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Signal Transduction and Targeted Therapy
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ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-15 Xiao-Hui Ma, Jiang-Han-Zi Liu, Chun-Yu Liu, Wan-Yang Sun, Wen-Jun Duan, Guan Wang, Hiroshi Kurihara, Rong-Rong He, Yi-Fang Li, Yang Chen, Hongcai Shang
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Gut microbes regulate the feeding center: a new discovery of Gut Brain Axis Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-13 Fengwu Chen, Kaijian Hou, Zhe-Sheng Chen
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Cross-neutralization and cross-protection among SARS-CoV-2 viruses bearing different variant spikes Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-13 Yang Liu, Jianying Liu, Jing Zou, Birte Kalveram, Rafael R. G. Machado, Ping Ren, Sina Türeli, Derek J. Smith, Scott C. Weaver, Xuping Xie, Pei-Yong Shi
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Regulated cell death (RCD) in cancer: key pathways and targeted therapies Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-13 Fu Peng, Minru Liao, Rui Qin, Shiou Zhu, Cheng Peng, Leilei Fu, Yi Chen, Bo Han
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Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-13 Xiaohan Xu, Kyle L. Poulsen, Lijuan Wu, Shan Liu, Tatsunori Miyata, Qiaoling Song, Qingda Wei, Chenyang Zhao, Chunhua Lin, Jinbo Yang
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Dynamic mechanism of GPCR-mediated β-arrestin: a potential therapeutic agent discovery of biased drug Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-12 Zheng Xu, Zhenhua Shao
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Engineered virus-like particles: paving the way for effective somatic genome editing Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-12 Chenya Zhuo, Yu Tao, Mingqiang Li
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Time’s up: mutation rate and lifespan Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-12 Anjali Cremer, Wesley T. Abplanalp, Michael A. Rieger
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Mitochondrial pyruvate carrier: a metabolic-epigenetic checkpoint orchestrating T cell differentiation Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-12 Yu Chen, Jingchun Wang, Yongsheng Li
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Enhancer-promoter communication: unraveling enhancer strength and positioning within a given topologically associating domain (TAD) Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-12 Benedetto Daniele Giaimo, Tilman Borggrefe
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A dual-specific CRISPR-Cas nanosystem for precision therapeutic editing of liver disorders Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-12 Xiaojie Xu, Honglin Tang, Jiajing Guo, Huhu Xin, Yuan Ping
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Multi-omics characterization and therapeutic liability of ferroptosis in melanoma Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-10 Yi He, Yu Dong, Yong Chen, Guanxiong Zhang, Hailun Zhang, Guang Lei, Yanhua Du, Xiang Chen, Youqiong Ye, Hong Liu
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Curse and blessing: upregulation of oncogenes upon treatment with hypomethylating agents in myelodysplastic syndrome Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-09 Juliane Grimm, Mascha Binder
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Targeting folliculin to selectively inhibit mTORC1: a promising strategy for treating nonalcoholic fatty liver disease Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-09 Yan Ling, Yanpeng Li, Liang Li
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A cis-eQTL in NSUN2 promotes esophageal squamous-cell carcinoma progression and radiochemotherapy resistance by mRNA-m5C methylation Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-08 Xiangjie Niu, Linna Peng, Weiling Liu, Chuanwang Miao, Xinjie Chen, Jiahui Chu, Xinyu Yang, Wen Tan, Chen Wu, Dongxin Lin
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Stem cell-based therapy for human diseases Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-06 Duc M. Hoang, Phuong T. Pham, Trung Q. Bach, Anh T. L. Ngo, Quyen T. Nguyen, Trang T. K. Phan, Giang H. Nguyen, Phuong T. T. Le, Van T. Hoang, Nicholas R. Forsyth, Michael Heke, Liem Thanh Nguyen
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Human umbilical cord mesenchymal stem cells for psoriasis: a phase 1/2a, single-arm study Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-05 Lamei Cheng, Siqi Wang, Cong Peng, Xiao Zou, Chao Yang, Hua Mei, Chuang Li, Xian Su, Na Xiao, Qi Ouyang, Mi Zhang, Qiaolin Wang, Yan Luo, Minxue Shen, Qun Qin, Honglin Wang, Wu Zhu, Guangxiu Lu, Ge Lin, Yehong Kuang, Xiang Chen
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Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-04 Honghai Tang, Daqi Wang, Yilai Shu
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Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-03 Fubing Li, Huichun Liang, Hua You, Ji Xiao, Houjun Xia, Xi Chen, Maobo Huang, Zhuo Cheng, Chuanyu Yang, Wenjing Liu, Hailin Zhang, Li Zeng, Yingying Wu, Fei Ge, Zhen Li, Wenhui Zhou, Yi Wen, Zhongmei Zhou, Rong Liu, Dewei Jiang, Ni Xie, Bin Liang, Zhenzhen Liu, Yanjie Kong, Ceshi Chen
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Peptidic defective interfering gene nanoparticles against Omicron, Delta SARS-CoV-2 variants and influenza A virus in vivo Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-03 Hanjun Zhao, Chuyuan Zhang, Hoiyan Lam, Xinjie Meng, Zheng Peng, Man Lung Yeung, Jasper Fuk-Woo Chan, Kelvin Kai-Wang To, Kwok-Yung Yuen
