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  • Observation of the polaronic character of excitons in a two-dimensional semiconducting magnet CrI 3
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Wencan Jin; Hyun Ho Kim; Zhipeng Ye; Gaihua Ye; Laura Rojas; Xiangpeng Luo; Bowen Yang; Fangzhou Yin; Jason Shih An Horng; Shangjie Tian; Yang Fu; Gongjun Xu; Hui Deng; Hechang Lei; Adam W. Tsen; Kai Sun; Rui He; Liuyan Zhao

    Exciton dynamics can be strongly affected by lattice vibrations through electron-phonon coupling. This is rarely explored in two-dimensional magnetic semiconductors. Focusing on bilayer CrI3, we first show the presence of strong electron-phonon coupling through temperature-dependent photoluminescence and absorption spectroscopy. We then report the observation of periodic broad modes up to the 8th order

    更新日期:2020-09-22
  • IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Jesse Davila-Calderon; Neeraj N. Patwardhan; Liang-Yuan Chiu; Andrew Sugarman; Zhengguo Cai; Srinivasa R. Penutmutchu; Mei-Ling Li; Gary Brewer; Amanda E. Hargrove; Blanton S. Tolbert

    Enterovirus 71 (EV71) poses serious threats to human health, particularly in Southeast Asia, and no drugs or vaccines are available. Previous work identified the stem loop II structure of the EV71 internal ribosomal entry site as vital to viral translation and a potential target. After screening an RNA-biased library using a peptide-displacement assay, we identify DMA-135 as a dose-dependent inhibitor

    更新日期:2020-09-22
  • A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Jeannette Reinig; Frank Ruge; Martin Howard; Leonie Ringrose

    Polycomb and Trithorax group proteins maintain stable epigenetic memory of gene expression states for some genes, but many targets show highly dynamic regulation. Here we combine experiment and theory to examine the mechanistic basis of these different modes of regulation. We present a mathematical model comprising a Polycomb/Trithorax response element (PRE/TRE) coupled to a promoter and including

    更新日期:2020-09-22
  • A Cu(II)–ATP complex efficiently catalyses enantioselective Diels–Alder reactions
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Changhao Wang; Qianqian Qi; Wenying Li; Jingshuang Dang; Min Hao; Shuting Lv; Xingchen Dong; Youkun Gu; Peizhe Wu; Wenyue Zhang; Yashao Chen; Jörg S. Hartig

    Natural biomolecules have been used extensively as chiral scaffolds that bind/surround metal complexes to achieve stereoselectivity in catalytic reactions. ATP is ubiquitously found in nature as an energy-storing molecule and can complex diverse metal cations. However, in biotic reactions ATP-metal complexes are thought to function mostly as co-substrates undergoing phosphoanhydride bond cleavage reactions

    更新日期:2020-09-22
  • Summer warming explains widespread but not uniform greening in the Arctic tundra biome
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Logan T. Berner; Richard Massey; Patrick Jantz; Bruce C. Forbes; Marc Macias-Fauria; Isla Myers-Smith; Timo Kumpula; Gilles Gauthier; Laia Andreu-Hayles; Benjamin V. Gaglioti; Patrick Burns; Pentti Zetterberg; Rosanne D’Arrigo; Scott J. Goetz

    Arctic warming can influence tundra ecosystem function with consequences for climate feedbacks, wildlife and human communities. Yet ecological change across the Arctic tundra biome remains poorly quantified due to field measurement limitations and reliance on coarse-resolution satellite data. Here, we assess decadal changes in Arctic tundra greenness using time series from the 30 m resolution Landsat

    更新日期:2020-09-22
  • Tracking historical changes in trustworthiness using machine learning analyses of facial cues in paintings
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Lou Safra; Coralie Chevallier; Julie Grèzes; Nicolas Baumard

    Social trust is linked to a host of positive societal outcomes, including improved economic performance, lower crime rates and more inclusive institutions. Yet, the origins of trust remain elusive, partly because social trust is difficult to document in time. Building on recent advances in social cognition, we design an algorithm to automatically generate trustworthiness evaluations for the facial

    更新日期:2020-09-22
  • A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Chenglong You; Sijie Wu; Shijie C. Zheng; Tianyu Zhu; Han Jing; Ken Flagg; Guangyu Wang; Li Jin; Sijia Wang; Andrew E. Teschendorff

    Highly reproducible smoking-associated DNA methylation changes in whole blood have been reported by many Epigenome-Wide-Association Studies (EWAS). These epigenetic alterations could have important implications for understanding and predicting the risk of smoking-related diseases. To this end, it is important to establish if these DNA methylation changes happen in all blood cell subtypes or if they

    更新日期:2020-09-22
  • Bimetallic nickel-molybdenum/tungsten nanoalloys for high-efficiency hydrogen oxidation catalysis in alkaline electrolytes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Yu Duan; Zi-You Yu; Li Yang; Li-Rong Zheng; Chu-Tian Zhang; Xiao-Tu Yang; Fei-Yue Gao; Xiao-Long Zhang; Xingxing Yu; Ren Liu; Hong-He Ding; Chao Gu; Xu-Sheng Zheng; Lei Shi; Jun Jiang; Jun-Fa Zhu; Min-Rui Gao; Shu-Hong Yu

