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Stepwise selection on homeologous PRR genes controlling flowering and maturity during soybean domestication Nat. Genet. (IF 25.455) Pub Date : 2020-03-30 Sijia Lu; Lidong Dong; Chao Fang; Shulin Liu; Lingping Kong; Qun Cheng; Liyu Chen; Tong Su; Haiyang Nan; Dan Zhang; Lei Zhang; Zhijuan Wang; Yongqing Yang; Deyue Yu; Xiaolei Liu; Qingyong Yang; Xiaoya Lin; Yang Tang; Xiaohui Zhao; Xinquan Yang; Changen Tian; Qiguang Xie; Xia Li; Xiaohui Yuan; Zhixi Tian; Baohui Liu; James L. Weller; Fanjiang Kong
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Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia Nat. Genet. (IF 25.455) Pub Date : 2020-03-30 Pirro G. Hysi; Hélène Choquet; Anthony P. Khawaja; Robert Wojciechowski; Milly S. Tedja; Jie Yin; Mark J. Simcoe; Karina Patasova; Omar A. Mahroo; Khanh K. Thai; Phillippa M. Cumberland; Ronald B. Melles; Virginie J. M. Verhoeven; Veronique Vitart; Ayellet Segre; Richard A. Stone; Nick Wareham; Alex W. Hewitt; David A. Mackey; Caroline C. W. Klaver; Stuart MacGregor; Peng T. Khaw; Paul J. Foster; Jeremy
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Minimal phenotyping yields genome-wide association signals of low specificity for major depression Nat. Genet. (IF 25.455) Pub Date : 2020-03-30 Na Cai; Joana A. Revez; Mark J. Adams; Till F. M. Andlauer; Gerome Breen; Enda M. Byrne; Toni-Kim Clarke; Andreas J. Forstner; Hans J. Grabe; Steven P. Hamilton; Douglas F. Levinson; Cathryn M. Lewis; Glyn Lewis; Nicholas G. Martin; Yuri Milaneschi; Ole Mors; Bertram Müller-Myhsok; Brenda W. J. H. Penninx; Roy H. Perlis; Giorgio Pistis; James B. Potash; Martin Preisig; Jianxin Shi; Jordan W. Smoller;
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Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma Nat. Genet. (IF 25.455) Pub Date : 2020-03-23 David J. H. Shih; Naema Nayyar; Ivanna Bihun; Ibiayi Dagogo-Jack; Corey M. Gill; Elisa Aquilanti; Mia Bertalan; Alexander Kaplan; Megan R. D’Andrea; Ugonma Chukwueke; Franziska Maria Ippen; Christopher Alvarez-Breckenridge; Nicholas D. Camarda; Matthew Lastrapes; Devin McCabe; Ben Kuter; Benjamin Kaufman; Matthew R. Strickland; Juan Carlos Martinez-Gutierrez; Deepika Nagabhushan; Magali De Sauvage;
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DNA methylation disruption reshapes the hematopoietic differentiation landscape Nat. Genet. (IF 25.455) Pub Date : 2020-03-23 Franco Izzo; Stanley C. Lee; Asaf Poran; Ronan Chaligne; Federico Gaiti; Baptiste Gross; Rekha R. Murali; Sunil D. Deochand; Chelston Ang; Philippa Wyndham Jones; Anna S. Nam; Kyu-Tae Kim; Steven Kothen-Hill; Rafael C. Schulman; Michelle Ki; Priscillia Lhoumaud; Jane A. Skok; Aaron D. Viny; Ross L. Levine; Ephraim Kenigsberg; Omar Abdel-Wahab; Dan A. Landau
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Establishing the International Genetic Discrimination Observatory Nat. Genet. (IF 25.455) Pub Date : 2020-03-23 Yann Joly; Gratien Dalpé; Charles Dupras; Bénédicte Bévière-Boyer; Aisling de Paor; Edward S. Dove; Palmira Granados Moreno; Calvin W. L. Ho; Chih-Hsing Ho; Katharina Ó Cathaoir; Kazuto Kato; Hannah Kim; Lingqiao Song; Timo Minssen; Pilar Nicolás; Margaret Otlowski; Anya E. R. Prince; Athira P. S. Nair; Ine Van Hoyweghen; Torsten H. Voigt; Chisato Yamasaki; Yvonne Bombard
Genetic discrimination is one of the most pervasive challenges resulting from research and development in human genetics. To collaboratively study and prevent this ethical issue, we established an international Genetic Discrimination Observatory comprising a network of researchers and stakeholders from more than 19 jurisdictions.
