-
An Asymmetric sp3–sp3 Cross-Electrophile Coupling Using ‘Ene’-Reductases Nature (IF 69.504) Pub Date : 2022-08-11 Haigen Fu, Jingzhe Cao, Tianzhang Qiao, Yuyin Qi, Simon J. Charnock, Samuel Garfinkle, Todd K. Hyster
The catalytic asymmetric construction of Csp3–Csp3 bonds remains one of the foremost challenges in organic synthesis.1 Metal-catalyzed cross-electrophile couplings (XEC) have emerged as a powerful tool for C–C bond formation.2-5 However, coupling two distinct Csp3-electrophiles with high cross- and stereoselectivity continues as an unmet challenge. Here, we report a highly chemo- and enantioselective
-
Pandemic-Scale Phylogenomics Reveals The SARS-CoV-2 Recombination Landscape Nature (IF 69.504) Pub Date : 2022-08-11 Yatish Turakhia, Bryan Thornlow, Angie Hinrichs, Jakob McBroome, Nicolas Ayala, Cheng Ye, Kyle Smith, Nicola De Maio, David Haussler, Robert Lanfear, Russell Corbett-Detig
Accurate and timely detection of recombinant lineages is crucial for interpreting genetic variation, reconstructing epidemic spread, identifying selection and variants of interest, and accurately performing phylogenetic analyses 1–4. During the SARS-CoV-2 pandemic, genomic data generation has exceeded the capacities of existing analysis platforms, thereby crippling real-time analysis of viral evolution
-
Context-specific emergence and growth of the SARS-CoV-2 Delta variant Nature (IF 69.504) Pub Date : 2022-08-11 John T. McCrone, Verity Hill, Sumali Bajaj, Rosario Evans Pena, Ben C. Lambert, Rhys Inward, Samir Bhatt, Erik Volz, Christopher Ruis, Simon Dellicour, Guy Baele, Alexander E. Zarebski, Adam Sadilek, Neo Wu, Aaron Schneider, Xiang Ji, Jayna Raghwani, Ben Jackson, Rachel Colquhoun, Áine O’Toole, Thomas P. Peacock, Kate Twohig, Simon Thelwall, Gavin Dabrera, Richard Myers, Nuno R. Faria, Carmen Huber
The SARS-CoV-2 Delta variant of concern spread globally, causing resurgences of COVID-19 worldwide1,2. Delta’s emergence in the UK occurred on the background of a heterogeneous landscape of immunity and relaxation of non-pharmaceutical interventions. Here we analyse 52,992 virus genomes from England together with 93,649 global genomes to reconstruct the emergence of Delta, and quantify its introduction
-
Quantum cascade of correlated phases in trigonally warped bilayer graphene Nature (IF 69.504) Pub Date : 2022-08-10 Anna M. Seiler, Fabian R. Geisenhof, Felix Winterer, Kenji Watanabe, Takashi Taniguchi, Tianyi Xu, Fan Zhang, R. Thomas Weitz
-
Sufficient conditions for rapid range expansion of a boreal conifer Nature (IF 69.504) Pub Date : 2022-08-10 Roman J. Dial, Colin T. Maher, Rebecca E. Hewitt, Patrick F. Sullivan
-
4-bit adhesion logic enables universal multicellular interface patterning Nature (IF 69.504) Pub Date : 2022-08-10 Honesty Kim, Dominic J. Skinner, David S. Glass, Alexander E. Hamby, Bradey A. R. Stuart, Jörn Dunkel, Ingmar H. Riedel-Kruse
-
Giant impacts and the origin and evolution of continents Nature (IF 69.504) Pub Date : 2022-08-10 Tim E. Johnson, Christopher L. Kirkland, Yongjun Lu, R. Hugh Smithies, Michael Brown, Michael I. H. Hartnady
-
