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  • De novo design of Au 36 (SR) 24 nanoclusters
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Xu Liu; Wen Wu Xu; Xinyu Huang; Endong Wang; Xiao Cai; Yue Zhao; Jin Li; Min Xiao; Chunfeng Zhang; Yi Gao; Weiping Ding; Yan Zhu

    The discovery of atomically precise nanoclusters is generally unpredictable, and the rational synthesis of nanoclusters guided by the theoretical design is still in its infancy. Here we present a de novo design of Au36(SR)24 nanoclusters, from theoretical prediction to experimental synthesis and characterization of their physicochemical properties. The crystal structure of an Au36(SR)24 nanocluster

    更新日期:2020-07-03
  • Quantum interference of currents in an atomtronic SQUID
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    C. Ryu; E. C. Samson; M. G. Boshier

    Quantum interference of currents is the most important and well known quantum phenomenon in a conventional superconducting quantum interference device (SQUID). Here, we report the observation of quantum interference of currents in an atomtronic SQUID. Analogous to a conventional SQUID, currents flowing through two junctions in an atomtronic SQUID interfere due to the phase difference from rotation

    更新日期:2020-07-03
  • Cancer immunotherapy comes of age and looks for maturity
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Amanda Finck; Saar I. Gill; Carl H. June

    As Nature Communications celebrates a 10-year anniversary, the field has witnessed the transition of cancer immunotherapy from a pipe dream to an established powerful cancer treatment modality. Here we discuss the opportunities and challenges for the future.

    更新日期:2020-07-03
  • Increasing trends in regional heatwaves
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    S. E. Perkins-Kirkpatrick; S. C. Lewis

    Heatwaves have increased in intensity, frequency and duration, with these trends projected to worsen under enhanced global warming. Understanding regional heatwave trends has critical implications for the biophysical and human systems they impact. Until now a comprehensive assessment of regional observed changes was hindered by the range of metrics employed, underpinning datasets, and time periods

    更新日期:2020-07-03
  • A Keplerian Ag 90 nest of Platonic and Archimedean polyhedra in different symmetry groups
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Yan-Min Su; Zhi Wang; Stan Schein; Chen-Ho Tung; Di Sun

    Polyhedra are ubiquitous in chemistry, biology, mathematics and other disciplines. Coordination-driven self-assembly has created molecules mimicking Platonic, Archimedean and even Goldberg polyhedra, however, nesting multiple polyhedra in one cluster is challenging, not only for synthesis but also for determining the alignment of the polyhedra. Here, we synthesize a nested Ag90 nanocluster under solvothermal

    更新日期:2020-07-03
  • Heteroatom-bridged molecular belts as containers
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Jialin Xie; Xia Li; Shenghua Wang; Anquan Li; Long Jiang; Kelong Zhu

    Hoop-shaped or belt-like molecules have been fascinating not only due to their challenging synthesis, but also unique physical and chemical properties. The incorporation of heteroatoms (N, O, S, etc.) into these belts could alter both molecular structures and electronic properties which will lead to versatile applications, from advanced host-guest systems to functional materials. Despite numerous computational

    更新日期:2020-07-03
  • Upgrading ketone synthesis direct from carboxylic acids and organohalides
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Rehanguli Ruzi; Kai Liu; Chengjian Zhu; Jin Xie

    The ketone functional group has a unique reactivity in organic chemistry and is associated with a number of useful reactions. Catalytic methods for ketone synthesis are continually being developed. Here, we report a photoredox, nickel and phosphoranyl radical synergistic cross-electrophile coupling of commercially available chemicals, aromatic acids and aryl/alkyl bromides. This allows for concise

    更新日期:2020-07-03
  • Fast three-color single-molecule FRET using statistical inference
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Janghyun Yoo; Jae-Yeol Kim; John M. Louis; Irina V. Gopich; Hoi Sung Chung

    We describe theory, experiments, and analyses of three-color Förster resonance energy transfer (FRET) spectroscopy for probing sub-millisecond conformational dynamics of protein folding and binding of disordered proteins. We devise a scheme that uses single continuous-wave laser excitation of the donor instead of alternating excitation of the donor and one of the acceptors. This scheme alleviates photophysical

    更新日期:2020-07-03
  • The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Yang Zhao; Xiang Ye; Myriam Shehata; William Dunker; Zhihang Xie; John Karijolich

    Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved RNA decay mechanism that has emerged as a potent cell-intrinsic restriction mechanism of retroviruses and positive-strand RNA viruses. However, whether NMD is capable of restricting DNA viruses is not known. The DNA virus Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi’s sarcoma and primary effusion

    更新日期:2020-07-03
  • Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Linfeng Gao; Max Emperle; Yiran Guo; Sara A. Grimm; Wendan Ren; Sabrina Adam; Hidetaka Uryu; Zhi-Min Zhang; Dongliang Chen; Jiekai Yin; Michael Dukatz; Hiwot Anteneh; Renata Z. Jurkowska; Jiuwei Lu; Yinsheng Wang; Pavel Bashtrykov; Paul A. Wade; Gang Greg Wang; Albert Jeltsch; Jikui Song

