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Amyloplast sedimentation repolarizes LAZYs to achieve gravity sensing in plants Cell (IF 64.5) Pub Date : 2023-09-22 Jiayue Chen, Renbo Yu, Na Li, Zhaoguo Deng, Xinxin Zhang, Yaran Zhao, Chengfu Qu, Yanfang Yuan, Zhexian Pan, Yangyang Zhou, Kunlun Li, Jiajun Wang, Zhiren Chen, Xiaoyi Wang, Xiaolian Wang, Shu-Nan He, Juan Dong, Xing Wang Deng, Haodong Chen
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SARS-CoV-2 variants evolve convergent strategies to remodel the host response Cell (IF 64.5) Pub Date : 2023-09-21 Mehdi Bouhaddou, Ann-Kathrin Reuschl, Benjamin J. Polacco, Lucy G. Thorne, Manisha R. Ummadi, Chengjin Ye, Romel Rosales, Adrian Pelin, Jyoti Batra, Gwendolyn M. Jang, Jiewei Xu, Jack M. Moen, Alicia L. Richards, Yuan Zhou, Bhavya Harjai, Erica Stevenson, Ajda Rojc, Roberta Ragazzini, Matthew V.X. Whelan, Wilhelm Furnon, Nevan J. Krogan
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Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-21 Miguel Bernabé-Rubio, Shahnawaz Ali, Priyanka G. Bhosale, Georgina Goss, Seyedeh Atefeh Mobasseri, Rafael Tapia-Rojo, Tong Zhu, Toru Hiratsuka, Matteo Battilocchi, Inês M. Tomás, Clarisse Ganier, Sergi Garcia-Manyes, Fiona M. Watt
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Fast and accurate identification of plasmids and viruses in sequencing data using geNomad Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21
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Supervised discovery of interpretable gene programs from single-cell data Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Russell Z. Kunes, Thomas Walle, Max Land, Tal Nawy, Dana Pe’er
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A DNA nanodevice for mapping sodium at single-organelle resolution Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Junyi Zou, Koushambi Mitra, Palapuravan Anees, Daphne Oettinger, Joseph R. Ramirez, Aneesh Tazhe Veetil, Priyanka Dutta Gupta, Rajini Rao, Jayson J. Smith, Paschalis Kratsios, Yamuna Krishnan
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How lasers detect day-length changes of a few milliseconds Nature (IF 64.8) Pub Date : 2023-09-22
Device decades in the making senses very small alterations in Earth’s rotation.
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Earth’s average 2023 temperature is now likely to reach 1.5 °C of warming Nature (IF 64.8) Pub Date : 2023-09-22
But to breach the Paris agreement’s limit, the heating must be sustained for many years.
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Is depression lifting? AI that interprets brain waves has answers Nature (IF 64.8) Pub Date : 2023-09-22
A pattern of brain activity linked with recovery from severe depression could be used to improve therapies such as deep-brain stimulation
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AlphaFold touted as next big thing for drug discovery — but is it? Nature (IF 64.8) Pub Date : 2023-09-22
Questions remain about whether the AI tool for predicting protein structures can really shake up the pharmaceutical industry.
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Proposed law could protect academic freedom across Europe Nature (IF 64.8) Pub Date : 2023-09-22
Some European governments are tightening their political grip on universities, sparking calls for action.
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How to train your jellyfish: brainless box jellies learn from experience Nature (IF 64.8) Pub Date : 2023-09-22
Researchers have shown that the creatures can learn to avoid obstacles using visual and mechanical cues, despite not having a brain.
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Daily briefing: Critics call consciousness theory ‘pseudoscience’ Nature (IF 64.8) Pub Date : 2023-09-21
Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.
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Daily briefing: War and weather made Libya floods worse Nature (IF 64.8) Pub Date : 2023-09-18
Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.
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Decoding the building blocks of cellular processes from single-cell transcriptomics data Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21
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Precision RNA base editing with engineered and endogenous effectors Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Laura S. Pfeiffer, Thorsten Stafforst
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Identification of mobile genetic elements with geNomad Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Antonio Pedro Camargo, Simon Roux, Frederik Schulz, Michal Babinski, Yan Xu, Bin Hu, Patrick S. G. Chain, Stephen Nayfach, Nikos C. Kyrpides
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Detection of transcriptome-wide microRNA–target interactions in single cells with agoTRIBE Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Vaishnovi Sekar, Emilio Mármol-Sánchez, Panagiotis Kalogeropoulos, Laura Stanicek, Eduardo A. Sagredo, Albin Widmark, Evangelos Doukoumopoulos, Franziska Bonath, Inna Biryukova, Marc R. Friedländer
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Detecting organelle-specific activity of potassium channels with a DNA nanodevice Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-21 Palapuravan Anees, Anand Saminathan, Ezekiel R. Rozmus, Anke Di, Asrar B. Malik, Brian P. Delisle, Yamuna Krishnan
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Peptone: finding opportunity in disorder Nat. Biotechnol. (IF 46.9) Pub Date : 2023-09-19
Combining experimental and computational tools, this company is targeting disordered regions of proteins previously thought to be undruggable.
