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Nuclear SREBP2 condensates regulate the transcriptional activation of lipogenic genes and cholesterol homeostasis Nat. Metab. (IF 18.9) Pub Date : 2025-05-20 Mengqiang Xu, Shi-You Jiang, Shuocheng Tang, Meimei Zhu, Yueer Hu, Juewan Li, Jizhi Yan, Chenyang Qin, Dongxia Tan, Yang An, Yuxiu Qu, Bao-Liang Song, Hanhui Ma, Wei Qi
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Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging of 13C-labelled glucose metabolism Nat. Metab. (IF 18.9) Pub Date : 2025-05-19 Anastasia Tsyben, Andreas Dannhorn, Gregory Hamm, Manthos Pitoulias, Dominique-Laurent Couturier, Ashley Sawle, Mayen Briggs, Alan J. Wright, Cara Brodie, Lee Mendil, Jodi L. Miller, Eleanor C. Williams, Lovisa Franzén, Grand De Jong, Tannia Gracia, Fani Memi, Omer Ali Bayraktar, Ram Adapa, Jyotsna Rao, Ariadna González-Fernández, Josephine Bunch, Zoltan Takats, Simon T. Barry, Richard J. A. Goodwin
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Mechanically sensitive MAPK signalling mediates resistance exercise-induced muscle growth Nat. Metab. (IF 18.9) Pub Date : 2025-05-15 Sue C. Bodine, Craig A. Goodman
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Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth Nat. Metab. (IF 18.9) Pub Date : 2025-05-15 Wenyuan G. Zhu, Aaron C. Q. Thomas, Gary M. Wilson, Chris McGlory, Jamie E. Hibbert, Corey GK. Flynn, Ramy K. A. Sayed, Hector G. Paez, Marius Meinhold, Kent W. Jorgenson, Jae-Sung You, Nathaniel D. Steinert, Kuan-Hung Lin, Martin J. MacInnis, Joshua J. Coon, Stuart M. Phillips, Troy A. Hornberger
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Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution Nat. Metab. (IF 18.9) Pub Date : 2025-05-13 Anne Loft, Margo P. Emont, Ada Weinstock, Adeline Divoux, Adhideb Ghosh, Allon Wagner, Ann V. Hertzel, Babukrishna Maniyadath, Bart Deplancke, Boxiang Liu, Camilla Scheele, Carey Lumeng, Changhai Ding, Chenkai Ma, Christian Wolfrum, Clarissa Strieder-Barboza, Congru Li, Danh D. Truong, David A. Bernlohr, Elisabet Stener-Victorin, Erin E. Kershaw, Esti Yeger-Lotem, Farnaz Shamsi, Hannah X. Hui, Henrique
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Metabolic reprogramming of interleukin-17-producing γδ T cells promotes ACC1-mediated de novo lipogenesis under psoriatic conditions Nat. Metab. (IF 18.9) Pub Date : 2025-05-13 Yu-San Kao, Mario Lauterbach, Aleksandra Lopez Krol, Ute Distler, Gloria Janet Godoy, Matthias Klein, Rafael Jose Argüello, Fatima Boukhallouk, Sara Vallejo Fuente, Kathrin Luise Braband, Assel Nurbekova, Monica Romero, Panagiota Mamareli, Luana Silva, Luis Eduardo Alves Damasceno, Francesca Rampoldi, Luciana Berod, Lydia Lynch, Karsten Hiller, Tim Sparwasser
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Nicotinamide modulates gut microbial metabolic potential and accelerates recovery in mild-to-moderate COVID-19 Nat. Metab. (IF 18.9) Pub Date : 2025-05-12 Stefan Schreiber, Georg H. Waetzig, Víctor A. López-Agudelo, Corinna Geisler, Kristina Schlicht, Sina Franzenburg, Romina di Giuseppe, Daniel Pape, Thomas Bahmer, Michael Krawczak, Elisabeth Kokott, Josef M. Penninger, Oliver Harzer, Jan Kramer, Tammo von Schrenck, Felix Sommer, Helena U. Zacharias, Belén Millet Pascual-Leone, Sofia K. Forslund, Jan Heyckendorf, Konrad Aden, Regina Hollweck, Matthias
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The gut microbiome and cancer: from tumorigenesis to therapy Nat. Metab. (IF 18.9) Pub Date : 2025-05-06 Amandine Nobels, Cédric van Marcke, Bénédicte F. Jordan, Matthias Van Hul, Patrice D. Cani
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Neuronal CCL2 responds to hyperglycaemia and contributes to anxiety disorders in the context of diabetes Nat. Metab. (IF 18.9) Pub Date : 2025-05-06 Kaijun Pan, Yanan Gao, Haichao Zong, Yongmei Zhang, Yingbei Qi, Hanlin Wang, Wengang Chen, Ting Zhou, Jinwen Zhao, Tao Yin, Haoran Guo, Min Wang, Hanmin Wang, Tao Pang, Yi Zang, Jia Li
