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Why you should love wasps, and what is emotion? Books in brief Nature (IF 49.962) Pub Date : 2022-06-24
Andrew Robinson reviews five of the week’s best science picks.
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Into high gear: material made of cogs stiffens or flexes on command Nature (IF 49.962) Pub Date : 2022-06-24
A strong material becomes more rigid or more relaxed when its constituent gears are spun.
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Daily briefing: Rare ‘triple-dip’ La Niña climate event looks likely Nature (IF 49.962) Pub Date : 2022-06-23
A long-running La Niña climate event could persist into 2023. Plus, breast cancer cells are more likely to go rogue at night, and research to quantify and reduce inequality.
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What Omicron’s BA.4 and BA.5 variants mean for the pandemic Nature (IF 49.962) Pub Date : 2022-06-23
The lineages’ rise seems to stem from their ability to infect people who were immune to earlier forms of Omicron and other variants.
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Largest bacterium ever found is surprisingly complex Nature (IF 49.962) Pub Date : 2022-06-23
‘Microorganism’ is a misnomer when it comes to centimetre-long Thiomargarita magnifica.
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Separating molecules by their shapes can purify natural gas Nature (IF 49.962) Pub Date : 2022-06-22
Membranes with methane-excluding pores can remove nitrogen and carbon dioxide from natural gas in an energy-efficient and cost-effective way.
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Hijacked-journal tracker helps researchers to spot scam websites Nature (IF 49.962) Pub Date : 2022-06-22
Scientists can now check whether a journal website has been cloned before submitting their manuscript.
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APOE told me put my fat in the bag and nobody gets hurt Cell (IF 41.582) Pub Date : 2022-06-23 Garam Kim, Aaron D. Gitler
The ε4 variant in the APOE gene is the strongest genetic risk factor for Alzheimer’s disease. How does this gene impact different cell types in the brain to increase disease risk? In this issue of Cell, TCW and colleagues report APOE-driven cell-type-specific changes that may contribute to Alzheimer’s disease risk.
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BacPROTACs to basics: Targeted protein degradation in bacteria Cell (IF 41.582) Pub Date : 2022-06-23 George M. Burslem
Targeted protein degradation has emerged as a powerful tool for therapeutic development and biological exploration. In this issue of Cell, Morreale et al. report the development of the BacPROTAC technology to enable targeted protein degradation in Gram-positive bacteria and mycobacteria via reprogramming of Clp proteases.
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Shigella “Osp”pression of innate immunity Cell (IF 41.582) Pub Date : 2022-06-23 Skylar S. Wright, Sivapriya Kailasan Vanaja
Interferons are potent antimicrobial effectors and thus an attractive target for pathogen interference. In this issue of Cell, Alphonse et al. reveal that the Shigella effectors OspC1 and OspC3 employ a surprising mechanism to block interferon signaling and attenuate antibacterial responses, thus securing their replicative niche.
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TIR domains as two-tiered enzymes to activate plant immunity Cell (IF 41.582) Pub Date : 2022-06-23 Lei Tian, Xin Li
Plant immune receptors often contain TIR domains, which can oligomerize to form active enzyme complexes in response to pathogen infections. In this issue of Cell, Yu and colleagues discover that some plant TIR domains possess a novel 2′,3′-cAMP/cGMP synthetase activity that cleaves double-stranded RNA/DNA, triggering cell death during plant immune responses.
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New antivirals exploit viral feedback tricks for a cure without resistance Cell (IF 41.582) Pub Date : 2022-06-23 Gábor Balázsi
Many approved drugs, including antivirals, are small-molecule inhibitors of disease-causing proteins. Such inhibitors often elicit resistance during treatment. Chaturvedi et al. propose new, feedback-disruptor (FD) antivirals that efficiently cure infected cells from viruses and minimize the chance of resistance, providing a new paradigm to treat viral infections and possibly other diseases.
