Here we reflect on touching points between basic science and clinical research, while highlighting key points to consider when submitting clinical work to our journal.

Spatial metabolomics has matured and is driving innovation in mass spectrometry, metabolomics and spatial omics. With exciting discoveries, complementary capabilities and increasing accessibility, it has secured its place in the spatial biology toolbox, showing promise in biology, medicine and pharmacology.

Monzel et al.1 propose specific terminology inspired by several branches of biomedicine and life sciences to foster greater precision when discussing mitochondria, while labelling terms such as function and dysfunction as ‘misnomers’. We agree with some of the aspects presented in this organizational paradigm, as it provides direction on defining various mitochondrial phenotypes. However, we also contend

Yang et al.1 have recently shown that the hypothalamus preoptic area (POA) can be stimulated via a remote source of ultrasound applied to the skull of mice or rats. The effect of this stimulation was a decrease in oxygen consumption (\(\dot{\mathrm{V}}\)O2), resulting in hypothermia and torpor in the mice, and a reduction in \(\dot{\mathrm{V}}\)O2, without torpor, in the rats. This acute and fast decline

Metabolic networks in microbial organisms are highly diverse. Unravelling this metabolic flexibility not only reveals fundamental metabolic insights but also can yield benefits for society at large

Reproducibility and replication are cornerstones of scientific research and depend on detailed reporting of experimental conditions. Here, we discuss key points and editorial policies that authors need to be aware of when submitting an article to Nature Metabolism.