Spatial multi-omic map of human myocardial infarction Nature (IF 69.504) Pub Date : 2022-08-10 Christoph Kuppe, Ricardo O. Ramirez Flores, Zhijian Li, Sikander Hayat, Rebecca T. Levinson, Xian Liao, Monica T. Hannani, Jovan Tanevski, Florian Wünnemann, James S. Nagai, Maurice Halder, David Schumacher, Sylvia Menzel, Gideon Schäfer, Konrad Hoeft, Mingbo Cheng, Susanne Ziegler, Xiaoting Zhang, Fabian Peisker, Nadine Kaesler, Turgay Saritas, Yaoxian Xu, Astrid Kassner, Jan Gummert, Michiel Morshuis
-
Antarctic calving loss rivals ice-shelf thinning Nature (IF 69.504) Pub Date : 2022-08-10 Chad A. Greene, Alex S. Gardner, Nicole-Jeanne Schlegel, Alexander D. Fraser
-
A mechanically strong and ductile soft magnet with extremely low coercivity Nature (IF 69.504) Pub Date : 2022-08-10 Liuliu Han, Fernando Maccari, Isnaldi R. Souza Filho, Nicolas J. Peter, Ye Wei, Baptiste Gault, Oliver Gutfleisch, Zhiming Li, Dierk Raabe
-
Diverse mutational landscapes in human lymphocytes Nature (IF 69.504) Pub Date : 2022-08-10 Heather E. Machado, Emily Mitchell, Nina F. Øbro, Kirsten Kübler, Megan Davies, Daniel Leongamornlert, Alyssa Cull, Francesco Maura, Mathijs A. Sanders, Alex T. J. Cagan, Craig McDonald, Miriam Belmonte, Mairi S. Shepherd, Felipe A. Vieira Braga, Robert J. Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R. Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J. Hodson, David
-
A monocyte–leptin–angiogenesis pathway critical for repair post-infection Nature (IF 69.504) Pub Date : 2022-08-10 Rachel M. Kratofil, Hanjoo B. Shim, Raymond Shim, Woo Yong Lee, Elodie Labit, Sarthak Sinha, Catherine M. Keenan, Bas G. J. Surewaard, Ji Yeon Noh, Yuxiang Sun, Keith A. Sharkey, Matthias Mack, Jeff Biernaskie, Justin F. Deniset, Paul Kubes
-
Perovskite superlattices with efficient carrier dynamics Nature (IF 69.504) Pub Date : 2022-08-10 Yusheng Lei, Yuheng Li, Chengchangfeng Lu, Qizhang Yan, Yilei Wu, Finn Babbe, Huaxin Gong, Song Zhang, Jiayun Zhou, Ruotao Wang, Ruiqi Zhang, Yimu Chen, Hsinhan Tsai, Yue Gu, Hongjie Hu, Yu-Hwa Lo, Wanyi Nie, Taeyoon Lee, Jian Luo, Kesong Yang, Kyung-In Jang, Sheng Xu
-
Spatially resolved clonal copy number alterations in benign and malignant tissue Nature (IF 69.504) Pub Date : 2022-08-10 Andrew Erickson, Mengxiao He, Emelie Berglund, Maja Marklund, Reza Mirzazadeh, Niklas Schultz, Linda Kvastad, Alma Andersson, Ludvig Bergenstråhle, Joseph Bergenstråhle, Ludvig Larsson, Leire Alonso Galicia, Alia Shamikh, Elisa Basmaci, Teresita Díaz De Ståhl, Timothy Rajakumar, Dimitrios Doultsinos, Kim Thrane, Andrew L. Ji, Paul A. Khavari, Firaz Tarish, Anna Tanoglidi, Jonas Maaskola, Richard Colling
-
Pyramidal neuron subtype diversity governs microglia states in the neocortex Nature (IF 69.504) Pub Date : 2022-08-10 Jeffrey A. Stogsdill, Kwanho Kim, Loïc Binan, Samouil L. Farhi, Joshua Z. Levin, Paola Arlotta
-
Cyclic nucleotide-induced helical structure activates a TIR immune effector Nature (IF 69.504) Pub Date : 2022-08-10 Gaëlle Hogrel, Abbie Guild, Shirley Graham, Hannah Rickman, Sabine Grüschow, Quentin Bertrand, Laura Spagnolo, Malcolm F. White
-
Self-emergence of robust solitons in a microcavity Nature (IF 69.504) Pub Date : 2022-08-10 Maxwell Rowley, Pierre-Henry Hanzard, Antonio Cutrona, Hualong Bao, Sai T. Chu, Brent E. Little, Roberto Morandotti, David J. Moss, Gian-Luca Oppo, Juan Sebastian Totero Gongora, Marco Peccianti, Alessia Pasquazi
-
