-
An intriguing role of repeat-element RNAs in nerve injury repair Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-06-06 Sian Lewis
A polyA-tail-directed RNA sequencing approach that was used to investigate transcriptomic changes in dorsal root ganglia following nerve crush revealed unexpected upregulation of a specific set of B2-SINE transcriptional regulators that facilitate neuronal repair by co-ordinating axon transport and local translation.
-
Value-free teaching in action Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-06-06 Jake Rogers
Movement-related dopamine neuronal activity in the tail of the striatum encodes a value-free action prediction error that reinforces state-action associations, biasing mice to repeat past actions.
-
Inflammation alters cognition after cancer immunotherapy Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-29 Katherine Whalley
Neuroinflammatory mechanisms drive cognitive impairments in mice treated with chimeric antigen receptor (CAR)-T cell therapy.
-
Sleuthing subjectivity: a review of covert measures of consciousness Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-23 Sharif I. Kronemer, Peter A. Bandettini, Javier Gonzalez-Castillo
-
On analogies in vertebrate and insect visual systems Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-23 Ryosuke Tanaka, Ruben Portugues
-
Neuroferroptosis in health and diseases Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-19 Peng Lei, Tara Walker, Scott Ayton
-
Brain mechanisms underlying the inhibitory control of thought Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-16 Michael C. Anderson, Maite Crespo-Garcia, S. Subbulakshmi
-
Indigenous representation in neuroscience scholarship, teaching and care Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-16 Melissa L. Perreault, Rudi Taylor-Bragge, Hervé Chneiweiss, Andre D. McLachlan, T. Ryan Gregory, Roksana Khalid, Katherine Bassil, Anna Lydia Svalastog, Minerva R. Velarde, Judy Illes
Despite a global push to recognize Indigenous knowledge systems in research, neuroscience remains embedded in Euro-Western ways of means and methods. Authentic capacity-building will bring Indigenous ways of knowing and doing to the neuroscience workforce, to research and to training, and will lead to diversified and strengthened approaches to discovery and clinical care strategies.
-
Exploring the complexity of MECP2 function in Rett syndrome Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-13 Yi Liu, Troy W. Whitfield, George W. Bell, Ruisi Guo, Anthony Flamier, Richard A. Young, Rudolf Jaenisch
-
From avoidance to new action: the multifaceted role of the striatal indirect pathway Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-07 Jaeeon Lee, Bernardo L. Sabatini
-
Getting anxious about immune system activation Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-07 Sian Lewis
A possible mechanism for the increased incidence of mood disorders in people with immune system disorders such as psoriasis is revealed where, in mice, elevated serum levels of the cytokines IL-17A and IL-17C induce anxiety-like symptoms via activation of neurons in the anterior basolateral amygdala.
-
Functional diversity of amacrine cells Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-06 Darran Yates
A new study reveals over 40 functionally different types of amacrine cell in the mouse retina.
-
Dynorphin acts via a disinhibitory circuit mechanism Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-05-02 Jake Rogers
Dynorphin regulates motivated behaviour in mice via κ-opioid receptor signalling in a nucleus accumbens–ventral pallidum (VP) disinhibitory circuit that increases activity of VP cholinergic neurons projecting to the basolateral amygdala.
-
Interictal network dysfunction and cognitive impairment in epilepsy Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-04-28 Jennifer N. Gelinas, Dion Khodagholy
-
Brains in space: impact of microgravity and cosmic radiation on the CNS during space exploration Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-04-17 Floris L. Wuyts, Choi Deblieck, Charlot Vandevoorde, Marco Durante
-
Neural manifolds: more than the sum of their neurons Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-04-09 Juan Alvaro Gallego
In this Journal Club, Juan Gallego discusses a 2014 article that provided a first causal hint that neural manifolds may not only be a convenient way to interpret neural population activity.
-
Global coordination of brain activity by the breathing cycle Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-04-09 Adriano B. L. Tort, Diego A. Laplagne, Andreas Draguhn, Joaquin Gonzalez
-
Sculpting excitable membranes: voltage-gated ion channel delivery and distribution Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-04-02 Sidharth Tyagi, Grant P. Higerd-Rusli, Elizabeth J. Akin, Stephen G. Waxman, Sulayman D. Dib-Hajj
-
Dopamine signals threat-coping behaviour in threat–reward conflicts Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-04-02 Jake Rogers
A naturalistic threat–reward conflict reveals that dopamine dynamics in tail of the striatum in mice regulate not only avoidance of potential threats but also learning to overcome them.
