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Broad-Acting Therapeutic Effects of miR-29b-Chitosan on Hypertension and Diabetic Complications Mol. Ther. (IF 12.91) Pub Date : 2022-08-13 David M. Jensen, Peng Han, Lingegowda S. Mangala, Gabriel Lopez-Berestein, Anil K. Sood, Jing Liu, Alison J. Kriegel, Kristie Usa, Michael E. Widlansky, Mingyu Liang
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CRISPR base editing of cis-regulatory elements enables the perturbation of neurodegeneration-linked genes Mol. Ther. (IF 12.91) Pub Date : 2022-08-13 Colin K.W. Lim, Tristan X. McCallister, Christian Saporito-Magriña, Garrett D. McPheron, Ramya Krishnan, M. Alejandra Zeballos C, Jackson E. Powell, Lindsay V. Clark, Pablo Perez-Pinera, Thomas Gaj
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DDX5 mRNA-targeting Antisense Oligonucleotide as a new promising therapeutic in combating Castration-Resistant Prostate Cancer Mol. Ther. (IF 12.91) Pub Date : 2022-08-13 Thi Khanh Le, Chaïma Cherif, Kenneth Omabe, Clément Paris, Francois Lannes, Stéphane Audebert, Emilie Baudelet, Mourad Hamimed, Dominique Barbolosi, Pascal Finetti, Cyril Bastide, Ladan Fazli, Martin Gleave, François Bertucci, David Taïeb, Palma Rocchi
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Targeting N7-Methylguanosine tRNA modification blocks hepatocellular carcinoma metastasis after insufficient radiofrequency ablation Mol. Ther. (IF 12.91) Pub Date : 2022-08-13 Shenghua Zhu, Yifan Wu, Xinyue Zhang, Sui Peng, Han Xiao, Shuling Chen, Lixia Xu, Tianhong Su, Ming Kuang
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Knockdown of MicroRNA Let-7a Improves the Functionality of Bone Marrow-Derived Mesenchymal Stem Cells in Immunotherapy Mol. Ther. (IF 12.91) Pub Date : 2022-08-11 Yang Yu, Li Liao, Bingyi Shao, Xiaoxia Su, Yi Shuai, Han Wang, Fengqing Shang, Zhifei Zhou, Deqin Yang, Yan Jin
Abstract not available
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Modular capsid decoration boosts adenovirus vaccine-induced humoral immunity against SARS-CoV-2 Mol. Ther. (IF 12.91) Pub Date : 2022-08-10 Matthew D.J. Dicks, Louisa M. Rose, Rebecca A. Russell, Lesley A.H. Bowman, Carl Graham, Jose M. Jimenez-Guardeño, Katie J. Doores, Michael H. Malim, Simon J. Draper, Mark Howarth, Sumi Biswas
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Long-term safety of MRI-guided administration of AAV2-GDNF and gadoteridol in the putamen of patients with Parkinson's disease Mol. Ther. (IF 12.91) Pub Date : 2022-08-10 Matthew T. Rocco, Asad S. Akhter, Debra J. Ehrlich, Gretchen C. Scott, Codrin Lungu, Vikas Munjal, Anthony Aquino, Russell R. Lonser, Massimo S. Fiandaca, Mark Hallett, John D. Heiss, Krystof S. Bankiewicz
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Development of 5-FU-modified tumor suppressor microRNAs as a platform for novel microRNA-based cancer therapeutics Mol. Ther. (IF 12.91) Pub Date : 2022-08-06 John G. Yuen, Andrew Fesler, Ga-Ram Hwang, Lan-Bo Chen, Jingfang Ju
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Molecular Therapy’s growing impact Mol. Ther. (IF 12.91) Pub Date : 2022-08-02 Roland W. Herzog, Robert M. Frederickson
Abstract not available