    Mammalian DNA methylation patterns are established by two de novo DNA methyltransferases, DNMT3A and DNMT3B, which exhibit both redundant and distinctive methylation activities. However, the related molecular basis remains undetermined. Through comprehensive structural, enzymology and cellular characterization of DNMT3A and DNMT3B, we here report a multi-layered substrate-recognition mechanism underpinning

    更新日期:2020-07-03
  • Anomalous 3D nanoscale photoconduction in hybrid perovskite semiconductors revealed by tomographic atomic force microscopy
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Jingfeng Song; Yuanyuan Zhou; Nitin P. Padture; Bryan D. Huey

    While grain boundaries (GBs) in conventional inorganic semiconductors are frequently considered as detrimental for photogenerated carrier transport, their exact role remains obscure for the emerging hybrid perovskite semiconductors. A primary challenge for GB-property investigations is that experimentally they need to be performed at the top surface, which is not only insensitive to depth-dependent

    更新日期:2020-07-03
  • The Seminavis robusta genome provides insights into the evolutionary adaptations of benthic diatoms
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Cristina Maria Osuna-Cruz; Gust Bilcke; Emmelien Vancaester; Sam De Decker; Atle M. Bones; Per Winge; Nicole Poulsen; Petra Bulankova; Bram Verhelst; Sien Audoor; Darja Belisova; Aikaterini Pargana; Monia Russo; Frederike Stock; Emilio Cirri; Tore Brembu; Georg Pohnert; Gwenael Piganeau; Maria Immacolata Ferrante; Thomas Mock; Lieven Sterck; Koen Sabbe; Lieven De Veylder; Wim Vyverman; Klaas Vandepoele

    Benthic diatoms are the main primary producers in shallow freshwater and coastal environments, fulfilling important ecological functions such as nutrient cycling and sediment stabilization. However, little is known about their evolutionary adaptations to these highly structured but heterogeneous environments. Here, we report a reference genome for the marine biofilm-forming diatom Seminavis robusta

    更新日期:2020-07-03
  • Boosting hydrogen evolution on MoS 2 via co-confining selenium in surface and cobalt in inner layer
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Zhilong Zheng; Liang Yu; Meng Gao; Xiya Chen; Wu Zhou; Chao Ma; Lihui Wu; Junfa Zhu; Xiangyu Meng; Jingting Hu; Yunchuan Tu; Sisi Wu; Jun Mao; Zhongqun Tian; Dehui Deng

    The lack of highly efficient, inexpensive catalysts severely hinders large-scale application of electrochemical hydrogen evolution reaction (HER) for producing hydrogen. MoS2 as a low-cost candidate suffers from low catalytic performance. Herein, taking advantage of its tri-layer structure, we report a MoS2 nanofoam catalyst co-confining selenium in surface and cobalt in inner layer, exhibiting an

    更新日期:2020-07-03
  • Recent accelerated diversification in rosids occurred outside the tropics
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Miao Sun; Ryan A. Folk; Matthew A. Gitzendanner; Pamela S. Soltis; Zhiduan Chen; Douglas E. Soltis; Robert P. Guralnick

    Conflicting relationships have been found between diversification rate and temperature across disparate clades of life. Here, we use a supermatrix comprising nearly 20,000 species of rosids—a clade of ~25% of all angiosperm species—to understand global patterns of diversification and its climatic association. Our approach incorporates historical global temperature, assessment of species’ temperature

    更新日期:2020-07-03
  • Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Keisuke Mochida; Akinori Yamasaki; Kazuaki Matoba; Hiromi Kirisako; Nobuo N. Noda; Hitoshi Nakatogawa

    The endoplasmic reticulum (ER) is selectively degraded by autophagy (ER-phagy) through proteins called ER-phagy receptors. In Saccharomyces cerevisiae, Atg40 acts as an ER-phagy receptor to sequester ER fragments into autophagosomes by binding Atg8 on forming autophagosomal membranes. During ER-phagy, parts of the ER are morphologically rearranged, fragmented, and loaded into autophagosomes, but the

    更新日期:2020-07-03
  • Automated design of a convolutional neural network with multi-scale filters for cost-efficient seismic data classification
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Zhi Geng; Yanfei Wang

    Geoscientists mainly identify subsurface geologic features using exploration-derived seismic data. Classification or segmentation of 2D/3D seismic images commonly relies on conventional deep learning methods for image recognition. However, complex reflections of seismic waves tend to form high-dimensional and multi-scale signals, making traditional convolutional neural networks (CNNs) computationally

    更新日期:2020-07-03
  • Stable machine-learning parameterization of subgrid processes for climate modeling at a range of resolutions
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Janni Yuval; Paul A. O’Gorman

    Global climate models represent small-scale processes such as convection using subgrid models known as parameterizations, and these parameterizations contribute substantially to uncertainty in climate projections. Machine learning of new parameterizations from high-resolution model output is a promising approach, but such parameterizations have been prone to issues of instability and climate drift