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Cholesterol and matrisome pathways dysregulated in astrocytes and microglia Cell (IF 41.582) Pub Date : 2022-06-23 Julia TCW, Lu Qian, Nina H. Pipalia, Michael J. Chao, Shuang A. Liang, Yang Shi, Bharat R. Jain, Sarah E. Bertelsen, Manav Kapoor, Edoardo Marcora, Elizabeth Sikora, Elizabeth J. Andrews, Alessandra C. Martini, Celeste M. Karch, Elizabeth Head, David M. Holtzman, Bin Zhang, Minghui Wang, Alison M. Goate
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Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes Cell (IF 41.582) Pub Date : 2022-06-23 Meiqin Hu, Ping Li, Ce Wang, Xinghua Feng, Qi Geng, Wei Chen, Matangi Marthi, Wenlong Zhang, Chenlang Gao, Whitney Reid, Joel Swanson, Wanlu Du, Richard I. Hume, Haoxing Xu
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Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation Cell (IF 41.582) Pub Date : 2022-06-23 Tzu-Tang Wei, Mark Chandy, Masataka Nishiga, Angela Zhang, Kaavya Krishna Kumar, Dilip Thomas, Amit Manhas, Siyeon Rhee, Johanne Marie Justesen, Ian Y. Chen, Hung-Ta Wo, Saereh Khanamiri, Johnson Y. Yang, Frederick J. Seidl, Noah Z. Burns, Chun Liu, Nazish Sayed, Jiun-Jie Shie, Joseph C. Wu
Abstract not available
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Circular RNAs: Characterization, cellular roles, and applications Cell (IF 41.582) Pub Date : 2022-06-23 Chu-Xiao Liu, Ling-Ling Chen
Abstract not available
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Linking genetic variants to kidney disease via the epigenome Nat. Genet. (IF 38.33) Pub Date : 2022-06-23
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Graph pangenomes find missing heritability Nat. Genet. (IF 38.33) Pub Date : 2022-06-23 David Edwards, Jacqueline Batley
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Reply to Zhen and Yu: Cognitive control as questionable proxy for deliberation in honest behaviors Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-21 Gabriele BellucciChongxiang WangLiyang SaiFrank KruegeraDepartment of Computational Neuroscience, Max Planck Institute for Biological Cybernetics, Tubingen 72076, GermanybDepartment of Psychology, Hangzhou Normal University, Hangzhou 311121, ChinacSchool of Systems Biology, George Mason University, Fairfax, VA 22032
Proceedings of the National Academy of Sciences, Volume 119, Issue 27, July 2022.
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Reply to Roy and Pucadyil: A gain of function by a GTPase-impaired Drp1 Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-21 Isabel Pérez-JoverPooja Madan MohanRajesh RamachandranAnna V. ShnyrovaaInstituto Biofisika, University of the Basque Country, 48940 Leioa, SpainbDepartment of Biochemistry and Molecular Biology, University of the Basque Country, 48940 Leioa, SpaincDepartment of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106dCleveland Center for Membrane and Structural Biology, Case
Proceedings of the National Academy of Sciences, Volume 119, Issue 27, July 2022.
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Spontaneous dishonesty does not specifically engage the perigenual anterior cingulate cortex Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-21 Shanshan ZhenRongjun YuaDepartment of Management, Hong Kong Baptist University, Hong Kong, 999077, China
Proceedings of the National Academy of Sciences, Volume 119, Issue 27, July 2022.
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Is Drp1 sufficient to catalyze membrane fission? Proc. Natl. Acad. Sci. U.S.A. (IF 11.205) Pub Date : 2022-06-21 Krishnendu RoyThomas J. PucadyilaDepartment of Biology, Indian Institute of Science Education and Research, Maharashtra, 411008 India
Proceedings of the National Academy of Sciences, Volume 119, Issue 27, July 2022.
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Actin remodelling controls proteasome homeostasis upon stress Nat. Cell Biol. (IF 28.824) Pub Date : 2022-06-23 Thomas David Williams, Roberta Cacioppo, Alexander Agrotis, Ailsa Black, Houjiang Zhou, Adrien Rousseau
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The conserved helicase ZNFX-1 memorializes silenced RNAs in perinuclear condensates Nat. Cell Biol. (IF 28.824) Pub Date : 2022-06-23 John Paul Tsu Ouyang, Wenyan Lucy Zhang, Geraldine Seydoux
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Ceramide-rich microdomains facilitate nuclear envelope budding for non-conventional exosome formation Nat. Cell Biol. (IF 28.824) Pub Date : 2022-06-23 Subhash B. Arya, Song Chen, Fatima Jordan-Javed, Carole A. Parent
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David A. Evans (1941–2022) Nature (IF 49.962) Pub Date : 2022-06-23
Chemist who developed ways to synthesize and depict bioactive products.
