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SMURF1: A promising target for colon cancer therapy. Protein Cell (IF 13.6) Pub Date : 2024-09-27 Xiufang Xiong,Yongchao Zhao,Yi Sun
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PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation mediated gene expression. Protein Cell (IF 13.6) Pub Date : 2024-09-23 Zetan Jiang,Nanchi Xiong,Ronghui Yan,Shi-Ting Li,Haiying Liu,Qiankun Mao,Yuchen Sun,Shengqi Shen,Ling Ye,Ping Gao,Pinggen Zhang,Weidong Jia,Huafeng Zhang
Deactivation of the mitochondrial pyruvate dehydrogenase complex (PDC) is important for the metabolic switching of cancer cell from oxidative phosphorylation to aerobic glycolysis. Studies examining PDC activity regulation have mainly focused on the phosphorylation of pyruvate dehydrogenase (PDH, E1), leaving other post-translational modifications (PTMs) largely unexplored. Here, we demonstrate that
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CORD: The chordata olfactory receptor database. Protein Cell (IF 13.6) Pub Date : 2024-09-20 Wei Han,Siyu Bao,Jintao Liu,Yiran Wu,Liting Zeng,Tao Zhang,Ningmeng Chen,Kai Yao,Shunguo Fan,Aiping Huang,Yuanyuan Feng,Guiquan Zhang,Ruiyi Zhang,Hongjin Zhu,Tian Hua,Zhijie Liu,Lina Cao,Xingxu Huang,Suwen Zhao
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ER membrane remodeling by targeting RTN4 induces pyroptosis to facilitate antitumor immune. Protein Cell (IF 13.6) Pub Date : 2024-09-10 Mei-Mei Zhao,Ting-Ting Ren,Jing-Kang Wang,Lu Yao,Ting-Ting Liu,Ji-Chao Zhang,Yang Liu,Lan Yuan,Dan Liu,Jiu-Hui Xu,Peng-Fei Tu,Xiao-Dong Tang,Ke-Wu Zeng
Pyroptosis is an identified programmed cell death that has been highly linked to endoplasmic reticulum (ER) dynamics. However, the crucial proteins for modulating dynamic ER membrane curvature change that trigger pyroptosis are currently not well understood. In this study, a biotin-labeled chemical probe of potent pyroptosis inducer α-mangostin (α-MG) was synthesized. Through protein microarray analysis
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RADICAL: a rationally designed ion channel activated by ligand for chemogenetics. Protein Cell (IF 13.6) Pub Date : 2024-09-03 Heng Zhang,Zhiwei Zheng,Xiaoying Chen,Lizhen Xu,Chen Guo,Jiawei Wang,Yihui Cui,Fan Yang
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Lcn2 secreted by macrophages through NLRP3 signaling pathway induced severe pneumonia. Protein Cell (IF 13.6) Pub Date : 2024-08-24 Mingya Liu,Feifei Qi,Jue Wang,Fengdi Li,Qi Lv,Ran Deng,Xujian Liang,Shasha Zhou,Pin Yu,Yanfeng Xu,Yaqing Zhang,Yiwei Yan,Ming Liu,Shuyue Li,Guocui Mou,Linlin Bao
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Molecular architecture of mammalian pyruvate dehydrogenase complex. Protein Cell (IF 13.6) Pub Date : 2024-08-24 Maofei Chen,Yutong Song,Sensen Zhang,Yitang Zhang,Xudong Chen,Minghui Zhang,Meng Han,Xin Gao,Sai Li,Maojun Yang
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Adenosine-to-Inosine RNA editing in cancer: molecular mechanisms and downstream targets. Protein Cell (IF 13.6) Pub Date : 2024-08-10 Hao Cheng,Jun Yu,Chi Chun Wong
Adenosine-to-Inosine (A-to-I), one of the most prevalent RNA modifications, has recently garnered significant attention. The A-to-I modification actively contributes to biological and pathological processes by affecting the structure and function of various RNA molecules, including double stranded RNA, transfer RNA, microRNA, and viral RNA. Increasing evidence suggests that A-to-I plays a crucial role
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Advances in Gene and Cellular Therapeutic Approaches for Huntington's Disease. Protein Cell (IF 13.6) Pub Date : 2024-08-09 Xuejiao Piao,Dan Li,Hui Liu,Qing Guo,Yang Yu
