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Resistance to Striga parasitism through reduction of strigolactone exudation Cell (IF 45.5) Pub Date : 2025-02-12 Jiayang Shi, Cuo Mei, Fengyong Ge, Qingliang Hu, Xinwei Ban, Ran Xia, Peiyong Xin, Shujing Cheng, Gaohua Zhang, Jiawei Nie, Shiqi Zhang, Xiaowei Ma, Yi Wang, Jinfang Chu, Yuhang Chen, Bing Wang, Weihua Wu, Jiayang Li, Qi Xie, Feifei Yu
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ArfGAP2 promotes STING proton channel activity, cytokine transit, and autoinflammation Cell (IF 45.5) Pub Date : 2025-02-12 Subhajit Poddar, Samuel D. Chauvin, Christopher H. Archer, Wei Qian, Jean A. Castillo-Badillo, Xin Yin, W. Miguel Disbennett, Cathrine A. Miner, Joe A. Holley, Teresa V. Naismith, W. Alexander Stinson, Xiaochao Wei, Yue Ning, Jiayuan Fu, Trini A. Ochoa, Nehalee Surve, Shivam A. Zaver, Kimberly A. Wodzanowski, Katherine R. Balka, Rajan Venkatraman, Jonathan J. Miner
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Transylvanian diaries reveal centuries-old climate extremes Nature (IF 50.5) Pub Date : 2025-02-12
Droughts, extreme heat and destructive flooding plagued the region in the sixteenth century, historical documents show.
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Dozens of new obesity drugs are coming: these are the ones to watch Nature (IF 50.5) Pub Date : 2025-02-12
Next-generation obesity drugs will work differently from Ozempic and Wegovy — aiming to deliver greater weight loss with fewer side effects.
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Why is mathematics education failing some of the world’s most talented children? Nature (IF 50.5) Pub Date : 2025-02-12
A study shines a light on the remarkable arithmetic skills that young people acquire outside formal schooling. Education must evolve to enable them to fulfil their potential.
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Author Correction: High fatigue resistance in a titanium alloy via near-void-free 3D printing Nature (IF 50.5) Pub Date : 2025-02-11 Zhan Qu, Zhenjun Zhang, Rui Liu, Ling Xu, Yining Zhang, Xiaotao Li, Zhenkai Zhao, Qiqiang Duan, Shaogang Wang, Shujun Li, Yingjie Ma, Xiaohong Shao, Rui Yang, Jürgen Eckert, Robert O. Ritchie, Zhefeng Zhang
Correction to: Nature https://doi.org/10.1038/s41586-024-07048-1 Published online 28 February 2024
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‘Aqua tweezers’ manipulate particles with water waves Nature (IF 50.5) Pub Date : 2025-02-11
Researchers create precise 3D patterns with water.
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Scientists fight Norway’s language law, warning of talent exodus Nature (IF 50.5) Pub Date : 2025-02-11
Mandatory language courses for foreign researchers could harm Norway’s ability to attract the best talent, Nobel laureate says, as rule prompts legal challenge.
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Daily briefing: ‘Devastating’ cuts to NIH grants blocked by legal challenge Nature (IF 50.5) Pub Date : 2025-02-11
Earth’s inner core is changing shape. Plus, a judge has blocked ‘devastating’ cuts to NIH grants in the United States.