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Evaluating and improving heritability models using summary statistics Nat. Genet. (IF 25.455) Pub Date : 2020-03-23 Doug Speed; John Holmes; David J. Balding
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Modeling the complex genetic architectures of brain disease Nat. Genet. (IF 25.455) Pub Date : 2020-03-23 Michael B. Fernando; Tim Ahfeldt; Kristen J. Brennand
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Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia Nat. Genet. (IF 25.455) Pub Date : 2020-03-23 Andreas Kloetgen; Palaniraja Thandapani; Panagiotis Ntziachristos; Yohana Ghebrechristos; Sofia Nomikou; Charalampos Lazaris; Xufeng Chen; Hai Hu; Sofia Bakogianni; Jingjing Wang; Yi Fu; Francesco Boccalatte; Hua Zhong; Elisabeth Paietta; Thomas Trimarchi; Yixing Zhu; Pieter Van Vlierberghe; Giorgio G. Inghirami; Timothee Lionnet; Iannis Aifantis; Aristotelis Tsirigos
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Enhancing African orphan crops with genomics Nat. Genet. (IF 25.455) Pub Date : 2020-03-23 Ramni Jamnadass; Rita H. Mumm; Iago Hale; Prasad Hendre; Alice Muchugi; Ian K. Dawson; Wayne Powell; Lars Graudal; Howard Yana-Shapiro; Anthony J. Simons; Allen Van Deynze
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Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer Nat. Genet. (IF 25.455) Pub Date : 2020-03-16 Kevin H. Lin; Justine C. Rutter; Abigail Xie; Bryann Pardieu; Emily T. Winn; Reinaldo Dal Bello; Antoine Forget; Raphael Itzykson; Yeong-Ran Ahn; Ziwei Dai; Raiyan T. Sobhan; Grace R. Anderson; Katherine R. Singleton; Amy E. Decker; Peter S. Winter; Jason W. Locasale; Lorin Crawford; Alexandre Puissant; Kris C. Wood
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Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones Nat. Genet. (IF 25.455) Pub Date : 2020-03-16 Makiko Iwafuchi; Isabel Cuesta; Greg Donahue; Naomi Takenaka; Anna B. Osipovich; Mark A. Magnuson; Heinrich Roder; Steven H. Seeholzer; Pilar Santisteban; Kenneth S. Zaret
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Lysine 4 of histone H3.3 is required for embryonic stem cell differentiation, histone enrichment at regulatory regions and transcription accuracy Nat. Genet. (IF 25.455) Pub Date : 2020-03-05 Maja Gehre; Daria Bunina; Simone Sidoli; Marlena J. Lübke; Nichole Diaz; Matteo Trovato; Benjamin A. Garcia; Judith B. Zaugg; Kyung-Min Noh
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The GWAS Diversity Monitor tracks diversity by disease in real time Nat. Genet. (IF 25.455) Pub Date : 2020-03-05 Melinda C. Mills; Charles Rahal
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Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution Nat. Genet. (IF 25.455) Pub Date : 2020-03-05 Saioa López; Emilia L. Lim; Stuart Horswell; Kerstin Haase; Ariana Huebner; Michelle Dietzen; Thanos P. Mourikis; Thomas B. K. Watkins; Andrew Rowan; Sally M. Dewhurst; Nicolai J. Birkbak; Gareth A. Wilson; Peter Van Loo; Mariam Jamal-Hanjani; Charles Swanton; Nicholas McGranahan
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Whole tumor genomes across cancers Nat. Genet. (IF 25.455) Pub Date : 2020-03-05
The Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium project, led by the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), coordinated the sequencing and analysis of 2,583 tumor whole genomes across 38 cancer types. This impressively large project, comprising many working groups focusing on various molecular or genetic features of cancer, has generated valuable
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Author Correction: Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat. Genet. (IF 25.455) Pub Date : 2020-02-27 Léon Kautz,Grace Jung,Erika V Valore,Stefano Rivella,Elizabeta Nemeth,Tomas Ganz
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Publisher Correction: Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma. Nat. Genet. (IF 25.455) Pub Date : 2020-02-27 Richard P Koche,Elias Rodriguez-Fos,Konstantin Helmsauer,Martin Burkert,Ian C MacArthur,Jesper Maag,Rocio Chamorro,Natalia Munoz-Perez,Montserrat Puiggròs,Heathcliff Dorado Garcia,Yi Bei,Claudia Röefzaad,Victor Bardinet,Annabell Szymansky,Annika Winkler,Theresa Thole,Natalie Timme,Katharina Kasack,Steffen Fuchs,Filippos Klironomos,Nina Thiessen,Eric Blanc,Karin Schmelz,Annette Künkele,Patrick Hundsdörfer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Silencers in the spotlight Nat. Genet. (IF 25.455) Pub Date : 2020-02-24 Monica Della Rosa; Mikhail Spivakov
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Author Correction: Human somatic cell mutagenesis creates genetically tractable sarcomas Nat. Genet. (IF 25.455) Pub Date : 2020-02-24 Sam D. Molyneux; Paul D. Waterhouse; Dawne Shelton; Yang W. Shao; Christopher M. Watling; Qing-Lian Tang; Isaac S. Harris; Brendan C. Dickson; Pirashaanthy Tharmapalan; Geir K. Sandve; Xiaoyang Zhang; Swneke D. Bailey; Hal Berman; Jay S. Wunder; Zsuzsanna Izsvák; Mathieu Lupien; Tak W. Mak; Rama Khokha
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development Nat. Genet. (IF 25.455) Pub Date : 2020-02-24 Chew Yee Ngan; Chee Hong Wong; Harianto Tjong; Wenbo Wang; Rachel L. Goldfeder; Cindy Choi; Hao He; Liang Gong; Junyan Lin; Barbara Urban; Julianna Chow; Meihong Li; Joanne Lim; Vivek Philip; Stephen A. Murray; Haoyi Wang; Chia-Lin Wei
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Systematic identification of silencers in human cells Nat. Genet. (IF 25.455) Pub Date : 2020-02-24 Baoxu Pang; Michael P. Snyder
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Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci. Nat. Genet. (IF 25.455) Pub Date : 2020-02-17 Maria Gutierrez-Arcelus,Yuriy Baglaenko,Jatin Arora,Susan Hannes,Yang Luo,Tiffany Amariuta,Nikola Teslovich,Deepak A Rao,Joerg Ermann,A Helena Jonsson,,Cristina Navarrete,Stephen S Rich,Kent D Taylor,Jerome I Rotter,Peter K Gregersen,Tonu Esko,Michael B Brenner,Soumya Raychaudhuri
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A small molecule kicks repeat expansion into reverse. Nat. Genet. (IF 25.455) Pub Date : 2020-02-14 Michael D Flower,Sarah J Tabrizi
