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An open-source framework for electronic health record and patient fate exploration Nat. Med. (IF 58.7) Pub Date : 2024-09-25
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A foundation model for clinician-centered drug repurposing Nat. Med. (IF 58.7) Pub Date : 2024-09-25 Kexin Huang, Payal Chandak, Qianwen Wang, Shreyas Havaldar, Akhil Vaid, Jure Leskovec, Girish N. Nadkarni, Benjamin S. Glicksberg, Nils Gehlenborg, Marinka Zitnik
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Disparities in healthy working life expectancy in different Chinese populations Nat. Med. (IF 58.7) Pub Date : 2024-09-24
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Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction Nat. Med. (IF 58.7) Pub Date : 2024-09-23 Greta K. Wood, Brendan F. Sargent, Zain-Ul-Abideen Ahmad, Kukatharmini Tharmaratnam, Cordelia Dunai, Franklyn N. Egbe, Naomi H. Martin, Bethany Facer, Sophie L. Pendered, Henry C. Rogers, Christopher Hübel, Daniel J. van Wamelen, Richard A. I. Bethlehem, Valentina Giunchiglia, Peter J. Hellyer, William Trender, Gursharan Kalsi, Edward Needham, Ava Easton, Thomas A. Jackson, Colm Cunningham, Rachel
The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the one-year cognitive, serum biomarker, and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who had required hospitalisation, compared to 2,927 normative matched
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Patient attitudes toward the AI doctor Nat. Med. (IF 58.7) Pub Date : 2024-09-23 Aaron Fanous, Kirsten Steffner, Roxana Daneshjou
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Molecular profiling of BRAF-V600E-mutant metastatic colorectal cancer in the phase 3 BEACON CRC trial Nat. Med. (IF 58.7) Pub Date : 2024-09-23 Scott Kopetz, Danielle A. Murphy, Jie Pu, Fortunato Ciardiello, Jayesh Desai, Eric Van Cutsem, Harpreet Singh Wasan, Takayuki Yoshino, Hedieh Saffari, Xiaosong Zhang, Phineas Hamilton, Tao Xie, Rona Yaeger, Josep Tabernero
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A toolbox for surfacing health equity harms and biases in large language models Nat. Med. (IF 58.7) Pub Date : 2024-09-23 Stephen R. Pfohl, Heather Cole-Lewis, Rory Sayres, Darlene Neal, Mercy Asiedu, Awa Dieng, Nenad Tomasev, Qazi Mamunur Rashid, Shekoofeh Azizi, Negar Rostamzadeh, Liam G. McCoy, Leo Anthony Celi, Yun Liu, Mike Schaekermann, Alanna Walton, Alicia Parrish, Chirag Nagpal, Preeti Singh, Akeiylah Dewitt, Philip Mansfield, Sushant Prakash, Katherine Heller, Alan Karthikesalingam, Christopher Semturs, Joelle
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High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity Nat. Med. (IF 58.7) Pub Date : 2024-09-20 Sohyon Lee, Tobias Weiss, Marcel Bühler, Julien Mena, Zuzanna Lottenbach, Rebekka Wegmann, Miaomiao Sun, Michel Bihl, Bartłomiej Augustynek, Sven P. Baumann, Sandra Goetze, Audrey van Drogen, Patrick G. A. Pedrioli, David Penton, Yasmin Festl, Alicia Buck, Daniel Kirschenbaum, Anna M. Zeitlberger, Marian C. Neidert, Flavio Vasella, Elisabeth J. Rushing, Bernd Wollscheid, Matthias A. Hediger, Michael
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Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity Nat. Med. (IF 58.7) Pub Date : 2024-09-20 Yun Huang, Karolina Sulek, Sara E. Stinson, Louise Aas Holm, Min Kim, Kajetan Trost, Kourosh Hooshmand, Morten Asp Vonsild Lund, Cilius E. Fonvig, Helene Bæk Juel, Trine Nielsen, Lars Ängquist, Peter Rossing, Maja Thiele, Aleksander Krag, Jens-Christian Holm, Cristina Legido-Quigley, Torben Hansen
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siRNA therapy lowers triglycerides in patients with rare condition Nat. Med. (IF 58.7) Pub Date : 2024-09-19
Plozasiran reduced triglyceride levels by 80% and lowered the risk of pancreatitis in patients with persistent chylomicronemia, with or without a genetic diagnosis.