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Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy Cell Stem Cell (IF 19.8) Pub Date : 2025-02-11 Tianping Peng, Xiujian Ma, Wei Hua, Changwen Wang, Youjun Chu, Meng Sun, Valentina Fermi, Stefan Hamelmann, Katharina Lindner, Chunxuan Shao, Julia Zaman, Weili Tian, Yue Zhuo, Yassin Harim, Nadja Stöffler, Linda Hammann, Qungen Xiao, Xiaoliang Jin, Rolf Warta, Catharina Lotsch, Ying Mao
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Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2 Cell (IF 45.5) Pub Date : 2025-02-11 Serena Lucotti, Yusuke Ogitani, Candia M. Kenific, Jacob Geri, Young Hun Kim, Jinghua Gu, Uthra Balaji, Linda Bojmar, Lee Shaashua, Yi Song, Michele Cioffi, Pernille Lauritzen, Oveen M. Joseph, Tetsuhiko Asao, Paul M. Grandgenett, Michael A. Hollingsworth, Christopher Peralta, Alexandra E. Pagano, Henrik Molina, Harry B. Lengel, David Lyden
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Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice Cell (IF 45.5) Pub Date : 2025-02-11 Nan Wang, Shasha Zhang, Peter Langfelder, Lalini Ramanathan, Fuying Gao, Mary Plascencia, Raymond Vaca, Xiaofeng Gu, Linna Deng, Leonardo E. Dionisio, Ha Vu, Emily Maciejewski, Jason Ernst, Brinda C. Prasad, Thomas F. Vogt, Steve Horvath, Jeffrey S. Aaronson, Jim Rosinski, X. William Yang
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Neutrophil-derived vesicles control complement activation to facilitate inflammation resolution Cell (IF 45.5) Pub Date : 2025-02-11 Alan Y. Hsu, Qingxiang Huang, Xiong Pi, Jianing Fu, Krishnan Raghunathan, Laxman Ghimire, Arumugam Balasubramanian, Xuemei Xie, Hongbo Yu, Fabien Loison, Viraga Haridas, Jiali Zha, Fei Liu, Shin-young Park, Kamal Bagale, Qian Ren, Yuping Fan, Yi Zheng, Jose A. Cancelas, Li Chai, Hongbo R. Luo
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Ribophagy relies on Rpl12 Nat. Cell Biol. (IF 17.3) Pub Date : 2025-02-11 Katarzyna Tutak, Katrin Karbstein
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Rpl12 is a conserved ribophagy receptor Nat. Cell Biol. (IF 17.3) Pub Date : 2025-02-11 Yuting Chen, Jiaxin Hu, Pengwei Zhao, Jie Fang, Yingqi Kuang, Zhaojie Liu, Shuling Dong, Weijing Yao, Yuanyuan Ding, Xinhui Wang, Yibin Pan, Jianbin Wu, Jingwei Zhao, Jing Yang, Zhenzhong Xu, Xiaodi Liu, Yi Zhang, Choufei Wu, Liqin Zhang, Mingzhu Fan, Shan Feng, Zhi Hong, Zhangming Yan, Hongguang Xia, Kaiyue Tang, Bing Yang, Wei Liu, Qiming Sun, Kunrong Mei, Wei Zou, Yunpeng Huang, Du Feng, Cong Yi
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Gains in early-onset dementia with progranulin open new paths for drug discovery Nat. Biotechnol. (IF 33.1) Pub Date : 2025-02-11
The first clinical results in patients with a genetic form of frontotemporal dementia (FTD) show that enhancing progranulin in the brain may halt disease progression. If successful, this potentially disease-modifying approach may uncover new avenues for treating other neurodegenerative diseases.
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Precise RNA targeting with CRISPR–Cas13d Nat. Biotechnol. (IF 33.1) Pub Date : 2025-02-11 Sydney K. Hart, Simon Müller, Hans-Hermann Wessels, Alejandro Méndez-Mancilla, Gediminas Drabavicius, Olivia Choi, Neville E. Sanjana
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Outdated rules on expenses prevent academics from travelling more sustainably Nature (IF 50.5) Pub Date : 2025-02-11
Letter to the Editor
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Amazing Australopithecus — excitement from 1925 about a ‘man ape’ fossil find Nature (IF 50.5) Pub Date : 2025-02-11
Snippets from Nature’s past.
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Close the biodiversity funding gap by teaching conservation to financial professionals Nature (IF 50.5) Pub Date : 2025-02-11
Letter to the Editor
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Nature markets are nothing new — they are widespread, regulated and instructive Nature (IF 50.5) Pub Date : 2025-02-11
Letter to the Editor
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Federico Mayor Zaragoza obituary: former UNESCO chief who championed neonatal screening Nature (IF 50.5) Pub Date : 2025-02-11
The biochemist introduced the first heel-prick tests for newborn babies in Spain, protecting infants from life-changing metabolic conditions.
