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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity Immunity (IF 25.5) Pub Date : 2025-05-12 Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A. Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K. Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K. Burks, Qing Zhang, Li Ma, Jianjun Gao, Chunru Lin
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Computationally designed proteins mimic antibody immune evasion in viral evolution Immunity (IF 25.5) Pub Date : 2025-05-08 Noor Youssef, Sarah Gurev, Fadi Ghantous, Kelly P. Brock, Javier A. Jaimes, Nicole N. Thadani, Ann Dauphin, Amy C. Sherman, Leonid Yurkovetskiy, Daria Soto, Ralph Estanboulieh, Ben Kotzen, Pascal Notin, Aaron W. Kollasch, Alexander A. Cohen, Sandra E. Dross, Jesse Erasmus, Deborah H. Fuller, Pamela J. Bjorkman, Jacob E. Lemieux, Debora S. Marks
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Vaccination of nonhuman primates elicits a broadly neutralizing antibody lineage targeting a quaternary epitope on the HIV-1 Env trimer Immunity (IF 25.5) Pub Date : 2025-05-07 Fabian-Alexander Schleich, Shridhar Bale, Javier Guenaga, Gabriel Ozorowski, Monika Àdori, Xiaohe Lin, Xaquin Castro Dopico, Richard Wilson, Mark Chernyshev, Alma Teresia Cotgreave, Marco Mandolesi, Jocelyn Cluff, Esmeralda D. Doyle, Leigh M. Sewall, Wen-Hsin Lee, Shiyu Zhang, Sijy O’Dell, Brandon S. Healy, Deuk Lim, Vanessa R. Lewis, Richard T. Wyatt
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Somatic hypermutation unlocks antibody specificities beyond the primary repertoire Immunity (IF 25.5) Pub Date : 2025-05-07 Teng Zuo, Avneesh Gautam, Shahab Saghaei, Sweta N. Khobragade, Rahaman Ahmed, Azadeh Mahdavinia, Mehrdad Zarghami, Gaspar A. Pacheco, Kenneth Green, Meghan Travers, Nicholas Garcia, Zahra Allahyari, Vishal Rao, Sachin Kumar, Robert Novak, Joyce K. Hwang, Duane R. Wesemann
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Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent γδ TCR activation Immunity (IF 25.5) Pub Date : 2025-05-06 Yuwei Zhu, Wenbo Gao, Jianlin Zheng, Ye Bai, Xinyu Tian, Tengjin Huang, Zebin Lu, De Dong, Anqi Zhang, Changyou Guo, Zhiwei Huang
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Microglia transcriptional states and their functional significance: Context drives diversity Immunity (IF 25.5) Pub Date : 2025-05-06 Constanze Depp, Jordan L. Doman, Maximilian Hingerl, Judy Xia, Beth Stevens
In the brain, microglia are continuously exposed to a dynamic microenvironment throughout life, requiring them to adapt accordingly to specific developmental or disease-related demands. The advent of single-cell sequencing technologies has revealed the diversity of microglial transcriptional states. In this review, we explore the various contexts that drive transcriptional diversity in microglia and
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Complex neural-immune interactions shape glioma immunotherapy Immunity (IF 25.5) Pub Date : 2025-05-04 Kun-Wei Song, Michael Lim, Michelle Monje
Rich neural-immune interactions in the central nervous system (CNS) shape its function and create a unique immunological microenvironment for immunotherapy in CNS malignancies. Far from the now-debunked concept of CNS “immune privilege,” it is now understood that unique immunological niches and constant immune surveillance of the brain contribute in multifaceted ways to brain health and robustly influence
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Border-associated macrophages as gatekeepers of brain homeostasis and immunity Immunity (IF 25.5) Pub Date : 2025-05-04 Mónica Vara-Pérez, Kiavash Movahedi
