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Every islet matters: improving the impact of human islet research Nat. Metab. (IF 19.865) Pub Date : 2022-08-11 Anna L. Gloyn, Mark Ibberson, Piero Marchetti, Alvin C. Powers, Patrik Rorsman, Maike Sander, Michele Solimena
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Introducing the Lipidomics Minimal Reporting Checklist Nat. Metab. (IF 19.865) Pub Date : 2022-08-08 Jeffrey G. McDonald, Christer S. Ejsing, Dominik Kopczynski, Michal Holčapek, Junken Aoki, Makoto Arita, Masanori Arita, Erin S. Baker, Justine Bertrand-Michel, John A. Bowden, Britta Brügger, Shane R. Ellis, Maria Fedorova, William J. Griffiths, Xianlin Han, Jürgen Hartler, Nils Hoffmann, Jeremy P. Koelmel, Harald C. Köfeler, Todd W. Mitchell, Valerie B. O’Donnell, Daisuke Saigusa, Dominik Schwudke
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Career pathways, part 9 Nat. Metab. (IF 19.865) Pub Date : 2022-08-05 Evanna L. Mills, Edward T. Chouchani
Evanna Mills and Edward Chouchani share the experience of their successful mentor–mentee relationship and talk about the challenges of starting a new lab — both from a recent perspective and five years on.
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Systemic induction of senescence in young mice after single heterochronic blood exchange Nat. Metab. (IF 19.865) Pub Date : 2022-07-28 Ok Hee Jeon, Melod Mehdipour, Tae-Hwan Gil, Minha Kang, Nicholas W. Aguirre, Zachery R. Robinson, Cameron Kato, Jessy Etienne, Hyo Gyeong Lee, Fatouma Alimirah, Vighnesh Walavalkar, Pierre-Yves Desprez, Michael J. Conboy, Judith Campisi, Irina M. Conboy
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Prolonged lactation benefits offspring metabolism Nat. Metab. (IF 19.865) Pub Date : 2022-07-25 Elisa Félix-Soriano, Kristin I. Stanford
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Neurometabolism in focus Nat. Metab. (IF 19.865) Pub Date : 2022-07-25
A better understanding of how the brain controls whole-body energy use and storage, as well as eating behaviour, will pave the way for improving therapeutics to fight metabolic diseases. This Focus presents a collection of Reviews, Perspectives and research Articles that integrate the most recent evidence on how the brain controls key aspects of whole-body metabolism.
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Sensing of the non-essential amino acid tyrosine governs the response to protein restriction in Drosophila Nat. Metab. (IF 19.865) Pub Date : 2022-07-25 Hina Kosakamoto, Naoki Okamoto, Hide Aikawa, Yuki Sugiura, Makoto Suematsu, Ryusuke Niwa, Masayuki Miura, Fumiaki Obata
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Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis Nat. Metab. (IF 19.865) Pub Date : 2022-07-25 Sreekala Nampoothiri, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
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Hindbrain circuits in the control of eating behaviour and energy balance Nat. Metab. (IF 19.865) Pub Date : 2022-07-25 Wenwen Cheng, Desiree Gordian, Mette Q. Ludwig, Tune H. Pers, Randy J. Seeley, Martin G. Myers
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Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding Nat. Metab. (IF 19.865) Pub Date : 2022-07-25 Ivan C. Alcantara, Ana Pamela Miranda Tapia, Yeka Aponte, Michael J. Krashes
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Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21 Nat. Metab. (IF 19.865) Pub Date : 2022-07-25 Veronica Pena-Leon, Cintia Folgueira, Silvia Barja-Fernández, Raquel Pérez-Lois, Natália Da Silva Lima, Marion Martin, Violeta Heras, Sara Martinez-Martinez, Paola Valero, Cristina Iglesias, Mannon Duquenne, Omar Al-Massadi, Daniel Beiroa, Yara Souto, Miguel Fidalgo, Rasika Sowmyalakshmi, Diana Guallar, Juan Cunarro, Cecilia Castelao, Ana Senra, Patricia González-Saenz, Rocío Vázquez-Cobela, Rosaura
