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Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-28 Annabel J. Critchlow, Sarah E. Alexander, Danielle S. Hiam, Luigi Ferrucci, David Scott, Séverine Lamon
To date, most research investigating the influence of circulating sex hormones on ageing female skeletal muscle has been cross-sectional and focused only on dichotomised young and old, or pre- versus post-menopausal groups. This excludes an important transitional period from high to low circulating oestrogen. Using secondary data from the Baltimore Longitudinal Study of Aging, this study aimed to investigate
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A 10‐Year Longitudinal Study of Muscle Morphology and Performance in Masters Sprinters J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-28 P. W. Hendrickse, B. Hutz, M. T. Korhonen, H. Degens
BackgroundBoth longitudinal and cross‐sectional studies have demonstrated that muscle mass, strength and power are lost with ageing. Although longitudinal studies have shown changes in muscle morphology and function in sedentary, healthy active and endurance‐trained older people, less is known about such age‐related changes in sprint athletes. It has been proposed that active older people may provide
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Mitochondrial Sensitivity to Submaximal [ADP] Following Bed Rest: A Novel Two‐Phase Approach Associated With Fibre Types J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-26 Lucrezia Zuccarelli, Maria De Martino, Antonio Filippi, Alice E. Knapton, Benjamin D. Thackray, Giovanni Baldassarre, Boštjan Šimunič, Rado Pišot, Giuseppe Sirago, Elena Monti, Marco Narici, Miriam Isola, Andrew J. Murray, Giovanna Lippe, Bruno Grassi
BackgroundWe recently demonstrated that following a 10‐day exposure to inactivity/simulated microgravity impairments of oxidative metabolism were located ‘upstream’ of mitochondrial function, as evaluated by maximal ADP‐stimulated mitochondrial respiration (JO2max) determined ex vivo. The aim of this study was to evaluate mitochondrial sensitivity to submaximal [ADP] by an alternative approach aimed
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Myo-Guide: A Machine Learning-Based Web Application for Neuromuscular Disease Diagnosis With MRI J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-24 Jose Verdu-Diaz, Carla Bolano-Díaz, Alejandro Gonzalez-Chamorro, Sam Fitzsimmons, Jodi Warman-Chardon, Goknur Selen Kocak, Debora Mucida-Alvim, Ian C. Smith, John Vissing, Nanna Scharff Poulsen, Sushan Luo, Cristina Domínguez-González, Laura Bermejo-Guerrero, David Gomez-Andres, Javier Sotoca, Anna Pichiecchio, Silvia Nicolosi, Mauro Monforte, Claudia Brogna, Eugenio Mercuri, Jorge Alfredo Bevilacqua
Neuromuscular diseases (NMDs) are rare disorders characterized by progressive muscle fibre loss, leading to replacement by fibrotic and fatty tissue, muscle weakness and disability. Early diagnosis is critical for therapeutic decisions, care planning and genetic counselling. Muscle magnetic resonance imaging (MRI) has emerged as a valuable diagnostic tool by identifying characteristic patterns of muscle
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Issue Information J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-25
No abstract is available for this article.
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The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta‐Analysis J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-25 Konstantinos Prokopidis, Frank Moriarty, Gülistan Bahat, Joseph McLean, David D. Church, Harnish P. Patel
IntroductionSarcopenia is associated with the loss of skeletal muscle function and mass. Nicotinamide precursors, such as nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), have received attention for their potential to improve NAD+ levels and mitigate age‐related sarcopenia in preliminary models, though evidence on their effects in older adults remains inconclusive.MethodsWe searched
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Walking Speed and Risk of Cancer in Two Prospective Cohort Studies J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-25 Jonathan K. L. Mak, Kathryn Choon Beng Tan, Juulia Jylhävä, Sara Hägg, Ching‐Lung Cheung
BackgroundWalking speed is a reliable marker of sarcopenia and a strong predictor of mortality, but its relationship with cancer incidence remains largely unexplored. We aimed to investigate the association between walking speed and the risk of any cancer and five common cancers, including lung, breast, colorectum, prostate, and stomach, and to explore potential mediation by biomarkers of inflammation
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Severe Dietary Energy Restriction for Compensated Cirrhosis Due to Metabolic Dysfunction‐Associated Steatotic Liver Disease: A Randomised Controlled Trial J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-25 Dimitrios A. Koutoukidis, Susan A. Jebb, Jeremy W. Tomlinson, Ferenc E. Mozes, Michael Pavlides, Miriam Lacharie, Francesca Saffioti, Paul Aveyard, Jeremy F. Cobbold
BackgroundCompensated cirrhosis due to metabolic dysfunction‐associated steatotic liver disease (CC‐MASLD) increases morbidity and mortality risk but has no aetiology‐specific treatment. We investigated the safety and efficacy signals of severe energy restriction.MethodsIn this randomised controlled trial, adults with CC‐MASLD and obesity in a tertiary hepatology centre were randomised 2:1 to receive
