样式: 排序: IF: - GO 导出 标记为已读
-
LRRK2G2019S Gene Mutation Causes Skeletal Muscle Impairment in Animal Model of Parkinson's Disease J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-23 Yiying Hu, Huijia Yang, Chunli Song, Lulu Tian, Panpan Wang, Tianbai Li, Cheng Cheng, Murad AlNusaif, Song Li, Zhanhua Liang, Weidong Le
BackgroundWhile the gradually aggravated motor and non‐motor disorders of Parkinson's disease (PD) lead to progressive disability and frequent falling, skeletal muscle impairment may contribute to this condition. The leucine‐rich repeat kinase2 (LRRK2) is a common disease‐causing gene in PD. Little is known about its role in skeletal muscle impairment and its underlying mechanisms.MethodsTo investigate
-
Sarcopenia interventions in long‐term care facilities targeting sedentary behaviour and physical inactivity: A systematic review J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-18 Yihan Mo, Linghui Chen, Yuxin Zhou, Anna Bone, Matthew Maddocks, Catherine J. Evans
BackgroundSedentary behaviour and physical inactivity are independent risk factors for sarcopenia for long‐term care facility residents. Understanding the components, mechanisms and context of interventions that target change in these risk factors can help optimize sarcopenia management approaches. This study aimed to identify, appraise and synthesize the interventions targeting sedentary behaviour
-
Frequency of weight and body composition increases in advanced non‐small cell lung cancer patients during first line therapy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-18 Philip Bonomi, Hita Moudgalya, Sandra L. Gomez, Palmi Shah, Sanjib Basu, Marta Batus, Levi B. Martinka, Ahmed Abdelkader, Iphigenia Tzameli, Sonia Cobain, Susie Collins, Edmund J. Keliher, Danna M. Breen, Roberto A. Calle, Mary Jo Fidler, Jeffrey A. Borgia
BackgroundThe primary objective of this study was to assess the frequency of body composition increases and their relationships to changes in body weight in two cohorts of real world, treatment‐naïve, advanced non‐small cell lung cancer (NSCLC) patients. One cohort received the current standard of care (CSOC), which consisted of immunotherapy and newer chemotherapy regimens, and the other cohort was
-
Adenosine A2B receptor activation regulates the balance between T helper 17 cells and regulatory T cells, and inhibits regulatory T cells exhaustion in experimental autoimmune myositis J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-17 Yueyuan Zhou, Limei Kang, Geng Yin, Leiyi Yang, Bo Chen, Binhan Liu, Xiaoyan Zhu, Qibing Xie
BackgroundIdiopathic inflammatory myopathy (IIM) is a systemic autoimmune disease characterized by skeletal muscle involvement. This study aimed to investigate the role of adenosine receptor signalling pathways in the development of experimental autoimmune myositis (EAM).MethodsAn ecto‐5′‐nucleotidase (CD73) inhibitor, adenosine receptor agonists, a hypoxia‐inducible factor‐1α (HIF‐1α) inhibitor or
-
Ubiquitylomics: An Emerging Approach for Profiling Protein Ubiquitylation in Skeletal Muscle J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-16 Samuel O. Lord, Harvey E. Johnston, Rahul S. Samant, Yu-Chiang Lai
Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and pathological factors. Whilst the pivotal role of skeletal muscle in overall health is widely acknowledged, unravelling the underlying molecular mechanisms poses ongoing challenges. Protein ubiquitylation, a crucial post-translational modification, is involved in regulating most biological processes. This widespread
-
High‐Intensity Interval Training Mitigates Sarcopenia and Suppresses the Myoblast Senescence Regulator EEF1E1 J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-14 Yaoshan Dun, Wenliang Zhang, Yang Du, Kangling Xie, Yuan Liu, Cui Li, Ling Qiu, Siqian Fu, Thomas P. Olson, Yuqiong Long, Baiyang You, Suixin Liu
BackgroundThe optimal exercise regimen for alleviating sarcopenia remains uncertain. This study aimed to investigate the efficacy of high‐intensity interval training (HIIT) over moderate‐intensity continuous training (MICT) in ameliorating sarcopenia.MethodsWe conducted a randomized crossover trial to evaluate plasma proteomic reactions to acute HIIT (four 4‐min high‐intensity intervals at 70% maximal
-
Novel insights into the association between genetically proxied inhibition of proprotein convertase subtilisin/kexin type 9 and risk of sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-10 Hongyan Jiang, Lulu Li, Xue Zhang, Jia He, Chuanhuai Chen, Ruimin Sun, Ying Chen, Lijuan Xia, Lei Wen, Yunxiang Chen, Junxiu Liu, Lijiang Zhang, Wanqiang Lv
BackgroundThe effects of lipid‐lowering drugs [including statins, ezetimibe, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors] on hyperlipidaemia have been established. Some may have treatment effects beyond their reported properties, offering potential opportunities for drug repurposing. Epidemiological studies have reported conflicting findings on the relationship between lipid‐lowering
-
