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Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health Nat. Metab. (IF 18.9) Pub Date : 2024-09-25 Sam M. Lockhart, Milan Muso, Ilona Zvetkova, Brian Y. H. Lam, Alessandra Ferrari, Erik Schoenmakers, Katie Duckett, Jack Leslie, Amy Collins, Beatriz Romartínez-Alonso, John A. Tadross, Raina Jia, Eugene J. Gardner, Katherine Kentistou, Yajie Zhao, Felix Day, Alexander Mörseburg, Kara Rainbow, Debra Rimmington, Matteo Mastantuoni, James Harrison, Meritxell Nus, Khalid Guma’a, Sam Sherratt-Mayhew, Xiao
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Acarbose enhances the efficacy of immunotherapy against solid tumours by modulating the gut microbiota Nat. Metab. (IF 18.9) Pub Date : 2024-09-25 Shi-Long Zhang, Xin Wang, Qing-Qing Cai, Chen Chen, Zheng-Yan Zhang, Ya-Yun Xu, Meng-Xuan Yang, Qing-An Jia, Yan Wang, Zhi-Ming Wang
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Exercise inhibits cellular senescence in pancreatic islets Nat. Metab. (IF 18.9) Pub Date : 2024-09-24 Gregory D. Cartee
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Exercise activates AMPK in mouse and human pancreatic islets to decrease senescence Nat. Metab. (IF 18.9) Pub Date : 2024-09-24 Priscila Carapeto, Kanako Iwasaki, Francesko Hela, Jiho Kahng, Ana B. Alves-Wagner, Roeland J. W. Middelbeek, Michael F. Hirshman, Guy A. Rutter, Laurie J. Goodyear, Cristina Aguayo-Mazzucato
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Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes Nat. Metab. (IF 18.9) Pub Date : 2024-09-23 Thomas G. Hill, Rui Gao, Anna Benrick, Lakshmi Kothegala, Nils Rorsman, Cristiano Santos, Samuel Acreman, Linford J. Briant, Haiqiang Dou, Nikhil R. Gandasi, Claudia Guida, Elizabeth Haythorne, Marsha Wallace, Jakob G. Knudsen, Caroline Miranda, Johan Tolö, Anne Clark, Lucy Davison, Joachim Størling, Andrei Tarasov, Frances M. Ashcroft, Patrik Rorsman, Quan Zhang
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Reply to: Milk intake, lactase non-persistence and type 2 diabetes risk in Chinese adults Nat. Metab. (IF 18.9) Pub Date : 2024-09-18 Kai Luo, Yanbo Zhang, Robert C. Kaplan, Qibin Qi
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Milk intake, lactase non-persistence and type 2 diabetes risk in Chinese adults Nat. Metab. (IF 18.9) Pub Date : 2024-09-18 Maria G. Kakkoura, Robin G. Walters, Robert Clarke, Zhengming Chen, Huaidong Du
arising from K. Luo et al. Nature Metabolism https://doi.org/10.1038/s42255-023-00961-1 (2024) In the 2024 January issue of Nature Metabolism, Luo et al.1 reported an inverse association between milk intake and risk of type 2 diabetes (T2D) among individuals who were lactase non-persistent (LNP), as determined by the lactase (LCT) rs4988235 homozygous GG genotype. The authors also reported inverse
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O-GlcNAc transferase regulates glycolytic metabolon formation on mitochondria to enhance ATP production Nat. Metab. (IF 18.9) Pub Date : 2024-09-11
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Organization of a functional glycolytic metabolon on mitochondria for metabolic efficiency Nat. Metab. (IF 18.9) Pub Date : 2024-09-11 Haoming Wang, John W. Vant, Andrew Zhang, Richard G. Sanchez, Youjun Wu, Mary L. Micou, Vincent Luczak, Zachary Whiddon, Natasha M. Carlson, Seungyoon B. Yu, Mirna Jabbo, Seokjun Yoon, Ahmed A. Abushawish, Majid Ghassemian, Takeya Masubuchi, Quan Gan, Shigeki Watanabe, Eric R. Griffis, Marc Hammarlund, Abhishek Singharoy, Gulcin Pekkurnaz
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Long-term exercise training has positive effects on adipose tissue in overweight or obesity Nat. Metab. (IF 18.9) Pub Date : 2024-09-10
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Years of endurance exercise training remodel abdominal subcutaneous adipose tissue in adults with overweight or obesity Nat. Metab. (IF 18.9) Pub Date : 2024-09-10 Cheehoon Ahn, Tao Zhang, Gayoung Yang, Thomas Rode, Pallavi Varshney, Sophia J. Ghayur, Olivia K. Chugh, Hui Jiang, Jeffrey F. Horowitz