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Oestrogen Receptor Alpha in Myocyte Maintains Muscle Regeneration in Duchenne Muscular Dystrophy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-24 Xiaofei Huang, Sijia Li, Huna Wang, Lei Zhao, Xihua Li, Shusheng Fan, Wanting Hu, Haowei Tong, Guangyao Guo, Dengqiu Xu, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
BackgroundOestrogen receptor alpha (ERα) plays an important role in maintaining mitochondrial function and regulating metabolism in skeletal muscle. However, its alterations and potential mechanisms in Duchenne muscular dystrophy (DMD) remain incompletely understood. In this study, we demonstrated the protective role of ERα in myocyte for skeletal muscle regeneration in mdx mice and explored the therapeutic
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Loss of popdc3 Impairs Mitochondrial Function and Causes Skeletal Muscle Atrophy and Reduced Swimming Ability in Zebrafish J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-24 Chen‐Chen Sun, Zhang‐Lin Chen, Dong Yang, Jiang‐Ling Xiao, Xiang‐Tao Chen, Xi‐Yang Peng, Xiu‐Shan Wu, Chang‐Fa Tang
BackgroundThe Popeye domain containing 3 (POPDC3) protein is essential for the maintenance of skeletal muscle homeostasis. POPDC3 is a pathogenic variant gene of limb‐girdle muscular dystrophy (LGMD), and its variants lead to LGMDR26. At the animal level, zebrafish larvae with popdc3 mutations develop tail curls and muscle atrophy. However, the mechanism of skeletal muscle atrophy induced by POPDC3
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Transcriptional Intermediary Factor 1γ–Induced Irisin in Skeletal Muscle Attenuates Renal Fibrosis in Diabetic Nephropathy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-24 Jin Hyun Kim, Seunghye Lee, Hani Jang, Sehyun Jung, Myeong Hee Jung, Jeong Won Yun, Haejin Jeon, Hyun‐Jung Kim, Se‐Ho Chang, Eun Ju Lee, Hyo‐Soo Kim
BackgroundTranscriptional intermediary factor 1γ (TIF1γ) is a negative regulator of TGF‐β1 signalling and has been associated with patient survival in renal cell carcinoma. However, its role in diabetes mellitus (DM), particularly in diabetic nephropathy (DN), remains unclear. DN is the leading cause of chronic kidney disease (CKD). We investigated the potential role of TIF1γ in mitigating multiple
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Comment on “Intermittent Hypoxic–Hyperoxic Training During Inpatient Rehabilitation Improves Exercise Capacity and Functional Outcome in Patients With Long Covid: Results of a Controlled Clinical Pilot Trial” by Doehner et al. J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-21
To the Editors of the Journal of Cachexia, Sarcopenia and Muscle It is estimated that around 10% of people infected with COVID-19 continue to struggle with permanent or new symptoms even months after the acute illness [1]. One of the most severe forms of this Long Covid syndrome is known as myalgic encephalitis/chronic fatigue syndrome (ME/CFS). This is a neuroimmunological disease with a prevalence
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Prepregnancy Obesity Reprograms Offspring Skeletal Muscle Fibre Transition Through H3K9me3 J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-21 Yichi Wu, Sujuan Li, Jingyi Zhang, Anran Tian, Xiangyao Wang, Xi Yang, Fucheng Meng, Qing Li, Yuan Gao, Yingying Li, Furong Liang, Minglan Yao, Xiaoping Luo, Cai Zhang
BackgroundMaternal prepregnancy obesity predisposes offspring to obesity and metabolic disorders, yet its impact on skeletal muscle fibre transition remains unclear. Given that skeletal muscle plays a crucial role in systemic metabolism, we investigated how maternal prepregnancy high‐fat diet (HFD) influences muscle fibre composition and metabolic function in offspring.MethodsWe established mouse models
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ExermiR‐129‐3p Enhances Muscle Function by Improving Mitochondrial Activity Through PARP1 Inhibition J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-21 Yeo Jin Shin, Jae Won Yang, Heeyeon Jeong, Joyeong Kim, Bora Lee, Ji‐Won Kim, Seung‐Min Lee, Ju Yeon Kwak, Young Hoon Son, Kap Jung Kim, Yong Ryoul Yang, Chuna Kim, Ki‐Sun Kwon, Kwang‐Pyo Lee
BackgroundPhysical exercise has beneficial effects on various organs, including skeletal muscle. However, not all patients are capable of engaging in exercise to maintain muscle function, which underscores the importance of identifying molecular mechanisms of physical training that could lead to the discovery of exercise‐mimicking molecules.MethodsThis study sought to identify molecular mediators of
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Effectiveness of Mind–Body Exercise in Older Adults With Sarcopenia and Frailty: A Systematic Review and Meta‐Analysis J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-20 Ruihan Wan, Jie Huang, Kangle Wang, Danting Long, Aolong Tao, Jia Huang, Zhizhen Liu
BackgroundMind–body exercise (MBE) has shown promise in mitigating the effects of sarcopenia and frailty in older adults. Nevertheless, its effectiveness in enhancing muscle function and physical performance in this population has not been well established. This study aimed to investigate the effects of MBE on older adults with sarcopenia and frailty, to offer evidence‐based exercise recommendations
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Longitudinal Follow‐Up of Patients With Duchenne Muscular Dystrophy Using Quantitative 23Na and 1H MRI J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-20 Teresa Gerhalter, Benjamin Marty, Lena V. Gast, Frank Roemer, Pierre‐Yves Baudin, Regina Trollmann, Michael Uder, Pierre G. Carlier, Armin M. Nagel
