OBJECTIVE To study sperm parameters recovery and fertility outcomes in men with azoospermia or severe oligospermia caused by anabolic steroid use who underwent a standardized treatment regimen for spermatogenesis recovery. DESIGN AND SUBJECTS: A retrospective analysis of a cohort of men with a prior history of anabolic steroid use and infertility complaints (between 2018 and 2022) was conducted. EXPOSURE

Abstract not available

Objective Surgical demonstration of pre-conceptional laparoscopic repair of chronic myometrial Defect with mesh reinforcement, resulting in successful pregnancy outcome. Design Video case report. The Institutional Ethical Committee was consulted, and the requirement for approval was waived because the video describes a modified surgical technique. The patient included in this video gave consent for

Objective To study the possible role of serum 17α-hydroxy-progesterone (17αOH-P) levels in predicting favorable response to follicle-stimulating hormone (FSH) administration to patients with normal serum FSH levels and idiopathic abnormal sperm parameters. Design Prospective cohort study. Setting University-affiliated fertility center. Subjects 50 patients with oligo-, astheno-, and/or teratozoospermia

Abstract not available

Abstract not available

Abstract not available

Abstract not available

Abstract not available

Abstract not available

Abstract not available

Miscarriage is a relatively common occurrence with many knowns and unknowns and a profound psychological impact on individuals and couples. The editors felt it was time to publish a series of overviews for Views and Reviews on both sporadic miscarriage and recurrent miscarriage. The series starts with prevalence of miscarriage and recurrent miscarriage and subsequently describes the psychological impact

Abstract not available

Abstract not available

Abstract not available

Context and background The prevalence of uterine fibroids is estimated to be approximately 80%. Fibroids can be associated with abnormal uterine bleeding, pressure symptoms, and infertility. Given this high prevalence, approximately 30,000 myomectomies are performed in the United States per year. Minimally invasive approaches are preferred if feasible. The minimally invasive techniques include, laparoscopic

This revised document incorporates a growing number of published studies about mosaic embryo transfer (MET) and provides current evidence-based considerations for the clinical management of embryos with mosaic results on preimplantation genetic testing for aneuploidy (PGT-A). This document replaces the document titled “Clinical management of mosaic results from preimplantation genetic testing for aneuploidy

Abstract not available

Objective (s): The objectives of our study were to investigate the live birth rate (LBR) per oocyte retrieved during IVF, in patients who had used all their embryos and to extrapolate the LBR in patients with remaining frozen embryos by calculating the expected LBR from these embryos. Design A retrospective cohort study Setting A single academically affiliated fertility clinic Patient(s) Autologous

The field of reproductive endocrinology and infertility (REI) is at a crossroads; there is a mismatch between demand for reproductive endocrinology, infertility and assisted reproductive technology (ART) services, and availability of care. This document’s focus is to provide data justifying the critical need for increased provision of fertility services in the United States now and into the future

Abstract not available

Objective To describe the feasibility of Hypothermic Machine Perfusion (HPM) in Uterus Transplantation (UT) to potentially improve the preservation of the uterus to enhance graft preservation in the DBD context. UT is a new surgical approach to treat absolute uterus infertility, it can be performed after living donation (LD) or after Donation after Brainstem Death (DBD). In DBD context, uterus is typically

Abstract not available

Physicians involved in third-party assisted reproductive technology arrangements who discover material misconduct or other undisclosed information by a party to the arrangement (such as a gamete or embryo donor, gestational carrier, or intended parent) or by a nonmedical professional participant or entity (such as a recruiting program, gamete or embryo bank, or lawyer) should encourage that party or

Objective To study the comparison between hysteroscopic morcellation of retained products of conception with ultrasound guided electric vacuum aspiration in terms of intrauterine adhesion formation, as well as efficacy and complications. Design Randomized controlled, non-blinded trial conducted in three teaching hospitals and one university hospital from April 2015 to June 2022. Subjects One-hundred

Abstract not available

Abstract not available

Sexually transmitted infections are of major concern to reproductive specialists. Heading the list are human immunodeficiency virus types 1 and 2 and hepatitis B and C viruses. These pathogens, which may cause incurable chronic infections, can be transmitted through assisted reproductive technologies and from infected mothers to the fetus or newborn. This document replaces the document of the same

Objective To determine whether peak estradiol (E2) levels above the usual physiologic range (300-500 pg/mL) will impact programmed frozen embryo transfer (FET) outcomes in an ideal study population of those using good-quality single euploid blastocysts. Design Retrospective cohort study Subjects Single euploid programmed FET done at a single academic institution from January 2016 to December 2019.