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Echocardiographic screening for heart failure and optimization of the care pathway for individuals with pacemakers: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2024-09-19 Maria F. Paton, John Gierula, Haqeel A. Jamil, Sam Straw, Judith E. Lowry, Rowena Byrom, Thomas A. Slater, Alasdair M. Fellows, Richard G. Gillott, Hemant Chumun, Paul Smith, Richard M. Cubbon, Deborah D. Stocken, Mark T. Kearney, Klaus K. Witte
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Improving primary healthcare with generative AI Nat. Med. (IF 58.7) Pub Date : 2024-09-18 Winnie Yip
Studies in China show how large language models can improve primary healthcare systems, but equitably scaling this technology will require attention to rural, low-resource settings and the companion policies that support its implementation.
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Navigating treatment combinations in small-cell lung cancer Nat. Med. (IF 58.7) Pub Date : 2024-09-18 Ning Li, Si-Yu Wang
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Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region Nat. Med. (IF 58.7) Pub Date : 2024-09-18 Felipe Gomes Naveca, Tatiana Amaral Pires de Almeida, Victor Souza, Valdinete Nascimento, Dejanane Silva, Fernanda Nascimento, Matilde Mejía, Yasmin Silva de Oliveira, Luisa Rocha, Natana Xavier, Janis Lopes, Rodrigo Maito, Cátia Meneses, Tatyana Amorim, Luciana Fé, Fernanda Sindeaux Camelo, Samyly Coutinho de Aguiar Silva, Alexsandro Xavier de Melo, Leíse Gomes Fernandes, Marco Aurélio Almeida de
The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. Here, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia, and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current
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Countering the impact of the climate crisis on health will require data Nat. Med. (IF 58.7) Pub Date : 2024-09-17
As drastically rising global temperatures threaten the health and wellbeing of populations, solutions that drive policy action must be based on scientific evidence of which strategies work in different scenarios.
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Exposure to extreme heat increases perinatal mortality in sub-Saharan Africa Nat. Med. (IF 58.7) Pub Date : 2024-09-17
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Data-driven risk stratification and precision management of pulmonary nodules detected on chest computed tomography Nat. Med. (IF 58.7) Pub Date : 2024-09-17 Chengdi Wang, Jun Shao, Yichu He, Jiaojiao Wu, Xingting Liu, Liuqing Yang, Ying Wei, Xiang Sean Zhou, Yiqiang Zhan, Feng Shi, Dinggang Shen, Weimin Li
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Author Correction: Not all AI health tools with regulatory authorization are clinically validated Nat. Med. (IF 58.7) Pub Date : 2024-09-16 Sammy Chouffani El Fassi, Adonis Abdullah, Ying Fang, Sarabesh Natarajan, Awab Bin Masroor, Naya Kayali, Simran Prakash, Gail E. Henderson
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03203-3, published online 26 August 2024.
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Author Correction: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations Nat. Med. (IF 58.7) Pub Date : 2024-09-16 Sebastian Moguilner, Sandra Baez, Hernan Hernandez, Joaquín Migeot, Agustina Legaz, Raul Gonzalez-Gomez, Francesca R. Farina, Pavel Prado, Jhosmary Cuadros, Enzo Tagliazucchi, Florencia Altschuler, Marcelo Adrián Maito, María E. Godoy, Josephine Cruzat, Pedro A. Valdes-Sosa, Francisco Lopera, John Fredy Ochoa-Gómez, Alfredis Gonzalez Hernandez, Jasmin Bonilla-Santos, Rodrigo A. Gonzalez-Montealegre
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03209-x, published online 26 August 2024.