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Your brain is full of microplastics: are they harming you? Nature (IF 50.5) Pub Date : 2025-02-11
Plastics have infiltrated every recess of the planet, including your lungs, kidneys and other sensitive organs. Scientists are scrambling to understand their effects on health.
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‘Male-dominated campuses belong to the past’: the University of Tokyo tackles the gender gap Nature (IF 50.5) Pub Date : 2025-02-11
A range of initiatives, from financial-support schemes to awareness campaigns, is already changing the university’s environment.
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Japan can be a science heavyweight once more — if it rethinks funding Nature (IF 50.5) Pub Date : 2025-02-11 Keisuke Goda, Tatsushi Igaki, Bernd Kuhn, Noboru Mizushima, Takeharu Nagai, Atsuhiro Nakagawa, Noriko Osumi, Amy Q. Shen, Masahiro Sonoshita, Masashi Yanagisawa
The nation must lose its tight focus on individual disciplines if it is to keep pace with the evolving requirements of scientific enquiry.
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Earth’s mysterious inner core really is changing shape Nature (IF 50.5) Pub Date : 2025-02-10
Earthquakes ringing through the planet illuminate how its heart is transforming.
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The Greenland Ice Sheet is fracturing faster than expected Nature (IF 50.5) Pub Date : 2025-02-10 Holly Smith
Cracks in Greenland's glaciers deepened by climate change.
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A man was destined for early Alzheimer’s — these genes might explain his escape Nature (IF 50.5) Pub Date : 2025-02-10
Scientists identify nine genetic variants that could have helped a man to avoid dementia for at least two decades longer than expected.
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Daily briefing: How did childhood evolve? Nature (IF 50.5) Pub Date : 2025-02-10
An AI system is crushing it at the International Mathematical Olympiad. Plus, what an iconic fossil teaches us about the evolution of childhood.
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‘Devastating’ cuts to NIH grants by Trump’s team put on hold by US judge Nature (IF 50.5) Pub Date : 2025-02-10
The ruling temporarily halts a policy slashing research overhead costs in 22 states, which filed a lawsuit against the biomedical agency.
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Author Correction: A map of the rubisco biochemical landscape Nature (IF 50.5) Pub Date : 2025-02-10 Noam Prywes, Naiya R. Phillips, Luke M. Oltrogge, Sebastian Lindner, Leah J. Taylor-Kearney, Yi-Chin Candace Tsai, Benoit de Pins, Aidan E. Cowan, Hana A. Chang, Renée Z. Wang, Laina N. Hall, Daniel Bellieny-Rabelo, Hunter M. Nisonoff, Rachel F. Weissman, Avi I. Flamholz, David Ding, Abhishek Y. Bhatt, Oliver Mueller-Cajar, Patrick M. Shih, Ron Milo, David F. Savage
Correction to: Nature https://doi.org/10.1038/s41586-024-08455-0 Published online 22 January 2025
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Substrate and climate determine terrestrial litter decomposition Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Qiuxia Wu, Xiangyin Ni, Xinyao Sun, Zihao Chen, Songbai Hong, Björn Berg, Mianhai Zheng, Ji Chen, Jingjing Zhu, Ling Ai, Yichen Zhang, Fuzhong Wu
Litter decomposition is a fundamental biogeochemical process for carbon flux and nutrient cycling in terrestrial ecosystems, yet the global variation in decomposition rates and their covariations with climate and substrate are not fully understood. Here, we synthesized a global dataset of 6,733 independent observations across six continents to illustrate the climatic and substrate controls over litter
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Adapting C 4 photosynthesis to atmospheric change and increasing productivity by elevating Rubisco content in sorghum and sugarcane Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Coralie E. Salesse-Smith, Noga Adar, Baskaran Kannan, Thaibinhduong Nguyen, Wei Wei, Ming Guo, Zhengxiang Ge, Fredy Altpeter, Tom E. Clemente, Stephen P. Long
