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  • Author Correction: PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Min-Sik Lee; Man-Hyung Jeong; Hyun-Woo Lee; Hyun-Ji Han; Aram Ko; Stephen M. Hewitt; Jae-Hoon Kim; Kyung-Hee Chun; Joon-Yong Chung; Cheolju Lee; Hanbyoul Cho; Jaewhan Song

    A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20178-0

    更新日期:2020-12-01
  • Low threshold lasing emissions from a single upconversion nanocrystal
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Yunfei Shang; Jiajia Zhou; Yangjian Cai; Fan Wang; Angel Fernandez-Bravo; Chunhui Yang; Lei Jiang; Dayong Jin

    Cross-relaxation among neighboring emitters normally causes self-quenching and limits the brightness of luminescence. However, in nanomaterials, cross-relaxation could be well-controlled and employed for increasing the luminescence efficiency at specific wavelengths. Here we report that cross-relaxation can modulate both the brightness of single upconversion nanoparticles and the threshold to reach

    更新日期:2020-12-01
  • Winnie Byanyima answers questions about the impact of the COVID-19 pandemic on the UNAIDS’ Fast Track targets for 2020
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01

    Winnie Byanyima is the Executive Director of UNAIDS and leads the United Nations’ efforts to end the AIDS epidemic by 2030. She is also a longstanding champion of social justice and gender equality having led Uganda’s first parliamentary women’s caucus where she championed gender equality provisions during her 11 years as an elected member of the Ugandan parliament. To mark World AIDS Day 2020, Nature

    更新日期:2020-12-01
  • Non-invasive focusing and imaging in scattering media with a fluorescence-based transmission matrix
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Antoine Boniface; Jonathan Dong; Sylvain Gigan

    In biological microscopy, light scattering represents the main limitation to image at depth. Recently, a set of wavefront shaping techniques has been developed in order to manipulate coherent light in strongly disordered materials. The Transmission Matrix approach has shown its capability to inverse the effect of scattering and efficiently focus light. In practice, the matrix is usually measured using

    更新日期:2020-12-01
  • The liverwort oil body is formed by redirection of the secretory pathway
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Takehiko Kanazawa; Hatsune Morinaka; Kazuo Ebine; Takashi L. Shimada; Sakiko Ishida; Naoki Minamino; Katsushi Yamaguchi; Shuji Shigenobu; Takayuki Kohchi; Akihiko Nakano; Takashi Ueda

    Eukaryotic cells acquired novel organelles during evolution through mechanisms that remain largely obscure. The existence of the unique oil body compartment is a synapomorphy of liverworts that represents lineage-specific acquisition of this organelle during evolution, although its origin, biogenesis, and physiological function are yet unknown. We find that two paralogous syntaxin-1 homologs in the

    更新日期:2020-12-01
  • Towards a unified open access dataset of molecular interactions
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Pablo Porras; Elisabet Barrera; Alan Bridge; Noemi del-Toro; Gianni Cesareni; Margaret Duesbury; Henning Hermjakob; Marta Iannuccelli; Igor Jurisica; Max Kotlyar; Luana Licata; Ruth C. Lovering; David J. Lynn; Birgit Meldal; Bindu Nanduri; Kalpana Paneerselvam; Simona Panni; Chiara Pastrello; Matteo Pellegrini; Livia Perfetto; Negin Rahimzadeh; Prashansa Ratan; Sylvie Ricard-Blum; Lukasz Salwinski;

    The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging

    更新日期:2020-12-01
  • Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Jan Zrimec; Christoph S. Börlin; Filip Buric; Azam Sheikh Muhammad; Rhongzen Chen; Verena Siewers; Vilhelm Verendel; Jens Nielsen; Mats Töpel; Aleksej Zelezniak

    Understanding the genetic regulatory code governing gene expression is an important challenge in molecular biology. However, how individual coding and non-coding regions of the gene regulatory structure interact and contribute to mRNA expression levels remains unclear. Here we apply deep learning on over 20,000 mRNA datasets to examine the genetic regulatory code controlling mRNA abundance in 7 model

    更新日期:2020-12-01
  • Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    F. T. Sparks; Z. Liao; W. Li; A. Grosmark; I. Soltesz; A. Losonczy

    Temporal lobe epilepsy (TLE) is characterized by recurrent seizures driven by synchronous neuronal activity. The reorganization of the dentate gyrus (DG) in TLE may create pathological conduction pathways for synchronous discharges in the temporal lobe, though critical microcircuit-level detail is missing from this pathophysiological intuition. In particular, the relative contribution of adult-born

    更新日期:2020-12-01
  • Glycoproteomics-based signatures for tumor subtyping and clinical outcome prediction of high-grade serous ovarian cancer
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Jianbo Pan; Yingwei Hu; Shisheng Sun; Lijun Chen; Michael Schnaubelt; David Clark; Minghui Ao; Zhen Zhang; Daniel Chan; Jiang Qian; Hui Zhang