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ctDNA-based molecular residual disease and survival in resectable colorectal cancer Nat. Med. (IF 58.7) Pub Date : 2024-09-16 Yoshiaki Nakamura, Jun Watanabe, Naoya Akazawa, Keiji Hirata, Kozo Kataoka, Mitsuru Yokota, Kentaro Kato, Masahito Kotaka, Yoshinori Kagawa, Kun-Huei Yeh, Saori Mishima, Hiroki Yukami, Koji Ando, Masaaki Miyo, Toshihiro Misumi, Kentaro Yamazaki, Hiromichi Ebi, Kenji Okita, Atsushi Hamabe, Hiroki Sokuoka, Satoshi Kobayashi, George Laliotis, Vasily N. Aushev, Shruti Sharma, Adham Jurdi, Minetta C. Liu
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Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial Nat. Med. (IF 58.7) Pub Date : 2024-09-16 Iris Nederlof, Olga I. Isaeva, Manon de Graaf, Robbert C. A. M. Gielen, Noor A. M. Bakker, Adrianne L. Rolfes, Hannah Garner, Bram Boeckx, Joleen J. H. Traets, Ingrid A. M. Mandjes, Michiel de Maaker, Thomas van Brussel, Maksim Chelushkin, Elisa Champanhet, Marta Lopez-Yurda, Koen van de Vijver, José G. van den Berg, Ingrid Hofland, Natasja Klioueva, Ritse M. Mann, Claudette E. Loo, Frederieke H. van
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Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors Nat. Med. (IF 58.7) Pub Date : 2024-09-16 Yoshiaki Nakamura, Hiroshi Ozaki, Makoto Ueno, Yoshito Komatsu, Satoshi Yuki, Taito Esaki, Hiroya Taniguchi, Yu Sunakawa, Kensei Yamaguchi, Ken Kato, Tadamichi Denda, Tomohiro Nishina, Naoki Takahashi, Taroh Satoh, Hisateru Yasui, Hironaga Satake, Eiji Oki, Takeshi Kato, Takashi Ohta, Nobuhisa Matsuhashi, Masahiro Goto, Naohiro Okano, Koushiro Ohtsubo, Kentaro Yamazaki, Riu Yamashita, Naoko Iida, Mihoko
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Neoadjuvant nivolumab and relatlimab in locally advanced MMR-deficient colon cancer: a phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2024-09-15 Peter G. M. de Gooyer, Yara L. Verschoor, Lauren D. W. van den Dungen, Sara Balduzzi, Hendrik A. Marsman, Marnix H. Geukes Foppen, Cecile Grootscholten, Simone Dokter, Anne G. den Hartog, Wieke H. M. Verbeek, Karlijn Woensdregt, Joris J. van den Broek, Steven J. Oosterling, Ton N. Schumacher, Koert F. D. Kuhlmann, Regina G. H. Beets-Tan, John B. A. G. Haanen, Monique E. van Leerdam, Jose G. van den
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Datopotamab–deruxtecan in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2024-09-14 Katia Khoury, Jane L. Meisel, Christina Yau, Hope S. Rugo, Rita Nanda, Marie Davidian, Butch Tsiatis, A. Jo Chien, Anne M. Wallace, Mili Arora, Mariya Rozenblit, Dawn L. Hershman, Alexandra Zimmer, Amy S. Clark, Heather Beckwith, Anthony D. Elias, Erica Stringer-Reasor, Judy C. Boughey, Chaitali Nangia, Christos Vaklavas, Coral Omene, Kathy S. Albain, Kevin M. Kalinsky, Claudine Isaacs, Jennifer Tseng
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Datopotamab–deruxtecan plus durvalumab in early-stage breast cancer: the sequential multiple assignment randomized I-SPY2.2 phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2024-09-14 Rebecca A. Shatsky, Meghna S. Trivedi, Christina Yau, Rita Nanda, Hope S. Rugo, Marie Davidian, Butch Tsiatis, Anne M. Wallace, A. Jo Chien, Erica Stringer-Reasor, Judy C. Boughey, Coral Omene, Mariya Rozenblit, Kevin Kalinsky, Anthony D. Elias, Christos Vaklavas, Heather Beckwith, Nicole Williams, Mili Arora, Chaitali Nangia, Evanthia T. Roussos Torres, Brittani Thomas, Kathy S. Albain, Amy S. Clark
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Advancing ASO therapies from development to implementation Nat. Med. (IF 58.7) Pub Date : 2024-09-13 Rebecca Schuele, Matthis Synofzik, Holm Graessner, Annemieke Aartsma-Rus
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Post-approval evidence generation: a shared responsibility for healthcare Nat. Med. (IF 58.7) Pub Date : 2024-09-13 Ali Abbasi, Donna Rivera, Lesley H. Curtis, Robert M. Califf
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Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial Nat. Med. (IF 58.7) Pub Date : 2024-09-13 Nadia Harbeck, Eva Ciruelos, Guy Jerusalem, Volkmar Müller, Naoki Niikura, Giuseppe Viale, Rupert Bartsch, Christian Kurzeder, Michaela J. Higgins, Roisin M. Connolly, Sally Baron-Hay, María Gión, Valentina Guarneri, Giampaolo Bianchini, Hans Wildiers, Santiago Escrivá-de-Romaní, Manoj Prahladan, Helen Bridge, Nataliya Kuptsova-Clarkson, Nana Scotto, Sunil Verma, Nancy U. Lin
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Initiating second-trimester medical abortions at home Nat. Med. (IF 58.7) Pub Date : 2024-09-12
In people undergoing medical abortion after 12 weeks of pregnancy, those who took the first dose of misoprostol at home were less likely to require overnight hospitalization.