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Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses Mol. Ther. (IF 12.91) Pub Date : 2022-08-02 Kapil Bahl, Joe J. Senn, Olga Yuzhakov, Alex Bulychev, Luis A. Brito, Kimberly J. Hassett, Michael E. Laska, Mike Smith, Örn Almarsson, James Thompson, Amilcar (Mick) Ribeiro, Mike Watson, Tal Zaks, Giuseppe Ciaramella
Abstract not available
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Radiation enhances the efficacy of EGFR-targeted CAR-T cells against triple-negative breast cancer by activating NF-κB/Icam1 signaling Mol. Ther. (IF 12.91) Pub Date : 2022-08-04 Min zhou, Muhua Chen, Bizhi Shi, Shengmeng Di, Ruixin Sun, Hua Jiang, Zonghai Li
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Title: BET Inhibition Triggers Anti-tumor Immunity by Enhancing MHC Class I Expression in Head and Neck Squamous Cell Carcinoma Mol. Ther. (IF 12.91) Pub Date : 2022-08-03 Ming Zhang, Ganping Wang, Zhikun Ma, Gan Xiong, Wenjin Wang, Zhengxian Huang, Yuehan Wan, Xiuyun Xu, Rosalie G. Hoyle, Chen Yi, Jinsong Hou, Xiqiang Liu, Demeng Chen, Jiong Li, Cheng Wang
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The m6A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis Mol. Ther. (IF 12.91) Pub Date : 2022-08-02 Yanli Li, Xinmei Kang, Zhuowei Zhou, Lijie Pan, Huaxin Chen, Xiaoqi Liang, Jiajie Chu, Shuai Dong, Chang Liu, Shanshan Yu, Dan Tu, Yiwang Zhang, Mian Ge, Wenjie Chen, Yan Xu, Qi Zhang
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Recent advances in targeted delivery of non-coding RNA-based therapeutics for atherosclerosis Mol. Ther. (IF 12.91) Pub Date : 2022-08-01 Xiaoxin Li, Hongzhao Qi, Weigang Cui, Zhibin Wang, Xiuxiu Fu, Tianxiang Li, Huibo Ma, Yanyan Yang, Tao Yu
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Macrophages as a therapeutic target to promote diabetic wound healing Mol. Ther. (IF 12.91) Pub Date : 2022-08-02 Maryam Sharifiaghdam, Elnaz Shaabani, Reza Faridi-Majidi, Stefaan C. De Smedt, Kevin Braeckmans, Juan C. Fraire
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Dual role of deubiquitinating enzyme USP19 regulates mitotic progression and tumorigenesis by stabilizing survivin Mol. Ther. (IF 12.91) Pub Date : 2022-08-01 Arun Pandian Chandrasekaran, Apoorvi Tyagi, Naresh Poondla, Neha Sarodaya, Janardhan Keshav Karapurkar, Kamini Kaushal, Chang-Hwan Park, Seok-Ho Hong, Kye-Seong Kim, Suresh Ramakrishna
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Moving targets: COVID-19 vaccine efficacy against Omicron subvariants Mol. Ther. (IF 12.91) Pub Date : 2022-07-31 Maria Karolaynne da Silva, Umberto Laino Fulco, Edilson Dantas da Silva Júnior, Jonas Ivan Nobre Oliveira
Abstract not available
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Mmu-LncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p /HtrA3 signaling axis Mol. Ther. (IF 12.91) Pub Date : 2022-07-21 Jian Pan, Yuxin Xie, Huiling Li, Xiaozhou Li, Junxiang Chen, Xiangfeng Liu, Jun Zhou, Xianming Tang, Zhibiao He, Zhenyu Peng, Hongliang Zhang, Yijian Li, Xudong Xiang, Yunchang Yuan, Dongshan Zhang
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Engineered bispecific antibodies targeting the interleukin-6 and -8 receptors potently inhibit cancer cell migration and tumor metastasis Mol. Ther. (IF 12.91) Pub Date : 2022-07-16 Huilin Yang, Michelle N. Karl, Wentao Wang, Bartholomew Starich, Haotian Tan, Ashley Kiemen, Alexandra B. Pucsek, Yun-Huai Kuo, Gabriella C. Russo, Tim Pan, Elizabeth M. Jaffee, Elana J. Fertig, Denis Wirtz, Jamie B. Spangler