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG trinucleotide repeats in the Huntingtin gene (HTT) located on chromosome 4. It is transmitted in an autosomal dominant manner and is characterized by motor dysfunction, cognitive decline, and emotional disturbances. To date, there are no curative treatments for HD have been developed; current
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Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens. Protein Cell (IF 13.6) Pub Date : 2024-08-01 Chao Yang,Longfeng Yao,Dan Chen,Changling Chen,Wenbo Li,Hua Tong,Zihang Cheng,Yanling Yan,Long Lin,Jing Zhang,Anbing Shi
Endosomes are characterized by the presence of various phosphoinositides that are essential for defining the membrane properties. However, the interplay between endosomal phosphoinositides metabolism and innate immunity is yet to be fully understood. Here, our findings highlight the evolutionary continuity of RAB-10/Rab10's involvement in regulating innate immunity. Upon infection of C. elegans with
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Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model. Protein Cell (IF 13.6) Pub Date : 2024-07-27 Xin-Yu Cai,Xin-Tai Wang,Jing-Wen Guo,Fang-Xiao Xu,Kuang-Yi Ma,Zhao-Xiang Wang,Yue Zhao,Wei Xie,Martijn Schonewille,Chris De Zeeuw,Wei Chen,Ying Shen
The cerebellum is heavily connected with other brain regions, sub-serving not only motor but also non-motor functions. Genetic mutations leading to cerebellar dysfunction are associated with mental diseases, but cerebellar outputs have not been systematically studied in this context. Here, we present three dimensional distributions of 50,168 target neurons of cerebellar nuclei (CN) from wild-type mice
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Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging. Protein Cell (IF 13.6) Pub Date : 2024-07-20 Qinchao Hu,Bin Zhang,Yaobin Jing,Shuai Ma,Lei Hu,Jingyi Li,Yandong Zheng,Zijuan Xin,Jianmin Peng,Si Wang,Bin Cheng,Jing Qu,Weiqi Zhang,Guang-Hui Liu,Songlin Wang
Aging has a profound impact on the gingiva and significantly increases its susceptibility to periodontitis, a worldwide prevalent inflammatory disease. However, a systematic characterization and comprehensive understanding of the regulatory mechanism underlying gingival aging is still lacking. Here, we systematically dissected the phenotypic characteristics of gingiva during aging in primates and constructed
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DNA methylation clocks for estimating biological age in Chinese cohorts. Protein Cell (IF 13.6) Pub Date : 2024-07-20 Zikai Zheng,Jiaming Li,Tianzi Liu,Yanling Fan,Qiao-Cheng Zhai,Muzhao Xiong,Qiao-Ran Wang,Xiaoyan Sun,Qi-Wen Zheng,Shanshan Che,Beier Jiang,Quan Zheng,Cui Wang,Lixiao Liu,Jiale Ping,Si Wang,Dan-Dan Gao,Jinlin Ye,Kuan Yang,Yuesheng Zuo,Shuai Ma,Yun-Gui Yang,Jing Qu,Feng Zhang,Peilin Jia,Guang-Hui Liu,Weiqi Zhang
Epigenetic clocks are accurate predictors of human chronological age based on the analysis of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison between DNA methylation data and other omics datasets has not yet been performed. Moreover, available DNAm age predictors are based on datasets with limited ethnic representation. To address these knowledge gaps, we generated and
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Skeletal stem cells in bone development, homeostasis, and disease. Protein Cell (IF 13.6) Pub Date : 2024-07-20 Guixin Yuan,Xixi Lin,Ying Liu,Matthew B Greenblatt,Ren Xu
Tissue-resident stem cells are essential for development and repair, and in the skeleton, this function is fulfilled by recently identified skeletal stem cells (SSCs). However, recent work has identified that SSCs are not monolithic, with long bones, craniofacial sites, and the spine being formed by distinct stem cells. Recent studies have utilized techniques such as fluorescence-activated cell sorting
