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Helmholtz Health task force to strengthen prevention research and its translation globally Nat. Med. (IF 58.7) Pub Date : 2025-04-18
Prevention research aims to understand, mitigate and ultimately avert the onset and progression of disease and the spillover of pathogens. Such research includes the analysis of risk factors and fundamental mechanisms of disease emergence, early detection and screening, stratification into risk groups, and the development and evaluation of preventive interventions. In the face of population aging and
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Association between plausible genetic factors and weight loss from GLP1-RA and bariatric surgery Nat. Med. (IF 58.7) Pub Date : 2025-04-18 Jakob German, Mattia Cordioli, Veronica Tozzo, Sarah Urbut, Kadri Arumäe, Roelof A. J. Smit, Jiwoo Lee, Josephine H. Li, Adrian Janucik, Yi Ding, Akintunde Akinkuolie, Henrike O. Heyne, Andrea Eoli, Chadi Saad, Yasser Al-Sarraj, Rania Abdel-latif, Shaban Mohammed, Moza Al Hail, Alexandra Barry, Zhe Wang, Tatiana Cajuso, Andrea Corbetta, Pradeep Natarajan, Samuli Ripatti, Anthony Philippakis, Lukasz
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BCMA-CAR T-cells in a patient with relapsing idiopathic inflammatory myositis after CD19-CAR T-cells Nat. Med. (IF 58.7) Pub Date : 2025-04-17 Fabian Müller, Andreas Wirsching, Melanie Hagen, Simon Völkl, Carlo Tur, Maria Gabriella Raimondo, Jule Taubmann, Laura Bucci, Liang Zhang, Sascha Kretschmann, Michael Aigner, Markus Eckstein, Silvia Spörl, Soraya Kharboutli, Sebastian Böltz, Armin Atzinger, Luis Munoz, Georg Schett, Andreas Mackensen, Ricardo Grieshaber-Bouyer
CD19 chimeric antigen receptor (CD19-CAR) T-cell therapy has been shown to induce stable drug-free remission in patients with refractory autoimmune disease. The management of potential relapses is currently unclear. Here, we report on a 45-year-old woman with treatment-refractory Jo-1-associated anti-synthetase syndrome, who initially achieved disease remission after CD19-CAR T-cell therapy but then
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Using AI to screen for opioid use disorder Nat. Med. (IF 58.7) Pub Date : 2025-04-17 Louisa Picco, Suzanne Nielsen
An AI-driven screener for opioid use disorder in hospital settings could increase referrals to addiction services and improve patient outcomes, but it is crucial that treatment is accessible and that unintended harms such as stigma are avoided.
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Anti-amyloid could help prevent genetic form of Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2025-04-17
Despite a negative primary outcome, a trial of gantenerumab showed a clinically meaningful slowing of disease onset in asymptomatic people who were treated for the longest duration.
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Author Correction: Mpox poses an ever-increasing epidemic and pandemic risk Nat. Med. (IF 58.7) Pub Date : 2025-04-16 Carlos Maluquer de Motes, David O. Ulaeto
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03589-8, published online 1 April 2025.
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Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-16 Lindsay B. Kilburn, Dong-Anh Khuong-Quang, Jordan R. Hansford, Daniel Landi, Jasper van der Lugt, Sarah E. S. Leary, Pablo Hernáiz Driever, Simon Bailey, Sébastien Perreault, Geoffrey McCowage, Angela J. Waanders, David S. Ziegler, Olaf Witt, Patricia A. Baxter, Hyoung Jin Kang, Timothy E. Hassall, Jung Woo Han, Darren Hargrave, Andrea T. Franson, Michal Yalon Oren, Helen Toledano, Valérie Larouche
Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02668-y, published online 17 November 2023.