Improved health by combining dietary restriction and promoting muscle growth in DNA repair‐deficient progeroid mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-09 Wilbert P. Vermeij, Khalid Alyodawi, Ivar van Galen, Jennie L. von der Heide, María B. Birkisdóttir, Lisanne J. van't Sant, Rutger A. Ozinga, Daphne S.J. Komninos, Kimberly Smit, Yvonne M.A. Rijksen, Renata M.C. Brandt, Sander Barnhoorn, Dick Jaarsma, Sathivel Vaiyapuri, Olli Ritvos, Tobias B. Huber, Oliver Kretz, Ketan Patel
BackgroundAgeing is a complex multifactorial process, impacting all organs and tissues, with DNA damage accumulation serving as a common underlying cause. To decelerate ageing, various strategies have been applied to model organisms and evaluated for health and lifespan benefits. Dietary restriction (DR, also known as caloric restriction) is a well‐established long‐term intervention recognized for
-
Neuromuscular impairment at different stages of human sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-05 Fabio Sarto, Martino V. Franchi, Jamie S. McPhee, Daniel W. Stashuk, Matteo Paganini, Elena Monti, Maira Rossi, Giuseppe Sirago, Sandra Zampieri, Evgeniia S. Motanova, Giacomo Valli, Tatiana Moro, Antonio Paoli, Roberto Bottinelli, Maria A. Pellegrino, Giuseppe De Vito, Helen M. Blau, Marco V. Narici
BackgroundDegeneration of the motoneuron and neuromuscular junction (NMJ) and loss of motor units (MUs) contribute to age‐related muscle wasting and weakness associated with sarcopenia. However, these features have not been comprehensively investigated in humans. This study aimed to compare neuromuscular system integrity and function at different stages of sarcopenia, with a particular focus on NMJ
-
The impact of mobility limitations on geriatric rehabilitation outcomes: Positive effects of resistance exercise training (RESORT) J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-05 Laure M. G. Verstraeten, Esmee M. Reijnierse, Thom Spoelstra, Carel G. M. Meskers, Andrea B. Maier
BackgroundRegaining walking ability is a key target in geriatric rehabilitation. This study evaluated the prevalence of walking ability at (pre‐)admission and related clinical characteristics in a cohort of geriatric rehabilitation inpatients; in inpatients without walking ability, feasibility and effectiveness of progressive resistance exercise training (PRT) were assessed.MethodsInpatients within
-
Sphingolipid metabolites as potential circulating biomarkers for sarcopenia in men J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-09-04 Je Hyun Seo, Jung‐Min Koh, Han Jin Cho, Hanjun Kim, Young‐Sun Lee, Su Jung Kim, Pil Whan Yoon, Won Kim, Sung Jin Bae, Hong‐Kyu Kim, Hyun Ju Yoo, Seung Hun Lee
BackgroundSarcopenia is an age‐related progressive loss of muscle mass and function. Sarcopenia is a multifactorial disorder, including metabolic disturbance; therefore, metabolites may be used as circulating biomarkers for sarcopenia. We aimed to investigate potential biomarkers of sarcopenia using metabolomics.MethodsAfter non‐targeted metabolome profiling of plasma from mice of an aging mouse model
-
Factors associated with handgrip strength across the life course: A systematic review J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-26 Leticia W. Ribeiro, Sara Berndt, Gregore I. Mielke, Jenny Doust, Gita D. Mishra
Muscle strength is essential for healthy ageing. Handgrip strength (HGS) has been recommended by expert bodies as the preferred measure of muscle strength, in addition to being considered a strong predictor of overall health. Cross-sectional studies have shown several potential factors associated with HGS, but a systematic review of factors predicting HGS over time has not previously been conducted
-
Artificial neural network inference analysis identified novel genes and gene interactions associated with skeletal muscle aging J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-30 Janelle Tarum, Graham Ball, Thomas Gustafsson, Mikael Altun, Lívia Santos
BackgroundSarcopenia is an age‐related muscle disease that increases the risk of falls, disabilities, and death. It is associated with increased muscle protein degradation driven by molecular signalling pathways including Akt and FOXO1. This study aims to identify genes, gene interactions, and molecular pathways and processes associated with muscle aging and exercise in older adults that remained undiscovered
-
Leptin signalling altered in infantile nephropathic cystinosis‐related bone disorder J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-30 Wai W. Cheung, Ping Zhou, Ronghao Zheng, Arieh Gertler, Eduardo A. Oliveira, Robert H. Mak
BackgroundThe CTNS gene mutation causes infantile nephropathic cystinosis (INC). Patients with INC develop Fanconi syndrome and chronic kidney disease (CKD) with significant bone deformations. C57BL/6 Ctns−/− mice are an animal model for studying INC. Hyperleptinaemia results from the kidney's inability to eliminate the hormone leptin in CKD. Ctns−/− mice have elevated serum leptin concentrations.