BackgroundQuantitative muscle MRI commonly evaluates disease activity and muscle wasting in Duchenne muscular dystrophy (DMD). Disturbances in ion homeostasis contribute to DMD pathophysiology, but their relationships with disease progression is unclear. 23Na MRI may provide insights into the disease course and treatment response. This longitudinal study assessed whether sodium levels are elevated
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Estimated Glucose Disposal Rate Associated With Risk of Frailty and Likelihood of Reversion J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-17 Dingchun Hou, Shangjun Liu, Yumei Sun, Chang Liu, Xue Shang, Lijun Pei, Gong Chen
BackgroundEstimated glucose disposal rate (eGDR) is a simple and effective measure for insulin resistance, which is associated with higher risk of frailty. We aim to analyse the associations of eGDR with frailty risk and its reversibility.MethodsA population‐based longitudinal study was conducted of 11 670 participants from the China Health and Retirement Longitudinal Study and 19 355 participants
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Estimation of Appendicular Skeletal Muscle Mass in Studies Based on CHARLS May Cause Unreliable Conclusion J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-17 Mingchong Liu, Jiaming Wang, Chensong Yang, Guixin Sun
We write to highlight a potential issue in the estimation of appendicular skeletal muscle mass (ASM) in studies based on the China Health and Retirement Longitudinal Study (CHARLS). In recent years, numerous studies based on the CHARLS database have been published, with a significant number focusing on sarcopenia. A PubMed search reveals that over 94 sarcopenia-related articles based on CHARLS data
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Association of Muscle Radiodensity and Muscle Mass With Thoracic Aortic Calcification Progression in Dialysis Patients J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-17 Xiao‐xu Wang, Jing‐yuan Cao, Yao Wang, Min Li, Shi‐mei Hou, Zhen Zhao, Min Yang, Ping‐ping Ju, Yu‐jia Jiang, Jing‐jie Xiao, Ri‐ring Tang, Hong Liu, Bi‐cheng Liu, Xiao‐liang Zhang, Bin Wang
BackgroundRecent findings have spotlighted sarcopenia as a critical factor exacerbating cardiovascular risk in dialysis patients. However, no studies have investigated the relationship of muscle characteristics with thoracic aortic calcification (TAC). We explored whether skeletal muscle radiodensity (SMD) and skeletal muscle index (SMI) are associated with TAC in dialysis patients.MethodsIn this study
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Comment on “Risk of Sarcopenia Following Long‐Term Statin Use in Community‐Dwelling Middle‐Aged and Older Adults in Japan” by Huang et al. J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-17 Jian Huang
I read with great interest the article ‘Risk of Sarcopenia Following Long-Term Statin Use in Community-Dwelling Middle-Aged and Older Adults in Japan’ by Huang et al. [1]. Although the study addresses a topic of significant clinical relevance, I would like to express concerns regarding two critical methodological aspects that may affect the internal validity of the findings. First, the article reported
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Association of a Combined Body Mass Index and Regional Body Fat Percentage Metric With Fragility Fracture Risk: Evidence from a Large Observational Cohort J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-17 Hamzah Amin, Michelle G. Swainson, Muhammed Aqib Khan, Marwan Bukhari
BackgroundEvidence suggests that high body fat and low muscle mass may increase the risk of fragility fractures. However, current fracture risk models, which largely rely on body mass index (BMI), may not fully capture these compositional factors. We recommend integrating additional body composition variables into fracture risk calculators to improve accuracy. Previously, we described partial body
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Heavy Strength Training in Older Adults: Implications for Health, Disease and Physical Performance J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-17 Tiril Tøien, Ole Kristian Berg, Roberto Modena, Mathias Forsberg Brobakken, Eivind Wang
Older adults typically exhibit reductions in skeletal muscle maximal strength and the ability to produce force rapidly. These reductions are often augmented by concomitant acute and chronic diseases, resulting in attenuated physical performance and higher propensity of falls and injuries. With the proportion of older adults in the population increasing, there is an alarming need for cost‐effective
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Housing Temperature Impacts the Systemic and Tissue‐Specific Molecular Responses to Cancer in Mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-16 Andrea Irazoki, Emma Frank, Tang Cam Phung Pham, Jessica L. Braun, Amy M. Ehrlich, Mark Haid, Fabien Riols, Camilla Hartmann Friis Hansen, Anne‐Sofie Rydal Jørgensen, Nicoline Resen Andersen, Laura Hidalgo‐Corbacho, Roberto Meneses‐Valdes, Mona Sadek Ali, Steffen Henning Raun, Johanne Louise Modvig, Samantha Gallero, Steen Larsen, Zach Gerhart‐Hines, Thomas Elbenhardt Jensen, Maria Rohm, Jonas T. Treebak
BackgroundCancer cachexia, affecting up to 80% of patients with cancer, is characterized by muscle and fat loss with functional decline. Preclinical research seeks to uncover the molecular mechanisms underlying cachexia to identify potential targets. Housing laboratory mice at ambient temperature induces cold stress, triggering thermogenic activity and metabolic adaptations. Yet, the impact of housing
