Prevention research aims to understand, mitigate and ultimately avert the onset and progression of disease and the spillover of pathogens. Such research includes the analysis of risk factors and fundamental mechanisms of disease emergence, early detection and screening, stratification into risk groups, and the development and evaluation of preventive interventions. In the face of population aging and

CD19 chimeric antigen receptor (CD19-CAR) T-cell therapy has been shown to induce stable drug-free remission in patients with refractory autoimmune disease. The management of potential relapses is currently unclear. Here, we report on a 45-year-old woman with treatment-refractory Jo-1-associated anti-synthetase syndrome, who initially achieved disease remission after CD19-CAR T-cell therapy but then

An AI-driven screener for opioid use disorder in hospital settings could increase referrals to addiction services and improve patient outcomes, but it is crucial that treatment is accessible and that unintended harms such as stigma are avoided.

Despite a negative primary outcome, a trial of gantenerumab showed a clinically meaningful slowing of disease onset in asymptomatic people who were treated for the longest duration.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03589-8, published online 1 April 2025.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02668-y, published online 17 November 2023.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03627-5, published online 1 April 2025.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03568-z, published online 10 March 2025.

Johanna Joyce describes how disrupting tumor-associated macrophages showed the importance of the tumor microenvironment in treating cancer.

The first pig liver to be transplanted into a human (in this case, a brain-dead recipient) showed sustained function without rejection — marking another step toward xenotransplantation as a viable approach to addressing the organ-shortage crisis.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02620-0, published online 9 November 2023.

The success of new non-opioid drugs and other treatments for pain offer some relief for sufferers.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-023-02519-w, published online 28 August 2023.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03601-1, published online 25 March 2025.

A lack of standardized benchmarks is hindering progress and patient benefits

The scientific community must take a strong and active stand against vaccine revisionism — the false narrative that there is insufficient evidence to support the safety and efficacy of vaccines.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03011-9, published online 9 August 2024.

Data-driven research and precision ‘-omics’ technologies have immense transformative potential to provide tailored treatment and care, embodying the principles of precision medicine. Sweden is a global leader in adopting genomic tools in healthcare. Still, national research datasets from human cohorts are too fragmented or too small to meet the needs of modern precision ‘-omics’ research. This positions

Correction to: Nature Medicine https://doi.org/10.1038/s41591-025-03595-w, published online 25 March 2025.

Alzheimer’s disease remains one of the most formidable challenges in contemporary medicine, necessitating innovative strategies to expedite the development of effective diagnostics and therapeutics1,2. As leaders spanning academia, industry and healthcare, we recognize the profound potential of artificial intelligence (AI) to surmount crucial obstacles in Alzheimer’s research.

Correction to: Nature Medicine https://doi.org/10.1038/s41591-024-03453-1, published online 3 February 2025.

Female sexual dysfunction (FSD) has historically received less attention than male sexual dysfunction, in terms of research, diagnosis and treatment, for various reasons, including culturally specific societal stigma, lack of awareness and diagnostic complexities. Sex-hormone insufficiency has long been considered a primary cause of FSD1, particularly during menopause. Menopause marks the end of reproductive