    Inter-tumor heterogeneity is a result of genomic, transcriptional, translational, and post-translational molecular features. To investigate the roles of protein glycosylation in the heterogeneity of high-grade serous ovarian carcinoma (HGSC), we perform mass spectrometry-based glycoproteomic characterization of 119 TCGA HGSC tissues. Cluster analysis of intact glycoproteomic profiles delineates 3 major

    更新日期:2020-12-01
  • Carbonate-silicate cycle predictions of Earth-like planetary climates and testing the habitable zone concept
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Owen R. Lehmer; David C. Catling; Joshua Krissansen-Totton

    In the conventional habitable zone (HZ) concept, a CO2-H2O greenhouse maintains surface liquid water. Through the water-mediated carbonate-silicate weathering cycle, atmospheric CO2 partial pressure (pCO2) responds to changes in surface temperature, stabilizing the climate over geologic timescales. We show that this weathering feedback ought to produce a log-linear relationship between pCO2 and incident

    更新日期:2020-12-01
  • The economic costs of planting, preserving, and managing the world’s forests to mitigate climate change
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    K. G. Austin; J. S. Baker; B. L. Sohngen; C. M. Wade; A. Daigneault; S. B. Ohrel; S. Ragnauth; A. Bean

    Forests are critical for stabilizing our climate, but costs of mitigation over space, time, and stakeholder group remain uncertain. Using the Global Timber Model, we project mitigation potential and costs for four abatement activities across 16 regions for carbon price scenarios of $5–$100/tCO2. We project 0.6–6.0 GtCO2 yr−1 in global mitigation by 2055 at costs of 2–393 billion USD yr−1, with avoided

    更新日期:2020-12-01
  • Ultrasensitive antibody-aptamer plasmonic biosensor for malaria biomarker detection in whole blood
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Antonio Minopoli; Bartolomeo Della Ventura; Bohdan Lenyk; Francesco Gentile; Julian A. Tanner; Andreas Offenhäusser; Dirk Mayer; Raffaele Velotta

    Development of plasmonic biosensors combining reliability and ease of use is still a challenge. Gold nanoparticle arrays made by block copolymer micelle nanolithography (BCMN) stand out for their scalability, cost-effectiveness and tunable plasmonic properties, making them ideal substrates for fluorescence enhancement. Here, we describe a plasmon-enhanced fluorescence immunosensor for the specific

    更新日期:2020-12-01
  • Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Heli Julkunen; Anna Cichonska; Prson Gautam; Sandor Szedmak; Jane Douat; Tapio Pahikkala; Tero Aittokallio; Juho Rousu

    We present comboFM, a machine learning framework for predicting the responses of drug combinations in pre-clinical studies, such as those based on cell lines or patient-derived cells. comboFM models the cell context-specific drug interactions through higher-order tensors, and efficiently learns latent factors of the tensor using powerful factorization machines. The approach enables comboFM to leverage

    更新日期:2020-12-01
  • Conformational maps of human 20S proteasomes reveal PA28- and immuno-dependent inter-ring crosstalks
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Jean Lesne; Marie Locard-Paulet; Julien Parra; Dušan Zivković; Thomas Menneteau; Marie-Pierre Bousquet; Odile Burlet-Schiltz; Julien Marcoux

    Hydrogen-Deuterium eXchange coupled to Mass Spectrometry (HDX-MS) is now common practice in structural biology. However, it is most of the time applied to rather small oligomeric complexes. Here, we report on the use of HDX-MS to investigate conformational differences between the human standard 20S (std20S) and immuno 20S (i20s) proteasomes alone or in complex with PA28αβ or PA28γ activators. Their

    更新日期:2020-12-01
  • Optical-field driven charge-transfer modulations near composite nanostructures
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Kwang Jin Lee; Elke Beyreuther; Sohail A. Jalil; Sang Jun Kim; Lukas M. Eng; Chunlei Guo; Pascal André

    Optical activation of material properties illustrates the potentials held by tuning light-matter interactions with impacts ranging from basic science to technological applications. Here, we demonstrate for the first time that composite nanostructures providing nonlocal environments can be engineered to optically trigger photoinduced charge-transfer-dynamic modulations in the solid state. The nanostructures

    更新日期:2020-12-01
  • Quantitative modeling predicts mechanistic links between pre-treatment microbiome composition and metronidazole efficacy in bacterial vaginosis
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Christina Y. Lee; Ryan K. Cheu; Melissa M. Lemke; Andrew T. Gustin; Michael T. France; Benjamin Hampel; Andrea R. Thurman; Gustavo F. Doncel; Jacques Ravel; Nichole R. Klatt; Kelly B. Arnold

    Bacterial vaginosis is a condition associated with adverse reproductive outcomes and characterized by a shift from a Lactobacillus-dominant vaginal microbiota to a polymicrobial microbiota, consistently colonized by strains of Gardnerella vaginalis. Metronidazole is the first-line treatment; however, treatment failure and recurrence rates remain high. To understand complex interactions between Gardnerella