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Monkeypox in Africa: the science the world ignored Nature (IF 49.962) Pub Date : 2022-06-23
African researchers have been warning about monkeypox outbreaks for years. As vaccines are deployed globally, they worry they will be left behind.
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Rare ‘triple’ La Niña climate event looks likely — what does the future hold? Nature (IF 49.962) Pub Date : 2022-06-23
Meteorologists are forecasting a third consecutive year of La Niña. Some researchers say similar conditions could become more common as the planet warms.
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Integrated multiomic characterization of congenital heart disease Nature (IF 49.962) Pub Date : 2022-06-22 Matthew C. Hill, Zachary A. Kadow, Hali Long, Yuka Morikawa, Thomas J. Martin, Emma J. Birks, Kenneth S. Campbell, Jeanne Nerbonne, Kory Lavine, Lalita Wadhwa, Jun Wang, Diwakar Turaga, Iki Adachi, James F. Martin
The heart, the first organ to develop, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of CHD patients survive into adulthood but often suffer premature death from heart failure (HF) and non-cardiac causes 1. To gain insight into poorly understood disease progression, we performed single nuclear RNA sequencing (snRNA-seq)
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Women are Credited Less in Science than are Men Nature (IF 49.962) Pub Date : 2022-06-22 Matthew B. Ross, Britta M. Glennon, Raviv Murciano-Goroff, Enrico G. Berkes, Bruce A. Weinberg, Julia I. Lane
There is a well-documented gap in the observed number of scientific works produced by women and men in science, with clear consequences for the retention and promotion of women in science1. The gap might be a result of productivity differences2-5, or it might be due to women’s contributions not being acknowledged6,7. This paper finds that at least part of this gap is due to the latter: women in research
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Quantum microphone is a leap ahead of the competition Nature (IF 49.962) Pub Date : 2022-06-22
Low-powered technology based on entangled photons delivers clearer sound than a classical equivalent.
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How science can tackle inequality Nature (IF 49.962) Pub Date : 2022-06-22
Hear the biggest stories from the world of science | 22 June 2022
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The pandemic's unequal toll Nature (IF 49.962) Pub Date : 2022-06-22
COVID has exposed stark inequality - we walk through the latest data
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What did megalodon the mega-toothed shark eat? Anything it wanted Nature (IF 49.962) Pub Date : 2022-06-22
These extinct uber-predators occupied an ecological niche that has no known equivalent in the modern ocean.
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Shark researcher attacks lack of diversity in marine science Nature (IF 49.962) Pub Date : 2022-06-22
Jasmin Graham has a passion for predators and promoting inclusive science.
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Landfalling hurricane track modes and decay Nature (IF 49.962) Pub Date : 2022-06-22 Kelvin T. F. Chan, Kailin Zhang, Yue Wu, Johnny C. L. Chan
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Reply to: Landfalling hurricane track modes and decay Nature (IF 49.962) Pub Date : 2022-06-22 Lin Li, Pinaki Chakraborty
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Engineering topological states in atom-based semiconductor quantum dots Nature (IF 49.962) Pub Date : 2022-06-22 M. Kiczynski, S. K. Gorman, H. Geng, M. B. Donnelly, Y. Chung, Y. He, J. G. Keizer, M. Y. Simmons