    Hydroxide exchange membrane fuel cells offer possibility of adopting platinum-group-metal-free catalysts to negotiate sluggish oxygen reduction reaction. Unfortunately, the ultrafast hydrogen oxidation reaction (HOR) on platinum decreases at least two orders of magnitude by switching the electrolytes from acid to base, causing high platinum-group-metal loadings. Here we show that a nickel-molybdenum

    更新日期:2020-09-22
  • Half of resources in threatened species conservation plans are allocated to research and monitoring
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Rachel T. Buxton; Stephanie Avery-Gomm; Hsein-Yung Lin; Paul A. Smith; Steven J. Cooke; Joseph R. Bennett

    Funds to combat biodiversity loss are insufficient, requiring conservation managers to make trade-offs between costs for actions to avoid further loss and costs for research and monitoring to guide effective actions. Using species’ management plans for 2328 listed species from three countries we show that 50% of species’ proposed recovery plan budgets are allocated to research and monitoring. The proportion

    更新日期:2020-09-22
  • VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    L. Francisco Lorenzo-Martín; Natalia Fernández-Parejo; Mauricio Menacho-Márquez; Sonia Rodríguez-Fdez; Javier Robles-Valero; Sonia Zumalave; Salvatore Fabbiano; Gloria Pascual; Juana M. García-Pedrero; Antonio Abad; María C. García-Macías; Nazareno González; Pablo Lorenzano-Menna; Miguel A. Pavón; Rogelio González-Sarmiento; Carmen Segrelles; Jesús M. Paramio; José M. C. Tubío; Juan P. Rodrigo; Salvador

    Regenerative proliferation capacity and poor differentiation are histological features usually linked to poor prognosis in head and neck squamous cell carcinoma (hnSCC). However, the pathways that regulate them remain ill-characterized. Here, we show that those traits can be triggered by the RHO GTPase activator VAV2 in keratinocytes present in the skin and oral mucosa. VAV2 is also required to maintain

    更新日期:2020-09-22
  • A diploid assembly-based benchmark for variants in the major histocompatibility complex
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Chen-Shan Chin; Justin Wagner; Qiandong Zeng; Erik Garrison; Shilpa Garg; Arkarachai Fungtammasan; Mikko Rautiainen; Sergey Aganezov; Melanie Kirsche; Samantha Zarate; Michael C. Schatz; Chunlin Xiao; William J. Rowell; Charles Markello; Jesse Farek; Fritz J. Sedlazeck; Vikas Bansal; Byunggil Yoo; Neil Miller; Xin Zhou; Andrew Carroll; Alvaro Martinez Barrio; Marc Salit; Tobias Marschall; Alexander

    Most human genomes are characterized by aligning individual reads to the reference genome, but accurate long reads and linked reads now enable us to construct accurate, phased de novo assemblies. We focus on a medically important, highly variable, 5 million base-pair (bp) region where diploid assembly is particularly useful - the Major Histocompatibility Complex (MHC). Here, we develop a human genome

    更新日期:2020-09-22
  • Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Heather A. McCauley; Andrea L. Matthis; Jacob R. Enriquez; Jonah T. Nichol; J. Guillermo Sanchez; William J. Stone; Nambirajan Sundaram; Michael A. Helmrath; Marshall H. Montrose; Eitaro Aihara; James M. Wells

    The ability to absorb ingested nutrients is an essential function of all metazoans and utilizes a wide array of nutrient transporters found on the absorptive enterocytes of the small intestine. A unique population of patients has previously been identified with severe congenital malabsorptive diarrhea upon ingestion of any enteral nutrition. The intestines of these patients are macroscopically normal

    更新日期:2020-09-22
  • In situ tuning of electronic structure of catalysts using controllable hydrogen spillover for enhanced selectivity
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Mi Xiong; Zhe Gao; Peng Zhao; Guofu Wang; Wenjun Yan; Shuangfeng Xing; Pengfei Wang; Jingyuan Ma; Zheng Jiang; Xingchen Liu; Jiping Ma; Jie Xu; Yong Qin

    In situ tuning of the electronic structure of active sites is a long-standing challenge. Herein, we propose a strategy by controlling the hydrogen spillover distance to in situ tune the electronic structure. The strategy is demonstrated to be feasible with the assistance of CoOx/Al2O3/Pt catalysts prepared by atomic layer deposition in which CoOx and Pt nanoparticles are separated by hollow Al2O3 nanotubes

    更新日期:2020-09-22
  • Impacts of solar intermittency on future photovoltaic reliability
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Jun Yin; Annalisa Molini; Amilcare Porporato

    As photovoltaic power is expanding rapidly worldwide, it is imperative to assess its promise under future climate scenarios. While a great deal of research has been devoted to trends in mean solar radiation, less attention has been paid to its intermittent character, a key challenge when compounded with uncertainties related to climate variability. Using both satellite data and climate model outputs