    更新日期:2020-12-01
  • Non-invasive single-cell morphometry in living bacterial biofilms
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Mingxing Zhang; Ji Zhang; Yibo Wang; Jie Wang; Alecia M. Achimovich; Scott T. Acton; Andreas Gahlmann

    Fluorescence microscopy enables spatial and temporal measurements of live cells and cellular communities. However, this potential has not yet been fully realized for investigations of individual cell behaviors and phenotypic changes in dense, three-dimensional (3D) bacterial biofilms. Accurate cell detection and cellular shape measurement in densely packed biofilms are challenging because of the limited

    更新日期:2020-12-01
  • Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Antonios Psarras; Adewonuola Alase; Agne Antanaviciute; Ian M. Carr; Md Yuzaiful Md Yusof; Miriam Wittmann; Paul Emery; George C. Tsokos; Edward M. Vital

    Autoimmune connective tissue diseases arise in a stepwise fashion from asymptomatic preclinical autoimmunity. Type I interferons have a crucial role in the progression to established autoimmune diseases. The cellular source and regulation in disease initiation of these cytokines is not clear, but plasmacytoid dendritic cells have been thought to contribute to excessive type I interferon production

    更新日期:2020-12-01
  • Gap junctions amplify spatial variations in cell volume in proliferating tumor spheroids
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Eoin McEvoy; Yu Long Han; Ming Guo; Vivek B. Shenoy

    Sustained proliferation is a significant driver of cancer progression. Cell-cycle advancement is coupled with cell size, but it remains unclear how multiple cells interact to control their volume in 3D clusters. In this study, we propose a mechano-osmotic model to investigate the evolution of volume dynamics within multicellular systems. Volume control depends on an interplay between multiple cellular

    更新日期:2020-12-01
  • Natural optical activity as the origin of the large chiroptical properties in π-conjugated polymer thin films
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Jessica Wade; James N. Hilfiker; Jochen R. Brandt; Letizia Liirò-Peluso; Li Wan; Xingyuan Shi; Francesco Salerno; Seán T. J. Ryan; Stefan Schöche; Oriol Arteaga; Tamás Jávorfi; Giuliano Siligardi; Cheng Wang; David B. Amabilino; Peter H. Beton; Alasdair J. Campbell; Matthew J. Fuchter

    Polymer thin films that emit and absorb circularly polarised light have been demonstrated with the promise of achieving important technological advances; from efficient, high-performance displays, to 3D imaging and all-organic spintronic devices. However, the origin of the large chiroptical effects in such films has, until now, remained elusive. We investigate the emergence of such phenomena in achiral

    更新日期:2020-12-01
  • Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Enrico Girardi; Gennaro Agrimi; Ulrich Goldmann; Giuseppe Fiume; Sabrina Lindinger; Vitaly Sedlyarov; Ismet Srndic; Bettina Gürtl; Benedikt Agerer; Felix Kartnig; Pasquale Scarcia; Maria Antonietta Di Noia; Eva Liñeiro; Manuele Rebsamen; Tabea Wiedmer; Andreas Bergthaler; Luigi Palmieri; Giulio Superti-Furga

    About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be an efficient way to obtain functional information allowing their deorphanization. Here we describe a network

    更新日期:2020-12-01
  • A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Viorel Simion; Haoyang Zhou; Stefan Haemmig; Jacob B. Pierce; Shanelle Mendes; Yevgenia Tesmenitsky; Daniel Pérez-Cremades; James F. Lee; Alex F. Chen; Nicoletta Ronda; Bianca Papotti; Jarrod A. Marto; Mark W. Feinberg

    Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes including atherosclerosis. Using RNA-seq profiling of the intima of lesions, here we identify a macrophage-specific lncRNA MAARS (Macrophage-Associated Atherosclerosis lncRNA Sequence). Aortic intima expression of MAARS increases by 270-fold with atherosclerotic progression and decreases with regression by 60%. MAARS

    更新日期:2020-12-01
  • Cohesin depleted cells rebuild functional nuclear compartments after endomitosis
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Marion Cremer; Katharina Brandstetter; Andreas Maiser; Suhas S. P. Rao; Volker J. Schmid; Miguel Guirao-Ortiz; Namita Mitra; Stefania Mamberti; Kyle N. Klein; David M. Gilbert; Heinrich Leonhardt; M. Cristina Cardoso; Erez Lieberman Aiden; Hartmann Harz; Thomas Cremer

    Cohesin plays an essential role in chromatin loop extrusion, but its impact on a compartmentalized nuclear architecture, linked to nuclear functions, is less well understood. Using live-cell and super-resolved 3D microscopy, here we find that cohesin depletion in a human colon cancer derived cell line results in endomitosis and a single multilobulated nucleus with chromosome territories pervaded by

    更新日期:2020-12-01
  • Efficient spin excitation via ultrafast damping-like torques in antiferromagnets
    Nat. Commun. (IF 12.121) Pub Date : 2020-12-01
    Christian Tzschaschel; Takuya Satoh; Manfred Fiebig