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Single-cell transcriptomic Atlas of aging macaque ocular outflow tissues. Protein Cell (IF 13.6) Pub Date : 2024-07-20 Jian Wu,Chaoye Wang,Shuhui Sun,Tianmin Ren,Lijie Pan,Hongyi Liu,Simeng Hou,Shen Wu,Xuejing Yan,Jingxue Zhang,Xiaofang Zhao,Weihai Liu,Sirui Zhu,Shuwen Wei,Chi Zhang,Xu Jia,Qi Zhang,Ziyu Yu,Yehong Zhuo,Qi Zhao,Chenlong Yang,Ningli Wang
The progressive degradation in the trabecular meshwork (TM) is related to age-related ocular diseases like primary open-angle glaucoma. However, the molecular basis and biological significance of the aging process in TM have not been fully elucidated. Here, we established a dynamic single-cell transcriptomic landscape of aged macaque TM, wherein we classified the outflow tissue into 12 cell subtypes
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Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics. Protein Cell (IF 13.6) Pub Date : 2024-07-01 Tao Chen,Yiliang Xu,Xiaocui Xu,Jianzhang Wang,Zhiruo Qiu,Yayuan Yu,Xiaohong Jiang,Wanqi Shao,Dandan Bai,Mingzhu Wang,Shuyan Mei,Tao Cheng,Li Wu,Shaorong Gao,Xuan Che
Adenomyosis is a poorly understood gynecological disorder lacking effective treatments. Controversy persists regarding "invagination" and "metaplasia" theories. The endometrial-myometrial junction (EMJ) connects the endometrium and myometrium and is important for diagnosing and classifying adenomyosis, but its in-depth study is just beginning. Using single-cell RNA sequencing and spatial profiling
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Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation. Protein Cell (IF 13.6) Pub Date : 2024-07-01 Kai-Hui Zhang,Fei-Fei Zhang,Zhi-Ling Zhang,Ke-Fei Fang,Wen-Xing Sun,Na Kong,Min Wu,Hai-Ou Liu,Yan Liu,Zhi Li,Qing-Qing Cai,Yang Wang,Quan-Wei Wei,Peng-Cheng Lin,Yan Lin,Wei Xu,Cong-Jian Xu,Yi-Yuan Yuan,Shi-Min Zhao
Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility. Inadequate understanding of the ovulation drivers hinders PCOS intervention. Herein, we report that follicle stimulating hormone (FSH) controls follicular fluid (FF) glutamine levels to determine ovulation. Murine ovulation starts from FF-exposing granulosa cell (GC) apoptosis. FF glutamine, which decreases in pre-ovulation
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Long way up: rethink diseases in light of phase separation and phase transition. Protein Cell (IF 13.6) Pub Date : 2024-07-01 Mingrui Ding,Weifan Xu,Gaofeng Pei,Pilong Li
Biomolecular condensation, driven by multivalency, serves as a fundamental mechanism within cells, facilitating the formation of distinct compartments, including membraneless organelles that play essential roles in various cellular processes. Perturbations in the delicate equilibrium of condensation, whether resulting in gain or loss of phase separation, have robustly been associated with cellular
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PKM2, the "K+ sink" in the tumor interstitial fluid. Protein Cell (IF 13.6) Pub Date : 2024-06-24 Wenjing Na,Wenfeng Zeng,Kai Song,Youwang Wang,Luoyang Wang,Ziran Zhao,Lingtao Jin,Ping Zhu,Wei Liang
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CRISPR-based screening pinpoints H2AZ1 as a driver of senescence in human mesenchymal stem cells. Protein Cell (IF 13.6) Pub Date : 2024-06-19 Ming-Heng Li,Xiaoyu Jiang,Yaobin Jing,Kaowen Yan,Shi-Jia Bi,Si Wang,Shuai Ma,Guang-Hui Liu,Weiqi Zhang,Shuhui Sun,Jing Qu
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A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignances. Protein Cell (IF 13.6) Pub Date : 2024-06-01 Lijun Zhao,Shuhong Li,Xiaoyi Wei,Xuexiu Qi,Qiaoru Guo,Licai Shi,Ji-Shuai Zhang,Jun Li,Ze-Lin Liu,Zhi Guo,Hongyu Zhang,Jia Feng,Yuanyuan Shi,Suping Zhang,Yu J Cao
