To understand how the Donor Conception Identity Questionnaire (DCIQ) correlates with mental health and explore differences in the DCIQ between donor conceived people who were actively searching for donor connections to those who were not and those who had found their donor connections to those who had not. Cross-sectional survey. Online survey conducted within United Kingdom. A total of 88 donor conceived

Birth rates continue to decline as more women experience fertility issues. Assisted reproductive technologies are available for patients seeking fertility treatment, including cryopreservation techniques. Cryopreservation can be performed on gametes, embryos, or gonadal tissue and can be used for patients who desire to delay in vitro fertilization treatment. This review focuses on ovarian tissue cryopreservation

To evaluate associations between preconception 25-hydroxyvitamin D (25(OH)D) levels and biomarkers in female and male partners on live birth (LB), pregnancy loss, and semen quality. Secondary analysis using the folic acid and zinc supplementation trial of couples seeking infertility treatment at four US centers (2013–2017). A target trial emulation framework was applied to estimate associations. Couples

Preimplantation genetic testing for aneuploidy (PGT-A) to deselect aneuploid embryos in assisted reproductive technology (ART) treatment cycles may hold promise by augmenting pregnancy rates per transfer and reducing pregnancy loss rates for patients with unexplained recurrent pregnancy loss (RPL). To explore effectiveness of PGT-A in managing unexplained RPL by evaluating several key aspects: the

To evaluate population characteristics and obstetric complications after abdominal myomectomy vs. laparoscopic myomectomy. Retrospective cohort study. Healthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP-NIS) data representative of over 20% of all hospital admissions in the United States. A total of 13,868 and 338 pregnancies after abdominal or laparoscopic myomectomy, respectively

Findings from several high profile meta-analyses have raised concerns about an ongoing global decline in sperm concentration and male fertility. However, these studies exhibit considerable heterogeneity in key variables including study population, methodology, fertility status, and geographic region. To perform a systematic review and meta-analysis exploring temporal trends in sperm concentration among

To determine whether we can safely and successfully transplant an ovary tissue allograft from a nonidentical donor to her Turner syndrome sister. Transplantation of cryopreserved ovary tissue, as well as fresh transplantation of ovarian tissue between identical twins, is now well established with numerous reported successful cases. However, there have not yet been any ovary transplants between nonidentical

To study cycle outcomes of women who choose to pursue oocyte cryopreservation, using published age-specific oocyte recommendations. Retrospective cohort. Clinic. A total of 5,915 patients seeking planned oocyte cryopreservation, 3,504 ultimately underwent ovarian stimulation with oocyte retrieval and cryopreservation, 425 of this cohort subsequently thawed with intent to use embryo transfer. Planned

To determine the optimal number of fresh donor oocytes to expose to sperm for patients who want to prioritize reducing surplus embryos while preserving the live birth rate. Cross-sectional study. University. Patients who underwent their first in vitro fertilization of fresh donor oocytes at a single academic institution between January 2013 and November 2022. Patients were excluded if they used a directed

Endometriosis is an inflammatory disease, with different forms of expression and a variety of complaints. An endometrioma, an ovarian cyst with endometrium-like lining, is one of the most common expressions of abdominal endometriosis. These endometriomas can, in addition to medical treatment, be treated surgically. After surgery, hormonal therapy is still frequently used for the treatment of endometriosis

To investigate the association between oral contraceptive (OC) pill use and the risk of developing multiple sclerosis (MS), attempting to address the limitations present in previous studies that produced conflicting results. A population-based cohort study using data from the UK Biobank. The study included 181,058 women of white ethnicity born in England between 1937 and 1970, among which 1,131 had

To determine whether industry payments to physicians are associated with a difference in assisted reproductive technology practices and outcomes. Retrospective cohort. Assisted reproductive technology centers. Patients undergoing asissted reproduction. Industry payments reported to the Open Payments 2020 database. The live birth rate, frozen embryo transfer (FET) rate, intracytoplasmic sperm injection

To study the use of intraoperative transvaginal ultrasound after bowel endometriosis shaving. Stepwise demonstration with a narrated video footage of preoperative and intraoperative ultrasound to evaluate the extent of an endometriotic rectal nodule. Lausanne University Hospital and Geneva University Hospital. Two women with symptomatic endometriosis rectal lesion. Preoperative transvaginal ultrasound

To investigate first, the association between endometriosis and preterm birth; second, the associations between endometriosis and preeclampsia, placenta previa, postpartum hemorrhage, stillbirth, and small-for-gestational-age infants (assessed by birthweight); and third, the risk of these adverse pregnancy outcomes with and without the use of medically assisted reproduction. Multicenter retrospective

To describe the intraoperative and postoperative implications arising from the unexpected diagnosis of a Müllerian anomaly during the surgical management of an ectopic pregnancy. Video article. Academic center. A 39-year-old nulligravid woman with anovulation and irregular menstrual cycles presented to the office. Her urine pregnancy test result was incidentally positive; the serum β-human chorionic

To report a rare, misleading fibroid degeneration involving a nonfunctional, noncommunicating horn in a woman with a unicornuate uterus. Although the presence of a functional rudimentary horn may lead to signs and symptoms that recommend its removal, nonfunctional cases are rarely reported, and because of their apparent functional inactivity, the need for their removal has not yet been reported. No