Meta-analyses and theory show that with rising atmospheric [CO 2 ], Rubisco has become the greatest limitation to light-saturated leaf CO 2 assimilation rates ( A sat ) in C 4 crops. So would transgenically increasing Rubisco increase A sat and result in increased productivity in the field? Here, we successfully overexpressed the Rubisco small subunit ( RbcS ) with Rubisco accumulation factor 1 ( Raf1
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Computational and in vitro evaluation of probiotic treatments for nasal Staphylococcus aureus decolonization Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Burcu Tepekule, Weronika Barcik, Willy I. Staiger, Judith Bergadà-Pijuan, Thomas Scheier, Laura Brülisauer, Alex R. Hall, Huldrych F. Günthard, Markus Hilty, Roger D. Kouyos, Silvio D. Brugger
Despite the rising challenge of antibiotic resistance, current approaches to eradicate nasal pathobionts Staphylococcus aureus and Streptococcus pneumoniae rely on antibacterials. An alternative is the artificial inoculation of commensal bacteria, i.e., probiotic treatment, supported by the increasing evidence for commensal-mediated inhibition of pathogens. To systematically investigate the potential
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A deep learning–enabled smart garment for accurate and versatile monitoring of sleep conditions in daily life Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Chenyu Tang, Wentian Yi, Muzi Xu, Yuxuan Jin, Zibo Zhang, Xuhang Chen, Caizhi Liao, Mengtian Kang, Shuo Gao, Peter Smielewski, Luigi G. Occhipinti
In wearable smart systems, continuous monitoring and accurate classification of different sleep-related conditions are critical for enhancing sleep quality and preventing sleep-related chronic conditions. However, the requirements for device–skin coupling quality in electrophysiological sleep monitoring systems hinder the comfort and reliability of night wearing. Here, we report a washable, skin-compatible
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Allosteric genetically encoded biosensor for spatiotemporal monitoring of endogenous RNA dynamics in living cells Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Deyu Yuan, Huan He, William Song, Duhan Ma, Mingfeng Xie, Yuchun Wang, Jinliang Wei, Qianyu He, Yongli Bao, Yongyun Zhao
Functions of RNAs are associated with their abundance and unique subcellular localizations. RNA imaging methods for spatiotemporal monitoring of RNA dynamics would facilitate the discovery of unknown functions of RNA, yet improving RNA imaging is challenging because of limitations in methods for directly monitoring native RNA, especially the dynamics of RNA transport and concentration fluctuation.
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Bacterial polysaccharide lyase family 33: Specificity from an evolutionarily conserved binding tunnel Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Mélanie Loiodice, Elodie Drula, Zak McIver, Svetlana Antonyuk, Arnaud Baslé, Marcelo Lima, Edwin A. Yates, Dominic P. Byrne, Jamie Coughlan, Andrew Leech, Shahram Mesdaghi, Daniel J. Rigden, Sophie Drouillard, William Helbert, Bernard Henrissat, Nicolas Terrapon, Gareth S. A. Wright, Marie Couturier, Alan Cartmell
Acidic glycans are essential for the biology of multicellular eukaryotes. To utilize them, microbial life including symbionts and pathogens has evolved polysaccharide lyases (PL) that cleave their 1,4 glycosidic linkages via a β-elimination mechanism. PL family 33 (PL33) enzymes have the unusual ability to target a diverse range of glycosaminoglycans (GAGs), as well as the bacterial polymer, gellan
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Geometric modeling of knitted fabrics Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Lauren Niu, Geneviève Dion, Randall D. Kamien
Knitting can turn a one-dimensional yarn into a highly ramified three-dimensional structure. As a method of additive manufacturing, it holds promise for a class of lightweight, ultrastrong materials. Here, we present a purely geometric model to predict the three-dimensional self-folding of knitted fabrics made only of the two traditional stitches, knit and purl.