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Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer Nat. Metab. (IF 18.9) Pub Date : 2024-09-09 Elena Buglakova, Måns Ekelöf, Michaela Schwaiger-Haber, Lisa Schlicker, Martijn R. Molenaar, Mohammed Shahraz, Lachlan Stuart, Andreas Eisenbarth, Volker Hilsenstein, Gary J. Patti, Almut Schulze, Marteinn T. Snaebjornsson, Theodore Alexandrov
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Efferocytosis drives a tryptophan metabolism pathway in macrophages to promote tissue resolution Nat. Metab. (IF 18.9) Pub Date : 2024-09-06 Santosh R. Sukka, Patrick B. Ampomah, Lancia N. F. Darville, David Ngai, Xiaobo Wang, George Kuriakose, Yuling Xiao, Jinjun Shi, John M. Koomen, Robert H. McCusker, Ira Tabas
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Career pathways, part 15 Nat. Metab. (IF 18.9) Pub Date : 2024-09-03 Marina Garcia-Macia, Fei Yin
In this new instalment of our Career Pathways series, Marina García-Macia and Fei Yin highlight the impact and joys of building a team and share with us key milestones that have shaped their careers so far, including the importance of making the most of every situation, finding the right mentors, and pursuing the questions that they are passionate about.
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Mitochondrial transplants to treat mitochondrial dysfunction Nat. Metab. (IF 18.9) Pub Date : 2024-09-02 Alessandro Bitto
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Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome Nat. Metab. (IF 18.9) Pub Date : 2024-09-02 Ritsuko Nakai, Stella Varnum, Rachael L. Field, Henyun Shi, Rocky Giwa, Wentong Jia, Samantha J. Krysa, Eva F. Cohen, Nicholas Borcherding, Russell P. Saneto, Rick C. Tsai, Masashi Suganuma, Hisashi Ohta, Takafumi Yokota, Jonathan R. Brestoff
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Global 13C tracing and metabolic flux analysis of intact human liver tissue ex vivo Nat. Metab. (IF 18.9) Pub Date : 2024-08-29 Nina Grankvist, Cecilia Jönsson, Karin Hedin, Nicolas Sundqvist, Per Sandström, Bergthor Björnsson, Arjana Begzati, Evgeniya Mickols, Per Artursson, Mohit Jain, Gunnar Cedersund, Roland Nilsson
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Feeding into cardiometabolic health Nat. Metab. (IF 18.9) Pub Date : 2024-08-27
Although Western societies are mesmerized by the power of new anti-obesity drugs, we must not forget how diet can affect metabolic outcomes. In this Focus issue, and accompanying web collection, we showcase a series of Reviews, Comments and original research articles that present up-to-date evidence on how dietary interventions can affect cardiometabolic health.
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Affinity war: PSAT1 outcompetes the rest Nat. Metab. (IF 18.9) Pub Date : 2024-08-27 Richard Possemato
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The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade Nat. Metab. (IF 18.9) Pub Date : 2024-08-27 Yijian Qiu, Olivia T. Stamatatos, Qingting Hu, Jed Ruiter Swain, Suzanne Russo, Ava Sann, Ana S. H. Costa, Sara Violante, David L. Spector, Justin R. Cross, Michael J. Lukey
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A brief guide to studying extracellular vesicle function in the context of metabolism Nat. Metab. (IF 18.9) Pub Date : 2024-08-26 Daniel Stephen Lark, Kerstin Stemmer, Wei Ying, Clair Crewe
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Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis Nat. Metab. (IF 18.9) Pub Date : 2024-08-22 Elizabeth Schneider, Kenneth J. O’Riordan, Gerard Clarke, John F. Cryan
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Regulated insulin secretion from human and mouse islets exclusively composed of β-cells Nat. Metab. (IF 18.9) Pub Date : 2024-08-21