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Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion. Protein Cell (IF 13.6) Pub Date : 2024-05-28 Song Xue,Yuru Han,Fan Wu,Qiao Wang
Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes and results in various novel variants with distinct mutation profiles. Point mutations, particularly those within the receptor binding domain (RBD) of SARS-CoV-2 spike (S) protein, lead to the functional alteration in both receptor engagement and monoclonal antibody (mAb) recognition. Here, we review the data
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Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy. Protein Cell (IF 13.6) Pub Date : 2024-05-28 Chenxiang Xi,Zihui Yan,Dandan Bai,Yalin Zhang,Beiying Wang,Xiaoxiao Han,Li Wu,Xiaohui Shi,Zhiyi Hu,Ming Tang,Zhongqu Su,Yingdong Liu,Binya Liu,Jiqing Yin,Hong Wang,Xiaocui Li,Yanping Zhang,Shaorong Gao,Wenqiang Liu
The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) remains a threat to pregnant women. However, the impact of early pregnancy SARS-CoV-2 infection on the maternal-fetal interface remains poorly understood. Here, we present a comprehensive analysis of single-cell transcriptomics and metabolomics in placental samples infected
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Microbiota enterotoxigenic Bacteroides fragilis-secreted BFT-1 promotes breast cancer cell stemness and chemoresistance through its functional receptor NOD1. Protein Cell (IF 13.6) Pub Date : 2024-05-28 Wei Ma,Lu Zhang,Weilong Chen,Zhaoxia Chang,Juchuanli Tu,Yuanyuan Qin,Yuwen Yao,Mengxue Dong,Jiajun Ding,Siqin Li,Fengkai Li,Qiaodan Deng,Yifei Yang,Tingting Feng,Fanrong Zhang,Xiying Shao,Xueyan He,Lixing Zhang,Guohong Hu,Quentin Liu,Yi-Zhou Jiang,Shu Zhu,Zhi Xiao,Dan Su,Tong Liu,Suling Liu
Tumor-resident microbiota in breast cancer promotes cancer initiation and malignant progression. However, targeting microbiota to improve the effects of breast cancer therapy has not been investigated in detail. Here, we evaluated the microbiota composition of breast tumors and found that enterotoxigenic Bacteroides fragilis (ETBF) was highly enriched in the tumors of patients who did not respond to
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Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling. Protein Cell (IF 13.6) Pub Date : 2024-05-28 Feifei Liu,Yi Lu,Xuebao Wang,Shuhui Sun,Huize Pan,Min Wang,Zehua Wang,Weiqi Zhang,Shuai Ma,Guoqiang Sun,Qun Chu,Si Wang,Jing Qu,Guang-Hui Liu
The synovium, a thin layer of tissue that is adjacent to the joints and secretes synovial fluid, undergoes changes in aging that contribute to intense shoulder pain and other joint diseases. However, the mechanism underlying human synovial aging remains poorly characterized. Here, we generated a comprehensive transcriptomic profile of synovial cells present in the subacromial synovium from young and
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NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody. Protein Cell (IF 13.6) Pub Date : 2024-10-01 Xiaoyang Xu,Yuliang Huang,Feng Yang,Xiaoxia Sun,Rijin Lin,Jiaxing Feng,Mingyang Yang,Jiaqi Shao,Xiaoqi Liu,Tianhua Zhou,Shanshan Xie,Yuehong Yang
Cytokinesis is required for faithful division of cytoplasmic components and duplicated nuclei into two daughter cells. Midbody, a protein-dense organelle that forms at the intercellular bridge, is indispensable for successful cytokinesis. However, the regulatory mechanism of cytokinesis at the midbody still remains elusive. Here, we unveil a critical role for NudC-like protein 2 (NudCL2), a co-chaperone
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Integrative analysis of transcriptome, DNA methylome and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathy. Protein Cell (IF 13.6) Pub Date : 2024-05-23 Junpeng Gao,Mengya Liu,Minjie Lu,Yuxuan Zheng,Yan Wang,Jingwei Yang,Xiaohui Xue,Yun Liu,Fuchou Tang,Shuiyun Wang,Lei Song,Lu Wen,Jizheng Wang