    更新日期:2020-09-22
  • Indian Ocean warming as a driver of the North Atlantic warming hole
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Shineng Hu; Alexey V. Fedorov

    Over the past century, the subpolar North Atlantic experienced slight cooling or suppressed warming, relative to the background positive temperature trends, often dubbed the North Atlantic warming hole (NAWH). The causes of the NAWH remain under debate. Here we conduct coupled ocean-atmosphere simulations to demonstrate that enhanced Indian Ocean warming, another salient feature of global warming,

    更新日期:2020-09-22
  • Ultra-sensitive and rapid detection of nucleic acids and microorganisms in body fluids using single-molecule tethering
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Wen-Chih Cheng; Troy Horn; Maya Zayats; Georges Rizk; Samuel Major; Hongying Zhu; Joseph Russell; Zhiguang Xu; Richard E. Rothman; Alfredo Celedon

    Detection of microbial nucleic acids in body fluids has become the preferred method for rapid diagnosis of many infectious diseases. However, culture-based diagnostics that are time-consuming remain the gold standard approach in certain cases, such as sepsis. New culture-free methods are urgently needed. Here, we describe Single MOLecule Tethering or SMOLT, an amplification-free and purification-free

    更新日期:2020-09-22
  • Compounding impact of severe weather events fuels marine heatwave in the coastal ocean
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    B. Dzwonkowski; J. Coogan; S. Fournier; G. Lockridge; K. Park; T. Lee

    Exposure to extreme events is a major concern in coastal regions where growing human populations and stressed natural ecosystems are at significant risk to such phenomena. However, the complex sequence of processes that transform an event from notable to extreme can be challenging to identify and hence, limit forecast abilities. Here, we show an extreme heat content event (i.e., a marine heatwave)

    更新日期:2020-09-22
  • IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Rania Dagher; Alan M. Copenhaver; Valerie Besnard; Aaron Berlin; Fatima Hamidi; Marielle Maret; Jingya Wang; Xiaotao Qu; Yashaswi Shrestha; Jincheng Wu; Gregory Gautier; Rajiv Raja; Michel Aubier; Roland Kolbeck; Alison A. Humbles; Marina Pretolani

    Evidence points to an indispensable function of macrophages in tissue regeneration, yet the underlying molecular mechanisms remain elusive. Here we demonstrate a protective function for the IL-33-ST2 axis in bronchial epithelial repair, and implicate ST2 in myeloid cell differentiation. ST2 deficiency in mice leads to reduced lung myeloid cell infiltration, abnormal alternatively activated macrophage

    更新日期:2020-09-22
  • Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Edith Hofer; Gennady V. Roshchupkin; Hieab H. H. Adams; Maria J. Knol; Honghuang Lin; Shuo Li; Habil Zare; Shahzad Ahmad; Nicola J. Armstrong; Claudia L. Satizabal; Manon Bernard; Joshua C. Bis; Nathan A. Gillespie; Michelle Luciano; Aniket Mishra; Markus Scholz; Alexander Teumer; Rui Xia; Xueqiu Jian; Thomas H. Mosley; Yasaman Saba; Lukas Pirpamer; Stephan Seiler; James T. Becker; Owen Carmichael;

    Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and

    更新日期:2020-09-22
  • Predicting heterogeneous ice nucleation with a data-driven approach
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Martin Fitzner; Philipp Pedevilla; Angelos Michaelides

    Water in nature predominantly freezes with the help of foreign materials through a process known as heterogeneous ice nucleation. Although this effect was exploited more than seven decades ago in Vonnegut’s pioneering cloud seeding experiments, it remains unclear what makes a material a good ice former. Here, we show through a machine learning analysis of nucleation simulations on a database of diverse

    更新日期:2020-09-22
  • Structural snapshots of human DNA polymerase μ engaged on a DNA double-strand break
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Andrea M. Kaminski; John M. Pryor; Dale A. Ramsden; Thomas A. Kunkel; Lars C. Pedersen; Katarzyna Bebenek

    Genomic integrity is threatened by cytotoxic DNA double-strand breaks (DSBs), which must be resolved efficiently to prevent sequence loss, chromosomal rearrangements/translocations, or cell death. Polymerase μ (Polμ) participates in DSB repair via the nonhomologous end-joining (NHEJ) pathway, by filling small sequence gaps in broken ends to create substrates ultimately ligatable by DNA Ligase IV. Here

    更新日期:2020-09-22
  • Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Ke Hou; Jing Zhao; Hui Wang; Bin Li; Kexin Li; Xinghua Shi; Kaiwei Wan; Jing Ai; Jiawei Lv; Dawei Wang; Qunxing Huang; Huayi Wang; Qin Cao; Shaoqin Liu; Zhiyong Tang

    Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer’s disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeutics. Here we design and prepare 3.3 nm L- and D-glutathione stabilized gold nanoparticles (denoted as L3.3 and D3.3, respectively). Both chiral nanoparticles are able to inhibit aggregation of