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Comprehensive Evaluation of Frailty and Sarcopenia Markers to Predict Survival in Glioblastoma Patients J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-16 Chao Yang, Chao Ma, Cheng‐Shi Xu, Si‐Rui Li, Chen Li, Ze‐Fen Wang, Zhi‐Qiang Li
BackgroundGlioblastoma (GBM) is the most common primary malignant brain tumour in adults. Patients with GBM are particularly susceptible to moderate‐to‐high frail. Frailty status has been associated with the outcome of many types of cancer, including GBM, although there is still little consensus regarding the specific criteria for assessing frailty status. This study aimed to determine the predictive
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Nutritional Status Predicts Functional Recovery and Adverse Outcomes in Older Adults: A Prospective Cohort Study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-16 Ludiane Alves do Nascimento, Marlon Juliano Romero Aliberti, Natalia Golin, Erika Suíter, Christian Valle Morinaga, Thiago Junqueira Avelino Silva, Pedro Kallas Curiati
BackgroundDespite the high prevalence of malnutrition in acutely ill older patients, nutritional status is rarely assessed in emergency departments (EDs), and the impact of nutritional risk screening on functional recovery is poorly understood. This study aimed to investigate the association between nutritional parameters and a range of outcomes in older patients admitted through the ED.MethodsA prospective
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Association of Appendicular Skeletal Muscle Mass Index and Insulin Resistance With Mortality in Multi‐Nationwide Cohorts J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-15 Shinje Moon, Jong Wook Choi, Jung Hwan Park, Dong Sun Kim, Youhern Ahn, Yeongmin Kim, Sung Hye Kong, Chang‐Myung Oh
BackgroundAlthough sarcopenia and insulin resistance are closely related, there is limited evidence regarding how they interact to influence mortality across different population groups. The purpose of this study was to examine the relationship between skeletal muscle mass and insulin resistance and its impact on mortality and cardiovascular disease risk using large‐scale national data from Korea and
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Comment on ‘Impact of Resistance Training and Chicken Intake on Vascular and Muscle Health in Elderly Women’ by Fujie et al. J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-15 Pincheng Luo, Yihan Shi, Yanxue Lian
We read with great interest the recent article by Fujie et al. [1] published in your esteemed journal. The study provides valuable insights into the effects of moderate-to-high-intensity resistance training (RT) combined with high-protein intake (steamed chicken breast) on arterial stiffness, muscle mass, strength and quality in elderly women. However, we would like to highlight several limitations
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HD6277 Suppresses Muscle Atrophy by Promoting Myogenic Factors and Inhibiting Proteolysis in Aged Mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-15 Joo Won Kim, SukHwan Yun, Min Jeong Park, Eyun Song, Sooyeon Jang, Ahreum Jang, Kyung Mook Choi, Sei Hyun Baik, Hwan‐Jin Hwang, Hye Jin Yoo
BackgroundG protein–coupled receptor 40 (GPR40) acts as a modulator of various physiological functions, including glycaemic lowering, anti‐inflammation and antioxidative stress, in several tissues. However, the role of GPR40 in skeletal muscles remains unclear.MethodsTo investigate the roles of muscle GPR40, C2C12 myoblasts and myotubes were stimulated with palmitate and HD6277, a GPR40 agonist. Muscle
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A Novel Research Paradigm for Sarcopenia of Limb Muscles: Lessons From the Perpetually Working Diaphragm's Anti‐Aging Mechanisms J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-14 Enhui Li, Rui Wang, Yanli Li, Xiang Zan, Shufen Wu, Yiru Yin, Xiaorong Yang, Litian Yin, Yu Zhang, Jianguo Li, Xin Zhao, Ce Zhang
BackgroundSkeletal muscle function and mass continuously decrease during aging. Most studies target limb muscles owing to their direct impact on mobility and falls risk. The diaphragm (DIA), also a type of skeletal muscle with different phenotype, has received less attention. Comparative research of the DIA and limb muscles can reveal their distinct aging characteristics. Critically, the potential
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Ibuprofen, Flurbiprofen or Naproxen Sodium Minimally Influences Musculoskeletal Adaptations to Treadmill Exercise in Rats J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-11 Brandon M. Roberts, Alyssa V. Geddis, Alexandra Ciuciu, Marinaliz Reynoso, Nikhil Mehta, Alyssa N. Varanoske, Alyssa M. Kelley, Maximus C. Leiss, Alexander L. Kolb, Julie M. Hughes, Marshall A. Naimo, Ryan E. Tomlinson, Jeffery S. Staab
BackgroundNon‐steroidal anti‐inflammatory drugs (NSAIDs) may influence musculoskeletal health. The purpose of this study was to compare the effects of three different NSAIDS: naproxen sodium, ibuprofen, flurbiprofen or a placebo on musculoskeletal adaptations in rodents with or without 6 weeks of aerobic exercise.MethodsNine‐week‐old male Wistar rats (n = 80) were randomized to either exercise (EX)
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Impact of Long‐Term Fasting on Skeletal Muscle: Structure, Energy Metabolism and Function Using 31P/1H MRS and MRI J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-11 Antoine Naëgel, Magalie Viallon, Hélène Ratiney, Thu Nguyen, Benjamin Leporq, Djahid Kennouche, Thomas Grenier, Franziska Grundler, Robin Mesnage, Jean‐Michel Guy, Robin Schultze, Françoise Wilhelmi de Toledo, Pierre Croisille