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Culture clashes: unpicking the power dynamics between research managers and academics Nature (IF 64.8) Pub Date : 2023-09-22
Some researchers thank admin colleagues with chocolates or wine. But deadline pressures, and the need to generate research income, can sometimes result in bullying.
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Vaccine specialist Peter Hotez: scientists are ‘under attack for someone else’s political gain’ Nature (IF 64.8) Pub Date : 2023-09-21
The physician-researcher who spoke out against misinformation during the COVID-19 pandemic says attacks against science are formidable — and getting worse.
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Furry little creatures teem with a multitude of viruses Nature (IF 64.8) Pub Date : 2023-09-20
Large-scale survey reveals the diversity of viruses in small mammals, which can be sources of viruses that hop to humans.
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World recommits to 2030 plan to save humanity — despite falling short so far Nature (IF 64.8) Pub Date : 2023-09-20
United Nations secretary-general António Guterres proposes US$500 billion annual stimulus package to meet the Sustainable Development Goals.
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Cingulate dynamics track depression recovery with deep brain stimulation Nature (IF 64.8) Pub Date : 2023-09-20 Sankaraleengam Alagapan, Ki Sueng Choi, Stephen Heisig, Patricio Riva-Posse, Andrea Crowell, Vineet Tiruvadi, Mosadoluwa Obatusin, Ashan Veerakumar, Allison C. Waters, Robert E. Gross, Sinead Quinn, Lydia Denison, Matthew O’Shaughnessy, Marissa Connor, Gregory Canal, Jungho Cha, Rachel Hershenberg, Tanya Nauvel, Faical Isbaine, Muhammad Furqan Afzal, Martijn Figee, Brian H. Kopell, Robert Butera, Helen
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Synthesis of portimines reveals the basis of their anti-cancer activity Nature (IF 64.8) Pub Date : 2023-09-20 Junchen Tang, Weichao Li, Tzu-Yuan Chiu, Francisco Martínez-Peña, Zengwei Luo, Christine T. Chong, Qijia Wei, Nathalia Gazaniga, Thomas J. West, Yi Yang See, Luke L. Lairson, Christopher G. Parker, Phil S. Baran
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Dual stem-cell populations interact in the skull Nature (IF 64.8) Pub Date : 2023-09-20 Andrei S. Chagin, Dana Trompet
Two types of stem cell produce similar progeny cells in the skull.
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How worlds are born: JWST reveals exotic chemistry of planetary nurseries Nature (IF 64.8) Pub Date : 2023-09-20
The telescope is delivering a cascade of insights about the ‘protoplanetary’ disks where planets take shape.
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Rich countries must align science funding with the SDGs Nature (IF 64.8) Pub Date : 2023-09-20
Research in poorer countries maps closely with the United Nations Sustainable Development Goals — wealthy nations must follow if the goals are to be met.
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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-19
Proceedings of the National Academy of Sciences, Volume 120, Issue 38, September 2023.