    Damping effects form the core of many emerging concepts for high-speed spintronic applications. Important characteristics such as device switching times and magnetic domain-wall velocities depend critically on the damping rate. While the implications of spin damping for relaxation processes are intensively studied, damping effects during impulsive spin excitations are assumed to be negligible because

    更新日期:2020-12-01
  • Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Jared S. Mackenzie; Dirk A. Lamprecht; Rukaya Asmal; John H. Adamson; Khushboo Borah; Dany J. V. Beste; Bei Shi Lee; Kevin Pethe; Simon Rousseau; Inna Krieger; James C. Sacchettini; Joel N. Glasgow; Adrie J. C. Steyn

    The approval of bedaquiline (BDQ) for the treatment of tuberculosis has generated substantial interest in inhibiting energy metabolism as a therapeutic paradigm. However, it is not known precisely how BDQ triggers cell death in Mycobacterium tuberculosis (Mtb). Using 13C isotopomer analysis, we show that BDQ-treated Mtb redirects central carbon metabolism to induce a metabolically vulnerable state

    更新日期:2020-12-01
  • Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Di Wu; Ying Jin; Tatiana M. Shapiro; Abhishek Hinduja; Peter W. Baas; Veronica J. Tom

    After a dorsal root crush injury, centrally-projecting sensory axons fail to regenerate across the dorsal root entry zone (DREZ) to extend into the spinal cord. We find that chemogenetic activation of adult dorsal root ganglion (DRG) neurons improves axon growth on an in vitro model of the inhibitory environment after injury. Moreover, repeated bouts of daily chemogenetic activation of adult DRG neurons

    更新日期:2020-12-01
  • Differential guest location by host dynamics enhances propylene/propane separation in a metal-organic framework
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Dmytro Antypov; Aleksander Shkurenko; Prashant M. Bhatt; Youssef Belmabkhout; Karim Adil; Amandine Cadiau; Mikhail Suyetin; Mohamed Eddaoudi; Matthew J. Rosseinsky; Matthew S. Dyer

    Energy-efficient approaches to propylene/propane separation such as molecular sieving are of considerable importance for the petrochemical industry. The metal organic framework NbOFFIVE-1-Ni adsorbs propylene but not propane at room temperature and atmospheric pressure, whereas the isostructural SIFSIX-3-Ni does not exclude propane under the same conditions. The static dimensions of the pore openings

    更新日期:2020-12-01
  • Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Kristen E. Clements; Emily M. Schleicher; Tanay Thakar; Anastasia Hale; Ashna Dhoonmoon; Nathanial J. Tolman; Anchal Sharma; Xinwen Liang; Yuka Imamura Kawasawa; Claudia M. Nicolae; Hong-Gang Wang; Subhajyoti De; George-Lucian Moldovan

    Inhibitors of poly-ADP-ribose polymerase 1 (PARPi) are highly effective in killing cells deficient in homologous recombination (HR); thus, PARPi have been clinically utilized to successfully treat BRCA2-mutant tumors. However, positive response to PARPi is not universal, even among patients with HR-deficiency. Here, we present the results of genome-wide CRISPR knockout and activation screens which

    更新日期:2020-12-01
  • Enhanced dispersion stability of gold nanoparticles by the physisorption of cyclic poly(ethylene glycol)
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Yubo Wang; Jose Enrico Q. Quinsaat; Tomoko Ono; Masatoshi Maeki; Manabu Tokeshi; Takuya Isono; Kenji Tajima; Toshifumi Satoh; Shin-ichiro Sato; Yutaka Miura; Takuya Yamamoto

    Nano-sized metal particles are attracting much interest in industrial and biomedical applications due to the recent progress and development of nanotechnology, and the surface-modifications by appropriate polymers are key techniques to stably express their characteristics. Herein, we applied cyclic poly(ethylene glycol) (c-PEG), having no chemical inhomogeneity, to provide a polymer topology-dependent

    更新日期:2020-12-01
  • MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar Hypoplasia
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Ekin Ucuncu; Karthyayani Rajamani; Miranda S. C. Wilson; Daniel Medina-Cano; Nami Altin; Pierre David; Giulia Barcia; Nathalie Lefort; Céline Banal; Marie-Thérèse Vasilache-Dangles; Gaële Pitelet; Elsa Lorino; Nathalie Rabasse; Eric Bieth; Maha S. Zaki; Meral Topcu; Fatma Mujgan Sonmez; Damir Musaev; Valentina Stanley; Christine Bole-Feysot; Patrick Nitschké; Arnold Munnich; Nadia Bahi-Buisson; Catherine

    Inositol polyphosphates are vital metabolic and secondary messengers, involved in diverse cellular functions. Therefore, tight regulation of inositol polyphosphate metabolism is essential for proper cell physiology. Here, we describe an early-onset neurodegenerative syndrome caused by loss-of-function mutations in the multiple inositol-polyphosphate phosphatase 1 gene (MINPP1). Patients are found to