BackgroundFasting shows promise for public health, but concerns about muscle loss hinder its acceptance, particularly among the elderly. We explored the impact of long‐term fasting (12 days, 250 kcal/day) on muscle structure, metabolism and performance.MethodsWe prospectively assessed muscle volume, composition, relaxometry data and lipid metabolism in 32 subjects (16 men; 50% over 50 years old) before
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Comparative Analysis of Primary Sarcopenia and End‐Stage Renal Disease–Related Muscle Wasting Using Multi‐Omics Approaches J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-10 Daiki Setoyama, Dohyun Han, Jingwen Tian, Ho Yeop Lee, Hyun Suk Shin, Ha Thi Nga, Thi Linh Nguyen, Ji Sun Moon, Hyo Ju Jang, Evonne Kim, Seong‐Kyu Choe, Sang Hyeon Ju, Dae Eun Choi, Obin Kwon, Hyon‐Seung Yi
BackgroundAge‐related primary sarcopenia and end‐stage renal disease (ESRD)–related muscle wasting are discrete entities; however, both manifest as a decline in skeletal muscle mass and strength. The etiological pathways differ, with aging factors implicated in sarcopenia and a combination of uremic factors, including haemodialysis, contributing to ESRD‐related muscle wasting. Understanding these molecular
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Resistance and Impact Training During Weight Loss Improves Physical Function and Body Composition in Older Adults With Obesity J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-10 Jakub Mesinovic, Anoohya Gandham, Mavil May Cervo, Paul Jansons, Costas Glavas, Michael Braude, Juan Pena Rodriguez, Barbora De Courten, Ayse Zengin, Belinda R. Beck, Peter R. Ebeling, David Scott
BackgroundWeight loss achieved via energy restriction leads to significant losses in muscle and bone mass, potentially increasing risk for sarcopenia and osteoporosis. High‐intensity resistance and impact training (HiRIT) might attenuate weight loss–induced musculoskeletal declines. Our objective was to compare changes in physical function and body composition in older adults with obesity undertaking
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Longitudinal association between statins and changes in CT‐derived body composition in patients with abdominal aortic aneurysm J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-10 Nicholas A. Bradley, Amy Walter, Chiara Sankey, Alasdair Wilson, Tamim Siddiqui, Campbell S.D. Roxburgh, Donald C. McMillan, Graeme J.K. Guthrie
BackgroundLoss of skeletal muscle mass and systemic inflammation may offer prognostic value in patients with abdominal aortic aneurysm (AAA). The longitudinal progression of abnormal body composition parameters and their determinants is poorly reported. Statins are widely used medications that improve the prognosis of cardiovascular disease and interact with both muscle tissue and systemic inflammation
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A Randomized Controlled ‘REAL‐FITNESS’ Trial to Evaluate Physical Activity in Patients With Newly Diagnosed Multiple Myeloma J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-08 Esther Dreyling, Jan Räder, Mandy‐Deborah Möller, Gabriele Ihorst, Sina Wenger, Antonia Pahl, Jann Arends, Georg Herget, Peter Deibert, Ralph Wäsch, Monika Engelhardt
BackgroundMultiple myeloma (MM) is the second most common haematological malignancy. The predominantly older patients often suffer from comorbidities that impair their quality of life (QoL). Physical activity (PA) can be beneficial for cancer patients, but less evidence exists in MM. This randomized controlled trial (RCT) compared an exercise group with World Health Organization (WHO)–compliant PA
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Activating Striatal Parvalbumin Interneurons to Alleviate Chemotherapy‐Induced Muscle Atrophy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-08 Jun Hu, Jingyuan Liu, Yuqing Yan, Ziyu Shen, Junlong Sun, Yongjun Zheng
BackgroundCisplatin is a widely used chemotherapeutic agent for treating solid tumours. Still, it induces severe side effects, including muscle atrophy. Understanding the mechanisms of cisplatin‐induced muscle loss and exploring potential therapeutic strategies are essential. Parvalbumin (PV) interneurons in the striatum play a crucial role in motor control, and recent studies suggest that their activation
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Multitrajectories of Frailty and Depression With Cognitive Function: Findings From the Health and Retirement Longitudinal Study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-07 Chengxiang Hu, Xiaoyue Sun, Zhirong Li, Yue He, Beibei Han, Zibo Wu, Siyu Liu, Lina Jin
BackgroundLittle is known about the joint associations between trajectories of frailty and depression with cognitive function. This study aims to explore the multitrajectories of frailty and depression and their joint impact on cognition.MethodsA total of 8600 participants from the Health and Retirement Study (HRS) (1996–2018) were analysed using a group‐based trajectory model for 10‐year multitrajectories
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Association of Dietary Choline Intake With Incidence of Frailty: A Nationwide Prospective Cohort Study From China J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-07 Lian‐hong Chen, Jian‐feng Zhong, Ying‐ying Niu, Cheng‐ping Li, Jing Li, Zhi‐quan Diao, Hao‐yu Yan, Miao Xu, Wen‐qi Huang, Zhi‐tong Xu, Chang Su, Dan Liu