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Flake production: A universal by-product of primate stone percussion Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Tomos Proffitt, Paula de Sousa Medeiros, Waldney Pereira Martins, Lydia. V. Luncz
The evolution of stone tool technology marks a significant milestone in hominin development, enabling early humans to manipulate their environments. The oldest known evidence, dating to 3.3 Ma, indicates a combination of percussive and flake production activities. Studying the archaeological signature of percussive stone tool use in living primate provides a potential analog to the origin of stone
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Scavenger endothelial cells alleviate tissue damage by engulfing toxic molecules derived from hemolysis Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-11 Yimei Dai, Yunyun Jiang, Canran Cao, Yongtai Xu, Siting Lai, Wenchao Zhu, Meng Gao, Feifei Li, Sicong He, Jin Xu
Hemolysis induces tissue damage by releasing cellular contents into the plasma. It is widely accepted that hemolysis-derived toxic molecules are cleared by macrophages or metabolized in hepatocytes. In zebrafish, we found that scavenger endothelial cells (SECs), a specialized endothelium with remarkable endocytosis capability, engulf both macromolecular hemoglobin (Hb) and small molecular unconjugated
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The African Animal Breeding Network as a pathway towards genetic improvement of livestock Nat. Genet. (IF 31.7) Pub Date : 2025-02-10 Appolinaire Djikeng, Victor E. Olori, Isidore Houaga, Samuel E. Aggrey, Okeyo Mwai, Eveline M. Ibeagha-Awemu, Raphael Mrode, Mizeck G. G. Chagunda, Christian K. Tiambo, Romdhane Rekaya, Oyenkanmi Nash, Zabron Nziku, Oluyinka Opoola, Mapholi Ntanganedzeni, Chinyere Ekine-Dzivenu, Alexander Kahi, Tobias Okeno, John M. Hickey, Negussie Enyew, Edward J. O. Rege
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Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer Nat. Genet. (IF 31.7) Pub Date : 2025-02-10 Slim Mzoughi, Megan Schwarz, Xuedi Wang, Deniz Demircioglu, Gulay Ulukaya, Kevin Mohammed, Habiba Zorgati, Denis Torre, Lewis E. Tomalin, Federico Di Tullio, Carlos Company, Yuliia Dramaretska, Marc Leushacke, Bruno Giotti, Tamsin RM Lannagan, Daniel Lozano-Ojalvo, Panagiotis Karras, Peter B. Vermeulen, Dan Hasson, Robert Sebra, Alexander M. Tsankov, Owen J. Sansom, Jean-Christophe Marine, Nick Barker
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Prioritizing effector genes at trait-associated loci using multimodal evidence Nat. Genet. (IF 31.7) Pub Date : 2025-02-10 Marijn Schipper, Christiaan A. de Leeuw, Bernardo A. P. C. Maciel, Douglas P. Wightman, Nikki Hubers, Dorret I. Boomsma, Michael C. O’Donovan, Danielle Posthuma
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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups Nat. Genet. (IF 31.7) Pub Date : 2025-02-10 Thomas J. Hoffmann, Rebecca E. Graff, Ravi K. Madduri, Alex A. Rodriguez, Clinton L. Cario, Karen Feng, Yu Jiang, Anqi Wang, Robert J. Klein, Brandon L. Pierce, Scott Eggener, Lin Tong, William Blot, Jirong Long, Louisa B. Goss, Burcu F. Darst, Timothy Rebbeck, Joseph Lachance, Caroline Andrews, Akindele O. Adebiyi, Ben Adusei, Oseremen I. Aisuodionoe-Shadrach, Pedro W. Fernandez, Mohamed Jalloh, Rohini
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I grow medicinal mushrooms in my renewable-energy laboratory Nature (IF 50.5) Pub Date : 2025-02-10
When Ho Thi Thanh Van isn’t creating materials for fuel cells, she is cultivating traditional medicines.
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Breaking language barriers: ‘Not being fluent in English is often viewed as being an inferior scientist’ Nature (IF 50.5) Pub Date : 2025-02-10
Biologist Tatsuya Amano works to make science a fairer place for non-fluent speakers.
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How to end outrage and detoxify politics: share stories, not statistics Nature (IF 50.5) Pub Date : 2025-02-10
A book on human morality claims that although liberals and conservatives prioritize different victims, mutual understanding is still possible.
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How and why my company pivoted from energy to agritechnology Nature (IF 50.5) Pub Date : 2025-02-10
Lambda Agri chief executive Monica Saavedra describes funding strategies and the circumstances leading to the company changing strategic direction.
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Daily briefing: People in dense crowds move in swirls Nature (IF 50.5) Pub Date : 2025-02-07
People begin to move in vortices in densely packed crowds. Plus, the scientists who kept research alive in Gaza during the Israel–Hamas conflict.