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Meta-prediction of coronary artery disease risk Nat. Med. (IF 58.7) Pub Date : 2025-04-16 Shang-Fu Chen, Sang Eun Lee, Hossein Javedani Sadaei, Jun-Bean Park, Ahmed Khattab, Jei-Fu Chen, Corneliu Henegar, Nathan E. Wineinger, Evan D. Muse, Ali Torkamani
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Publisher Correction: Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-15 Frank J. Lowery, Stephanie L. Goff, Billel Gasmi, Maria R. Parkhurst, Nivedita M. Ratnam, Hyunmi K. Halas, Thomas E. Shelton, Michelle M. Langhan, Aarushi Bhasin, Aaron J. Dinerman, Victoria Dulemba, Ian S. Goldlust, Alexandra M. Gustafson, Abraham A. Hakim, Kyle J. Hitscherich, Lisa M. Kenney, Lior Levy, Juliette G. Rault-Wang, Alakesh Bera, Satyajit Ray, Courtney D. Seavey, Chuong D. Hoang, Jonathan
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03627-5, published online 1 April 2025.
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Can AI-powered brain–computer interfaces boost human intelligence? Nat. Med. (IF 58.7) Pub Date : 2025-04-15
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Author Correction: LILRB3 genetic variation is associated with kidney transplant failure in African American recipients Nat. Med. (IF 58.7) Pub Date : 2025-04-15 Zeguo Sun, Zhengzi Yi, Chengguo Wei, Wenlin Wang, Tianyuan Ren, Paolo Cravedi, Fasika Tedla, Stephen C. Ward, Evren Azeloglu, Daniel R. Schrider, Yun Li, Atlas Khan, Francesca Zanoni, Jia Fu, Sumaria Ali, Shun Liu, Deguang Liang, Tong Liu, Hong Li, Caixia Xi, Thi Ha Vy, Gohar Mosoyan, Quan Sun, Ashwani Kumar, Zhongyang Zhang, Samira Farouk, Kirk Campell, Jordi Ochando, Kyung Lee, Steve Coca, Jenny
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03568-z, published online 10 March 2025.
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Reprogramming the tumor immune microenvironment to treat glioblastoma Nat. Med. (IF 58.7) Pub Date : 2025-04-15
Johanna Joyce describes how disrupting tumor-associated macrophages showed the importance of the tumor microenvironment in treating cancer.
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CONSORT 2025 statement: updated guideline for reporting randomized trials Nat. Med. (IF 58.7) Pub Date : 2025-04-15 Sally Hopewell, An-Wen Chan, Gary S. Collins, Asbjørn Hróbjartsson, David Moher, Kenneth F. Schulz, Ruth Tunn, Rakesh Aggarwal, Michael Berkwits, Jesse A. Berlin, Nita Bhandari, Nancy J. Butcher, Marion K. Campbell, Runcie C. W. Chidebe, Diana Elbourne, Andrew Farmer, Dean A. Fergusson, Robert M. Golub, Steven N. Goodman, Tammy C. Hoffmann, John P. A. Ioannidis, Brennan C. Kahan, Rachel L. Knowles
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Gene-edited pig liver successfully transplanted into human Nat. Med. (IF 58.7) Pub Date : 2025-04-14
The first pig liver to be transplanted into a human (in this case, a brain-dead recipient) showed sustained function without rejection — marking another step toward xenotransplantation as a viable approach to addressing the organ-shortage crisis.