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Regulated and adaptive in vivo insulin secretion from islets only containing β-cells Nat. Metab. (IF 18.9) Pub Date : 2024-08-21 Marta Perez-Frances, Eva Bru-Tari, Christian Cohrs, Maria Valentina Abate, Léon van Gurp, Kenichiro Furuyama, Stephan Speier, Fabrizio Thorel, Pedro L. Herrera
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On the pathogenesis of obesity: causal models and missing pieces of the puzzle Nat. Metab. (IF 18.9) Pub Date : 2024-08-20 Faidon Magkos, Thorkild I. A. Sørensen, David Raubenheimer, Nikhil V. Dhurandhar, Ruth J. F. Loos, Anja Bosy-Westphal, Christoffer Clemmensen, Mads F. Hjorth, David B. Allison, Gary Taubes, Eric Ravussin, Mark I. Friedman, Kevin D. Hall, David S. Ludwig, John R. Speakman, Arne Astrup
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A safety guide for transgenic Cre drivers in metabolism Nat. Metab. (IF 18.9) Pub Date : 2024-08-19 Carla Horvath, Christian Wolfrum, Pawel Pelczar
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Cancer tissue of origin constrains the growth and metabolism of metastases Nat. Metab. (IF 18.9) Pub Date : 2024-08-19 Sharanya Sivanand, Yetis Gultekin, Peter S. Winter, Sidney Y. Vermeulen, Konstantine M. Tchourine, Keene L. Abbott, Laura V. Danai, Florian Gourgue, Brian T. Do, Kayla Crowder, Tenzin Kunchok, Allison N. Lau, Alicia M. Darnell, Alexandria Jefferson, Satoru Morita, Dan G. Duda, Andrew J. Aguirre, Brian M. Wolpin, Nicole Henning, Virginia Spanoudaki, Laura Maiorino, Darrell J. Irvine, Omer H. Yilmaz
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GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management Nat. Metab. (IF 18.9) Pub Date : 2024-08-19 Jens Juul Holst
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Insights into optimal BMI from the GlasVEGAS study Nat. Metab. (IF 18.9) Pub Date : 2024-08-16 Chun-Kwan O, Juliana C. N. Chan
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Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study Nat. Metab. (IF 18.9) Pub Date : 2024-08-16 James McLaren, Xuan Gao, Nazim Ghouri, Dilys J. Freeman, Janice Richardson, Naveed Sattar, Jason M. R. Gill
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Homeostatic feeding in hedonic centres Nat. Metab. (IF 18.9) Pub Date : 2024-08-15 Zhe Zhao, Sarah A. Stern
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A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis Nat. Metab. (IF 18.9) Pub Date : 2024-08-15 Yiqiong Liu, Ying Wang, Zheng-dong Zhao, Guoguang Xie, Chao Zhang, Renchao Chen, Yi Zhang
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LIFR regulates cholesterol-driven bidirectional hepatocyte–neutrophil cross-talk to promote liver regeneration Nat. Metab. (IF 18.9) Pub Date : 2024-08-15 Yalan Deng, Zilong Zhao, Marisela Sheldon, Yang Zhao, Hongqi Teng, Consuelo Martinez, Jie Zhang, Chunru Lin, Yutong Sun, Fan Yao, Michael A. Curran, Hao Zhu, Li Ma
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S-acylation of ATGL is required for lipid droplet homoeostasis in hepatocytes Nat. Metab. (IF 18.9) Pub Date : 2024-08-14 Yuping Zheng, Jishun Chen, Vinitha Macwan, Charneal L. Dixon, Xinran Li, Shengjie Liu, Yuyun Yu, Pinglong Xu, Qiming Sun, Qi Hu, Wei Liu, Brian Raught, Gregory D. Fairn, Dante Neculai
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Integration of epidemiological and blood biomarker analysis links haem iron intake to increased type 2 diabetes risk Nat. Metab. (IF 18.9) Pub Date : 2024-08-13 Fenglei Wang, Andrea J. Glenn, Anne-Julie Tessier, Zhendong Mei, Danielle E. Haslam, Marta Guasch-Ferré, Deirdre K. Tobias, A. Heather Eliassen, JoAnn E. Manson, Clary Clish, Kyu Ha Lee, Eric B. Rimm, Dong D. Wang, Qi Sun, Liming Liang, Walter C. Willett, Frank B. Hu