The brain’s border tissues serve as essential hubs for neuroimmune regulation and the trafficking of biomaterials to and from the brain. These complex tissues—including the meninges, perivascular spaces, choroid plexus, and circumventricular organs—balance the brain’s need for immune privilege with immune surveillance and blood-brain communication. Macrophages are integral components of these tissues
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Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms Immunity (IF 25.5) Pub Date : 2025-05-04 Oleg Butovsky, Neta Rosenzweig
Alzheimer’s disease (AD) and age-related macular degeneration (AMD) represent the leading causes of dementia and vision impairment in the elderly, respectively. The retina is an extension of the brain, yet these two central nervous system (CNS) compartments are often studied separately. Despite affecting cognition vs. vision, AD and AMD share neuroinflammatory pathways. By comparing these diseases
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The sensory neuroimmune frontier Immunity (IF 25.5) Pub Date : 2025-05-04 Brian S. Kim, David Artis
Sensing and recognition are key properties of both the immune and nervous systems. In the immune system, pattern recognition or antigen-specific receptors represent classic motifs in innate and adaptive immunity, respectively. In the nervous system, there is a major anatomic division between how we sense stimuli from within the body (vagal sensory nervous system) and the outside world (somatosensory
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Glymphatics and meningeal lymphatics unlock the brain-immune code Immunity (IF 25.5) Pub Date : 2025-05-04 Min Woo Kim, Jonathan Kipnis
The central nervous system (CNS) was once perceived as entirely shielded from the immune system, protected behind the blood-brain barrier and thought to lack lymphatic drainage. However, recent evidence has challenged many dogmas in neuroimmunology. Indeed, by means of glymphatics, brain-derived “waste” from deep within the CNS mobilizes toward immunologically active brain borders, where meningeal
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Role of specialized sensory neuron subtypes in modulating peripheral immune responses Immunity (IF 25.5) Pub Date : 2025-05-04 Théo Crosson, Ninon Bretaud, Sophie Ugolini
The immune and sensory nervous systems detect diverse threats, from tissue damage to infection, and coordinate protective responses to restore homeostasis. Like immune cells, sensory neurons exhibit remarkable heterogeneity, with advanced genetic models revealing that distinct subsets differentially regulate immune responses. Here, we review how various immune signals engage distinct subtypes of sensory
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Niche-specific therapeutic targeting of myeloid cells in the central nervous system Immunity (IF 25.5) Pub Date : 2025-05-04 Maximilian Frosch, Marco Prinz
The central nervous system (CNS) can be subdivided into distinct anatomical and functional compartments, including the parenchyma, perivascular space, leptomeninges, and dura mater, etc. Each compartment hosts distinct immune cell populations, such as monocytes and diverse macrophages, which play critical roles in local tissue homeostasis and regional disease pathogenesis. Advances in single-cell technologies
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Microglial and TREM2 dialogues in the developing brain Immunity (IF 25.5) Pub Date : 2025-05-04 Raffaella Morini, Erica Tagliatti, Matteo Bizzotto, Michela Matteoli
