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Inducible antibacterial responses in macrophages Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-18 Matthew J. Sweet, Divya Ramnath, Amit Singhal, Ronan Kapetanovic
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Antigen presentation for central tolerance induction Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-18 Ludger Klein, Elisabetta Petrozziello
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Striking a balance: new perspectives on homeostatic dendritic cell maturation Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-17 Victor Bosteels, Sophie Janssens
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Using art and history to communicate immunology to a broad audience Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-16 Francesca Di Rosa
Francesca Di Rosa works on T cells and is committed to science outreach. Together with Adrian Hayday, she recently conceptualized and delivered the exhibit ‘Vaccination, a time machine’ at the Royal Society Summer Exhibition in London. Here, she shares her thoughts on how to communicate a core scientific content with artistic and historical input, according to her ‘5C’ formula.
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Mast cell BH4–serotonin metabolic network implicated in postoperative pain Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-16 Alexandra Flemming
Starkl et al. show that mast cells have a key role in the metabolic network that underlies postoperative pain and demonstrate that this can be therapeutically targeted in mouse models.
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Towards a unifying model for B-cell receptor triggering Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-10 Søren E. Degn, Pavel Tolar
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Have a cake and eat it too: the importance of metaphors in research communication Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-09 Anne Spurkland
Anne Spurkland is a professor of medicine, and her research interests include T cell activation and autoimmunity. She is also an avid baker of cakes that everyone can have and eat too, irrespective of allergies and dietary preferences. This latter passion propelled her into national fame as one of Norway’s most visible experts on immunity and viruses during the COVID-19 pandemic.
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Inflammasome components as new therapeutic targets in inflammatory disease Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-09 Rebecca C. Coll, Kate Schroder
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The renaissance of oral tolerance: merging tradition and new insights Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-06 Vuk Cerovic, Oliver Pabst, Allan McI Mowat
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Immunological studies in trans-individuals undergoing gender affirming hormone therapy Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-09-04 Anna James, Petter Brodin
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Combining spatial metabolomics and proteomics profiling of single cells Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-08-30 Mayar Allam, Ahmet F. Coskun
In this Tools of the Trade article, Mayar Allam and Ahmet Coskun describe how they combined spatial metabolomics and proteomics profiling — in a framework they call scSpaMet — to explore, at the single-cell level, how metabolic profiles vary by location and in disease.
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Redefining our vision: an updated guide to the ocular immune system Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-08-30 Mengliang Wu, Erica L. Fletcher, Holly R. Chinnery, Laura E. Downie, Scott N. Mueller
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Lipid transfer from tumour-associated macrophages supports glioblastoma Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-08-23 Kirsty Minton
Kloosterman, Erbani et al. describe a lipid-mediated, metabolic crosstalk between tumour-associated macrophages and glioblastoma cells that supports tumour growth.
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Organoids identify a role for IL-7 in coeliac disease Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-08-23 Yvonne Bordon
Organoids generated from individuals with coeliac disease identify a role for IL-7 in disease pathogenesis.
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Mechanisms of antibody-dependent enhancement of infectious disease Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-08-09 Timothy J. Wells, Tyron Esposito, Ian R. Henderson, Larisa I. Labzin
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Non-classical monocytes have the support of the whole vascular tree Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-08-08 Kirsty Minton
Thierry, Baudon et al. show that non-classical monocytes are nurtured by endothelial cell expression of CSF1 throughout the whole vascular tree.
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How neuroinflammation weakens muscles Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-29 Alexandra Flemming
Neuroinflammation in response to infection or chronic disease can cause non-neural symptoms such as fatigue and muscle pain. Yang et al. show that CNS-derived IL-6 directly regulates muscle physiology.
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Early life antibiotics have lasting effects on the lung epithelium Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-29 Lucy Bird
Transient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-propionic acid, which causes long-lasting mitochondrial damage to lung epithelial cells and increases susceptibility to airway inflammation in adult mice.
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Location matters: mapping antigen receptors within tissues Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-29 Qirong Lin, Kim Thrane, Camilla Engblom
In this Tools of the Trade article, Camilla Engblom and colleagues describe their elegant technique ‘Spatial VDJ’ to detect and map antigen receptor sequences in human tissue sections.
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CD28 co-stimulation: novel insights and applications in cancer immunotherapy Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-25 Michael T. Lotze, Scott H. Olejniczak, Dimitris Skokos
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Pyroptotic cell products promote tissue repair Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-24 Yvonne Bordon
The pyroptotic secretome can be beneficial in promoting tissue repair.