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mRNA-LNP vaccines tuned for systemic immunization induce strong antitumor immunity by engaging splenic immune cells Mol. Ther. (IF 12.91) Pub Date : 2022-07-12 Sanne Bevers, Sander A.A. Kooijmans, Elien Van de Velde, Martijn J.W. Evers, Sofie Seghers, Jerney J.J.M. Gitz-Francois, Nicky C.H. van Kronenburg, Marcel H.A.M. Fens, Enrico Mastrobattista, Lucie Hassler, Helena Sork, Taavi Lehto, Kariem E. Ahmed, Samir El Andaloussi, Katja Fiedler, Karine Breckpot, Michael Maes, Diane Van Hoorick, Stefaan De Koker
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EBAG9-silencing exerts an immune checkpoint function without aggravating adverse effects Mol. Ther. (IF 12.91) Pub Date : 2022-07-12 Anthea Wirges, Mario Bunse, Jara J. Joedicke, Eric Blanc, Venugopal Gudipati, Michael W. Moles, Hiroshi Shiku, Dieter Beule, Johannes B. Huppa, Uta E. Höpken, Armin Rehm
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A precise and efficient adenine base editor Mol. Ther. (IF 12.91) Pub Date : 2022-07-12 Tianxiang Tu, Zongming Song, Xiaoyu Liu, Shengxing Wang, Xiaoxue He, Haitao Xi, Jiahua Wang, Tong Yan, Haoran Chen, Zhenwu Zhang, Xiujuan Lv, Jineng Lv, Xiufeng Huang, Junzhao Zhao, Chao-Po Lin, Caixia Gao, Jinwei Zhang, Feng Gu
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IL-15 Blockade and Rapamycin Rescue Multifactorial Loss of Factor VIII from AAV-Transduced Hepatocytes in Hemophilia A Mice Mol. Ther. (IF 12.91) Pub Date : 2022-07-12 John S.S. Butterfield, Kentaro Yamada, Thais B. Bertolini, Farooq Syed, Sandeep R.P. Kumar, Xin Li, Sreevani Arisa, Annie R. Piñeros, Alejandro Tapia, Christopher A. Rogers, Ning Li, Jyoti Rana, Moanaro Biswas, Cox Terhorst, Randal J. Kaufman, Ype P. de Jong, Roland W. Herzog
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Targeting Glycans for CAR Therapy: the Advent of Sweet CARs Mol. Ther. (IF 12.91) Pub Date : 2022-07-12 Zoe Raglow, Mary Kathryn McKenna, Challice L. Bonifant, Wenjing Wang, Marina Pasca di Magliano, Johannes Stadlmann, Josef M. Penninger, Richard D. Cummings, Malcolm K. Brenner, David M. Markovitz
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AAV capsid engineering identified two novel variants with improved in vivo tropism for cardiomyocytes Mol. Ther. (IF 12.91) Pub Date : 2022-07-09 Laura Rode, Christian Bär, Sonja Groß, Axel Rossi, Nadja Meumann, Janika Viereck, Naisam Abbas, Ke Xiao, Isabelle Riedel, Anika Gietz, Karina Zimmer, Margarete Odenthal, Hildegard Büning, Thomas Thum
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A truncated reverse transcriptase enhances prime editing by split AAV vectors Mol. Ther. (IF 12.91) Pub Date : 2022-07-08 Zongliang Gao, Sujan Ravendran, Nanna S. Mikkelsen, Jakob Haldrup, Huiqiang Cai, Xiangning Ding, Søren R. Paludan, Martin K. Thomsen, Jacob Giehm Mikkelsen, Rasmus O. Bak
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Broadening prime editing toolkits using Pol II-driven engineered pegRNA Mol. Ther. (IF 12.91) Pub Date : 2022-07-06 Shisheng Huang, Zhenwu Zhang, Wanyu Tao, Yao Liu, Xiangyang Li, Xiaolong Wang, Javad Harati, Peng-Yuan Wang, Xingxu Huang, Chao-Po Lin