    更新日期:2020-09-22
  • Absolute configuration and host-guest binding of chiral porphyrin-cages by a combined chiroptical and theoretical approach
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Jiangkun Ouyang; Anne Swartjes; Marc Geerts; Pieter J. Gilissen; Danni Wang; Paula C. P. Teeuwen; Paul Tinnemans; Nicolas Vanthuyne; Sara Chentouf; Floris P. J. T. Rutjes; Jean-Valère Naubron; Jeanne Crassous; Johannes A. A. W. Elemans; Roeland J. M. Nolte

    Porphyrin cage-compounds are used as biomimetic models and substrate-selective catalysts in supramolecular chemistry. In this work we present the resolution of planar-chiral porphyrin cages and the determination of their absolute configuration by vibrational circular dichroism in combination with density functional theory calculations. The chiral porphyrin-cages form complexes with achiral and chiral

    更新日期:2020-09-22
  • Transferring structural knowledge across cognitive maps in humans and models
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Shirley Mark; Rani Moran; Thomas Parr; Steve W. Kennerley; Timothy E. J. Behrens

    Relations between task elements often follow hidden underlying structural forms such as periodicities or hierarchies, whose inferences fosters performance. However, transferring structural knowledge to novel environments requires flexible representations that are generalizable over particularities of the current environment, such as its stimuli and size. We suggest that humans represent structural

    更新日期:2020-09-22
  • Resequencing of 1,143 indica rice accessions reveals important genetic variations and different heterosis patterns
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Qiming Lv; Weiguo Li; Zhizhong Sun; Ning Ouyang; Xin Jing; Qiang He; Jun Wu; Jiakui Zheng; Jiatuan Zheng; Shaoqing Tang; Renshan Zhu; Yan Tian; Meijuan Duan; Yanning Tan; Dong Yu; Xiabing Sheng; Xuewu Sun; Gaofeng Jia; Hongzhen Gao; Qin Zeng; Yufei Li; Li Tang; Qiusheng Xu; Bingran Zhao; Zhiyuan Huang; Hongfeng Lu; Na Li; Jian Zhao; Lihuang Zhu; Dong Li; Longping Yuan; Dingyang Yuan

    Obtaining genetic variation information from indica rice hybrid parents and identification of loci associated with heterosis are important for hybrid rice breeding. Here, we resequence 1,143 indica accessions mostly selected from the parents of superior hybrid rice cultivars of China, identify genetic variations, and perform kinship analysis. We find different hybrid rice crossing patterns between

    更新日期:2020-09-22
  • Cryo-EM structure of the varicella-zoster virus A-capsid
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-22
    Junqing Sun; Congcong Liu; Ruchao Peng; Fu-Kun Zhang; Zhou Tong; Sheng Liu; Yi Shi; Zhennan Zhao; Wen-Bo Zeng; George Fu Gao; Hong-Jie Shen; Xiaoming Yang; Minhua Luo; Jianxun Qi; Peiyi Wang

    Varicella-zoster virus (VZV), a member of the Alphaherpesvirinae subfamily, causes severe diseases in humans of all ages. The viral capsids play critical roles in herpesvirus infection, making them potential antiviral targets. Here, we present the 3.7-Å-resolution structure of the VZV A-capsid and define the molecular determinants underpinning the assembly of this complicated viral machinery. Overall

    更新日期:2020-09-22
  • Author Correction: Fast and multiplexed superresolution imaging with DNA-PAINT-ERS
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Fehmi Civitci; Julia Shangguan; Ting Zheng; Kai Tao; Matthew Rames; John Kenison; Ying Zhang; Lei Wu; Carey Phelps; Sadik Esener; Xiaolin Nan

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-21
  • Straightforward preparation of supramolecular Janus nanorods by hydrogen bonding of end-functionalized polymers
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Shuaiyuan Han; Sandrine Pensec; Dijwar Yilmaz; Cédric Lorthioir; Jacques Jestin; Jean-Michel Guigner; Frédérick Niepceron; Jutta Rieger; François Stoffelbach; Erwan Nicol; Olivier Colombani; Laurent Bouteiller

    Janus cylinders are one-dimensional colloids that have two faces with different compositions and functionalities, and are useful as building blocks for advanced functional materials. Such anisotropic objects are difficult to prepare with nanometric dimensions. Here we describe a robust and versatile strategy to form micrometer long Janus nanorods with diameters in the 10-nanometer range, by self-assembly

    更新日期:2020-09-21
  • Intermediate-phase-assisted low-temperature formation of γ-CsPbI 3 films for high-efficiency deep-red light-emitting devices
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Chang Yi; Chao Liu; Kaichuan Wen; Xiao-Ke Liu; Hao Zhang; Yong Yu; Ning Fan; Fuxiang Ji; Chaoyang Kuang; Bo Ma; Cailing Tu; Ya Zhang; Chen Xue; Renzhi Li; Feng Gao; Wei Huang; Jianpu Wang

    Black phase CsPbI3 is attractive for optoelectronic devices, while usually it has a high formation energy and requires an annealing temperature of above 300 °C. The formation energy can be significantly reduced by adding HI in the precursor. However, the resulting films are not suitable for light-emitting applications due to the high trap densities and low photoluminescence quantum efficiencies, and