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A cell atlas of human endometrium reveals key molecular and cellular alterations in PCOS Nat. Med. (IF 58.7) Pub Date : 2025-04-11
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Impact of the ONCOBIOME network in cancer microbiome research Nat. Med. (IF 58.7) Pub Date : 2025-04-11 Laurence Zitvogel, Lisa Derosa, Bertrand Routy, Sibylle Loibl, Lucie Heinzerling, I. Jolanda M. de Vries, Lars Engstrand, Nicola Segata, Guido Kroemer
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Clinical translation of microbiome research Nat. Med. (IF 58.7) Pub Date : 2025-04-11 Jack A. Gilbert, Meghan B. Azad, Fredrik Bäckhed, Martin J. Blaser, Mariana Byndloss, Charles Y. Chiu, Hiutung Chu, Lara R. Dugas, Eran Elinav, Sean M. Gibbons, Katharine E. Gilbert, Matthew R. Henn, Suzanne L. Ishaq, Ruth E. Ley, Susan V. Lynch, Eran Segal, Tim D. Spector, Philip Strandwitz, Jotham Suez, Carolina Tropini, Katrine Whiteson, Rob Knight
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Sacituzumab tirumotecan in previously treated metastatic triple-negative breast cancer: a randomized phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-11 Yongmei Yin, Ying Fan, Quchang Ouyang, Lihua Song, Xiaojia Wang, Wei Li, Man Li, Xi Yan, Shusen Wang, Tao Sun, Yuee Teng, Xianjun Tang, Zhongsheng Tong, Zhengkui Sun, Junyou Ge, Xiaoping Jin, Yina Diao, Gesha Liu, Binghe Xu
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IVF versus ICSI in patients without severe male factor infertility: a randomized clinical trial Nat. Med. (IF 58.7) Pub Date : 2025-04-11 Sine Berntsen, Anne Zedeler, Bugge Nøhr, Morten Rønn Petersen, Marie Louise Grøndahl, Lars Franch Andersen, Kristine Løssl, Ellen Løkkegaard, Anne Lis Englund, Anette Vestergaard Gabrielsen, Lisbeth Prætorius, Ida Behrendt-Møller, Lea Langhoff Thuesen, Kilian Vomstein, Mette Petri Lauritsen, Aleksandra Ivanoska Trajcevski, Dea Frøding Skipper, David Westergaard, Anja Pinborg, Henriette Svarre Nielsen
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Author Correction: Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults Nat. Med. (IF 58.7) Pub Date : 2025-04-11 Magda Bosch de Basea, Isabelle Thierry-Chef, Richard Harbron, Michael Hauptmann, Graham Byrnes, Maria-Odile Bernier, Lucian Le Cornet, Jérémie Dabin, Gilles Ferro, Tore S. Istad, Andreas Jahnen, Choonsik Lee, Carlo Maccia, Françoise Malchair, Hilde Olerud, Steven L. Simon, Jordi Figuerola, Anna Peiro, Hilde Engels, Christoffer Johansen, Maria Blettner, Magnus Kaijser, Kristina Kjaerheim, Amy Berrington
Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02620-0, published online 9 November 2023.
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Sacituzumab tirumotecan in advanced non-small-cell lung cancer with or without EGFR mutations: phase 1/2 and phase 2 trials Nat. Med. (IF 58.7) Pub Date : 2025-04-10 Shen Zhao, Ying Cheng, Qiming Wang, Xingya Li, Jun Liao, Jordi Rodon, Xiangjiao Meng, Yongzhong Luo, Zhendong Chen, Wei Wang, Tienan Yi, Yongsheng Li, Yongmei Yin, Huiting Xu, Guohua Yu, Yanjun Mi, Yun Fan, Zev A. Wainberg, Xiang Wang, Cuiyun Su, Qitao Yu, Shuzhen Lai, Longhua Sun, Wu Zhuang, Xian Wang, Jiacheng Yang, Yaling Li, Junyou Ge, Jin Li, Li Zhang, Wenfeng Fang
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New approaches to opioid-free pain treatment Nat. Med. (IF 58.7) Pub Date : 2025-04-10
The success of new non-opioid drugs and other treatments for pain offer some relief for sufferers.
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Author Correction: Pay-it-forward incentives for hepatitis virus testing in men who have sex with men: a cluster randomized trial Nat. Med. (IF 58.7) Pub Date : 2025-04-09 Ye Zhang, Jianjun Li, Yewei Xie, Dan Wu, Jason Ong, Gifty Marley, Adeeba Kamarulzaman, Haidong Lu, Fei Zou, Jennifer S. Smith, Joseph D. Tucker, Gengfeng Fu, Weiming Tang
Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02519-w, published online 28 August 2023.
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Author Correction: AI-guided precision parenteral nutrition for neonatal intensive care units Nat. Med. (IF 58.7) Pub Date : 2025-04-09 Thanaphong Phongpreecha, Marc Ghanem, Jonathan D. Reiss, Tomiko T. Oskotsky, Samson J. Mataraso, Davide De Francesco, S. Momsen Reincke, Camilo Espinosa, Philip Chung, Taryn Ng, Jean M. Costello, Jennifer A. Sequoia, Sheila Razdan, Feng Xie, Eloise Berson, Yeasul Kim, David Seong, May Y. Szeto, Faith Myers, Hannah Gu, John Feister, Courtney P. Verscaj, Laura A. Rose, Lucas W. Y. Sin, Boris Oskotsky
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03601-1, published online 25 March 2025.
