-
Metformin induces a Lac-Phe gut–brain signalling axis Nat. Metab. (IF 20.8) Pub Date : 2024-03-18 Tara TeSlaa
-
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans Nat. Metab. (IF 20.8) Pub Date : 2024-03-18 Barry Scott, Emily A. Day, Katie L. O’Brien, John Scanlan, Grace Cromwell, Aine Ni Scannail, Marie E. McDonnell, David K. Finlay, Lydia Lynch
-
Lac-Phe mediates the effects of metformin on food intake and body weight Nat. Metab. (IF 20.8) Pub Date : 2024-03-18 Shuke Xiao, Veronica L. Li, Xuchao Lyu, Xudong Chen, Wei Wei, Fahim Abbasi, Joshua W. Knowles, Alan Sheng-Hwa Tung, Shuliang Deng, Gaurav Tiwari, Xu Shi, Shuning Zheng, Laurie Farrell, Zsu-Zsu Chen, Kent D. Taylor, Xiuqing Guo, Mark O. Goodarzi, Alexis C. Wood, Yii-Der Ida Chen, Leslie A. Lange, Stephen S. Rich, Jerome I. Rotter, Clary B. Clish, Usman A. Tahir, Robert E. Gerszten, Mark D. Benson, Jonathan
-
Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake Nat. Metab. (IF 20.8) Pub Date : 2024-03-11 Yawen Zhao, Yang Liu, Tian Tao, Jinshan Zhang, Wenying Guo, Handan Deng, Mengxue Han, Haocong Mo, Xiaohan Tong, Song Lin, Jie Yang, Hening Zhai, Qimeng Wang, Zhengfang Hu, Weizhen Zhang, Hui Chen, Geyang Xu
-
The pressure not to eat Nat. Metab. (IF 20.8) Pub Date : 2024-03-11 Choi Sang Daniel Lam, M. Maya Kaelberer
-
Futile lipid cycling: from biochemistry to physiology Nat. Metab. (IF 20.8) Pub Date : 2024-03-08 Anand Kumar Sharma, Radhika Khandelwal, Christian Wolfrum
-
Regulation of urea cycle by reversible high-stoichiometry lysine succinylation Nat. Metab. (IF 20.8) Pub Date : 2024-03-06 Ran Zhang, Jingqi Fang, Xueshu Xie, Chris Carrico, Jesse G. Meyer, Lei Wei, Joanna Bons, Jacob Rose, Rebeccah Riley, Ryan Kwok, Prasanna Vadhana Ashok Kumaar, Yini Zhang, Wenjuan He, Yuya Nishida, Xiaojing Liu, Jason W. Locasale, Birgit Schilling, Eric Verdin
-
Glycogen from spinal astrocytes dials up the pain Nat. Metab. (IF 20.8) Pub Date : 2024-03-05 Carlos Manlio Díaz-García
-
Neuron–astrocyte metabolic coupling facilitates spinal plasticity and maintenance of inflammatory pain Nat. Metab. (IF 20.8) Pub Date : 2024-03-05 Sebastián Marty-Lombardi, Shiying Lu, Wojciech Ambroziak, Katrin Schrenk-Siemens, Jialin Wang, Anna A. DePaoli-Roach, Anna M. Hagenston, Hagen Wende, Anke Tappe-Theodor, Manuela Simonetti, Hilmar Bading, Jürgen G. Okun, Rohini Kuner, Thomas Fleming, Jan Siemens
-
Determinants of obesity in Latin America Nat. Metab. (IF 20.8) Pub Date : 2024-03-04 Sandra Roberta G. Ferreira, Yazmín Macotela, Licio A. Velloso, Marcelo A. Mori
-
Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans Nat. Metab. (IF 20.8) Pub Date : 2024-02-28 Chen Lesnik, Rachel Kaletsky, Jasmine M. Ashraf, Salman Sohrabi, Vanessa Cota, Titas Sengupta, William Keyes, Shijing Luo, Coleen T. Murphy
-
The weight-loss-independent benefits of fasting Nat. Metab. (IF 20.8) Pub Date : 2024-03-01 Benjamin D. Horne
-