-
Shaping preoptic-area neuronal diversity Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-03-31 Sian Lewis
The hypothalamic preoptic area is involved in numerous homeostatic and social behaviours, and the neurons of this area are shown in this study to consist of numerous subtypes that show diverse maturational profiles that correlate with periods of substantial behavioural change such as weaning and puberty.
-
Stopping speech on demand Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-03-26 Isobel Leake
A study provides evidence to support a previously unknown function of the premotor cortex in the inhibitory control of speech.
-
Autonomic dysfunction in neurodegenerative disease Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-03-26 Mara Mather
-
How microglia contribute to the induction and maintenance of neuropathic pain Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-03-24 Marzia Malcangio, George Sideris-Lampretsas
-
Disentangling sources of variability in decision-making Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-03-20 Jade S. Duffy, Mark A. Bellgrove, Peter R. Murphy, Redmond G. O’Connell
-
Musical neurodynamics Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-03-18 Eleanor E. Harding, Ji Chul Kim, Alexander P. Demos, Iran R. Roman, Parker Tichko, Caroline Palmer, Edward W. Large
-
How eating makes asthma worse Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-02-28 Sian Lewis
A possible mechanism underlying the worsening of asthma symptoms after eating is found in mice, where type 2 immunity in the lung (which is a primary driver of asthma) is found to be potentiated by food intake.
-
Sensory cortex quashes subcortical escape instinct Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-02-26 Jake Rogers
A modified looming paradigm teases apart how top-down cortical inputs from visual areas can override instinctive fear responses in mice via an endocannabinoid-mediated inhibitory plasticity mechanism in subcortical circuits.
-
Three systems of circuit formation: assembly, updating and tuning Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-02-24 Dániel L. Barabási, André Ferreira Castro, Florian Engert
-
Lipid metabolism, remodelling and intercellular transfer in the CNS Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-02-19 Sam Vanherle, Melanie Loix, Veronique E. Miron, Jerome J. A. Hendriks, Jeroen F. J. Bogie
-
Early spinal cord development: from neural tube formation to neurogenesis Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-02-06 Murielle Saade, Elisa Martí
-
Pathways to sex preferences Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-02-05 Katherine Whalley
A study explores the sexually dimorphic circuits that regulate sociosexual preferences in mice.
-
Human hippocampal circuit characterization Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-29 Darran Yates
A new study reveals distinct circuit features of the human hippocampal CA3 region.
-
The short and long pathways to memory Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-10 Darran Yates
Inhibition of CaMKII blocks short-term memory but not long-term memory of inhibitory avoidance in mice.
-
The curious case of dopaminergic prediction errors and learning associative information beyond value Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-08 Thorsten Kahnt, Geoffrey Schoenbaum
-
Circuit control of competition Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-07 Katherine Whalley
A study explores the circuits through which the dorsolateral prefrontal cortex orchestrates social competition in mice.
-
Schemas, reinforcement learning and the medial prefrontal cortex Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-07 Oded Bein, Yael Niv
-
Neural compositions use multigoal building blocks Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-07 Jake Rogers
A new study reveals an algorithm implemented by neurons in the medial frontal cortex that is involved in flexibly mapping appropriate actions during goal-oriented behaviour to novel situations.
-
Language is widely distributed throughout the brain Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-06 Linda Drijvers, Steven L. Small, Jeremy I. Skipper
Fedorenko and coauthors argue that language is localized to a small static set of brain regions, in a single segregated network (Fedorenko, E., Ivanova, A. A. & Regev, T. I. The language network as a natural kind within the broader landscape of the human brain. Nat. Rev. Neurosci. 25, 289–312; 2024)1. We challenge this traditional view of the neurobiology of language and argue that language is widely
-
Reply to ‘Language is widely distributed throughout the brain’ Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-06 Evelina Fedorenko, Anna A. Ivanova, Tamar I. Regev
-
Endothelial cells as key players in cerebral small vessel disease Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-02 Ronja Kremer, Anna Williams, Joanna Wardlaw
-
The brain’s action-mode network Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2025-01-02 Nico U. F. Dosenbach, Marcus E. Raichle, Evan M. Gordon
-
Reply to ‘The core language network separated from other networks during primate evolution’ Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-19 Evelina Fedorenko, Anna A. Ivanova, Tamar I. Regev
-
The core language network separated from other networks during primate evolution Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-19 Angela D. Friederici, Yannick Becker
-
When the ‘selfish’ brain and the ‘selfish’ immune system clash Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-18 Michaela Fencková
In this Journal Club, Michaela Fencková discusses a study published in 2020 that examined the effects of acute systemic inflammation on brain glucose metabolism in the context of delirium.