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and is characterized by primary left ventricular hypertrophy usually caused by mutations in sarcomere genes. The mechanism underlying cardiac remodeling in HCM remains incompletely understood. An investigation of HCM through integrative analysis at multi-omics levels will be helpful for treating HCM. DNA methylation and chromatin
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High-throughput single-microbe RNA sequencing reveals adaptive state heterogeneity and host-phage activity associations in human gut microbiome. Protein Cell (IF 13.6) Pub Date : 2024-05-23 Yifei Shen,Qinghong Qian,Liguo Ding,Wenxin Qu,Tianyu Zhang,Mengdi Song,Yingjuan Huang,Mengting Wang,Ziye Xu,Jiaye Chen,Ling Dong,Hongyu Chen,Enhui Shen,Shufa Zheng,Yu Chen,Jiong Liu,Longjiang Fan,Yongcheng Wang
Microbial communities such as those residing in the human gut are highly diverse and complex, and many with important implications in health and diseases. The effects and functions of these microbial communities are determined not only by their species compositions and diversities but also by the dynamic intra- and inter-cellular states at the transcriptional level. Powerful and scalable technologies
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ARID1A IDR Targets EWS-FLI1 Condensates and Finetunes Chromatin Remodeling. Protein Cell (IF 13.6) Pub Date : 2024-05-18 Jingdong Xue,Siang Lv,Ming Yu,Yixuan Pan,Ningzhe Li,Xiang Xu,Qi Zhang,Mengyuan Peng,Fang Liu,Xuxu Sun,Yimin Lao,Yanhua Yao,Juan Song,Jun Wu,Bing Li
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SMAD2/3-SMYD2 and developmental transcription factors cooperate with cell cycle inhibitors to guide tissue formation. Protein Cell (IF 13.6) Pub Date : 2024-05-17 Stefania Militi,Reshma Nibhani,Martin Pook,Siim Pauklin
Tissue formation and organ homeostasis is achieved by precise coordination of proliferation and differentiation of stem cells and progenitors. While deregulation of these processes can result in degenerative disease or cancer, their molecular interplays remain unclear. Here we show that the switch of human pluripotent stem cell (hPSC) self-renewal to differentiation is associated with the induction
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IL-24 promotes atopic dermatitis-like inflammation through driving MRSA-induced allergic responses. Protein Cell (IF 13.6) Pub Date : 2024-05-16 Xinmin Qian,Meiyi Tong,Tianqing Zhang,Qingqing Li,Meng Hua,Nan Zhou,Wenwen Zeng
Atopic dermatitis (AD) is a prevalent inflammatory skin disorder in which patients experience recurrent eczematous lesions and intense itching. The colonization of Staphylococcus aureus (S. aureus) is correlated with the severity of the disease, but its role in AD development remains elusive. Using single-cell RNA sequencing, we uncovered that keratinocytes activate a distinct immune response characterized
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Syn3, a newly developed cyclic peptide and BDNF signaling enhancer, ameliorates retinal ganglion cell degeneration in diabetic retinopathy. Protein Cell (IF 13.6) Pub Date : 2024-05-14 Ke-Ran Li,Meng-Jia Huan,Jin Yao,Jia-Jun Li,Yuan Cao,Suyu Wang,Mandar T Naik,Yuan Fang,John Marshall,Chang-Gong Lan,Cong Cao
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Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy. Protein Cell (IF 13.6) Pub Date : 2024-05-11 Qiuyang Zheng,Xin Wang
Alzheimer's disease (AD), the leading cause of dementia, is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the brain. This condition casts a significant shadow on global health due to its complex and multifactorial nature. In addition to genetic predispositions, the development of AD is influenced by a myriad of risk factors, including aging, systemic inflammation
