-
A human lymphoma organoid model for evaluating and targeting the follicular lymphoma tumor immune microenvironment Cell Stem Cell (IF 23.9) Pub Date : 2024-02-22 Jenna M. Kastenschmidt, Joseph G. Schroers-Martin, Brian J. Sworder, Suhas Sureshchandra, Michael S. Khodadoust, Chih Long Liu, Mari Olsen, David M. Kurtz, Maximilian Diehn, Lisa E. Wagar, Ash A. Alizadeh
Heterogeneity in the tumor microenvironment (TME) of follicular lymphomas (FLs) can affect clinical outcomes. Current immunotherapeutic strategies, including antibody- and cell-based therapies, variably overcome pro-tumorigenic mechanisms for sustained disease control. Modeling the intact FL TME, with its native, syngeneic tumor-infiltrating leukocytes, is a major challenge. Here, we describe an organoid
-
An iron rheostat controls hematopoietic stem cell fate Cell Stem Cell (IF 23.9) Pub Date : 2024-02-22 Yun-Ruei Kao, Jiahao Chen, Rajni Kumari, Anita Ng, Aliona Zintiridou, Madhuri Tatiparthy, Yuhong Ma, Maria M. Aivalioti, Deeposree Moulik, Sriram Sundaravel, Daqian Sun, Julie A. Reisz, Juliane Grimm, Nuria Martinez-Lopez, Stephanie Stransky, Simone Sidoli, Ulrich Steidl, Rajat Singh, Angelo D’Alessandro, Britta Will
Mechanisms governing the maintenance of blood-producing hematopoietic stem and multipotent progenitor cells (HSPCs) are incompletely understood, particularly those regulating fate, ensuring long-term maintenance, and preventing aging-associated stem cell dysfunction. We uncovered a role for transitory free cytoplasmic iron as a rheostat for adult stem cell fate control. We found that HSPCs harbor comparatively
-
Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury Cell Stem Cell (IF 23.9) Pub Date : 2024-02-22 Shuyong Wang, Xuan Wang, Yiran Shan, Zuolong Tan, Yuxin Su, Yannan Cao, Shuang Wang, Jiahong Dong, Jin Gu, Yunfang Wang
Liver injuries often occur in a zonated manner. However, detailed regenerative responses to such zonal injuries at cellular and molecular levels remain largely elusive. By using a fate-mapping strain, , to elucidate liver regeneration after acute pericentral injury, we found that pericentral regeneration is primarily compensated by the expansion of remaining pericentral hepatocytes, and secondarily
-
Hallmarks of totipotent and pluripotent stem cell states Cell Stem Cell (IF 23.9) Pub Date : 2024-02-20 Peng Du, Jun Wu
Though totipotency and pluripotency are transient during early embryogenesis, they establish the foundation for the development of all mammals. Studying these has been challenging due to limited access and ethical constraints, particularly in humans. Recent progress has led to diverse culture adaptations of epiblast cells in the form of totipotent and pluripotent stem cells, which not only deepen our
-
Thalamocortical organoids enable in vitro modeling of 22q11.2 microdeletion associated with neuropsychiatric disorders Cell Stem Cell (IF 23.9) Pub Date : 2024-02-20 David Shin, Chang N. Kim, Jayden Ross, Kelsey M. Hennick, Sih-Rong Wu, Neha Paranjape, Rachel Leonard, Jerrick C. Wang, Matthew G. Keefe, Bryan J. Pavlovic, Kevin C. Donohue, Clara Moreau, Emilie M. Wigdor, H. Hanh Larson, Denise E. Allen, Cathryn R. Cadwell, Aparna Bhaduri, Galina Popova, Carrie E. Bearden, Alex A. Pollen, Sebastien Jacquemont, Stephan J. Sanders, David Haussler, Arun P. Wiita, Nicholas
Thalamic dysfunction has been implicated in multiple psychiatric disorders. We sought to study the mechanisms by which abnormalities emerge in the context of the 22q11.2 microdeletion, which confers significant genetic risk for psychiatric disorders. We investigated early stages of human thalamus development using human pluripotent stem cell-derived organoids and show that the 22q11.2 microdeletion
-
Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes Cell Stem Cell (IF 23.9) Pub Date : 2024-02-15 Kavita Raniga, Aishah Nasir, Nguyen T.N. Vo, Ravi Vaidyanathan, Sarah Dickerson, Simon Hilcove, Diogo Mosqueira, Gary R. Mirams, Peter Clements, Ryan Hicks, Amy Pointon, Will Stebbeds, Jo Francis, Chris Denning
Advances in hiPSC isolation and reprogramming and hPSC-CM differentiation have prompted their therapeutic application and utilization for evaluating potential cardiovascular safety liabilities. In this perspective, we showcase key efforts toward the large-scale production of hiPSC-CMs, implementation of hiPSC-CMs in industry settings, and recent clinical applications of this technology. The key observations
-
Canonical Wnt signaling directs the generation of functional human PSC-derived atrioventricular canal cardiomyocytes in bioprinted cardiac tissues Cell Stem Cell (IF 23.9) Pub Date : 2024-02-15 Chenxi Ye, Chuanlai Yang, Heqiang Zhang, Rui Gao, Yingnan Liao, Yali Zhang, Lingjun Jie, Yanhui Zhang, Tong Cheng, Yan Wang, Jie Ren
The creation of a functional 3D bioprinted human heart remains challenging, largely due to the lack of some crucial cardiac cell types, including the atrioventricular canal (AVC) cardiomyocytes, which are essential to slow down the electrical impulse between the atrium and ventricle. By utilizing single-cell RNA sequencing analysis and a 3D bioprinting technology, we discover that stage-specific activation
-
Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate Cell Stem Cell (IF 23.9) Pub Date : 2024-02-08 Xiaomeng Hu, Kathy White, Chi Young, Ari G. Olroyd, Paul Kievit, Andrew J. Connolly, Tobias Deuse, Sonja Schrepfer
Allogeneic transplantation of pancreatic islets for patients with difficult-to-control diabetes mellitus is severely hampered by the requirement for continuous immunosuppression and its associated morbidity. We report that allogeneic transplantation of genetically engineered (B2M, CIITA, CD47), primary, hypoimmune, pseudo-islets (p-islets) results in their engraftment into a fully immunocompetent,
-
Bioprinting functional neural networks Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 S, t, e, p, h, a, n, i, e, , M, ., , W, i, l, l, e, r, t, h
3D printing human tissue models derived from stem cells provides an increasingly popular tissue engineering strategy for probing biological questions. Here Yan et al.1 demonstrate how this technology can be used to model mature human neural tissues with functional neural networks in healthy and disease states.
-
What is the scope of Cell Stem Cell now and in the future? Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Sheila Chari, Catherine Landis, Quan Wang, Christine Weber
Abstract not available
-
Unraveling the brain’s response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Ilse Eidhof, Daniel Twohig, Anna Falk
COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.
-
Extra (embryonic) dialogues: Keys to improved stem cell-based embryo models Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Arun Pandian Chandrasekaran, Mo Li
Despite advances in stem cell cultures, modeling early human development with stem cells in a dish remains challenging. Research by Hislop et al.,1 Okubo et al.,2 and Wei et al.3 paves the way for improved in vitro embryo models and culture conditions, offering valuable insights for regenerative medicine.
-
Sham surgery for the trialing of cell-based therapies to the CNS may not be necessary Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Viviane Tabar, Roger A. Barker
Sham surgery is often required for cell therapies adopting a randomized placebo-controlled double-blinded trial design. Using the case of dopamine neuron therapy for Parkinson’s disease, we argue that alternative trial designs should be considered instead, for several reasons relating to ethics, patient burden, ease of unblinding, and cost.