From the migration of precursor cells to the refinement of neural circuits, the immune system plays a critical role in the development of the central nervous system. As the brain resident macrophages, microglia are integral to these processes, influencing key developmental stages and contributing to circuit remodeling. Recent years have brought a wealth of new insights into how microglia regulate key
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Inflammasome signaling in astrocytes modulates hippocampal plasticity Immunity (IF 25.5) Pub Date : 2025-05-02 Kristine E. Zengeler, Ava Hollis, Tyler C.J. Deutsch, Joshua D. Samuels, Hannah Ennerfelt, Katelyn A. Moore, Eric J. Steacy, Vikram Sabapathy, Rahul Sharma, Manoj K. Patel, John R. Lukens
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A hierarchy of intestinal antigens instructs the CD4+ T cell receptor repertoire Immunity (IF 25.5) Pub Date : 2025-05-02 Jaeu Yi, Jisun Jung, David Horton, Patricia Hsieh, Yangqing Peng, Sean J. Wang, Rodney Newberry, Aaron C. Ericsson, Kwang Soon Kim, Andrew L. Kau, Chyi-Song Hsieh
Intestinal CD4+ T cells that are specific for self-, diet-, or commensal-derived antigens are critical for host tolerance but must also be tightly regulated to prevent aberrant activation and conditions like inflammatory bowel disease (IBD). However, it is unclear how the antigen source and location dictate the intestinal TCR repertoire. Here, we hierarchically classified self-, diet-, or microbiota-dependent
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Interleukin-34-dependent perivascular macrophages promote vascular function in the brain Immunity (IF 25.5) Pub Date : 2025-05-01 Hannah Van Hove, Chaim Glück, Wiebke Mildenberger, Ekaterina Petrova, Upasana Maheshwari, Philipp Häne, Victor Kreiner, Mitchell Bijnen, Caroline Mussak, Sebastian G. Utz, Jeanne Droux, Florian Ingelfinger, Christian Ashworth, Sebastian A. Stifter, Elsa Roussel, Iva Lelios, Marijne Vermeer, Sheng-Fu Huang, Quanyu Zhou, Zhenyue Chen, Charlotte Calvet, Soline Bourgeois, Johanna Schaffenrath, Daniel Razansky
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Monocytes can efficiently replace all brain macrophages and fetal liver monocytes can generate bona fide SALL1+ microglia Immunity (IF 25.5) Pub Date : 2025-04-30 Jonathan Bastos, Carleigh O’Brien, Mónica Vara-Pérez, Myrthe Mampay, Lynn van Olst, Liam Barry-Carroll, Daliya Kancheva, Sophia Leduc, Ayla Line Lievens, Leen Ali, Vladislav Vlasov, Laura Meysman, Hadis Shakeri, Ria Roelandt, Hannah Van Hove, Karen De Vlaminck, Isabelle Scheyltjens, Fazeela Yaqoob, Sonia I. Lombroso, Maria Breugelmans, Gilles Faron, Diego Gomez-Nicola, David Gate, F. Chris Bennett
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Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease Immunity (IF 25.5) Pub Date : 2025-04-30 William H. Aisenberg, Carleigh A. O’Brien, Madison Sangster, Fazeela Yaqoob, Yuanchao Zhang, Brian Temsamrit, Searlait Thom, Luca Gosse, Sai Chaluvadi, Bilal Elfayomi, Gavin Lee, Vidhur Polam, Eli M. Levitt, Gary Liu, Sonia I. Lombroso, Kelsey M. Nemec, Gavin Clowry, Cassaundra Nieves, Priyanka Rawat, Emily Church, Daniel Martinez, Clarissa Shoffler, Daliya Kancheva, Christopher Petucci, Deanne Taylor
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IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis Immunity (IF 25.5) Pub Date : 2025-04-29 Seung Hyeon Kim, Zachary White, Anastasiia Gainullina, Soeun Kang, Jiseon Kim, Joseph R. Dominguez, Yeonwoo Choi, Ivan Cabrera, Madison Plaster, Michihiro Takahama, Rafael S. Czepielewski, Jinki Yeom, Matthias Gunzer, Nissim Hay, Odile David, Nicolas Chevrier, Teruyuki Sano, Ki-Wook Kim