    更新日期:2020-07-03
  • Predicting and affecting response to cancer therapy based on pathway-level biomarkers
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Rotem Ben-Hamo; Adi Jacob Berger; Nancy Gavert; Mendy Miller; Guy Pines; Roni Oren; Eli Pikarsky; Cyril H. Benes; Tzahi Neuman; Yaara Zwang; Sol Efroni; Gad Getz; Ravid Straussman

    Identifying robust, patient-specific, and predictive biomarkers presents a major obstacle in precision oncology. To optimize patient-specific therapeutic strategies, here we couple pathway knowledge with large-scale drug sensitivity, RNAi, and CRISPR-Cas9 screening data from 460 cell lines. Pathway activity levels are found to be strong predictive biomarkers for the essentiality of 15 proteins, including

    更新日期:2020-07-03
  • Real-time gap-free dynamic waveform spectral analysis with nanosecond resolutions through analog signal processing
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Saikrishna Reddy Konatham; Reza Maram; Luis Romero Cortés; Jun Ho Chang; Leslie Rusch; Sophie LaRochelle; Hugues Guillet de Chatellus; José Azaña

    Real-time tracking of a waveform frequency content is essential for detection and analysis of fast rare events in communications, radar, radio astronomy, spectroscopy, sensing etc. This requires a method that can provide real-time spectrum analysis (RT-SA) of high-speed waveforms in a continuous and gap-free fashion. Digital signal processing is inefficient to perform RT-SA over instantaneous frequency

    更新日期:2020-07-03
  • A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Ningfei Li; Juan Carlos Baldermann; Astrid Kibleur; Svenja Treu; Harith Akram; Gavin J. B. Elias; Alexandre Boutet; Andres M. Lozano; Bassam Al-Fatly; Bryan Strange; Juan A. Barcia; Ludvic Zrinzo; Eileen Joyce; Stephan Chabardes; Veerle Visser-Vandewalle; Mircea Polosan; Jens Kuhn; Andrea A. Kühn; Andreas Horn

    Multiple surgical targets for treating obsessive-compulsive disorder with deep brain stimulation (DBS) have been proposed. However, different targets may modulate the same neural network responsible for clinical improvement. We analyzed data from four cohorts of patients (N = 50) that underwent DBS to the anterior limb of the internal capsule (ALIC), the nucleus accumbens or the subthalamic nucleus

    更新日期:2020-07-03
  • Effects of climate change on the movement of future landfalling Texas tropical cyclones
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Pedram Hassanzadeh; Chia-Ying Lee; Ebrahim Nabizadeh; Suzana J. Camargo; Ding Ma; Laurence Y. Yeung

    The movement of tropical cyclones (TCs), particularly around the time of landfall, can substantially affect the resulting damage. Recently, trends in TC translation speed and the likelihood of stalled TCs such as Harvey have received significant attention, but findings have remained inconclusive. Here, we examine how the June-September steering wind and translation speed of landfalling Texas TCs change

    更新日期:2020-07-03
  • Ambient weathering of magnesium oxide for CO 2 removal from air
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Noah McQueen; Peter Kelemen; Greg Dipple; Phil Renforth; Jennifer Wilcox

    To avoid dangerous climate change, new technologies must remove billions of tonnes of CO2 from the atmosphere every year by mid-century. Here we detail a land-based enhanced weathering cycle utilizing magnesite (MgCO3) feedstock to repeatedly capture CO2 from the atmosphere. In this process, MgCO3 is calcined, producing caustic magnesia (MgO) and high-purity CO2. This MgO is spread over land to carbonate

    更新日期:2020-07-03
  • The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Sunyuan Zhang; Nicholas A. Williamson; Lisa Duvick; Alexander Lee; Harry T. Orr; Austin Korlin-Downs; Praseuth Yang; Yee-Foong Mok; David A. Jans; Marie A. Bogoyevitch

    The expanded polyglutamine (polyQ) tract form of ataxin-1 drives disease progression in spinocerebellar ataxia type 1 (SCA1). Although known to form distinctive intranuclear bodies, the cellular pathways and processes that polyQ-ataxin-1 influences remain poorly understood. Here we identify the direct and proximal partners constituting the interactome of ataxin-1[85Q] in Neuro-2a cells, pathways analyses

    更新日期:2020-07-03
  • Collective dipole effects in ionic transport under electric fields
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    N. Salles; L. Martin-Samos; S. de Gironcoli; L. Giacomazzi; M. Valant; A. Hemeryck; P. Blaise; B. Sklenard; N. Richard

    In the context of ionic transport in solids, the variation of a migration barrier height under electric fields is traditionally assumed to be equal to the classical electric work of a point charge that carries the transport charge. However, how reliable is this phenomenological model and how does it fare with respect to Modern Theory of Polarization? In this work, we show that such a classical picture

    更新日期:2020-07-03
  • A sequential methodology for the rapid identification and characterization of breast cancer-associated functional SNPs
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Yihan Zhao; Di Wu; Danli Jiang; Xiaoyu Zhang; Ting Wu; Jing Cui; Min Qian; Jean Zhao; Steffi Oesterreich; Wei Sun; Toren Finkel; Gang Li