-
Metabolic regulation of the hallmarks of stem cell biology Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Benjamin T. Jackson, Lydia W.S. Finley
Stem cells perform many different functions, each of which requires specific metabolic adaptations. Over the past decades, studies of pluripotent and tissue stem cells have uncovered a range of metabolic preferences and strategies that correlate with or exert control over specific cell states. This review aims to describe the common themes that emerge from the study of stem cell metabolism: (1) metabolic
-
3D bioprinting of human neural tissues with functional connectivity Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Yuanwei Yan, Xueyan Li, Yu Gao, Sakthikumar Mathivanan, Linghai Kong, Yunlong Tao, Yi Dong, Xiang Li, Anita Bhattacharyya, Xinyu Zhao, Su-Chun Zhang
-
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Chun-Wei Chen, Linda Zhang, Ravi Dutta, Abhishek Niroula, Peter G. Miller, Christopher J. Gibson, Alexander G. Bick, Jaime M. Reyes, Yi-Tang Lee, Ayala Tovy, Tianpeng Gu, Sarah Waldvogel, Yi-Hung Chen, Bryan J. Venters, Pierre-Olivier Estève, Sriharsa Pradhan, Michael-Christopher Keogh, Pradeep Natarajan, Koichi Takahashi, Adam S. Sperling, Margaret A. Goodell
Abstract not available
-
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson’s disease Cell Stem Cell (IF 23.9) Pub Date : 2024-02-01 Sanghyun Park, Chan Wook Park, Jang Hyeon Eom, Mi-Young Jo, Hye-Jin Hur, Sung Kyoung Choi, Jae Souk Lee, Seung Taek Nam, Ki-Sang Jo, Young Woo Oh, Jungil Lee, Sieun Kim, Do-Hun Kim, Chul-Yong Park, Su Jin Kim, Ho-Young Lee, Myung Soo Cho, Dae-Sung Kim, Dong-Wook Kim
Abstract not available
-
SARS-CoV-2 infection causes dopaminergic neuron senescence Cell Stem Cell (IF 23.9) Pub Date : 2024-01-17 Liuliu Yang, Tae Wan Kim, Yuling Han, Manoj S. Nair, Oliver Harschnitz, Jiajun Zhu, Pengfei Wang, So Yeon Koo, Lauretta A. Lacko, Vasuretha Chandar, Yaron Bram, Tuo Zhang, Wei Zhang, Feng He, Chendong Pan, Junjie Wu, Yaoxing Huang, Todd Evans, Paul van der Valk, Maarten J. Titulaer, Jochem K.H. Spoor, Robert L. Furler O’Brien, Marianna Bugiani, Wilma D.J. Van de Berg, Robert E. Schwartz, David D. Ho
-
Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy Cell Stem Cell (IF 23.9) Pub Date : 2024-01-17 Qian Li, Andrew Sharkey, Megan Sheridan, Elisa Magistrati, Anna Arutyunyan, Oisin Huhn, Carmen Sancho-Serra, Holly Anderson, Naomi McGovern, Laura Esposito, Ridma Fernando, Lucy Gardner, Roser Vento-Tormo, Margherita Yayoi Turco, Ashley Moffett
-
Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis Cell Stem Cell (IF 23.9) Pub Date : 2024-01-16 Xia Kang, Jin Qian, You-xing Shi, Xu-ting Bian, Li-dan Zhang, Gao-ming Li, Li-ting Wang, Jing Zhao, Zhen-yu Dong, Meng-meng Yang, Yu-Jia-Nan Chen, Kang-lai Tang, Hong-ming Miao
-
Human conjunctiva organoids to study ocular surface homeostasis and disease Cell Stem Cell (IF 23.9) Pub Date : 2024-01-11 Marie Bannier-Hélaouët, Jeroen Korving, Ziliang Ma, Harry Begthel, Amir Giladi, Mart M. Lamers, Willine J. van de Wetering, Nobuyo Yawata, Makoto Yawata, Vanessa L.S. LaPointe, Mor M. Dickman, Rachel Kalmann, Saskia M. Imhoff, Johan H. van Es, Carmen López-Iglesias, Peter J. Peters, Bart L. Haagmans, Wei Wu, Hans Clevers
-
A time- and single-cell-resolved model of murine bone marrow hematopoiesis Cell Stem Cell (IF 23.9) Pub Date : 2024-01-05 Iwo Kucinski, Joana Campos, Melania Barile, Francesco Severi, Natacha Bohin, Pedro N. Moreira, Lewis Allen, Hannah Lawson, Myriam L.R. Haltalli, Sarah J. Kinston, Dónal O'Carroll, Kamil R. Kranc, Berthold Göttgens
-
The KRAS tour: Studying metabolic reprogramming in isogenic pancreatic cancer organoids Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 Shree Bose, Xiling Shen
Using an isogenic organoid platform to model pancreatic cancer, Duan et al. establish an important link between mutant KRAS and cholesterol metabolism and identify perhexiline maleate as a possible therapeutic to target this relationship.