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Ketogenic diet: new avenues to overcome colorectal cancer Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-02 Yuancai Xiang, Meng Wang, Hongming Miao
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Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-02 Yajun Duan, Ke Gong, Suowen Xu, Feng Zhang, Xianshe Meng, Jihong Han
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Linking B cell metabolism to immune regulation: the neurotransmitter GABA Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-01 Yang Shi
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Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-01 Fei Xue, Jing Cheng, Yanping Liu, Cheng Cheng, Meng Zhang, Wenhai Sui, Wenqiang Chen, Panpan Hao, Yun Zhang, Cheng Zhang
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APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-08-01 Hongsheng Zhang, Lin Shao, Zhihao Lin, Quan-Xin Long, Huilong Yuan, Lujian Cai, Guangtong Jiang, Xiaoyi Guo, Renzhi Yang, Zepeng Zhang, Bingchang Zhang, Fan Liu, Zhiyong Li, Qilin Ma, Yun-Wu Zhang, Ai-Long Huang, Zhanxiang Wang, Yingjun Zhao, Huaxi Xu
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Cardiomyocytes induced from hiPSCs by well-defined compounds have therapeutic potential in heart failure by secreting PDGF-BB Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-29 Hongmei Li, Fenfang Wu, Guangrui Huang, Di Wu, Ting Wang, Xiashuang Wang, Kai Wang, Yuyin Feng, Anlong Xu
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Radiotherapy combined with immunotherapy: the dawn of cancer treatment Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-29 Zengfu Zhang, Xu Liu, Dawei Chen, Jinming Yu
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Comparative characterization of antibody responses induced by Ad5-vectored spike proteins of emerging SARS-CoV-2 VOCs Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-29 Busen Wang, Jinghan Xu, Shipo Wu, Zhe Zhang, Zhenghao Zhao, Jun Zhang, Ling Fu, Xiaodong Zai, Yudong Wang, Guanying Zhang, ZhengShan Chen, Yi Chen, Hancong Sun, Xiaohong Song, Jinlong Zhang, Lianhui Zhu, Lihua Hou, Wei Chen
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Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-27 Qianqian Li, Li Zhang, Ziteng Liang, Nan Wang, Shuo Liu, Tao Li, Yuanling Yu, Qianqian Cui, Xi Wu, Jianhui Nie, Jiajing Wu, Zhimin Cui, Qiong Lu, Xiangxi Wang, Weijin Huang, Youchun Wang
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Functional isolation, culture and cryopreservation of adult human primary cardiomyocytes Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-27 Bingying Zhou, Xun Shi, Xiaoli Tang, Quanyi Zhao, Le Wang, Fang Yao, Yongfeng Hou, Xianqiang Wang, Wei Feng, Liqing Wang, Xiaogang Sun, Li Wang, Shengshou Hu
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SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl− accumulation in respiratory epithelium Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-27 Lei Chen, Wei-Jie Guan, Zhuo-Er Qiu, Jian-Bang Xu, Xu Bai, Xiao-Chun Hou, Jing Sun, Su Qu, Ze-Xin Huang, Tian-Lun Lei, Zi-Yang Huang, Jincun Zhao, Yun-Xin Zhu, Ke-Nan Ye, Zhao-Rong Lun, Wen-Liang Zhou, Nan-Shan Zhong, Yi-Lin Zhang
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Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-25 Xiaoyan Zhang, Shan Li, Haihua Luo, Shuyue He, Huangda Yang, Lei Li, Tian Tian, Qizheng Han, Jiacong Ye, Chenyang Huang, Aihua Liu, Yong Jiang
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Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-23 Yahya Sohrabi, Holger Reinecke, Oliver Soehnlein
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SARS-CoV-2 infection of monocytes: balancing acts of antibodies and inflammasomes Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-23 R. Camille Brewer, William H. Robinson, Tobias V. Lanz
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TMPRSS2, a novel host-directed drug target against SARS-CoV-2 Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-23 Christian Keller, Eva Böttcher-Friebertshäuser, Michael Lohoff
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Dietary regulation in health and disease Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-23 Qi Wu, Zhi-Jie Gao, Xin Yu, Ping Wang
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Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-22 Keith Al-Hasani, Ishant Khurana, Lina Mariana, Thomas Loudovaris, Scott Maxwell, K. N. Harikrishnan, Jun Okabe, Mark E. Cooper, Assam El-Osta
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Olfactory receptor 2 activation in macrophages: novel mediator of atherosclerosis progression Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-21 Zuowen He, Dao Wen Wang
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The beginning of a new era: pioneering direct screens for RNA modulators Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-21 F. X. Reymond Sutandy, Rebecca George Tharyan, Christian Münch
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RNA-binding protein ZCCHC4 promotes human cancer chemoresistance by disrupting DNA-damage-induced apoptosis Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-20 Ha Zhu, Kun Chen, Yali Chen, Juan Liu, Xiaomin Zhang, Yumei Zhou, Qiuyan Liu, Bingjing Wang, Taoyong Chen, Xuetao Cao