    GWAS cannot identify functional SNPs (fSNP) from disease-associated SNPs in linkage disequilibrium (LD). Here, we report developing three sequential methodologies including Reel-seq (Regulatory element-sequencing) to identify fSNPs in a high-throughput fashion, SDCP-MS (SNP-specific DNA competition pulldown-mass spectrometry) to identify fSNP-bound proteins and AIDP-Wb (allele-imbalanced DNA pulldown-Western

    更新日期:2020-07-03
  • Characterization of an alternative BAK-binding site for BH3 peptides
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Kaiqin Ye; Wei X. Meng; Hongbin Sun; Bo Wu; Meng Chen; Yuan-Ping Pang; Jia Gao; Hongzhi Wang; Junfeng Wang; Scott H. Kaufmann; Haiming Dai

    Many cellular stresses are transduced into apoptotic signals through modification or up-regulation of the BH3-only subfamily of BCL2 proteins. Through direct or indirect mechanisms, these proteins activate BAK and BAX to permeabilize the mitochondrial outer membrane. While the BH3-only proteins BIM, PUMA, and tBID have been confirmed to directly activate BAK through its canonical BH3 binding groove

    更新日期:2020-07-03
  • Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Lucía Barbier-Torres; Karen A. Fortner; Paula Iruzubieta; Teresa C. Delgado; Emily Giddings; Youdinghuan Chen; Devin Champagne; David Fernández-Ramos; Daniela Mestre; Beatriz Gomez-Santos; Marta Varela-Rey; Virginia Gutiérrez de Juan; Pablo Fernández-Tussy; Imanol Zubiete-Franco; Carmelo García-Monzón; Águeda González-Rodríguez; Dhaval Oza; Felipe Valença-Pereira; Qian Fang; Javier Crespo; Patricia

    Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a major unmet need. Here, we identify MCJ (Methylation-Controlled J protein) as a target for non-alcoholic steatohepatitis (NASH), an advanced phase of NAFLD. MCJ is an endogenous negative regulator of the respiratory chain

    更新日期:2020-07-03
  • Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Yi Zhang; Yiran Guo; Sheryl M. Gough; Jinyong Zhang; Kendra R. Vann; Kuai Li; Ling Cai; Xiaobing Shi; Peter D. Aplan; Gang Greg Wang; Tatiana G. Kutateladze

    Chromosomal NUP98-PHF23 translocation is associated with an aggressive form of acute myeloid leukemia (AML) and poor survival rate. Here, we report the molecular mechanisms by which NUP98-PHF23 recognizes the histone mark H3K4me3 and is inhibited by small molecule compounds, including disulfiram that directly targets the PHD finger of PHF23 (PHF23PHD). Our data support a critical role for the PHD fingers

    更新日期:2020-07-03
  • Persistent telomere cohesion protects aged cells from premature senescence
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Kameron Azarm; Amit Bhardwaj; Eugenie Kim; Susan Smith

    Human telomeres are bound by the telomere repeat binding proteins TRF1 and TRF2. Telomere shortening in human cells leads to a DNA damage response that signals replicative senescence. While insufficient loading of TRF2 at shortened telomeres contributes to the DNA damage response in senescence, the contribution of TRF1 to senescence induction has not been determined. Here we show that counter to TRF2

    更新日期:2020-07-03
  • Subsurface chemical nanoidentification by nano-FTIR spectroscopy
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Lars Mester; Alexander A. Govyadinov; Shu Chen; Monika Goikoetxea; Rainer Hillenbrand

    Nano-FTIR spectroscopy based on Fourier transform infrared near-field spectroscopy allows for label-free chemical nanocharacterization of organic and inorganic composite surfaces. The potential capability for subsurface material analysis, however, is largely unexplored terrain. Here, we demonstrate nano-FTIR spectroscopy of subsurface organic layers, revealing that nano-FTIR spectra from thin surface

    更新日期:2020-07-03
  • An ecological framework to understand the efficacy of fecal microbiota transplantation
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Yandong Xiao; Marco Tulio Angulo; Songyang Lao; Scott T. Weiss; Yang-Yu Liu

    Human gut microbiota plays critical roles in physiology and disease. Our understanding of ecological principles that govern the dynamics and resilience of this highly complex ecosystem remains rudimentary. This knowledge gap becomes more problematic as new approaches to modifying this ecosystem, such as fecal microbiota transplantation (FMT), are being developed as therapeutic interventions. Here we

    更新日期:2020-07-03
  • Pair density wave at high magnetic fields in cuprates with charge and spin orders
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Zhenzhong Shi; P. G. Baity; J. Terzic; T. Sasagawa; Dragana Popović

    In underdoped cuprates, the interplay of the pseudogap, superconductivity, and charge and spin ordering can give rise to exotic quantum states, including the pair density wave (PDW), in which the superconducting (SC) order parameter is oscillatory in space. However, the evidence for a PDW state remains inconclusive and its broader relevance to cuprate physics is an open question. To test the interlayer