To evaluate the positive predictive value (PPV) of prenatal cell-free DNA (cfDNA) screening for chromosomal aneuploidies in pregnancies achieved either after single euploid transfer in fertilization or Preimplantation Genetic Testing for Aneuploidy (PGT-A) cycles or transfer of single untested embryo, and to assess the concordance of prenatal-cfDNA-screening and PGT-A results. Single center retrospective

To evaluate if in pregnancies conceived with the transfer of single genetically tested embryos, maternal race and ethnicity relate to pregnancy outcome. Retrospective cohort. Data available in the Clinical Outcome Reporting System of the Society for Assisted Reproductive Technology (SART-CORS) for years 2016-2018. Autologous frozen-thaw embryo transfer (FET) cycles with transfer of single genetically

To compare aneuploidy rates among in vitro fertilization (IVF) cycles using preimplantation genetic testing for monogenic disorders (PGT-M) and aneuploidy (PGT-A) compared with IVF cycles using PGT-A alone, and to determine the likelihood of obtaining at least one usable embryo in cycles using PGT-M+PGT-A compared with cycles using PGT-A alone. Retrospective cohort study. Single genetics laboratory

Evidence suggests that aberrant uterine contractility in nonpregnant women with endometriosis and adenomyosis contributes to symptoms and potentially heralds their pathogenesis. However, uterine peristalsis remains understudied, inconsistently measured, and poorly understood. To summarize evidence on uterine contractility across the menstrual cycle phases in women with endometriosis and adenomyosis

To investigate whether operative hysteroscopy in addition to vacuum aspiration for the management of early pregnancy loss effectively increases the success rate of subsequent frozen embryo transfer. Propensity score–matched cohort study. Academic hospital. Women with a miscarriage at 5–16 gestational weeks during an in vitro fertilization cycle in Peking University Third Hospital from 2015 to 2022

To compare the effect of a fully undisturbed culture strategy over a sequential one on embryo in vitro development and clinical outcomes in intracytoplasmic sperm injection (ICSI) cycles. Retrospective cohort study. University-affiliated private IVF center. This study included 4,564 ICSI cycles performed over 5 years, including autologous and oocyte donation treatments with extended embryo culture

To study the effectiveness of a new intrauterine degradable polymer film (Womed Leaf) in the management of moderate to severe intrauterine adhesions (IUA). PREG-2 study was a multicenter, double-blind, randomized, controlled, stratified, two-arm superiority clinical trial conducted in 16 centers in seven countries. Not applicable. Patients ≥18 years scheduled for hysteroscopic adhesiolysis because

To determine whether polycystic ovary syndrome (PCOS) increases adverse pregnancy and birth outcomes in women undergoing frozen embryo transfer (FET). Retrospective cohort study. The PCOS group was matched 1:2 with the control group population using propensity score matching. Not applicable. During an 8-year period, 2,955 patients aged 20–40 years who underwent FET and delivered between January 2015

To demonstrate the anatomical and technical highlights of nerve-sparing deep endometriosis (DE) surgery with rectal discoid resection using a newer single-port robotic system. Step-by-step demonstration of this method was provided with narrated video footage. The surgery was performed at an urban general hospital. Single-port laparoscopic surgery is a useful surgical approach in gynecology because

To evaluate the efficacy and safety of 24-week cyclic administration of estetrol (E4) (15 mg)/drospirenone (DRSP) (3 mg) in Japanese patients with endometriosis. A 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Twenty-five study centers in Japan. A total of 162 Japanese women diagnosed with endometriosis. Participants were randomly allocated to the E4/DRSP

To report utilization, effectiveness, and safety of assisted reproductive technologies in 2015 and 2016. A retrospective, cross-sectional survey of 3,103 assisted reproductive technology clinics in 74 countries in 2015 and 3,249 clinics in 79 countries in 2016 that submitted cycle and pregnancy outcome data through national and regional registries. Seventy-nine countries and >3,000 assisted reproductive

To evaluate the technical accuracy, inheritance, and pathogenicity of small copy number variants (CNVs) detected by a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy (PGT-A) platform. Retrospective observational study performed between 2020 and 2022. Clinic. A total of 12,157 patients who underwent clinical PGT-A performed by targeted next-generation sequencing

Individuals with a disease or treatment that increases their risk of premature gonadal insufficiency may opt to undergo fertility preservation. Those who are postpubertal can often cryopreserve gametes, sperm, or eggs to expand their biologic family using assisted reproductive technologies. Ovarian tissue cryopreservation (OTC) and testicular tissue cryopreservation may be an option for individuals

Advances in the treatment of childhood cancer have significantly improved survival rates, with more than 80% of survivors reaching adulthood. However, gonadotoxic cancer treatments endanger future fertility, and prepubertal males have no option to preserve fertility by sperm cryopreservation. In addition, boys with cryptorchidism are at risk of compromised fertility in adulthood. To investigate current

To describe transvaginal radiofrequency ablation of myomas (TRAM) in 10 key steps. Video article. University hospital. A 38-year-old woman presented with menometrorrhagia and consequent chronic anemia (hemoglobin 8.5 g/dL) caused by a cervical myoma measuring 51 cm. Initially, a cervicovaginal embolization was performed, but without any improvement in symptoms. Given the complex position of the myoma

To examine trends, characteristics, and outcomes of donor oocyte embryo transfer cycles by original oocyte and resultant embryo state and determine whether oocyte state (fresh or frozen) is differentially associated with clinical pregnancy, live birth, and term, healthy birthweight neonates among singleton live births. Retrospective cohort study. National study. Patients undergoing donor oocyte embryo