-
Hallmarks of stemness in mammalian tissues Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 Joep Beumer, Hans Clevers
All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function of stem cells is best defined by their capacity to replace lost tissue through division. We discuss a set of six complementary hallmarks that are key
-
Improving cellular diversity in human cerebellar organoids Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 Marilyn Steyert, Tomasz Nowakowski
The developing human cerebellum has a greater diversity of progenitor types than that of the mouse, necessitating a human-based model for studying cerebellar development and disease. Atamian et al.1 developed a 3D organoid model of cerebellar development, which recapitulates many cell types found in the developing human cerebellum, including Purkinje-neuron-like cells.
-
Scaling up GMP-grade dopaminergic cells for Parkinson’s disease Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 T, h, o, m, a, s, , F, o, l, t, y, n, i, e
Stem cell therapy for Parkinson’s disease requires demonstration of safety and efficacy of dopaminergic cells derived from a cell line, consideration of dose, and whether this is deliverable at scale. Park et al. demonstrate these requirements for a new hESC line and that their manufacturing methods allow for its scalability.
-
Human cerebellar organoids with functional Purkinje cells Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 Alexander Atamian, Marcella Birtele, Negar Hosseini, Tuan Nguyen, Anoothi Seth, Ashley Del Dosso, Sandeep Paul, Neil Tedeschi, Ryan Taylor, Marcelo P. Coba, Ranmal Samarasinghe, Carlos Lois, Giorgia Quadrato
-
Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 Meng Liu, Chao Zhang, Ximing Gong, Tian Zhang, Michelle Mulan Lian, Elaine Guo Yan Chew, Angelysia Cardilla, Keiichiro Suzuki, Huamin Wang, Yuan Yuan, Yan Li, Mihir Yogesh Naik, Yixuan Wang, Bingrui Zhou, Wei Ze Soon, Emi Aizawa, Pin Li, Jian Hui Low, Moses Tandiono, Enrique Montagud, Daniel Moya–Rull, Concepcion Rodriguez Esteban, Yosu Luque, Mingliang Fang, Chiea Chuen Khor, Nuria Montserrat, Josep
-
Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk Cell Stem Cell (IF 23.9) Pub Date : 2024-01-04 Jason J. Northey, Mary-Kate Hayward, Yoshihiro Yui, Connor Stashko, FuiBoon Kai, Janna K. Mouw, Dhruv Thakar, Jonathon N. Lakins, Alastair J. Ironside, Susan Samson, Rita A. Mukhtar, E. Shelley Hwang, Valerie M. Weaver
-
A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS Cell Stem Cell (IF 23.9) Pub Date : 2023-12-26 Xiaohua Duan, Tuo Zhang, Lingling Feng, Neranjan de Silva, Benjamin Greenspun, Xing Wang, Jenna Moyer, M. Laura Martin, Rohit Chandwani, Olivier Elemento, Steven D. Leach, Todd Evans, Shuibing Chen, Fong Cheng Pan
-
Niche inflammatory signals control oscillating mammary regeneration and protect stem cells from cytotoxic stress Cell Stem Cell (IF 23.9) Pub Date : 2023-12-22 Chunye Liu, Yishu Xu, Guowei Yang, Yu Tao, Jiali Chang, Shihui Wang, Tom H. Cheung, Jianfeng Chen, Yi Arial Zeng