Truncated FGFR2 is a clinically actionable oncogene in multiple cancers Nature (IF 69.504) Pub Date : 2022-08-10 Daniel Zingg, Jinhyuk Bhin, Julia Yemelyanenko, Sjors M. Kas, Frank Rolfs, Catrin Lutz, Jessica K. Lee, Sjoerd Klarenbeek, Ian M. Silverman, Stefano Annunziato, Chang S. Chan, Sander R. Piersma, Timo Eijkman, Madelon Badoux, Ewa Gogola, Bjørn Siteur, Justin Sprengers, Bim de Klein, Richard R. de Goeij-de Haas, Gregory M. Riedlinger, Hua Ke, Russell Madison, Anne Paulien Drenth, Eline van der Burg,
-
Direct evidence for phosphorus limitation on Amazon forest productivity Nature (IF 69.504) Pub Date : 2022-08-10 Hellen Fernanda Viana Cunha, Kelly M. Andersen, Laynara Figueiredo Lugli, Flavia Delgado Santana, Izabela Fonseca Aleixo, Anna Martins Moraes, Sabrina Garcia, Raffaello Di Ponzio, Erick Oblitas Mendoza, Bárbara Brum, Jéssica Schmeisk Rosa, Amanda L. Cordeiro, Bruno Takeshi Tanaka Portela, Gyovanni Ribeiro, Sara Deambrozi Coelho, Sheila Trierveiler de Souza, Lara Siebert Silva, Felipe Antonieto, Maria
-
Experimental demonstration of optical stochastic cooling Nature (IF 69.504) Pub Date : 2022-08-10 J. Jarvis, V. Lebedev, A. Romanov, D. Broemmelsiek, K. Carlson, S. Chattopadhyay, A. Dick, D. Edstrom, I. Lobach, S. Nagaitsev, H. Piekarz, P. Piot, J. Ruan, J. Santucci, G. Stancari, A. Valishev
-
The retroelement Lx9 puts a brake on the immune response to virus infection Nature (IF 69.504) Pub Date : 2022-08-10 Nenad Bartonicek, Romain Rouet, Joanna Warren, Claudia Loetsch, Gabriela Santos Rodriguez, Stacey Walters, Francis Lin, David Zahra, James Blackburn, Jillian M. Hammond, Andre L. M. Reis, Ira W. Deveson, Nathan Zammit, Mahdi Zeraati, Shane Grey, Daniel Christ, John S. Mattick, Tatyana Chtanova, Robert Brink, Marcel E. Dinger, Robert J. Weatheritt, Jonathan Sprent, Cecile King
-
Warm springs alter timing but not total growth of temperate deciduous trees Nature (IF 69.504) Pub Date : 2022-08-10 Cameron Dow, Albert Y. Kim, Loïc D’Orangeville, Erika B. Gonzalez-Akre, Ryan Helcoski, Valentine Herrmann, Grant L. Harley, Justin T. Maxwell, Ian R. McGregor, William J. McShea, Sean M. McMahon, Neil Pederson, Alan J. Tepley, Kristina J. Anderson-Teixeira
-
Realizing a 1D topological gauge theory in an optically dressed BEC Nature (IF 69.504) Pub Date : 2022-08-10 Anika Frölian, Craig S. Chisholm, Elettra Neri, Cesar R. Cabrera, Ramón Ramos, Alessio Celi, Leticia Tarruell
-
Even modest climate change may lead to major transitions in boreal forests Nature (IF 69.504) Pub Date : 2022-08-10 Peter B. Reich, Raimundo Bermudez, Rebecca A. Montgomery, Roy L. Rich, Karen E. Rice, Sarah E. Hobbie, Artur Stefanski
-
Response of the East Antarctic Ice Sheet to past and future climate change Nature (IF 69.504) Pub Date : 2022-08-10 Chris R. Stokes, Nerilie J. Abram, Michael J. Bentley, Tamsin L. Edwards, Matthew H. England, Annie Foppert, Stewart S. R. Jamieson, Richard S. Jones, Matt A. King, Jan T. M. Lenaerts, Brooke Medley, Bertie W. J. Miles, Guy J. G. Paxman, Catherine Ritz, Tina van de Flierdt, Pippa L. Whitehouse
-
Molecular Editing of Aza-arene C–H Bonds by Distance, Geometry and Chirality Nature (IF 69.504) Pub Date : 2022-08-09 Zhoulong Fan, Xiangyang Chen, Keita Tanaka, Han Seul Park, Nelson Y. S. Lam, Jonathan J. Wong, K. N. Houk, Jin-Quan Yu