    更新日期:2020-12-01
  • BETs inhibition attenuates oxidative stress and preserves muscle integrity in Duchenne muscular dystrophy
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Marco Segatto; Roberta Szokoll; Raffaella Fittipaldi; Cinzia Bottino; Lorenzo Nevi; Kamel Mamchaoui; Panagis Filippakopoulos; Giuseppina Caretti

    Duchenne muscular dystrophy (DMD) affects 1 in 3500 live male births. To date, there is no effective cure for DMD, and the identification of novel molecular targets involved in disease progression is important to design more effective treatments and therapies to alleviate DMD symptoms. Here, we show that protein levels of the Bromodomain and extra-terminal domain (BET) protein BRD4 are significantly

    更新日期:2020-12-01
  • CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Man Zhang; Wei Yang; Peng Wang; Yu Deng; Yu-Ting Dong; Fang-Fang Liu; Rui Huang; Peng Zhang; Ya-Qi Duan; Xin-Dong Liu; Dandan Lin; Qian Chu; Bo Zhong

    The efficacy of checkpoint immunotherapy to non-small cell lung cancer (NSCLC) largely depends on the tumor microenvironment (TME). Here, we demonstrate that CCL7 facilitates anti-PD-1 therapy for the KrasLSL−G12D/+Tp53fl/fl (KP) and the KrasLSL−G12D/+Lkb1fl/fl (KL) NSCLC mouse models by recruiting conventional DC 1 (cDC1) into the TME to promote T cell expansion. CCL7 exhibits high expression in NSCLC

    更新日期:2020-12-01
  • Quantitative estimates of average geomagnetic axial dipole dominance in deep geological time
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Andrew J. Biggin; Richard K. Bono; Domenico G. Meduri; Courtney J. Sprain; Christopher J. Davies; Richard Holme; Pavel V. Doubrovine

    A defining characteristic of the recent geomagnetic field is its dominant axial dipole which provides its navigational utility and dictates the shape of the magnetosphere. Going back through time, much less is known about the degree of axial dipole dominance. Here we use a substantial and diverse set of 3D numerical dynamo simulations and recent observation-based field models to derive a power law

    更新日期:2020-12-01
  • Bismuth atom tailoring of indium oxide surface frustrated Lewis pairs boosts heterogeneous CO 2 photocatalytic hydrogenation
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Tingjiang Yan; Na Li; Linlin Wang; Weiguang Ran; Paul N. Duchesne; Lili Wan; Nhat Truong Nguyen; Lu Wang; Meikun Xia; Geoffrey A. Ozin

    The surface frustrated Lewis pairs (SFLPs) on defect-laden metal oxides provide catalytic sites to activate H2 and CO2 molecules and enable efficient gas-phase CO2 photocatalysis. Lattice engineering of metal oxides provides a useful strategy to tailor the reactivity of SFLPs. Herein, a one-step solvothermal synthesis is developed that enables isomorphic replacement of Lewis acidic site In3+ ions in

    更新日期:2020-12-01
  • Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Pierre-Alexandre Just; Sara Charawi; Raphaël G. P. Denis; Mathilde Savall; Massiré Traore; Marc Foretz; Sultan Bastu; Salimata Magassa; Nadia Senni; Pierre Sohier; Maud Wursmer; Mireille Vasseur-Cognet; Alain Schmitt; Morgane Le Gall; Marjorie Leduc; François Guillonneau; Jean-Pascal De Bandt; Patrick Mayeux; Béatrice Romagnolo; Serge Luquet; Pascale Bossard; Christine Perret

    Excessive glucose production by the liver is a key factor in the hyperglycemia observed in type 2 diabetes mellitus (T2DM). Here, we highlight a novel role of liver kinase B1 (Lkb1) in this regulation. We show that mice with a hepatocyte-specific deletion of Lkb1 have higher levels of hepatic amino acid catabolism, driving gluconeogenesis. This effect is observed during both fasting and the postprandial

    更新日期:2020-12-01
  • High pressure synthesis of phosphine from the elements and the discovery of the missing (PH 3 ) 2 H 2 tile
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Matteo Ceppatelli; Demetrio Scelta; Manuel Serrano-Ruiz; Kamil Dziubek; Gaston Garbarino; Jeroen Jacobs; Mohamed Mezouar; Roberto Bini; Maurizio Peruzzini

    High pressure reactivity of phosphorus and hydrogen is relevant to fundamental chemistry, energy conversion and storage, and materials science. Here we report the synthesis of (PH3)2H2, a crystalline van der Waals (vdW) compound (I4cm) made of PH3 and H2 molecules, in a Diamond Anvil Cell by direct catalyst-free high pressure (1.2 GPa) and high temperature (T ≲ 1000 K) chemical reaction of black phosphorus