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Base-edited cynomolgus monkeys mimic core symptoms of STXBP1 encephalopathy Mol. Ther. (IF 12.91) Pub Date : 2022-07-06 Zongyang Lu, Siting He, Jian Jiang, Ling Zhuang, Yan Wang, Guang Yang, Xiaoyu Jiang, Yanhong Nie, Jiqiang Fu, Xiaotong Zhang, Yong Lu, Xinyan Bian, Hung-Chun Chang, Zhiqi Xiong, Xingxu Huang, Zhen Liu, Qiang Sun
Abstract not available
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P2Y12 inhibitor, Clopidogrel inhibits renal fibrosis by blocking macrophage-to-myofibroblast transition Mol. Ther. (IF 12.91) Pub Date : 2022-07-05 Junzhe Chen, Ying Tang, Yu Zhong, Biao Wei, Xiao-Ru Huang, Patrick Ming-Kuen Tang, Anping Xu, Hui-yao Lan
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Tumor necrosis factor alpha delivers exogenous inflammation-related microRNAs to recipient cells with functional targeting capabilities Mol. Ther. (IF 12.91) Pub Date : 2022-07-05 Yuechao Zhao, Tan Zhang, Xuelian Shen, Aixue Huang, Hui Li, Lin Wang, Xuemei Liu, Xuejun Wang, Xiang Song, Shengqi Wang, Jie Dong, Ningsheng Shao
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CircRNA Samd4 induces cardiac repair after myocardial infarction by blocking mitochondria-derived ROS output Mol. Ther. (IF 12.91) Pub Date : 2022-07-04 Hao Zheng, Senlin Huang, Guoquan Wei, Yili Sun, Chuling Li, Xiaoyun Si, Yijin Chen, Zhenquan Tang, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Jianping Bin
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Corneal fibrosis abrogation by a localized AAV mediated inhibitor of differentiation 3 (Id3) gene therapy in rabbit eyes in vivo Mol. Ther. (IF 12.91) Pub Date : 2022-07-02 Suneel Gupta, Michael K. Fink, Duraisamy Kempuraj, Nishant R. Sinha, Lynn M. Martin, Landon M. Keele, Prashant R. Sinha, Elizabeth A. Giuliano, Nathan P. Hesemann, Shyam S. Chaurasia, Rajiv R. Mohan
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Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression Mol. Ther. (IF 12.91) Pub Date : 2022-06-27 Li-Peng Hu, Wuqing Huang, Xu Wang, Chunjie Xu, Wei-Ting Qin, Dongxue Li, Guangang Tian, Qing Li, Yaoqi Zhou, Suyuan Chen, Hui-Zhen Nie, Yujun Hao, Jian Song, Xue-Li Zhang, Jan Sundquist, Kristina Sundquist, Jun Li, Shu-Heng Jiang, Jianguang Ji
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lncRNA Linc00173 modulates glucose metabolism and multidrug chemoresistance inSCLC:Potentialmolecular panel for targeted therapy Mol. Ther. (IF 12.91) Pub Date : 2022-06-27
Abstract not available
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Lipid Nanoparticle Mediated Silencing of Osteogenic Suppressor GNAS Leads to Osteogenic Differentiation of Mesenchymal Stem Cells In Vivo Mol. Ther. (IF 12.91) Pub Date : 2022-06-22 Genc Basha, Andrew G. Cottle, Thavaneetharajah Pretheeban, Karen YT. Chan, Dominik Witzigmann, Robert N. Young, Fabio MV. Rossi, Pieter R. Cullis
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CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma Mol. Ther. (IF 12.91) Pub Date : 2022-06-22 Yuanyuan Ma, Bin Kang, Shaolei Li, Guoyun Xie, Jiwang Bi, Fuqiang Li, Guo An, Bing Liu, Jing Li, Yue Shen, Xun Xu, Huanming Yang, Yue Yang, Ying Gu, Nan Wu
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Eliciting Anti-Cancer Immunity by Genetically Engineered Multifunctional Exosomes Mol. Ther. (IF 12.91) Pub Date : 2022-06-22 Qinqin Cheng, Zhefu Dai, Goar Smbatyan, Alan L. Epstein, Heinz-Josef Lenz, Yong Zhang
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ASGCT 2022 – Bigger than Ever Mol. Ther. (IF 12.91) Pub Date : 2022-06-21 Roland W. Herzog