Approximately 80% of miscarriages happen within the first 12 weeks of gestation. More than half of early losses result from genetic defects, usually presenting as abnormal chromosome numbers or gene rearrangements in the embryo. However, the impact of genetics upon pregnancy loss goes well beyond embryonic aneuploidy. For example, the use of big data has recently led to the discovery of specific gene

Miscarriage and recurrent miscarriage affect a significant proportion of every population with research consistently showing it results in profound and often prolonged psychological impacts. Despite the serious psychological impacts, support for miscarriage remains grossly inadequate. There are many ways to ameliorate the impact of these losses, which are not difficult, expensive or time-consuming

Abstract not available

The physical and psychological impact of miscarriage can be devastating. There are many lifestyle and therapeutic interventions that may prevent a miscarriage. In this review we have outlined the key areas for health optimization to prevent pregnancy loss, drawing on the available up-to-date evidence. The three key areas identified are lifestyle optimization in females, lifestyle optimization in males

This narrative review summarizes the current knowledge on the role of uterine Natural Killer cells in recurrent pregnancy loss and possible treatment options. Recurrent Pregnancy Loss (RPL) involves two or more consecutive miscarriages, affecting around 3% of couples attempting conception. Despite extensive investigation, causes often remain elusive. Uterine Natural Killer (uNK) cells, critical in

Abstract not available

Abstract not available

Infections with certain pathogens can lead to perinatal complications. Several infections have also been associated with an increased likelihood of a miscarriage. This manuscript discusses these infections, their modes of transmission, the evidence linking them to an increased risk of miscarriage, and whether prevention or treatment strategies are available.

Abstract not available

Abstract not available

Abstract not available

Abstract not available

Abstract not available

Abstract not available

STUDY QUESTION What is the recommended assessment and management of those with polycystic ovary syndrome (PCOS), based on the best available evidence, clinical expertise, and consumer preference? SUMMARY ANSWER International evidence-based guidelines address prioritized questions and outcomes and include 254 recommendations and practice points, to promote consistent, evidence-based care and improve

Abstract not available

OBJECTIVE To determine how often a non-euploid result from a single trophectoderm biopsy tested with next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) is concordant with rebiopsies tested with a single nucleotide polymorphism (SNP) array-based PGT-A platform. DESIGN Blinded prospective cohort study. SETTING University-affiliated fertility center. PATIENT(s)

Abstract not available

Abstract not available

Current clinical evaluation of male factors poorly predicts assisted reproductive technology outcome. Sperm DNA fragmentation is useful. More advanced analysis of sperm structure and genetics could better assess male reproductive competence.

Abstract not available

Objective To describe a novel high-precision technique for robotic excision of uterine isthmocele, employing a carbon dioxide laser fiber, under hysteroscopic guidance, and near-infrared guidance. Design Video article. Subject(s) A 36-year-old multipara with three prior cesarean sections presented to our infertility clinic with secondary infertility. The patient had been trying to conceive for 6 months

Importance Genetic testing of gamete donors is becoming increasingly comprehensive and now often includes expanded carrier screening. Some argue that testing has gone too far, while others propose that testing is not extensive enough. Thinking critically about how much genetic testing is appropriate for gamete donors is crucial for ensuring that market forces alone do not determine the level of testing

Objective To assess if high BMI in either oocyte donors or recipients is associated with poorer outcomes after first single blastocyst transfers. Design Retrospective study including 1394 first blastocyst single embryo transfers (SETs) conducted by 1394 recipients during oocyte donation cycles with the gametes retrieved from 1394 women (Jan2019-July2021). Four BMI clusters were defined for both donors

Objective To determine if ovarian responsiveness to gonadotropin stimulation differs by race/ethnicity and whether this predicts live birth rates (LBRs) in non-White patients undergoing in vitro fertilization (IVF) Design Retrospective cohort study Subjects White, Asian, Black, and Hispanic patients undergoing ovarian stimulation for IVF at an academic infertility clinic Exposure Self-reported race

Objective Which girls with Turner syndrome (TS) could benefit from fertility preservation by ovarian tissue cryopreservation (OTC) based on karyotype, puberty status and hormonal data? Design Prospective intervention study. Participants were included between 2018 and 2020. Subjects In total, 106 girls with TS, aged between 2 and 18 years were included. Girls with minor X chromosome deletions, Y chromosomal

Objective To evaluate the association of body mass index (BMI) with cycle outcomes after euploid frozen blastocyst transfer. Design Retrospective cohort study. Setting Not applicable. Patient(s) A total of 56,564 first single autologous euploid frozen embryo transfers (FET) from the 2016-2019 Society for Assisted Reproductive Technology database were analyzed by BMI and by World Health Organization

Abstract not available

Abstract not available

Abstract not available

Objective To determine whether TOP5300, a novel oral follicle stimulating hormone receptor (FSHR) allosteric agonist, elicits a different cellular response than recombinant human FSH (rh-FSH) in human granulosa cells from in vitro fertilization patients. Design Basic science research with a preclinical allosteric FSHR agonist. Subjects Infertility patients at a single academic fertility clinic were