    更新日期:2020-12-01
  • Diverse crystal size effects in covalent organic frameworks
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Tianqiong Ma; Lei Wei; Lin Liang; Shawn Yin; Le Xu; Jing Niu; Huadong Xue; Xiaoge Wang; Junliang Sun; Yue-Biao Zhang; Wei Wang

    Crystal size effect is of vital importance in materials science by exerting significant influence on various properties of materials and furthermore their functions. Crystal size effect of covalent organic frameworks (COFs) has never been reported because their controllable synthesis is difficult, despite their promising properties have been exhibited in many aspects. Here, we report the diverse crystal

    更新日期:2020-12-01
  • Asymmetric polyamide nanofilms with highly ordered nanovoids for water purification
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Bingbing Yuan; Shengchao Zhao; Ping Hu; Jiabao Cui; Q. Jason Niu

    Tailor-made structure and morphology are critical to the highly permeable and selective polyamide membranes used for water purification. Here we report an asymmetric polyamide nanofilm having a two-layer structure, in which the lower is a spherical polyamide dendrimer porous layer, and the upper is a polyamide dense layer with highly ordered nanovoids structure. The dendrimer porous layer was covalently

    更新日期:2020-12-01
  • Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Fatai S. Oladunni; Jun-Gyu Park; Paula A. Pino; Olga Gonzalez; Anwari Akhter; Anna Allué-Guardia; Angélica Olmo-Fontánez; Shalini Gautam; Andreu Garcia-Vilanova; Chengjin Ye; Kevin Chiem; Colwyn Headley; Varun Dwivedi; Laura M. Parodi; Kendra J. Alfson; Hilary M. Staples; Alyssa Schami; Juan I. Garcia; Alison Whigham; Roy Neal Platt; Michal Gazi; Jesse Martinez; Colin Chuba; Stephanie Earley; Oscar

    Vaccine and antiviral development against SARS-CoV-2 infection or COVID-19 disease would benefit from validated small animal models. Here, we show that transgenic mice expressing human angiotensin-converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18 hACE2) represent a susceptible rodent model. K18 hACE2 transgenic mice succumbed to SARS-CoV-2 infection by day 6, with virus detected

    更新日期:2020-12-01
  • Organo–organic and organo–mineral interfaces in soil at the nanometer scale
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Angela R. Possinger; Michael J. Zachman; Akio Enders; Barnaby D. A. Levin; David A. Muller; Lena F. Kourkoutis; Johannes Lehmann

    The capacity of soil as a carbon (C) sink is mediated by interactions between organic matter and mineral phases. However, previously proposed layered accumulation of organic matter within aggregate organo–mineral microstructures has not yet been confirmed by direct visualization at the necessary nanometer-scale spatial resolution. Here, we identify disordered micrometer-size organic phases rather than

    更新日期:2020-12-01
  • An investigation of irreproducibility in maximum likelihood phylogenetic inference
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Xing-Xing Shen; Yuanning Li; Chris Todd Hittinger; Xue-xin Chen; Antonis Rokas

    Phylogenetic trees are essential for studying biology, but their reproducibility under identical parameter settings remains unexplored. Here, we find that 3515 (18.11%) IQ-TREE-inferred and 1813 (9.34%) RAxML-NG-inferred maximum likelihood (ML) gene trees are topologically irreproducible when executing two replicates (Run1 and Run2) for each of 19,414 gene alignments in 15 animal, plant, and fungal

    更新日期:2020-12-01
  • Valley interference and spin exchange at the atomic scale in silicon
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    B. Voisin; J. Bocquel; A. Tankasala; M. Usman; J. Salfi; R. Rahman; M. Y. Simmons; L. C. L. Hollenberg; S. Rogge

    Tunneling is a fundamental quantum process with no classical equivalent, which can compete with Coulomb interactions to give rise to complex phenomena. Phosphorus dopants in silicon can be placed with atomic precision to address the different regimes arising from this competition. However, they exploit wavefunctions relying on crystal band symmetries, which tunneling interactions are inherently sensitive

    更新日期:2020-12-01
  • Probing the ionic defect landscape in halide perovskite solar cells
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Sebastian Reichert; Qingzhi An; Young-Won Woo; Aron Walsh; Yana Vaynzof; Carsten Deibel

    Point defects in metal halide perovskites play a critical role in determining their properties and optoelectronic performance; however, many open questions remain unanswered. In this work, we apply impedance spectroscopy and deep-level transient spectroscopy to characterize the ionic defect landscape in methylammonium lead triiodide (MAPbI3) perovskites in which defects were purposely introduced by

    更新日期:2020-12-01
  • How to speed up ion transport in nanopores
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Konrad Breitsprecher; Mathijs Janssen; Pattarachai Srimuk; B. Layla Mehdi; Volker Presser; Christian Holm; Svyatoslav Kondrat

    Electrolyte-filled subnanometre pores exhibit exciting physics and play an increasingly important role in science and technology. In supercapacitors, for instance, ultranarrow pores provide excellent capacitive characteristics. However, ions experience difficulties in entering and leaving such pores, which slows down charging and discharging processes. In an earlier work we showed for a simple model