    更新日期:2020-09-21
  • Mapping cellular-scale internal mechanics in 3D tissues with thermally responsive hydrogel probes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Stephanie Mok; Sara Al Habyan; Charles Ledoux; Wontae Lee; Katherine N. MacDonald; Luke McCaffrey; Christopher Moraes

    Local tissue mechanics play a critical role in cell function, but measuring these properties at cellular length scales in living 3D tissues can present considerable challenges. Here we present thermoresponsive, smart material microgels that can be dispersed or injected into tissues and optically assayed to measure residual tissue elasticity after creep over several weeks. We first develop and characterize

    更新日期:2020-09-21
  • Dissipation of electron-beam-driven plasma wakes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Rafal Zgadzaj; T. Silva; V. K. Khudyakov; A. Sosedkin; J. Allen; S. Gessner; Zhengyan Li; M. Litos; J. Vieira; K. V. Lotov; M. J. Hogan; V. Yakimenko; M. C. Downer

    Metre-scale plasma wakefield accelerators have imparted energy gain approaching 10 gigaelectronvolts to single nano-Coulomb electron bunches. To reach useful average currents, however, the enormous energy density that the driver deposits into the wake must be removed efficiently between shots. Yet mechanisms by which wakes dissipate their energy into surrounding plasma remain poorly understood. Here

    更新日期:2020-09-21
  • Optical imaging of single-protein size, charge, mobility, and binding
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Guangzhong Ma; Zijian Wan; Yunze Yang; Pengfei Zhang; Shaopeng Wang; Nongjian Tao

    Detection and identification of proteins are typically achieved by analyzing protein size, charge, mobility and binding to antibodies, which are critical for biomedical research and disease diagnosis and treatment. Despite the importance, measuring these quantities with one technology and at the single-molecule level has not been possible. Here we tether a protein to a surface with a flexible polymer

    更新日期:2020-09-21
  • Rational programming of history-dependent logic in cellular populations
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Ana Zúñiga; Sarah Guiziou; Pauline Mayonove; Zachary Ben Meriem; Miguel Camacho; Violaine Moreau; Luca Ciandrini; Pascal Hersen; Jerome Bonnet

    Genetic programs operating in a history-dependent fashion are ubiquitous in nature and govern sophisticated processes such as development and differentiation. The ability to systematically and predictably encode such programs would advance the engineering of synthetic organisms and ecosystems with rich signal processing abilities. Here we implement robust, scalable history-dependent programs by distributing

    更新日期:2020-09-21
  • Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Hisashi Yoshida; Sam-Yong Park; Gyosuke Sakashita; Yuko Nariai; Kanako Kuwasako; Yutaka Muto; Takeshi Urano; Eiji Obayashi

    The accurate exclusion of introns by RNA splicing is critical for the production of mature mRNA. U2AF1 binds specifically to the 3´ splice site, which includes an essential AG dinucleotide. Even a single amino acid mutation of U2AF1 can cause serious disease such as certain cancers or myelodysplastic syndromes. Here, we describe the first crystal structures of wild-type and pathogenic mutant U2AF1

    更新日期:2020-09-21
  • The scaling laws of edge vs. bulk interlayer conduction in mesoscale twisted graphitic interfaces
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Debopriya Dutta; Annabelle Oz; Oded Hod; Elad Koren

    The unusual electronic properties of edges in graphene-based systems originate from the pseudospinorial character of their electronic wavefunctions associated with their non-trivial topological structure. This is manifested by the appearance of pronounced zero-energy electronic states localized at the material zigzag edges that are expected to have a significant contribution to the interlayer transport

    更新日期:2020-09-21
  • The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Alexej Ballhausen; Moritz Jakob Przybilla; Michael Jendrusch; Saskia Haupt; Elisabeth Pfaffendorf; Florian Seidler; Johannes Witt; Alejandro Hernandez Sanchez; Katharina Urban; Markus Draxlbauer; Sonja Krausert; Aysel Ahadova; Martin Simon Kalteis; Pauline L. Pfuderer; Daniel Heid; Damian Stichel; Johannes Gebert; Maria Bonsack; Sarah Schott; Hendrik Bläker; Toni Seppälä; Jukka-Pekka Mecklin; Sanne

    The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency leads to insertion/deletion (indel) mutations at coding microsatellites (cMS) and to neoantigen-inducing translational frameshifts. Here, we develop a tool

    更新日期:2020-09-21
  • Near-atomic resolution structures of interdigitated nucleosome fibres
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Zenita Adhireksan; Deepti Sharma; Phoi Leng Lee; Curt A. Davey

    Chromosome structure at the multi-nucleosomal level has remained ambiguous in spite of its central role in epigenetic regulation and genome dynamics. Recent investigations of chromatin architecture portray diverse modes of interaction within and between nucleosome chains, but how this is realized at the atomic level is unclear. Here we present near-atomic resolution crystal structures of nucleosome

    更新日期:2020-09-21
  • Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Matthew H. Bailey; William U. Meyerson; Lewis Jonathan Dursi; Liang-Bo Wang; Guanlan Dong; Wen-Wei Liang; Amila Weerasinghe; Shantao Li; Sean Kelso; Gordon Saksena; Kyle Ellrott; Michael C. Wendl; David A. Wheeler; Gad Getz; Jared T. Simpson; Mark B. Gerstein; Li Ding