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A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo. Nat. Genet. (IF 25.455) Pub Date : 2020-02-14 Masayuki Nakamori,Gagan B Panigrahi,Stella Lanni,Terence Gall-Duncan,Hideki Hayakawa,Hana Tanaka,Jennifer Luo,Takahiro Otabe,Jinxing Li,Akihiro Sakata,Marie-Christine Caron,Niraj Joshi,Tanya Prasolava,Karen Chiang,Jean-Yves Masson,Marc S Wold,Xiaoxiao Wang,Marietta Y W T Lee,John Huddleston,Katherine M Munson,Scott Davidson,Mehdi Layeghifard,Lisa-Monique Edward,Richard Gallon,Mauro Santibanez-Koref
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Author Correction: Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution. Nat. Genet. (IF 25.455) Pub Date : 2020-02-12 Michelle Chan-Seng-Yue,Jaeseung C Kim,Gavin W Wilson,Karen Ng,Eugenia Flores Figueroa,Grainne M O'Kane,Ashton A Connor,Robert E Denroche,Robert C Grant,Jessica McLeod,Julie M Wilson,Gun Ho Jang,Amy Zhang,Sheng-Ben Liang,Ayelet Borgida,Dianne Chadwick,Sangeetha Kalimuthu,Ilinca Lungu,John M S Bartlett,Paul M Krzyzanowski,Vandana Sandhu,Hervé Tiriac,Fieke E M Froeling,Joanna M Karasinska,James T Topham
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Publisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat. Genet. (IF 25.455) Pub Date : 2020-02-11 Yuan Yuan,Young Seok Ju,Youngwook Kim,Jun Li,Yumeng Wang,Christopher J Yoon,Yang Yang,Inigo Martincorena,Chad J Creighton,John N Weinstein,Yanxun Xu,Leng Han,Hyung-Lae Kim,Hidewaki Nakagawa,Keunchil Park,Peter J Campbell,Han Liang,
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Author Correction: Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome. Nat. Genet. (IF 25.455) Pub Date : 2020-02-07 Pierre Vabres,Arthur Sorlin,Stanislav S Kholmanskikh,Bénédicte Demeer,Judith St-Onge,Yannis Duffourd,Paul Kuentz,Jean-Benoît Courcet,Virginie Carmignac,Philippine Garret,Didier Bessis,Odile Boute,Alain Bron,Guillaume Captier,Esther Carmi,Bernard Devauchelle,David Geneviève,Catherine Gondry-Jouet,Laurent Guibaud,Arnaud Lafon,Michèle Mathieu-Dramard,Julien Thevenon,William B Dobyns,Geneviève Bernard
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nat. Genet. (IF 25.455) Pub Date : 2020-02-06 Iris E Jansen,Jeanne E Savage,Kyoko Watanabe,Julien Bryois,Dylan M Williams,Stacy Steinberg,Julia Sealock,Ida K Karlsson,Sara Hägg,Lavinia Athanasiu,Nicola Voyle,Petroula Proitsi,Aree Witoelar,Sven Stringer,Dag Aarsland,Ina S Almdahl,Fred Andersen,Sverre Bergh,Francesco Bettella,Sigurbjorn Bjornsson,Anne Brækhus,Geir Bråthen,Christiaan de Leeuw,Rahul S Desikan,Srdjan Djurovic,Logan Dumitrescu,Tormod
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Author Correction: A global overview of pleiotropy and genetic architecture in complex traits. Nat. Genet. (IF 25.455) Pub Date : 2020-02-06 Kyoko Watanabe,Sven Stringer,Oleksandr Frei,Maša Umićević Mirkov,Christiaan de Leeuw,Tinca J C Polderman,Sophie van der Sluis,Ole A Andreassen,Benjamin M Neale,Danielle Posthuma
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Necessary voices. Nat. Genet. (IF 25.455) Pub Date : 2020-02-05
Given that it is based on heredity and has the ability to trace connections, genetics as a scientific discipline should be among those most attuned to diversity and global perspectives. Indigenous communities and scientists have much to contribute to genetics research, and they are making their voices heard. We celebrate these essential members of our larger genetics community, and we look forward
