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Conversion of a dietary fructose: new clues from the gut microbiome Nat. Metab. Pub Date : 2020-03-18 Catherine Postic
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Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism Nat. Metab. Pub Date : 2020-03-16 Gurpreet S. Baht; Akshay Bareja; David E. Lee; Rajesh R. Rao; Rong Huang; Janet L. Huebner; David B. Bartlett; Cory R. Hart; Jason R. Gibson; Ian R. Lanza; Virginia B. Kraus; Simon G. Gregory; Bruce M. Spiegelman; James P. White
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Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis Nat. Metab. Pub Date : 2020-03-16 Shi-Ting Li; De Huang; Shengqi Shen; Yongping Cai; Songge Xing; Gongwei Wu; Zetan Jiang; Yijie Hao; Mengqiu Yuan; Nana Wang; Lianbang Zhu; Ronghui Yan; Dongdong Yang; Lin Wang; Zhaoji Liu; Xin Hu; Rongbin Zhou; Kun Qu; Ailing Li; Xiaotao Duan; Huafeng Zhang; Ping Gao
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A macrophage-derived adipokine supports skeletal muscle regeneration Nat. Metab. Pub Date : 2020-03-16 Bénédicte Chazaud
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Childhood obesity and the associated rise in cardiometabolic complications Nat. Metab. Pub Date : 2020-03-16 Sonia Caprio; Nicola Santoro; Ram Weiss
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Giving E. coli a newfound appetite for formate Nat. Metab. Pub Date : 2020-03-09 Mary E. Lidstrom; Jue Wang
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Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity Nat. Metab. Pub Date : 2020-03-09 Fernando F. Anhê; Benjamin Anderschou Holbech Jensen; Thibault V. Varin; Florence Servant; Sebastian Van Blerk; Denis Richard; Simon Marceau; Michael Surette; Laurent Biertho; Benjamin Lelouvier; Jonathan D. Schertzer; André Tchernof; André Marette
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Microbial signatures in metabolic tissues: a novel paradigm for obesity and diabetes? Nat. Metab. Pub Date : 2020-03-09 Patrice D. Cani; Matthias Van Hul
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PTH hypersecretion triggered by a GABA B1 and Ca 2+ -sensing receptor heterocomplex in hyperparathyroidism Nat. Metab. Pub Date : 2020-03-09 Wenhan Chang; Chia-Ling Tu; Frederic G. Jean-Alphonse; Amanda Herberger; Zhiqiang Cheng; Jenna Hwong; Hanson Ho; Alfred Li; Dawei Wang; Hongda Liu; Alex D. White; Insoo Suh; Wen Shen; Quan-Yang Duh; Elham Khanafshar; Dolores M. Shoback; Kunhong Xiao; Jean-Pierre Vilardaga
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MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis Nat. Metab. Pub Date : 2020-03-09 Chien-Kuang Cornelia Ding; Joshua Rose; Tianai Sun; Jianli Wu; Po-Han Chen; Chao-Chieh Lin; Wen-Hsuan Yang; Kai-Yuan Chen; Hana Lee; Emily Xu; Sarah Tian; Jadesola Akinwuntan; Jinshi Zhao; Ziqiang Guan; Pei Zhou; Jen-Tsan Chi
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Cracking the enigma of mitochondrial-DNA variants and cancer Nat. Metab. Pub Date : 2020-03-05 Wei Wei; Patrick F. Chinnery
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Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression Nat. Metab. Pub Date : 2020-02-20 Alisson C. Cardoso; Nicholas T. Lam; Jainy J. Savla; Yuji Nakada; Ana Helena M. Pereira; Abdallah Elnwasany; Ivan Menendez-Montes; Emily L. Ensley; Ursa Bezan Petric; Gaurav Sharma; A. Dean Sherry; Craig R. Malloy; Chalermchai Khemtong; Michael T. Kinter; Wilson Lek Wen Tan; Chukwuemeka G. Anene-Nzelu; Roger Sik-Yin Foo; Ngoc Uyen Nhi Nguyen; Shujuan Li; Mahmoud Salama Ahmed; Waleed M. Elhelaly; Salim