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p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells. Protein Cell (IF 13.6) Pub Date : 2024-05-09 Nini Wang,Shangda Yang,Yu Li,Fanglin Gou,Yanling Lv,Xiangnan Zhao,Yifei Wang,Chang Xu,Bin Zhou,Fang Dong,Zhenyu Ju,Tao Cheng,Hui Cheng
The maintenance of hematopoietic stem cells (HSCs) is a complex process involving numerous cell-extrinsic and -intrinsic regulators. The first member of the cyclin-dependent kinase family of inhibitors to be identified, p21, has been reported to perform a wide range of critical biological functions, including cell cycle regulation, transcription, differentiation, and so on. Given the previous inconsistent
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Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate ageing in mice. Protein Cell (IF 13.6) Pub Date : 2024-05-09 Sipeng Wu,Yiqi Cai,Lixiao Zhang,Xiang Li,Xu Liu,Guangkeng Zhou,Hongdi Luo,Renjian Li,Yujia Huo,Zhirong Zhang,Siyi Chen,Jinliang Huang,Jiahao Shi,Shanwei Ding,Zhe Sun,Zizhuo Zhou,Pengcheng Wang,Geng Wang
One of the basic questions in the ageing field is whether there is fundamental difference between the ageing of lower invertebrates and mammals. A major difference between the lower invertebrates and mammals is the abundancy of noncoding RNAs, most of which are not conserved. We have previously identified a noncoding RNA Terc-53 that is derived from the RNA component of telomerase Terc. To study its
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Exploring unconventional attributes of red blood cells and their potential applications in biomedicine. Protein Cell (IF 13.6) Pub Date : 2024-05-07 Alkmini T Anastasiadi,Vasiliki-Zoi Arvaniti,Krystalyn E Hudson,Anastasios G Kriebardis,Constantinos Stathopoulos,Angelo D'Alessandro,Steven L Spitalnik,Vassilis L Tzounakas
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Degeneration Directory: a multi-omics web resource for degenerative diseases. Protein Cell (IF 13.6) Pub Date : 2024-05-07 Haoteng Yan,Changfa Lu,Chenyang Lan,Si Wang,Weiqi Zhang,Zan He,Jinghao Hu,Jiaqi Ai,Guang-Hui Liu,Shuai Ma,Yuanchun Zhou,Jing Qu
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Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics. Protein Cell (IF 13.6) Pub Date : 2024-05-07 Huifen Lu,Ying Jing,Chen Zhang,Shuai Ma,Weiqi Zhang,Daoyuan Huang,Bin Zhang,Yuesheng Zuo,Yingying Qin,Guang-Hui Liu,Yang Yu,Jing Qu,Si Wang
The ovary is indispensable for female reproduction, and its age-dependent functional decline is the primary cause of infertility. However, the molecular basis of ovarian aging in higher vertebrates remains poorly understood. Herein, we apply spatiotemporal transcriptomics to benchmark architecture organization as well as cellular and molecular determinants in young primate ovaries and compare these
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Correction to: Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells. Protein Cell (IF 13.6) Pub Date : 2024-05-07
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Whole-exome sequencing identifies ECPAS as a novel potentially pathogenic gene in multiple hereditary families with nonsyndromic orofacial cleft. Protein Cell (IF 13.6) Pub Date : 2024-10-01 Huaxiang Zhao,Wenjie Zhong,Wenbin Huang,Guozhu Ning,Jieni Zhang,Mengqi Zhang,Peiqi Meng,Yunfan Zhang,Qian Zhang,Hongping Zhu,Gulibaha Maimaitili,Yi Ding,Weiran Li,Wei Liang,Zhibo Zhou,Qiang Wang,Feng Chen,Jiuxiang Lin
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Dissecting caspase-2-mediated cell death: from intrinsic PIDDosome activation to chemical modulation. Protein Cell (IF 13.6) Pub Date : 2024-04-27 Mengxue Zeng,Kun Wang,Qingcui Wu,Jingjin Ding,Dan Xie,Xiangbing Qi,Feng Shao