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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection Immunity (IF 25.5) Pub Date : 2025-04-25 Jun Xiao, Weiyun Li, Xin Zheng, Linlin Qi, Hui Wang, Chi Zhang, Xiaopeng Wan, Yuxiao Zheng, Ruiyue Zhong, Xin Zhou, Yao Lu, Zhiqi Li, Ying Qiu, Chang Liu, Fang Zhang, Yanbo Zhang, Xiaoyan Xu, Zhongzhou Yang, Hualan Chen, Qiwei Zhai, Hongyan Wang
(Immunity 52, 109–122.e1–e6; January 14, 2020)
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B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8+ T cell function Immunity (IF 25.5) Pub Date : 2025-04-25 Nastaran Fazel Modares, Liam D. Hendrikse, Logan K. Smith, Michael St. Paul, Jillian Haight, Ping Luo, Shaofeng Liu, Jerome Fortin, Frances K. Tong, Andrew C. Wakeham, Soode Moghadas Jafari, Chunxing Zheng, Mackenzie Buckland, Robert Flick, Jennifer Silvester, Thorsten Berger, Troy Ketela, Simone Helke, Erica Foffi, Raheleh Niavarani, Ryan Mcwilliam, Mary E. Saunders, Isabelle Colonna, Bruna Araujo
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Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling Immunity (IF 25.5) Pub Date : 2025-04-25 Stephen T. Yeung, Payal Damani-Yokota, Sara A. Thannickal, Eric Bartnicki, Eduardo D. Bernier, Clea R. Barnett, Camille Khairallah, Ralf Duerr, Maria G. Noval, Leopoldo N. Segal, Kenneth A. Stapleford, Kamal M. Khanna
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Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution Immunity (IF 25.5) Pub Date : 2025-04-24 Kami Pekayvaz, Badr Kilani, Markus Joppich, Luke Eivers, Sophia Brambs, Viktoria Knottenberg, Sezer Akgöl, Keyang Yue, Lukas Li, Alejandro Martinez-Navarro, Rainer Kaiser, Nina Meißner, Heiko Schulz, Larissa Belz, Anastassia Akhalkatsi, Sven Stockhausen, Tonina T. Mueller, Simon Millonig, Lea Hartelt, Christoph Gold, Aleksandar Janjic, Vivien Polewka, Franziska Wendler, Augustin Droste zu Senden, Anna
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Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies Immunity (IF 25.5) Pub Date : 2025-04-24 Felipe Galvez-Cancino, Mariela Navarrete, Gordon Beattie, Simone Puccio, Enrique Conde-Gallastegi, Kane Foster, Yasmin Morris, Teerapon Sahwangarrom, Despoina Karagianni, Jiali Liu, Alvin J.X. Lee, Dimitrios A. Garyfallos, Alexander P. Simpson, Gerasimos-Theodoros Mastrokalos, Francesco Nannini, Cristobal Costoya, Varshaa Anantharam, Beatrice Claudia Cianciotti, Leanne Bradley, Claudia Garcia-Diaz
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Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis Immunity (IF 25.5) Pub Date : 2025-04-14 Le Xiong, Shanti Diwakarla, Roxanne Chatzis, Olivia Artaiz, Matthew Macowan, Shengbo Zhang, Alexandra Garnham, Pooranee K. Morgan, Natalie A. Mellett, Peter J. Meikle, Graeme I. Lancaster, Benjamin J. Marsland, Stephen L. Nutt, Cyril Seillet
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A. faecalis induces intestinal T helper 17 cells by promoting E3 ubiquitin ligase Trim21-mediated E3 ubiquitin ligase Fbxw7 degradation Immunity (IF 25.5) Pub Date : 2025-04-10 Yingying Shen, Zeyu Ma, Hanliang Wang, Yinghu Chen, Yue Fang, Lionel Apetoh, Gensheng Zhang, Fenglian He, Shaofang Xie, Jufeng Guo, Shuaikang Cao, Hai Li, Qingqing Wang, Jianli Wang, Junjie Xu, Zhijian Cai
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Michael Cancro (1949–2025) Immunity (IF 25.5) Pub Date : 2025-04-08 Mark J. Shlomchik, David Allman
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2-5A is an immunotransmitter that fuels RNase L immunity Immunity (IF 25.5) Pub Date : 2025-04-08 Songnan Wang, Lingyin Li
cGAS-cGAMP-STING and OAS-2-5A-RNase L are evolutionarily convergent innate immune pathways. cGAMP acts as an immunotransmitter; what about 2-5A? In this issue of Immunity, Huai et al. map the transfer of 2-5A between cells, establishing it as a bona fide immunotransmitter.