    更新日期:2020-07-03
  • Rationally inattentive intertemporal choice
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Samuel J. Gershman; Rahul Bhui

    Discounting of future rewards is traditionally interpreted as evidence for an intrinsic preference in favor of sooner rewards. However, temporal discounting can also arise from internal uncertainty in value representations of future events, if one assumes that noisy mental simulations of the future are rationally combined with prior beliefs. Here, we further develop this idea by considering how simulation

    更新日期:2020-07-03
  • C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Yu Sun; Aziz Eshov; Jeffrey Zhou; Atagun U. Isiktas; Junjie U. Guo

    Expansion of an intronic (GGGGCC)n repeat region within the C9orf72 gene is a main cause of familial amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). A hallmark of c9ALS/FTD is the accumulation of misprocessed RNAs, which are often targets of cellular RNA surveillance. Here, we show that RNA decay mechanisms involving upstream frameshift 1 (UPF1), including nonsense-mediated decay

    更新日期:2020-07-03
  • Decisions bias future choices by modifying hippocampal associative memories
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Lennart Luettgau; Claus Tempelmann; Luca Franziska Kaiser; Gerhard Jocham

    Decision-making is guided by memories of option values. However, retrieving items from memory renders them malleable. Here, we show that merely retrieving values from memory and making a choice between options is sufficient both to induce changes to stimulus-reward associations in the hippocampus and to bias future decision-making. After allowing participants to make repeated choices between reward-conditioned

    更新日期:2020-07-03
  • Diverse interactions and ecosystem engineering can stabilize community assembly
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Justin D. Yeakel; Mathias M. Pires; Marcus A. M. de Aguiar; James L. O’Donnell; Paulo R. Guimarães; Dominique Gravel; Thilo Gross

    The complexity of an ecological community can be distilled into a network, where diverse interactions connect species in a web of dependencies. Species interact directly with each other and indirectly through environmental effects, however to our knowledge the role of these ecosystem engineers has not been considered in ecological network models. Here we explore the dynamics of ecosystem assembly,

    更新日期:2020-07-03
  • Progressive nitrogen limitation across the Tibetan alpine permafrost region
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Dan Kou; Guibiao Yang; Fei Li; Xuehui Feng; Dianye Zhang; Chao Mao; Qiwen Zhang; Yunfeng Peng; Chengjun Ji; Qiuan Zhu; Yunting Fang; Xueyan Liu; Xu-Ri; Siqi Li; Jia Deng; Xunhua Zheng; Jingyun Fang; Yuanhe Yang

    The ecosystem carbon (C) balance in permafrost regions, which has a global significance in understanding the terrestrial C-climate feedback, is significantly regulated by nitrogen (N) dynamics. However, our knowledge on temporal changes in vegetation N limitation (i.e., the supply of N relative to plant N demand) in permafrost ecosystems is still limited. Based on the combination of isotopic observations

    更新日期:2020-07-03
  • Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    M. C. Wilkes; K. Siva; J. Chen; G. Varetti; M. Y. Youn; H. Chae; F. Ek; R. Olsson; T. Lundbäck; D. P. Dever; T. Nishimura; A. Narla; B. Glader; H. Nakauchi; M. H. Porteus; C. E. Repellin; H. T. Gazda; S. Lin; M. Serrano; J. Flygare; K. M. Sakamoto

    Diamond Blackfan Anemia (DBA) is a congenital bone marrow failure syndrome associated with ribosomal gene mutations that lead to ribosomal insufficiency. DBA is characterized by anemia, congenital anomalies, and cancer predisposition. Treatment for DBA is associated with significant morbidity. Here, we report the identification of Nemo-like kinase (NLK) as a potential target for DBA therapy. To identify

    更新日期:2020-07-03
  • Fully stretchable active-matrix organic light-emitting electrochemical cell array
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Jia Liu; Jiechen Wang; Zhitao Zhang; Francisco Molina-Lopez; Ging-Ji Nathan Wang; Bob C. Schroeder; Xuzhou Yan; Yitian Zeng; Oliver Zhao; Helen Tran; Ting Lei; Yang Lu; Yi-Xuan Wang; Jeffrey B.-H. Tok; Reinhold Dauskardt; Jong Won Chung; Youngjun Yun; Zhenan Bao

    Intrinsically and fully stretchable active-matrix-driven displays are an important element to skin electronics that can be applied to many emerging fields, such as wearable electronics, consumer electronics and biomedical devices. Here, we show for the first time a fully stretchable active-matrix-driven organic light-emitting electrochemical cell array. Briefly, it is comprised of a stretchable light-emitting

    更新日期:2020-07-03
  • NCLX prevents cell death during adrenergic activation of the brown adipose tissue
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Essam A. Assali; Anthony E. Jones; Michaela Veliova; Rebeca Acín-Pérez; Mahmoud Taha; Nathanael Miller; Michaël Shum; Marcus F. Oliveira; Guy Las; Marc Liesa; Israel Sekler; Orian S. Shirihai