Systemic proteome adaptions to 7-day complete caloric restriction in humans Nat. Metab. (IF 20.8) Pub Date : 2024-03-01 Maik Pietzner, Burulça Uluvar, Kristoffer J. Kolnes, Per B. Jeppesen, S. Victoria Frivold, Øyvind Skattebo, Egil I. Johansen, Bjørn S. Skålhegg, Jørgen F. P. Wojtaszewski, Anders J. Kolnes, Giles S. H. Yeo, Stephen O’Rahilly, Jørgen Jensen, Claudia Langenberg
-
Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression Nat. Metab. (IF 20.8) Pub Date : 2024-02-27 Leah A. Gates, Bernardo Sgarbi Reis, Peder J. Lund, Matthew R. Paul, Marylene Leboeuf, Annaelle M. Djomo, Zara Nadeem, Mariana Lopes, Francisca N. Vitorino, Gokhan Unlu, Thomas S. Carroll, Kivanç Birsoy, Benjamin A. Garcia, Daniel Mucida, C. David Allis
-
Slowing reproductive ageing by preserving BCAT-1 Nat. Metab. (IF 20.8) Pub Date : 2024-02-28 Leah E. Jamerson, Patrick C. Bradshaw
-
Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity Nat. Metab. (IF 20.8) Pub Date : 2024-02-28 Gerald Grandl, Gustav Collden, Jin Feng, Sreya Bhattacharya, Felix Klingelhuber, Leopold Schomann, Sara Bilekova, Ansarullah, Weiwei Xu, Fataneh Fathi Far, Monica Tost, Tim Gruber, Aimée Bastidas-Ponce, Qian Zhang, Aaron Novikoff, Arkadiusz Liskiewicz, Daniela Liskiewicz, Cristina Garcia-Caceres, Annette Feuchtinger, Matthias H. Tschöp, Natalie Krahmer, Heiko Lickert, Timo D. Müller
-
Histone butyrylation is a dietary link to epigenetics Nat. Metab. (IF 20.8) Pub Date : 2024-02-27 Yudong Sun, Jason W. Locasale
-
PMF-seq: a highly scalable screening strategy for linking genetics to mitochondrial bioenergetics Nat. Metab. (IF 20.8) Pub Date : 2024-02-27 Tsz-Leung To, Jason G. McCoy, Naomi K. Ostriker, Lev S. Sandler, Carmen A. Mannella, Vamsi K. Mootha
-
Resisting weight gain with prebiotic fibre Nat. Metab. (IF 20.8) Pub Date : 2024-02-26 Matthew M. Carter, Sean P. Spencer
-
Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice Nat. Metab. (IF 20.8) Pub Date : 2024-02-26
-
Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression Nat. Metab. (IF 20.8) Pub Date : 2024-02-26 Tianshu Shi, Siyu Shen, Yong Shi, Qianjin Wang, Guanqun Zhang, Jiaquan Lin, Jiang Chen, Feng Bai, Lei Zhang, Yangyufan Wang, Wang Gong, Xiaoyan Shao, Guiquan Chen, Wenjin Yan, Xiang Chen, Yuze Ma, Liming Zheng, Jianghui Qin, Ke Lu, Na Liu, Yun Xu, Yun Stone Shi, Qing Jiang, Baosheng Guo
-
Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota Nat. Metab. (IF 20.8) Pub Date : 2024-02-26 Huating Li, Lei Zhang, Jun Li, Qian Wu, Lingling Qian, Junsheng He, Yueqiong Ni, Petia Kovatcheva-Datchary, Rui Yuan, Shuangbo Liu, Li Shen, Mingliang Zhang, Bin Sheng, Ping Li, Kang Kang, Liang Wu, Qichen Fang, Xiaoxue Long, Xiaolin Wang, Yanli Li, Yaorui Ye, Jianping Ye, Yuqian Bao, Yueliang Zhao, Guowang Xu, Xinyu Liu, Gianni Panagiotou, Aimin Xu, Weiping Jia
-
From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research Nat. Metab. (IF 20.8) Pub Date : 2024-02-21 Cynthia L. Hsu, Rohit Loomba
-