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Daily briefing: How mantis shrimps survive landing the world’s fastest punch Nature (IF 50.5) Pub Date : 2025-02-07
What’s behind the mantis shrimp’s powerful punch? Plus, six ways to cultivate allyship for a diverse, equitable and inclusive academia.
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Decoding resistance in the age of T6SS warfare. Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Nicholas J Shikuma
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Photostationary state assumption seriously underestimates NOx emissions near large point sources at 10 to 60 m pixel resolution. Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Lang Chen,Zhe Song,Ningning Yao,Huan Xi,Jian Li,Peng Gao,Yulei Chen,Haoyuan Su,Yuhai Sun,Boqiong Jiang,Jianmin Chen,Yuanhang Zhang,Tong Zhu,Pengfei Li,Xiaobing Pang,Shaocai Yu
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Interrogating nucleotide sequences with AI to understand codon usage patterns. Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Assaf Elazar,Steve Mathew D A,M Madan Babu
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Reply to Chen et al.: Coarse simulations overestimate the distance to recover NO-NO2-O3 photochemical steady state in fresh NOx plumes. Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Daniel J Varon,Dylan Jervis,Sudhanshu Pandey,Sebastian L Gallardo,Nicholas Balasus,Laura Hyesung Yang,Daniel J Jacob
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Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Benjamin W. Neuman, Alexandria Smart, Orian Gilmer, Redmond P. Smyth, Josef Vaas, Nicolai Böker, Dmitry V. Samborskiy, Ralf Bartenschlager, Stefan Seitz, Alexander E. Gorbalenya, Neva Caliskan, Chris Lauber
Positive-strand RNA viruses of the order Nidovirales have the largest known RNA genomes of vertebrate and invertebrate viruses with 36.7 and 41.1 kb, respectively. The acquisition of a proofreading exoribonuclease (ExoN) by an ancestral nidovirus enabled crossing of the 20 kb barrier. Other factors constraining genome size variations in nidoviruses remain poorly defined. We assemble 76 genome sequences
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Ancient origin and high diversity of zymocin-like killer toxins in the budding yeast subphylum Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Padraic G. Heneghan, Letal I. Salzberg, Eoin Ó Cinnéide, Jan A. Dewald, Christina E. Weinberg, Kenneth H. Wolfe
Zymocin is a well-characterized killer toxin secreted by some strains of the yeast Kluyveromyces lactis . It acts by cleaving a specific tRNA in sensitive recipient cells. Zymocin is encoded by a killer plasmid or virus-like element (VLE), which is a linear DNA molecule located in the cytosol. We hypothesized that a tRNA-cleaving toxin similar to zymocin may have caused the three parallel changes to
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Clinical evaluation of patterned dried plasma spot cards to support quantification of HIV viral load and reflexive genotyping Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Giorgio Gianini Morbioli, Keith R. Baillargeon, Monalisa N. Kalimashe, Vibha Kana, Hloniphile Zwane, Cheri van der Walt, Allison J. Tierney, Andrea C. Mora, Mark Goosen, Rivashni Jagaroo, Jessica C. Brooks, Ewaldé Cutler, Gillian Hunt, Michael R. Jordan, Alice Tang, Charles R. Mace
Quantifying viral load, a key indicator required to achieve control and elimination of the HIV epidemic, requires cell-free plasma or serum to ensure measurements are not biased by proviral DNA contained in infected CD4 T lymphocytes. Plasma separation cards (PSC) collect and preserve a dried specimen, which makes them practical solutions for decentralized sample collection and transport in limited-resource
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Reenacting a mouse genetic evolutionary arms race in yeast reveals that SLXL1/SLX compete with SLY1/2 for binding to Spindlins Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2025-02-10 Martin F. Arlt, Alyssa N. Kruger, Callie M. Swanepoel, Jacob L. Mueller
The house mouse X and Y chromosomes have recently acquired multicopy, rapidly evolving gene families representing an evolutionary arms race. This arms race between proteins encoded by X-linked Slxl1 / Slx and Y-linked Sly gene families can distort offspring sex ratio, but how these proteins compete remains unknown. Here, we report how Slxl1 / Slx and Sly encoded proteins compete in a protein family–specific