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Plasma phospho-tau217 for Alzheimer’s disease diagnosis in primary and secondary care using a fully automated platform Nat. Med. (IF 58.7) Pub Date : 2025-04-09 Sebastian Palmqvist, Noëlle Warmenhoven, Federica Anastasi, Andrea Pilotto, Shorena Janelidze, Pontus Tideman, Erik Stomrud, Niklas Mattsson-Carlgren, Ruben Smith, Rik Ossenkoppele, Kübra Tan, Anna Dittrich, Ingmar Skoog, Henrik Zetterberg, Virginia Quaresima, Chiara Tolassi, Kina Höglund, Duilio Brugnoni, Albert Puig-Pijoan, Aida Fernández-Lebrero, José Contador, Alessandro Padovani, Mark Monane,
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Genomic census of invasive nontyphoidal Salmonella infections reveals global and local human-to-human transmission Nat. Med. (IF 58.7) Pub Date : 2025-04-09 Haiyang Zhou, Chenghao Jia, Ping Shen, Chenghu Huang, Lin Teng, Beibei Wu, Zining Wang, Haoqiu Wang, Yonghong Xiao, Stephen Baker, François-Xavier Weill, Yan Li, Min Yue
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Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-09 Martin Wermke, Dejka M. Araurjo, Manik Chatterjee, Apostolia M. Tsimberidou, Tobias A. W. Holderried, Amir A. Jazaeri, Ran Reshef, Carsten Bokemeyer, Winfried Alsdorf, Katrin Wetzko, Peter Brossart, Katrin Aslan, Linus Backert, Sebastian Bunk, Jens Fritsche, Swapna Gulde, Silvana Hengler, Norbert Hilf, Mohammad B. Hossain, Jens Hukelmann, Mamta Kalra, Delfi Krishna, M. Alper Kursunel, Dominik Maurer
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Whole diets, whole health Nat. Med. (IF 58.7) Pub Date : 2025-04-08 Eirini Trichia, Jakub G. Sobiecki, Keren Papier
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A benchmarking crisis in biomedical machine learning Nat. Med. (IF 58.7) Pub Date : 2025-04-08 Faisal Mahmood
A lack of standardized benchmarks is hindering progress and patient benefits
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Inflammation and disrupted hematopoiesis drive clonal dominance in a mouse model of VEXAS syndrome Nat. Med. (IF 58.7) Pub Date : 2025-04-08
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Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes Nat. Med. (IF 58.7) Pub Date : 2025-04-08 Hao Wu, Bomin Lv, Luqian Zhi, Yikai Shao, Xinyan Liu, Matthias Mitteregger, Rima Chakaroun, Valentina Tremaroli, Stanley L. Hazen, Ru Wang, Göran Bergström, Fredrik Bäckhed
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Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial Nat. Med. (IF 58.7) Pub Date : 2025-04-08 Atif Rahman, Abid Malik, Huma Nazir, Ahmed Zaidi, Anum Nisar, Ahmed Waqas, Najia Atif, Naomi Kate Gibbs, Yutian Luo, Siham Sikander, Duolao Wang
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Combating vaccine revisionism Nat. Med. (IF 58.7) Pub Date : 2025-04-07
The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.