-
Highly cooperative chimeric super-SOX induces naive pluripotency across species Cell Stem Cell (IF 23.9) Pub Date : 2023-12-22 Caitlin M. MacCarthy, Guangming Wu, Vikas Malik, Yotam Menuchin-Lasowski, Taras Velychko, Gal Keshet, Rui Fan, Ivan Bedzhov, George M. Church, Ralf Jauch, Vlad Cojocaru, Hans R. Schöler, Sergiy Velychko
-
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease Cell Stem Cell (IF 23.9) Pub Date : 2023-12-11 Sanghyun Park, Chan Wook Park, Jang Hyeon Eom, Mi-Young Jo, Hye-Jin Hur, Sung Kyoung Choi, Jae Souk Lee, Seung Taek Nam, Ki-Sang Jo, Young Woo Oh, Jungil Lee, Sieun Kim, Do-Hun Kim, Chul-Yong Park, Su Jin Kim, Ho-Young Lee, Myung Soo Cho, Dae-Sung Kim, Dong-Wook Kim
-
Enchanted by the earliest stages of human life Cell Stem Cell (IF 23.9) Pub Date : 2023-12-07 Sarah Stanley
Editors’ note: The Ogawa-Yamanaka Stem Cell Prize recognizes groundbreaking work in translational regenerative medicine using reprogrammed cells. The prize is supported by Gladstone Institutes, in partnership with Cell Press. Magdalena Zernicka-Goetz, recipient of the 2023 Ogawa-Yamanaka Stem Cell Prize, has created self-assembling embryo-like models that are advancing regenerative medicine.
-
Generation of transgene-free hematopoietic stem cells from human induced pluripotent stem cells Cell Stem Cell (IF 23.9) Pub Date : 2023-12-07 Olivier Piau, Mathias Brunet-Manquat, Bruno L’Homme, Laurence Petit, Brigitte Birebent, Christine Linard, Laetitia Moeckes, Thomas Zuliani, Hélène Lapillonne, Marc Benderitter, Luc Douay, Alain Chapel, Laurence Guyonneau-Harmand, Thierry Jaffredo
-
SON is an essential m6A target for hematopoietic stem cell fate Cell Stem Cell (IF 23.9) Pub Date : 2023-12-07 Hanzhi Luo, Mariela Cortés-López, Cyrus L. Tam, Michael Xiao, Isaac Wakiro, Karen L. Chu, Aspen Pierson, Mandy Chan, Kathryn Chang, Xuejing Yang, Daniel Fecko, Grace Han, Eun-Young Erin Ahn, Quaid D. Morris, Dan A. Landau, Michael G. Kharas
-
Apart and back again: Reestablished neuronal connections restore walking after paralysis Cell Stem Cell (IF 23.9) Pub Date : 2023-12-07 Qi Lin Cao, Chrystine M. Gallegos, Yiyan Zheng
Despite significant strides promoting axon regeneration after spinal cord injury (SCI), meaningful functional recovery remains elusive. Using a combination of approaches, Squair et al.1 elegantly demonstrate that axons damaged after SCI must be reconnected with their natural targets to recover lost neurological functions.
-
Toward a CRISPR understanding of gene function in human brain development Cell Stem Cell (IF 23.9) Pub Date : 2023-12-07 Emmy Li, Martin Kampmann
Genome-wide association studies pinpoint genetic risk factors for neurodevelopmental disorders (NDDs), but the next challenge is to understand the mechanisms through which these genes affect brain development. Two recent CRISPR screens in human brain organoids1,2 interrogate the function of risk genes for autism spectrum disorder and other NDDs.