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IL-9 and ZBTB18 are germinal center memory makers Immunity (IF 25.5) Pub Date : 2025-04-08 Erica L. Stewart, Deborah L. Burnett
Long-lived memory B cells developing from germinal centers (GCs) are important contributors to protective immunity. In this issue of Immunity, Luo et al. report that during primary responses, T cell-derived interleukin-9 potentiates differentiation of GC memory precursors into functional memory B cells in a manner dependent on the transcriptional regulator ZBTB18.
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More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade Immunity (IF 25.5) Pub Date : 2025-04-08 Daniel H. Shu, Mark Yarchoan
The combination of antiangiogenic and immune checkpoint inhibitor (ICI) treatment is active in solid tumors, but the mechanism of response remains unclear. In this issue of Immunity, Benmebarek et al. show that anti-vascular endothelial growth factor enhances ICI by reprogramming regulatory T cells into a fragile state.
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Glia get RIPped in ALS Immunity (IF 25.5) Pub Date : 2025-04-08 Alexis M. Johnson, John R. Lukens
While neuroinflammatory responses driven by microglia and astrocytes have been extensively linked to neurodegenerative disease progression in amyotrophic lateral sclerosis (ALS), the specific pathways that coordinate glial cell-dependent neuroinflammation in ALS remain poorly defined. In this issue of Immunity, Zelic et al.1 identified RIPK1 as a pivotal regulator of glial cell-driven neuroinflammation
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T cells with a taste for tissue remodeling Immunity (IF 25.5) Pub Date : 2025-04-08 Greet Verstichel, Hilde Cheroutre
Specialized T cells can support tissue remodeling, but how T cells contribute to mammary gland remodeling during pregnancy is not fully understood. In a recent Cell issue, Corral et al. demonstrate that self-sensing T cells migrate to the mammary gland where they optimize milk production.
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway Immunity (IF 25.5) Pub Date : 2025-04-08 Ping Lai, Lei Liu, Nicolò Bancaro, Martina Troiani, Bianca Calì, Yuxin Li, Jingjing Chen, Prafull Kumar Singh, Rydell Alvarez Arzola, Giuseppe Attanasio, Nicolò Pernigoni, Emiliano Pasquini, Simone Mosole, Andrea Rinaldi, Jacopo Sgrignani, Shi Qiu, Pan Song, Yingrui Li, Maria Andrea Desbats, Azucena Rendón Ángel, Ricardo Pereira Mestre, Andrea Cavalli, Lucio Barile, Johann de Bono, Andrea Alimonti
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Diverse priming outcomes under conditions of very rare precursor B cells Immunity (IF 25.5) Pub Date : 2025-03-31 Patrick J. Madden, Ester Marina-Zárate, Kristen A. Rodrigues, Jon M. Steichen, Monolina Shil, Kaiyuan Ni, Katarzyna Kaczmarek Michaels, Laura Maiorino, Amit A. Upadhyay, Swati Saha, Arpan Pradhan, Oleksandr Kalyuzhiny, Alessia Liguori, Paul G. Lopez, Ivy Phung, Claudia Flynn, Amelia Zhou, Mariane B. Melo, Ashley Lemnios, Nicole Phelps, Erik Georgeson, Nushin Alavi, Michael Kubitz, Danny Lu, Saman Eskandarzadeh
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Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity Immunity (IF 25.5) Pub Date : 2025-03-31 Motonao Osaki, Shimon Sakaguchi
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Immunological drivers of zoonotic virus emergence, evolution, and endemicity Immunity (IF 25.5) Pub Date : 2025-03-31 Jyothi N. Purushotham, Holly L. Lutz, Edyth Parker, Kristian G. Andersen