    更新日期:2020-12-01
  • Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Matthew H. Bailey; William U. Meyerson; Lewis Jonathan Dursi; Liang-Bo Wang; Guanlan Dong; Wen-Wei Liang; Amila Weerasinghe; Shantao Li; Yize Li; Sean Kelso; Gordon Saksena; Kyle Ellrott; Michael C. Wendl; David A. Wheeler; Gad Getz; Jared T. Simpson; Mark B. Gerstein; Li Ding

    Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20128-w

    更新日期:2020-12-01
  • Integration of daytime radiative cooling and solar heating for year-round energy saving in buildings
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Xiuqiang Li; Bowen Sun; Chenxi Sui; Ankita Nandi; Haoming Fang; Yucan Peng; Gang Tan; Po-Chun Hsu

    The heating and cooling energy consumption of buildings accounts for about 15% of national total energy consumption in the United States. In response to this challenge, many promising technologies with minimum carbon footprint have been proposed. However, most of the approaches are static and monofunctional, which can only reduce building energy consumption in certain conditions and climate zones.

    更新日期:2020-12-01
  • muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Helena L. Crowell; Charlotte Soneson; Pierre-Luc Germain; Daniela Calini; Ludovic Collin; Catarina Raposo; Dheeraj Malhotra; Mark D. Robinson

    Single-cell RNA sequencing (scRNA-seq) has become an empowering technology to profile the transcriptomes of individual cells on a large scale. Early analyses of differential expression have aimed at identifying differences between subpopulations to identify subpopulation markers. More generally, such methods compare expression levels across sets of cells, thus leading to cross-condition analyses. Given

    更新日期:2020-12-01
  • Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Flavia Chiuppesi; Marcela d’Alincourt Salazar; Heidi Contreras; Vu H. Nguyen; Joy Martinez; Yoonsuh Park; Jenny Nguyen; Mindy Kha; Angelina Iniguez; Qiao Zhou; Teodora Kaltcheva; Roman Levytskyy; Nancy D. Ebelt; Tae Hyuk Kang; Xiwei Wu; Thomas F. Rogers; Edwin R. Manuel; Yuriy Shostak; Don J. Diamond; Felix Wussow

    Modified Vaccinia Ankara (MVA) is a highly attenuated poxvirus vector that is widely used to develop vaccines for infectious diseases and cancer. We demonstrate the construction of a vaccine platform based on a unique three-plasmid system to efficiently generate recombinant MVA vectors from chemically synthesized DNA. In response to the ongoing global pandemic caused by SARS coronavirus-2 (SARS-CoV-2)

    更新日期:2020-12-01
  • Direct binding of TFEα opens DNA binding cleft of RNA polymerase
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Sung-Hoon Jun; Jaekyung Hyun; Jeong Seok Cha; Hoyoung Kim; Michael S. Bartlett; Hyun-Soo Cho; Katsuhiko S. Murakami

    Opening of the DNA binding cleft of cellular RNA polymerase (RNAP) is necessary for transcription initiation but the underlying molecular mechanism is not known. Here, we report on the cryo-electron microscopy structures of the RNAP, RNAP-TFEα binary, and RNAP-TFEα-promoter DNA ternary complexes from archaea, Thermococcus kodakarensis (Tko). The structures reveal that TFEα bridges the RNAP clamp and

    更新日期:2020-12-01
  • Identity-by-descent detection across 487,409 British samples reveals fine scale population structure and ultra-rare variant associations
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Juba Nait Saada; Georgios Kalantzis; Derek Shyr; Fergus Cooper; Martin Robinson; Alexander Gusev; Pier Francesco Palamara

    Detection of Identical-By-Descent (IBD) segments provides a fundamental measure of genetic relatedness and plays a key role in a wide range of analyses. We develop FastSMC, an IBD detection algorithm that combines a fast heuristic search with accurate coalescent-based likelihood calculations. FastSMC enables biobank-scale detection and dating of IBD segments within several thousands of years in the

    更新日期:2020-12-01
  • Bayesian learning of chemisorption for bridging the complexity of electronic descriptors
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Siwen Wang; Hemanth Somarajan Pillai; Hongliang Xin

    Building upon the d-band reactivity theory in surface chemistry and catalysis, we develop a Bayesian learning approach to probing chemisorption processes at atomically tailored metal sites. With representative species, e.g., *O and *OH, Bayesian models trained with ab initio adsorption properties of transition metals predict site reactivity at a diverse range of intermetallics and near-surface alloys

    更新日期:2020-12-01
  • An original infection model identifies host lipoprotein import as a route for blood-brain barrier crossing
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Billel Benmimoun; Florentia Papastefanaki; Bruno Périchon; Katerina Segklia; Nicolas Roby; Vivi Miriagou; Christine Schmitt; Shaynoor Dramsi; Rebecca Matsas; Pauline Spéder