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TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages Nat. Metab. (IF 19.865) Pub Date : 2022-07-21 Ev-Marie Schuster, Maximilian W. Epple, Katharina M. Glaser, Michael Mihlan, Kerstin Lucht, Julia A. Zimmermann, Anna Bremser, Aikaterini Polyzou, Nadine Obier, Nina Cabezas-Wallscheid, Eirini Trompouki, Andrea Ballabio, Jörg Vogel, Joerg M. Buescher, Alexander J. Westermann, Angelika S. Rambold
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Mitochondrial heterogeneity and homeostasis through the lens of a neuron Nat. Metab. (IF 19.865) Pub Date : 2022-07-11 Gulcin Pekkurnaz, Xinnan Wang
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Methanol-tolerant yeast for biofuel production Nat. Metab. (IF 19.865) Pub Date : 2022-07-11 Eun Yeol Lee, Arslan Sarwar
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Sun exposure stimulates appetite in males Nat. Metab. (IF 19.865) Pub Date : 2022-07-11 Carlos Dieguez, Ruben Nogueiras
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Rescuing yeast from cell death enables overproduction of fatty acids from sole methanol Nat. Metab. (IF 19.865) Pub Date : 2022-07-11 Jiaoqi Gao, Yunxia Li, Wei Yu, Yongjin J. Zhou
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Food-seeking behavior is triggered by skin ultraviolet exposure in males Nat. Metab. (IF 19.865) Pub Date : 2022-07-11 Shivang Parikh, Roma Parikh, Keren Michael, Lior Bikovski, Georgina Barnabas, Mariya Mardamshina, Rina Hemi, Paulee Manich, Nir Goldstein, Hagar Malcov-Brog, Tom Ben-Dov, Ohad Glaich, Daphna Liber, Yael Bornstein, Koral Goltseker, Roy Ben-Bezalel, Mor Pavlovsky, Tamar Golan, Liron Spitzer, Hagit Matz, Pinchas Gonen, Ruth Percik, Lior Leibou, Tomer Perluk, Gil Ast, Jacob Frand, Ronen Brenner, Tamar
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Metabolic Messengers: endocannabinoids Nat. Metab. (IF 19.865) Pub Date : 2022-07-11 Arnau Busquets-García, Juan P. Bolaños, Giovanni Marsicano
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Keeping ILCs in shape: PD-1 as a metabolic checkpoint Nat. Metab. (IF 19.865) Pub Date : 2022-07-04 Laura Surace, Christoph Wilhelm
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Targeted erasure of DNA methylation by TET3 drives adipogenic reprogramming and differentiation Nat. Metab. (IF 19.865) Pub Date : 2022-07-04 Jeu Park, Do Hoon Lee, Seokjin Ham, Jiyoung Oh, Jung-Ran Noh, Yun Kyung Lee, Yoon Jeong Park, Gung Lee, Sang Mun Han, Ji Seul Han, Ye Young Kim, Yong Geun Jeon, Han Nahmgoong, Kyung Cheul Shin, Sung Min Kim, Sung Hee Choi, Chul-Ho Lee, Jiyoung Park, Tae Young Roh, Sun Kim, Jae Bum Kim
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PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation Nat. Metab. (IF 19.865) Pub Date : 2022-07-04 Di Wu, Luni Hu, Mengwei Han, Yichen Deng, Yime Zhang, Guanqun Ren, Xingyu Zhao, Zongxian Li, Peng Li, Yinlian Zhang, Shanwen Chen, Jun Li, Yanyan Shi, Jianxin Xue, Pengyuan Wang, Chao Zhong
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Brown fat resolves hepatic inflammation in obesity Nat. Metab. (IF 19.865) Pub Date : 2022-06-27 Francesc Villarroya, Aleix Gavaldà-Navarro
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AgRP neurons control feeding behaviour at cortical synapses via peripherally derived lysophospholipids Nat. Metab. (IF 19.865) Pub Date : 2022-06-27 Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt
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Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo Nat. Metab. (IF 19.865) Pub Date : 2022-06-27 Michael P. Murphy, Hülya Bayir, Vsevolod Belousov, Christopher J. Chang, Kelvin J. A. Davies, Michael J. Davies, Tobias P. Dick, Toren Finkel, Henry J. Forman, Yvonne Janssen-Heininger, David Gems, Valerian E. Kagan, Balaraman Kalyanaraman, Nils-Göran Larsson, Ginger L. Milne, Thomas Nyström, Henrik E. Poulsen, Rafael Radi, Holly Van Remmen, Paul T. Schumacker, Paul J. Thornalley, Shinya Toyokuni,