The disruption of natural ecosystems caused by climate change and human activity is amplifying the risk of zoonotic spillover, presenting a growing global health threat. In the past two decades, the emergence of multiple zoonotic viruses has exposed critical gaps in our ability to predict epidemic trajectories and implement effective interventions. RNA viruses, in particular, are challenging to control
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Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer Immunity (IF 25.5) Pub Date : 2025-03-28 Liqun Yu, Keziah Liebenberg, Yichao Shen, Fengshuo Liu, Zhan Xu, Xiaoxin Hao, Ling Wu, Weijie Zhang, Hilda L. Chan, Bo Wei, Philip L. Lorenzi, Yang Gao, Igor Bado, Luis Becerra-Dominguez, Charlotte Helena Rivas, Sergio Aguirre, Bradley C. Pingel, Yi-Hsuan Wu, Yunfeng Ding, Jun Liu, David G. Edwards, Livia S. Eberlin, Xiang H.-F. Zhang
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Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract Immunity (IF 25.5) Pub Date : 2025-03-25 Alexander J. Nelson, Bruna K. Tatematsu, Jordan R. Beach, Dorothy K. Sojka, Yee Ling Wu
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Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors Immunity (IF 25.5) Pub Date : 2025-03-25 François-Xavier Mauvais, Yamina Hamel, Aymeric Silvin, Kevin Mulder, Kai Hildner, Ramazan Akyol, Marc Dalod, Despoina Koumantou, Loredana Saveanu, Meriem Garfa, Nicolas Cagnard, Barbara Bertocci, Florent Ginhoux, Peter van Endert
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The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2 Immunity (IF 25.5) Pub Date : 2025-03-25 Xiaodan Hu, Jianchen Wu, Lu Shi, Folin Wang, Kezhang He, Pengcheng Tan, Yanyan Hu, Yuanyuan Yang, Dan Wang, Tianhua Ma, Sheng Ding
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Long-lasting B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutinins Immunity (IF 25.5) Pub Date : 2025-03-24 Jenna J. Guthmiller, Linda Yu-Ling Lan, Lei Li, Yanbin Fu, Sean A. Nelson, Carole Henry, Christopher T. Stamper, Henry A. Utset, Alec W. Freyn, Julianna Han, Olivia Stovicek, Jiaolong Wang, Nai-Ying Zheng, Min Huang, Haley L. Dugan, Micah E. Tepora, Xueyong Zhu, Yao-Qing Chen, Anna-Karin E. Palm, Dustin G. Shaw, Madhumathi Loganathan, Benjamin F. Francis, Jiayi Sun, Jordan Chervin, Chloe Troxell, Philip
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Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis Immunity (IF 25.5) Pub Date : 2025-03-24 Matija Zelic, Anna Blazier, Fabrizio Pontarelli, Michael LaMorte, Jeremy Huang, Ozge E. Tasdemir-Yilmaz, Yi Ren, Sean K. Ryan, Cynthia Shapiro, Caroline Morel, Pavithra Krishnaswami, Mikhail Levit, Disha Sood, Yao Chen, Joseph Gans, Xinyan Tang, Jennifer Hsiao-Nakamoto, Fen Huang, Bailin Zhang, James D. Berry, Dinesh S. Bangari, Giorgio Gaglia, Dimitry Ofengeim, Timothy R. Hammond
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Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression Immunity (IF 25.5) Pub Date : 2025-03-20 Isidoro Cobo, Jessica Murillo-Saich, Mohnish Alishala, Stephen Calderon, Roxana Coras, Benjamin Hemming, Faith Inkum, Fiorella Rosas, Riku Takei, Nathan Spann, Thomas A. Prohaska, Paulo V.G. Alabarse, Se-Jin Jeong, Christian K. Nickl, Anyan Cheng, Benjamin Li, Andrea Vogel, Thomas Weichhart, José J. Fuster, Thomas Le, Tara R. Bradstreet, Ashlee M. Webber, Brian T. Edelson, Babak Razani, Benjamin L
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The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock Immunity (IF 25.5) Pub Date : 2025-03-19 Hitesh Arora, Sara Morgan Wilcox, Laura Alexandra Johnson, Lonna Munro, Brett Alexander Eyford, Cheryl Gurine Pfeifer, Ian Welch, Wilfred Arthur Jefferies
(Immunity 50, 418–431.e1–e6; February 19, 2019)