    A sharp increase in mitochondrial Ca2+ marks the activation of brown adipose tissue (BAT) thermogenesis, yet the mechanisms preventing Ca2+ deleterious effects are poorly understood. Here, we show that adrenergic stimulation of BAT activates a PKA-dependent mitochondrial Ca2+ extrusion via the mitochondrial Na+/Ca2+ exchanger, NCLX. Adrenergic stimulation of NCLX-null brown adipocytes (BA) induces

    更新日期:2020-07-03
  • Manipulating interstitial carbon atoms in the nickel octahedral site for highly efficient hydrogenation of alkyne
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Yiming Niu; Xing Huang; Yongzhao Wang; Ming Xu; Junnan Chen; Shuliang Xu; Marc-Georg Willinger; Wei Zhang; Min Wei; Bingsen Zhang

    Light elements in the interstitial site of transition metals have strong influence on heterogeneous catalysis via either expression of surface structures or even direct participation into reaction. Interstitial atoms are generally metastable with a strong environmental dependence, setting up giant challenges in controlling of heterogeneous catalysis. Herein, we show that the desired carbon atoms can

    更新日期:2020-07-03
  • Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Jinhong Wie; Apoorva Bharthur; Morgan Wolfgang; Vinodh Narayanan; Keri Ramsey; Kimberly Aranda; Qi Zhang; Yandong Zhou; Dejian Ren

    The sodium-leak channel NALCN forms a subthreshold sodium conductance that controls the resting membrane potentials of neurons. The auxiliary subunits of the channel and their functions in mammals are largely unknown. In this study, we demonstrate that two large proteins UNC80 and UNC79 are subunits of the NALCN complex. UNC80 knockout mice are neonatal lethal. The C-terminus of UNC80 contains a domain

    更新日期:2020-07-03
  • Mapping effector genes at lupus GWAS loci using promoter Capture-C in follicular helper T cells
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Chun Su; Matthew E. Johnson; Annabel Torres; Rajan M. Thomas; Elisabetta Manduchi; Prabhat Sharma; Parul Mehra; Carole Le Coz; Michelle E. Leonard; Sumei Lu; Kenyaita M. Hodge; Alessandra Chesi; James Pippin; Neil Romberg; Struan F. A. Grant; Andrew D. Wells

    Systemic lupus erythematosus (SLE) is mediated by autoreactive antibodies that damage multiple tissues. Genome-wide association studies (GWAS) link >60 loci with SLE risk, but the causal variants and effector genes are largely unknown. We generated high-resolution spatial maps of SLE variant accessibility and gene connectivity in human follicular helper T cells (TFH), a cell type required for anti-nuclear

    更新日期:2020-07-03
  • Rational flux-tuning of Halomonas bluephagenesis for co-production of bioplastic PHB and ectoine
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Hong Ma; Yiqing Zhao; Wuzhe Huang; Lizhan Zhang; Fuqing Wu; Jianwen Ye; Guo-Qiang Chen

    Ectoine, a compatible solute synthesized by many halophiles for hypersalinity resistance, has been successfully produced by metabolically engineered Halomonas bluephagenesis, which is a bioplastic poly(3-hydroxybutyrate) producer allowing open unsterile and continuous conditions. Here we report a de novo synthesis pathway for ectoine constructed into the chromosome of H. bluephagenesis utilizing two

    更新日期:2020-07-03
  • Antagonistic odor interactions in olfactory sensory neurons are widespread in freely breathing mice
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Joseph D. Zak; Gautam Reddy; Massimo Vergassola; Venkatesh N. Murthy

    Odor landscapes contain complex blends of molecules that each activate unique, overlapping populations of olfactory sensory neurons (OSNs). Despite the presence of hundreds of OSN subtypes in many animals, the overlapping nature of odor inputs may lead to saturation of neural responses at the early stages of stimulus encoding. Information loss due to saturation could be mitigated by normalizing mechanisms

    更新日期:2020-07-03
  • Ultra-fast vortex motion in a direct-write Nb-C superconductor
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    O. V. Dobrovolskiy; D. Yu Vodolazov; F. Porrati; R. Sachser; V. M. Bevz; M. Yu Mikhailov; A. V. Chumak; M. Huth

    The ultra-fast dynamics of superconducting vortices harbors rich physics generic to nonequilibrium collective systems. The phenomenon of flux-flow instability (FFI), however, prevents its exploration and sets practical limits for the use of vortices in various applications. To suppress the FFI, a superconductor should exhibit a rarely achieved combination of properties: weak volume pinning, close-to-depairing

    更新日期:2020-07-03
  • Observation of Weyl fermions in a magnetic non-centrosymmetric crystal
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Daniel S. Sanchez; Guoqing Chang; Ilya Belopolski; Hong Lu; Jia-Xin Yin; Nasser Alidoust; Xitong Xu; Tyler A. Cochran; Xiao Zhang; Yi Bian; Songtian S. Zhang; Yi-Yuan Liu; Jie Ma; Guang Bian; Hsin Lin; Su-Yang Xu; Shuang Jia; M. Zahid Hasan