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NAD kinase essentiality in cancer: in real life, it is all about folates Nat. Metab. (IF 18.9) Pub Date : 2025-05-02 Petra Marttila, Johannes Meiser
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Cytosolic NADK is conditionally essential for folate-dependent nucleotide synthesis Nat. Metab. (IF 18.9) Pub Date : 2025-05-02 Kyle M. Flickinger, Carlos A. Mellado Fritz, Kimberly S. Huggler, Gina M. Wade, Gavin R. Chang, Kathryn C. Fox, Judith A. Simcox, Jason R. Cantor
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Unravelling the GIPR agonist versus antagonist paradox Nat. Metab. (IF 18.9) Pub Date : 2025-04-29 Alice E. Adriaenssens
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GIPR agonism and antagonism decrease body weight and food intake via different mechanisms in male mice Nat. Metab. (IF 18.9) Pub Date : 2025-04-29 Robert M. Gutgesell, Ahmed Khalil, Arkadiusz Liskiewicz, Gandhari Maity-Kumar, Aaron Novikoff, Gerald Grandl, Daniela Liskiewicz, Callum Coupland, Ezgi Karaoglu, Seun Akindehin, Russell Castelino, Fabiola Curion, Xue Liu, Cristina Garcia-Caceres, Alberto Cebrian-Serrano, Jonathan D. Douros, Patrick J. Knerr, Brian Finan, Richard D. DiMarchi, Kyle W. Sloop, Ricardo J. Samms, Fabian J. Theis, Matthias
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GIPR-Ab/GLP-1 peptide–antibody conjugate requires brain GIPR and GLP-1R for additive weight loss in obese mice Nat. Metab. (IF 18.9) Pub Date : 2025-04-29 Clarissa M. Liu, Elizabeth A. Killion, Rola Hammoud, Shu-Chen Lu, Renee Komorowski, Tongyu Liu, Matt Kanke, Veena A. Thomas, Kevin Cook, Glenn N. Sivits, Aerielle B. Ben, Larissa I. Atangan, Rajaa Hussien, Amy Tang, Artem Shkumatov, Chi-Ming Li, Daniel J. Drucker, Murielle M. Véniant
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Intracellular metabolic gradients dictate dependence on exogenous pyruvate Nat. Metab. (IF 18.9) Pub Date : 2025-04-28 Benjamin T. Jackson, Angela M. Montero, Sangita Chakraborty, Julia S. Brunner, Paige K. Arnold, Anna E. Bridgeman, Pavlina K. Todorova, Katrina I. Paras, Lydia W. S. Finley
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Starvation induces metabolic hepatocyte reprogramming Nat. Metab. (IF 18.9) Pub Date : 2025-04-25 Coenraad F. Slabber, Jan S. Tchorz
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Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states Nat. Metab. (IF 18.9) Pub Date : 2025-04-25 Junichi Okada, Austin Landgraf, Alus M. Xiaoli, Li Liu, Maxwell Horton, Victor L. Schuster, Fajun Yang, Simone Sidoli, Yunping Qiu, Irwin J. Kurland, Carolina Eliscovich, Kosaku Shinoda, Jeffrey E. Pessin
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Mind over microbiota: neurons call the shots in the gut Nat. Metab. (IF 18.9) Pub Date : 2025-04-22 Wuling Zhong, Karen Wang, Amir Zarrinpar
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Rapid modulation of gut microbiota composition by hypothalamic circuits in mice Nat. Metab. (IF 18.9) Pub Date : 2025-04-22 Míriam Toledo, Sara Martínez-Martínez, Matthias Van Hul, Berta Laudo, Elena Eyre, Rudy Pelicaen, Anthony Puel, Jordi Altirriba, Alicia G. Gómez-Valadés, Julica Inderhees, Isabel Moreno-Indias, Macarena Pozo, Iñigo Chivite, Maria Milà-Guasch, Roberta Haddad-Tóvolli, Arnaud Obri, Júlia Fos-Domènech, Iasim Tahiri, Sergio R. Llana, Sara Ramírez, Erika Monelli, Markus Schwaninger, Patrice D. Cani, Rubén
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Career pathways, part 17 Nat. Metab. (IF 18.9) Pub Date : 2025-04-21 Leah Gates, Benjamin P. Weaver
Leah Gates and Ben Weaver reflect on how overcoming different hurdles and dealing with unexpected events has ultimately shaped their careers. They also emphasize the importance of relying on a strong support network.