Direct molecular editing of heteroarene carbon-hydrogen (C–H) bonds through consecutive selective C–H functionalization has the potential to grant rapid access into diverse chemical space; a valuable but often challenging venture to achieve in medicinal chemistry1. Contrasting with electronically-biased heterocyclic C–H bonds2-9, remote benzocyclic C–H bonds on bicyclic aza-arenes are especially difficult
-
The mechanism of RNA capping by SARS-CoV-2 Nature (IF 69.504) Pub Date : 2022-08-09 Gina J. Park, Adam Osinski, Genaro Hernandez, Jennifer L. Eitson, Abir Majumdar, Marco Tonelli, Katie Henzler-Wildman, Krzysztof Pawłowski, Zhe Chen, Yang Li, John W. Schoggins, Vincent S. Tagliabracci
The SARS-CoV-2 RNA genome contains a 5′-cap that facilitates translation of viral proteins, protection from exonucleases and evasion of the host immune response1-4. How this cap is made in SARS-CoV-2 is not completely understood. Here, we reconstitute the SARS-CoV-2 7MeGpppA2′-O-Me-RNA cap using virally encoded non-structural proteins (nsps). We show that the kinase-like NiRAN domain5 of nsp12 transfers
-
Autoantibody mimicry of hormone action at the thyrotropin receptor Nature (IF 69.504) Pub Date : 2022-08-08 Bryan Faust, Christian B. Billesbølle, Carl-Mikael Suomivuori, Isha Singh, Kaihua Zhang, Nicholas Hoppe, Antonio F. M. Pinto, Jolene K. Diedrich, Yagmur Muftuoglu, Mariusz W. Szkudlinski, Alan Saghatelian, Ron O. Dror, Yifan Cheng, Aashish Manglik
Thyroid hormones are vital to metabolism, growth and development1. Thyroid hormone synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR)2. Autoantibodies that activate the TSHR pathologically increase thyroid hormones in Graves’ disease3. How autoantibodies mimic TSH function remains unclear. We determined cryogenic-electron microscopy structures of active and
-
Diverse Tsunamigenesis Triggered by the Hunga Tonga-Hunga Ha’apai Eruption Nature (IF 69.504) Pub Date : 2022-08-08 Patrick Lynett, Maile McCann, Zili Zhou, Willington Renteria, Jose Borrero, Dougal Greer, Ofa Fa’anunu, Cyprien Bosserelle, Bruce Jaffe, SeanPaul La Selle, Andrew Ritchie, Alexander Snyder, Brandon Nasr, Jacqueline Bott, Nicholas Graehl, Costas Synolakis, Behzad Ebrahimi, Gizem Ezgi Cinar
On the evening of 15 January 2022, the Hunga Tonga-Hunga Ha’apai volcano1 unleashed a violent underwater eruption, blanketing the surrounding land masses in ash and debris2, 3. The eruption generated tsunamis observed around the world. An event of this type last occurred in 1883 during the eruption of Krakatau4, and thus we have the first observations of a tsunami from a large emergent volcanic eruption
-
Hormone- and antibody-mediated activation of the thyrotropin receptor Nature (IF 69.504) Pub Date : 2022-08-08 Jia Duan, Peiyu Xu, Xiaodong Luan, Yujie Ji, Xinheng He, Ning Song, Qingning Yuan, Ye Jin, Xi Cheng, Hualiang Jiang, Jie Zheng, Shuyang Zhang, Yi Jiang, H. Eric Xu
Thyroid stimulating hormone (TSH), through activation of its G protein-coupled thyrotropin receptor (TSHR), controls the synthesis of thyroid hormone (TH), an essential metabolic hormone1-3. Aberrant signaling of TSHR by autoantibodies causes Graves’ disease and hypothyroidism that affect millions of patients worldwide4. Here we report the active structures of TSHR with TSH and an activating autoantibody
-
