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CRMP2 phosphorylation regulates polarization and spinal infiltration of CD4+ T lymphocytes, inhibits spinal glial activation, and arthritic pain. Pain (IF 5.9) Pub Date : 2025-04-22 Yue-Peng Jiang,Jun-Jun Wen,Xiao Ma,Cun-Rui Yuan,Feng Zhou,Meng-Jia Zheng,Xin Tang,Xi-Kang Yu,Wei-Dong Lai,Yi-Han Zhou,Wen-Hua Yu,Wen-Ting You,Yan Jin,Ki Duk Park,Rajesh Khanna,Cheng-Ping Wen,Jie Yu
Chronic pain, a hallmark symptom of rheumatoid arthritis (RA), is strongly linked to central sensitization driven by spinal glial cell activation. Despite its clinical significance, the precise mechanisms remain unclear. Recent findings highlight the crucial role of interactions between circulating monocytes and central nervous system glial cells in chronic pain associated with autoimmune conditions
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Enhancing precision in pain management for inflammatory arthritis: exploring the potential role of lidocaine in pain mechanism differentiation. Pain (IF 5.9) Pub Date : 2025-05-01 Jianguo Zhang,Hongwei Jiao
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Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318. Pain (IF 5.9) Pub Date : 2025-04-18 Lisa M Broad,Jeffrey G Suico,P Kellie Turner,Si Nie,Kirk W Johnson,Helen E Sanger,Lindsay A Wegiel,David C Sperry,David Remick,Magdalene Moran,Sam Malekiani,Donato Del Camino,Xinyuan Wu,Jayhong A Chong,Nathaniel T Blair,August V Wilke
The transient receptor potential cation channel member A1 (TRPA1) is heavily implicated in nociceptive signaling in both physiological and pathological pain states. However, it has been challenging to develop TRPA1 antagonists with appropriate properties to advance into clinical development. Herein, we describe the preclinical characterization and early clinical development of LY3526318, a potent,
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Interpretation bias and its relationship with pain: a systematic review and meta-analysis. Pain (IF 5.9) Pub Date : 2025-04-17 Jemma Todd,Brydee Pickup,Daelin Coutts-Bain,Marloes Duijzings,Louise Sharpe
The aim of this review was to systematically review and meta-analyse evidence for the presence of interpretation bias in pain and to establish the likely role of interpretation bias in chronic pain. The primary questions were whether people experiencing pain showed a greater interpretation bias than people without pain and whether interpretation bias was associated with pain outcomes. We were also
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Developing consensus on the most important equity-relevant items to include in pain research: a modified e-Delphi study. Pain (IF 5.9) Pub Date : 2025-04-16 Emma L Karran,Aidan G Cashin,Trevor Barker,Mark A Boyd,Alessandro Chiarotto,Lara J Maxwell,Vina Mohabir,Saurab Sharma,Peter Tugwell,G Lorimer Moseley
There is increasing recognition of the need for routine measurement and reporting of data that can reveal social factors that contribute to health inequities for people with pain. Prioritising what data to collect and understanding how to collect it can be challenging, and no clear guidance exists. We conducted a 3-round Delphi study to develop consensus on the most important items to include in a
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Forebrain networks driving brainstem pain modulatory circuits during nocebo hyperalgesia in healthy humans. Pain (IF 5.9) Pub Date : 2025-04-15 Lewis S Crawford,Sora Yang,Noemi Meylakh,Leana Sattarov,Alister Ramachandran,Vaughan G Macefield,Kevin A Keay,Luke A Henderson
Prior experiences, conditioning cues, and expectations of improvement are essential for nocebo hyperalgesia expression. The neural circuits that communicate with brainstem pain modulatory nuclei during nocebo hyperalgesia responsivity are underexplored. In this study, we employed a classical conditioning and expectation model in 25 healthy human participants and measured brain activity using ultra-high
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Investigating the potential of minocycline in reducing brain inflammation in chronic low back pain: a randomized, placebo-controlled mechanistic clinical trial. Pain (IF 5.9) Pub Date : 2025-04-09 Mehrbod Mohammadian,Erin J Morrissey,Paulina C Knight,Ludovica Brusaferri,Minhae Kim,Nikolaos Efthimiou,Jennifer P Murphy,Zeynab Alshelh,Grace Grmek,Jack H Schnieders,Courtney A Chane,Angelica Sandström,Ciprian Catana,Jodi M Gilman,Joseph J Locascio,Robert R Edwards,Yi Zhang,Vitaly Napadow,Marco L Loggia