Caspase-2, a highly conserved member of the caspase family, is considered an initiator caspase that triggers apoptosis in response to some cellular stresses. Previous studies suggest that an intracellular multi-protein complex PIDDosome, induced by genotoxic stress, serves as a platform for caspase-2 activation. However, due to caspase-2's inability to process effector caspases, the mechanism underlying
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Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration. Protein Cell (IF 13.6) Pub Date : 2024-04-18 Yinghui Li,Xingchen Liu,Xue Sun,Hui Li,Shige Wang,Wotu Tian,Chen Xiang,Xuyuan Zhang,Jiajia Zheng,Haifang Wang,Liguo Zhang,Li Cao,Catherine C L Wong,Zhihua Liu
Scavenger receptor class B, member 2 (SCARB2) is linked to Gaucher disease (GD) and Parkinson's disease (PD). Deficiency in the SCARB2 gene causes progressive myoclonus epilepsy (PME), a rare group of inherited neurodegenerative diseases characterized by myoclonus. We found that Scarb2 deficiency in mice leads to age-dependent dietary lipid malabsorption, accompanied with vitamin E deficiency. Our
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Discovery of CCDC188 gene as a novel genetic target for human acephalic spermatozoa syndrome. Protein Cell (IF 13.6) Pub Date : 2024-09-01 Jing Wang,Hui-Juan Jin,Yi Lu,Zi-Han Wang,Teng-Yan Li,Lan Xia,Hong-Jun Li,Bin-Bin Wang,Su-Ren Chen
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Ca2+ binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing. Protein Cell (IF 13.6) Pub Date : 2024-04-01 Han Chen,Mehar Monga,Qinghua Fang,Loujin Slitin,Jakob Neef,Shashank S Chepurwar,Regina Célia Mingroni Netto,Karina Lezirovitz,Alfredo Tabith,Fritz Benseler,Nils Brose,Kathrin Kusch,Carolin Wichmann,Nicola Strenzke,Barbara Vona,Julia Preobraschenski,Tobias Moser
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Correction to: Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell (IF 13.6) Pub Date : 2024-04-01
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Macrophages suppress cardiac reprogramming of fibroblasts in vivo via IFN-mediated intercellular self-stimulating circuit. Protein Cell (IF 13.6) Pub Date : 2024-03-26 Hao Wang,Junbo Yang,Yihong Cai,Yang Zhao
Direct conversion of cardiac fibroblasts (CFs) to cardiomyocytes (CMs) in vivo to regenerate heart tissue is an attractive approach. After myocardial infarction (MI), heart repair proceeds with an inflammation stage initiated by monocytes infiltration of the infarct zone establishing an immune microenvironment. However, whether and how the MI microenvironment influences the reprogramming of CFs remains
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Engineered extracellular vesicles enable high-efficient delivery of intracellular therapeutic proteins. Protein Cell (IF 13.6) Pub Date : 2024-10-01 Ding Ma,An Xie,Jiahui Lv,Xiaolin Min,Xinye Zhang,Qian Zhou,Daxing Gao,Enyu Wang,Lei Gao,Linzhao Cheng,Senquan Liu
Developing an intracellular delivery system is of key importance in the expansion of protein-based therapeutics acting on cytosolic or nuclear targets. Recently, extracellular vesicles (EVs) have been exploited as next-generation delivery modalities due to their natural role in intercellular communication and biocompatibility. However, fusion of protein of interest to a scaffold represents a widely
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CARM1 drives triple-negative breast cancer progression by coordinating with HIF1A. Protein Cell (IF 13.6) Pub Date : 2024-10-01 Dandan Feng,Jie Gao,Ruiqiong Liu,Wei Liu,Tianyang Gao,Yunkai Yang,Die Zhang,Tianshu Yang,Xin Yin,Hefen Yu,Wei Huang,Yan Wang