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Internal feedback in the cortical perception–action loop enables fast and accurate behavior Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-22 Jing Shuang Li, Anish A. Sarma, Terrence J. Sejnowski, John C. Doyle
Animals move smoothly and reliably in unpredictable environments. Models of sensorimotor control, drawing on control theory, have assumed that sensory information from the environment leads to actions, which then act back on the environment, creating a single, unidirectional perception–action loop. However, the sensorimotor loop contains internal delays in sensory and motor pathways, which can lead
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Signatures of Cooper pair dynamics and quantum-critical superconductivity in tunable carrier bands Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-22 Zhiyu Dong, Patrick A. Lee, Leonid S. Levitov
Different superconducting pairing mechanisms are markedly distinct in the underlying Cooper pair kinematics. Quantum-critical soft modes drive pairing interactions in which the pair scattering processes are highly collinear and can be classified into two categories: forward scattering and backscattering. Conversely, in conventional phonon mechanisms, Cooper pair scattering is of a generic noncollinear
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Measuring prion propagation in single bacteria elucidates a mechanism of loss Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-22 Krista Jager, Maria Teresa Orozco-Hidalgo, Benjamin Lennart Springstein, Euan Joly-Smith, Fotini Papazotos, EmilyKate McDonough, Eleanor Fleming, Giselle McCallum, Andy H. Yuan, Andreas Hilfinger, Ann Hochschild, Laurent Potvin-Trottier
Prions are self-propagating protein aggregates formed by specific proteins that can adopt alternative folds. Prions were discovered as the cause of the fatal transmissible spongiform encephalopathies in mammals, but prions can also constitute nontoxic protein-based elements of inheritance in fungi and other species. Prion propagation has recently been shown to occur in bacteria for more than a hundred
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A wireless, battery-free device enables oxygen generation and immune protection of therapeutic xenotransplants in vivo Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-22 Siddharth R. Krishnan, Claudia Liu, Matthew A. Bochenek, Suman Bose, Nima Khatib, Ben Walters, Laura O’Keeffe, Amanda Facklam, Robert Langer, Daniel G. Anderson
The immune isolation of cells within devices has the potential to enable long-term protein replacement and functional cures for a range of diseases, without requiring immune suppressive therapy. However, a lack of vasculature and the formation of fibrotic capsules around cell immune-isolating devices limits oxygen availability, leading to hypoxia and cell death in vivo. This is particularly problematic
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Scaphopoda is the sister taxon to Bivalvia: Evidence of ancient incomplete lineage sorting Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2023-09-22 Hao Song, Yunan Wang, Haojing Shao, Zhuoqing Li, Pinli Hu, Meghan K. Yap-Chiongco, Pu Shi, Tao Zhang, Cui Li, Yiguan Wang, Peizhen Ma, Jakob Vinther, Haiyan Wang, Kevin M. Kocot
The almost simultaneous emergence of major animal phyla during the early Cambrian shaped modern animal biodiversity. Reconstructing evolutionary relationships among such closely spaced branches in the animal tree of life has proven to be a major challenge, hindering understanding of early animal evolution and the fossil record. This is particularly true in the species-rich and highly varied Mollusca
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APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer Nat. Genet. (IF 30.8) Pub Date : 2023-09-21 Jennifer L. McCann, Agnese Cristini, Emily K. Law, Seo Yun Lee, Michael Tellier, Michael A. Carpenter, Chiara Beghè, Jae Jin Kim, Anthony Sanchez, Matthew C. Jarvis, Bojana Stefanovska, Nuri A. Temiz, Erik N. Bergstrom, Daniel J. Salamango, Margaret R. Brown, Shona Murphy, Ludmil B. Alexandrov, Kyle M. Miller, Natalia Gromak, Reuben S. Harris
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The oldest three-dimensionally preserved vertebrate neurocranium Nature (IF 64.8) Pub Date : 2023-09-20 Richard P. Dearden, Agnese Lanzetti, Sam Giles, Zerina Johanson, Andy S. Jones, Stephan Lautenschlager, Emma Randle, Ivan J. Sansom
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Getting inside the oldest known vertebrate skull Nature (IF 64.8) Pub Date : 2023-09-20 Zhikun Gai, Philip C. J. Donoghue
Evolutionary clues from analysis of a 458-million-year-old fossil.
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Consciousness theory slammed as ‘pseudoscience’ — sparking uproar Nature (IF 64.8) Pub Date : 2023-09-20
Researchers publicly call out theory that they say is not well supported by science, but that gets undue attention.
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‘They went to the bar at noon’: what this virtual AI village is teaching researchers Nature (IF 64.8) Pub Date : 2023-09-20
Researcher Joon Park talks about making a small town of AI-powered agents open-source.
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Sympathetic nerves suppress T-cell responses in infection and in cancer Nature (IF 64.8) Pub Date : 2023-09-20
Combination of beta-blockers and immune checkpoint blockade shrinks pancreatic tumours in mice.
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Changing old viticulture for all the right rieslings Nature (IF 64.8) Pub Date : 2023-09-20
Can the French wine industry, built on history and terroir, adapt fast enough to withstand climate change?
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Using CRISPR to study gene function aids understanding of 22q11.2 deletion syndrome Nature (IF 64.8) Pub Date : 2023-09-20
Innovative method for CRISPR screening in vivo provides insights into a syndrome caused by a chromosomal deletion.
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Daily briefing: World’s most powerful X-ray laser will ‘film’ electrical charges hopping around atoms Nature (IF 64.8) Pub Date : 2023-09-20
Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.