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Targeted pharmacological therapy restores β-cell function for diabetes remission Nat. Metab. Pub Date : 2020-02-20 Stephan Sachs; Aimée Bastidas-Ponce; Sophie Tritschler; Mostafa Bakhti; Anika Böttcher; Miguel A. Sánchez-Garrido; Marta Tarquis-Medina; Maximilian Kleinert; Katrin Fischer; Sigrid Jall; Alexandra Harger; Erik Bader; Sara Roscioni; Siegfried Ussar; Annette Feuchtinger; Burcak Yesildag; Aparna Neelakandhan; Christine B. Jensen; Marion Cornu; Bin Yang; Brian Finan; Richard D. DiMarchi; Matthias H. Tschöp;
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More is better: combinatorial therapy to restore β-cell function in diabetes Nat. Metab. Pub Date : 2020-02-20 Dario F. De Jesus; Rohit N. Kulkarni
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Enzyme engineering to fight mitochondrial diseases Nat. Metab. Pub Date : 2020-02-17 Rubén Zapata-Pérez; Riekelt H. Houtkooper
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Arousal-induced cortical activity triggers lactate release from astrocytes Nat. Metab. Pub Date : 2020-02-17 Marc Zuend; Aiman S. Saab; Matthias T. Wyss; Kim David Ferrari; Ladina Hösli; Zoe J. Looser; Jillian L. Stobart; Jordi Duran; Joan J. Guinovart; L. Felipe Barros; Bruno Weber
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Type 1 diabetes progression is associated with loss of CD3 + CD56 + regulatory T cells that control CD8 + T-cell effector functions Nat. Metab. Pub Date : 2020-02-17 Giuseppe Terrazzano; Sara Bruzzaniti; Valentina Rubino; Marianna Santopaolo; Anna Teresa Palatucci; Angela Giovazzino; Claudia La Rocca; Paola de Candia; Annibale Puca; Francesco Perna; Claudio Procaccini; Veronica De Rosa; Chiara Porcellini; Salvatore De Simone; Valentina Fattorusso; Antonio Porcellini; Enza Mozzillo; Riccardo Troncone; Adriana Franzese; Johnny Ludvigsson; Giuseppe Matarese; Giuseppina
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Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities Nat. Metab. Pub Date : 2020-02-10 Binlu Huang; Bao-liang Song; Chenqi Xu
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We need to talk about the Warburg effect Nat. Metab. Pub Date : 2020-02-03 Ralph J. DeBerardinis; Navdeep S. Chandel
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Untargeted metabolomics links glutathione to bacterial cell cycle progression. Nat. Metab. Pub Date : 2020-02-03 Johannes Hartl,Patrick Kiefer,Andreas Kaczmarczyk,Maximilian Mittelviefhaus,Fabian Meyer,Thomas Vonderach,Bodo Hattendorf,Urs Jenal,Julia A Vorholt
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High-protein diets increase cardiovascular risk by activating macrophage mTOR to suppress mitophagy. Nat. Metab. Pub Date : 2020-01-23 Xiangyu Zhang,Ismail Sergin,Trent D Evans,Se-Jin Jeong,Astrid Rodriguez-Velez,Divya Kapoor,Sunny Chen,Eric Song,Karyn B Holloway,Jan R Crowley,Slava Epelman,Conrad C Weihl,Abhinav Diwan,Daping Fan,Bettina Mittendorfer,Nathan O Stitziel,Joel D Schilling,Irfan J Lodhi,Babak Razani
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Novel mechanistic links between high-protein diets and atherosclerosis Nat. Metab. Pub Date : 2020-01-23 Hanrui Zhang; Muredach P. Reilly
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Somatostatin secretion by Na+-dependent Ca2+-induced Ca2+ release in pancreatic delta-cells. Nat. Metab. Pub Date : 2020-01-20 Elisa Vergari,Geoffrey Denwood,Albert Salehi,Quan Zhang,Julie Adam,Ahmed Alrifaiy,Ingrid Wernstedt Asterholm,Anna Benrick,Margarita V Chibalina,Lena Eliasson,Claudia Guida,Thomas G Hill,Alexander Hamilton,Reshma Ramracheya,Frank Reimann,Nils J G Rorsman,Ioannis Spilliotis,Andrei I Tarasov,Jonathan N Walker,Patrik Rorsman,Linford J B Briant
