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Thicker perineuronal nets disrupt insulin signalling Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-26 Sian Lewis
Diet-induced obesity in mice is accompanied by hypothalamic inflammation, which is shown here to result in thickened perineuronal nets in arcuate nucleus neurons, insulin resistance and metabolic disease.
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Safety in numbers Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-26 Sian Lewis
An anterior cingulate cortex to lateral septum circuit underlies the drive of spiny mice to affiliate with larger groups in preference to smaller ones.
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Concept cells and social memory: the abstract representation of familiar individuals Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-26 Teruhiro Okuyama
In this Journal club, Teruhiro Okuyama discusses the 2005 article that demonstrated the existence of ‘concept cells’ in the medial temporal lobe that show selective responses to specific individuals and play a key role in social memory.
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How witnessing distress alters resilience Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-26 Katherine Whalley
Mice that witness a cage mate’s distress become resilient to future adverse events as a result of altered serotonin release in the lateral habenula.
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The origins of freezing Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-10 Philip Tovote
Philip Tovote describes the 1980 paper in which Michael Fanselow systematically investigated freezing as a defensive response in rodents
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Neural control of gut regulatory T cells Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-03 Darran Yates
Activation of nociceptor neurons expressing TRPV1 downregulates gut regulatory T cells.
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Astrocyte antennae Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-03 Sian Lewis
Most astrocytes in the mouse brain have a primary cilium that transduces local cues to drive distinct astrocytic transcriptomic programmes that determine regional astrocytic subtypes, and, in turn, shape local circuits and influence behaviour.
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Mapping future locations Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-02 Katherine Whalley
Study identifies 'predictive grid cells' in the rat entorhinal cortex that encode projected future locations.
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Thyroid hormone modulates exploration circuits Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-02 Katherine Whalley
Thyroid hormone induces cortical circuit plasticity to modulate exploratory behaviours in mice.
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Disentangling human inference Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-09-02 Jake Rogers
A study in humans reveals that the hippocampus encodes relevant task variables in abstract format during inferential reasoning, which enables the generalization needed for such complex cognition.
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Advances in the labelling and selective manipulation of synapses Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-08-22 Binod Timalsina, Sangkyu Lee, Bong-Kiun Kaang
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Neuronal maturation and axon regeneration: unfixing circuitry to enable repair Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-08-20 Brett J. Hilton, Jarred M. Griffin, James W. Fawcett, Frank Bradke
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Reply to ‘The language network is topographically diverse and driven by rapid syntactic inferences’ Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-08-09 Evelina Fedorenko, Anna A. Ivanova, Tamar I. Regev
We thank Murphy and Woolnough for their comments on our recent Review (Fedorenko, E., Ivanova, A. A, & Regev, T. I. The language network as a natural kind within the broader landscape of the human brain. Nat. Rev. Neurosci. 25, 289–312; 2024)1, which we respond to below (Murphy, E. & Woolnough, O. The language network is topographically diverse and driven by rapid syntactic inferences. Nat. Rev. Neurosci
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The language network is topographically diverse and driven by rapid syntactic inferences Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-08-09 Elliot Murphy, Oscar Woolnough
In their timely Review article, Fedorenko and colleagues highlight how the posterior temporal cortex “may be the most critical and irreplaceable1” node of the language network (LN), a conclusion that we concur with (Fedorenko, E., Ivanova, A. A. & Regev, T. I. The language network as a natural kind within the broader landscape of the human brain. Nat. Rev. Neurosci. 25, 289–312; 2024)1. Here, we take
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Structure–function coupling in macroscale human brain networks Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-08-05 Panagiotis Fotiadis, Linden Parkes, Kathryn A. Davis, Theodore D. Satterthwaite, Russell T. Shinohara, Dani S. Bassett
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Circuit refinement without microglia Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-08-01 Darran Yates
A study finds that microglia depletion has no effect on experience-dependent maturation of visual cortex circuitry in mice.
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Multi-timescale neural dynamics for multisensory integration Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-08-01 Daniel Senkowski, Andreas K. Engel
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Psilocybin desynchronization persists in the human brain Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-31 Jake Rogers
Longitudinal precision functional mapping reveals that acute desynchronization of functional connectivity organization induced by the psychedelic psilocybin can persist long-term in the human brain.