Abstract not available
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An armed oncolytic virus enhances the efficacy of tumor-infiltrating lymphocyte therapy by converting tumors to artificial antigen presenting cells in situ Mol. Ther. (IF 12.91) Pub Date : 2022-06-17 Kai Ye, Fan Li, Ruikun Wang, Tianyi Cen, Shiyu Liu, Zhuoqian Zhao, Ruonan Li, Lili Xu, Guanmeng Zhang, Zhaoyuan Xu, Li Deng, Lili Li, Wei Wang, Alexey Stepanov, Yajuan Wan, Yu Guo, Yuanke Li, Yuan Wang, Hongkai Zhang
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UNIVERSAL ALLOGENEIC CAR T CELLS ENGINEERED WITH SLEEPING BEAUTY TRANSPOSONS AND CRISPR/CAS9 FOR CANCER IMMUNOTHERAPY Mol. Ther. (IF 12.91) Pub Date : 2022-06-16 Jaitip Tipanee, Ermira Samara-Kuko, Thierry Gevaert, Marinee K. Chuah, Thierry VandenDriessche
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Therapy in Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa Mol. Ther. (IF 12.91) Pub Date : 2022-06-16 Da Meng, Sara D. Ragi, Stephen H. Tsang
Abstract not available
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Addressing the big business of fake science Mol. Ther. (IF 12.91) Pub Date : 2022-06-16 Robert M. Frederickson, Roland W. Herzog
Abstract not available
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Worldwide use of factor IX Padua for hemophilia B gene therapy Mol. Ther. (IF 12.91) Pub Date : 2022-06-14 Benjamin J. Samelson-Jones
Abstract not available
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MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease Mol. Ther. (IF 12.91) Pub Date : 2022-06-09 Marta Esteves, Ricardo Abreu, Hugo Fernandes, Catarina Serra-Almeida, Patrícia A.T. Martins, Marta Barão, Ana Clara Cristóvão, Cláudia Saraiva, Raquel Ferreira, Lino Ferreira, Liliana Bernardino
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Therapeutic base editing and prime editing of COL7A1 mutations in recessive dystrophic epidermolysis bullosa Mol. Ther. (IF 12.91) Pub Date : 2022-06-10 Sung-Ah Hong, Song-Ee Kim, A-Young Lee, Gue-Ho Hwang, Jong Hoon Kim, Hiroaki Iwata, Soo-Chan Kim, Sangsu Bae, Sang Eun Lee
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Evaluating the state of the science for adeno-associated virus integration: An integrated perspective Mol. Ther. (IF 12.91) Pub Date : 2022-06-10 Denise E. Sabatino, Frederic D. Bushman, Randy J. Chandler, Ronald G. Crystal, Beverly L. Davidson, Ricardo Dolmetsch, Kevin C. Eggan, Guangping Gao, Irene Gil-Farina, Mark A. Kay, Douglas M. McCarty, Eugenio Montini, Adora Ndu, Jing Yuan
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CircRNA422 enhanced osteogenic differentiation of bone marrow mesenchymal stem cells during early osseointegration through the SP7/LRP5 axis Mol. Ther. (IF 12.91) Pub Date : 2022-05-31 Ke Yu, Zhiwei Jiang, Xiaoyan Miao, Zhou Yu, Xue Du, Kaichen Lai, Ying Wang, Guoli Yang
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The evolving paradigm of extracellular vesicles in intercellular signaling and delivery of therapeutic RNAs Mol. Ther. (IF 12.91) Pub Date : 2022-05-28 Kevin V. Morris, Kenneth W. Witwer
Abstract not available