Our group has shown that translocator protein (TSPO) levels, a putative marker of neuroinflammation, are increased in the brain and spinal cord of patients with chronic low back pain (cLBP). Whether neuroinflammation might be a therapeutic target for this condition is unknown. In this phase II double-blind, placebo-controlled, randomized clinical trial, we sought to evaluate whether the tetracycline
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Somatosensory profiling to differentiate distinct painful diseases of the pancreas-a quantitative sensory testing case-control study. Pain (IF 5.9) Pub Date : 2025-04-04 Philipp Göltl,Paul Merz,Alexander Schneider,Matthias P Ebert,Michael Hirth,Walter Magerl
Mechanisms of pancreatic pain are insufficiently understood, and quantitative sensory testing (QST) may help to identify the underlying mechanisms. Accordingly, this study assessed comprehensive somatosensory profiles encompassing nociceptive and nonnociceptive parameters in 70 patients with distinct pancreatic diseases, namely acute (n = 23), chronic (n = 20), or autoimmune pancreatitis (n = 10) and
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Ribosome profiling reveals that post-transcriptional control of Nalf1 by heterogeneous nuclear ribonucleoprotein L is required for paclitaxel-induced neuropathic pain. Pain (IF 5.9) Pub Date : 2025-04-02 June Bryan de la Peña,Guadalupe García,Zachary T Campbell
Sensory neurons are integral to the genesis and maintenance of neuropathic pain. The molecular mechanisms that mediate long-lived changes in their excitability are unclear. Here, we leverage functional genomics approaches to survey changes in RNA abundance and translation in dorsal root ganglion neurons from a mouse model of paclitaxel-induced neuropathic pain. We focus specifically on females as paclitaxel
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Differences in the clinical presentation of chronic whiplash-associated disorders and nontraumatic neck pain: a systematic review and meta-analysis. Pain (IF 5.9) Pub Date : 2025-04-01 Junze Chen,Scott F Farrell,Wanyun Irene Huang,Barbara Cagnie,Carlos Murillo,Michele Sterling
Health outcomes may be worse for individuals with whiplash-associated disorders (WAD) compared to nontraumatic neck pain (NTNP), and clinical characteristics may differ. This systematic review examined evidence comparing WAD and NTNP in terms of pain, disability, psychological status, quality of life, measures of nociceptive processing, movement, sensorimotor, and muscle function. Studies were identified
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A revisit of soreness and acidosis-related pain. Pain (IF 5.9) Pub Date : 2025-04-01 I-Wen Su,Chih-Hsien Hung,Jiann-Her Lin,Chih-Cheng Chen
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Effects of sleep and circadian rest-activity rhythms on daily pain severity in women with temporomandibular disorders. Pain (IF 5.9) Pub Date : 2025-03-28 Chung Jung Mun,Siny Tsang,Matthew J Reid,Howard Tennen,Jennifer A Haythornthwaite,Patrick H Finan,Michael T Smith
Although a robust connection between sleep and pain is established, the extent to which circadian rest-activity rhythms contribute toward unique variations in pain, beyond what is elucidated by sleep, remains uncertain. Furthermore, it is largely unknown whether sleep and circadian rest-activity rhythms have interactive effects on daily pain severity. Using wrist actigraphy and daily pain diaries,
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What you don't know can hurt others. A systematic review on calibration of stimulus intensity in pain research. Pain (IF 5.9) Pub Date : 2025-03-27 Julia Badzińska,Magdalena Żegleń,Łukasz Kryst,Przemysław Bąbel
Calibration of pain stimuli is critical in experimental pain research because it makes it possible to adjust stimulus intensity to match individual pain sensitivity. Despite its importance, precise descriptions of calibration procedures are lacking in the literature, thus hindering the ability to replicate studies. The aim of this systematic review is to fill this gap by evaluating and categorizing