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Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. Nat. Genet. (IF 25.455) Pub Date : 2020-02-05 Isidro Cortés-Ciriano,Jake June-Koo Lee,Ruibin Xi,Dhawal Jain,Youngsook L Jung,Lixing Yang,Dmitry Gordenin,Leszek J Klimczak,Cheng-Zhong Zhang,David S Pellman,,Peter J Park,
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Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. Nat. Genet. (IF 25.455) Pub Date : 2020-02-05 Nilay S Sethi,Osamu Kikuchi,Gina N Duronio,Matthew D Stachler,James M McFarland,Ruben Ferrer-Luna,Yanxi Zhang,Chunyang Bao,Roderick Bronson,Deepa Patil,Francisco Sanchez-Vega,Jie-Bin Liu,Ewa Sicinska,Jean-Bernard Lazaro,Keith L Ligon,Rameen Beroukhim,Adam J Bass
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The landscape of viral associations in human cancers. Nat. Genet. (IF 25.455) Pub Date : 2020-02-05 Marc Zapatka,Ivan Borozan,Daniel S Brewer,Murat Iskar,Adam Grundhoff,Malik Alawi,Nikita Desai,Holger Sültmann,Holger Moch,,Colin S Cooper,Roland Eils,Vincent Ferretti,Peter Lichter,
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Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nat. Genet. (IF 25.455) Pub Date : 2020-02-05 Yuan Yuan,Young Seok Ju,Youngwook Kim,Jun Li,Yumeng Wang,Christopher J Yoon,Yang Yang,Inigo Martincorena,Chad J Creighton,John N Weinstein,Yanxun Xu,Leng Han,Hyung-Lae Kim,Hidewaki Nakagawa,Keunchil Park,Peter J Campbell,Han Liang,
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Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. Nat. Genet. (IF 25.455) Pub Date : 2020-02-05 Kadir C Akdemir,Victoria T Le,Sahaana Chandran,Yilong Li,Roel G Verhaak,Rameen Beroukhim,Peter J Campbell,Lynda Chin,Jesse R Dixon,P Andrew Futreal,,
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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. Nat. Genet. (IF 25.455) Pub Date : 2020-02-05 Bernardo Rodriguez-Martin,Eva G Alvarez,Adrian Baez-Ortega,Jorge Zamora,Fran Supek,Jonas Demeulemeester,Martin Santamarina,Young Seok Ju,Javier Temes,Daniel Garcia-Souto,Harald Detering,Yilong Li,Jorge Rodriguez-Castro,Ana Dueso-Barroso,Alicia L Bruzos,Stefan C Dentro,Miguel G Blanco,Gianmarco Contino,Daniel Ardeljan,Marta Tojo,Nicola D Roberts,Sonia Zumalave,Paul A W Edwards,Joachim Weischenfeldt
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Identification of cancer driver genes based on nucleotide context. Nat. Genet. (IF 25.455) Pub Date : 2020-02-03 Felix Dietlein,Donate Weghorn,Amaro Taylor-Weiner,André Richters,Brendan Reardon,David Liu,Eric S Lander,Eliezer M Van Allen,Shamil R Sunyaev
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Genomic landscape of lung adenocarcinoma in East Asians. Nat. Genet. (IF 25.455) Pub Date : 2020-02-03 Jianbin Chen,Hechuan Yang,Audrey Su Min Teo,Lidyana Bte Amer,Faranak Ghazi Sherbaf,Chu Quan Tan,Jacob Josiah Santiago Alvarez,Bingxin Lu,Jia Qi Lim,Angela Takano,Rahul Nahar,Yin Yeng Lee,Cheryl Zi Jin Phua,Khi Pin Chua,Lisda Suteja,Pauline Jieqi Chen,Mei Mei Chang,Tina Puay Theng Koh,Boon-Hean Ong,Devanand Anantham,Anne Ann Ling Hsu,Apoorva Gogna,Chow Wei Too,Zaw Win Aung,Yi Fei Lee,Lanying Wang,Tony