DOCK2 is involved in the host genetics and biology of severe COVID-19 Nature (IF 69.504) Pub Date : 2022-08-08 Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee, Takanori Hasegawa, Koji Okudela, Daisuke Okuzaki, Daisuke Motooka, Masahiro Kanai, Tatsuhiko Naito, Kenichi Yamamoto, Qingbo S. Wang, Ryunosuke Saiki, Rino Ishihara, Yuta Matsubara, Junko Hamamoto, Hiroyuki Hayashi, Yukihiro Yoshimura, Natsuo Tachikawa, Emmy
Identifying the factors underlying severe COVID-19 in the host genetics is an emerging issue1–5. We conducted a genome-wide association study (GWAS) involving 2,393 Japanese COVID-19 cases collected in initial pandemic waves with 3,289 controls, which identified a variant on 5q35 (rs60200309-A) near DOCK2 associated with severe COVID-19 in younger (<65 ages) patients (nCase=440, odds ratio=2.01, P=1
-
Cellular recovery after prolonged warm ischaemia of the whole body Nature (IF 69.504) Pub Date : 2022-08-03 David Andrijevic, Zvonimir Vrselja, Taras Lysyy, Shupei Zhang, Mario Skarica, Ana Spajic, David Dellal, Stephanie L. Thorn, Robert B. Duckrow, Shaojie Ma, Phan Q. Duy, Atagun U. Isiktas, Dan Liang, Mingfeng Li, Suel-Kee Kim, Stefano G. Daniele, Khadija Banu, Sudhir Perincheri, Madhav C. Menon, Anita Huttner, Kevin N. Sheth, Kevin T. Gobeske, Gregory T. Tietjen, Hitten P. Zaveri, Stephen R. Latham,
-
The challenge of unprecedented floods and droughts in risk management Nature (IF 69.504) Pub Date : 2022-08-03 Heidi Kreibich, Anne F. Van Loon, Kai Schröter, Philip J. Ward, Maurizio Mazzoleni, Nivedita Sairam, Guta Wakbulcho Abeshu, Svetlana Agafonova, Amir AghaKouchak, Hafzullah Aksoy, Camila Alvarez-Garreton, Blanca Aznar, Laila Balkhi, Marlies H. Barendrecht, Sylvain Biancamaria, Liduin Bos-Burgering, Chris Bradley, Yus Budiyono, Wouter Buytaert, Lucinda Capewell, Hayley Carlson, Yonca Cavus, Anaïs Couasnon
-
Coronaviruses exploit a host cysteine-aspartic protease for replication Nature (IF 69.504) Pub Date : 2022-08-03 Hin Chu, Yuxin Hou, Dong Yang, Lei Wen, Huiping Shuai, Chaemin Yoon, Jialu Shi, Yue Chai, Terrence Tsz-Tai Yuen, Bingjie Hu, Cun Li, Xiaoyu Zhao, Yixin Wang, Xiner Huang, Kin Shing Lee, Luo Cuiting, Jian-Piao Cai, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Anna Jinxia Zhang, Shuofeng Yuan, Ko-Yung Sit, Dominic Chi-Chung Foo, Wing-Kuk Au, Kenneth Kak-Yuen Wong, Jie Zhou, Kin-Hang Kok, Dong-Yan Jin
Highly pathogenic coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1,2, Middle East respiratory syndrome coronavirus (MERS-CoV)3, and SARS-CoV-14 vary in their transmissibility and pathogenicity. However, infection by all three viruses results in substantial apoptosis in cell culture5-7 and in patient tissues8-10, suggesting a potential link between apoptosis and
-
A non-canonical vitamin K cycle is a potent ferroptosis suppressor Nature (IF 69.504) Pub Date : 2022-08-03 Eikan Mishima, Junya Ito, Zijun Wu, Toshitaka Nakamura, Adam Wahida, Sebastian Doll, Wulf Tonnus, Palina Nepachalovich, Elke Eggenhofer, Maceler Aldrovandi, Bernhard Henkelmann, Ken-ichi Yamada, Jonas Wanninger, Omkar Zilka, Emiko Sato, Regina Feederle, Daniela Hass, Adriano Maida, André Santos Dias Mourão, Andreas Linkermann, Edward K. Geissler, Kiyotaka Nakagawa, Takaaki Abe, Maria Fedorova, Bettina
-