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Broad versus limited gene panels to guide treatment in patients with advanced solid tumors: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-04-07 Olivier Trédan, Damien Pouessel, Nicolas Penel, Sylvie Chabaud, Carlos Gomez-Roca, Jean-Pierre Delord, Diane Pannier, Mehdi Brahmi, Michel Fabbro, Marie-Eve Garcia, Delphine Larrieu-Ciron, Isabelle Ray-Coquard, Marie Viala, Antoine Italiano, Diego Tosi, Philippe Cassier, Armelle Dufresne, Valery Attignon, Sandrine Boyault, Isabelle Treilleux, Alain Viari, David Pérol, Jean Yves Blay
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A vaccine chatbot intervention for parents to improve HPV vaccination uptake among middle school girls: a cluster randomized trial Nat. Med. (IF 58.7) Pub Date : 2025-04-07 Zhiyuan Hou, Zhengdong Wu, Zhiqiang Qu, Liubing Gong, Hui Peng, Mark Jit, Heidi J. Larson, Joseph T. Wu, Leesa Lin
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Mechanisms of hematopoietic clonal dominance in VEXAS syndrome Nat. Med. (IF 58.7) Pub Date : 2025-04-07 Raffaella Molteni, Martina Fiumara, Corrado Campochiaro, Roberta Alfieri, Guido Pacini, Eugenia Licari, Alessandro Tomelleri, Elisa Diral, Angelica Varesi, Alessandra Weber, Pamela Quaranta, Luisa Albano, Chiara Gaddoni, Luca Basso-Ricci, Davide Stefanoni, Laura Alessandrini, Sara Degl’Innocenti, Francesca Sanvito, Gregorio Maria Bergonzi, Andrea Annoni, Maddalena Panigada, Eleonora Cantoni, Daniele
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Sociodemographic biases in medical decision making by large language models Nat. Med. (IF 58.7) Pub Date : 2025-04-07 Mahmud Omar, Shelly Soffer, Reem Agbareia, Nicola Luigi Bragazzi, Donald U. Apakama, Carol R. Horowitz, Alexander W. Charney, Robert Freeman, Benjamin Kummer, Benjamin S. Glicksberg, Girish N. Nadkarni, Eyal Klang
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Author Correction: Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry Nat. Med. (IF 58.7) Pub Date : 2025-04-07 Poornima Bhat-Nakshatri, Hongyu Gao, Aditi S. Khatpe, Adedeji K. Adebayo, Patrick C. McGuire, Cihat Erdogan, Duojiao Chen, Guanglong Jiang, Felicia New, Rana German, Lydia Emmert, George Sandusky, Anna Maria Storniolo, Yunlong Liu, Harikrishna Nakshatri
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03011-9, published online 9 August 2024.
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Precision Omics Initiative Sweden (PROMISE) will integrate research with healthcare Nat. Med. (IF 58.7) Pub Date : 2025-04-04 Anders Kämpe, Sanna Gudmundsson, Colum P. Walsh, Kerstin Lindblad-Toh, Åsa Johansson, Anna Clareborn, Adam Ameur, Anders Edsjö, Thoas Fioretos, Hans Ehrencrona, Daniel Eriksson, Tove Fall, Paul W. Franks, Ulf Gyllensten, Margareta Haag, Anna Hagwall, Maria Johansson Soller, Janne Lehtiö, Yi Lu, Patrik K. E. Magnusson, Erik Melén, Beatrice Melin, Karl Michaëlsson, Ann Nordgren, Jessica Nordlund, Lao
Data-driven research and precision ‘-omics’ technologies have immense transformative potential to provide tailored treatment and care, embodying the principles of precision medicine. Sweden is a global leader in adopting genomic tools in healthcare. Still, national research datasets from human cohorts are too fragmented or too small to meet the needs of modern precision ‘-omics’ research. This positions
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Implementation of a national AI technology program on cardiovascular outcomes and the health system Nat. Med. (IF 58.7) Pub Date : 2025-04-04 Timothy A. Fairbairn, Liam Mullen, Edward Nicol, Gregory Y. H. Lip, Matthias Schmitt, Matthew Shaw, Laurence Tidbury, Ian Kemp, Jennifer Crooks, Girvan Burnside, Sumeet Sharma, Anoop Chauhan, Chee Liew, Sawan Waidyanatha, Sri Iyenger, Andrew Beale, Imran Sunderji, John P. Greenwood, Manish Motwani, Anna Reid, Anna Beattie, Justin Carter, Peter Haworth, Nicholas Bellenger, Benjamin Hudson, Jonathan