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Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. Nat. Genet. (IF 25.455) Pub Date : 2020-01-31 Sankari Nagarajan,Shalini V Rao,Joseph Sutton,Danya Cheeseman,Shanade Dunn,Evangelia K Papachristou,Jose-Enrique Gonzalez Prada,Dominique-Laurent Couturier,Sanjeev Kumar,Kamal Kishore,Chandra Sekhar Reddy Chilamakuri,Silvia-Elena Glont,Emily Archer Goode,Cara Brodie,Naomi Guppy,Rachael Natrajan,Alejandra Bruna,Carlos Caldas,Alasdair Russell,Rasmus Siersbæk,Kosuke Yusa,Igor Chernukhin,Jason S Carroll
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression. Nat. Genet. (IF 25.455) Pub Date : 2020-01-20 Jamie E Craig,Xikun Han,Ayub Qassim,Mark Hassall,Jessica N Cooke Bailey,Tyler G Kinzy,Anthony P Khawaja,Jiyuan An,Henry Marshall,Puya Gharahkhani,Robert P Igo,Stuart L Graham,Paul R Healey,Jue-Sheng Ong,Tiger Zhou,Owen Siggs,Matthew H Law,Emmanuelle Souzeau,Bronwyn Ridge,Pirro G Hysi,Kathryn P Burdon,Richard A Mills,John Landers,Jonathan B Ruddle,Ashish Agar,Anna Galanopoulos,Andrew J R White,Colin
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Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans. Nat. Genet. (IF 25.455) Pub Date : 2020-01-20 Pascal Schlosser,Yong Li,Peggy Sekula,Johannes Raffler,Franziska Grundner-Culemann,Maik Pietzner,Yurong Cheng,Matthias Wuttke,Inga Steinbrenner,Ulla T Schultheiss,Fruzsina Kotsis,Tim Kacprowski,Lukas Forer,Birgit Hausknecht,Arif B Ekici,Matthias Nauck,Uwe Völker,,Gerd Walz,Peter J Oefner,Florian Kronenberg,Robert P Mohney,Michael Köttgen,Karsten Suhre,Kai-Uwe Eckardt,Gabi Kastenmüller,Anna Köttgen
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Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nat. Genet. (IF 25.455) Pub Date : 2020-01-20 Anindita Basak,Mathias Munschauer,Caleb A Lareau,Kara E Montbleau,Jacob C Ulirsch,Christina R Hartigan,Monica Schenone,John Lian,Yaomei Wang,Yumin Huang,Xianfang Wu,Lee Gehrke,Charles M Rice,Xiuli An,Helen A Christou,Narla Mohandas,Steven A Carr,Jane-Jane Chen,Stuart H Orkin,Eric S Lander,Vijay G Sankaran
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Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution. Nat. Genet. (IF 25.455) Pub Date : 2020-01-13 Michelle Chan-Seng-Yue,Jaeseung C Kim,Gavin W Wilson,Karen Ng,Eugenia Flores Figueroa,Grainne M O'Kane,Ashton A Connor,Robert E Denroche,Robert C Grant,Jessica McLeod,Julie M Wilson,Gun Ho Jang,Amy Zhang,Anna Dodd,Sheng-Ben Liang,Ayelet Borgida,Dianne Chadwick,Sangeetha Kalimuthu,Ilinca Lungu,John M S Bartlett,Paul M Krzyzanowski,Vandana Sandhu,Hervé Tiriac,Fieke E M Froeling,Joanna M Karasinska,James
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ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nat. Genet. (IF 25.455) Pub Date : 2020-01-13 Guotai Xu,Sagar Chhangawala,Emiliano Cocco,Pedram Razavi,Yanyan Cai,Jordan E Otto,Lorenzo Ferrando,Pier Selenica,Erik Ladewig,Carmen Chan,Arnaud Da Cruz Paula,Matthew Witkin,Yuanming Cheng,Jane Park,Cristian Serna-Tamayo,HuiYong Zhao,Fan Wu,Mirna Sallaku,Xuan Qu,Alison Zhao,Clayton K Collings,Andrew R D'Avino,Komal Jhaveri,Richard Koche,Ross L Levine,Jorge S Reis-Filho,Cigall Kadoch,Maurizio Scaltriti