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Is a career in science still viable for emerging scholars in pain and health equity? Pain (IF 5.9) Pub Date : 2025-03-20 Troy C Dildine
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Impacts of opioid stewardship in surgical settings: a scoping review. Pain (IF 5.9) Pub Date : 2025-03-20 Dereje Zewdu Assefa,Ting Xia,Yonas Getaye Tefera,Monica Jung,Suzanne Nielsen
Opioid stewardship programs have been implemented in many countries to reduce harms related to prescription opioid use. Yet, there is an evidence gap on the impact of these programs in surgical settings. This systematic scoping review aimed to examine the impact of opioid stewardship on opioid use and clinical outcomes, alongside assessing adherence, and barriers to its implementation in surgical settings
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Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward. Pain (IF 5.9) Pub Date : 2025-03-20 Laura E Simons
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Differential pain perception among females with or without nonspecific chronic low back pain and comorbid insomnia: a quantitative sensory testing analysis. Pain (IF 5.9) Pub Date : 2025-03-20 Jeremy R Chang,Rachel L C Kwan,Eliza R Sun,Shirley X Li,Ping Liang,Jae Q J Liu,Daniel K Y Zheng,Zhixing Zhou,Frank F Huang,Dino Samartzis,Siu Ngor Fu,Arnold Y L Wong
Sleep disturbance is a prevalent condition in individuals with chronic low back pain (CLBP). Despite a strong association between the 2 conditions, the potential mechanisms underlying the role of sleep disturbance in CLBP remain unclear. This case-control study aimed to examine pain perception among females with or without nonspecific CLBP and comorbid insomnia. One hundred females were recruited (mean
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Spontaneous pain dynamics characterized by stochasticity in neural recordings of awake humans with chronic pain. Pain (IF 5.9) Pub Date : 2025-03-20 Jihye Ryu,Jonathan C Kao,Ausaf Bari
Chronic pain is characterized by spontaneous fluctuations in pain intensity, a phenomenon that remains poorly understood. The aim of this study is to elucidate the neural mechanisms underlying pain fluctuations in patients with chronic pain undergoing deep brain stimulation surgery. We recorded local field potentials (LFPs) from pain-processing hub structures, including the ventral posteromedial nucleus
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The precarious use of group data to understand individual processes in pain science. Pain (IF 5.9) Pub Date : 2025-03-19 Johan W S Vlaeyen,Christopher Milde
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International Classification of Diseases-11 chronic pain severity specifiers for children and adolescents: a validation study. Pain (IF 5.9) Pub Date : 2025-03-18 Lisa-Marie Rau,Beatrice Korwisi,Antonia Barke,Benedikt B Claus,Michael Frosch,Boris Zernikow,Julia Wager
The 11th revision of the International Classification of Diseases (ICD-11) now includes separate chronic pain diagnoses that may be extended by chronic pain severity specifiers. These specifiers comprise 3 dimensions-pain intensity, pain-related distress, and pain-related interference-rated on an 11-point numerical rating scale referring to the past 7 days. Like the chronic pain diagnoses, these specifiers
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Are people with chronic pain more diverse than we think? An investigation of ergodicity. Pain (IF 5.9) Pub Date : 2025-03-18 Felicia T A Sundström,Amani Lavefjord,Monica Buhrman,Lance M McCracken
This study investigates whether data from people with endometriosis (n = 58) and fibromyalgia (n = 58) exhibit what is called "ergodicity," meaning that results from analyses of aggregated group data can be used to support conclusions about the individuals within the groups. The variables studied here are commonly investigated in chronic pain: pain intensity, pain interference, depressive symptoms
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Elucidating interplay between myrcene and cannabinoid receptor 1 receptors to produce antinociception in mouse models of neuropathic pain. Pain (IF 5.9) Pub Date : 2025-03-18 Myra Alayoubi,Akeesha Rodrigues,Christine Wu,Ella Whitehouse,Jessica Nguyen,Ziva D Cooper,Patrick R O'Neill,Catherine M Cahill