    The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and

    更新日期:2020-09-21
  • Modulated structure determination and ion transport mechanism of oxide-ion conductor CeNbO 4+δ
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Jian Li; Fengjuan Pan; Shipeng Geng; Cong Lin; Lukas Palatinus; Mathieu Allix; Xiaojun Kuang; Jianhua Lin; Junliang Sun

    CeNbO4+δ, a family of oxygen hyperstoichiometry materials with varying oxygen content (CeNbO4, CeNbO4.08, CeNbO4.25, CeNbO4.33) that shows mixed electronic and oxide ionic conduction, has been known for four decades. However, the oxide ionic transport mechanism has remained unclear due to the unknown atomic structures of CeNbO4.08 and CeNbO4.33. Here, we report the complex (3 + 1)D incommensurately

    更新日期:2020-09-21
  • Low-noise GaAs quantum dots for quantum photonics
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Liang Zhai; Matthias C. Löbl; Giang N. Nguyen; Julian Ritzmann; Alisa Javadi; Clemens Spinnler; Andreas D. Wieck; Arne Ludwig; Richard J. Warburton

    Quantum dots are both excellent single-photon sources and hosts for single spins. This combination enables the deterministic generation of Raman-photons—bandwidth-matched to an atomic quantum-memory—and the generation of photon cluster states, a resource in quantum communication and measurement-based quantum computing. GaAs quantum dots in AlGaAs can be matched in frequency to a rubidium-based photon

    更新日期:2020-09-21
  • GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of G s and G q/11
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Dayana Abboud; Adrian F. Daly; Nadine Dupuis; Mohamed Ali Bahri; Asuka Inoue; Andy Chevigné; Fabien Ectors; Alain Plenevaux; Bernard Pirotte; Albert Beckers; Julien Hanson

    Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH-secreting pituitary tumors over-expressing the orphan G-protein coupled receptor, GPR101. The role of GPR101 in GH secretion remains obscure. We studied GPR101 signaling pathways and their effects in HEK293 and rat pituitary GH3 cell lines

    更新日期:2020-09-21
  • Over 90 endangered fish and invertebrates are caught in industrial fisheries
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Leslie A. Roberson; Reg A. Watson; Carissa J. Klein

    Industrial-scale harvest of species at risk of extinction is controversial and usually highly regulated on land and for charismatic marine animals (e.g. whales). In contrast, threatened marine fish species can be legally caught in industrial fisheries. To determine the magnitude and extent of this problem, we analyze global fisheries catch and import data and find reported catch records of 91 globally

    更新日期:2020-09-21
  • Telomere dysfunction activates YAP1 to drive tissue inflammation
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Deepavali Chakravarti; Baoli Hu; Xizeng Mao; Asif Rashid; Jiexi Li; Jun Li; Wen-ting Liao; Elizabeth M. Whitley; Prasenjit Dey; Pingping Hou; Kyle A. LaBella; Andrew Chang; Guocan Wang; Denise J. Spring; Pingna Deng; Di Zhao; Xin Liang; Zhengdao Lan; Yiyun Lin; Sharmistha Sarkar; Christopher Terranova; Yonathan Lissanu Deribe; Sarah E. Blutt; Pablo Okhuysen; Jianhua Zhang; Eduardo Vilar; Ole Haagen

    Germline telomere maintenance defects are associated with an increased incidence of inflammatory diseases in humans, yet whether and how telomere dysfunction causes inflammation are not known. Here, we show that telomere dysfunction drives pATM/c-ABL-mediated activation of the YAP1 transcription factor, up-regulating the major pro-inflammatory factor, pro-IL-18. The colonic microbiome stimulates cytosolic

    更新日期:2020-09-21
  • Ring-opening functionalizations of unstrained cyclic amines enabled by difluorocarbene transfer
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Youyoung Kim; Joon Heo; Dongwook Kim; Sukbok Chang; Sangwon Seo

    Chemical synthesis based on the skeletal variation has been prolifically utilized as an attractive approach for modification of molecular properties. Given the ubiquity of unstrained cyclic amines, the ability to directly alter such motifs would grant an efficient platform to access unique chemical space. Here, we report a highly efficient and practical strategy that enables the selective ring-opening

    更新日期:2020-09-21
  • Visual mate preference evolution during butterfly speciation is linked to neural processing genes
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Matteo Rossi; Alexander E. Hausmann; Timothy J. Thurman; Stephen H. Montgomery; Riccardo Papa; Chris D. Jiggins; W. Owen McMillan; Richard M. Merrill

    Many animal species remain separate not because their individuals fail to produce viable hybrids but because they “choose” not to mate. However, we still know very little of the genetic mechanisms underlying changes in these mate preference behaviours. Heliconius butterflies display bright warning patterns, which they also use to recognize conspecifics. Here, we couple QTL for divergence in visual

    更新日期:2020-09-21
  • Macroecological laws describe variation and diversity in microbial communities
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Jacopo Grilli

