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Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-28 Nicholas J. Kramer, Gyan Prakash, R. Stefan Isaac, Karine Choquet, Iliana Soto, Boryana Petrova, Hope E. Merens, Naama Kanarek, L. Stirling Churchman
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Curved adhesions mediate cell attachment to soft matrix fibres in three dimensions Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-28 Wei Zhang, Chih-Hao Lu, Melissa L. Nakamoto, Ching-Ting Tsai, Anish R. Roy, Christina E. Lee, Yang Yang, Zeinab Jahed, Xiao Li, Bianxiao Cui
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The opportunities, challenges and progression of a collaborative research project Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-25 Melina Casadio
In this issue, Jason Shapiro, Hsiang-Chun (Jimmy) Chang and colleagues identify a conserved role for the iron-binding histone demethylase KDM3B in sensing iron levels and regulating mTORC1 through transcriptional repression of key components of the mTORC1 pathway. In this Q&A, we discuss this manuscript’s findings and publishing journey with first authors Jason Shapiro and Jimmy Chang and corresponding
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Iron drives anabolic metabolism through active histone demethylation and mTORC1 Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-25 Jason S. Shapiro, Hsiang-Chun Chang, Yuki Tatekoshi, Zibo Zhao, Zohra Sattar Waxali, Bong Jin Hong, Haimei Chen, Justin A. Geier, Elizabeth T. Bartom, Adam De Jesus, Farnaz K. Nejad, Amir Mahmoodzadeh, Tatsuya Sato, Lucia Ramos-Alonso, Antonia Maria Romero, Maria Teresa Martinez-Pastor, Shang-Chuan Jiang, Shiv K. Sah-Teli, Liming Li, David Bentrem, Gary Lopaschuk, Issam Ben-Sahra, Thomas V. O’Halloran
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Defining E3 ligase–substrate relationships through multiplex CRISPR screening Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-21 Richard T. Timms, Elijah L. Mena, Yumei Leng, Mamie Z. Li, Iva A. Tchasovnikarova, Itay Koren, Stephen J. Elledge
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Myc-dependent dedifferentiation of Gata6+ epidermal cells resembles reversal of terminal differentiation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-21 Miguel Bernabé-Rubio, Shahnawaz Ali, Priyanka G. Bhosale, Georgina Goss, Seyedeh Atefeh Mobasseri, Rafael Tapia-Rojo, Tong Zhu, Toru Hiratsuka, Matteo Battilocchi, Inês M. Tomás, Clarisse Ganier, Sergi Garcia-Manyes, Fiona M. Watt
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A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-18 Zsolt G. Venkei, Ildar Gainetdinov, Ayca Bagci, Margaret R. Starostik, Charlotte P. Choi, Jaclyn M. Fingerhut, Peiwei Chen, Chiraag Balsara, Troy W. Whitfield, George W. Bell, Suhua Feng, Steven E. Jacobsen, Alexei A. Aravin, John K. Kim, Phillip D. Zamore, Yukiko M. Yamashita
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Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-18 Yaping Huang, Lin Li, Geng An, Xinyan Yang, Manman Cui, Xiuling Song, Jing Lin, Xiaoling Zhang, Zhaokai Yao, Cong Wan, Cai Zhou, Jiexiang Zhao, Ke Song, Shaofang Ren, Xinyu Xia, Xin Fu, Yu Lan, Xuesong Hu, Wen Wang, Mei Wang, Yi Zheng, Kai Miao, Xiaochun Bai, Andrew P. Hutchins, Gang Chang, Shuai Gao, Xiao-Yang Zhao
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DMRT1 drives the human germline forward Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-14 Yongjie Lu, Peng Yuan, Jie Qiao
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DMRT1 regulates human germline commitment Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-14 Naoko Irie, Sun-Min Lee, Valentina Lorenzi, Haiqi Xu, Jinfeng Chen, Masato Inoue, Toshihiro Kobayashi, Carmen Sancho-Serra, Elena Drousioti, Sabine Dietmann, Roser Vento-Tormo, Chun-Xiao Song, M. Azim Surani
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A human peri-gastrulation model Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-11 Stylianos Lefkopoulos
Non-integrated models of human gastrulation lack extraembryonic tissues, hampering the study of peri-gastrulation development. Liu et al. now overcome this limitation by generating structures consisting of both embryonic and extraembryonic tissues.
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A research program at the frontier of lipid and membrane biology Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-12 Melina Casadio
Shirin Bahmanyar is an associate professor of molecular, cellular & developmental biology at Yale University, CT, USA. Shirin’s lab studies the organization of the endoplasmic reticulum (ER) and nuclear envelope, their dynamics throughout the cell cycle, and their relationship to lipid metabolism. We reached out to Shirin and were delighted to hear her thoughts on open questions in this field and to
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Collagen fibril self-assembly Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-11 Daryl J. V. David
Collagen is an abundant extracellular matrix protein. However, how precisely collagen protofilaments are assembled into ordered fibrils in vivo remains unclear. Using modelling and in vivo experimental data, Revell et al. suggest that protomeric collagen is secreted then progressively assembled extracellularly into fibrils in the mouse embryonic tail.