The need for nonaddictive and effective treatments for chronic pain are at an all-time high. Historical precedence, and now clinical evidence, supports the use of cannabis for alleviating chronic pain. A plethora of research on delta-9-tetrahydrocannabinol exists, yet cannabis is comprised of a multitude of constituents, some of which possess analgesic potential, that have not been systematically investigated
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Unrelieved pain and risk of opioid use disorder or overdose in older adults prescribed opioids. Pain (IF 5.9) Pub Date : 2025-03-18 Yu-Jung Jenny Wei,Siegfried Schmidt,Roger B Fillingim,Guy Brock,Stephan Schmidt,Almut G Winterstein
It is unclear to what extent unrelieved pain, the most common motive for prescription opioid misuse, is associated with risks of opioid use disorder (OUD) and opioid overdose (OD) among older adults with prescribed opioids. This retrospective cohort study was conducted among Health and Retirement Study (HRS) participants with linked Medicare claims data between 2006 and 2021. Participants aged 65 years
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Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain. Pain (IF 5.9) Pub Date : 2025-03-17 Giada Mascio,Serena Notartomaso,Roxana Paula Ginerete,Tiziana Imbriglio,Domenico Bucci,Francesca Liberatore,Alessia Ceccherelli,Sonia Castaldi,Gloria Zampini,Milena Cannella,Ferdinando Nicoletti,Giuseppe Battaglia,Valeria Bruno
We moved from the hypothesis that perineuronal nets (PNNs), which are condensed structures of the extracellular matrix surrounding GABAergic interneurons in the forebrain, contribute to mechanisms of maladaptive neuronal plasticity underlying chronic pain. Here, we found that the density of PNNs labelled with the lectin Wisteria Floribunda Agglutinin (WFA) increased in the contralateral somatosensory
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Neural biomarkers of pain: defining perspectives and limitations of peak alpha frequency. Pain (IF 5.9) Pub Date : 2025-03-14 Giulia Liberati
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Exploring the interactions between circadian rhythms and sleep on pain: a call to action. Pain (IF 5.9) Pub Date : 2025-03-13 Cassandra Goldfarb,Christopher D King
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Moderators of digital cognitive-behavioral therapy for youth with sickle cell disease pain: secondary analysis of a randomized controlled trial. Pain (IF 5.9) Pub Date : 2025-03-13 Tonya M Palermo,Kavin Srinakarin,Chuan Zhou,Chitra Lalloo,Carlton Dampier,William T Zempsky,Sherif M Badawy,Nitya Bakshi,Yeon Joo Ko,Fareha Nishat,Jennifer N Stinson
Pain is the hallmark symptom of sickle cell disease (SCD). By adolescence, 20% of youth with SCD develop chronic SCD pain. Our randomized controlled trial found significant reductions in pain in youth receiving digital cognitive-behavioral therapy (CBT) vs education control. However, little is known about factors that moderate the effects of CBT in adolescents with SCD. This secondary data analysis
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Deep learning modelling of structural brain MRI in chronic head and neck pain after mild TBI. Pain (IF 5.9) Pub Date : 2025-03-12 Sivan Attias,Roni Ramon-Gonen,Yaara Erez,Noam Bosak,Yelena Granovsky,Shahar Shelly
Chronic headache is a common complication after mild traumatic brain injury (mTBI), which affects close to 70 million individuals annually worldwide. This study aims to test the utility of a unique, early predictive magnetic resonance imaging (MRI)-based classification model using structural brain MRI scans, a rarely used approach to identify high-risk individuals for post-mTBI chronic pain. We recruited
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Maintenance of treatment gains from psychological treatments for chronic pain: what (little) we know, and the urgent need to extend it. Pain (IF 5.9) Pub Date : 2025-03-11 Caroline S Dorfman,Alicia A Heapy,Amanda C de C Williams,Francis J Keefe
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TRESK background potassium channel regulates MrgprA3 + pruriceptor excitability, acute and chronic itch. Pain (IF 5.9) Pub Date : 2025-03-06 Júlia Llimós-Aubach,Alba Andres-Bilbe,Anna Pujol-Coma,Aida Castellanos,Irene Pallás,Maria Isabel Bahamonde,Josep Maria de Anta,Concepció Soler,Núria Comes,Gerard Callejo,Xavier Gasull