A mitotic chromatin phase transition prevents perforation by microtubules Nature (IF 69.504) Pub Date : 2022-08-03 Maximilian W. G. Schneider, Bryan A. Gibson, Shotaro Otsuka, Maximilian F. D. Spicer, Mina Petrovic, Claudia Blaukopf, Christoph C. H. Langer, Paul Batty, Thejaswi Nagaraju, Lynda K. Doolittle, Michael K. Rosen, Daniel W. Gerlich
-
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion Nature (IF 69.504) Pub Date : 2022-08-03 Ju-Qiong Wang, Liang-Liang Li, Ao Hu, Gang Deng, Jian Wei, Yun-Feng Li, Yuan-Bin Liu, Xiao-Yi Lu, Zhi-Ping Qiu, Xiong-Jie Shi, Xiaolu Zhao, Jie Luo, Bao-Liang Song
-
Architecture and self-assembly of the jumbo bacteriophage nuclear shell Nature (IF 69.504) Pub Date : 2022-08-03 Thomas G. Laughlin, Amar Deep, Amy M. Prichard, Christian Seitz, Yajie Gu, Eray Enustun, Sergey Suslov, Kanika Khanna, Erica A. Birkholz, Emily Armbruster, J. Andrew McCammon, Rommie E. Amaro, Joe Pogliano, Kevin D. Corbett, Elizabeth Villa
-
Pulsed hydraulic-pressure-responsive self-cleaning membrane Nature (IF 69.504) Pub Date : 2022-08-03 Yang Zhao, Yuna Gu, Bin Liu, Yujie Yan, Chao Shan, Jian Guo, Shantao Zhang, Chad D. Vecitis, Guandao Gao
-
A physical wiring diagram for the human immune system Nature (IF 69.504) Pub Date : 2022-08-03 Jarrod Shilts, Yannik Severin, Francis Galaway, Nicole Müller-Sienerth, Zheng-Shan Chong, Sophie Pritchard, Sarah Teichmann, Roser Vento-Tormo, Berend Snijder, Gavin J. Wright
-
Brown-fat-mediated tumour suppression by cold-altered global metabolism Nature (IF 69.504) Pub Date : 2022-08-03 Takahiro Seki, Yunlong Yang, Xiaoting Sun, Sharon Lim, Sisi Xie, Ziheng Guo, Wenjing Xiong, Masashi Kuroda, Hiroshi Sakaue, Kayoko Hosaka, Xu Jing, Masahito Yoshihara, Lili Qu, Xin Li, Yuguo Chen, Yihai Cao
-
Strong yet ductile nanolamellar high-entropy alloys by additive manufacturing Nature (IF 69.504) Pub Date : 2022-08-03 Jie Ren, Yin Zhang, Dexin Zhao, Yan Chen, Shuai Guan, Yanfang Liu, Liang Liu, Siyuan Peng, Fanyue Kong, Jonathan D. Poplawsky, Guanhui Gao, Thomas Voisin, Ke An, Y. Morris Wang, Kelvin Y. Xie, Ting Zhu, Wen Chen
-
Transcriptome variation in human tissues revealed by long-read sequencing Nature (IF 69.504) Pub Date : 2022-08-03 Dafni A. Glinos, Garrett Garborcauskas, Paul Hoffman, Nava Ehsan, Lihua Jiang, Alper Gokden, Xiaoguang Dai, François Aguet, Kathleen L. Brown, Kiran Garimella, Tera Bowers, Maura Costello, Kristin Ardlie, Ruiqi Jian, Nathan R. Tucker, Patrick T. Ellinor, Eoghan D. Harrington, Hua Tang, Michael Snyder, Sissel Juul, Pejman Mohammadi, Daniel G. MacArthur, Tuuli Lappalainen, Beryl B. Cummings
-
Highly efficient blue InGaN nanoscale light-emitting diodes Nature (IF 69.504) Pub Date : 2022-08-03 Mihyang Sheen, Yunhyuk Ko, Dong-uk Kim, Jongil Kim, Jin-ho Byun, YongSeok Choi, Jonghoon Ha, Ki Young Yeon, Dohyung Kim, Jungwoon Jung, Jinyoung Choi, Ran Kim, Jewon Yoo, Inpyo Kim, Chanwoo Joo, Nami Hong, Joohee Lee, Sang Ho Jeon, Sang Ho Oh, Jaekwang Lee, Nari Ahn, Changhee Lee
-
Timescales for pluton growth, magma-chamber formation and super-eruptions Nature (IF 69.504) Pub Date : 2022-08-03 M. E. van Zalinge, D. F. Mark, R. S. J. Sparks, M. M. Tremblay, C. B. Keller, F. J. Cooper, A. Rust
-
Non-Hermitian morphing of topological modes Nature (IF 69.504) Pub Date : 2022-08-03 Wei Wang, Xulong Wang, Guancong Ma
-