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Ablation of cDC2 development by triple mutations within the Zeb2 enhancer Nature (IF 49.962) Pub Date : 2022-06-22 Tian-Tian Liu, Sunkyung Kim, Pritesh Desai, Do-Hyun Kim, Xiao Huang, Stephen T. Ferris, Renee Wu, Feiya Ou, Takeshi Egawa, Steven J. Van Dyken, Michael S. Diamond, Peter F. Johnson, Masato Kubo, Theresa L. Murphy, Kenneth M. Murphy
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Two-dimensional materials prospects for non-volatile spintronic memories Nature (IF 49.962) Pub Date : 2022-06-22 Hyunsoo Yang, Sergio O. Valenzuela, Mairbek Chshiev, Sébastien Couet, Bernard Dieny, Bruno Dlubak, Albert Fert, Kevin Garello, Matthieu Jamet, Dae-Eun Jeong, Kangho Lee, Taeyoung Lee, Marie-Blandine Martin, Gouri Sankar Kar, Pierre Sénéor, Hyeon-Jin Shin, Stephan Roche
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Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy Nature (IF 49.962) Pub Date : 2022-06-22 Mark Chaffin, Irinna Papangeli, Bridget Simonson, Amer-Denis Akkad, Matthew C. Hill, Alessandro Arduini, Stephen J. Fleming, Michelle Melanson, Sikander Hayat, Maria Kost-Alimova, Ondine Atwa, Jiangchuan Ye, Kenneth C. Bedi, Matthias Nahrendorf, Virendar K. Kaushik, Christian M. Stegmann, Kenneth B. Margulies, Nathan R. Tucker, Patrick T. Ellinor
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Biosynthetic potential of the global ocean microbiome Nature (IF 49.962) Pub Date : 2022-06-22 Lucas Paoli, Hans-Joachim Ruscheweyh, Clarissa C. Forneris, Florian Hubrich, Satria Kautsar, Agneya Bhushan, Alessandro Lotti, Quentin Clayssen, Guillem Salazar, Alessio Milanese, Charlotte I. Carlström, Chrysa Papadopoulou, Daniel Gehrig, Mikhail Karasikov, Harun Mustafa, Martin Larralde, Laura M. Carroll, Pablo Sánchez, Ahmed A. Zayed, Dylan R. Cronin, Silvia G. Acinas, Peer Bork, Chris Bowler, Tom
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Asymmetric pore windows in MOF membranes for natural gas valorization Nature (IF 49.962) Pub Date : 2022-06-22 Sheng Zhou, Osama Shekhah, Adrian Ramírez, Pengbo Lyu, Edy Abou-Hamad, Jiangtao Jia, Jiantang Li, Prashant M. Bhatt, Zhiyuan Huang, Hao Jiang, Tian Jin, Guillaume Maurin, Jorge Gascon, Mohamed Eddaoudi
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Life rather than climate influences diversity at scales greater than 40 million years Nature (IF 49.962) Pub Date : 2022-06-22 Andrej Spiridonov, Shaun Lovejoy
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Observation of a correlated free four-neutron system Nature (IF 49.962) Pub Date : 2022-06-22 M. Duer, T. Aumann, R. Gernhäuser, V. Panin, S. Paschalis, D. M. Rossi, N. L. Achouri, D. Ahn, H. Baba, C. A. Bertulani, M. Böhmer, K. Boretzky, C. Caesar, N. Chiga, A. Corsi, D. Cortina-Gil, C. A. Douma, F. Dufter, Z. Elekes, J. Feng, B. Fernández-Domínguez, U. Forsberg, N. Fukuda, I. Gasparic, Z. Ge, J. M. Gheller, J. Gibelin, A. Gillibert, K. I. Hahn, Z. Halász, M. N. Harakeh, A. Hirayama, M. Holl
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eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining Nature (IF 49.962) Pub Date : 2022-06-22 Christopher P. Lapointe, Rosslyn Grosely, Masaaki Sokabe, Carlos Alvarado, Jinfan Wang, Elizabeth Montabana, Nancy Villa, Byung-Sik Shin, Thomas E. Dever, Christopher S. Fraser, Israel S. Fernández, Joseph D. Puglisi
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cBAF complex components and MYC cooperate early in CD8+ T cell fate Nature (IF 49.962) Pub Date : 2022-06-22 Ao Guo, Hongling Huang, Zhexin Zhu, Mark J. Chen, Hao Shi, Sujing Yuan, Piyush Sharma, Jon P. Connelly, Swantje Liedmann, Yogesh Dhungana, Zhenrui Li, Dalia Haydar, Mao Yang, Helen Beere, Jason T. Yustein, Christopher DeRenzo, Shondra M. Pruett-Miller, Jeremy Chase Crawford, Giedre Krenciute, Charles W. M. Roberts, Hongbo Chi, Douglas R. Green
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PIEZO1 transduces mechanical itch in mice Nature (IF 49.962) Pub Date : 2022-06-22 Rose Z. Hill, Meaghan C. Loud, Adrienne E. Dubin, Brooke Peet, Ardem Patapoutian