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Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors Immunity (IF 25.5) Pub Date : 2025-03-18 Leire Bejarano, Joao Lourenco, Annamaria Kauzlaric, Eleni Lamprou, Catia F. Costa, Sabine Galland, Roeltje R. Maas, Paola Guerrero Aruffo, Nadine Fournier, Jean-Philippe Brouland, Andreas F. Hottinger, Roy T. Daniel, Monika E. Hegi, Johanna A. Joyce
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An interleukin-9-ZBTB18 axis promotes germinal center development of memory B cells Immunity (IF 25.5) Pub Date : 2025-03-18 Xiaocui Luo, Xiaoxiao Hou, Yifeng Wang, Ye Li, Shangcheng Yu, Hai Qi
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Anti-vascular endothelial growth factor treatment potentiates immune checkpoint blockade through a BAFF- and IL-12-dependent reprogramming of the TME Immunity (IF 25.5) Pub Date : 2025-03-14 Mohamed-Reda Benmebarek, Cihan Oguz, Matthias Seifert, Benjamin Ruf, Yuta Myojin, Kylynda C. Bauer, Patrick Huang, Chi Ma, Marina Villamor-Payà, Francisco Rodriguez-Matos, Marlaine Soliman, Rajiv Trehan, Cecilia Monge, Changqing Xie, David E. Kleiner, Bradford J. Wood, Elliot B. Levy, Anuradha Budhu, Noemi Kedei, Christian T. Mayer, Xin Wei Wang, Justin Lack, William Telford, Firouzeh Korangy, Tim
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NK resident memory cells arise from NK cells that accumulate in tissues independently of persistent local infection Immunity (IF 25.5) Pub Date : 2025-03-11 Iona S. Schuster, Matthew E. Wikstrom, Christopher E. Andoniou, Mariapia A. Degli-Esposti
Section snippets Main textA recent study by Gasteiger and colleagues1 described a population of circulating natural killer (NK) cells that are recruited and retained in the skin for several weeks following local viral (vaccinia virus) and bacterial (Staphylococcus aureus) infections. These cells, which the authors refer to as tissue resident (tr)NK cells, exhibit increased production of effector molecules
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Differentiation of tissue-resident NK cells: Why origin and context matter Immunity (IF 25.5) Pub Date : 2025-03-11 Christin Friedrich, Tommaso Torcellan, Georg Gasteiger
Section snippets Main textIn their letter to Immunity, Degli-Esposti and colleagues1 discuss the potential origins of tissue-resident natural killer (trNK) cells and the inflammatory contexts enabling their differentiation. These largely unresolved issues are relevant for NK-based cellular therapies and our understanding of tissue immunity. Here, we examine key complementarities and differences between
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The CREscendoing promise of HDAC targeting to limit atherosclerosis Immunity (IF 25.5) Pub Date : 2025-03-11 Máté G. Kiss, Christoph J. Binder
The factors that modulate the inflammatory response in atherosclerosis are not well defined. In this issue of Immunity, Asare et al. examine the impact of a cis-regulatory element (CRE) that controls expression of HDAC9 and find that HDAC9-mediated deacetylation of NLRP3 might be the mechanism by which genetic variants in this conserved CRE influence the inflammation associated with human atherosclerosis
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SPeak to the heart Immunity (IF 25.5) Pub Date : 2025-03-11 Min Zhang, Zhen Zhang
Neuroimmune regulation modulates responses to cardiovascular stress and injury. In this issue of Immunity, Perrotta et al. delineate a heart-brain-spleen axis that induces adaptive cardiac remodeling in response to pressure overload, highlighting a SPeak mechanism (spleen-derived PlGF efflux activates cardiac macrophages).