-
An unexpected role for macrophages in motor control Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-16 Sian Lewis
A population of macrophages has been found in muscle spindles that release glutamate, activate primary sensory afferents that are part of the stretch reflex, and have a role in regulating locomotion.
-
Publisher Correction: Structural neural plasticity evoked by rapid-acting antidepressant interventions Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-12 Clara Liao, Alisha N. Dua, Cassandra Wojtasiewicz, Conor Liston, Alex C. Kwan
-
Metastability demystified — the foundational past, the pragmatic present and the promising future Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-11 Fran Hancock, Fernando E. Rosas, Andrea I. Luppi, Mengsen Zhang, Pedro A. M. Mediano, Joana Cabral, Gustavo Deco, Morten L. Kringelbach, Michael Breakspear, J. A. Scott Kelso, Federico E. Turkheimer
-
Structurally informed models of directed brain connectivity Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-11 Matthew D. Greaves, Leonardo Novelli, Sina Mansour L., Andrew Zalesky, Adeel Razi
-
Remission from addiction: erasing the wrong circuits or making new ones? Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-11 Michel Engeln, Serge H. Ahmed
-
Understanding the molecular diversity of synapses Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-12-05 Marc van Oostrum, Erin M. Schuman
-
Targeting TYK2 to target tau Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-28 Caroline Barranco
Studies in human cell lines and transgenic mouse models show that non-receptor tyrosine-protein kinase TYK2 phosphorylates tau at Tyr29 and thereby promotes its stabilization and accumulation. In mice, knockdown of TYK2 reduced tau levels and attenuated tau neuropathology.
-
Structural MRI of brain similarity networks Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-28 Isaac Sebenius, Lena Dorfschmidt, Jakob Seidlitz, Aaron Alexander-Bloch, Sarah E. Morgan, Edward Bullmore
-
Neural circuit basis of pathological anxiety Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-27 Teddy J. Akiki, Jenna Jubeir, Claire Bertrand, Leonardo Tozzi, Leanne M. Williams
-
Echolocation over long distances Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-26 Michael Attwaters
Bats use echolocation to navigate long distances without relying on other sensory information.
-
An interoceptive circuit regulating energy balance Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-26 Sian Lewis
Interoceptive, feeding-related inputs are integrated by BDNF-expressing neurons in the ventromedial hypothalamus that project to the brainstem and regulate food intake and feeding-associated jaw movements.
-
Ruminating on replay during the awake state Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-20 Anna K. Gillespie
In this Journal Club, Anna Gillespie discusses how the discovery of hippocampal replay during the awake state reshaped our understanding of its role in memory function.
-
Structural neural plasticity evoked by rapid-acting antidepressant interventions Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-18 Clara Liao, Alisha N. Dua, Cassandra Wojtasiewicz, Conor Liston, Alex C. Kwan
-
Innate immune control of synapse development Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-18 Katherine Whalley
Innate lymphoid cells regulate inhibitory synapse formation in the mouse cortex during early postnatal life.
-
Issues of parcellation in the calculation of structure–function coupling Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-14 Adam Turnbull, Feng Vankee Lin, Zhengwu Zhang
In their recent Review, Fotiadis and colleagues expertly summarized recent research on structure–function coupling (SFC), a neural marker representing the correspondence between structural and functional neural connections (Fotiadis, P. et al. Structure–function coupling in macroscale human brain networks. Nat. Rev. Neurosci. 25, 688–704; 2024)1. They outlined how this marker is important for understanding
-
Reply to ‘Issues of parcellation in the calculation of structure–function coupling’ Nat. Rev. Neurosci. (IF 28.7) Pub Date : 2024-11-14 Panagiotis Fotiadis, Dani S. Bassett
We appreciate the thoughtful Correspondence from A. Turnbull, F. V. Lin and Z. Zhang about our recent Review (Fotiadis, P. et al. Structure–function coupling in macroscale human brain networks. Nat. Rev. Neurosci. 25, 688–704; 2024)1, in which we synthesized recent work assessing the dynamic relationship between structural and functional connectivity in the human brain, commonly referred to as structure–function