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Itaconate boosts type I IFN response by disrupting cytoprotection Nat. Metab. (IF 18.9) Pub Date : 2025-04-18 Theresa Ramalho, Ricardo Tostes Gazzinelli
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Itaconate modulates immune responses via inhibition of peroxiredoxin 5 Nat. Metab. (IF 18.9) Pub Date : 2025-04-18 Tomas Paulenda, Barbora Echalar, Lucie Potuckova, Veronika Vachova, Denis A. Kleverov, Johannes Mehringer, Ekaterina Potekhina, Alex Jacoby, Devashish Sen, Chris Nelson, Rick Stegeman, Vladimir Sukhov, Danielle Kemper, Cheryl F. Lichti, Nicholas J. Day, Tong Zhang, Kamila Husarcikova, Monika Bambouskova, Daved H. Fremont, Wei-jun Qian, Sergej Djuranovic, Slavica Pavlovic-Djuranovic, Vsevolod V. Belousov
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Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice Nat. Metab. (IF 18.9) Pub Date : 2025-04-16 Ying Liu, Ezequiel Dantas, Miriam Ferrer, Ting Miao, Mujeeb Qadiri, Yifang Liu, Aram Comjean, Emma E. Davidson, Tiffany Perrier, Tanvir Ahmed, Yanhui Hu, Marcus D. Goncalves, Tobias Janowitz, Norbert Perrimon
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Signalling from adipose tissue to the brain is not just about leptin Nat. Metab. (IF 18.9) Pub Date : 2025-04-15 Peter Arner
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GDF15 links adipose tissue lipolysis with anxiety Nat. Metab. (IF 18.9) Pub Date : 2025-04-15 Logan K. Townsend, Dongdong Wang, Carly M. Knuth, Russta Fayyazi, Ahmad Mohammad, Léa J. Becker, Evangelia E. Tsakiridis, Eric M. Desjardins, Zeel Patel, Celina M. Valvano, Junfeng Lu, Alice E. Payne, Ofure Itua, Kyle D. Medak, Daniel M. Marko, Jonathan D. Schertzer, David C. Wright, Shawn M. Beaudette, Katherine M. Morrison, André C. Carpentier, Denis P. Blondin, Rebecca E. K. MacPherson, Jordan G
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A gut hormone governing protein appetite and longevity Nat. Metab. (IF 18.9) Pub Date : 2025-04-14 Chisako Sakuma, Fumiaki Obata
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Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan Nat. Metab. (IF 18.9) Pub Date : 2025-04-14 Nadja Ahrentløv, Olga Kubrak, Mette Lassen, Alina Malita, Takashi Koyama, Amalie S. Frederiksen, Casper M. Sigvardsen, Alphy John, Pernille E. H. Madsen, Kenneth V. Halberg, Stanislav Nagy, Cordelia Imig, Erik A. Richter, Michael J. Texada, Kim Rewitz
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The art of war: burning stores to fuel anti-viral immunity Nat. Metab. (IF 18.9) Pub Date : 2025-04-11 Sarah Q. Crome, Sue Tsai
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NK cell-derived IFNγ mobilizes free fatty acids from adipose tissue to promote early B cell activation during viral infection Nat. Metab. (IF 18.9) Pub Date : 2025-04-11 Mia Krapić, Inga Kavazović, Sanja Mikašinović, Karlo Mladenić, Fran Krstanović, Gönül Seyhan, Sabine Helmrath, Elena Camerini, Ilija Brizić, Fleur S. Peters, Marc Schmidt-Supprian, Bojan Polić, Tamara Turk Wensveen, Felix M. Wensveen
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Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics Nat. Metab. (IF 18.9) Pub Date : 2025-04-10 Kil Sun Lee, Xiaoyang Su, Tao Huan
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Incretin-based therapeutics for the treatment of neurodegenerative diseases Nat. Metab. (IF 18.9) Pub Date : 2025-04-10 Anika Vear, Michael T. Heneka, Christoffer Clemmensen
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Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice Nat. Metab. (IF 18.9) Pub Date : 2025-04-10 Meng Yu, Bing Feng, Jonathan C. Bean, Qianru Zhao, Yongjie Yang, Hailan Liu, Yongxiang Li, Benjamin P. Eappen, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Xi Chen, Na Yin, Darah Ave Threat, Nathan Xu, Junying Han, Peiyu Gao, Yi Zhu, Darryl L. Hadsell, Yang He, Pingwen Xu, Yanlin He, Chunmei Wang