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Ketogenic diet reshapes cancer metabolism through lysine β-hydroxybutyrylation Nat. Metab. (IF 18.9) Pub Date : 2024-08-12 Junhong Qin, Xinhe Huang, Shengsong Gou, Sitao Zhang, Yujie Gou, Qian Zhang, Hongyu Chen, Lin Sun, Miaomiao Chen, Dan Liu, Cheng Han, Min Tang, Zihao Feng, Shenghui Niu, Lin Zhao, Yingfeng Tu, Zexian Liu, Weimin Xuan, Lunzhi Dai, Da Jia, Yu Xue
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Broad-spectrum antibiotics disrupt homeostatic efferocytosis Nat. Metab. (IF 18.9) Pub Date : 2024-08-09 Pedro H. V. Saavedra, Alissa J. Trzeciak, Allie Lipshutz, Andrew W. Daman, Anya J. O’Neal, Zong-Lin Liu, Zhaoquan Wang, Jesús E. Romero-Pichardo, Waleska Saitz Rojas, Giulia Zago, Marcel R. M. van den Brink, Steven Z. Josefowicz, Christopher D. Lucas, Christopher J. Anderson, Alexander Y. Rudensky, Justin S. A. Perry
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Host–microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency Nat. Metab. (IF 18.9) Pub Date : 2024-08-08 Yong-Uk Lee, Bennett W. Fox, Rui Guo, Brian J. Curtis, Jingfang Yu, Sookyung Kim, Shivani Nanda, Victor Baumann, L. Safak Yilmaz, Cole M. Haynes, Frank C. Schroeder, Albertha J. M. Walhout
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Exploring pancreatic beta-cell subgroups and their connectivity Nat. Metab. (IF 18.9) Pub Date : 2024-08-08 Guy A. Rutter, Anne Gresch, Luis Delgadillo Silva, Richard K. P. Benninger
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The dual action of basal forebrain in feeding regulation Nat. Metab. (IF 18.9) Pub Date : 2024-08-07 Yu Fu
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Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice Nat. Metab. (IF 18.9) Pub Date : 2024-08-07 Hailan Liu, Jonathan C. Bean, Yongxiang Li, Meng Yu, Olivia Z. Ginnard, Kristine M. Conde, Mengjie Wang, Xing Fang, Hesong Liu, Longlong Tu, Na Yin, Junying Han, Yongjie Yang, Qingchun Tong, Benjamin R. Arenkiel, Chunmei Wang, Yang He, Yong Xu
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Metabolic Messengers: itaconate Nat. Metab. (IF 18.9) Pub Date : 2024-07-26 A. F. McGettrick, L. A. Bourner, F. C. Dorsey, L. A. J. O’Neill
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Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging Nat. Metab. (IF 18.9) Pub Date : 2024-07-25 Zimeng Cai, Qiaoling Zhong, Yanqiu Feng, Qian Wang, Zuoman Zhang, Cailv Wei, Zhinan Yin, Changhong Liang, Chong Wee Liew, Lawrence Kazak, Aaron M. Cypess, Zaiyi Liu, Kejia Cai
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Complex roles for mitochondrial complexes in microglia Nat. Metab. (IF 18.9) Pub Date : 2024-07-24 Rosa C. Paolicelli, Stefano Pluchino
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Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality Nat. Metab. (IF 18.9) Pub Date : 2024-07-24 Bella Mora-Romero, Nicolas Capelo-Carrasco, Juan J. Pérez-Moreno, María I. Alvarez-Vergara, Laura Trujillo-Estrada, Carmen Romero-Molina, Emilio Martinez-Marquez, Noelia Morano-Catalan, Marisa Vizuete, Jose Lopez-Barneo, Jose L. Nieto-Gonzalez, Pablo Garcia-Junco-Clemente, Javier Vitorica, Antonia Gutierrez, David Macias, Alicia E. Rosales-Nieves, Alberto Pascual
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Mitochondrial respiration in microglia is essential for response to demyelinating injury but not proliferation Nat. Metab. (IF 18.9) Pub Date : 2024-07-24 Joshua S. Stoolman, Rogan A. Grant, Taylor A. Poor, Samuel E. Weinberg, Karis B. D’Alessandro, Jerica Tan, Jennifer Yuan-Shih Hu, Megan E. Zerrer, Walter A. Wood, Madeline C. Harding, Sahil Soni, Karen M. Ridge, Paul T. Schumacker, G. R. Scott Budinger, Navdeep S. Chandel
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H2S as a metabolic saboteur Nat. Metab. (IF 18.9) Pub Date : 2024-07-19 Naisi Zhao, Guojun Wu, Liping Zhao
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Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice Nat. Metab. (IF 18.9) Pub Date : 2024-07-19 Qingqing Qi, Huijie Zhang, Zheyu Jin, Changchun Wang, Mengyu Xia, Bandy Chen, Bomin Lv, Ludmila Peres Diaz, Xue Li, Ru Feng, Mengdi Qiu, Yang Li, David Meseguer, Xiaojiao Zheng, Wei Wang, Wei Song, He Huang, Hao Wu, Lei Chen, Marc Schneeberger, Xiaofei Yu