Enteric and systemic postprandial lactate shuttle phases and dietary carbohydrate carbon flow in humans Nat. Metab. (IF 20.8) Pub Date : 2024-02-22 Robert G. Leija, Casey C. Curl, Jose A. Arevalo, Adam D. Osmond, Justin J. Duong, Melvin J. Huie, Umesh Masharani, George A. Brooks
-
Metabolic engineering for optimized CAR-T cell therapy Nat. Metab. (IF 20.8) Pub Date : 2024-02-22 Sarah J. McPhedran, Gillian A. Carleton, Julian J. Lum
-
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism Nat. Metab. (IF 20.8) Pub Date : 2024-02-20 Alain J. De Solis, Almudena Del Río-Martín, Jan Radermacher, Weiyi Chen, Lukas Steuernagel, Corinna A. Bauder, Fynn R. Eggersmann, Donald A. Morgan, Anna-Lena Cremer, Michael Sué, Maximilian Germer, Christian Kukat, Stefan Vollmar, Heiko Backes, Kamal Rahmouni, Peter Kloppenburg, Jens C. Brüning
-
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk Nat. Metab. (IF 20.8) Pub Date : 2024-02-19 Xiangyu Zhang, Divya Kapoor, Se-Jin Jeong, Alan Fappi, Jeremiah Stitham, Vasavi Shabrish, Ismail Sergin, Eman Yousif, Astrid Rodriguez-Velez, Yu-Sheng Yeh, Arick Park, Arif Yurdagul, Oren Rom, Slava Epelman, Joel D. Schilling, Marco Sardiello, Abhinav Diwan, Jaehyung Cho, Nathan O. Stitziel, Ali Javaheri, Irfan J. Lodhi, Bettina Mittendorfer, Babak Razani
-
MCT1 helps brown fat suck up succinate Nat. Metab. (IF 20.8) Pub Date : 2024-02-20 Jens Lund, Marie Sophie Isidor, Zachary Gerhart-Hines
-
Simultaneous targeting of POMC and AgRP neurons Nat. Metab. (IF 20.8) Pub Date : 2024-02-20 Liangyou Rui
-
Monocarboxylate transporters facilitate succinate uptake into brown adipocytes Nat. Metab. (IF 20.8) Pub Date : 2024-02-20 Anita Reddy, Sally Winther, Nhien Tran, Haopeng Xiao, Josefine Jakob, Ryan Garrity, Arianne Smith, Martha Ordonez, Dina Laznik-Bogoslavski, Jeffrey D. Rothstein, Evanna L. Mills, Edward T. Chouchani
-
Accumulation of G3P and pEtN drives cellular senescence via altered lipid metabolism Nat. Metab. (IF 20.8) Pub Date : 2024-02-19
-
A leucine–macrophage mTORC1 connection drives increased risk of atherosclerosis with high-protein diets Nat. Metab. (IF 20.8) Pub Date : 2024-02-19 Adam J. Rose, Patricia M. Rusu
-
A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism Nat. Metab. (IF 20.8) Pub Date : 2024-02-19 Khaled Tighanimine, José Américo Nabuco Leva Ferreira Freitas, Ivan Nemazanyy, Alexia Bankolé, Delphine Benarroch-Popivker, Susanne Brodesser, Gregory Doré, Lucas Robinson, Paule Benit, Sophia Ladraa, Yara Bou Saada, Bertrand Friguet, Philippe Bertolino, David Bernard, Guillaume Canaud, Pierre Rustin, Eric Gilson, Oliver Bischof, Stefano Fumagalli, Mario Pende
-
Best practices in collecting and reporting continuous glucose monitoring data in research settings Nat. Metab. (IF 20.8) Pub Date : 2024-02-15 Margaretha M. Visser, Pieter Gillard
Continuous glucose monitoring (CGM) is increasingly being used to collect and evaluate data on glycaemic control for research purposes. However, the use of CGM in research settings requires proper understanding and handling of these devices for correct data collection and interpretation.