Teixobactin kills bacteria by a two-pronged attack on the cell envelope Nature (IF 69.504) Pub Date : 2022-08-03 Rhythm Shukla, Francesca Lavore, Sourav Maity, Maik G. N. Derks, Chelsea R. Jones, Bram J. A. Vermeulen, Adéla Melcrová, Michael A. Morris, Lea Marie Becker, Xiaoqi Wang, Raj Kumar, João Medeiros-Silva, Roy A. M. van Beekveld, Alexandre M. J. J. Bonvin, Joseph H. Lorent, Moreno Lelli, James S. Nowick, Harold D. MacGillavry, Aaron J. Peoples, Amy L. Spoering, Losee L. Ling, Dallas E. Hughes, Wouter
-
Modular strategy for development of the hierarchical visual network in mice Nature (IF 69.504) Pub Date : 2022-08-03 Tomonari Murakami, Teppei Matsui, Masato Uemura, Kenichi Ohki
-
RNA editing underlies genetic risk of common inflammatory diseases Nature (IF 69.504) Pub Date : 2022-08-03 Qin Li, Michael J. Gloudemans, Jonathan M. Geisinger, Boming Fan, François Aguet, Tao Sun, Gokul Ramaswami, Yang I. Li, Jin-Biao Ma, Jonathan K. Pritchard, Stephen B. Montgomery, Jin Billy Li
-
Transformations of neural representations in a social behaviour network Nature (IF 69.504) Pub Date : 2022-08-03 Bin Yang, Tomomi Karigo, David J. Anderson
-
Structural insights into auxin recognition and efflux by Arabidopsis PIN1 Nature (IF 69.504) Pub Date : 2022-08-02 Zhisen Yang, Jing Xia, Jingjing Hong, Chenxi Zhang, Hong Wei, Wei Ying, Chunqiao Sun, Lianghanxiao Sun, Yanbo Mao, Yongxiang Gao, Shutang Tan, Jiří Friml, Dianfan Li, Xin Liu, Linfeng Sun
Polar auxin transport (PAT) is unique to plants and coordinates their growth and development1,2. The PIN-FORMED (PIN) auxin transporters with remarkable asymmetrical localizations at the plasma membrane drive PAT3,4, however, their structures and transport mechanisms remain largely unknown. Here, we report three inward-facing conformation structures of the major member of the PIN family, PIN1 in Arabidopsis
-
Structures and mechanisms of the Arabidopsis auxin transporter PIN3 Nature (IF 69.504) Pub Date : 2022-08-02 Nannan Su, Aiqin Zhu, Xin Tao, Zhong Jie Ding, Shenghai Chang, Fan Ye, Yan Zhang, Cheng Zhao, Qian Chen, Jiangqin Wang, Chen Yu Zhou, Yirong Guo, Shasha Jiao, Sufen Zhang, Han Wen, Lixin Ma, Sheng Ye, Shao Jian Zheng, Fan Yang, Shan Wu, Jiangtao Guo
The PIN-FORMED (PIN) protein family of auxin transporters mediates the polar auxin transport and plays crucial roles in plant growth and development1,2. Here we present cryo-EM structures of PIN3 from Arabidopsis thaliana (AtPIN3) in the apo state and in complex with its substrate indole-3-acetic acid (IAA) and the inhibitor N-1-naphthylphthalamic acid (NPA) at 2.6–3.0 Å resolution. AtPIN3 exists as
-
P-type electrical contacts for two-dimensional transition metal dichalcogenides Nature (IF 69.504) Pub Date : 2022-08-01 Yan Wang, Jong Chan Kim, Yang Li, Kyung Yeol Ma, Seokmo Hong, Minsu Kim, Hyeon Suk Shin, Hu Young Jeong, Manish Chhowalla
Digital logic circuits are based on complementary pairs of n- and p-type field effect transistors (FETs) via complementary metal oxide semiconductor (CMOS) technology. In three dimensional (3D or bulk) semiconductors, substitutional doping of acceptor or donor impurities is used to achieve p- and n-type FETs. However, the controllable p-type doping of low-dimensional semiconductors such as two-dimensional
-