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The European Health Data Space can be a boost for research beyond borders Nat. Med. (IF 58.7) Pub Date : 2024-09-12 Andrea Ganna, Angel Carracedo, Christian F. Christiansen, Emanuele Di Angelantonio, Pearl A. Dykstra, Angel M. Dzhambov, Roland Eils, Sara Green, Katharina L. Schneider, Tibor V. Varga, Anna-Leena Vuorinen, Luisa Zuccolo, Naja Hulvej Rod, Klaus Hoeyer
The European Health Data Space provides an opportunity to benefit patients and the public.
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An open-source framework for end-to-end analysis of electronic health record data Nat. Med. (IF 58.7) Pub Date : 2024-09-12 Lukas Heumos, Philipp Ehmele, Tim Treis, Julius Upmeier zu Belzen, Eljas Roellin, Lilly May, Altana Namsaraeva, Nastassya Horlava, Vladimir A. Shitov, Xinyue Zhang, Luke Zappia, Rainer Knoll, Niklas J. Lang, Leon Hetzel, Isaac Virshup, Lisa Sikkema, Fabiola Curion, Roland Eils, Herbert B. Schiller, Anne Hilgendorff, Fabian J. Theis
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Safety and antiviral effect of a triple combination of HIV-1 broadly neutralizing antibodies: a phase 1/2a trial Nat. Med. (IF 58.7) Pub Date : 2024-09-12 Boris Julg, Victoria E. K. Walker-Sperling, Kshitij Wagh, Malika Aid, Kathryn E. Stephenson, Rebecca Zash, Jinyan Liu, Joseph P. Nkolola, Amelia Hoyt, Mike Castro, Leonid Serebryannyy, Katherine Yanosick, Tessa Speidel, Erica N. Borducchi, Tetyana Murzda, Lori Maxfield, Roberto Arduino, Adrian B. McDermott, Lucio Gama, Elena E. Giorgi, Richard A. Koup, Michael S. Seaman, Charlotte-Paige Rolle, Edwin
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Prenatal exposure to famine affects lifelong health Nat. Med. (IF 58.7) Pub Date : 2024-09-09
Analysis of data related to the Ukraine famine of 1932–1933 shows that in utero exposure to famine increases the risk of adult type 2 diabetes by more than twofold.