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A link between metabolic energetics and pancreatic cancer mechanosensing Nat. Metab. Pub Date : 2020-01-20 Maria V. Liberti; Kivanc Birsoy
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Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue Nat. Metab. Pub Date : 2020-01-20 Emily L. Goldberg; Irina Shchukina; Jennifer L. Asher; Sviatoslav Sidorov; Maxim N. Artyomov; Vishwa Deep Dixit
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The creatine–phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis Nat. Metab. Pub Date : 2020-01-20 Vassilis Papalazarou; Tong Zhang; Nikki R. Paul; Amelie Juin; Marco Cantini; Oliver D. K. Maddocks; Manuel Salmeron-Sanchez; Laura M. Machesky
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NAD + homeostasis in health and disease Nat. Metab. Pub Date : 2020-01-20 Elena Katsyuba; Mario Romani; Dina Hofer; Johan Auwerx
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mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress. Nat. Metab. Pub Date : 2020-01-20 Naomi X Y Ling,Adrian Kaczmarek,Ashfaqul Hoque,Elizabeth Davie,Kevin R W Ngoei,Kaitlin R Morrison,William J Smiles,Gabriella M Forte,Tingting Wang,Shervi Lie,Toby A Dite,Christopher G Langendorf,John W Scott,Jonathan S Oakhill,Janni Petersen
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Ketogenic diet and adipose tissue inflammation—a simple story? Fat chance! Nat. Metab. Pub Date : 2020-01-20 Brianna J. Stubbs; John C. Newman
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Serine racemase enhances growth of colorectal cancer by producing pyruvate from serine Nat. Metab. Pub Date : 2020-01-13 Kenji Ohshima; Satoshi Nojima; Shinichiro Tahara; Masako Kurashige; Keisuke Kawasaki; Yumiko Hori; Moyu Taniguchi; Yutaka Umakoshi; Daisuke Okuzaki; Naoki Wada; Jun-ichiro Ikeda; Eiichiro Fukusaki; Eiichi Morii
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Author Correction: Olfaction regulates organismal proteostasis and longevity via microRNA-dependent signalling Nat. Metab. Pub Date : 2020-01-03 Fabian Finger; Franziska Ottens; Alexander Springhorn; Tanja Drexel; Lucie Proksch; Sophia Metz; Luisa Cochella; Thorsten Hoppe
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. Nat. Metab. Pub Date : 2019-12-23 Jinchu Vijay,Marie-Frédérique Gauthier,Rebecca L Biswell,Daniel A Louiselle,Jeffrey J Johnston,Warren A Cheung,Bradley Belden,Albena Pramatarova,Laurent Biertho,Margaret Gibson,Marie-Michelle Simon,Haig Djambazian,,Alfredo Staffa,Guillaume Bourque,Anita Laitinen,Johanna Nystedt,Marie-Claude Vohl,Jason D Fraser,Tomi Pastinen,André Tchernof,Elin Grundberg
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Dysregulation of amyloid precursor protein impairs adipose tissue mitochondrial function and promotes obesity Nat. Metab. Pub Date : 2019-12-13 Yu A. An; Clair Crewe; Ingrid Wernstedt Asterholm; Kai Sun; Shiuhwei Chen; Fang Zhang; Mengle Shao; Jan-Bernd Funcke; Zhuzhen Zhang; Leon Straub; Jun Yoshino; Samuel Klein; Christine M. Kusminski; Philipp E. Scherer
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A biosensor for measuring NAD + levels at the point of care Nat. Metab. Pub Date : 2019-12-13 Qiuliyang Yu; Narges Pourmandi; Lin Xue; Corentin Gondrand; Sebastian Fabritz; Daniel Bardy; Luc Patiny; Elena Katsyuba; Johan Auwerx; Kai Johnsson