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Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix Nat. Metab. (IF 19.865) Pub Date : 2022-06-27 Emily J. Kay, Karla Paterson, Carla Riero-Domingo, David Sumpton, J. Henry M. Däbritz, Saverio Tardito, Claudia Boldrini, Juan R. Hernandez-Fernaud, Dimitris Athineos, Sandeep Dhayade, Ekaterina Stepanova, Enio Gjerga, Lisa J. Neilson, Sergio Lilla, Ann Hedley, Grigorios Koulouras, Grace McGregor, Craig Jamieson, Radia Marie Johnson, Morag Park, Kristina Kirschner, Crispin Miller, Jurre J. Kamphorst
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Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation Nat. Metab. (IF 19.865) Pub Date : 2022-06-27 Satoru Sugimoto, Hebe Agustina Mena, Brian E. Sansbury, Shio Kobayashi, Tadataka Tsuji, Chih-Hao Wang, Xuanzhi Yin, Tian Lian Huang, Joji Kusuyama, Sean D. Kodani, Justin Darcy, Gerson Profeta, Nayara Pereira, Rudolph E. Tanzi, Can Zhang, Thomas Serwold, Efi Kokkotou, Laurie J. Goodyear, Aaron M. Cypess, Luiz Osório Leiria, Matthew Spite, Yu-Hua Tseng
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Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome Nat. Metab. (IF 19.865) Pub Date : 2022-06-27 Shuijie Li, Wenyu Li, Juan Yuan, Petra Bullova, Jieyu Wu, Xuepei Zhang, Yong Liu, Monika Plescher, Javier Rodriguez, Oscar C. Bedoya-Reina, Paulo R. Jannig, Paula Valente-Silva, Meng Yu, Marie Arsenian Henriksson, Roman A. Zubarev, Anna Smed-Sörensen, Carolyn K. Suzuki, Jorge L. Ruas, Johan Holmberg, Catharina Larsson, C. Christofer Juhlin, Alex von Kriegsheim, Yihai Cao, Susanne Schlisio
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NAD+ regeneration drives cancer cell proliferation Nat. Metab. (IF 19.865) Pub Date : 2022-06-23 Xu Han, M. Celeste Simon
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The transcription factor RFX5 coordinates antigen-presenting function and resistance to nutrient stress in synovial macrophages Nat. Metab. (IF 19.865) Pub Date : 2022-06-23 Zhaolan Hu, Tuantuan V. Zhao, Tao Huang, Shozo Ohtsuki, Ke Jin, Isabel N. Goronzy, Bowen Wu, Matthew P. Abdel, Jacob W. Bettencourt, Gerald J. Berry, Jörg J. Goronzy, Cornelia M. Weyand
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Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited Nat. Metab. (IF 19.865) Pub Date : 2022-06-23 Zhaoqi Li, Brian W. Ji, Purushottam D. Dixit, Konstantine Tchourine, Evan C. Lien, Aaron M. Hosios, Keene L. Abbott, Justine C. Rutter, Anna M. Westermark, Elizabeth F. Gorodetsky, Lucas B. Sullivan, Matthew G. Vander Heiden, Dennis Vitkup
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YAP/TAZ–TEAD link angiogenesis to nutrients Nat. Metab. (IF 19.865) Pub Date : 2022-06-20 Roxana E. Oberkersch, Massimo M. Santoro
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A YAP/TAZ-TEAD signalling module links endothelial nutrient acquisition to angiogenic growth Nat. Metab. (IF 19.865) Pub Date : 2022-06-20 Yu Ting Ong, Jorge Andrade, Max Armbruster, Chenyue Shi, Marco Castro, Ana S. H. Costa, Toshiya Sugino, Guy Eelen, Barbara Zimmermann, Kerstin Wilhelm, Joseph Lim, Shuichi Watanabe, Stefan Guenther, Andre Schneider, Francesca Zanconato, Manuel Kaulich, Duojia Pan, Thomas Braun, Holger Gerhardt, Alejo Efeyan, Peter Carmeliet, Stefano Piccolo, Ana Rita Grosso, Michael Potente
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Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia Nat. Metab. (IF 19.865) Pub Date : 2022-06-20 Javier Garcia-Bermudez, Michael A. Badgley, Sheela Prasad, Lou Baudrier, Yuyang Liu, Konnor La, Mariluz Soula, Robert T. Williams, Norihiro Yamaguchi, Rosa F. Hwang, Laura J. Taylor, Elisa de Stanchina, Bety Rostandy, Hanan Alwaseem, Henrik Molina, Dafna Bar-Sagi, Kıvanç Birsoy
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Metabolic Messengers: fibroblast growth factor 1 Nat. Metab. (IF 19.865) Pub Date : 2022-06-09 Emanuel Gasser, Gencer Sancar, Michael Downes, Ronald M. Evans
While fibroblast growth factor (FGF) 1 is expressed in multiple tissues, only adipose-derived and brain FGF1 have been implicated in the regulation of metabolism. Adipose FGF1 production is upregulated in response to dietary stress and is essential for adipose tissue plasticity in these conditions. Similarly, in the brain, FGF1 secretion into the ventricular space and the adjacent parenchyma is increased