BackgroundEmerging evidence suggests that dietary choline is a modifiable nutritional factor linked to various health outcomes. However, most existing studies have focused on isolated health conditions, lacking a comprehensive assessment of overall health status. This study aimed to investigate the association between total dietary choline intake and frailty incidence among Chinese adults, considering
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Osteosarcopenia in Chronic Kidney Disease: An Overlooked Syndrome? J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-07 Lara Caldiroli, Paolo Molinari, Claudia D'Alessandro, Adamasco Cupisti, Carlo Alfieri, Giuseppe Castellano, Simone Vettoretti
BackgroundHealthy ageing relies on maintaining physiological systems, particularly the musculoskeletal system (MKS). After 50, declines in bone density, muscle mass and strength increase the risk of osteoporosis and sarcopenia, leading to frailty, fractures and higher healthcare costs. Osteosarcopenia, combining osteoporosis and sarcopenia, is rising because of the ageing population. Chronic kidney
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Prediction Models for Risk of Cardiorespiratory Morbidity/Mortality and Fracture Among Young Adults With Cerebral Palsy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-05 Daniel G. Whitney, Edward A. Hurvitz
BackgroundThere is a dearth of screening tools for cardiorespiratory disease and fracture risk, such as risk prediction models, for adults with cerebral palsy (CP). There is heterogeneity of pathophysiology related to the severity of CP and aging, such that a suite of risk prediction models may be needed. Differentiating by sarcopenia versus frailty syndromes may be a useful, physiologic‐based framework
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Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine‐Induced Cachexia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-05 Luis Vincens Gand, Chiara Lanzuolo, Mugeng Li, Valentina Rosti, Natalie Weber, Dongchao Lu, Christian Bär, Thomas Thum, Andreas Pich, Theresia Kraft, Mamta Amrute‐Nayak, Arnab Nayak
BackgroundCachexia is a severe form of muscle wasting disorder particularly observed in patients with advanced cancer. The absence of effective strategies to ameliorate cachexia indicates our poor understanding of the mechanisms of cachexia. By employing system‐wide approaches, we investigated molecular mechanisms underlying cancer secreted pro‐inflammatory cytokine‐induced cachexia (CIC).MethodsAs
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Nestin Regulates Autophagy‐Dependent Ferroptosis Mediated Skeletal Muscle Atrophy by Ubiquitinating MAP 1LC3B J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-05 Shunshun Han, Xiyu Zhao, Chunlin Yu, Can Cui, Yao Zhang, Qing Zhu, Mohan Qiu, Chaowu Yang, Huadong Yin
BackgroundProgrammed cell death plays a critical role in skeletal muscle atrophy. Ferroptosis, an iron‐dependent form of programmed cell death driven by lipid peroxidation, has been implicated in various diseases, but its role in skeletal muscle atrophy remains unclear.MethodsFerroptosis in skeletal muscle atrophy was investigated using two models: dexamethasone (Dex)‐induced atrophy (n = 6 independent
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Nuciferine Attenuates Cancer Cachexia‐Induced Muscle Wasting in Mice via HSP90AA1 J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-04 Xueyan An, Lisha Ma, Yulan Bai, Chaoyue Chen, Ji Liu, Awaguli Dawuti, Kewu Zeng, Baoxue Yang, Bo Han, Abudumijiti Abulizi
BackgroundAround 80% of patients with advanced cancer have cancer cachexia (CC), a serious complication for which there are currently no FDA‐approved treatments. Nuciferine (NF) is the main active ingredient of lotus leaf, which has anti‐inflammatory, anti‐tumour and other effects. The purpose of this work was to explore the target and mechanism of NF in preventing cancer cachexia‐induced muscle atrophy
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Low Visceral Adipose Tissue Predicts the Outcome of Neoadjuvant Chemotherapy for Colorectal Liver Metastases: A Multicentre Real‐World Study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-04 Yizhen Chen, Hangdong Jia, Rong Ye, Zhenyuan Zhou, Weijie Chen, Ming Zheng, Yuanyuan Zheng
BackgroundVisceral obesity (VO), associated with excessive visceral adipose tissue (VAT), has been extensively studied in cancer. However, whether low VAT can predict the prognosis of colorectal liver metastases (CRLM) undergoing neoadjuvant chemotherapy (NAC) remains unknown.MethodsThis multicentre real‐world cohort study analysed data from initially resectable CRLM patients who received NAC. The
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Long‐Term Effects of High‐Intensity Aerobic Training on Metabolic Syndrome: An 8‐Year Follow‐Up Randomized Clinical Trial J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-04 Felix Morales‐Palomo, Alfonso Moreno‐Cabañas, Laura Alvarez‐Jimenez, Diego Mora‐Gonzalez, Ricardo Mora‐Rodriguez
BackgroundMetabolic syndrome (MetS) is a set of five cardiometabolic risk factors that typically worsen with age. One exercise‐training programme is effective at improving those factors in middle‐aged individuals with MetS. To our knowledge, exercise‐training efficacy as MetS individuals age has not been explored. This study determined the effectiveness of a periodized exercise training programme for
