tao; Tianqi Li; Dan Yang; Weirui Li; Yuanting Zheng; Chunxiang Kuang; Qing Yang
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Potential targeted therapy and diagnosis based on novel insight into growth factors, receptors, and downstream effectors in acute kidney injury and acute kidney injury-chronic kidney disease progression. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-14 Li Gao,Xiang Zhong,Juan Jin,Jun Li,Xiao-Ming Meng
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Silencing MYH9 blocks HBx-induced GSK3β ubiquitination and degradation to inhibit tumor stemness in hepatocellular carcinoma. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-14 Xian Lin,Ai-Min Li,Yong-Hao Li,Rong-Cheng Luo,Yu-Jiao Zou,Yi-Yi Liu,Chen Liu,Ying-Ying Xie,Shi Zuo,Zhan Liu,Zhen Liu,Wei-Yi Fang
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Targeting cancer stem cell pathways for cancer therapy. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-07 Liqun Yang,Pengfei Shi,Gaichao Zhao,Jie Xu,Wen Peng,Jiayi Zhang,Guanghui Zhang,Xiaowen Wang,Zhen Dong,Fei Chen,Hongjuan Cui
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Fibronectin-targeted dual-acting micelles for combination therapy of metastatic breast cancer. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-02-07 Zhuoran Gong,Min Chen,Qiushi Ren,Xiuli Yue,Zhifei Dai
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PIM kinase inhibition: co-targeted therapeutic approaches in prostate cancer. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-01-31 Sabina Luszczak,Christopher Kumar,Vignesh Krishna Sathyadevan,Benjamin S Simpson,Kathy A Gately,Hayley C Whitaker,Susan Heavey
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NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-01-24 Bruna Alves Fenerich,Jaqueline Cristina Fernandes,Ana Paula Nunes Rodrigues Alves,Juan Luiz Coelho-Silva,Renata Scopim-Ribeiro,Priscila Santos Scheucher,Christopher A Eide,Cristina E Tognon,Brian J Druker,Eduardo Magalhães Rego,João Agostinho Machado-Neto,Fabiola Traina
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Targeting folate receptor β positive tumor-associated macrophages in lung cancer with a folate-modified liposomal complex. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-01-22 Yan Tie,Heng Zheng,Zhiyao He,Jingyun Yang,Bin Shao,Li Liu,Min Luo,Xia Yuan,Yu Liu,Xiangxian Zhang,Hongyi Li,Min Wu,Xiawei Wei
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Role of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-01-17 Huan-Xin Chen,Ming-Yang Li,Yi-Yao Jiang,Hai-Tao Hou,Jun Wang,Xiao-Cheng Liu,Qin Yang,Guo-Wei He
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DNA methylation markers in the diagnosis and prognosis of common leukemias. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-01-10 Hua Jiang,Zhiying Ou,Yingyi He,Meixing Yu,Shaoqing Wu,Gen Li,Jie Zhu,Ru Zhang,Jiayi Wang,Lianghong Zheng,Xiaohong Zhang,Wenge Hao,Liya He,Xiaoqiong Gu,Qingli Quan,Edward Zhang,Huiyan Luo,Wei Wei,Zhihuan Li,Guangxi Zang,Charlotte Zhang,Tina Poon,Daniel Zhang,Ian Ziyar,Run-Ze Zhang,Oulan Li,Linhai Cheng,Taylor Shimizu,Xinping Cui,Jian-Kang Zhu,Xin Sun,Kang Zhang
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Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-01-03 Hongyi Li,Yang Yang,Weiqi Hong,Mengyuan Huang,Min Wu,Xia Zhao
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Use of a 6-miRNA panel to distinguish lymphoma from reactive lymphoid hyperplasia. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2020-01-03 Juanjuan Kang,Sisi Yu,Song Lu,Guohui Xu,Jiang Zhu,Na Yan,Delun Luo,Kai Xu,Zhihui Zhang,Jian Huang
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PROTACs: great opportunities for academia and industry. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-24 Xiuyun Sun,Hongying Gao,Yiqing Yang,Ming He,Yue Wu,Yugang Song,Yan Tong,Yu Rao
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The β-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-24 Tianyi Liu,Linli Zhou,Kun Yang,Kentaro Iwasawa,Ana Luisa Kadekaro,Takanori Takebe,Thomas Andl,Yuhang Zhang
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The emerging treatment landscape of targeted therapy in non-small-cell lung cancer. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-17 Min Yuan,Li-Li Huang,Jian-Hua Chen,Jie Wu,Qing Xu
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Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-17 Yuan Cheng,Cai He,Manni Wang,Xuelei Ma,Fei Mo,Shengyong Yang,Junhong Han,Xiawei Wei
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TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-13 Renle Du,Wenzhi Shen,Yi Liu,Wenjuan Gao,Wei Zhou,Jun Li,Shuangtao Zhao,Chong Chen,Yanan Chen,Yanhua Liu,Peiqing Sun,Rong Xiang,Yi Shi,Yunping Luo
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Integrative analysis of DNA methylation and gene expression identified cervical cancer-specific diagnostic biomarkers. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-13 Wanxue Xu,Mengyao Xu,Longlong Wang,Wei Zhou,Rong Xiang,Yi Shi,Yunshan Zhang,Yongjun Piao
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Structures of BRAF-MEK1-14-3-3 sheds light on drug discovery. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-13 Qiu Sun,Wenjing Wang
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Peptides encoded by noncoding genes: challenges and perspectives. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-13 Shuo Wang,Chuanbin Mao,Shanrong Liu