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RIPK3: The Deadpool of neuronal cell death proteins? Immunity (IF 25.5) Pub Date : 2025-03-11 Clayton W. Winkler, Karin E. Peterson
Receptor interaction kinase 3 (RIPK3) is a key mediator of necroptosis, initiating programmed cell death with mercenary efficiency in multiple neurodegenerative diseases. However, in this issue of Immunity, Estevez et al. demonstrate that RIPK3, like the character Deadpool, exists in duality and can also be a force for good by preventing excitotoxic neuronal death during orthoflavivirus encephalitis
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Parts and ICRAFTs: Finding new immunotherapy targets Immunity (IF 25.5) Pub Date : 2025-03-11 Kevin Bi, Kathleen B. Yates
CRISPR screens are widely utilized to identify genes that regulate immune function or mediate sensitivity of cancer cells to immune attack. In this issue of Immunity, Zeng et al. present a computational framework for uncovering gene targets with dual function in both cancer and immune cells and nominate TNFAIP3 as a synergistic target whose ablation strongly elicits an antitumor response.
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Immo-bile-izing CD8+ T cell anti-tumor immunity Immunity (IF 25.5) Pub Date : 2025-03-11 Scott A. Read, Golo Ahlenstiel
Hepatocellular carcinoma is poorly responsive to immune checkpoint blockade. In a recent issue of Science, Varanasi et al. reveal how bile acids dampen anti-tumor CD8+ T cell responses in the liver, contributing to cancer progression and poor immunotherapy outcomes.
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Lactate: A key regulator of the immune response Immunity (IF 25.5) Pub Date : 2025-03-11 Alba Llibre, Salih Kucuk, Atrayee Gope, Michelangelo Certo, Claudio Mauro
Lactate, the end product of both anaerobic and aerobic glycolysis in proliferating and growing cells—with the latter process known as the Warburg effect—is historically considered a mere waste product of cell and tissue metabolism. However, research over the past ten years has unveiled multifaceted functions of lactate that critically shape and impact cellular biology. Beyond serving as a fuel source
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Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells Immunity (IF 25.5) Pub Date : 2025-02-28 Adriana M. Mujal, Mark Owyong, Endi K. Santosa, John C. Sauter, Simon Grassmann, Anna-Marie Pedde, Philippa Meiser, Claire K. Wingert, Marine Pujol, Veit R. Buchholz, Colleen M. Lau, Jan P. Böttcher, Joseph C. Sun
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Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis Immunity (IF 25.5) Pub Date : 2025-02-28 Yuxin Zhang, Yuchao Jing, Juan He, Rui Dong, Tongyang Li, Fang Li, Xiaoqing Zheng, Gaoyu Liu, Ran Jia, Jin Xu, Fan Wu, Chunhong Jia, Jin Song, Lijuan Zhang, Pan Zhou, Haitao Wang, Zhi Yao, Qiang Liu, Ying Yu, Jie Zhou
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Antigenic drift expands influenza viral escape pathways from recalled humoral immunity Immunity (IF 25.5) Pub Date : 2025-02-28 Daniel P. Maurer, Mya Vu, Aaron G. Schmidt
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells Immunity (IF 25.5) Pub Date : 2025-02-28 Ce Luo, Rui Zhang, Rui Guo, Lijian Wu, Teng Xue, Yufeng He, Yiteng Jin, Yanping Zhao, Zongxu Zhang, Peng Zhang, Sitong Ye, Xiaohong Li, Dian Li, Wubing Zhang, Chenfei Wang, Luhua Lai, Qiang Pan-Hammarström, Kai W. Wucherpfennig, Zhidong Gao, Deng Pan, Zexian Zeng