-
Selenium abandons selenoproteins to inhibit ferroptosis rapidly Nat. Metab. (IF 20.8) Pub Date : 2024-02-13 Ian G. Chambers, Rajiv R. Ratan
-
Selenium reduction of ubiquinone via SQOR suppresses ferroptosis Nat. Metab. (IF 20.8) Pub Date : 2024-02-13 Namgyu Lee, Sung Jin Park, Mike Lange, Tenzin Tseyang, Mihir B. Doshi, Tae Yong Kim, Yoseb Song, Dong In Kim, Paul L. Greer, James A. Olzmann, Jessica B. Spinelli, Dohoon Kim
-
Hypermetabolism and energetic constraints in mitochondrial disorders Nat. Metab. (IF 20.8) Pub Date : 2024-02-09 Alexander J. Sercel, Gabriel Sturm, Dympna Gallagher, Marie-Pierre St-Onge, Christopher P. Kempes, Herman Pontzer, Michio Hirano, Martin Picard
-
Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis Nat. Metab. (IF 20.8) Pub Date : 2024-02-09 Krithika Ramachandran, Christopher R. Futtner, Meredith A. Sommars, Mattia Quattrocelli, Yasuhiro Omura, Ellen Fruzyna, Janice C. Wang, Nathan J. Waldeck, Madhavi D. Senagolage, Carmen G. Telles, Alexis R. Demonbreun, Erin Prendergast, Nicola Lai, Daniel Arango, Ilya R. Bederman, Elizabeth M. McNally, Grant D. Barish
-
A GIPR antagonist conjugated to GLP-1 analogues promotes weight loss with improved metabolic parameters in preclinical and phase 1 settings Nat. Metab. (IF 20.8) Pub Date : 2024-02-05 Murielle M. Véniant, Shu-Chen Lu, Larissa Atangan, Renee Komorowski, Shanaka Stanislaus, Yuan Cheng, Bin Wu, James R. Falsey, Todd Hager, Veena A. Thomas, Malhar Ambhaikar, Lucie Sharpsten, Yineng Zhu, Vamsi Kurra, Rohini Jeswani, Rajneet K. Oberoi, Jane R. Parnes, Narimon Honarpour, Joel Neutel, Jennifer L. Strande
-
A RalA between high-fat diet and mitochondrial shape Nat. Metab. (IF 20.8) Pub Date : 2024-01-29 Ludovica Zambello, Luca Scorrano
-
Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation Nat. Metab. (IF 20.8) Pub Date : 2024-01-29 Wenmin Xia, Preethi Veeragandham, Yu Cao, Yayun Xu, Torrey E. Rhyne, Jiaxin Qian, Chao-Wei Hung, Peng Zhao, Ying Jones, Hui Gao, Christopher Liddle, Ruth T. Yu, Michael Downes, Ronald M. Evans, Mikael Rydén, Martin Wabitsch, Zichen Wang, Hiroyuki Hakozaki, Johannes Schöneberg, Shannon M. Reilly, Jianfeng Huang, Alan R. Saltiel
-
Five years on Nat. Metab. (IF 20.8) Pub Date : 2024-01-25
This month, Nature Metabolism turns five. For a young journal such as ours, this anniversary represents a milestone worth celebrating, and a welcome opportunity to look back.
-
Functionally heterogeneous β cells regulate biphasic insulin secretion Nat. Metab. (IF 20.8) Pub Date : 2024-01-26
-
Big data and personalized nutrition: the key evidence gaps Nat. Metab. (IF 20.8) Pub Date : 2024-01-26 Nicola Guess
The field of personalized nutrition hypothesizes that ‘big data’ — biological, behavioural, social and environmental — can be leveraged to make more precise and effective dietary recommendations to individuals for improving health outcomes, compared to generic dietary advice. This article describes the research questions that need to be answered to understand whether personalized nutrition brings additional
-
Readily releasable β cells with tight Ca2+–exocytosis coupling dictate biphasic glucose-stimulated insulin secretion Nat. Metab. (IF 20.8) Pub Date : 2024-01-26 Xiaohong Peng, Huixia Ren, Lu Yang, Shiyan Tong, Renjie Zhou, Haochen Long, Yunxiang Wu, Lifen Wang, Yi Wu, Yongdeng Zhang, Jiayu Shen, Junwei Zhang, Guohua Qiu, Jianyong Wang, Chengsheng Han, Yulin Zhang, Mengxuan Zhou, Yiwen Zhao, Tao Xu, Chao Tang, Zhixing Chen, Huisheng Liu, Liangyi Chen
-