A subset of peripheral sensory neurons expressing specific Mas-related G-protein-coupled receptors and transient receptor potential channels mediate pruritogen-induced chemical itch. However, the molecular mechanisms that regulate the excitability of these cells, and consequently itch sensation, are poorly understood. TWIK-related spinal cord K + channel (TRESK) is a background K + channel that modulates
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Pain sensation and emotion induced by aromatase inhibitors: a new mouse model. Pain (IF 5.9) Pub Date : 2025-03-05 Huifang Li,Linjiang Han,Pei Li,Dan Lu,Yi Feng
Aromatase inhibitors (AIs) are crucial for hormone receptor-positive breast cancer patients, enhancing disease-free survival and significantly reducing the risk of distant metastasis and local recurrence. However, AI-induced pain and emotional distress can impair the quality of life and medication adherence, leading to premature discontinuation and increased mortality. In this study, we developed a
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Factors influencing the hypoalgesic effects of virtual reality. Pain (IF 5.9) Pub Date : 2025-03-04 Roni Shafir,Lakota Watson,Ryan B Felix,Salim Muhammed,John P Fisher,Peter Hu,Yang Wang,Luana Colloca
Virtual reality (VR) is a promising intervention for both experimentally induced and clinical pain, but the factors contributing to the efficacy of VR remain relatively unclear, partially because selecting adequate controls in existing VR studies is challenging. Here, we identified and isolated several factors potentially influencing the hypoalgesic effect of VR. In this within-subjects, counterbalanced
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Evidence for peripheral neuroinflammation after acute whiplash. Pain (IF 5.9) Pub Date : 2025-03-04 Colette Ridehalgh,Joel Fundaun,Stephen Bremner,Mara Cercignani,Soraya Koushesh,Rupert Young,Alex Novak,Jane Greening,Annina B Schmid,Andrew Dilley
Whiplash injury is associated with high socioeconomic costs and poor prognosis. Most people are classified as having whiplash-associated disorder grade II (WADII), with neck complaints and musculoskeletal signs, in the absence of frank neurological signs. However, evidence suggests that there is a subgroup with underlying nerve involvement in WADII, such as peripheral neuroinflammation. This study
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Evaluating maintenance of treatment effects: a call to action. Pain (IF 5.9) Pub Date : 2025-03-03 Brian E McGuire,Helena K Lydon
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A within-subject, double-blind, placebo-controlled randomized evaluation of the combined effects of cannabidiol and hydromorphone in a human laboratory pain model. Pain (IF 5.9) Pub Date : 2025-02-28 Cecilia L Bergeria,Chung Jung Mun,Traci J Speed,Andrew S Huhn,David Wolinsky,Ryan Vandrey,Claudia M Campbell,Kelly E Dunn
Preclinical and epidemiological evidence supports that cannabinoids may have opioid-sparing properties and could be one strategy to decrease opioid use and associated harms like overdose and extramedical use. The objective of this within subjects, double-blind, double-dummy, randomized human laboratory trial was to examine whether cannabidiol (CBD) increases opioid analgesic effects and whether there
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Inequities time-to-follow-up care and administrative action after low back pain diagnosis in active duty service members. Pain (IF 5.9) Pub Date : 2025-02-28 Janiece Taylor,Letitia Travaglini,Megan O'Connell,Patricia K Carreño,Germaine F Herrera,Alexander G Velosky,Maxwell Amoako,Ryan C Costantino,Krista B Highland
As healthcare systems adopt data-driven methods to determine resource allocation for treating low back pain (LBP), it is critical to evaluate equity in time-to-follow-up care after an index visit and long-term occupational outcomes. This retrospective observational study included medical records of 525,252 active duty US service members who received an LBP index diagnosis from June 2016 to February
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Perineuronal nets in the brain: new vistas in pain mechanisms. Pain (IF 5.9) Pub Date : 2025-02-25 Volker Neugebauer,Nico Antenucci