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The itaconate family of immunomodulators grows Nat. Metab. (IF 19.865) Pub Date : 2022-06-02 Anne F. McGettrick, Luke A. J. O’Neill
Itaconate is an immunomodulatory Krebs cycle-derived metabolite. Description of two isomers of itaconate, mesaconate and citraconate, which have overlapping and distinct properties when compared with itaconate in macrophages, expands the knowledge of this intriguing family of immunomodulatory metabolites.
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Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages Nat. Metab. (IF 19.865) Pub Date : 2022-06-02 Wei He, Antonia Henne, Mario Lauterbach, Eike Geißmar, Fabian Nikolka, Celia Kho, Alexander Heinz, Catherine Dostert, Melanie Grusdat, Thekla Cordes, Janika Härm, Oliver Goldmann, Anouk Ewen, Charlène Verschueren, Julia Blay-Cadanet, Robert Geffers, Hendrikus Garritsen, Manfred Kneiling, Christian K. Holm, Christian M. Metallo, Eva Medina, Zeinab Abdullah, Eicke Latz, Dirk Brenner, Karsten Hiller
Since its discovery in inflammatory macrophages, itaconate has attracted much attention due to its antimicrobial and immunomodulatory activity1,2,3. However, instead of investigating itaconate itself, most studies used derivatized forms of itaconate and thus the role of non-derivatized itaconate needs to be scrutinized. Mesaconate, a metabolite structurally very close to itaconate, has never been implicated
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Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism Nat. Metab. (IF 19.865) Pub Date : 2022-06-02 F. Chen, W. A. M. Elgaher, M. Winterhoff, K. Büssow, F. H. Waqas, E. Graner, Y. Pires-Afonso, L. Casares Perez, L. de la Vega, N. Sahini, L. Czichon, W. Zobl, T. Zillinger, M. Shehata, S. Pleschka, H. Bähre, C. Falk, A. Michelucci, S. Schuchardt, W. Blankenfeldt, A. K. H. Hirsch, F. Pessler
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Sex differences in the intergenerational inheritance of metabolic traits Nat. Metab. (IF 19.865) Pub Date : 2022-05-30 Ionel Sandovici, Denise S. Fernandez-Twinn, Antonia Hufnagel, Miguel Constância, Susan E. Ozanne
Strong evidence suggests that early-life exposures to suboptimal environmental factors, including those in utero, influence our long-term metabolic health. This has been termed developmental programming. Mounting evidence suggests that the growth and metabolism of male and female fetuses differ. Therefore, sexual dimorphism in response to pre-conception or early-life exposures could contribute to known
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PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis during ageing Nat. Metab. (IF 19.865) Pub Date : 2022-05-26 Egle Danileviciute, Ni Zeng, Christophe M. Capelle, Nicole Paczia, Mark A. Gillespie, Henry Kurniawan, Mohaned Benzarti, Myriam P. Merz, Djalil Coowar, Sabrina Fritah, Daniela Maria Vogt Weisenhorn, Gemma Gomez Giro, Melanie Grusdat, Alexandre Baron, Coralie Guerin, Davide G. Franchina, Cathy Léonard, Olivia Domingues, Sylvie Delhalle, Wolfgang Wurst, Jonathan D. Turner, Jens Christian Schwamborn,
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson’s disease gene) is a pacemaker regulating PDH activity in CD4+ regulatory T cells (Treg cells). DJ-1 binds to PDHE1-β (PDHB), inhibiting phosphorylation of PDHE1-α (PDHA), thus promoting PDH activity and oxidative phosphorylation
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TKT deficiency puts Tregs to rest Nat. Metab. (IF 19.865) Pub Date : 2022-05-23 Margarita Dominguez-Villar
Activation of resting regulatory T cells (Tregs) upon antigen encounter is essential for proper Treg function. However, the metabolic pathways that mediate this transition are unknown. Liu et al. have identified the non-oxidative pentose phosphate pathway as a central regulator of Treg activation and function.