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Self-amplifying Loop of NF-κB and Periostin Initiated by PIEZO1 Accelerates Mechano-induced Senescence of Nucleus Pulposus Cells and Intervertebral Disc Degeneration Mol. Ther. (IF 12.91) Pub Date : 2022-05-26 Jinna Wu, Yuyu Chen, Zhiheng Liao, Hengyu Liu, Shun Zhang, Dongmei Zhong, Xianjian Qiu, Taiqiu Chen, Deying Su, Xiaona Ke, Yong Wan, Taifeng Zhou, Peiqiang Su
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Perioperative Arginine Prevents Metastases by Accelerating Natural Killer Cell Recovery After Surgery Mol. Ther. (IF 12.91) Pub Date : 2022-05-26 Leonard Angka, Christiano T. De Souza, Katherine E. Baxter, Sarwat T. Khan, Marisa Market, Andre B. Martel, Lee-Hwa Tai, Michael A. Kennedy, John C. Bell, Rebecca C. Auer
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Neat1 promotes acute kidney injury to chronic kidney disease by facilitating tubular epithelial cells apoptosis via sequestering miR-129-5p Mol. Ther. (IF 12.91) Pub Date : 2022-05-26 Tongtong Ma, Hongwei Li, Hui Liu, Yili Peng, Tong Lin, Zhiya Deng, Nan Jia, Zhongqing Chen, Peng Wang
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Serum extracellular vesicles for delivery of CRISPR-CAS9 ribonucleoproteins to modify the dystrophin gene Mol. Ther. (IF 12.91) Pub Date : 2022-05-26 Nathalie Majeau, Annabelle Fortin-Archambault, Catherine Gérard, Joël Rousseau, Pouiré Yaméogo, Jacques P. Tremblay
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High-throughput characterization of hematopoietic stem cell engraftment after intravenous and intracerebroventricular dosing Mol. Ther. (IF 12.91) Pub Date : 2022-05-25 Robert N. Plasschaert, Mark P. DeAndrade, Fritz Hull, Quoc Nguyen, Tara Peterson, Aimin Yan, Mariana Loperfido, Cristina Baricordi, Luigi Barbarossa, John K. Yoon, Yildirim Dogan, Zeenath Unnisa, Jeffrey W. Schindler, Niek P. van Til, Luca Biasco, Chris Mason
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Base editing the synapse: Modeling a complex neurological disorder in non-human primates Mol. Ther. (IF 12.91) Pub Date : 2022-05-24 Benjamin L. Prosser, Ingo Helbig
Abstract not available
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Retraction Notice to: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing Mol. Ther. (IF 12.91) Pub Date : 2022-05-24 Xiaoxiang Chen, Mu Xu, Xueni Xu, Kaixuan Zeng, Xiangxiang Liu, Li Sun, Bei Pan, Bangshun He, Yuqin Pan, Huiling Sun, Xinyi Xia, Shukui Wang
Abstract not available
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Retraction Notice to: miR-135b Delivered by Gastric Tumor Exosomes Inhibits FOXO1 Expression in Endothelial Cells and Promotes Angiogenesis Mol. Ther. (IF 12.91) Pub Date : 2022-05-24 Ming Bai, Jialu Li, Haiou Yang, Haiyang Zhang, Zhengyang Zhou, Ting Deng, Kegan Zhu, Tao Ning, Qian Fan, Guoguang Ying, Yi Ba
Abstract not available
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Retraction Notice to: CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis Mol. Ther. (IF 12.91) Pub Date : 2022-05-24 Jian Zheng, Xiaobai Liu, PingWang, Yixue Xue, Jun Ma, Chengbin Qu, Yunhui Liu
Abstract not available
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Retraction Notice to: Role of HCP5-miR-139-RUNX1 Feedback Loop in Regulating Malignant Behavior of Glioma Cells Mol. Ther. (IF 12.91) Pub Date : 2022-05-24 Hao Teng, Ping Wang, Yixue Xue, Xiaobai Liu, Jun Ma, Heng Cai, Zhuo Xi, Zhen Li, Yunhui Liu
Abstract not available
更新日期：2022-08-06
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