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Variants in a noncoding gene drive prevalent neurodevelopmental disorder Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-29 Katherine Whalley
Two studies use large-scale genome sequencing data to identify variants in a noncoding gene that cause a neurodevelopmental syndrome in many individuals.
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Thirsty work for the cerebellum Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-24 Katherine Whalley
Cerebellar Purkinje neurons modulate thirst in mice
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Schizophrenia genomics: genetic complexity and functional insights Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-19 Patrick F. Sullivan, Shuyang Yao, Jens Hjerling-Leffler
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Publisher Correction: Macroscopic gradients of synaptic excitation and inhibition in the neocortex Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-16 Xiao-Jing Wang
Correction to: Nature Reviews Neuroscience https://doi.org/10.1038/s41583-020-0262-x, published online 6 February 2020.
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Neurogenic exacerbation of psoriasis Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-08 Darran Yates
Acid-sensing ion channel 3 in nociceptors exacerbates inflammation in psoriasis by inducing the release of calcitonin gene-related peptide from these neurons.
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Predicting natural behaviour by perturbation Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-02 Jake Rogers
A new modelling method developed in male Drosophila melanogaster maps how populations of neurons transform visual stimuli into courtship behaviours without recording neural activity.
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Mapping the cell-type-specific effects of ageing in the human cortex Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-01 Katherine Whalley
A study maps the effects of ageing and sex on gene regulation in specific human cortical cell types.
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Wrapping up reward Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-01 Sian Lewis
The maladaptive reward learning associated with morphine administration is shown here to be mediated by changes in dopamine-release dynamics in reward circuitry resulting from increased myelination specifically in the ventral tegmental area.
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Indirect neurogenesis in space and time Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-07-01 Stefan Thor
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Why so slow? Models of parkinsonian bradykinesia Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-27 David Williams
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Timescales of learning in prefrontal cortex Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-27 Jacob A. Miller, Christos Constantinidis
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Causal prominence for neuroscience Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-20 Philip Tseng, Tony Cheng
When is a causal system explanatory enough to be termed a ‘mechanism’? In their recent Review, Ross and Bassett argue that the term ‘mechanism’ in neuroscience suffers from a lack of clear, consistent definition across different studies and contexts (Ross, L. N. & Bassett, D. S. Causation in neuroscience: keeping mechanism meaningful. Nat. Rev. Neurosci. 25, 81–90; 2024)1. These authors recommend using
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Reply to ‘Causal prominence for neuroscience’ Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-20 Lauren N. Ross, Dani S. Bassett
In our recent Review (Ross, L. N. & Bassett, D. S. Causation in neuroscience: keeping mechanism meaningful. Nat. Rev. Neurosci. 25, 81–90; 2024)1, we suggest that the term mechanism lacks a clear and consistent definition across neuroscientific research. We outline challenges associated with the myriad meanings of this term, which guides grant and publication acceptances and remains viewed as a fundamental
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The power of direct observation: discovery of REM sleep Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-20 Danqian Liu
In this Journal Club, Danqian Liu describes the 1953 paper that reported the discovery of rapid eye movement (REM) sleep.
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Gene therapy for CNS disorders: modalities, delivery and translational challenges Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-19 Jingjing Gao, Swetharajan Gunasekar, Ziting (Judy) Xia, Kiruba Shalin, Christopher Jiang, Hao Chen, Dongtak Lee, Sohyung Lee, Nishkal D. Pisal, James N. Luo, Ana Griciuc, Jeffrey M. Karp, Rudolph Tanzi, Nitin Joshi
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Lessons on predictive learning from the honeybee Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-11 Sabine Krabbe
Sabine Krabbe describes a 1993 study of classical conditioning in the honeybee that provided early insights into the mechanisms of predictive learning.
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Reply to ‘Fear, anxiety and the functional architecture of the human central extended amygdala’ Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-10 Liping Wang, Yu-Ting Tseng, Bernhard Schaefke, Pengfei Wei, Sheng He
We thank Shackman et al. for their correspondence on our Review article (Tseng, Y. T., Schaefke, B., Wei, P. & Wang, L. Defensive responses: behaviour, the brain and the body. Nat. Rev. Neurosci. 24, 655–671; 2023)1, which raises interesting issues about the functional relationship between the human central nucleus of the amygdala (CeA) and the bed nucleus of the stria terminalis (BNST) (Shackman,
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Fear, anxiety and the functional architecture of the human central extended amygdala Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-10 Alexander J. Shackman, Shannon E. Grogans, Andrew S. Fox
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A pas de deux between the hippocampus and the cortex during sleep Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-05 Adrien Peyrache
In this Journal Club, Adrien Peyrache highlights a 1998 paper that showed memory formation as a dynamic process involving multiple brain areas.