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Integrating the inputs that shape pancreatic islet hormone release Nat. Metab. Pub Date : 2019-12-13 Glyn M. Noguchi; Mark O. Huising
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Clogging the mitochondrial protein-entry gate promotes obesity Nat. Metab. Pub Date : 2019-12-13 Jiyao Song; Thomas Becker
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Mitochondrial DNA stress signalling protects the nuclear genome Nat. Metab. Pub Date : 2019-12-09 Zheng Wu, Sebastian Oeck, A. Phillip West, Kailash C. Mangalhara, Alva G. Sainz, Laura E. Newman, Xiao-Ou Zhang, Lizhen Wu, Qin Yan, Marcus Bosenberg, Yanfeng Liu, Parker L. Sulkowski, Victoria Tripple, Susan M. Kaech, Peter M. Glazer, Gerald S. Shadel
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Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss Nat. Metab. Pub Date : 2019-12-09 Emily A. Day, Rebecca J. Ford, Brennan K. Smith, Pedrum Mohammadi-Shemirani, Marisa R. Morrow, Robert M. Gutgesell, Rachel Lu, Amogelang R. Raphenya, Mostafa Kabiri, Andrew G. McArthur, Natalia McInnes, Sibylle Hess, Guillaume Paré, Hertzel C. Gerstein, Gregory R. Steinberg
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Teaching an old dog new tricks: metformin induces body-weight loss via GDF15 Nat. Metab. Pub Date : 2019-12-09 Maximilian Kleinert, Timo D. Müller
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Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel Nat. Metab. Pub Date : 2019-12-09 Roel P. J. Bevers, Maria Litovchenko, Adamandia Kapopoulou, Virginie S. Braman, Matthew R. Robinson, Johan Auwerx, Brian Hollis, Bart Deplancke
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Inter-organ cross-talk in metabolic syndrome Nat. Metab. Pub Date : 2019-12-09 Christina Priest, Peter Tontonoz
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Targeting macrophage immunometabolism to prevent atherosclerosis Nat. Metab. Pub Date : 2019-11-29 Luke A. J. O’Neill
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ABHD5 cleaves HDAC4 to benefit the heart Nat. Metab. Pub Date : 2019-11-15 Joshua G. Travers, Timothy A. McKinsey
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Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell Nat. Metab. Pub Date : 2019-11-15 Danusa Menegaz, D. Walker Hagan, Joana Almaça, Chiara Cianciaruso, Rayner Rodriguez-Diaz, Judith Molina, Robert M. Dolan, Matthew W. Becker, Petra C. Schwalie, Rita Nano, Fanny Lebreton, Chen Kang, Rajan Sah, Herbert Y. Gaisano, Per-Olof Berggren, Steinunn Baekkeskov, Alejandro Caicedo, Edward A. Phelps
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The lipid-droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4 Nat. Metab. Pub Date : 2019-11-15 Zegeye H. Jebessa, Kumar D. Shanmukha, Matthias Dewenter, Lorenz H. Lehmann, Chang Xu, Friederike Schreiter, Dominik Siede, Xue-Min Gong, Barbara C. Worst, Giuseppina Federico, Sven W. Sauer, Tamas Fischer, Lisa Wechselberger, Oliver J. Müller, Samuel Sossalla, Christoph Dieterich, Patrick Most, Herrmann-Josef Gröne, Cedric Moro, Monika Oberer, Guenter Haemmerle, Hugo A. Katus, Jens Tyedmers, Johannes
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SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis Nat. Metab. Pub Date : 2019-11-15 Zuojun Liu, Minxian Qian, Xiaolong Tang, Wenjing Hu, Shimin Sun, Guo Li, Shuju Zhang, Fanbiao Meng, Xinyue Cao, Jie Sun, Cheng Xu, Bing Tan, Qiuxiang Pang, Bosheng Zhao, Zimei Wang, Youfei Guan, Xiongzhong Ruan, Baohua Liu