-
Overall mortality for community‐dwelling adults over 50 years at risk of malnutrition J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-30 Matthew Gittins, Nada AlMohaisen, Chris Todd, Simon Lal, Sorrel Burden
BackgroundIt is well reported that malnutrition in acute care is associated with poorer health outcomes including increased mortality. However, the consequences of malnutrition on survival in community settings is uncertain. Malnutrition in people 65 years or over is often cited. Nevertheless, this study includes both middle‐aged and older adults as current public health policy is highlighting the
-
AWGC2023 cachexia consensus as a valuable tool for predicting prognosis and burden in Chinese patients with cancer J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-28 Hailun Xie, Lishuang Wei, Guotian Ruan, Heyang Zhang, Jinyu Shi, Shiqi Lin, Chenan Liu, Xiaoyue Liu, Xin Zheng, Yue Chen, Junqiang Chen, Hanping Shi
BackgroundThe Asian Working Group for Cachexia (AWGC) proposed the first consensus report on diagnostic criteria for cachexia in Asians in 2023. However, the current consensus lacks cohort evidence to validate its effectiveness and practicality. We aimed to explore the value of the AWGC2023 criteria for predicting the prognosis and medical burden of patients with cancer through a retrospective post
-
Myosteatosis and muscle loss impact liver transplant outcomes in male patients with hepatocellular carcinoma J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-28 Di Lu, Zhihang Hu, Hao Chen, Abid Ali Khan, Qingguo Xu, Zuyuan Lin, Huigang Li, Jianyong Zhuo, Chiyu He, Li Zhuang, Zhe Yang, Siyi Dong, Jinzhen Cai, Shusen Zheng, Xiao Xu
BackgroundSarcopenia is associated with unfavourable long‐term survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC). However, the impact of myosteatosis and muscle loss on patient prognosis has not been investigated.MethodsSeven hundred fifty‐six HCC patients who received LT at 3 transplant centres were included. Computed tomography (CT) images of recipients
-
Associations between gut microbiota and sarcopenia or its defining parameters in older adults: A systematic review J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-28 Laurence Lapauw, Aurélie Rutten, Jolan Dupont, Nadjia Amini, Laura Vercauteren, Muriel Derrien, Jeroen Raes, Evelien Gielen
Altered gut microbiota (GM) potentially contribute to development or worsening of sarcopenia through a gut‐muscle axis. This systematic review aims to compare GM between persons with sarcopenia or low sarcopenia‐defining parameters (muscle mass, strength, and physical performance) to those with preserved muscle status, as well as to clarify possible associations between sarcopenia (‐defining parameters)
-
TRIM16 facilitates SIRT‐1‐dependent regulation of antioxidant response to alleviate age‐related sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-28 Ai Guo, Ke Huang, Quanyi Lu, Bailong Tao, Kai Li, Dianming Jiang
BackgroundAge‐related sarcopenia, characterized by reduced skeletal muscle mass and function, significantly affects the health of the elderly individuals. Oxidative stress plays a crucial role in the development of sarcopenia. Tripartite motif containing 16 (TRIM16) is implicated in orchestrating antioxidant responses to mitigate oxidative stress, yet its regulatory role in skeletal muscle remains
-
Hydrogen sulfide inhibits skeletal muscle ageing by up‐regulating autophagy through promoting deubiquitination of adenosine 5’‐monophosphate (AMP)‐activated protein kinase α1 via ubiquitin specific peptidase 5 J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-27 Jia‐He Yang, Jun Gao, Ya‐Qi E, Li‐Jie Jiao, Ren Wu, Qiu‐Yi Yan, Zi‐Yi Wei, Guo‐Liang Yan, Jin‐Long Liang, Hong‐Zhu Li
BackgroundHydrogen sulfide (H2S), the third gasotransmitter discovered, regulates a variety of physiological functions. Whether H2S alleviates skeletal muscle ageing by regulating autophagy has not been reported.MethodsMice were administered 150 mg/kg/day of D‐galactose ( D‐gal), and C2C12 myotubes were cultured in 20 g/L D‐gal to induce ageing. Sodium hydrosulfide (NaHS) was employed as an exogenous
-
Detection of cancer‐associated cachexia in lung cancer patients using whole‐body [18F]FDG‐PET/CT imaging: A multi‐centre study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-27 Daria Ferrara, Elisabetta M. Abenavoli, Thomas Beyer, Stefan Gruenert, Marcus Hacker, Swen Hesse, Lukas Hofmann, Smilla Pusitz, Michael Rullmann, Osama Sabri, Roberto Sciagrà, Lalith Kumar Shiyam Sundar, Anke Tönjes, Hubert Wirtz, Josef Yu, Armin Frille
BackgroundCancer‐associated cachexia (CAC) is a metabolic syndrome contributing to therapy resistance and mortality in lung cancer patients (LCP). CAC is typically defined using clinical non‐imaging criteria. Given the metabolic underpinnings of CAC and the ability of [18F]fluoro‐2‐deoxy‐D‐glucose (FDG)‐positron emission tomography (PET)/computer tomography (CT) to provide quantitative information
-
Betaine delays age‐related muscle loss by mitigating Mss51‐induced impairment in mitochondrial respiration via Yin Yang1 J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-27 Si Chen, Tongtong He, Jiedong Chen, Dongsheng Wen, Chen Wang, Wenge Huang, Zhijun Yang, Mengtao Yang, Mengchu Li, Siyu Huang, Zihui Huang, Huilian Zhu