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Cardiovascular safety of vitamin B3 administration Nat. Med. (IF 58.7) Pub Date : 2024-09-05 Stefan Schreiber, Georg H. Waetzig, Matthias Laudes, Philip Rosenstiel
arising from M. Ferrell et al. Nature Medicine https://doi.org/10.1038/s41591-023-02793-8 (2024) Ferrell et al.1 recently reported associations between serum levels of the terminal niacin metabolites N1-methyl-2-pyridone-5-carboxamide (2PY) and N1-methyl-4-pyridone-3-carboxamide (4PY) with an increased 3-year incident risk of major adverse cardiovascular events. The association of 4PY with cardiovascular
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Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al. Nat. Med. (IF 58.7) Pub Date : 2024-09-05 W. H. Wilson Tang, Joseph A. DiDonato, Hooman Allayee, Stanley L. Hazen
replying to J. R. Guyton & W. E. Boden Nature Medicine https://doi.org/10.1038/s41591-024-03220-2 (2024) replying to S. Schreiber et al. Nature Medicine https://doi.org/10.1038/s41591-024-03219-9 (2024)
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Medicine’s DEI backlash offers an opportunity to refocus on evidence-based approaches Nat. Med. (IF 58.7) Pub Date : 2024-09-05 Simar S. Bajaj, Ahmed M. Ahmed, Valerie E. Stone
Diversity, equity and inclusion (DEI) has become a political lightning rod in the USA, with its laudable mission increasingly misinterpreted as a blunt discriminatory tool. Although such critique has been ongoing for decades, it has intensified in academic medicine in recent months, from the resignation of Johns Hopkins’ chief diversity officer over an email on privilege, to efforts within the American
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A global metric of immune health Nat. Med. (IF 58.7) Pub Date : 2024-09-05 Carola G. Vinuesa, Yuke He, Matthew C. Cook
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Niacin, food intake and cardiovascular effects Nat. Med. (IF 58.7) Pub Date : 2024-09-05 John R. Guyton, William E. Boden
arising from M. Ferrell et al. Nature Medicine https://doi.org/10.1038/s41591-023-02793-8 (2024) Ferrell et al.1 report a surprisingly strong association between terminal metabolites of niacin and major adverse cardiovascular events (MACE), amounting to roughly a doubling of MACE risk in the 4th quartile of circulating levels of the 4PY (N1-methyl-4-pyridone-3-carboxamide) metabolite. The results presented
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Opportunities and challenges for patient-reported outcome assessment in multimorbidity research and practice Nat. Med. (IF 58.7) Pub Date : 2024-09-05 Sarah E. Hughes, Nicola E. Anderson, Eleanor Hathaway, Christel McMullan, Benjamin M. A. Hughes, Philip Collis, John Devin Peipert, Shamil Haroon, Melanie Calvert
Multimorbidity, the cooccurrence of two or more chronic health conditions within the same individual, is increasingly prevalent worldwide and is associated with decreased health-related quality of life, increased mortality, and greater healthcare utilization1,2. The clinical care of multimorbidity is complex, arising from potential interactions between conditions, treatment regimens and overlapping
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Hibernation science harnessed to treat obesity and modify metabolism Nat. Med. (IF 58.7) Pub Date : 2024-09-04
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CAR-T and cellular gene therapies are too expensive Nat. Med. (IF 58.7) Pub Date : 2024-09-04 Boro Dropulić
Point-of-care manufacturing and technology transfer can deliver cellular gene therapies at an affordable cost to patients across the world.
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The WHO genomics program of work for equitable implementation of human genomics for global health Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Elena Ambrosino, Ahmad N. Abou Tayoun, Marc Abramowicz, Bin Alwi Zilfalil, Tiffany Boughtwood, Yosr Hamdi, Tim Hubbard, Kazuto Kato, Iscia Lopes-Cendes, Partha Pratim Majumder, Deborah Mascalzoni, Rokhaya Ndiaye, Michèle Ramsay, Gabriela M. Repetto, Vorasuk Shotelersuk, Sherry Taylor, John C. Reeder, Anna Laura Ross