Social capital I: measurement and associations with economic mobility Nature (IF 69.504) Pub Date : 2022-08-01 Raj Chetty, Matthew O. Jackson, Theresa Kuchler, Johannes Stroebel, Nathaniel Hendren, Robert B. Fluegge, Sara Gong, Federico Gonzalez, Armelle Grondin, Matthew Jacob, Drew Johnston, Martin Koenen, Eduardo Laguna-Muggenburg, Florian Mudekereza, Tom Rutter, Nicolaj Thor, Wilbur Townsend, Ruby Zhang, Mike Bailey, Pablo Barberá, Monica Bhole, Nils Wernerfelt
-
Social capital II: determinants of economic connectedness Nature (IF 69.504) Pub Date : 2022-08-01 Raj Chetty, Matthew O. Jackson, Theresa Kuchler, Johannes Stroebel, Nathaniel Hendren, Robert B. Fluegge, Sara Gong, Federico Gonzalez, Armelle Grondin, Matthew Jacob, Drew Johnston, Martin Koenen, Eduardo Laguna-Muggenburg, Florian Mudekereza, Tom Rutter, Nicolaj Thor, Wilbur Townsend, Ruby Zhang, Mike Bailey, Pablo Barberá, Monica Bhole, Nils Wernerfelt
-
Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19 Nature (IF 69.504) Pub Date : 2022-07-28 Fotios Karagiannis, Konrad Peukert, Laura Surace, Marcel Michla, Fabian Nikolka, Mario Fox, Patricia Weiss, Caroline Feuerborn, Paul Maier, Susanne Schulz, Burcu Al, Benjamin Seeliger, Tobias Welte, Sascha David, Inge Grondman, Aline H. de Nooijer, Peter Pickkers, Jan Lukas Kleiner, Marc Moritz Berger, Thorsten Brenner, Christian Putensen, Hiroki Kato, Natalio Garbi, Mihai G. Netea, Karsten Hiller
Anorexia and fasting are host adaptations to acute infection, inducing a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB) 1-6. However, whether ketogenesis metabolically influences the immune response in pulmonary infections remains unclear. Here we report impaired production of BHB in humans with SARS-CoV-2-induced but not influenza-induced
-
Tracking single adatoms in liquid in a Transmission Electron Microscope Nature (IF 69.504) Pub Date : 2022-07-27 Nick Clark, Daniel J. Kelly, Mingwei Zhou, Yi-Chao Zou, Chang Woo Myung, David G. Hopkinson, Christoph Schran, Angelos Michaelides, Roman Gorbachev, Sarah J. Haigh
Single atoms or ions on surfaces affect processes from nucleation1 to electrochemical reactions2 and heterogeneous catalysis3. Transmission electron microscopy (TEM) is a leading approach for visualizing single atoms on a variety of substrates4,5. It conventionally requires high vacuum conditions, but has been developed for in situ imaging in liquid and gaseous environments6,7 with a combined spatial
-
Dislocation-induced stop-and-go kinetics of interfacial transformations Nature (IF 69.504) Pub Date : 2022-07-27 Xianhu Sun, Dongxiang Wu, Lianfeng Zou, Stephen D. House, Xiaobo Chen, Meng Li, Dmitri N. Zakharov, Judith C. Yang, Guangwen Zhou
-
Dual action of ketamine confines addiction liability Nature (IF 69.504) Pub Date : 2022-07-27 Linda D. Simmler, Yue Li, Lotfi C. Hadjas, Agnès Hiver, Ruud van Zessen, Christian Lüscher
-
Dairying, diseases and the evolution of lactase persistence in Europe Nature (IF 69.504) Pub Date : 2022-07-27 Richard P. Evershed, George Davey Smith, Mélanie Roffet-Salque, Adrian Timpson, Yoan Diekmann, Matthew S. Lyon, Lucy J. E. Cramp, Emmanuelle Casanova, Jessica Smyth, Helen L. Whelton, Julie Dunne, Veronika Brychova, Lucija Šoberl, Pascale Gerbault, Rosalind E. Gillis, Volker Heyd, Emily Johnson, Iain Kendall, Katie Manning, Arkadiusz Marciniak, Alan K. Outram, Jean-Denis Vigne, Stephen Shennan, Andrew