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Non-oxidative pentose phosphate pathway controls regulatory T cell function by integrating metabolism and epigenetics Nat. Metab. (IF 19.865) Pub Date : 2022-05-23 Qi Liu, Fangming Zhu, Xinnan Liu, Ying Lu, Ke Yao, Na Tian, Lingfeng Tong, David A. Figge, Xiuwen Wang, Yichao Han, Yakui Li, Yemin Zhu, Lei Hu, Yingning Ji, Nannan Xu, Dan Li, Xiaochuan Gu, Rui Liang, Guifang Gan, Lifang Wu, Ping Zhang, Tianle Xu, Hui Hu, Zeping Hu, Huji Xu, Dan Ye, Hui Yang, Bin Li, Xuemei Tong
Regulatory T (Treg) cells are critical for maintaining immune homeostasis and preventing autoimmunity. Here, we show that the non-oxidative pentose phosphate pathway (PPP) regulates Treg function to prevent autoimmunity. Deletion of transketolase (TKT), an indispensable enzyme of non-oxidative PPP, in Treg cells causes a fatal autoimmune disease in mice, with impaired Treg suppressive capability despite
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Raising the bar for sex and gender reporting in research Nat. Metab. (IF 19.865) Pub Date : 2022-05-18
Nature Metabolism and the Nature journals are raising the standards for reporting on sex and gender in research. Starting this June, authors will be prompted to provide details on how sex and gender were considered in study design.
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β-Klotho promotes glycolysis and glucose-stimulated insulin secretion via GP130 Nat. Metab. (IF 19.865) Pub Date : 2022-05-12 Leiluo Geng, Boya Liao, Leigang Jin, Jiasui Yu, Xiaoyu Zhao, Yuntao Zhao, Ling Zhong, Baile Wang, Jiufeng Li, Jie Liu, Jin-Kui Yang, Wei Jia, Qizhou Lian, Aimin Xu
Impaired glucose-stimulated insulin secretion (GSIS) is a hallmark of type-2 diabetes. However, cellular signaling machineries that control GSIS remain incompletely understood. Here, we report that β-klotho (KLB), a single-pass transmembrane protein known as a co-receptor for fibroblast growth factor 21 (FGF21), fine tunes GSIS via modulation of glycolysis in pancreatic β-cells independent of the actions
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A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 Nat. Metab. (IF 19.865) Pub Date : 2022-05-09 Liangqin Tong, Xiaoping Xiao, Min Li, Shisong Fang, Enhao Ma, Xi Yu, Yibin Zhu, Chunli Wu, Deyu Tian, Fan Yang, Jing Sun, Jing Qu, Nianzhen Zheng, Shumin Liao, Wanbo Tai, Shengyong Feng, Liming Zhang, Yuhan Li, Lin Wang, Xuelian Han, Shihui Sun, Long Yang, Hui Zhong, Jincun Zhao, Wenjun Liu, Xiaohui Liu, Penghua Wang, Liang Li, Guangyu Zhao, Renli Zhang, Gong Cheng
The severity and mortality of COVID-19 are associated with pre-existing medical comorbidities such as diabetes mellitus. However, the underlying causes for increased susceptibility to viral infection in patients with diabetes is not fully understood. Here we identify several small-molecule metabolites from human blood with effective antiviral activity against SARS-CoV-2, one of which, 1,5-anhydro-d-glucitol
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An anti-SARS-CoV-2 metabolite is reduced in diabetes Nat. Metab. (IF 19.865) Pub Date : 2022-05-09 Júlia Vergara-Alert, Nuria Izquierdo-Useros
A glucose-like metabolite, which is reduced in the serum of diabetic patients, inhibits the entry of SARS-CoV-2 into key cellular targets. The work led by Cheng and colleagues provides a molecular explanation for the increased risk of severe COVID-19 in patients with diabetes.