    The absence of inversion symmetry in non-centrosymmetric materials has a fundamental role in the emergence of a vast number of fascinating phenomena, like ferroelectricity, second harmonic generation, and Weyl fermions. The removal of time-reversal symmetry in such systems further extends the variety of observable magneto-electric and topological effects. Here we report the striking topological properties

    更新日期:2020-07-03
  • A thermally activated and highly miscible dopant for n-type organic thermoelectrics
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Chi-Yuan Yang; Yi-Fan Ding; Dazhen Huang; Jue Wang; Ze-Fan Yao; Chun-Xi Huang; Yang Lu; Hio-Ieng Un; Fang-Dong Zhuang; Jin-Hu Dou; Chong-an Di; Daoben Zhu; Jie-Yu Wang; Ting Lei; Jian Pei

    N-doping plays an irreplaceable role in controlling the electron concentration of organic semiconductors thus to improve performance of organic semiconductor devices. However, compared with many mature p-doping methods, n-doping of organic semiconductor is still of challenges. In particular, dopant stability/processability, counterion-semiconductor immiscibility and doping induced microstructure non-uniformity

    更新日期:2020-07-03
  • Engineering monocyte/macrophage−specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Samantha G. Scharenberg; Edina Poletto; Katherine L. Lucot; Pasqualina Colella; Adam Sheikali; Thomas J. Montine; Matthew H. Porteus; Natalia Gomez-Ospina

    Gaucher disease is a lysosomal storage disorder caused by insufficient glucocerebroside activity. Its hallmark manifestations are attributed to infiltration and inflammation by macrophages. Current therapies for Gaucher disease include life−long intravenous administration of recombinant glucocerebroside and orally-available glucosylceramide synthase inhibitors. An alternative approach is to engineer

    更新日期:2020-07-03
  • Sub-single exciton optical gain threshold in colloidal semiconductor quantum wells with gradient alloy shelling
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Nima Taghipour; Savas Delikanli; Sushant Shendre; Mustafa Sak; Mingjie Li; Furkan Isik; Ibrahim Tanriover; Burak Guzelturk; Tze Chien Sum; Hilmi Volkan Demir

    Colloidal semiconductor quantum wells have emerged as a promising material platform for use in solution-processable lasers. However, applications relying on their optical gain suffer from nonradiative Auger decay due to multi-excitonic nature of light amplification in II-VI semiconductor nanocrystals. Here, we show sub-single exciton level of optical gain threshold in specially engineered CdSe/CdS@CdZnS

    更新日期:2020-07-03
  • Heterophase fcc-2H-fcc gold nanorods
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Zhanxi Fan; Michel Bosman; Zhiqi Huang; Ye Chen; Chongyi Ling; Lin Wu; Yuriy A. Akimov; Robert Laskowski; Bo Chen; Peter Ercius; Jian Zhang; Xiaoying Qi; Min Hao Goh; Yiyao Ge; Zhicheng Zhang; Wenxin Niu; Jinlan Wang; Haimei Zheng; Hua Zhang

    The crystal phase-based heterostructures of noble metal nanomaterials are of great research interest for various applications, such as plasmonics and catalysis. However, the synthesis of unusual crystal phases of noble metals still remains a great challenge, making the construction of heterophase noble metal nanostructures difficult. Here, we report a one-pot wet-chemical synthesis of well-defined

    更新日期:2020-07-03
  • Pancreatic circulating tumor cell profiling identifies LIN28B as a metastasis driver and drug target
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Joseph W. Franses; Julia Philipp; Pavlos Missios; Irun Bhan; Ann Liu; Chittampalli Yashaswini; Eric Tai; Huili Zhu; Matteo Ligorio; Benjamin Nicholson; Elizabeth M. Tassoni; Niyati Desai; Anupriya S. Kulkarni; Annamaria Szabolcs; Theodore S. Hong; Andrew S. Liss; Carlos Fernandez-del Castillo; David P. Ryan; Shyamala Maheswaran; Daniel A. Haber; George Q. Daley; David T. Ting

    Pancreatic ductal adenocarcinoma (PDAC) lethality is due to metastatic dissemination. Characterization of rare, heterogeneous circulating tumor cells (CTCs) can provide insight into metastasis and guide development of novel therapies. Using the CTC-iChip to purify CTCs from PDAC patients for RNA-seq characterization, we identify three major correlated gene sets, with stemness genes LIN28B/KLF4, WNT5A

    更新日期:2020-07-03
  • Transcriptomic and cellular decoding of regional brain vulnerability to neurogenetic disorders
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Jakob Seidlitz; Ajay Nadig; Siyuan Liu; Richard A. I. Bethlehem; Petra E. Vértes; Sarah E. Morgan; František Váša; Rafael Romero-Garcia; François M. Lalonde; Liv S. Clasen; Jonathan D. Blumenthal; Casey Paquola; Boris Bernhardt; Konrad Wagstyl; Damon Polioudakis; Luis de la Torre-Ubieta; Daniel H. Geschwind; Joan C. Han; Nancy R. Lee; Declan G. Murphy; Edward T. Bullmore; Armin Raznahan