    How the coexistence of many species is maintained is a fundamental and unresolved question in ecology. Coexistence is a puzzle because we lack a mechanistic understanding of the variation in species presence and abundance. Whether variation in ecological communities is driven by deterministic or random processes is one of the most controversial issues in ecology. Here, I study the variation of species

    更新日期:2020-09-21
  • Whole genome analysis of water buffalo and global cattle breeds highlights convergent signatures of domestication
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Prasun Dutta; Andrea Talenti; Rachel Young; Siddharth Jayaraman; Rebecca Callaby; Santosh Kumar Jadhav; Velu Dhanikachalam; Mayakannan Manikandan; Bhim B. Biswa; Wai Y. Low; John L. Williams; Elizabeth Cook; Phil Toye; Eileen Wall; Appolinaire Djikeng; Karen Marshall; Alan L. Archibald; Suresh Gokhale; Satish Kumar; David A. Hume; James G. D. Prendergast

    More people globally depend on the water buffalo than any other domesticated species, and as the most closely related domesticated species to cattle they can provide important insights into the shared evolutionary basis of domestication. Here, we sequence the genomes of 79 water buffalo across seven breeds and compare patterns of between breed selective sweeps with those seen for 294 cattle genomes

    更新日期:2020-09-21
  • A predictable conserved DNA base composition signature defines human core DNA replication origins
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Ildem Akerman; Bahar Kasaai; Alina Bazarova; Pau Biak Sang; Isabelle Peiffer; Marie Artufel; Romain Derelle; Gabrielle Smith; Marta Rodriguez-Martinez; Manuela Romano; Sandrina Kinet; Peter Tino; Charles Theillet; Naomi Taylor; Benoit Ballester; Marcel Méchali

    DNA replication initiates from multiple genomic locations called replication origins. In metazoa, DNA sequence elements involved in origin specification remain elusive. Here, we examine pluripotent, primary, differentiating, and immortalized human cells, and demonstrate that a class of origins, termed core origins, is shared by different cell types and host ~80% of all DNA replication initiation events

    更新日期:2020-09-21
  • Regulation of cellular sterol homeostasis by the oxygen responsive noncoding RNA lincNORS
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Xue Wu; Cristina M. Niculite; Mihai Bogdan Preda; Annalisa Rossi; Toma Tebaldi; Elena Butoi; Mattie K. White; Oana M. Tudoran; Daniela N. Petrusca; Amber S. Jannasch; William P. Bone; Xingyue Zong; Fang Fang; Alexandrina Burlacu; Michelle T. Paulsen; Brad A. Hancock; George E. Sandusky; Sumegha Mitra; Melissa L. Fishel; Aaron Buechlein; Cristina Ivan; Spyros Oikonomopoulos; Myriam Gorospe; Amber Mosley;

    We hereby provide the initial portrait of lincNORS, a spliced lincRNA generated by the MIR193BHG locus, entirely distinct from the previously described miR-193b-365a tandem. While inducible by low O2 in a variety of cells and associated with hypoxia in vivo, our studies show that lincNORS is subject to multiple regulatory inputs, including estrogen signals. Biochemically, this lincRNA fine-tunes cellular

    更新日期:2020-09-21
  • Fundamental dissipation due to bound fermions in the zero-temperature limit
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    S. Autti; S. L. Ahlstrom; R. P. Haley; A. Jennings; G. R. Pickett; M. Poole; R. Schanen; A. A. Soldatov; V. Tsepelin; J. Vonka; T. Wilcox; A. J. Woods; D. E. Zmeev

    The ground state of a fermionic condensate is well protected against perturbations in the presence of an isotropic gap. Regions of gap suppression, surfaces and vortex cores which host Andreev-bound states, seemingly lift that strict protection. Here we show that in superfluid 3He the role of bound states is more subtle: when a macroscopic object moves in the superfluid at velocities exceeding the

    更新日期:2020-09-21
  • Oxygen vacancy-driven orbital multichannel Kondo effect in Dirac nodal line metals IrO 2 and RuO 2
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Sheng-Shiuan Yeh; Ta-Kang Su; An-Shao Lien; Farzaneh Zamani; Johann Kroha; Chao-Ching Liao; Stefan Kirchner; Juhn-Jong Lin

    Strong electron correlations have long been recognized as driving the emergence of novel phases of matter. A well recognized example is high-temperature superconductivity which cannot be understood in terms of the standard weak-coupling theory. The exotic properties that accompany the formation of the two-channel Kondo (2CK) effect, including the emergence of an unconventional metallic state in the

    更新日期:2020-09-21
  • Role of higher-order exchange interactions for skyrmion stability
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Souvik Paul; Soumyajyoti Haldar; Stephan von Malottki; Stefan Heinze

    Transition-metal interfaces and multilayers are a promising class of systems to realize nanometer-sized, stable magnetic skyrmions for future spintronic devices. For room temperature applications, it is crucial to understand the interactions which control the stability of isolated skyrmions. Typically, skyrmion properties are explained by the interplay of pair-wise exchange interactions, the Dzyaloshinskii-Moriya