-
Breathing room: Toward next-generation tracheal engineering Cell Stem Cell (IF 23.9) Pub Date : 2023-12-07 Alexandra A. Dumas, Ryan M. Friedman, Kyra W.Y. Smith, Riccardo Gottardi
The creation of an engineered trachea with robust phenotype and sufficient mechanical properties for clinical application remains a challenge. In their work, Tang et al.1 propose a stacked approach of alternating cartilaginous and fibrous rings to form a tracheal segment, which integrated and retain patency in rabbits for 8 weeks.
-
Safety and stable survival of stem-cell-derived retinal organoid for 2 years in patients with retinitis pigmentosa Cell Stem Cell (IF 23.9) Pub Date : 2023-12-07 Yasuhiko Hirami, Michiko Mandai, Sunao Sugita, Akiko Maeda, Tadao Maeda, Midori Yamamoto, Hirofumi Uyama, Satoshi Yokota, Masashi Fujihara, Masataka Igeta, Takashi Daimon, Kanako Fujita, Tomoko Ito, Naoki Shibatani, Chikako Morinaga, Tetsuya Hayama, Aya Nakamura, Kazuki Ueyama, Keiichi Ono, Hidetaka Ohara, Yasuo Kurimoto
-
VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis Cell Stem Cell (IF 23.9) Pub Date : 2023-11-28 Fatima Rizvi, Yu-Ri Lee, Ricardo Diaz-Aragon, Pushpinder S. Bawa, Juhoon So, Rodrigo M. Florentino, Susan Wu, Arianna Sarjoo, Emily Truong, Anna R. Smith, Feiya Wang, Elissa Everton, Alina Ostrowska, Kyounghwa Jung, Ying Tam, Hiromi Muramatsu, Norbert Pardi, Drew Weissman, Alejandro Soto-Gutierrez, Donghun Shin, Valerie Gouon-Evans
-
Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis Cell Stem Cell (IF 23.9) Pub Date : 2023-11-27 Maurizio A. Leone, Maurizio Gelati, Daniela C. Profico, Claudio Gobbi, Emanuele Pravatà, Massimiliano Copetti, Carlo Conti, Lucrezia Abate, Luigi Amoruso, Francesco Apollo, Rosario F. Balzano, Ilaria Bicchi, Massimo Carella, Alessandro Ciampini, Carlo Colosimo, Paola Crociani, Giada D’Aloisio, Pietro Di Viesti, Daniela Ferrari, Danilo Fogli, Angelo L. Vescovi
-
Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs Cell Stem Cell (IF 23.9) Pub Date : 2023-11-20 Wenyan Han, Hou-Yuan Qiu, Shangwu Sun, Zhi-Can Fu, Guo-Quan Wang, Xiaowen Qian, Lijie Wang, Xiaowen Zhai, Jia Wei, Yichuan Wang, Yi-Lin Guo, Guo-Hua Cao, Rui-Jin Ji, Yi-Zhou Zhang, Hongxia Ma, Hongsheng Wang, Mingli Zhao, Jing Wu, Lili Bi, Qiu-Bing Chen, Ying Zhang
-
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon Cell Stem Cell (IF 23.9) Pub Date : 2023-11-02 Jorge O. Múnera, Daniel O. Kechele, Carine Bouffi, Na Qu, Ran Jing, Pritiprasanna Maity, Jacob R. Enriquez, Lu Han, Ian Campbell, Maxime M. Mahe, Heather A. McCauley, Xinghao Zhang, Nambirajan Sundaram, Jonathan R. Hudson, Adrian Zarsozo-Lacoste, Suman Pradhan, Kentaro Tominaga, J. Guillermo Sanchez, Alison A. Weiss, Praneet Chatuvedi, James M. Wells
-
Meningeal lymphatics stem cognitive decline in craniosynostosis Cell Stem Cell (IF 23.9) Pub Date : 2023-11-02 Taylor J. Stevenson, Kate Hitpass Romero, Justin Rustenhoven
Craniosynostosis is a congenital craniofacial disorder where premature fusion of cranial sutures causes elevated intracranial pressure and neurological deficits. In this issue of Cell Stem Cell, Ma et al. demonstrate that replenishing skull progenitor cells alleviates intracranial pressure elevations in craniosynostosis by restoring the meningeal lymphatic system, improving neurocognitive function
-