RNA-binding proteins (RBPs) play important roles in cancer development and treatment. However, the tumor-promoting RBPs and their partners, which may potentially serve as the cancer therapeutic targets, need to be further identified. Here, we report that zinc finger CCHC domain-containing protein 4 (ZCCHC4) is of aberrantly high expression in multiple human cancer tissues and is associated with poor
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Back to pluripotency: fully chemically induced reboot of human somatic cells Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-19 Lucas Lange, Miguel A. Esteban, Axel Schambach
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Heterologous mRNA vaccine booster increases neutralization of SARS-CoV-2 Omicron BA.2 variant Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-19 Gen Li, Zhongcheng Zhou, Peng Du, Meixiao Zhan, Ning Li, Xinxin Xiong, Shengjun Tang, Miao Man, Daniel T. Baptista-Hon, Ligong Lu
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Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-19 Shuai Xia, Lijue Wang, Yun Zhu, Lu Lu, Shibo Jiang
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Alveolar macrophages: Achilles’ heel of SARS-CoV-2 infection Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-19 Zhenfeng Wang, Shunshun Li, Bo Huang
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Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-18 Renfa Liu, Shuai Qu, Yunxue Xu, Hanjoong Jo, Zhifei Dai
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ESCRT machinery: role of membrane repair mechanisms in escaping cell death Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-16 Lisa Gregor, Sophia Stock, Sebastian Kobold
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Restored oligodendrogenesis by fibroblast growth factor 17: molecular mechanism for rejuvenating ageing-related memory deficit Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-16 Xiao-Yi Xiong, Alexey Semyanov, Yong Tang
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Epstein-Barr virus infection: the leading cause of multiple sclerosis Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-16 Ruirui He, Yanyun Du, Chenhui Wang
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Hypocretin neuron hyperexcitability in the hypothalamus: a newly discovered culprit in aging-related sleep impairment Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-15 Tianbai Li, Congcong Jia, Weidong Le
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CD24Fc ameliorates immune-related adverse events while preserving anti-tumor therapeutic effect Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-15 Mingyue Liu, Xu Wang, Xuexiang Du, Yan Zhang, Chunxia Ai, Siwen Hu-Lieskovan, Tianhong Li, Martin Devenport, Yang Liu, Pan Zheng
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SeHed, a novel gene expression system with stress-evoked hydrogen peroxide elimination property and anti-aging effect Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-15 Ning Huang, Honghan Chen, Hui Gong, Haoran Tai, Xiaojuan Han, Xiaobo Wang, Chuhui Gong, Tingting Zhao, Yu Yang, Hengyi Xiao
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Correction to: Mesenchymal stem cell-derived small extracellular vesicles mitigate oxidative stress-induced senescence in endothelial cells via regulation of miR-146a/Src Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-14 Xian Xiao, Meiqian Xu, Hongliang Yu, Liping Wang, Xiaoxia Li, Janusz Rak, Shihua Wang, Robert Chunhua Zhao
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Chemoimmunotherapy in advanced esophageal squamous cell carcinoma: optimizing chemotherapy regimens for immunotherapy combinations Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-13 Zhichao Liu, Jun Liu, Zhigang Li
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Umbilical cord artery-derived perivascular stem cells for treatment of ovarian failure through CD146 signaling Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-13 Lu Xu, Yanjun Yang, Lingling Zhang, Guijun Yan, Shiyuan Li, Yifan Li, Yali Hu, Lijun Ding, Bruno Péault, Haixiang Sun
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A new way to maintain CD8+ T-cell quiescence: interaction between CD8α and PILRα Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-12 Ke Jin, Bowen Wu
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SARS-CoV-2 infection and the brain: direct evidence for brain changes in milder cases Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-11 Nico Sollmann, Ambros J. Beer, Frank Kirchhoff
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STING cg16983159 methylation: a key factor for glioblastoma immunosuppression Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-11 Lei Qiu, Yang Meng, Junhong Han
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Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-11 Qilong Li, Quan Yuan, Ning Jiang, Yiwei Zhang, Ziwei Su, Lei Lv, Xiaoyu Sang, Ran Chen, Ying Feng, Qijun Chen
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Nanoparticles in the diagnosis and treatment of vascular aging and related diseases Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-11 Hui Xu, Shuang Li, You-Shuo Liu
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Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications Signal Transduct. Target Ther. (IF 38.104) Pub Date : 2022-07-11 Chen-Chen Jiang, Li-Shan Lin, Sen Long, Xiao-Yan Ke, Kohji Fukunaga, Ying-Mei Lu, Feng Han
更新日期：2022-08-13
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