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On the existence and functionality of topologically associating domains. Nat. Genet. (IF 25.455) Pub Date : 2020-01-10 Jonathan A Beagan,Jennifer E Phillips-Cremins
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ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. Nat. Genet. (IF 25.455) Pub Date : 2020-01-06 Sankari Nagarajan,Shalini V Rao,Joseph Sutton,Danya Cheeseman,Shanade Dunn,Evangelia K Papachristou,Jose-Enrique Gonzalez Prada,Dominique-Laurent Couturier,Sanjeev Kumar,Kamal Kishore,Chandra Sekhar Reddy Chilamakuri,Silvia-Elena Glont,Emily Archer Goode,Cara Brodie,Naomi Guppy,Rachael Natrajan,Alejandra Bruna,Carlos Caldas,Alasdair Russell,Rasmus Siersbæk,Kosuke Yusa,Igor Chernukhin,Jason S Carroll
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Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes. Nat. Genet. (IF 25.455) Pub Date : 2020-01-07 Laura Fachal,Hugues Aschard,Jonathan Beesley,Daniel R Barnes,Jamie Allen,Siddhartha Kar,Karen A Pooley,Joe Dennis,Kyriaki Michailidou,Constance Turman,Penny Soucy,Audrey Lemaçon,Michael Lush,Jonathan P Tyrer,Maya Ghoussaini,Mahdi Moradi Marjaneh,Xia Jiang,Simona Agata,Kristiina Aittomäki,M Rosario Alonso,Irene L Andrulis,Hoda Anton-Culver,Natalia N Antonenkova,Adalgeir Arason,Volker Arndt,Kristan J
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Navigating 2020 and beyond. Nat. Genet. (IF 25.455) Pub Date : 2020-01-07
As we usher in a new year of a new decade and ponder what the future will bring for the genetics field, we wish to reflect on some specific areas related to diversity, privacy and genome editing that require attention and vigilance from the community.
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RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons. Nat. Genet. (IF 25.455) Pub Date : 2020-01-07 James D Thomas,Jacob T Polaski,Qing Feng,Emma J De Neef,Emma R Hoppe,Maria V McSharry,Joseph Pangallo,Austin M Gabel,Andrea E Belleville,Jacqueline Watson,Naomi T Nkinsi,Alice H Berger,Robert K Bradley
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Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma. Nat. Genet. (IF 25.455) Pub Date : 2020-01-06 Ayesha Noorani,Xiaodun Li,Martin Goddard,Jason Crawte,Ludmil B Alexandrov,Maria Secrier,Matthew D Eldridge,Lawrence Bower,Jamie Weaver,Pierre Lao-Sirieix,Inigo Martincorena,Irene Debiram-Beecham,Nicola Grehan,Shona MacRae,Shalini Malhotra,Ahmad Miremadi,Tabitha Thomas,Sarah Galbraith,Lorraine Petersen,Stephen D Preston,David Gilligan,Andrew Hindmarsh,Richard H Hardwick,Michael R Stratton,David C Wedge
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The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins. Nat. Genet. (IF 25.455) Pub Date : 2020-01-06 Kushal Suryamohan,Sajesh P Krishnankutty,Joseph Guillory,Matthew Jevit,Markus S Schröder,Meng Wu,Boney Kuriakose,Oommen K Mathew,Rajadurai C Perumal,Ivan Koludarov,Leonard D Goldstein,Kate Senger,Mandumpala Davis Dixon,Dinesh Velayutham,Derek Vargas,Subhra Chaudhuri,Megha Muraleedharan,Ridhi Goel,Ying-Jiun J Chen,Aakrosh Ratan,Peter Liu,Brendan Faherty,Guillermo de la Rosa,Hiroki Shibata,Miriam Baca