    Neurodevelopmental disorders have a heritable component and are associated with region specific alterations in brain anatomy. However, it is unclear how genetic risks for neurodevelopmental disorders are translated into spatially patterned brain vulnerabilities. Here, we integrated cortical neuroimaging data from patients with neurodevelopmental disorders caused by genomic copy number variations (CNVs)

    更新日期:2020-07-03
  • Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Nikolaos Louros; Gabriele Orlando; Matthias De Vleeschouwer; Frederic Rousseau; Joost Schymkowitz

    The amyloid conformation can be adopted by a variety of sequences, but the precise boundaries of amyloid sequence space are still unclear. The currently charted amyloid sequence space is strongly biased towards hydrophobic, beta-sheet prone sequences that form the core of globular proteins and by Q/N/Y rich yeast prions. Here, we took advantage of the increasing amount of high-resolution structural

    更新日期:2020-07-03
  • Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Thomas A. Ray; Kelly Cochran; Chris Kozlowski; Jingjing Wang; Graham Alexander; Martha A. Cady; William J. Spencer; Philip A. Ruzycki; Brian S. Clark; Annelies Laeremans; Ming-Xiao He; Xiaoming Wang; Emily Park; Ying Hao; Alessandro Iannaccone; Gary Hu; Olivier Fedrigo; Nikolai P. Skiba; Vadim Y. Arshavsky; Jeremy N. Kay

    Genes encoding cell-surface proteins control nervous system development and are implicated in neurological disorders. These genes produce alternative mRNA isoforms which remain poorly characterized, impeding understanding of how disease-associated mutations cause pathology. Here we introduce a strategy to define complete portfolios of full-length isoforms encoded by individual genes. Applying this

    更新日期:2020-07-03
  • Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Michael Jakob Pichler; Chihaya Yamada; Bashar Shuoker; Camila Alvarez-Silva; Aina Gotoh; Maria Louise Leth; Erwin Schoof; Toshihiko Katoh; Mikiyasu Sakanaka; Takane Katayama; Chunsheng Jin; Niclas G. Karlsson; Manimozhiyan Arumugam; Shinya Fushinobu; Maher Abou Hachem

    The early life human gut microbiota exerts life-long health effects on the host, but the mechanisms underpinning its assembly remain elusive. Particularly, the early colonization of Clostridiales from the Roseburia-Eubacterium group, associated with protection from colorectal cancer, immune- and metabolic disorders is enigmatic. Here, we describe catabolic pathways that support the growth of Roseburia

    更新日期:2020-07-03
  • Long-term droughts may drive drier tropical forests towards increased functional, taxonomic and phylogenetic homogeneity
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Jesús Aguirre-Gutiérrez; Yadvinder Malhi; Simon L. Lewis; Sophie Fauset; Stephen Adu-Bredu; Kofi Affum-Baffoe; Timothy R. Baker; Agne Gvozdevaite; Wannes Hubau; Sam Moore; Theresa Peprah; Kasia Ziemińska; Oliver L. Phillips; Imma Oliveras

    Tropical ecosystems adapted to high water availability may be highly impacted by climatic changes that increase soil and atmospheric moisture deficits. Many tropical regions are experiencing significant changes in climatic conditions, which may induce strong shifts in taxonomic, functional and phylogenetic diversity of forest communities. However, it remains unclear if and to what extent tropical forests

    更新日期:2020-07-03
  • Reconciling contrasting views on economic complexity
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Carla Sciarra; Guido Chiarotti; Luca Ridolfi; Francesco Laio

    Summarising the complexity of a country’s economy in a single number is the holy grail for scholars engaging in data-based economics. In a field where the Gross Domestic Product remains the preferred indicator for many, economic complexity measures, aiming at uncovering the productive knowledge of countries, have been stirring the pot in the past few years. The commonly used methodologies to measure

    更新日期:2020-07-03
  • Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Yan Dora Zhang; Amber N. Hurson; Haoyu Zhang; Parichoy Pal Choudhury; Douglas F. Easton; Roger L. Milne; Jacques Simard; Per Hall; Kyriaki Michailidou; Joe Dennis; Marjanka K. Schmidt; Jenny Chang-Claude; Puya Gharahkhani; David Whiteman; Peter T. Campbell; Michael Hoffmeister; Mark Jenkins; Ulrike Peters; Li Hsu; Stephen B. Gruber; Graham Casey; Stephanie L. Schmit; Tracy A. O’Mara; Amanda B. Spurdle;

    Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fourteen cancer sites to estimate the number of common susceptibility variants (polygenicity) and underlying effect-size distribution. All cancers show a

    更新日期:2020-07-03
  • Megaevolutionary dynamics and the timing of evolutionary innovation in reptiles
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-03
    Tiago R. Simões; Oksana Vernygora; Michael W. Caldwell; Stephanie E. Pierce

    The origin of phenotypic diversity among higher clades is one of the most fundamental topics in evolutionary biology. However, due to methodological challenges, few studies have assessed rates of evolution and phenotypic disparity across broad scales of time to understand the evolutionary dynamics behind the origin and early evolution of new clades. Here, we provide a total-evidence dating approach

    更新日期:2020-07-03
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