The publication of the first draft of the human genome sequence in 20011 was followed by the advent of high-throughput methodologies, which together have driven the expansion of genomic tools and technologies. These efforts have enabled the sequencing of millions of genomes and expedited the functional and clinical annotation of the human genome. The resulting discovery of thousands of gene–disease
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A time-stratified, case–crossover study of heat exposure and perinatal mortality from 16 hospitals in sub-Saharan Africa Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Claudia Hanson, Jeroen de Bont, Kristi Sidney Annerstedt, Maria del Rosario Alsina, Federica Nobile, Nathalie Roos, Peter Waiswa, Andrea Pembe, Jean-Paul Dossou, Effie Chipeta, Lenka Benova, Hussein Kidanto, Cherie Part, Massimo Stafoggia, Veronique Filippi, Petter Ljungman
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A framework for sharing of clinical and genetic data for precision medicine applications Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Ahmed Elhussein, Ulugbek Baymuradov, Noémie Elhadad, Karthik Natarajan, Gamze Gürsoy
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Advancing global antibiotic research, development and access Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Laura J. V. Piddock, Yewande Alimi, James Anderson, Damiano de Felice, Catrin E. Moore, John-Arne Røttingen, Henry Skinner, Peter Beyer
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Integrating liver endpoints in clinical trials of cardiovascular and kidney disease Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Faiez Zannad, Arun J. Sanyal, Javed Butler, Veronica Miller, Stephen A. Harrison
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Fratricide-resistant CD7-CAR T cells in T-ALL Nat. Med. (IF 58.7) Pub Date : 2024-09-03 Bernice L. Z. Oh, Noriko Shimasaki, Elaine Coustan-Smith, Esther Chan, Limei Poon, Shawn H. R. Lee, Frances Yeap, Lip Kun Tan, Louis Y. A. Chai, Nina Le Bert, Nicole Tan, Antonio Bertoletti, Siew Peng Chen, Francesca Del Bufalo, Marco Becilli, Franco Locatelli, Allen E. J. Yeoh, Dario Campana
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Sustained HIV remission after allogeneic hematopoietic stem cell transplantation with wild-type CCR5 donor cells Nat. Med. (IF 58.7) Pub Date : 2024-09-02 Asier Sáez-Cirión, Anne-Claire Mamez, Véronique Avettand-Fenoel, Mitja Nabergoj, Caroline Passaes, Paul Thoueille, Laurent Decosterd, Maxime Hentzien, Federico Perdomo-Celis, Maria Salgado, Monique Nijhuis, Adeline Mélard, Elise Gardiennet, Valérie Lorin, Valérie Monceaux, Anaïs Chapel, Maël Gourvès, Marine Lechartier, Hugo Mouquet, Annemarie Wensing, Javier Martinez-Picado, Sabine Yerly, Mathieu Rougemont
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Artificial intelligence guided screening for cardiomyopathies in an obstetric population: a pragmatic randomized clinical trial Nat. Med. (IF 58.7) Pub Date : 2024-09-02 Demilade A. Adedinsewo, Andrea Carolina Morales-Lara, Bosede B. Afolabi, Oyewole A. Kushimo, Amam C. Mbakwem, Kehinde F. Ibiyemi, James Ayodele Ogunmodede, Hadijat Olaide Raji, Sadiq H. Ringim, Abdullahi A. Habib, Sabiu M. Hamza, Okechukwu S. Ogah, Gbolahan Obajimi, Olugbenga Oluseun Saanu, Olusoji E. Jagun, Francisca O. Inofomoh, Temitope Adeolu, Kamilu M. Karaye, Sule A. Gaya, Isiaka Alfa, Cynthia
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Senolytics target cellular senescence — but can they slow aging? Nat. Med. (IF 58.7) Pub Date : 2024-09-02
Senolytics can prevent and treat age-related diseases in mice, but data in humans are lacking — for now.