BackgroundMitochondrial dysfunction is one of the hallmarks of aging and a leading contributor to sarcopenia. Nutrients are essential for improving mitochondrial function and skeletal muscle health during the aging process. Betaine is a nutrient with potential muscle‐preserving properties. However, whether and how betaine could regulate the mitochondria function in aging muscle are poorly understood
-
Body composition parameters in initial CT imaging of mechanically ventilated trauma patients: Single‐centre observational study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-26 Hans‐Jonas Meyer, Tihomir Dermendzhiev, Michael Hetz, Georg Osterhoff, Christian Kleber, Timm Denecke, Jeanette Henkelmann, Robert Werdehausen, Gunther Hempel, Manuel F. Struck
BackgroundBody composition parameters provide relevant prognostic significance in critical care cohorts and cancer populations. Published results regarding polytrauma patients are inconclusive to date. The goal of this study was to analyse the role of body composition parameters in severely injured trauma patients.MethodsAll consecutive patients requiring emergency tracheal intubation and mechanical
-
Exploring the utility of ultrasound to assess disuse atrophy in different muscles of the lower leg J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-26 Edward J. Hardy, Joseph J. Bass, Thomas B. Inns, Mathew Piasecki, Jessica Piasecki, Craig Sale, Robert H. Morris, Jonathan N. Lund, Ken Smith, Daniel J. Wilkinson, Philip J. Atherton, Bethan E. Phillips
BackgroundSkeletal muscle is a highly plastic tissue crucial for many functions associated with whole‐body health across the life course. Magnetic resonance imaging (MRI) is the current gold standard for measuring skeletal muscle size. However, MRI is expensive, and access to facilities is often limited. B‐mode ultrasonography (U/S) has been proposed as a potential alternative to MRI for the assessment
-
Novel metabolic and lipidomic biomarkers of sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-22 Wei‐Hsiang Hsu, San‐Yuan Wang, Yen‐Ming Chao, Ke‐Vin Chang, Der‐Sheng Han, Yun‐Lian Lin
BackgroundThe pathophysiology of sarcopenia is complex and multifactorial and has not been fully elucidated. The impact of resistance training and nutritional support (RTNS) on metabolomics and lipodomics in older adults with sarcopenia remains uncertain. This study aimed to explore potential biomarkers of sarcopenia and clinical indicators of RTNS in older sarcopenic adults.MethodsOlder individuals
-
Survey on the knowledge and practices in anorexia of aging diagnosis and management in Japan J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-22 Sahoko Takagi, Shosuke Satake, Ken Sugimoto, Masafumi Kuzuya, Masahiro Akishita, Hidenori Arai, Ivan Aprahamian, Andrew J. Coats, Tatiana Klompenhouwer, Stefan D. Anker, Hidetaka Wakabayashi
BackgroundAnorexia of aging (AA) is a condition in older adults that includes loss of appetite and reduced food intake. There is a lack of detailed analysis of the potential influence of educational initiatives in addressing AA. This study aimed to clarify the current state of knowledge and practice regarding AA and its relationship with the availability of continuing education opportunities among
-
Co-morbid sarcopenia and low bone mineral density in young paediatric cancer survivors J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-20 Andres Marmol-Perez, Esther Ubago-Guisado, Jose J. Gil-Cosano, Francisco J. Llorente-Cantarero, Juan Francisco Pascual-Gázquez, Manuel Muñoz-Torres, Vicente Martinez-Vizcaino, Kirsten K. Ness, Jonatan R. Ruiz, Luis Gracia-Marco
Sarcopenia and low areal bone mineral density (aBMD) are prevalent musculoskeletal complications after paediatric cancer treatment. However, their relationship has not been examined in young paediatric cancers survivors. This study aimed to evaluate aBMD differences according to sarcopenia status and the risk of low aBMD Z-score in young paediatric cancer survivors with sarcopenia confirmed/probable
-
Change in physical activity and its association with decline in kidney function: A UK Biobank‐based cohort study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-19 Qiaoling Liu, Carlos Celis‐Morales, Jennifer S. Lees, Naveed Sattar, Frederick K. Ho, Jill P. Pell, Patrick B. Mark, Paul Welsh
BackgroundPrevious research on the association between physical activity (PA) and kidney function is inconsistent. The association between muscle mass and serum creatinine (SCr) may have implications for interpreting the effect of PA on estimated glomerular filtration rate (eGFR). Few studies have reported changes in physical activity and changes in kidney function.MethodsA cohort study was constructed
-
Higher serum uric acid as a risk factor for frailty in older adults: A nationwide population‐based study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-19 Min‐gu Kang, Ji Yeon Baek, Yunju Jo, Dongryeol Ryu, Il‐Young Jang, Hee‐Won Jung, Beom‐Jun Kim
BackgroundUric acid (UA), the terminal breakdown product of purine metabolism, possesses contradictory roles, functioning both as an inflammatory mediator and as an antioxidant. Its clinical relevance, particularly in geriatric populations, remains a topic of ongoing debate. Aiming to elucidate whether circulating UA is detrimental or beneficial to human health, we investigate the association between