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Transcriptional Co‐Activator With PDZ Binding Motif (TAZ) Inhibits Dexamethasone‐Induced Muscle Atrophy via mTOR Signalling J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-01 Kyung Min Kim, Ho Taek Oh, Youjin Do, Gi Don Yoo, Woong Heo, Jeekeon Park, Hyejin Yang, Suh Jin Yoon, Mi Ran Byun, Eun Sook Hwang, Jeong‐Ho Hong
BackgroundGlucocorticoid therapy has a beneficial effect in several diseases, but chronic treatment has adverse effects, including muscle atrophy, which refers to the gradual decrease in muscle mass, size and strength. It is important to know how the muscle atrophy occurs, but the underlying mechanism is not yet fully understood. This study shows that dexamethasone decreases levels of the transcriptional
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Longitudinal Cohort Study Investigating Fall Risk Across Diverse Muscle Health Statuses Among Older People in the Community J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-01 Yuan‐Ping Chao, Wen‐Hui Fang, Tao‐Chun Peng, Li‐Wei Wu, Hui‐Fang Yang, Tung‐Wei Kao
BackgroundFalls constitute a significant public health concern among older adults, particularly those with diminished muscle health integrity. The relative contributions of reduced muscle mass versus impaired muscle function to fall risk remain debated. Discrepant conclusions in previous studies exist due to divergent muscle health categorizations and parameter measurements. This study investigated
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Balancing LncRNA H19 and miR‐675 Bioconversion as a Key Regulator of Embryonic Myogenesis Under Maternal Obesity J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-01 Yao Gao, Md Nazmul Hossain, Liang Zhao, Xiangdong Liu, Yanting Chen, Jeanene Marie Deavila, Mei‐Jun Zhu, Gordon K. Murdoch, Min Du
BackgroundMaternal obesity (MO) impairs fetal skeletal muscle development, but the underlying mechanisms remain poorly defined. The regulatory roles of lncRNA H19 and its first exon derived microRNA675 (miR675) in prenatal muscle development remain to be examined. H19/Igf2 are in the same imprinting cluster with H19 expressed from the maternal allele while Igf2 expresses paternally. H19 contains a
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Plasma Extracellular Vesicles Biomarkers Linked to Lower Muscle Mass, Function and Physical Performance in Sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-01 Ji Yeon Kim, Tae‐Hwan Gil, Hyo Gyeong Lee, Ji‐Won Shin, Dong‐Hyun Jang, Hyeon Soo Kim, Seung Shin Park, Sang Wan Kim, Chan Soo Shin, Sung Hye Kong, Ok Hee Jeon
BackgroundAs society ages, identifying individuals at risk of sarcopenia becomes essential. Several plasma biomarkers are used to assess musculoskeletal status, but their results are inconsistent. Extracellular vesicles (EVs) are investigated as disease biomarkers due to their role in transporting molecules and influencing cellular processes. This study investigated the correlation of known sarcopenia
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A Causal Effect of Serum 25(OH)D Level on Appendicular Muscle Mass: Evidence From NHANES Data and Mendelian Randomization Analyses J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-04-01 Qian Ren, Jinrong Liang, Yanmei Su, Ruijing Tian, Junxian Wu, Sheng Ge, Peizhan Chen
BackgroundLow serum vitamin D status was reported to be associated with reduced muscle mass; however, it is inconclusive whether this relationship is causal. This study used data from the National Health and Nutrition Examination Survey (NHANES) and two‐sample Mendelian randomization (MR) analyses to ascertain the causal relationship between serum 25‐hydroxyvitamin D [25(OH)D] and appendicular muscle
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Body Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-30 Asmita Mishra, Ram Thapa, Kevin Bigam, Martine Extermann, Rawan Faramand, Farhad Khimani, Xuefeng Wang, Vickie Baracos, Joseph A. Pidala
BackgroundAdditional tools are needed to assess mortality risk among patients with cancer. Patients with chronic graft vs. host disease (cGVHD) after allogeneic haematopoietic cell transplantation (HCT) represent a high‐risk cancer population with mortality risk explained by cGVHD severity, but also informed by baseline comorbidities, functional status before and after HCT, and cumulative toxicity
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Correction to “The Prevalence Patterns and Risk Factor Profiles of Poor Muscle Health and Its Associated Components in Multi‐Ethnic Older Asians: The PIONEER Study” J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-28
Gupta, P, Vu, TA, Man, REK, et al., The prevalence patterns and risk factor profiles of poor muscle health and its associated components in multiethnic older Asians: The PIONEER study. Journal of cachexia, sarcopenia and muscle. Aug 2024; 15(4): 1376–1387. doi:10.1002/jcsm.13483 In the Funding ‘section’, we would like to add: “This research is supported by the National Medical Research Council (NMRC)
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A Novel Definition and Grading Diagnostic Criteria for Tumour‐Type‐Specific Comprehensive Cachexia Risk J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-23 Chunlei Hu, Minghua Cong, Chunhua Song, Hongxia Xu, Zengqing Guo, Fuxiang Zhou, Lan Zhou, Min Weng, Benqiang Rao, Li Deng, Kaiying Yu, Yongbing Chen, Ziwen Wang, Guotian Ruan, Ming Yang, Chenan Liu, Jiuwei Cui, Wei Li, Kunhua Wang, Zengning Li, Ming Liu, Tao Li, Junqiang Chen, Stephan von Haehling, Rocco Barazzoni, Hanping Shi