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Vitamin K inhibits ferroptosis via VKORC1L1 Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-11 Zhe Wang
Vitamin K has been shown to suppress ferroptosis, but the underlying mechanism remains to be fully characterized. In Cell Metabolism, Yang et al. show that VKORC1L1 is directly regulated by p53 and mediates the reduction of vitamin K to negatively regulate ferroptosis for tumour suppression.
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STING as a proton channel Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-11 Melina Casadio
The transmembrane protein stimulator of interferon genes (STING) translocates from the endoplasmic reticulum to the Golgi during STING-induced LC3B lipidation and NLRP3 inflammasome activation. However, how STING functions in the context of innate immunity and non-canonical autophagy has been unclear. Liu et al. show that STING dimers form a proton channel.
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8G modifications rewire tumoral microRNAs Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-07 Marta Montes, Maite Huarte
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Pausing pluripotency via RNA methylation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-07 Xueting Xu, Baoming Qin
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m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-07 Evelyne Collignon, Brandon Cho, Giacomo Furlan, Julie Fothergill-Robinson, Sylvia-Bryn Martin, Sarah A. McClymont, Robert L. Ross, Patrick A. Limbach, Miguel Ramalho-Santos
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Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-07 Sangkyeong Eom, Jongjin Peak, Jongyeun Park, Seung Hyun Ahn, You Kyung Cho, Yeahji Jeong, Hye-Sook Lee, Jung Lee, Elizaveta Ignatova, Sung Eun Lee, Yunji Hong, Dowoon Gu, Geun-Woo D. Kim, Dong Chan Lee, Ja Young Hahm, Jaemin Jeong, Dongho Choi, Eun-Sook Jang, Sung Wook Chi
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Depletion of p16high senescent cells for stem cell reprogramming and tissue rejuvenation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-09-04
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p16High senescence restricts cellular plasticity during somatic cell reprogramming Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-31 Bogdan B. Grigorash, Dominic van Essen, Guixian Liang, Laurent Grosse, Alexander Emelyanov, Zhixin Kang, Alexey Korablev, Benoît Kanzler, Clement Molina, Elsa Lopez, Oleg N. Demidov, Carmen Garrido, Feng Liu, Simona Saccani, Dmitry V. Bulavin
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Prioritizing diversity will help all of us Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-30 Stylianos Lefkopoulos
Kelly Stevens is an associate professor in the departments of Bioengineering and Laboratory Medicine & Pathology at the University of Washington. We spoke with her and discussed her work, her views on diversity and its importance, but also her personal struggles as an LGBT+ and disabled scientist.
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Enhancing reproducibility in human stem cell research Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-30 Stylianos Lefkopoulos
In June 2023, the International Society for Stem Cell Research (ISSCR) released a report detailing standards for human stem cell research . We spoke to the co-chairs of the Steering Committee, Tenneille Ludwig, Senior Scientist and Director of the WiCell Stem Cell Bank, and Peter W. Andrews, Emeritus Professor at the University of Sheffield, and discussed the purpose and some of the basic aspects of
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A non-coding m6A reader promotes leukaemia Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-28 James Russell, Konstantinos Tzelepis
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RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-28 Xiaoyang Dou, Yu Xiao, Chao Shen, Kitty Wang, Tong Wu, Chang Liu, Yini Li, Xianbin Yu, Jun Liu, Qing Dai, Kinga Pajdzik, Chang Ye, Ruiqi Ge, Boyang Gao, Jianhua Yu, Shuying Sun, Mengjie Chen, Jianjun Chen, Chuan He
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Epigenetic control of cancer inflammation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-21 David Corujo, Marcus Buschbeck
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MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-21 Dan Filipescu, Saul Carcamo, Aman Agarwal, Navpreet Tung, Étienne Humblin, Matthew S. Goldberg, Nikki S. Vyas, Kristin G. Beaumont, Deniz Demircioglu, Subhasree Sridhar, Flavia G. Ghiraldini, Claudia Capparelli, Andrew E. Aplin, Hélène Salmon, Robert Sebra, Alice O. Kamphorst, Miriam Merad, Dan Hasson, Emily Bernstein
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Lipid saturation controls nuclear envelope function Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-17 Anete Romanauska, Alwin Köhler