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Stapokibart for moderate-to-severe seasonal allergic rhinitis: a randomized phase 3 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-04 Yuan Zhang, Jingyun Li, Menglin Wang, Xian Li, Bing Yan, Jixiang Liu, Li Shi, Zhiwei Cao, Yan Feng, Weiwei Liu, Zhendong Xu, Ruixia Ma, Xiaoping Gao, Wen Liu, Jinmei Xue, Xiaoyong Ren, Xuezhong Li, Xicheng Song, Yi Yang, Yusheng Wang, Zhimin Xing, Fang Quan, Jing Pan, Yue Sun, Fengpo Shi, Xiaoqiu Chen, Hongyue Yan, Guoqing Zhao, Bo Chen, Chengshuo Wang, Luo Zhang
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Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-04 Yago Nieto, Pinaki Banerjee, Indreshpal Kaur, Rafet Basar, Ye Li, May Daher, Hind Rafei, Lucila N. Kerbauy, Mecit Kaplan, David Marin, Lori Griffin, Melissa Barnett, Roland Bassett, Nadima Uprety, Rejeena Shrestha, Francia Reyes Silva, Sanjida Islam, Christina Ganesh, Zephanie Borneo, Jeremy Ramdial, Alejandro Ramirez, Chitra Hosing, Amin Alousi, Uday Popat, Muzaffar Qazilbash, Sairah Ahmed, Swaminathan
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Clinical implementation of AI-based screening for risk for opioid use disorder in hospitalized adults Nat. Med. (IF 58.7) Pub Date : 2025-04-03 Majid Afshar, Felice Resnik, Cara Joyce, Madeline Oguss, Dmitriy Dligach, Elizabeth S. Burnside, Anne Gravel Sullivan, Matthew M. Churpek, Brian W. Patterson, Elizabeth Salisbury-Afshar, Frank J. Liao, Cherodeep Goswami, Randy Brown, Marlon P. Mundt
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Author Correction: Improving scientific integrity in Chinese medical institutions with the Hospital Research Integrity Alliance Nat. Med. (IF 58.7) Pub Date : 2025-04-03 Guo Hua
Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03595-w, published online 25 March 2025.
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Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-04-03 Godfrey S. Temba, Tal Pecht, Vesla I. Kullaya, Nadira Vadaq, Mary V. Mosha, Thomas Ulas, Sneha Kanungo, Liesbeth van Emst, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Elias Mafuru, Paolo Lionetti, Musa M. Mhlanga, Andre J. van der Ven, Duccio Cavalieri, Leo A. B. Joosten, Reginald A. Kavishe, Blandina T. Mmbaga, Joachim L. Schultze, Mihai G. Netea, Quirijn de Mast
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Using genetics as a tool to understand female reproductive health better Nat. Med. (IF 58.7) Pub Date : 2025-04-02
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TAILORing AI-guided treatment for atrial fibrillation Nat. Med. (IF 58.7) Pub Date : 2025-04-02 Zak Loring, Jonathan P. Piccini
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Real-time surveillance system for patient deterioration: a pragmatic cluster-randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-04-02 Sarah C. Rossetti, Patricia C. Dykes, Chris Knaplund, Sandy Cho, Jennifer Withall, Graham Lowenthal, David Albers, Rachel Y. Lee, Haomiao Jia, Suzanne Bakken, Min-Jeoung Kang, Frank Y. Chang, Li Zhou, David W. Bates, Temiloluwa Daramola, Fang Liu, Jessica Schwartz-Dillard, Mai Tran, Syed Mohtashim Abbas Bokhari, Jennifer Thate, Kenrick D. Cato
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Gut microbiome evolution from infancy to 8 years of age Nat. Med. (IF 58.7) Pub Date : 2025-04-02 Sanjam S. Sawhney, Robert Thänert, Anna Thänert, Carla Hall-Moore, I. Malick Ndao, Bejan Mahmud, Barbara B. Warner, Phillip I. Tarr, Gautam Dantas
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Mpox poses an ever-increasing epidemic and pandemic risk Nat. Med. (IF 58.7) Pub Date : 2025-04-01 Carlos Maluquer de Motes, David O. Ulaeto