Genetic architecture and biology of youth-onset type 2 diabetes Nat. Metab. (IF 20.8) Pub Date : 2024-01-26 Soo Heon Kwak, Shylaja Srinivasan, Ling Chen, Jennifer Todd, Josep M. Mercader, Elizabeth T. Jensen, Jasmin Divers, Amy K. Mottl, Catherine Pihoker, Rachelle G. Gandica, Lori M. Laffel, Elvira Isganaitis, Morey W. Haymond, Lynne L. Levitsky, Toni I. Pollin, Jose C. Florez, Jason Flannick
-
Metabolic heterogeneity in cancer Nat. Metab. (IF 20.8) Pub Date : 2024-01-24 Margherita Demicco, Xiao-Zheng Liu, Katharina Leithner, Sarah-Maria Fendt
-
A second step towards precision medicine in diabetes Nat. Metab. (IF 20.8) Pub Date : 2024-01-23 Xiantong Zou, Linong Ji
-
Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication Nat. Metab. (IF 20.8) Pub Date : 2024-01-23 Paula M. Miotto, Chieh-Hsin Yang, Stacey N. Keenan, William De Nardo, Cait A. Beddows, Gio Fidelito, Garron T. Dodd, Benjamin L. Parker, Andrew F. Hill, Paul R. Burton, Kim Loh, Matthew J. Watt
-
Metabolic links among milk, genes and gut Nat. Metab. (IF 20.8) Pub Date : 2024-01-22 Sheridan H. Littleton, Struan F. A. Grant
-
Variant of the lactase LCT gene explains association between milk intake and incident type 2 diabetes Nat. Metab. (IF 20.8) Pub Date : 2024-01-22 Kai Luo, Guo-Chong Chen, Yanbo Zhang, Jee-Young Moon, Jiaqian Xing, Brandilyn A. Peters, Mykhaylo Usyk, Zheng Wang, Gang Hu, Jun Li, Elizabeth Selvin, Casey M. Rebholz, Tao Wang, Carmen R. Isasi, Bing Yu, Rob Knight, Eric Boerwinkle, Robert D. Burk, Robert C. Kaplan, Qibin Qi
-
-
Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing Nat. Metab. (IF 20.8) Pub Date : 2024-01-19 Jengmin Kang, Daniel I. Benjamin, Soochi Kim, Jayesh S. Salvi, Gurkamal Dhaliwal, Richard Lam, Armon Goshayeshi, Jamie O. Brett, Ling Liu, Thomas A. Rando
-
An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis Nat. Metab. (IF 20.8) Pub Date : 2024-01-19 Juan Cruz Herrero Martín, Beñat Salegi Ansa, Gerardo Álvarez-Rivera, Sonia Domínguez-Zorita, Pilar Rodríguez-Pombo, Belén Pérez, Enrique Calvo, Alberto Paradela, David G. Miguez, Alejandro Cifuentes, José M. Cuezva, Laura Formentini
-
Career pathways, part 13 Nat. Metab. (IF 20.8) Pub Date : 2024-01-17 Alexis A. Jourdain, Feilong Wang
Following one’s passion and curiosity are major drivers for a successful career in science, and finding the right mentors and collaborators is essential in this journey. In the thirteenth part of our Career pathways series, Alexis Jourdain and Feilong Wang share their experience.
-
p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL Nat. Metab. (IF 20.8) Pub Date : 2024-01-12 Hwang Chan Yu, Yong Geun Jeon, Ann-Yae Na, Chang Yeob Han, Mi Rin Lee, Jae Do Yang, Hee Chul Yu, Jung Beom Son, Nam Doo Kim, Jae Bum Kim, Sangkyu Lee, Eun Ju Bae, Byung-Hyun Park
-
Serine synthesis promotes bone degradation Nat. Metab. (IF 20.8) Pub Date : 2024-01-10 Ryan C. Riddle, Gillian M. Choquette
-
The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression Nat. Metab. (IF 20.8) Pub Date : 2024-01-10 Steve Stegen, Karen Moermans, Ingrid Stockmans, Bernard Thienpont, Geert Carmeliet
-
Depletion of JunB increases adipocyte thermogenic capacity and ameliorates diet-induced insulin resistance Nat. Metab. (IF 20.8) Pub Date : 2024-01-08 Xing Zhang, Xiaofeng Ding, Chunqing Wang, Que Le, Dandan Wu, Anying Song, Guixiang Huang, Liping Luo, Yan Luo, Xin Yang, Aleyah E. Goins, Sharina P. Desai, Chengrui Qiu, Floyd D. Silva, Lily Elizabeth Feldman, Jianlin Zhou, Michael F. Spafford, Nathan H. Boyd, Eric R. Prossnitz, Xuexian O. Yang, Qiong A. Wang, Meilian Liu
-
Paracrine signalling by pancreatic δ cells determines the glycaemic set point in mice Nat. Metab. (IF 20.8) Pub Date : 2024-01-09 Jessica L. Huang, Mohammad S. Pourhosseinzadeh, Sharon Lee, Niels Krämer, Jaresley V. Guillen, Naomi H. Cinque, Paola Aniceto, Ariana T. Momen, Shinichiro Koike, Mark O. Huising