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KDM6A epigenetically regulates subtype plasticity in small cell lung cancer Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-17 Leslie Duplaquet, Yixiang Li, Matthew A. Booker, Yingtian Xie, Sarah Naomi Olsen, Radhika A. Patel, Deli Hong, Charlie Hatton, Thomas Denize, Emily Walton, Yasmin N. Laimon, Rong Li, Yijia Jiang, Roderick T. Bronson, Jackson Southard, Shuqiang Li, Sabina Signoretti, Xintao Qiu, Paloma Cejas, Scott A. Armstrong, Henry W. Long, Michael Y. Tolstorukov, Michael C. Haffner, Matthew G. Oser
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Young LINE-1 transposon 5′ UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-17 Siyan Meng, Xiaoxu Liu, Shiqi Zhu, Peng Xie, Haitong Fang, Qingyun Pan, Ke Fang, Fanfan Li, Jin Zhang, Zhuanzhuan Che, Quanyong Zhang, Guangyao Mao, Yan Wang, Ping Hu, Kai Chen, Fei Sun, Wei Xie, Zhuojuan Luo, Chengqi Lin
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Author Correction: Apical–basal polarity inhibits epithelial–mesenchymal transition and tumour metastasis by PAR-complex-mediated SNAI1 degradation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-14 Hae-Yun Jung, Laurent Fattet, Jeff H. Tsai, Taketoshi Kajimoto, Qiang Chang, Alexandra C. Newton, Jing Yang
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Balancing lysosome abundance in health and disease Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-14 Anders P. Mutvei, Michal J. Nagiec, John Blenis
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Malonyl-CoA links lipid metabolism to nutrient signalling by directly inhibiting mTORC1 Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-10
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Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-10 Raffaele Nicastro, Laura Brohée, Josephine Alba, Julian Nüchel, Gianluca Figlia, Stefanie Kipschull, Peter Gollwitzer, Jesus Romero-Pozuelo, Stephanie A. Fernandes, Andreas Lamprakis, Stefano Vanni, Aurelio A. Teleman, Claudio De Virgilio, Constantinos Demetriades
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Chemical fast track to induced pluripotency Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-07 Sebastian Memczak, Juan Carlos Izpisua Belmonte
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A fast chemical reprogramming system promotes cell identity transition through a diapause-like state Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-07 Xi Chen, Yunkun Lu, Leyun Wang, Xiaojie Ma, Jiaqi Pu, Lianyu Lin, Qian Deng, Yuhan Li, Weiyun Wang, Yan Jin, Zhensheng Hu, Ziyu Zhou, Guo Chen, Liling Jiang, Hao Wang, Xiaoyang Zhao, Xiangwei He, Junfen Fu, Holger A. Russ, Wei Li, Saiyong Zhu
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An intestinal sphingolipid confers intergenerational neuroprotection Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-03 Wenyue Wang, Tessa Sherry, Xinran Cheng, Qi Fan, Rebecca Cornell, Jie Liu, Zhicheng Xiao, Roger Pocock
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A mother to offspring metabolic link Nat. Cell Biol. (IF 21.3) Pub Date : 2023-08-03 Nicholas O. Burton
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Sphingomyelin synthase 2 foci determine sites of migrasome formation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-24
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Pioneer factor competing for fate change Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-24 Rui Yi, Yali Dou
Pioneer transcription factors bind closed chromatin regions, alter local accessibility and activate target genes. A study reveals that the SOX9 transcription factor drives cell fate switching by activating hair follicle cell enhancers, while simultaneously repressing epidermal enhancers via sequestration of epigenetic factors.
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The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-24 Yihao Yang, Nicholas Gomez, Nicole Infarinato, Rene C. Adam, Megan Sribour, Inwha Baek, Mélanie Laurin, Elaine Fuchs
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The formation of migrasomes is initiated by the assembly of sphingomyelin synthase 2 foci at the leading edge of migrating cells Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-24 Haisha Liang, Xinyu Ma, Yuanyuan Zhang, Yuheng Liu, Nan Liu, Weiying Zhang, Jianhui Chen, Boqi Liu, Wanqing Du, Xiaohui Liu, Li Yu
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From phage genetics to chromosomes as mechanical objects Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-20
Nancy Kleckner is the Herchel Smith professor of molecular biology at Harvard University. She recalls the evolution of her research interests from pure genetics, through biochemistry and molecular biology of DNA, to the roles of mechanical forces for whole-chromosome spatial patterning and dynamics.