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UPRmt controls the mesenchymal-to-epithelial transition Nat. Metab. (IF 18.9) Pub Date : 2025-04-09 Marine Barthez, Danica Chen
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The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming Nat. Metab. (IF 18.9) Pub Date : 2025-04-09 Zhongfu Ying, Yanmin Xin, Zihuang Liu, Tianxin Tan, Yile Huang, Yingzhe Ding, Xuejun Hong, Qiuzhi Li, Chong Li, Jingyi Guo, Gaoshen Liu, Qi Meng, Shihe Zhou, Wenxin Li, Yao Yao, Ge Xiang, Linpeng Li, Yi Wu, Yang Liu, Miaohui Mu, Zifeng Ruan, Wenxi Liang, Junwei Wang, Yaofeng Wang, Baojian Liao, Yang Liu, Wuming Wang, Gang Lu, Dajiang Qin, Duanqing Pei, Wai-Yee Chan, Xingguo Liu
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TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux Nat. Metab. (IF 18.9) Pub Date : 2025-04-08 Joanne F. Garbincius, Oniel Salik, Henry M. Cohen, Carmen Choya-Foces, Adam S. Mangold, Angelina D. Makhoul, Anna E. Schmidt, Dima Y. Khalil, Joshua J. Doolittle, Anya S. Wilkinson, Emma K. Murray, Michael P. Lazaropoulos, Alycia N. Hildebrand, Dhanendra Tomar, John W. Elrod
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Intergenerational metabolic effects of cold exposure Nat. Metab. (IF 18.9) Pub Date : 2025-04-07 R. Teperino
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Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans Nat. Metab. (IF 18.9) Pub Date : 2025-04-07 Takeshi Yoneshiro, Mami Matsushita, Sayuri Fuse-Hamaoka, Miyuki Kuroiwa, Yuko Kurosawa, Yosuke Yamada, Makoto Arai, Yuchen Wei, Makoto Iida, Kenichi Kuma, Toshimitsu Kameya, Tomoya Harada, Yoshihiro Matsumura, Tsuyoshi Osawa, Yoshiko Aoki, Hisashi Nakamura, Takafumi Hamaoka, Juro Sakai, Masayuki Saito
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Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia Nat. Metab. (IF 18.9) Pub Date : 2025-04-04 Snehal N. Chaudhari, Yingjia Chen, Rafael Ferraz-Bannitz, Cameron Cummings, Amanda Sheehan, Pilar Casanova Querol, Berkcan Ozturk, Hanna Wang, Gabriel D’Agostino, Fei Ye, Eric G. Sheu, A. Sloan Devlin, Mary-Elizabeth Patti
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The emerging role of protein l-lactylation in metabolic regulation and cell signalling Nat. Metab. (IF 18.9) Pub Date : 2025-04-02 Haowen Ren, Yuwei Tang, Di Zhang
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Publisher Correction: A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis Nat. Metab. (IF 18.9) Pub Date : 2025-04-01 Yiqiong Liu, Ying Wang, Zheng-dong Zhao, Guoguang Xie, Chao Zhang, Renchao Chen, Yi Zhang
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Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights Nat. Metab. (IF 18.9) Pub Date : 2025-03-26 Sandhya P. Chakravartti, Kay Jann, Ralf Veit, Hanyang Liu, Alexandra G. Yunker, Brendan Angelo, John R. Monterosso, Anny H. Xiang, Stephanie Kullmann, Kathleen A. Page
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Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue Nat. Metab. (IF 18.9) Pub Date : 2025-03-25 Dylan J. Duerre, Julia K. Hansen, Steven V. John, Annie Jen, Noah D. Carrillo, Hoang Bui, Yutong Bao, Matias Fabregat, J. Leon Catrow, Li-Yu Chen, Katherine A. Overmyer, Evgenia Shishkova, Quentinn Pearce, Mark P. Keller, Richard A. Anderson, Vincent L. Cryns, Alan D. Attie, James E. Cox, Joshua J. Coon, Jing Fan, Andrea Galmozzi
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Reversible reduction in brain myelin content after endurance exercise Nat. Metab. (IF 18.9) Pub Date : 2025-03-24
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Reversible reduction in brain myelin content upon marathon running Nat. Metab. (IF 18.9) Pub Date : 2025-03-24 Pedro Ramos-Cabrer, Alberto Cabrera-Zubizarreta, Daniel Padro, Mario Matute-González, Alfredo Rodríguez-Antigüedad, Carlos Matute
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Author Correction: Metagenomic estimation of dietary intake from human stool. Nat. Metab. (IF 18.9) Pub Date : 2025-03-01 Christian Diener,Hannah D Holscher,Klara Filek,Karen D Corbin,Christine Moissl-Eichinger,Sean M Gibbons