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MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer's disease models. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-06 Yehong Du,Yexiang Du,Yun Zhang,Zhilin Huang,Min Fu,Junjie Li,Yayan Pang,Peng Lei,Yu Tian Wang,Weihong Song,Guiqiong He,Zhifang Dong
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DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-06 Hao Zhou,Pingjun Zhu,Jin Wang,Sam Toan,Jun Ren
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Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-12-06 Rui Zhang,Hao-Ming Lin,Ruth Broering,Xiang-de Shi,Xian-Huan Yu,Lei-Bo Xu,Wen-Rui Wu,Chao Liu
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Dual inhibition of CDK4 and FYN leads to selective cell death in KRAS-mutant colorectal cancer. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-11-29 Yan Wang,Rongjie Lin,Huan Ling,Yuan Ke,Yangyang Zeng,Yudi Xiong,Qian Zhou,Fuxiang Zhou,Yunfeng Zhou
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Tumor-suppressive function and mechanism of HOXB13 in right-sided colon cancer. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-11-29 Binbin Xie,Bingjun Bai,Yuzi Xu,Yunlong Liu,Yiming Lv,Xing Gao,Fei Wu,Zhipeng Fang,Ying Lou,Hongming Pan,Weidong Han
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PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-11-29 Shuiping Liu,Haoming Lin,Da Wang,Qiang Li,Hong Luo,Guoxiong Li,Xiaohui Chen,Yongqiang Li,Peng Chen,Bingtao Zhai,Wengang Wang,Ruonan Zhang,Bi Chen,Mingming Zhang,Xuemeng Han,Qiujie Li,Liuxi Chen,Ying Liu,Xiaying Chen,Guohua Li,Yu Xiang,Ting Duan,Jiao Feng,Jianshu Lou,Xingxing Huang,Qin Zhang,Ting Pan,Lili Yan,Ting Jin,Wenzheng Zhang,Lvjia Zhuo,Yitian Sun,Tian Xie,Xinbing Sui
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Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence. Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-11-29 Yingxi Li,Xiyang Li,Mei Cao,Yuke Jiang,Jie Yan,Ze Liu,Rongcun Yang,Xu Chen,Peiqing Sun,Rong Xiang,Longlong Wang,Yi Shi
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Unbiased screening reveals that blocking exportin 1 overcomes resistance to PI3Kα inhibition in breast cancer Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-11-22 Xue-Ling Liu, Bo-Bo Wang, Yi Wang, Yu-Xiang Wang, Chun-hao Yang, Cun Tan, Xi Zhang, Qiao-jun He, Jian Ding, Ling-Hua Meng
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Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9 Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-11-18 YongHao Li, Xiong Liu, Xian Lin, Menyang Zhao, Yanyi Xiao, Chen Liu, Zixi Liang, Zelong Lin, Renhui Yi, Zibo Tang, Jiahao Liu, Xin Li, Qingping Jiang, Libo Li, Yinyin Xie, Zhen Liu, Weiyi Fang
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Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-07-26 Heng Zheng, Yan Tie, Zhen Fang, Xiaoai Wu, Tao Yi, Shuang Huang, Xiao Liang, Yanping Qian, Xi Wang, Ruyu Pi, Siyuan Chen, Yong Peng, Shengyong Yang, Xia Zhao, Xiawei Wei
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The proatherosclerotic function of indoleamine 2, 3-dioxygenase 1 in the developmental stage of atherosclerosis Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-07-19 Heng Liang, Mantian Chen, Fangfei Qi, Lei Shi, Zhenzhen Duan, Ruoyu Yang, Jinchao He, Bin Lou, Yigang Li, Qing Yang
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EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-07-12 Lixian Yang, Shilong Ying, Shiman Hu, Xiangtong Zhao, Muchun Li, Miaoqin Chen, Yiran Zhu, Ping Song, Liyuan Zhu, Tingting Jiang, Huimin An, Neelum Aziz Yousafzai, Wenxia Xu, Zhiguo Zhang, Xian Wang, Lifeng Feng, Hongchuan Jin
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Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-07-05 Zhiquan Song, Ying Xie, Zongpei Guo, Yang Han, Hua Guan, Xiaodan Liu, Teng Ma, Ping-kun Zhou
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ReishiMax inhibits mTORC1/2 by activating AMPK and inhibiting IGFR/PI3K/Rheb in tumor cells Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-06-28 Didem Sohretoglu, Chao Zhang, Jun Luo, Shile Huang
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Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-06-19 Ina Nepstad, Kimberley Joanne Hatfield, Ida Sofie Grønningsæter, Elise Aasebø, Maria Hernandez-Valladares, Karen Marie Hagen, Kristin Paulsen Rye, Frode S. Berven, Frode Selheim, Håkon Reikvam, Øystein Bruserud
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Therapeutic effects of a novel BAFF blocker on arthritis Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-06-14 Bailing Zhou, Hailong Zhang, Xiaoqing Su, Yi Luo, Xiaopeng Li, Chaoheng Yu, Qibing Xie, Xuyang Xia, Gu He, Li Yang
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PD-L1 in the palm of your hand: palmitoylation as a target for immuno-oncology Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-06-07 Andreas von Knethen, Bernhard Brüne
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Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-05-24 Qiu Sun, Yuehong Hu, Yijun Gu, Jiangkun Huang, Jun He, Lan Luo, Yi Yang, Shuo Yin, Chao Dou, Tianqi Wang, Xianghui Fu, Ling He, Shiqian Qi, Xiaofeng Zhu, Shengyong Yang, Xiawei Wei, Wei Cheng
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Pazopanib in advanced soft tissue sarcomas Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-05-17 Alex T. J. Lee, Robin L. Jones, Paul H. Huang
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Serotonylation: A novel histone H3 marker Signal Transduct. Target Ther. (IF 5.873) Pub Date : 2019-05-10 Lin Fu, Lingqiang Zhang
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