Transitional cell states sculpt tissue topology during lung regeneration Cell Stem Cell (IF 23.9) Pub Date : 2023-11-02 Arvind Konkimalla, Satoshi Konishi, Lauren Macadlo, Yoshihiko Kobayashi, Zachary J. Farino, Naoya Miyashita, Léa El Haddad, Jeremy Morowitz, Christina E. Barkauskas, Pankaj Agarwal, Tomokazu Souma, Mai K. ElMallah, Aleksandra Tata, Purushothama Rao Tata
-
Hiding from allogeneic NK cells and macrophages by a synthetic receptor Cell Stem Cell (IF 23.9) Pub Date : 2023-11-02 Akitsu Hotta, Joseph Lee
Immune attack by natural killer (NK) cells is a major hurdle for allogeneic off-the-shelf cell therapy, especially when HLA molecules are removed. Gravina et al.1 utilized a membrane-anchored single-chain antibody (scFv) as a synthetic receptor, named “synthetic immune checkpoint engager,” to prevent attack from NK cells and macrophages.
-
Multilineage circuits of regenerative cell states Cell Stem Cell (IF 23.9) Pub Date : 2023-11-02 Janine Gote-Schniering, Herbert B. Schiller
Regenerating the lungs’ architecture after injury requires rebuilding its fibroelastic extracellular matrix scaffold. Konkimalla et al. establish that regenerative cell states (RCSs) of both epithelial and mesenchymal origin are functionally linked and indispensable for this process. Experimental ablation of RCSs causes organ degeneration, whereas their induction causes organ fibrosis.
-
Epitope base editing: Non-malignant stem cells are going undercover Cell Stem Cell (IF 23.9) Pub Date : 2023-11-02 Shayan Saniei, Elvin Wagenblast
Engineered hematopoietic stem cells can be shielded from targeted immunotherapy. Recently published in Nature, Casirati et al. utilized single-base editing of epitopes implicated in acute myeloid leukemia and healthy hematopoiesis to alter their antibody and chimeric antigen receptor (CAR) T recognition while preserving their ligand binding and enzymatic function.
-
Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity Cell Stem Cell (IF 23.9) Pub Date : 2023-11-02 Alessia Gravina, Grigol Tediashvili, Yueting Zheng, Kumiko A. Iwabuchi, Sara M. Peyrot, Susan Z. Roodsari, Lauren Gargiulo, Shin Kaneko, Mitsujiro Osawa, Sonja Schrepfer, Tobias Deuse
-
Decoding aging-dependent regenerative decline across tissues at single-cell resolution Cell Stem Cell (IF 23.9) Pub Date : 2023-10-27 Yusheng Cai, Muzhao Xiong, Zijuan Xin, Chengyu Liu, Jie Ren, Xiying Yang, Jinghui Lei, Wei Li, Feifei Liu, Qun Chu, Yiyuan Zhang, Jian Yin, Yanxia Ye, Dingyi Liu, Yanling Fan, Shuhui Sun, Yaobin Jing, Qian Zhao, Liyun Zhao, Shanshan Che, Guang-Hui Liu
-
TGFB1 induces fetal reprogramming and enhances intestinal regeneration Cell Stem Cell (IF 23.9) Pub Date : 2023-10-20 Lei Chen, Xia Qiu, Abigail Dupre, Oscar Pellon-Cardenas, Xiaojiao Fan, Xiaoting Xu, Prateeksha Rout, Katherine D. Walton, Joseph Burclaff, Ruolan Zhang, Wenxin Fang, Rachel Ofer, Alexandra Logerfo, Kiranmayi Vemuri, Sheila Bandyopadhyay, Jianming Wang, Gaetan Barbet, Yan Wang, Nan Gao, Ansu O. Perekatt, Michael P. Verzi
-
Hematopoietic stem cells through the ages: A lifetime of adaptation to organismal demands Cell Stem Cell (IF 23.9) Pub Date : 2023-10-20 Monica Kasbekar, Carl A. Mitchell, Melissa A. Proven, Emmanuelle Passegué