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Where is the pain? Spatial patterns of pain co-occurrence in a population-based study of 4833 pain drawings incorporating network analysis. Pain (IF 5.9) Pub Date : 2025-02-25 David William Evans,Bernard Xian Wei Liew,Johan Hviid Andersen,Søren Mose
Spatial pain patterns are widely used as diagnostic tools, yet population-level estimates, such as the prevalence of pain in specific body regions and likelihood of their co-occurrence, are lacking. Despite this, bilateral limb pain is considered relatively uncommon. Baseline data from a population-based Danish cohort were analysed. Twenty-one pain drawing regions, coded as binary "pain"/"no-pain"
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Ronald Dubner: pioneer in pain research, founding member of the International Association for the Study of Pain, and former Editor-in-Chief of PAIN. Pain (IF 5.9) Pub Date : 2025-02-25 Barry J Sessle
Ronald Dubner (1934-2023) was a "giant" in the field of pain. His more than 5 decades of research programs at the US National Institutes of Health and the University of Maryland resulted in important discoveries that considerably advanced our understanding of the neural and nonneural processes underlying acute and chronic pain and their behavioral and clinical correlates. Through his multidisciplinary
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Give and take: an evolutionary framework for social transactions in pain. Pain (IF 5.9) Pub Date : 2025-02-21 Judith Kappesser,Amanda C de C Williams
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Interpersonal dyadic influences on transitions between pain states: a narrative review and synthesis. Pain (IF 5.9) Pub Date : 2025-02-21 Hollie Birkinshaw,Amanda C de C Williams,Claire Friedrich,Charlotte Lee,Edmund Keogh,Christopher Eccleston,Tamar Pincus
Pain is not experienced in isolation; it is affected by and affects other people. Interactions between parents and partners and people living with pain affect beliefs, emotions and behaviours, and pain progress and change. We searched systematically for longitudinal studies of associations between specific familial, dyadic, interpersonal factors and quantitative pain transitions. We coded studies for
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Epidermal Transient Receptor Potential Vanilloid 1 innervation is increased in patients with painful diabetic polyneuropathy experiencing ongoing burning pain. Pain (IF 5.9) Pub Date : 2025-02-19 Eleonora Galosi, Pietro Falco, Giuseppe Di Pietro, Nicoletta Esposito, Gianfranco De Stefano, Enrico Evangelisti, Caterina Leone, Daniel Litewczuk, Lorenzo Tramontana, Giulia Di Stefano, Andrea Truini
Preclinical studies suggested that Transient Receptor Potential Vanilloid 1 (TRPV1) channels contribute to neuropathic pain in animal models of diabetic polyneuropathy. Patients with painful diabetic polyneuropathy commonly experience ongoing burning pain. This study aimed at evaluating the association between this specific type of pain and TRPV1 intraepidermal nerve fibers in patients with painful
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Dysmenorrhea and the clinical encounter: testing a conceptual model of physician-patient interactions among emerging adults. Pain (IF 5.9) Pub Date : 2025-02-19 Alexandra R Brilz, Michelle M Gagnon
Dysmenorrhea affects as much as 85% of female youth in Canada and the United States and can negatively impact academic performance, overall health, and mental well-being. The physician-patient relationship can play an important role in supporting patients with pain conditions, such as dysmenorrhea. Through effective communication, trust, and validation, physician-patient interactions can empower pain
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The value of equity, diversity, and inclusion principles and sex/gender considerations in pain research. Pain (IF 5.9) Pub Date : 2025-02-19 Karen Deborah Davis
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Pain experience of children with Christianson syndrome. Pain (IF 5.9) Pub Date : 2025-02-19 Shajenth Premachandran, Don Daniel Ocay, Claudie Beaulieu, Jonathan Balduzzi, Diana-Luk Ye, Albena Davidova, Rakan Bokhari, Jean A Ouellet, John Orlowski, Louis Gendron, Reza Sharif-Naeini, Catherine E Ferland