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Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumour growth Nat. Metab. (IF 19.865) Pub Date : 2022-05-09 Chunming Cheng, Feng Geng, Zoe Li, Yaogang Zhong, Huabao Wang, Xiang Cheng, Yue Zhao, Xiaokui Mo, Craig Horbinski, Wenrui Duan, Arnab Chakravarti, Xiaolin Cheng, Deliang Guo
Tumorigenesis is associated with elevated glucose and glutamine consumption, but how cancer cells can sense their levels to activate lipid synthesis is unknown. Here, we reveal that ammonia, released from glutamine, promotes lipogenesis via activation of sterol regulatory element-binding proteins (SREBPs), endoplasmic reticulum-bound transcription factors that play a central role in lipid metabolism
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Astroglial clean-up of satiety synapses Nat. Metab. (IF 19.865) Pub Date : 2022-05-02 Tim Gruber, Cristina García-Cáceres
Until now, the BDNF–TrkB signalling pathway was thought to be exclusively regulated by neurons. Ameroso et al. show that astrocytic TrkB.T1 is a critical substrate of BDNF in the regulation of energy balance and that its defective signalling in hypothalamic circuits leads to obesity.
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Astrocytic BDNF signaling within the ventromedial hypothalamus regulates energy homeostasis Nat. Metab. (IF 19.865) Pub Date : 2022-05-02 Dominique Ameroso, Alice Meng, Stella Chen, Jennifer Felsted, Chris G. Dulla, Maribel Rios
Brain-derived neurotrophic factor (BDNF) is essential for maintaining energy and glucose balance within the central nervous system. Because the study of its metabolic actions has been limited to effects in neuronal cells, its role in other cell types within the brain remains poorly understood. Here we show that astrocytic BDNF signaling within the ventromedial hypothalamus (VMH) modulates neuronal
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Peeling back the layers of the glucose clamp Nat. Metab. (IF 19.865) Pub Date : 2022-04-27 Julio E. Ayala, Louise Lantier, Owen P. McGuinness, David H. Wasserman
Glucose clamps are challenging to conduct in mice and experimental approaches vary between laboratories, which complicates data interpretation and comparison of results. Here, we highlight key methodological differences and propose reporting standards for glucose clamps.
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Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance Nat. Metab. (IF 19.865) Pub Date : 2022-04-25 V. Pellegrinelli, S. Rodriguez-Cuenca, C. Rouault, E. Figueroa-Juarez, H. Schilbert, S. Virtue, J. M. Moreno-Navarrete, G. Bidault, M. C. Vázquez-Borrego, A. R. Dias, B. Pucker, M. Dale, M. Campbell, S. Carobbio, Y. H. Lin, M. Vacca, J. Aron-Wisnewsky, S. Mora, M. M. Masiero, A. Emmanouilidou, S. Mukhopadhyay, G. Dougan, M. den Hoed, R. J. F. Loos, J. M. Fernández-Real, D. Chiarugi, K. Clément, A.
Resulting from impaired collagen turnover, fibrosis is a hallmark of adipose tissue (AT) dysfunction and obesity-associated insulin resistance (IR). Prolidase, also known as peptidase D (PEPD), plays a vital role in collagen turnover by degrading proline-containing dipeptides but its specific functional relevance in AT is unknown. Here we show that in human and mouse obesity, PEPD expression and activity
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The gut microbial metabolite formate exacerbates colorectal cancer progression Nat. Metab. (IF 19.865) Pub Date : 2022-04-18 Dominik Ternes, Mina Tsenkova, Vitaly Igorevich Pozdeev, Marianne Meyers, Eric Koncina, Sura Atatri, Martine Schmitz, Jessica Karta, Maryse Schmoetten, Almut Heinken, Fabien Rodriguez, Catherine Delbrouck, Anthoula Gaigneaux, Aurelien Ginolhac, Tam Thuy Dan Nguyen, Lea Grandmougin, Audrey Frachet-Bour, Camille Martin-Gallausiaux, Maria Pacheco, Lorie Neuberger-Castillo, Paulo Miranda, Nikolaus Zuegel
The gut microbiome is a key player in the immunomodulatory and protumorigenic microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can induce tumour growth. However, the crosstalk between the gut microbiome and the host in relation to tumour cell metabolism remains largely unexplored. Here we show that formate, a metabolite produced by the CRC-associated bacterium Fusobacterium
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Science in times of conflict Nat. Metab. (IF 19.865) Pub Date : 2022-04-12
Global scientific collaboration should endure despite the humanitarian crisis in Europe.