Hematopoietic stem cells (HSCs), which govern the production of all blood lineages, transition through a series of functional states characterized by expansion during fetal development, functional quiescence in adulthood, and decline upon aging. We describe central features of HSC regulation during ontogeny to contextualize how adaptive responses over the life of the organism ultimately form the basis
-
SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation Cell Stem Cell (IF 23.9) Pub Date : 2023-10-19 Chun-Wei Chen, Linda Zhang, Ravi Dutta, Abhishek Niroula, Peter G. Miller, Christopher J. Gibson, Alexander G. Bick, Jaime M. Reyes, Yi-Tang Lee, Ayala Tovy, Tianpeng Gu, Sarah Waldvogel, Yi-Hung Chen, Bryan J. Venters, Pierre-Olivier Estève, Sriharsa Pradhan, Michael-Christopher Keogh, Pradeep Natarajan, Koichi Takahashi, Adam S. Sperling, Margaret A. Goodell
-
Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis Cell Stem Cell (IF 23.9) Pub Date : 2023-10-19 Li Ma, Qing Chang, Fei Pei, Mengmeng Liu, Wei Zhang, Young-Kwon Hong, Yang Chai, Jian-Fu Chen
-
Epigenetic regulation of early human embryo development Cell Stem Cell (IF 23.9) Pub Date : 2023-10-18 Amy L. Wilkinson, Irene Zorzan, Peter J. Rugg-Gunn
Studies of mammalian development have advanced our understanding of the genetic, epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered new insights into the unique aspects of human embryogenesis. Recent studies have now produced the first epigenetic maps of early human embryogenesis, stimulating new ideas about epigenetic reprogramming, cell fate control, and the potential
-
Stem cell mutations, associated cancer risk, and consequences for regenerative medicine Cell Stem Cell (IF 23.9) Pub Date : 2023-10-12 Lucca L.M. Derks, Ruben van Boxtel
Mutation accumulation in stem cells has been associated with cancer risk. However, the presence of numerous mutant clones in healthy tissues has raised the question of what limits cancer initiation. Here, we review recent developments in characterizing mutation accumulation in healthy tissues and compare mutation rates in stem cells during development and adult life with corresponding cancer risk.
-
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation Cell Stem Cell (IF 23.9) Pub Date : 2023-10-12 Yaobin Jing, Xiaoyu Jiang, Qianzhao Ji, Zeming Wu, Wei Wang, Zunpeng Liu, Pedro Guillen-Garcia, Concepcion Rodriguez Esteban, Pradeep Reddy, Steve Horvath, Jingyi Li, Lingling Geng, Qinchao Hu, Si Wang, Juan Carlos Izpisua Belmonte, Jie Ren, Weiqi Zhang, Jing Qu, Guang-Hui Liu
-
Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson’s disease, STEM-PD Cell Stem Cell (IF 23.9) Pub Date : 2023-10-05 Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, Nina Rogelius, Hjálmar Bjartmarz, , Petter Storm, Alessandro Fiorenzano, Andrew F. Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso, Bengt Mattsson, Anne M. Landau, Andreas N. Glud, Jens C. Sørensen, Thea P. Lillethorup, Mark Lowdell, Carla Carvalho, Malin Parmar
-
Fishing for “complements” with vascular organoid models of microvascular disease Cell Stem Cell (IF 23.9) Pub Date : 2023-10-05 Sean X. Gu, Timur O. Yarovinsky, John Hwa
In this issue of Cell Stem Cell, Kawakami et al. develop a SARS-CoV-2 infection-competent, progenitor-derived, human vascular organoid model and uncover a role for complement factor D (CFD) in mediating microvascular immunothrombosis. This model may be applied to conditions where microvascular disease plays a major pathogenic role.