-
The maternal lifestyle in pregnancy: Implications for foetal skeletal muscle development J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-18 Haijun Sun, Meixia Chen, Jialong Liao, Linjuan He, Boyang Wan, Jingdong Yin, Xin Zhang
The world is facing a global nutrition crisis, as evidenced by the rising incidence of metabolic disorders such as obesity, insulin resistance and chronic inflammation. Skeletal muscle is the largest tissue in humans and plays an important role in movement and host metabolism. Muscle fibre formation occurs mainly during the embryonic stage. Therefore, maternal lifestyle, especially nutrition and exercise
-
Regimen on Dnaja3 haploinsufficiency mediated sarcopenic obesity with imbalanced mitochondrial homeostasis and lipid metabolism J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-12 Yu‐Ning Fann, Wan‐Huai Teo, Hsin‐Chen Lee, Chen‐Chung Liao, Yeou‐Guang Tsay, Tung‐Fu Huang, Jeng‐Fan Lo
BackgroundSarcopenic obesity is characterized by excess fat mass and diminished muscular mass/function. DNAJA3, a mitochondrial co‐chaperone protein, plays a crucial role in skeletal muscle development. GMI, an immunomodulatory protein, promotes myogenic differentiation through DNAJA3 activation. This study aims to elucidate the physiological effects of muscular Dnaja3 haploinsufficiency on mitochondrial
-
Different outcomes of endurance and resistance exercise in skeletal muscles of Oculopharyngeal muscular dystrophy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-08 Alexis Boulinguiez, Jamila Dhiab, Barbara Crisol, Laura Muraine, Ludovic Gaut, Corentin Rouxel, Justine Flaire, Hadidja‐Rose Mouigni, Mégane Lemaitre, Benoit Giroux, Lucie Audoux, Benjamin SaintPierre, Arnaud Ferry, Vincent Mouly, Gillian Butler‐Browne, Elisa Negroni, Alberto Malerba, Capucine Trollet
BackgroundExercise is widely considered to have beneficial impact on skeletal muscle aging. In addition, there are also several studies demonstrating a positive effect of exercise on muscular dystrophies. Oculopharyngeal muscular dystrophy (OPMD) is a late‐onset autosomal dominant inherited neuromuscular disorder caused by mutations in the PAPBN1 gene. These mutations consist in short (1‐8) and meiotically
-
The mortality burden of cachexia or weight loss in patients with colorectal or pancreatic cancer: A systematic literature review J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-03 Richard F. Dunne, Jeffrey Crawford, Karen E. Smoyer, Thomas D. McRae, Michelle I. Rossulek, James H. Revkin, Lisa C. Tarasenko, Philip D. Bonomi
Cancer‐associated cachexia is a multifactorial wasting disorder characterized by anorexia, unintentional weight loss (skeletal muscle mass with or without loss of fat mass), progressive functional impairment, and poor prognosis. This systematic literature review (SLR) examined the relationship between cachexia and survival in patients with colorectal or pancreatic cancer in recent literature. The SLR
-
l‐Carnitine relieves cachexia‐related skeletal muscle fibrosis by inducing deltex E3 ubiquitin ligase 3L to negatively regulate the Runx2/COL1A1 axis J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-02 Zongliang Lu, Li Wang, Zhenyu Huo, Na Li, Ning Tong, Feifei Chong, Jie Liu, Yaowen Zhang, Hongxia Xu
BackgroundCancer cachexia‐induced skeletal muscle fibrosis (SMF) impairs muscle regeneration, alters the muscle structure and function, reduces the efficacy of anticancer drugs, diminishes the patient's quality of life and shortens overall survival. RUNX family transcription factor 2 (Runx2), a transcription factor, and collagen type I alpha 1 chain (COL1A1), the principal constituent of SMF, have
-
Issue Information J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-08-02
No abstract is available for this article.
-
Sex similarities and divergences in systemic and muscle iron metabolism adaptations to extreme physical inactivity in rats J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-25 Mathieu Horeau, Melissa Delalande, Martine Ropert, Patricia Leroyer, Brice Martin, Luz Orfila, Olivier Loréal, Frédéric Derbré
BackgroundPrevious data in humans suggest that extreme physical inactivity (EPI) affects iron metabolism differently between sexes. Our objective was to deepen the underlying mechanisms by studying rats of both sexes exposed to hindlimb unloading (HU), the reference experimental model mimicking EPI.MethodsEight‐week‐old male and female Wistar rats were assigned to control (CTL) or hindlimb unloading
-
Factors associated with skeletal muscle mass in middle‐aged men living with HIV J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-17 Yide Xu, Dongdong Wang, Pei Chen, Bufeng Qi, Xiaoting Li, Chunfeng Xie, Jieshu Wu, Lin Li, Gu Gao, Shanshan Geng, Dandan Yang
BackgroundDespite extensive research on muscle loss in people living with HIV (PLWH), the prevalence and contributing factors specifically among middle‐aged men remain unclear. This study aimed to determine the prevalence of low muscle mass within this demographic and to identify associated factors.MethodsA total of 378 men living with HIV were enrolled in the study. They were classified into low muscle
-