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Adipose glutaminolysis resurfaces in metabolic disease Nat. Metab. (IF 18.9) Pub Date : 2024-07-15 John A. Haley, David A. Guertin
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Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health Nat. Metab. (IF 18.9) Pub Date : 2024-07-15 Simon Lecoutre, Salwan Maqdasy, David Rizo-Roca, Gianluca Renzi, Ivan Vlassakev, Lynn M. Alaeddine, Romane Higos, Jutta Jalkanen, Jiawei Zhong, Danae S. Zareifi, Scott Frendo-Cumbo, Lucas Massier, Ondrej Hodek, Marta Juvany, Thomas Moritz, Thais de Castro Barbosa, Muhmmad Omar-Hmeadi, Marta López-Yus, Fatiha Merabtene, Jimon Boniface Abatan, Geneviève Marcelin, Elie-Julien El Hachem, Christine Rouault
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Obesity-induced inflammation: connecting the periphery to the brain Nat. Metab. (IF 18.9) Pub Date : 2024-07-12 Ophélia Le Thuc, Cristina García-Cáceres
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Emerging tools and best practices for studying gut microbial community metabolism Nat. Metab. (IF 18.9) Pub Date : 2024-07-03 Cecilia Noecker, Peter J. Turnbaugh
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PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels Nat. Metab. (IF 18.9) Pub Date : 2024-07-03 Qingzhang Zhu, Shiuhwei Chen, Jan-Bernd Funcke, Leon G. Straub, Qian Lin, Shangang Zhao, Chanmin Joung, Zhuzhen Zhang, Dae-Seok Kim, Na Li, Christy M. Gliniak, Charlotte Lee, Alberto Cebrian-Serrano, Line Pedersen, Nils Halberg, Ruth Gordillo, Christine M. Kusminski, Philipp E. Scherer
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Towards nutrition with precision: unlocking biomarkers as dietary assessment tools Nat. Metab. (IF 18.9) Pub Date : 2024-07-02 Cătălina Cuparencu, Tuğçe Bulmuş-Tüccar, Jan Stanstrup, Giorgia La Barbera, Henrik M. Roager, Lars O. Dragsted
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Time of sample collection is critical for the replicability of microbiome analyses Nat. Metab. (IF 18.9) Pub Date : 2024-07-01 Celeste Allaband, Amulya Lingaraju, Stephany Flores Ramos, Tanya Kumar, Haniyeh Javaheri, Maria D. Tiu, Ana Carolina Dantas Machado, R. Alexander Richter, Emmanuel Elijah, Gabriel G. Haddad, Vanessa A. Leone, Pieter C. Dorrestein, Rob Knight, Amir Zarrinpar
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Author Correction: ASS1 metabolically contributes to the nuclear and cytosolic p53-mediated DNA damage response. Nat. Metab. (IF 18.9) Pub Date : 2024-07-01 Lisha Qiu Jin Lim,Lital Adler,Emma Hajaj,Leandro R Soria,Rotem Ben-Tov Perry,Naama Darzi,Ruchama Brody,Noa Furth,Michal Lichtenstein,Elizabeta Bab-Dinitz,Ziv Porat,Tevie Melman,Alexander Brandis,Sergey Malitsky,Maxim Itkin,Yael Aylon,Shifra Ben-Dor,Irit Orr,Amir Pri-Or,Rony Seger,Yoav Shaul,Eytan Ruppin,Moshe Oren,Minervo Perez,Jordan Meier,Nicola Brunetti-Pierri,Efrat Shema,Igor Ulitsky,Ayelet Erez
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Author Correction: Every islet matters: improving the impact of human islet research. Nat. Metab. (IF 18.9) Pub Date : 2024-07-01 Anna L Gloyn,Mark Ibberson,Piero Marchetti,Alvin C Powers,Patrik Rorsman,Maike Sander,Michele Solimena
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The dance of gut microbes on the keto diet Nat. Metab. (IF 18.9) Pub Date : 2024-06-27 Jihyun Kim, Ara Koh
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Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption Nat. Metab. (IF 18.9) Pub Date : 2024-06-27 Xiao Li, Jie Yang, Xiaofeng Zhou, Chen Dai, Mengmeng Kong, Linshan Xie, Chenglin Liu, Yilian Liu, Dandan Li, Xiaonan Ma, Yuxiang Dai, Yan Sun, Zhijie Jian, Xiaohuan Guo, Xu Lin, Yixue Li, Liang Sun, Xin Liu, Li Jin, Huiru Tang, Yan Zheng, Shangyu Hong