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How bile acids and the microbiota interact to shape host immunity Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-15 Michael H. Lee, Sean-Paul Nuccio, Ipsita Mohanty, Lee R. Hagey, Pieter C. Dorrestein, Hiutung Chu, Manuela Raffatellu
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Elixir for DCs Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-12 Lucy Bird
Age-associated defects in dendritic cells can be corrected by hyperactivating adjuvants containing an oxidized phospholipid to induce effective antitumour responses in mice.
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Understanding NK cell heterogeneity Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-12 Alexandra Flemming
Two papers in Nature Immunology provide a comprehensive atlas of human natural killer cells in health and in different types of cancer.
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Online immunology education for a global world Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-12 Nicolas Vabret, Jaime Mateus-Tique, Hélène Salmon, Jérôme C. Martin, Véronique Mateo, Sandra Serrano, François Lemoine, Roger Chammas, Miriam Merad
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Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-09 Isabelle C. Arnold, Ariel Munitz
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Defining myeloid-derived suppressor cells Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-05 Leila Akkari, Ido Amit, Vincenzo Bronte, Zvi G. Fridlender, Dmitry I. Gabrilovich, Florent Ginhoux, Catherine C. Hedrick, Suzanne Ostrand-Rosenberg
Myeloid-derived suppressor cells (MDSCs) are cells of neutrophil and monocyte lineages with potent immunosuppressive activity. Numerous studies in mice and humans have identified important roles for MDSCs in suppressing the antitumour response and determining the efficacy of cancer immunotherapies. However, there is still much controversy regarding their identity, ontogeny and functions that must be
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Rethinking pDCs: a questionable ally in immunity? Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-04 Ester Gea-Mallorquí, Sarah Rowland-Jones
A preprint by Ngo et al. reports a new mouse model for the constitutive depletion of pDCs, showing that pDCs are dispensable for antiviral immunity.
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Microbiota licenses protective CD8+ T cell responses against neonatal influenza Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-04 Boyan K. Tsankov, Dana J. Philpott
A preprint by Stevens et al. establishes a novel mechanism by which the gut micobiota provides protection against neonatal respiratory tract infection.
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An ILC3-intrinsic, CTLA4-dependent intestinal checkpoint Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-04 Kirsty Minton
Ahmed et al. report that IL-23-dependent CTLA4 expression by ILC3s restrains T cell-mediated inflammation in the intestine.
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Actin branching maintains tissue-resident mast cells Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-02 Louis Ngai, Arthur Mortha
A preprint by Kaltenbach et al. shows a role for cytoskeletal control mechanisms in contributing to the tissue maintenance of mast cells.
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Single-cell analysis in rheumatic and allergic diseases: insights for clinical practice Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-06-24 Masayuki Nishide, Hiroshi Shimagami, Atsushi Kumanogoh
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Engineered γδ T cells show promise in bone tumours Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-06-11 Alexandra Flemming
An adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as well as an IL-15 superagonist, controlled tumour growth in a mouse model of patient-derived osteosarcoma.
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Heart failure affects innate immune memory Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-06-11 Alexandra Flemming
A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose to further heart disease and comorbidity.
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The impact of Plasmodium-driven immunoregulatory networks on immunity to malaria Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-06-11 Michelle J. Boyle, Christian R. Engwerda, Prasanna Jagannathan
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CAR T cells take to the airways Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-06-10 Yvonne Bordon
CAR T cell therapy alleviates type 2 airway inflammation in mouse models of asthma.
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Ultra-processed foods: increasing the risk of inflammation and immune dysregulation? Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-06-03 Katherine A. Maki, Michael N. Sack, Kevin D. Hall
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Chimeric antigen receptor T cell therapy for autoimmune disease Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-06-03 James B. Chung, Jennifer N. Brudno, Dominic Borie, James N. Kochenderfer
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A guide to adaptive immune memory Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-06-03 Nora Lam, YoonSeung Lee, Donna L. Farber
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Stiff tumours exhaust T cells Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-31 Lucy Bird
CD8+ T cells become exhausted when exposed to the mechanical forces of stiff solid tumours, owing to signalling through the transcription factor OSR2.
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Author Correction: Cancer cell metabolism and antitumour immunity. Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-07-01 Mara De Martino,Jeffrey C Rathmell,Lorenzo Galluzzi,Claire Vanpouille-Box
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Breast cancer-associated fibroblasts maintain self-renewing immunosuppressive macrophages Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-24 Anthony Altieri, Matthew B. Buechler
A preprint by Ben-Chetrit et al. investigates the molecular and cellular mechanisms that regulate macrophage heterogeneity in solid breast cancer tumours.