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Publisher Correction: Excess calorie intake early in life increases susceptibility to colitis in adulthood Nat. Metab. Pub Date : 2019-11-12 Ziad Al Nabhani, Sophie Dulauroy, Emelyne Lécuyer, Bernadette Polomack, Pascal Campagne, Marion Berard, Gérard Eberl
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells Nat. Metab. Pub Date : 2019-11-11 Chenran Wang, Michael A. Haas, Fuchun Yang, Syn Yeo, Takako Okamoto, Song Chen, Jian Wen, Pranjal Sarma, David R. Plas, Jun-Lin Guan
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Why we need to curb the emerging worldwide epidemic of nonalcoholic fatty liver disease Nat. Metab. Pub Date : 2019-11-07 Anna Mae Diehl, Nathalie J. Farpour-Lambert, Liping Zhao, Herbert Tilg
Nonalcoholic fatty liver disease (NAFLD) has emerged as the most prevalent liver disease worldwide, mainly because of the massive parallel global increase in obesity. Extensive public-health and political efforts will be needed in the near future to counteract this disturbing development.
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Excess calorie intake early in life increases susceptibility to colitis in adulthood Nat. Metab. Pub Date : 2019-11-04 Ziad Al Nabhani, Sophie Dulauroy, Emelyne Lécuyer, Bernadette Polomack, Pascal Campagne, Marion Berard, Gérard Eberl
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Author Correction: Voltage-energized calcium-sensitive ATP production by mitochondria Nat. Metab. Pub Date : 2019-10-30 Andrew P. Wescott, Joseph P. Y. Kao, W. Jonathan Lederer, Liron Boyman
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism. Nat. Metab. Pub Date : 2019-05-07 Li Chen,Zhaoyue Zhang,Atsushi Hoshino,Henry D Zheng,Michael Morley,Zoltan Arany,Joshua D Rabinowitz
NADPH donates high energy electrons for antioxidant defense and reductive biosynthesis. Cytosolic NADP is recycled to NADPH by the oxidative pentose phosphate pathway (oxPPP), malic enzyme 1 (ME1) and isocitrate dehydrogenase 1 (IDH1). Here we show that any one of these routes can support cell growth, but the oxPPP is uniquely required to maintain a normal NADPH/NADP ratio, mammalian dihydrofolate
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IDOL regulates systemic energy balance through control of neuronal VLDLR expression. Nat. Metab. Pub Date : 2019-10-28 Stephen D Lee,Christina Priest,Mikael Bjursell,Jie Gao,Douglas V Arneson,In Sook Ahn,Graciel Diamante,J Edward van Veen,Megan G Massa,Anna C Calkin,Jason Kim,Harriet Andersén,Prashant Rajbhandari,Michelle Porritt,Alba Carreras,Andrea Ahnmark,Frank Seeliger,Ingela Maxvall,Pernilla Eliasson,Magnus Althage,Peter Åkerblad,Daniel Lindén,Tracy A Cole,Richard Lee,Helen Boyd,Mohammad Bohlooly-Y,Stephanie M
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Alcohol-derived acetate modulates brain function Nat. Metab. Pub Date : 2019-10-24 Alia Ghrayeb, Eyal Gottlieb, Inbal Mor
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Metabolic Messengers: ceramides Nat. Metab. Pub Date : 2019-10-24 Scott A. Summers, Bhagirath Chaurasia, William L. Holland
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A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nat. Metab. Pub Date : 2019-10-21 Oliver Hahn,Lisa F Drews,An Nguyen,Takashi Tatsuta,Lisonia Gkioni,Oliver Hendrich,Qifeng Zhang,Thomas Langer,Scott Pletcher,Michael J O Wakelam,Andreas Beyer,Sebastian Grönke,Linda Partridge
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The diet and the damage done Nat. Metab. Pub Date : 2019-10-21 Stephen J. Simpson, David G. Le Couteur
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