Children with Christianson syndrome (CS), an X-linked neurodevelopmental disorder caused by loss-of-function mutations in the alkali cation/proton exchanger SLC9A6/NHE6, display severe cognitive impairments, mutism, and sensory abnormalities such as hyposensitivity to pain. However, it is unclear whether these children display other sensory abnormalities and whether their pain hyposensitivity is the
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Mast cell chymases: essential for preventing the transition from acute to chronic pain. Pain (IF 5.9) Pub Date : 2025-02-18 Erick J Rodríguez-Palma,Rajesh Khanna
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Set and setting in mind-body interventions for pain: lessons from an experimental evaluation of virtual reality. Pain (IF 5.9) Pub Date : 2025-02-18 Patrick H Finan
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Advancements and prospects of transcranial focused ultrasound in pain neuromodulation. Pain (IF 5.9) Pub Date : 2025-02-18 Yu Shi, Wen Wu
Transcranial focused ultrasound (tFUS) is an emerging noninvasive neuromodulation technology that has shown great potential in pain modulation. This review systematically elucidates the multilevel biological mechanisms of tFUS neuromodulation, from network-wide effects to cellular and molecular processes, as well as broader systemic influences. Preliminary animal pain model studies have revealed tFUS's
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Cortical reorganization in neuropathic pain due to peripheral nerve degeneration: altered cortical surface morphometry and hierarchical topography. Pain (IF 5.9) Pub Date : 2025-02-18 Chien-Ho Janice Lin, Hsueh-Wen Hsueh, Ming-Chang Chiang, Sung-Tsang Hsieh, Chi-Chao Chao
Degeneration of peripheral nerves causes neuropathic pain. Previous studies have documented structural and functional brain alterations in peripheral neuropathy, which may be attributed to maladaptive plasticity following chronic neuropathic pain. Nevertheless, the effects of peripheral neuropathic pain on the macroscale organization of the cerebral cortex have not been explored. This study investigated
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Experimentally induced central sensitization is accompanied by alterations in electroencephalographical microstate parameters. Pain (IF 5.9) Pub Date : 2025-02-18 Ketan Prafull Jaltare, Diana M Torta
Pain perception is a dynamic and time-varying phenomenon. The high temporal resolution of electroencephalography (EEG) can be leveraged to gain insight into its cortical dynamics. Electroencephalography microstate analysis is a novel technique that parses multichannel EEG signals into a limited number of quasi-stable topographies (microstates) that have a meaningful temporal structure and have been
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Early opioid administration and pain-related patient-reported outcomes on the first postoperative day: an analysis of data from 111,693 patients in 392 surgical wards in Germany. Pain (IF 5.9) Pub Date : 2025-02-18 Philipp Baumbach, Ruth Zaslansky, Johannes Dreiling, Marcus Komann, Christin Arnold, Ulrike M Stamer, Claudia Weinmann, Winfried Meissner
The risk-benefit ratio of perioperative opioid analgesia is controversial. Few studies have analyzed the effectiveness of opioids in the early postoperative period. To analyze the effectiveness of early opioid administration in this period in a large number of surgeries in routine care, we compared pain-related outcomes between patients treated on wards with different rates of early opioid administration
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Widespread pain phenotypes impact treatment efficacy results in randomized clinical trials for interstitial cystitis/bladder pain syndrome: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain network study. Pain (IF 5.9) Pub Date : 2025-02-18 John T Farrar, Kenneth T Locke, J Quentin Clemens, James W Griffith, Steven E Harte, Ziya Kirkali, Karl J Kreder, John N Krieger, H Henry Lai, Robert M Moldwin, Chris Mullins, Bruce D Naliboff, Michel A Pontari, Larissa V Rodríguez, Anthony J Schaeffer, Andrew Schrepf, Alisa Stephens-Shields, Siobhan Sutcliffe, Bayley J Taple, David A Williams, J Richard Landis