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Vestibular nucleus mediation of motion sickness has implications for obesity control Nat. Metab. (IF 18.9) Pub Date : 2025-03-21
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Vestibular neurons link motion sickness, behavioural thermoregulation and metabolic balance in mice Nat. Metab. (IF 18.9) Pub Date : 2025-03-21 Longlong Tu, Xing Fang, Yongjie Yang, Meng Yu, Hailan Liu, Hesong Liu, Na Yin, Jonathan C. Bean, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Olivia Z. Ginnard, Qingzhuo Liu, Yuhan Shi, Junying Han, Yi Zhu, Makoto Fukuda, Qingchun Tong, Benjamin Arenkiel, Mingshan Xue, Yang He, Chunmei Wang, Yong Xu
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GLP-2 attenuates antipsychotics’ adverse metabolic effects Nat. Metab. (IF 18.9) Pub Date : 2025-03-20 Sandra Pereira, Margaret K. Hahn
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GLP-2 prevents antipsychotics-induced metabolic dysfunction in mice Nat. Metab. (IF 18.9) Pub Date : 2025-03-20 Yanmin Peng, Chenzhang Feng, Shiyu Peng, Ying Wang, Qian Zhang, Zhuolei Jiao, Huateng Cao, Shajin Huang, Peihuang Tian, Xiujia Sun, Xiaohong Xu, Yu Fu, Ji Hu, Zhe Zhang
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AI-driven framework to map the brain metabolome in three dimensions Nat. Metab. (IF 18.9) Pub Date : 2025-03-18 Xin Ma, Cameron J. Shedlock, Terrymar Medina, Roberto A. Ribas, Harrison A. Clarke, Tara R. Hawkinson, Praveen K. Dande, Hari K. R. Golamari, Lei Wu, Borhane EC. Ziani, Sara N. Burke, Matthew E. Merritt, Craig W. Vander Kooi, Matthew S. Gentry, Nirbhay N. Yadav, Li Chen, Ramon C. Sun
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The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research Nat. Metab. (IF 18.9) Pub Date : 2025-03-17 Shaunak Deota, Julie S. Pendergast, Ullas Kolthur-Seetharam, Karyn A. Esser, Frédéric Gachon, Gad Asher, Charna Dibner, Salvador Aznar Benitah, Carolina Escobar, Deborah M. Muoio, Eric Erquan Zhang, Gökhan S. Hotamışlıgil, Joseph Bass, Joseph S. Takahashi, Joshua D. Rabinowitz, Katja A. Lamia, Rafael de Cabo, Shingo Kajimura, Valter D. Longo, Ying Xu, Mitchell A. Lazar, Eric Verdin, Juleen R. Zierath
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SIRT5 slows skeletal muscle ageing by alleviating inflammation Nat. Metab. (IF 18.9) Pub Date : 2025-03-14 Vera Gorbunova, Andrei Seluanov
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SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1 Nat. Metab. (IF 18.9) Pub Date : 2025-03-14 Qian Zhao, Ying Jing, Xiaoyu Jiang, Xin Zhang, Feifei Liu, Haoyan Huang, Zhihua Zhang, Haijun Wang, Shuhui Sun, Shuai Ma, Weiqi Zhang, Yang Yu, Xiaobing Fu, Guoguang Zhao, Jing Qu, Si Wang, Guang-Hui Liu
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The cyclic metabolic switching theory of intermittent fasting Nat. Metab. (IF 18.9) Pub Date : 2025-03-14 Mark P. Mattson
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Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control Nat. Metab. (IF 18.9) Pub Date : 2025-03-14 Zengliang Jiang, Liuqing He, Diyin Li, Laibao Zhuo, Lingjun Chen, Rui-Qi Shi, Jianhua Luo, Yuhui Feng, Yuhui Liang, Danyang Li, Xiao Congmei, Yuanqing Fu, Yu-ming Chen, Ju-Sheng Zheng, Liang Tao
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More protein in ultra-processed foods: no shortcut to eating less Nat. Metab. (IF 18.9) Pub Date : 2025-03-13 Rikard Landberg, Therese Karlsson
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Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance Nat. Metab. (IF 18.9) Pub Date : 2025-03-13 Franziska A. Hägele, Catrin Herpich, Jana Koop, Jonas Grübbel, Rebecca Dörner, Svenja Fedde, Oliver Götze, Yves Boirie, Manfred J. Müller, Kristina Norman, Anja Bosy-Westphal
更新日期：2025-04-29
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