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Career pathways, part 8 Nat. Metab. (IF 19.865) Pub Date : 2022-04-06 Maria Ermolaeva, Liron Boyman
Maria Ermolaeva and Liron Boyman share their scientific journeys in this instalment of Career pathways and highlight the value of mentors and collaborators, and the importance of following your research interests.
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Inconsistent nomenclature of microbiota-associated metabolites hampers progress of the field. Nat. Metab. (IF 19.865) Pub Date : 2022-04-01 Olli Kärkkäinen,Ville Koistinen,Kati Hanhineva
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Dopamine drives food craving during pregnancy Nat. Metab. (IF 19.865) Pub Date : 2022-04-04 Serge Luquet, Giuseppe Gangarossa
Although food-craving episodes during pregnancy are common in humans, the neural, cellular and molecular mechanisms that underlie these eating bouts remain unknown. New work points to dopamine receptor D2-expressing neurons of the reward system as critical mediators of compulsive feeding during pregnancy.
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Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits Nat. Metab. (IF 19.865) Pub Date : 2022-04-04 Roberta Haddad-Tóvolli, Sara Ramírez, Emma Muñoz-Moreno, Maria Milà-Guasch, Lluis Miquel-Rio, Macarena Pozo, Iñigo Chivite, Jordi Altirriba, Arnaud Obri, Alicia G. Gómez-Valadés, Miriam Toledo, Elena Eyre, Analia Bortolozzi, Emmanuel Valjent, Guadalupe Soria, Marc Claret
Preparation for motherhood requires a myriad of physiological and behavioural adjustments throughout gestation to provide an adequate environment for proper embryonic development1. Cravings for highly palatable foods are highly prevalent during pregnancy2 and contribute to the maintenance and development of gestational overweight or obesity3. However, the neurobiology underlying the distinct ingestive
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Methylmalonic acid: an age-related metabolite that drives tumour aggressiveness Nat. Metab. (IF 19.865) Pub Date : 2022-03-31 Emily J. Kay, Sara Zanivan
Oncometabolites are pro-tumourigenic metabolites that can determine tumour aggressiveness. This study found that methylmalonic acid is upregulated in breast lung metastasis and metastatic cancer cells. Methylmalonic acid alters the gene expression profile to induce a pro-metastatic phenotype in breast and lung cancer cells.
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Dying cell-derived SAM switches off inflammation Nat. Metab. (IF 19.865) Pub Date : 2022-03-31 Roel P. H. De Maeyer, Derek W. Gilroy
The clearance of dying cells by macrophages releases mediators that switch off inflammation. Ampomah et al. reveal how an amino acid derived from apoptotic cargo changes the methylation epigenome of macrophages to take the brakes off an ERK-dependent pathway that terminates inflammatory responses.
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Macrophages use apoptotic cell-derived methionine and DNMT3A during efferocytosis to promote tissue resolution Nat. Metab. (IF 19.865) Pub Date : 2022-03-31 Patrick B. Ampomah, Bishuang Cai, Santosh R. Sukka, Brennan D. Gerlach, Arif Yurdagul, Xiaobo Wang, George Kuriakose, Lancia N. F. Darville, Yan Sun, Simone Sidoli, John M. Koomen, Alan R. Tall, Ira Tabas
Efferocytosis, the clearance of apoptotic cells (ACs) by macrophages, is critical for tissue resolution, with defects driving many diseases. Mechanisms of efferocytosis-mediated resolution are incompletely understood. Here, we show that AC-derived methionine regulates resolution through epigenetic repression of the extracellular signal-regulated kinase 1/2 (ERK1/2) phosphatase Dusp4. We focus on two