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Spartin is a receptor for the autophagy of lipid droplets Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-20
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Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP) Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-19 Sanjay Jain, Liming Pei, Jeffrey M. Spraggins, Michael Angelo, James P. Carson, Nils Gehlenborg, Fiona Ginty, Joana P. Gonçalves, James S. Hagood, John W. Hickey, Neil L. Kelleher, Louise C. Laurent, Shin Lin, Yiing Lin, Huiping Liu, Alexandra Naba, Ernesto S. Nakayasu, Wei-Jun Qian, Andrea Radtke, Paul Robson, Brent R. Stockwell, Raf Van de Plas, Ioannis S. Vlachos, Mowei Zhou, Katy Börner, Michael
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H3K36 methylation is a reprogramming barrier Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-17 Lea Rachel Zehava Cohen, Eran Meshorer
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H3K36 methylation maintains cell identity by regulating opposing lineage programmes Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-17 Michael S. Hoetker, Masaki Yagi, Bruno Di Stefano, Justin Langerman, Simona Cristea, Lai Ping Wong, Aaron J. Huebner, Jocelyn Charlton, Weixian Deng, Chuck Haggerty, Ruslan I. Sadreyev, Alexander Meissner, Franziska Michor, Kathrin Plath, Konrad Hochedlinger
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Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-17 Joey J. Ghersi, Gabriel Baldissera, Jared Hintzen, Stephanie A. Luff, Siyuan Cheng, Ivan Fan Xia, Christopher M. Sturgeon, Stefania Nicoli
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ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-17 Chuan-Yang Dai, Chai Chee Ng, Grace Ching Ching Hung, Ina Kirmes, Laetitia A. Hughes, Yunguang Du, Christopher A. Brosnan, Arnaud Ahier, Anne Hahn, Cole M. Haynes, Oliver Rackham, Aleksandra Filipovska, Steven Zuryn
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The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-13 Jeeyun Chung, Joongkyu Park, Zon Weng Lai, Talley J. Lambert, Ruth C. Richards, Jiuchun Zhang, Tobias C. Walther, Robert V. Farese
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A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-13 J. Chen, J. A. Neil, J. P. Tan, R. Rudraraju, M. Mohenska, Y. B. Y. Sun, E. Walters, N. G. Bediaga, G. Sun, Y. Zhou, Y. Li, D. Drew, P. Pymm, W. H. Tham, F. J. Rossello, G. Nie, X. Liu, K. Subbarao, J. M. Polo
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STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2 Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-13 Liting Zhang, Congqing Jiang, Yunhong Zhong, Kongliang Sun, Huiru Jing, Jiayu Song, Jun Xie, Yaru Zhou, Mao Tian, Chuchu Zhang, Xiaona Sun, Shaowei Wang, Xi Cheng, Yuelan Zhang, Wei Wei, Xiang Li, Bishi Fu, Pinghui Feng, Bing Wu, Hong-Bing Shu, Junjie Zhang
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Transient chromatin compaction in fork restart Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-06 Susan M. Gasser
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Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-06 Chantal Alkhoury, Nathaniel F. Henneman, Volodymyr Petrenko, Yui Shibayama, Arianna Segaloni, Alexis Gadault, Ivan Nemazanyy, Edouard Le Guillou, Amare Desalegn Wolide, Konstantina Antoniadou, Xin Tong, Teruya Tamaru, Takeaki Ozawa, Muriel Girard, Karim Hnia, Dominik Lutter, Charna Dibner, Ganna Panasyuk
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Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-06 Vincent Gaggioli, Calvin S. Y. Lo, Nazaret Reverón-Gómez, Zuzana Jasencakova, Heura Domenech, Hong Nguyen, Simone Sidoli, Andrey Tvardovskiy, Sidrit Uruci, Johan A. Slotman, Yi Chai, João G. S. C. Souto Gonçalves, Eleni Maria Manolika, Ole N. Jensen, David Wheeler, Sriram Sridharan, Sanjiban Chakrabarty, Jeroen Demmers, Roland Kanaar, Anja Groth, Nitika Taneja
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Hypoxia-stabilized RIPK1 promotes cell death Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-03 Wei Ruan, Holger K. Eltzschig, Xiaoyi Yuan
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Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-03 Tao Zhang, Daichao Xu, Jianping Liu, Min Wang, Li-Juan Duan, Min Liu, Huyan Meng, Yuan Zhuang, Huibing Wang, Yingnan Wang, Mingming Lv, Zhengyi Zhang, Jia Hu, Linyu Shi, Rui Guo, Xingxing Xie, Hui Liu, Emily Erickson, Yaru Wang, Wenyu Yu, Fabin Dang, Dongxian Guan, Cong Jiang, Xiaoming Dai, Hiroyuki Inuzuka, Peiqiang Yan, Jingchao Wang, Mrigya Babuta, Gewei Lian, Zhenbo Tu, Ji Miao, Gyongyi Szabo,
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Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis Nat. Cell Biol. (IF 21.3) Pub Date : 2023-07-03 Ludovic Enkler, Viktoria Szentgyörgyi, Mirjam Pennauer, Cristina Prescianotto-Baschong, Isabelle Riezman, Aneta Wiesyk, Reut Ester Avraham, Martin Spiess, Einat Zalckvar, Roza Kucharczyk, Howard Riezman, Anne Spang