Roles of programmed death‐1 and muscle innate lymphoid cell‐derived interleukin 13 in sepsis‐induced intensive care unit‐acquired weakness J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-17 Yuichi Akama, Eun Jeong Park, Naoko Satoh‐Takayama, Atsushi Ito, Eiji Kawamoto, Arong Gaowa, Eri Matsuo, Satoshi Oikawa, Masafumi Saito, Shigeaki Inoue, Takayuki Akimoto, Kei Suzuki, Motomu Shimaoka
BackgroundIntensive care unit‐acquired weakness (ICU‐AW) is a syndrome characterized by a long‐term muscle weakness often observed in sepsis‐surviving patients during the chronic phase. Although ICU‐AW is independently associated with increased mortality, effective therapies have yet to be established. Programmed death‐1 (PD‐1) inhibitors have attracted attention as potential treatments for reversing
-
Association between metabolic dysfunction‐associated steatotic liver disease and myosteatosis measured by computed tomography J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-16 Myung Jin Kim, Yun Kyung Cho, Eun Hee Kim, Min Jung Lee, Woo Je Lee, Hong‐Kyu Kim, Chang Hee Jung
BackgroundIn 2023, the concept of metabolic dysfunction‐associated steatotic liver disease (MASLD) was introduced as an alternative to non‐alcoholic fatty liver disease (NAFLD). We aimed to assess the quantity and quality of skeletal muscle using each of these diagnostic classifications.MethodsThis cross‐sectional study included 18 154 participants (11 551 [63.6%] men and 6603 [36.4%] women, mean age
-
Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-16 Paula Aparicio, David Navarrete‐Villanueva, Alba Gómez‐Cabello, Tresa López‐Royo, Enrique Santamaría, Joaquín Fernández‐Irigoyen, Karina Ausín, Manuel Arruebo, Victor Sebastian, Germán Vicente‐Rodríguez, Rosario Osta, Raquel Manzano
BackgroundSarcopenia, the gradual and generalized loss of muscle mass and function with ageing, is one of the major health problems in older adults, given its high prevalence and substantial socioeconomic implications. Despite the extensive efforts to reach consensus on definition and diagnostic tests and cut‐offs for sarcopenia, there is an urgent and unmet need for non‐invasive, specific and sensitive
-
Skeletal muscle p53‐depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-16 Georgia Lenihan‐Geels, Francisco Garcia Carrizo, Marina Leer, Sabrina Gohlke, Moritz Oster, Sophie Pöhle‐Kronawitter, Christiane Ott, Alexandra Chadt, Isabel N. Reinisch, Markus Galhuber, Chen Li, Wenke Jonas, Markus Jähnert, Susanne Klaus, Hadi Al‐Hasani, Tilman Grune, Annette Schürmann, Tobias Madl, Andreas Prokesch, Michael Schupp, Tim J. Schulz
BackgroundThe ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development of diabetes and obesity. The tumour suppressor protein, p53, has been linked to the control of energy metabolism. We assessed its role in the acute control of nutrient
-
Association between myosteatosis and impaired glucose metabolism: A deep learning whole‐body magnetic resonance imaging population phenotyping approach J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-16 Matthias Jung, Hanna Rieder, Marco Reisert, Susanne Rospleszcz, Johanna Nattenmueller, Annette Peters, Christopher L. Schlett, Fabian Bamberg, Jakob Weiss
BackgroundThere is increasing evidence that myosteatosis, which is currently not assessed in clinical routine, plays an important role in risk estimation in individuals with impaired glucose metabolism, as it is associated with the progression of insulin resistance. With advances in artificial intelligence, automated and accurate algorithms have become feasible to fill this gap.MethodsIn this retrospective
-
Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-15 Andrew M. Holwerda, Marlou L. Dirks, Pierre‐Andre Barbeau, Joy Goessens, Annemie Gijsen, Luc J.C. van Loon, Graham P. Holloway
BackgroundMitochondria represent key organelles influencing cellular homeostasis and have been implicated in the signalling events regulating protein synthesis.MethodsWe examined whether mitochondrial bioenergetics (oxidative phosphorylation and reactive oxygen species (H2O2) emission, ROS) measured in vitro in permeabilized muscle fibres represent regulatory factors for integrated daily muscle protein
-
A multi‐omics approach to overeating and inactivity‐induced muscle atrophy in db/db mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Takuro Okamura, Masahide Hamaguchi, Genki Kobayashi, Takahiro Ichikawa, Yuka Hasegawa, Tomoki Miyoshi, Takafumi Senmaru, Naoko Nakanishi, Ryoichi Sasano, Michiaki Fukui
BackgroundOvereating and inactivity are associated with type 2 diabetes. This study aimed to investigate its pathological basis using integrated omics and db/db/mice, a model representing this condition.MethodsThe study involved housing 8‐week‐old db/m and db/db mice for 8 weeks. Various analyses were conducted, including gene expression in skeletal muscle and small intestine using next‐generation
-
Tumour‐induced alterations in single‐nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Samet Agca, Aylin Domaniku‐Waraich, Sevval Nur Bilgic, Melis Sucuoglu, Meric Dag, Sukru Anil Dogan, Serkan Kir
BackgroundTumour‐induced skeletal muscle wasting in the context of cancer cachexia is a condition with profound implications for patient survival. The loss of muscle mass is a significant clinical obstacle and is linked to reduced tolerance to chemotherapy and increased frailty. Understanding the molecular mechanisms driving muscle atrophy is crucial for the design of new therapeutics.MethodsLewis