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Neoantigen-specific tumor-infiltrating lymphocytes in gastrointestinal cancers: a phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-01 Frank J. Lowery, Stephanie L. Goff, Billel Gasmi, Maria R. Parkhurst, Nivedita M. Ratnam, Hyunmi K. Halas, Thomas E. Shelton, Michelle M. Langhan, Aarushi Bhasin, Aaron J. Dinerman, Victoria Dulemba, Ian S. Goldlust, Alexandra M. Gustafson, Abraham A. Hakim, Kyle J. Hitscherich, Lisa M. Kenney, Lior Levy, Juliette G. Rault-Wang, Alakesh Bera, Satyajit Ray, Courtney D. Seavey, Chuong D. Hoang, Jonathan
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An inflammatory biomarker signature of response to CAR-T cell therapy in non-Hodgkin lymphoma Nat. Med. (IF 58.7) Pub Date : 2025-04-01 Sandeep S. Raj, Teng Fei, Shalev Fried, Andrew Ip, Joshua A. Fein, Lori A. Leslie, Ana Alarcon Tomas, Doris Leithner, Jonathan U. Peled, Magdalena Corona, Parastoo B. Dahi, Ivetta Danylesko, Zachary Epstein-Peterson, Tyler Funnell, Sergio A. Giralt, Elad Jacoby, Meirav Kedmi, Ivan Landego, Richard J. Lin, Allison Parascondola, Lauren Pascual, Natali Orozco, Jae H. Park, M. Lia Palomba, Gilles Salles
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Harnessing artificial intelligence to transform Alzheimer’s disease research Nat. Med. (IF 58.7) Pub Date : 2025-04-01 Sandrine Andrieu, Randall J. Bateman, Erika Bereczki, Niranjan Bose, Anthony J. Brookes, P. Murali Doraiswamy, Miia Kivipelto, Susan Kohlhaas, Lampros Kourtis, Lefkos T. Middleton, Gregory J. Moore, Jeffrey R. Petrella, Neil Postlethwaite, Ricardo Sainz-Fuertes
Alzheimer’s disease remains one of the most formidable challenges in contemporary medicine, necessitating innovative strategies to expedite the development of effective diagnostics and therapeutics1,2. As leaders spanning academia, industry and healthcare, we recognize the profound potential of artificial intelligence (AI) to surmount crucial obstacles in Alzheimer’s research.
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Author Correction: Bioaccumulation of microplastics in decedent human brains Nat. Med. (IF 58.7) Pub Date : 2025-03-31 Alexander J. Nihart, Marcus A. Garcia, Eliane El Hayek, Rui Liu, Marian Olewine, Josiah D. Kingston, Eliseo F. Castillo, Rama R. Gullapalli, Tamara Howard, Barry Bleske, Justin Scott, Jorge Gonzalez-Estrella, Jessica M. Gross, Michael Spilde, Natalie L. Adolphi, Daniel F. Gallego, Heather S. Jarrell, Gabrielle Dvorscak, Maria E. Zuluaga-Ruiz, Andrew B. West, Matthew J. Campen
Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03453-1, published online 3 February 2025.
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A new paradigm for immunotherapy in glioblastoma Nat. Med. (IF 58.7) Pub Date : 2025-03-31 Yosef Ellenbogen, Gelareh Zadeh
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The role of distress in female sexual dysfunction during menopause Nat. Med. (IF 58.7) Pub Date : 2025-03-31 Jiali Duan, John S. Ji, Rong Chen, Martha Hickey, Lan Zhu
Female sexual dysfunction (FSD) has historically received less attention than male sexual dysfunction, in terms of research, diagnosis and treatment, for various reasons, including culturally specific societal stigma, lack of awareness and diagnostic complexities. Sex-hormone insufficiency has long been considered a primary cause of FSD1, particularly during menopause. Menopause marks the end of reproductive
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A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease Nat. Med. (IF 58.7) Pub Date : 2025-03-31 Hamilton Se-Hwee Oh, Deniz Yagmur Urey, Linda Karlsson, Zeyu Zhu, Yuanyuan Shen, Amelia Farinas, Jigyasha Timsina, Michael R. Duggan, Jingsha Chen, Ian H. Guldner, Nader Morshed, Chengran Yang, Daniel Western, Muhammad Ali, Yann Le Guen, Alexandra Trelle, Sanna-Kaisa Herukka, Tuomas Rauramaa, Mikko Hiltunen, Anssi Lipponen, Antti J. Luikku, Kathleen L. Poston, Elizabeth Mormino, Anthony D. Wagner,