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GeVIR is a continuous gene-level metric that uses variant distribution patterns to prioritize disease candidate genes. Nat. Genet. (IF 25.455) Pub Date : 2019-12-23 Nikita Abramovs,Andrew Brass,May Tassabehji
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m6A RNA modification as a new player in R-loop regulation. Nat. Genet. (IF 25.455) Pub Date : 2019-12-23 Aline Marnef,Gaëlle Legube
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A call for global action for rare diseases in Africa. Nat. Genet. (IF 25.455) Pub Date : 2019-12-23 Gareth S Baynam,Stephen Groft,Francois H van der Westhuizen,Safiyya D Gassman,Kelly du Plessis,Emily P Coles,Eda Selebatso,Moses Selebatso,Boikobo Gaobinelwe,Tebogo Selebatso,Dipesalema Joel,Virginia A Llera,Barend C Vorster,Barbara Wuebbels,Benjamin Djoudalbaye,Christopher P Austin,Judit Kumuthini,John Forman,Petra Kaufmann,James Chipeta,Désirée Gavhed,Annika Larsson,Maja Stojiljkovic,Ann Nordgren
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Identifying cross-disease components of genetic risk across hospital data in the UK Biobank. Nat. Genet. (IF 25.455) Pub Date : 2019-12-23 Adrian Cortes,Patrick K Albers,Calliope A Dendrou,Lars Fugger,Gil McVean
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Resequencing of 683 common bean genotypes identifies yield component trait associations across a north-south cline. Nat. Genet. (IF 25.455) Pub Date : 2019-12-23 Jing Wu,Lanfen Wang,Junjie Fu,Jibao Chen,Shuhong Wei,Shilong Zhang,Jie Zhang,Yongsheng Tang,Mingli Chen,Jifeng Zhu,Lei Lei,Qinghe Geng,Chunliang Liu,Lei Wu,Xiaoming Li,Xiaoli Wang,Qiang Wang,Zhaoli Wang,Shilai Xing,Haikuan Zhang,Matthew W Blair,Shumin Wang
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Reply to: Revisiting the origin of octoploid strawberry. Nat. Genet. (IF 25.455) Pub Date : 2019-12-16 Patrick P Edger,Michael R McKain,Alan E Yocca,Steven J Knapp,Qin Qiao,Ticao Zhang
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N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nat. Genet. (IF 25.455) Pub Date : 2019-12-16 Abdulkadir Abakir,Tom C Giles,Agnese Cristini,Jeremy M Foster,Nan Dai,Marta Starczak,Alejandro Rubio-Roldan,Miaomiao Li,Maria Eleftheriou,James Crutchley,Luke Flatt,Lorraine Young,Daniel J Gaffney,Chris Denning,Bjørn Dalhus,Richard D Emes,Daniel Gackowski,Ivan R Corrêa,Jose L Garcia-Perez,Arne Klungland,Natalia Gromak,Alexey Ruzov
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Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma. Nat. Genet. (IF 25.455) Pub Date : 2019-12-16 Richard P Koche,Elias Rodriguez-Fos,Konstantin Helmsauer,Martin Burkert,Ian C MacArthur,Jesper Maag,Rocio Chamorro,Natalia Munoz-Perez,Montserrat Puiggròs,Heathcliff Dorado Garcia,Yi Bei,Claudia Röefzaad,Victor Bardinet,Annabell Szymansky,Annika Winkler,Theresa Thole,Natalie Timme,Katharina Kasack,Steffen Fuchs,Filippos Klironomos,Nina Thiessen,Eric Blanc,Karin Schmelz,Annette Künkele,Patrick Hundsdörfer
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