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Intestinal tuft cells: weep, sweep … secrete Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-24 Kirsty Minton
Two papers in Immunity report the effects of acetylcholine secretion by intestinal tuft cells on epithelial cells and helminths that contribute to the anti-helminth response.
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Universal LIPSTIC: a new tool for decoding cellular interactions Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-23 Sandra Nakandakari-Higa
In this Tools of the Trade article, Sandra Nakandakari-Higa (of the Gabriel Victora lab) describes the latest version of their LIPSTIC technique for tracking diverse cell–cell interactions in vivo.
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Connecting vitamin D, the microbiome and anticancer immunity Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-14 Alexandra Flemming
Vitamin D has a role in immune modulation and in shaping commensal microbial communities. Reis e Sousa and colleagues show that mice lacking Gc globulin (Gc−/− mice), which regulates vitamin D availability, display enhanced tumour resistance. Intriguingly, co-housed wild-type mice, as well as mice that receive a faecal transfer from Gc−/− mice, also exhibit enhanced tumour immunity. The authors found
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How the brain regulates inflammation Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-14 Alexandra Flemming
Infections can activate neural circuits that mediate responses such as fever and malaise. Jin et al. describe a body-to-brain neural circuit that informs the brain of emerging inflammatory responses. Intraperitoneal injection of mice with lipopolysaccharide (LPS) or other immune insults was shown to activate specific neurons in the caudal nucleus of the solitary tract (cNST) in the brainstem. Genetic
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Time of day determines cancer immunotherapy response Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-14 Alexandra Flemming
Wang et al. show that immune cell infiltration of tumours, as well as immune cell phenotype, oscillate in a circadian manner, which can be harnessed to optimize cancer immunotherapy. In a mouse model of melanoma, the numbers of tumour infiltrating leukocytes (TILs) peaked in the evening, and this was due to fluctuating levels of the adhesion molecule ICAM-1 on endothelial cells. Treatment with chimeric
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Protect the periportals Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-08 Yvonne Bordon
Commensal bacteria induce liver macrophages that protect the tissue against inflammation.
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Atypical chemokine receptors in the immune system Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-07 Iain Comerford, Shaun R. McColl
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Defining the balance between optimal immunity and immunopathology in influenza virus infection Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-02 Thi H. O. Nguyen, Louise C. Rowntree, Brendon Y. Chua, Ryan S. Thwaites, Katherine Kedzierska
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Opportunities and challenges for T cell-based influenza vaccines Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-05-02 Tim R. Mosmann, Andrew J. McMichael, Alexandre LeVert, John W. McCauley, Jeffrey W. Almond
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DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-29 Yi Huang, Wei Jiang, Rongbin Zhou
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Noncanonical inflammasome mediates BBB breakdown Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-26 Kirsty Minton
Wei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain barrier.
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FAS signalling pathway is crucial for CAR T cell persistence Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-26 Robyn Loves, Eyal Grunebaum
A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.
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Harnessing our lived experience for science communication Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-24 Adrian Liston
Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’s books on the topic of vaccination and has developed a computer game called ‘VirusFighter’. Here, he shares his thoughts on how to become an effective science communicator.
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Weaker skin immunity in males due to androgen effects on ILC2s Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-24 Lucy Bird
Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activation of dendritic cells and thereby contributing to differences in immunity in males and females.
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Engineering immune-evasive allogeneic cellular immunotherapies Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-24 Karen E. Martin, Quirin Hammer, Karlo Perica, Michel Sadelain, Karl-Johan Malmberg
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Cancer cell metabolism and antitumour immunity Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-22 Mara De Martino, Jeffrey C. Rathmell, Lorenzo Galluzzi, Claire Vanpouille-Box
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Neuronal TLR9 signalling crucial for memory formation Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-17 Alexandra Flemming
Memories are encoded by microcircuits of hippocampal neurons. These cells undergo energy-intensive molecular adaptations during learning that can result in transient DNA damage. Jovasevic et al. show that contextual fear conditioning in mice induces the formation of double-stranded DNA (dsDNA) breaks and gene signatures of inflammation in hippocampal CA1 excitatory neurons. These cells also upregulate
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Tumour cell consumption of taurine exhausts CD8+ T cells Nat. Rev. Immunol. (IF 67.7) Pub Date : 2024-04-17 Alexandra Flemming
The amino acid taurine is marketed as a nutritional supplement. Cao et al. now show that taurine can enhance the malignant behaviour of cancer cells, but also increase the survival and effector functions of CD8+ T cells. In mouse models of gastric cancer and melanoma, intratumoural injection of taurine promoted tumour growth in immunocompromised mice, but inhibited tumour growth in immunocompetent