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Pattern recognition using action potential timing Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-06-03 Izumi Fukunaga
In this Journal Club, Izumi Fukunaga discusses John Hopfield’s 1995 paper, which proposed a mechanism by which a continuously variable sensory stimulus can be transformed into a timing-based code.
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Common principles for odour coding across vertebrates and invertebrates Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-28 Kara A. Fulton, David Zimmerman, Aravi Samuel, Katrin Vogt, Sandeep Robert Datta
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The neuropathobiology of multiple sclerosis Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-24 Marcel S. Woo, Jan Broder Engler, Manuel A. Friese
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Network state transitions during cortical development Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-23 Michelle W. Wu, Nazim Kourdougli, Carlos Portera-Cailliau
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Brain functional networks and psychiatric disorders Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-17 Isobel Leake
Mendelian randomization analyses reveal potential causal associations between dysfunction of brain functional networks and psychiatric disorders.
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Mapping the social memory network Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-15 Maria Papatriantafyllou
Social memory enables animals to recognize familiar conspecifics and determines behaviours that are crucial for survival. Wang et al. now describe a neural circuit in mice that links the thalamic reticular nucleus (TRN) to social memory. Neuroanatomical and functional tracing identified cells of the parafascicular thalamic nucleus (PF) as the main postsynaptic targets of sTRNPvalb, and glutamatergic
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The speech neuroprosthesis Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-14 Alexander B. Silva, Kaylo T. Littlejohn, Jessie R. Liu, David A. Moses, Edward F. Chang
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Unravelling nature and nurture in cortical (re)organization Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-08 Tina T. Liu
In this Journal Club, Tina Liu describes a 1988 paper that revealed the capacity of the sensory cortex for functional reorganization
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Remapping revisited: how the hippocampus represents different spaces Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-07 André A. Fenton
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Stress drives seeking of starvation Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-05-02 Katherine Whalley
A subset of female mice that show anxiety-related traits seek out a starvation-like state when exposed to repeated stress
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Engram mechanisms of memory linking and identity Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-25 Ali Choucry, Masanori Nomoto, Kaoru Inokuchi
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Skill switching Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-25 Sian Lewis
The main direction of motor skill-specific information between rat primary motor cortex and dorsolateral striatum is shown to switch from cortex-predominant before learning to striatum-predominant after learning.
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The molecular determinants of microglial developmental dynamics Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-24 Liam Barry-Carroll, Diego Gomez-Nicola
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Attentional capture Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-15 Isobel Leake
A large network of brain regions is involved in salient distractor processing.
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The language network as a natural kind within the broader landscape of the human brain Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-12 Evelina Fedorenko, Anna A. Ivanova, Tamar I. Regev
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Key genes and convergent pathogenic mechanisms in Parkinson disease Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-10 Robert Coukos, Dimitri Krainc
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From compulsivity to compulsion: the neural basis of compulsive disorders Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-09 Trevor W. Robbins, Paula Banca, David Belin
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Natural primate neurobiology Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-04 Jake Rogers
A new study captures nearly the full repertoire of primate natural behaviour and reveals that highly distributed cortical activity maintains multifaceted dynamic social relationships.
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A structural role for SynGAP Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-04 Darran Yates
The synaptic protein SynGAP exerts its effects on synaptic plasticity via a structural role rather than its GTPase-activating protein activity.
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Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-04-04 Martin Kampmann
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mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-26 Teresa Ravizza, Mirte Scheper, Rossella Di Sapia, Jan Gorter, Eleonora Aronica, Annamaria Vezzani
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Coding corners Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-14 Katherine Whalley
Neurons in the mouse subiculum encode concave and convex geometrical environmental features.
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Barriers and brain fog Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-03-14 Sian Lewis
One of the long-term sequelae associated with SARS-CoV-2 infection is ‘brain fog’, which is shown in this study to be linked to systemic inflammation and leakiness of the blood–brain barrier.