    Pathogens able to cross the blood-brain barrier (BBB) induce long-term neurological sequelae and death. Understanding how neurotropic pathogens bypass this strong physiological barrier is a prerequisite to devise therapeutic strategies. Here we propose an innovative model of infection in the developing Drosophila brain, combining whole brain explants with in vivo systemic infection. We find that several

    更新日期:2020-12-01
  • A new view on the origin of zero-bias anomalies of Co atoms atop noble metal surfaces
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Juba Bouaziz; Filipe Souza Mendes Guimarães; Samir Lounis

    Many-body phenomena are paramount in physics. In condensed matter, their hallmark is considerable on a wide range of material characteristics spanning electronic, magnetic, thermodynamic and transport properties. They potentially imprint non-trivial signatures in spectroscopic measurements, such as those assigned to Kondo, excitonic and polaronic features, whose emergence depends on the involved degrees

    更新日期:2020-12-01
  • Edge-oriented and steerable hyperbolic polaritons in anisotropic van der Waals nanocavities
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Zhigao Dai; Guangwei Hu; Guangyuan Si; Qingdong Ou; Qing Zhang; Sivacarendran Balendhran; Fahmida Rahman; Bao Yue Zhang; Jian Zhen Ou; Guogang Li; Andrea Alù; Cheng-Wei Qiu; Qiaoliang Bao

    Highly confined and low-loss polaritons are known to propagate isotropically over graphene and hexagonal boron nitride in the plane, leaving limited degrees of freedom in manipulating light at the nanoscale. The emerging family of biaxial van der Waals materials, such as α-MoO3 and V2O5, support exotic polariton propagation, as their auxiliary optical axis is in the plane. Here, exploiting this strong

    更新日期:2020-12-01
  • Spatially expandable fiber-based probes as a multifunctional deep brain interface
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Shan Jiang; Dipan C. Patel; Jongwoon Kim; Shuo Yang; William A. Mills; Yujing Zhang; Kaiwen Wang; Ziang Feng; Sujith Vijayan; Wenjun Cai; Anbo Wang; Yuanyuan Guo; Ian F. Kimbrough; Harald Sontheimer; Xiaoting Jia

    Understanding the cytoarchitecture and wiring of the brain requires improved methods to record and stimulate large groups of neurons with cellular specificity. This requires miniaturized neural interfaces that integrate into brain tissue without altering its properties. Existing neural interface technologies have been shown to provide high-resolution electrophysiological recording with high signal-to-noise

    更新日期:2020-12-01
  • Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    C. Madore; Q. Leyrolle; L. Morel; M. Rossitto; A. D. Greenhalgh; J. C. Delpech; M. Martinat; C. Bosch-Bouju; J. Bourel; B. Rani; C. Lacabanne; A. Thomazeau; K. E. Hopperton; S. Beccari; A. Sere; A. Aubert; V. De Smedt-Peyrusse; C. Lecours; K. Bisht; L. Fourgeaud; S. Gregoire; L. Bretillon; N. Acar; N. J. Grant; J. Badaut; P. Gressens; A. Sierra; O. Butovsky; M. E. Tremblay; R. P. Bazinet; C. Joffre;

    Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in Humans. However, the n-3 PUFAs deficiency-mediated mechanisms affecting the development

    更新日期:2020-12-01
  • Light-driven formation of manganese oxide by today’s photosystem II supports evolutionarily ancient manganese-oxidizing photosynthesis
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Petko Chernev; Sophie Fischer; Jutta Hoffmann; Nicholas Oliver; Ricardo Assunção; Boram Yu; Robert L. Burnap; Ivelina Zaharieva; Dennis J. Nürnberg; Michael Haumann; Holger Dau

    Water oxidation and concomitant dioxygen formation by the manganese-calcium cluster of oxygenic photosynthesis has shaped the biosphere, atmosphere, and geosphere. It has been hypothesized that at an early stage of evolution, before photosynthetic water oxidation became prominent, light-driven formation of manganese oxides from dissolved Mn(2+) ions may have played a key role in bioenergetics and possibly

    更新日期:2020-12-01
  • Neoadjuvant FLOT versus SOX phase II randomized clinical trial for patients with locally advanced gastric cancer
    Nat. Commun. (IF 12.121) Pub Date : 2020-11-30
    Birendra Kumar Sah; Benyan Zhang; Huan Zhang; Jian Li; Fei Yuan; Tao Ma; Min Shi; Wei Xu; Zhenglun Zhu; Wentao Liu; Chao Yan; Chen Li; Bingya Liu; Min Yan; Zhenggang Zhu

    Neoadjuvant chemotherapy with docetaxel, oxaliplatin, fluorouracil, and leucovorin (FLOT regimen) has shown promising results in terms of pathological response and survival rate in patients with locally advanced resectable gastric cancer (LAGC). However, tegafur gimeracil oteracil potassium capsule (S-1) plus oxaliplatin (SOX regimen) is the preferred chemotherapy regimen in Eastern countries. Here

    更新日期:2020-12-01