-
Differential impacts of fat and muscle mass on cardiovascular and non‐cardiovascular mortality in individuals with type 2 diabetes J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Jie Guo, Yuxia Wei, Emerald G. Heiland, Anna Marseglia
BackgroundThe distribution of fat and muscle mass in different regions of the body can reflect different pathways to mortality in individuals with diabetes. Therefore, we investigated the associations between whole‐body and regional body fat and muscle mass with cardiovascular disease (CVD) and non‐CVD mortality in type 2 diabetes (T2D).MethodsWithin the National Health and Nutrition Examination Survey
-
Bidirectional transitions of sarcopenia states in older adults: The longitudinal evidence from CHARLS J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Ya‐Xi Luo, Xiao‐Han Zhou, Tian Heng, Ling‐Ling Yang, Ying‐Hai Zhu, Peng Hu, Xiu‐Qing Yao
BackgroundSarcopenia, the age‐related loss of muscle mass and function, brings multiple adverse outcomes including disability and death. Several sarcopenia consensuses have newly introduced the premorbid concept of possible sarcopenia and recommended early lifestyle interventions. Bidirectional transitions of premorbid states have been revealed in several chronic diseases yet not clarified in sarcopenia
-
A new computed tomography‐based approach to quantify swallowing muscle volume by measuring tongue muscle area in a single slice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-13 Javier Hurtado‐Oliva, Aniek T. Zwart, Jeroen Vister, Anouk van der Hoorn, Roel J.H.M. Steenbakkers, Inge Wegner, Gyorgy B. Halmos
BackgroundMeasuring the swallowing muscle mass with volume measurements is complex and time intensive; therefore, it is not used in clinical practice. However, it can be clinically relevant, for instance, in the case of sarcopenic dysphagia. The aim of the study was to develop a feasible and clinically applicable method to measure swallowing muscle mass.MethodsData from 10 head and neck cancer patients
-
Curcumin‐activated Wnt5a pathway mediates Ca2+ channel opening to affect myoblast differentiation and skeletal muscle regeneration J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-10 Mao‐yuan Wang, Jia‐ming Yang, Yi Wu, Hai Li, Yan‐biao Zhong, Yun Luo, Rui‐lian Xie
BackgroundSkeletal muscle injury is one of the most common sports injuries; if not properly treated or not effective rehabilitation treatment after injury, it can be transformed into chronic cumulative injury. Curcumin, an herbal ingredient, has been found to promote skeletal muscle injury repair and regeneration. The Wnt5a pathway is related to the expression of myogenic regulatory factors, and Ca2+
-
KLF13 restrains Dll4‐muscular Notch2 axis to improve the muscle atrophy J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-08 Shu Yang, Lijiao Xiong, Guangyan Yang, Jiaqing Xiang, Lixing Li, Lin Kang, Zhen Liang
BackgroundMuscle atrophy can cause muscle dysfunction and weakness. Krüppel‐like factor 13 (KLF13), a central regulator of cellular energy metabolism, is highly expressed in skeletal muscles and implicated in the pathogenesis of several diseases. This study investigated the role of KLF13 in muscle atrophy, which could be a novel therapeutic target.MethodsThe effects of gene knockdown and pharmacological
-
Sarcopenia is associated with short- and long-term mortality in patients with acute-on-chronic liver failure J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-05 Fan Zeng, Wei Jiang, Xiujun Chang, Fuxun Yang, Xiaoxiu Luo, Rongan Liu, Yu Lei, Jiajia Li, Chun Pan, Xiaobo Huang, Huaiqiang Sun, Yunping Lan
While sarcopenia is recognized as a predictor of mortality in cirrhosis, its influence on acute-on-chronic liver failure (ACLF) remains uncertain. Despite multiple studies examining the impact of sarcopenia on short-term mortality in patients with ACLF, the sample size of these studies was limited, and their outcomes were inconsistent. Therefore, this study aimed to explore the impact of sarcopenia
-
Targeted nutritional intervention attenuates experimental lung cancer cachexia J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-04 Wouter R. P. H. van de Worp, Jan Theys, Cecile J. A. Wolfs, Frank Verhaegen, Annemie M. W. J. Schols, Ardy van Helvoort, Ramon C. J. Langen
Cachexia, a syndrome with high prevalence in non-small cell lung cancer patients, impairs quality of life and reduces tolerance and responsiveness to cancer therapy resulting in decreased survival. Optimal nutritional care is pivotal in the treatment of cachexia and a recommended cornerstone of multimodal therapy. Here, we investigated the therapeutic effect of an intervention diet consisting of a
-
The life‐course changes in muscle mass using dual‐energy X‐ray absorptiometry: The China BCL study and the US NHANES study J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-07-02 Xi Wang, Liwang Gao, Jingfan Xiong, Hong Cheng, Li Liu, Hongbo Dong, Yiwen Huang, Hongmin Fan, Xia Wang, Xinying Shan, Pei Xiao, Junting Liu, Yinkun Yan, Jie Mi