BackgroundThe existing diagnostic criteria for cancer cachexia do not meet clinical needs. We aimed to establish novel comprehensive evaluation scales for cachexia specific to patients with solid tumours.MethodsThis study included 12 651 patients (males: 6793 [53.7%]; females: 5858 [46.3%]; medium age: 58 [interquartile range:50/66] years; medium follow‐up duration: 24.16 [13.32/44.84] months; 4271
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snRNA‐Seq and Spatial Transcriptome Reveal Cell–Cell Crosstalk Mediated Metabolic Regulation in Porcine Skeletal Muscle J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-13 Liu Guo, Mengmeng Han, Junfei Xu, Wenyue Zhou, Hanjing Shi, Sisi Chen, Weijun Pang, Xing Zhang, Yehui Duan, Yulong Yin, Fengna Li
BackgroundCell–cell crosstalk between myogenic, adipogenic and immune cells in skeletal muscle to regulate energy metabolism and lipid deposition has received considerable attention. The specific mechanisms of interaction between the different cells in skeletal muscle are still unclear.MethodsUsing integrated analysis of snRNA‐seq and spatial transcriptome, the gene expression profile of longissimus
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Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-12 Qing‐Bo Lu, He‐Ting Sun, Kuo Zhou, Jia‐Bao Su, Xin‐Yu Meng, Guo Chen, Ao‐Yuan Zhang, An‐Jing Xu, Chen‐Yang Zhao, Yuan Zhang, Yao Wang, Hong‐Bo Qiu, Zhuo‐Lin Lv, Zheng‐Yang Bao, Jian Zhu, Feng Xiao, Xue‐Xue Zhu, Hai‐Jian Sun
BackgroundA significant increase in mitochondrial fatty acid oxidation (FAO) is now increasingly recognized as one of the metabolic alterations in diabetic cardiomyopathy (DCM). However, the molecular mechanisms underlying mitochondrial FAO impairment in DCM remain to be fully elucidated.MethodsA type 2 diabetes (T2D) mouse model was established by a combination of high‐fat diet (HFD) and streptozotocin
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Paradoxical Effect of Myosteatosis on the Immune Checkpoint Inhibitor Response in Metastatic Renal Cell Carcinoma J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-12 Jiwoong Yu, Hyeonju Ahn, Kyung Yeon Han, Wan Song, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Se Hoon Park, Woong‐Yang Park, Ji Hyun Lee, Minyong Kang
BackgroundTreatment for metastatic renal cell carcinoma (mRCC) has shifted from tyrosine kinase inhibitor (TKI) therapy to immune checkpoint inhibitor (ICI)–based therapy, improving outcomes but with variable individual responses. This study investigated the prognostic implications of pretreatment low skeletal muscle mass (LSMM) and myosteatosis in patients with mRCC undergoing first‐line ICI‐based
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An Attention‐Aware Multi‐Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-12 Md Selim Reza, Chuan Qiu, Xu Lin, Kuan‐Jui Su, Anqi Liu, Xiao Zhang, Yun Gong, Zhe Luo, Qing Tian, Martin Nwadiugwu, Shaung Liang, Hui Shen, Hong‐Wen Deng
BackgroundSarcopenia presents a pressing public health concern due to its association with age‐related muscle mass decline, strength loss and reduced physical performance, particularly in the growing older population. Given the absence of approved pharmacological therapies for sarcopenia, the need to discover effective pharmacological interventions has become critical.MethodsTo address this challenge
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Comment on “Change in Physical Activity and Its Association With Decline in Kidney Function: A UK Biobank‐Based Cohort Study” by Liu et al.—The Authors' Reply J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-12 Qiaoling Liu, Carlos Celis‐Morales, Jennifer S. Lees, Naveed Sattar, Frederick K. Ho, Jill P. Pell, Patrick B. Mark, Paul Welsh
We are grateful for the interest of Dr Wang et al. [1] in our study. Their letter raises several important points, and we are pleased to have the opportunity to address them. As Wang G et al. note, the UK Biobank does include accelerometer-measured physical activity data. However, these measurements were collected in a subset of participants (< 100 000) at a single time point, 8–10 years after the
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Comment on “Myosteatosis and Muscle Loss Impact Liver Transplant Outcomes in Male Patients With Hepatocellular Carcinoma” by Lu et al.—The Authors' Reply J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-12 Di Lu, Zhihang Hu, Hao Chen, Xiao Xu
We appreciate the interest and insightful comments by Kamiliou et al. [1] regarding our recently published study [2]. Our work incorporated 756 participants from 3 transplant centres and identified that pre-transplant myosteatosis aggravated the adverse impact of sarcopenia on liver transplant outcomes in male patients with hepatocellular carcinoma (HCC). In terms of the prevalence of myosteatosis
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Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta‐Analyses J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2025-03-12 Masoud Rahmati, Hyeri Lee, Hayeon Lee, Jaeyu Park, Djandan Tadum Arthur Vithran, Yusheng Li, Abdolreza Kazemi, Laurent Boyer, Guillaume Fond, Lee Smith, Nicola Veronese, Pinar Soysal, Elena Dragioti, Samuele Cortese, Jiseung Kang, Dong Keon Yon, Marco Solmi
BackgroundNumerous studies support the association of exercise training, physical activity (PA) and sedentary behaviour (SB) with both mortality and morbidity outcomes. The results across studies have been inconsistent, and no umbrella reviews have yet been conducted on this topic.MethodsWe conducted an umbrella review of meta‐analyses of observational studies by screening articles in PubMed/MEDLINE