Pain clinical trials are notoriously complex and often inefficient in demonstrating efficacy, even for known efficacious treatments. A major issue is the difficulty in the a priori identification of specific phenotypes to include in the study population. Recent work has identified the extent of widespread pain as an important determinant of the likelihood of response to therapy, but it has not been
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Sex differences in chromatin structure within the dorsal root ganglion. Pain (IF 5.9) Pub Date : 2025-03-01 Michael J Iadarola,Matthew R Sapio,Peter D Burbelo
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Interoception and pain: body-mind integration, rupture, and repair. Pain (IF 5.9) Pub Date : 2025-02-06 Sarah N Garfinkel,Christopher Eccleston
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Somatosensory and clinical profiles of patients with spine-related and clinical framework-based neck-arm pain. Pain (IF 5.9) Pub Date : 2025-02-05 Camilla Kapitza, Nikolaus Ballenberger, Kerstin Luedtke, Annina B Schmid, Brigitte Tampin
Spine-related neck-arm pain is heterogeneous and may present on a spectrum between nociceptive and neuropathic pain. A recently developed mechanism-based clinical framework for spine-related pain distinguishes between spinally referred pain without neurological deficits (somatic referred pain, heightened nerve mechanosensitivity, radicular pain), with neurological deficits (radiculopathy), and mixed-pain
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Autoantibodies in patients with fibromyalgia syndrome. Pain (IF 5.9) Pub Date : 2025-02-05 Sabine Seefried, Anastasia Barcic, Maria Fernanda Grijalva Yepez, Lena Reinhardt, Luise Appeltshauser, Kathrin Doppler, Nurcan Üçeyler, Claudia Sommer
The objective of this study was to assess the frequency of IgG autoantibodies in patients with fibromyalgia syndrome (FMS), to characterize their binding to dorsal root ganglion (DRG) neurons and glial cells, and to assess whether specific DRG binding patterns correlate with clinical symptoms. Sera of a cohort of 184 patients with FMS and 55 control sera were used to test binding of patient IgG on
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Social determinants of health in pediatric chronic postsurgical pain research. Pain (IF 5.9) Pub Date : 2025-02-05 Wendy Gaultney,Nathalia Jimenez,Abraham Correa-Medina,Claudia M Campbell,Jennifer Anne Rabbitts
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Conditioned pain modulation: controlling for the order of baseline and conditioning. Pain (IF 5.9) Pub Date : 2025-02-04 Stefan Lautenbacher, Claudia Horn-Hofmann, Miriam Kunz
Conditioned pain modulation (CPM) is assumed to capture endogenous pain modulation. In standard CPM designs, the evaluation of a painful test stimulus (TS) (baseline) is followed by a second evaluation of the TS during/after application of a painful conditioning stimulus (CS) (treatment). However, these standard CPM within designs (baseline always preceding treatment) do not control for order effects
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PI3K-mediated Kif1a DNA methylation contributes to neuropathic pain: an in vivo study. Pain (IF 5.9) Pub Date : 2025-02-04 Wei Jiang, Peng Yu, Yu Yang, Meng-Tan Cai, Lin Gan, Kang Qu, Ying-Ying Cheng, Ming Dong
Neuropathic pain (NP) is a chronic condition caused by nerve injuries, such as nerve compression. Understanding its underlying neurobiological mechanisms is critical for developing effective treatments. Previous studies have shown that Kinesin family member 1A (Kif1a) heterozygous deficient mice display sensory deficits in response to nociceptive stimuli. PI3K has been found to mitigate these sensory
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An examination of acrylamide and cadmium as possible mediators of the association between cigarette smoking and chronic musculoskeletal pain. Pain (IF 5.9) Pub Date : 2025-02-03 Codjo Djignefa Djade, Caroline Diorio, Danielle Laurin, Denis Talbot, Pierre-Hugues Carmichael, Clermont E Dionne
Chronic musculoskeletal pain (CMP) causes significant health loss worldwide and is one of the major public health issues of our time. Cigarette smoking is an independent risk factor of CMP. The present study examined the potential mediating role of 2 subproducts of cigarette smoke, acrylamide and cadmium, individually and combined, on the association between cigarette smoking and CMP, using the Inverse