BackgroundSarcopenia is an important indicator of ill health and is linked to increased mortality and a reduced quality of life. Age‐associated muscle mass indices provide a critical tool to help understand the development of sarcopenia. This study aimed to develop sex‐ and age‐specific percentiles for muscle mass indices in a Chinese population and to compare those indices with those from other ethnicities
-
Telerehabilitation improves cardiorespiratory and muscular fitness and body composition in older people with post‐COVID‐19 syndrome J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-28 Eulogio Pleguezuelos, Amin Del Carmen, Eva Moreno, Mateu Serra‐Prat, Noemí Serra‐Payá, Manuel Vicente Garnacho‐Castaño
BackgroundThe effects of post‐coronavirus disease 2019 (COVID‐19) syndrome on the cardiorespiratory and muscular fitness in older people are of utmost relevance. This study aimed to evaluate the effects of a 12‐week telerehabilitation programme on cardiorespiratory and muscular fitness and body composition in older patients with post‐COVID‐19 syndrome.MethodsOne hundred twenty older patients with post‐COVID‐19
-
Sarcopenia‐related changes in serum GLP‐1 level affect myogenic differentiation J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-27 Hsien‐Hao Huang, Yun‐Jie Wang, Hui‐Yu Jiang, Helen Wenshin Yu, Yin‐Quan Chen, Arthur Chiou, Jean‐Cheng Kuo
BackgroundSarcopenia, a group of muscle‐related disorders, leads to the gradual decline and weakening of skeletal muscle over time. Recognizing the pivotal role of gastrointestinal conditions in maintaining metabolic homeostasis within skeletal muscle, we hypothesize that the effectiveness of the myogenic programme is influenced by the levels of gastrointestinal hormones in the bloodstream, and this
-
Aerobic exercise suppresses CCN2 secretion from senescent muscle stem cells and boosts muscle regeneration in aged mice J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-26 Fan Li, Fulong Zhang, Haiwang Shi, Honglin Xia, Xiaobei Wei, Siqi Liu, Tao Wu, Yuecheng Li, Feng Shu, Mengjie Chen, Jie Li, Rui Duan
BackgroundAging negatively impacts tissue repair, particularly in skeletal muscle, where the regenerative capacity of muscle stem cells (MuSCs) diminishes with age. Although aerobic exercise is known to attenuate skeletal muscle atrophy, its specific impact on the regenerative and repair capacity of MuSCs remains unclear.MethodsMice underwent moderate‐intensity continuous training (MICT) from 9 months
-
Sarcopenia is independently associated with poor preoperative physical fitness in patients undergoing colorectal cancer surgery J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-26 Jason Rai, Edward T. Pring, Katrina Knight, Henry Tilney, Judy Gudgeon, Mark Gudgeon, Fiona Taylor, Laura E. Gould, Joel Wong, Stefano Andreani, Dinh V.C. Mai, Ioanna Drami, Phillip Lung, Thanos Athanasiou, Campbell Roxburgh, John T. Jenkins
BackgroundAccurate preoperative risk assessment for major colorectal cancer (CRC) surgery remains challenging. Body composition (BC) and cardiopulmonary exercise testing (CPET) can be used to evaluate risk. The relationship between BC and CPET in patients undergoing curative CRC surgery is unclear.MethodsConsecutive patients undergoing CPET prior to CRC surgery between 2010 and 2020 were identified
-
Test–retest reliability and follow‐up of muscle magnetic resonance elastography in adults with and without muscle diseases J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-25 Bram De Wel, Lotte Huysmans, Ronald Peeters, Stefan Ghysels, Kris Byloos, Guido Putzeys, Frederik Maes, Patrick Dupont, Kristl G. Claeys
BackgroundWe investigated the potential of magnetic resonance elastography (MRE) stiffness measurements in skeletal muscles as an outcome measure, by determining its test–retest reliability, as well as its sensitivity to change in a longitudinal follow‐up study.MethodsWe assessed test–retest reliability of muscle MRE in 20 subjects with (n = 5) and without (n = 15) muscle diseases and compared this
-
Cachexia in preclinical rheumatoid arthritis: Longitudinal observational study of thigh magnetic resonance imaging from osteoarthritis initiative cohort J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-25 Kamyar Moradi, Bahram Mohajer, Ali Guermazi, C. Kent Kwoh, Clifton O. Bingham, Soheil Mohammadi, Xu Cao, Mei Wan, Frank W. Roemer, Shadpour Demehri
BackgroundPreclinical rheumatoid arthritis (Pre‐RA) is defined as the early stage before the development of clinical RA. While cachexia is a well‐known and potentially modifiable complication of RA, it is not known if such an association exists also in the Pre‐RA stage. To investigate such issue, we aimed to compare the longitudinal alterations in the muscle composition and adiposity of participants
-
The association between dynamic changes in vitamin D and frailty alterations: A prospective analysis of UK Biobank participants J. Cachexia Sarcopenia Muscle (IF 9.4) Pub Date : 2024-06-24 Pan Zhang, Jinghui Zhong, Xinfeng Liu, Wen Sun
BackgroundFrailty is a common geriatric syndrome associated with reduced reserves and increased vulnerability to stressors among older adults. Vitamin D deficiency has been implicated in frailty, as it is essential for maintaining musculoskeletal functions. The relationship between dynamic changes in vitamin D levels and frailty over time has not been extensively studied.MethodsThis study utilized