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Organic bipolar transistors Nature (IF 49.962) Pub Date : 2022-06-22 Shu-Jen Wang, Michael Sawatzki, Ghader Darbandy, Felix Talnack, Jörn Vahland, Marc Malfois, Alexander Kloes, Stefan Mannsfeld, Hans Kleemann, Karl Leo
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The gut metabolite indole-3 propionate promotes nerve regeneration and repair Nature (IF 49.962) Pub Date : 2022-06-22 Elisabeth Serger, Lucia Luengo-Gutierrez, Jessica S. Chadwick, Guiping Kong, Luming Zhou, Greg Crawford, Matt C. Danzi, Antonis Myridakis, Alexander Brandis, Adesola Temitope Bello, Franziska Müller, Alexandros Sanchez-Vassopoulos, Francesco De Virgiliis, Phoebe Liddell, Marc Emmanuel Dumas, Jessica Strid, Sridhar Mani, Dylan Dodd, Simone Di Giovanni
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Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4 Nature (IF 49.962) Pub Date : 2022-06-22 Laura Campisi, Shahab Chizari, Jessica S. Y. Ho, Anastasia Gromova, Frederic Arnold, Lorena Mosca, Xueyan Mei, Yesai Fstkchyan, Denis Torre, Cindy Beharry, Marta Garcia-Forn, Miguel Jiménez-Alcázar, Vladislav A. Korobeynikov, Jack Prazich, Zahi A. Fayad, Marcus M. Seldin, Silvia De Rubeis, Craig L. Bennett, Lyle W. Ostrow, Christian Lunetta, Massimo Squatrito, Minji Byun, Neil A. Shneider, Ning Jiang
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De novo design of discrete, stable 310-helix peptide assemblies Nature (IF 49.962) Pub Date : 2022-06-22 Prasun Kumar, Neil G. Paterson, Jonathan Clayden, Derek N. Woolfson
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The metastatic spread of breast cancer accelerates during sleep Nature (IF 49.962) Pub Date : 2022-06-22 Zoi Diamantopoulou, Francesc Castro-Giner, Fabienne Dominique Schwab, Christiane Foerster, Massimo Saini, Selina Budinjas, Karin Strittmatter, Ilona Krol, Bettina Seifert, Viola Heinzelmann-Schwarz, Christian Kurzeder, Christoph Rochlitz, Marcus Vetter, Walter Paul Weber, Nicola Aceto
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Many-body theory of positron binding to polyatomic molecules Nature (IF 49.962) Pub Date : 2022-06-22 Jaroslav Hofierka, Brian Cunningham, Charlie M. Rawlins, Charles H. Patterson, Dermot G. Green
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Hadean isotopic fractionation of xenon retained in deep silicates Nature (IF 49.962) Pub Date : 2022-06-22 Igor Rzeplinski, Chrystèle Sanloup, Eric Gilabert, Denis Horlait
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Cryo-EM structure of a type IV secretion system Nature (IF 49.962) Pub Date : 2022-06-22 Kévin Macé, Abhinav K. Vadakkepat, Adam Redzej, Natalya Lukoyanova, Clasien Oomen, Nathalie Braun, Marta Ukleja, Fang Lu, Tiago R. D. Costa, Elena V. Orlova, David Baker, Qian Cong, Gabriel Waksman
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Tackling inequality takes social reform Nature (IF 49.962) Pub Date : 2022-06-22
In separate books, leading economists explore the wide-ranging changes needed to produce a more just society.
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Daily briefing: COVID czar Ashish Jha on the United States’ pandemic future Nature (IF 49.962) Pub Date : 2022-06-22
‘This is not an acceptable normal for the long run,’ says US COVID czar Ashish Jha. Plus, the biodiversity COP15 will move to Canada and a gentler sonar based on shrimp snaps.
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‘Ignored and not appreciated’: Women’s research contributions often go unrecognized Nature (IF 49.962) Pub Date : 2022-06-22
Data reveal that to earn credit on scientific articles, women need to work harder than men.
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A postdoc’s guide to choosing the right lab Nature (IF 49.962) Pub Date : 2022-06-22
Allison McClure describes how she secured her first postdoctoral position and shares her thoughts on how laboratories can attract candidates.