    更新日期:2020-09-21
  • Estimating retention benchmarks for salvage logging to protect biodiversity
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Simon Thorn; Anne Chao; Kostadin B. Georgiev; Jörg Müller; Claus Bässler; John L. Campbell; Jorge Castro; Yan-Han Chen; Chang-Yong Choi; Tyler P. Cobb; Daniel C. Donato; Ewa Durska; Ellen Macdonald; Heike Feldhaar; Joseph B. Fontaine; Paula J. Fornwalt; Raquel María Hernández Hernández; Richard L. Hutto; Matti Koivula; Eun-Jae Lee; David Lindenmayer; Grzegorz Mikusiński; Martin K. Obrist; Michal Perlík;

    Forests are increasingly affected by natural disturbances. Subsequent salvage logging, a widespread management practice conducted predominantly to recover economic capital, produces further disturbance and impacts biodiversity worldwide. Hence, naturally disturbed forests are among the most threatened habitats in the world, with consequences for their associated biodiversity. However, there are no

    更新日期:2020-09-21
  • Single-cell sequencing reveals clonal expansions of pro-inflammatory synovial CD8 T cells expressing tissue-homing receptors in psoriatic arthritis
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Frank Penkava; Martin Del Castillo Velasco-Herrera; Matthew D. Young; Nicole Yager; Lilian N. Nwosu; Arthur G. Pratt; Alicia Lledo Lara; Charlotte Guzzo; Ash Maroof; Lira Mamanova; Suzanne Cole; Mirjana Efremova; Davide Simone; Andrew Filer; Chrysothemis C. Brown; Andrew L. Croxford; John D. Isaacs; Sarah Teichmann; Paul Bowness; Sam Behjati; M. Hussein Al-Mossawi

    Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. Here we use complementary single-cell approaches to study leukocytes from PsA joints. Mass cytometry demonstrates a 3-fold expansion of memory CD8 T cells in the joints of PsA patients compared to peripheral blood. Meanwhile, droplet-based and plate-based

    更新日期:2020-09-21
  • CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Jian-Wei Hao; Juan Wang; Huiling Guo; Yin-Yue Zhao; Hui-Hui Sun; Yi-Fan Li; Xiao-Ying Lai; Ning Zhao; Xu Wang; Changchuan Xie; Lixin Hong; Xi Huang; Hong-Rui Wang; Cheng-Bin Li; Bin Liang; Shuai Chen; Tong-Jin Zhao

    Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipocytes. During the process, binding of FAs to CD36 activates its downstream kinase LYN, which phosphorylates DHHC5, the palmitoyl acyltransferase of CD36, at Tyr91 and inactivates it. CD36 then

    更新日期:2020-09-21
  • India’s potential for integrating solar and on- and offshore wind power into its energy system
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-21
    Tianguang Lu; Peter Sherman; Xinyu Chen; Shi Chen; Xi Lu; Michael McElroy

    This paper considers options for a future Indian power economy in which renewables, wind and solar, could meet 80% of anticipated 2040 power demand supplanting the country’s current reliance on coal. Using a cost optimization model, here we show that renewables could provide a source of power cheaper or at least competitive with what could be supplied using fossil-based alternatives. The ancillary

    更新日期:2020-09-21
  • Semiconductor photocatalysis to engineering deuterated N -alkyl pharmaceuticals enabled by synergistic activation of water and alkanols
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Zhaofei Zhang; Chuntian Qiu; Yangsen Xu; Qing Han; Junwang Tang; Kian Ping Loh; Chenliang Su

    Precisely controlled deuterium labeling at specific sites of N-alkyl drugs is crucial in drug-development as over 50% of the top-selling drugs contain N-alkyl groups, in which it is very challenging to selectively replace protons with deuterium atoms. With the goal of achieving controllable isotope-labeling in N-alkylated amines, we herein rationally design photocatalytic water-splitting to furnish

    更新日期:2020-09-20
  • Controlling in-gap end states by linking nonmagnetic atoms and artificially-constructed spin chains on superconductors
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Lucas Schneider; Sascha Brinker; Manuel Steinbrecher; Jan Hermenau; Thore Posske; Manuel dos Santos Dias; Samir Lounis; Roland Wiesendanger; Jens Wiebe

    Chains of magnetic atoms with either strong spin-orbit coupling or spiral magnetic order which are proximity-coupled to superconducting substrates can host topologically non-trivial Majorana bound states. The experimental signature of these states consists of spectral weight at the Fermi energy which is spatially localized near the ends of the chain. However, topologically trivial Yu-Shiba-Rusinov

    更新日期:2020-09-20
  • Electron hydrodynamics in anisotropic materials
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-18
    Georgios Varnavides; Adam S. Jermyn; Polina Anikeeva; Claudia Felser; Prineha Narang

    Rotational invariance strongly constrains the viscosity tensor of classical fluids. When this symmetry is broken in anisotropic materials a wide array of novel phenomena become possible. We explore electron fluid behaviors arising from the most general viscosity tensors in two and three dimensions, constrained only thermodynamics and crystal symmetries. We find nontrivial behaviors in both two- and

    更新日期:2020-09-20