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Finerenone in Heart Failure and Chronic Kidney Disease with Type 2 Diabetes: the FINE-HEART pooled analysis of cardiovascular, kidney, and mortality outcomes Nat. Med. (IF 58.7) Pub Date : 2024-09-01 Muthiah Vaduganathan, Gerasimos Filippatos, Brian L. Claggett, Akshay S. Desai, Pardeep S. Jhund, Alasdair Henderson, Meike Brinker, Peter Kolkhof, Patrick Schloemer, James Lay-Flurrie, Prabhakar Viswanathan, Carolyn S. P. Lam, Michele Senni, Sanjiv J. Shah, Adriaan A. Voors, Faiez Zannad, Peter Rossing, Luis M. Ruilope, Stefan D. Anker, Bertram Pitt, Rajiv Agarwal, John J. V. McMurray, Scott D. Solomon
Cardiovascular-kidney-metabolic syndrome is an emerging entity that connects cardiovascular diseases, chronic kidney disease, and diabetes. The non-steroidal mineralocorticoid receptor antagonist, finerenone, has been studied in three prospective randomized clinical trials of patients with cardio-kidney-metabolic syndrome: FIDELIO-DKD, FIGARO-DKD, and FINEARTS-HF. In light of the strong epidemiological
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Digital consults in heart failure care: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2024-08-31 Jelle P. Man, Maarten A. C. Koole, Paola G. Meregalli, M. Louis Handoko, Susan Stienen, Frederik J. de Lange, Michiel M. Winter, Marlies P. Schijven, Wouter E. M. Kok, Dorianne I. Kuipers, Pim van der Harst, Folkert W. Asselbergs, Aeilko H. Zwinderman, Marcel G. W. Dijkgraaf, Steven A. J. Chamuleau, Mark J. Schuuring
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Unidirectional association of clonal hematopoiesis with atherosclerosis development Nat. Med. (IF 58.7) Pub Date : 2024-08-30 Miriam Díez-Díez, Beatriz L. Ramos-Neble, Jorge de la Barrera, J. C. Silla-Castro, Ana Quintas, Enrique Vázquez, M. Ascensión Rey-Martín, Benedetta Izzi, Lucía Sánchez-García, Inés García-Lunar, Guiomar Mendieta, Virginia Mass, Nuria Gómez-López, Cristina Espadas, Gema González, Antonio J. Quesada, Ana García-Álvarez, Antonio Fernández-Ortiz, Enrique Lara-Pezzi, Ana Dopazo, Fátima Sánchez-Cabo, Borja
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Tracking non-relapse mortality after CAR T cell therapy Nat. Med. (IF 58.7) Pub Date : 2024-08-30 Viktoria Blumenberg, Marcela V. Maus
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Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk Nat. Med. (IF 58.7) Pub Date : 2024-08-30
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Could video games be good for your health? Nat. Med. (IF 58.7) Pub Date : 2024-08-30
A large causal analysis based on a natural experiment suggests that gaming improves psychological well-being, but these benefits tapered off after more than 3 hours of gaming per day.
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Electronic nudges for sustained influenza vaccination uptake in older adults: the nationwide randomized NUDGE-FLU-2 trial Nat. Med. (IF 58.7) Pub Date : 2024-08-30 Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S. Bhatt, Daniel Modin, Safia Chatur, Brian L. Claggett, Kira Hyldekær Janstrup, Carsten Schade Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Lars Køber, Scott D. Solomon, Pradeesh Sivapalan, Jens Ulrik Stæhr Jensen, Cyril Jean-Marie Martel, Tyra Grove Krause, Tor Biering-Sørensen
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MIDAS: a new platform for quality-graded health data for AI-enabled healthcare in India Nat. Med. (IF 58.7) Pub Date : 2024-08-29 Dibyajyoti Maity, Rohit Satish, Dushyantsinh Anupsinh Jadeja, Raghu Dharmaraju, Vijay Chandru, Rajesh Sundaresan, Harpreet Singh, Debnath Pal
India is actively promoting a digital health ecosystem to support its quest for universal healthcare. Quality-graded health data can provide exceptional decision-making support in this endeavor. The biggest hurdle to developing artificial intelligence (AI)-enabled healthcare technologies in India is the availability of high-quality annotated data for South Asians, especially Indians, that can be used
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Simplifying obstetric sonography with AI Nat. Med. (IF 58.7) Pub Date : 2024-08-29
Researchers developed an AI-enabled, battery-operated tool that can be operated by clinicians with no sonography experience — and that measures gestational age as accurately as high-specification ultrasound.
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Author Correction: Androgen receptor pathway inhibitors and taxanes in metastatic prostate cancer: an outcome-adaptive randomized platform trial Nat. Med. (IF 58.7) Pub Date : 2024-08-28 Bram De Laere, Alessio Crippa, Andrea Discacciati, Berit Larsson, Maria Persson, Susanne Johansson, Sanne D’hondt, Rebecka Bergström, Venkatesh Chellappa, Markus Mayrhofer, Mahsan Banijamali, Anastasijia Kotsalaynen, Céline Schelstraete, Jan Pieter Vanwelkenhuyzen, Marie Hjälm-Eriksson, Linn Pettersson, Anders Ullén, Nicolaas Lumen, Gunilla Enblad, Camilla Thellenberg Karlsson, Elin Jänes, Johan Sandzén
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03204-2, published online 20 August 2024.