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The UK’s post-Brexit EU science deal: a graphical guide Nature (IF 64.8) Pub Date : 2023-09-20
Nature explores the United Kingdom and European Union’s research agreements, brokered through seven years of rollercoaster negotiations.
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Why does cancer spread to the spine? Newly discovered stem cells might be the key Nature (IF 64.8) Pub Date : 2023-09-20
Hear the biggest stories from the world of science | 20 September 2023
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These ancient whittled logs could be the earliest known wooden structure Nature (IF 64.8) Pub Date : 2023-09-20
Stacked timbers dated to roughly 476,000 years ago shows that ancient hominins worked with wood.
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Genetic modification can improve crop yields — but stop overselling it Nature (IF 64.8) Pub Date : 2023-09-20 Merritt Khaipho-Burch, Mark Cooper, Jose Crossa, Natalia de Leon, James Holland, Ramsey Lewis, Susan McCouch, Seth C. Murray, Ismail Rabbi, Pamela Ronald, Jeffrey Ross-Ibarra, Detlef Weigel, Edward S. Buckler
With a changing climate and a growing population, the world increasingly needs more-productive and resilient crops. But improving them requires a knowledge of what actually works in the field.
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India: neutralizing temptation by predatory journals Nature (IF 64.8) Pub Date : 2023-09-19
Letter to the Editor
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Tasmanian tiger RNA is first to be recovered from an extinct animal Nature (IF 64.8) Pub Date : 2023-09-19
Genetic sequences from a museum specimen offer fresh clues about the physiology of thylacines, which went extinct in the 1930s.
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Another reason to love remote working: it’s good for the planet Nature (IF 64.8) Pub Date : 2023-09-19
The more people do their jobs from home, the more they cut their greenhouse-gas emissions.
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The secret sex lives of ‘celibate’ stick insects Nature (IF 64.8) Pub Date : 2023-09-19
Genetic analysis shows that some stick insects that supposedly reproduce without sex are actually pairing off to have offspring.
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Bringing space rocks back to Earth could answer some of life’s biggest questions Nature (IF 64.8) Pub Date : 2023-09-19
Safe delivery of samples from an asteroid on 24 September will be the start of a global scientific journey — but similar missions need support.
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AI can help to speed up drug discovery — but only if we give it the right data Nature (IF 64.8) Pub Date : 2023-09-19 Marissa Mock, Suzanne Edavettal, Christopher Langmead, Alan Russell
Artificial-intelligence tools that enable companies to share data about drug candidates while keeping sensitive information safe can unleash the potential of machine learning and cutting-edge lab techniques, for the common good.
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Daily briefing: Alzheimer’s makes brain cells undergo ‘cellular suicide’ Nature (IF 64.8) Pub Date : 2023-09-19
Artificial intelligence diagnoses and predicts the risk of developing Parkinson’s disease, heart failure and more from images of a person’s retinas. Plus, a ‘Pandora’s box’ of new protein shapes has been discovered and why breast cancer often spreads to the spine.
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Why the pandemic treaty risks becoming COVID-19 groundhog day Nature (IF 64.8) Pub Date : 2023-09-19
Talks are stalling, but everyone benefits when the fruits of vaccine and drugs research are shared equitably.
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World’s most powerful X-ray laser will ‘film’ chemical reactions in unprecedented detail Nature (IF 64.8) Pub Date : 2023-09-18
Upgraded laser in California will produce one million X-ray pulses per second to study ultrafast processes at the atomic level.
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Nickelates join the club of high-temperature superconductors Nature (IF 64.8) Pub Date : 2023-09-18 Matthias Hepting
High-temperature superconductivity in a nickel-based compound.
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Waste product from wood finally used to make glue Nature (IF 64.8) Pub Date : 2023-09-18 Charles E. Frazier
How to make a wood adhesive from lignin.
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Recovery of walking after paralysis by regenerating characterized neurons to their natural target region Science (IF 56.9) Pub Date : 2023-09-21 Jordan W. Squair, Marco Milano, Alexandra de Coucy, Matthieu Gautier, Michael A. Skinnider, Nicholas D. James, Newton Cho, Anna Lasne, Claudia Kathe, Thomas H. Hutson, Steven Ceto, Laetitia Baud, Katia Galan, Viviana Aureli, Achilleas Laskaratos, Quentin Barraud, Timothy J. Deming, Richie E. Kohman, Bernard L. Schneider, Zhigang He, Jocelyne Bloch, Michael V. Sofroniew, Gregoire Courtine, Mark A. Anderson
Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulations to their natural target regions remains unclear. To address this question, we applied projection-specific and comparative single-nucleus RNA sequencing