Coactivator-associated arginine methyltransferase 1 (CARM1) promotes the development and metastasis of estrogen receptor alpha (ERα)-positive breast cancer. The function of CARM1 in triple-negative breast cancer (TNBC) is still unclear and requires further exploration. Here, we report that CARM1 promotes proliferation, epithelial-mesenchymal transition, and stemness in TNBC. CARM1 is upregulated in
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Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis. Protein Cell (IF 13.6) Pub Date : 2024-09-01 Xiaoguang Liu,Zhen Chen,Yuelong Yan,Fereshteh Zandkarimi,Litong Nie,Qidong Li,Amber Horbath,Kellen Olszewski,Lavanya Kondiparthi,Chao Mao,Hyemin Lee,Li Zhuang,Masha Poyurovsky,Brent R Stockwell,Junjie Chen,Boyi Gan
Ferroptosis has been recognized as a unique cell death modality driven by excessive lipid peroxidation and unbalanced cellular metabolism. In this study, we established a protein interaction landscape for ferroptosis pathways through proteomic analyses, and identified choline/ethanolamine phosphotransferase 1 (CEPT1) as a lysophosphatidylcholine acyltransferase 3 (LPCAT3)-interacting protein that regulates
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Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond. Protein Cell (IF 13.6) Pub Date : 2024-09-01 Chao Mao,Min Wang,Li Zhuang,Boyi Gan
Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism. This review discusses the mechanisms of metabolic cell death-ferroptosis, cuproptosis, disulfidptosis, lysozincrosis, and alkaliptosis-and explores their potential in cancer therapy. Our review underscores
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Cryo-EM structure of cannabinoid receptor CB1-β-arrestin complex. Protein Cell (IF 13.6) Pub Date : 2024-02-29 Yuxia Wang,Lijie Wu,Tian Wang,Junlin Liu,Fei Li,Longquan Jiang,Zhongbo Fan,Yanan Yu,Na Chen,Qianqian Sun,Qiwen Tan,Tian Hua,Zhi-Jie Liu
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The expanded application of CAR-T cell therapy for the treatment of multiple non-tumoral diseases. Protein Cell (IF 13.6) Pub Date : 2024-09-01 Zhuoqun Liu,Yuchen Xiao,Jianjun Lyu,Duohui Jing,Liu Liu,Yanbin Fu,Wenxin Niu,Lingjing Jin,Chao Zhang
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Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice. Protein Cell (IF 13.6) Pub Date : 2024-04-01 He-Zhou Huang,Wen-Qing Ai,Na Wei,Ling-Shuang Zhu,Zhi-Qiang Liu,Chao-Wen Zhou,Man-Fei Deng,Wen-Tao Zhang,Jia-Chen Zhang,Chun-Qing Yang,Ya-Zhuo Hu,Zhi-Tao Han,Hong-Hong Zhang,Jian-Jun Jia,Jing Wang,Fang-Fang Liu,Ke Li,Qi Xu,Mei Yuan,Hengye Man,Ziyuan Guo,Youming Lu,Kai Shu,Ling-Qiang Zhu,Dan Liu
Sporadic or late-onset Alzheimer's disease (LOAD) accounts for more than 95% of Alzheimer's disease (AD) cases without any family history. Although genome-wide association studies have identified associated risk genes and loci for LOAD, numerous studies suggest that many adverse environmental factors, such as social isolation, are associated with an increased risk of dementia. However, the underlying
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ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader. Protein Cell (IF 13.6) Pub Date : 2024-07-01 Chuanle Wang,Yan Huang,Yue Yang,Ruofei Li,Yingying Li,Hongxin Qiu,Jiali Wu,Guang Shi,Wenbin Ma,Zhou Songyang
Telomeres are specialized structures at the ends of linear chromosomes that protect genome stability. The telomeric repeat-containing RNA (TERRA) that is transcribed from subtelomeric regions can invade into double-stranded DNA regions and form RNA:DNA hybrid-containing structure called R-loop. In tumor cells, R-loop formation is closely linked to gene expression and the alternative lengthening of
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Emerging clinical relevance of microbiome in cancer: promising biomarkers and therapeutic targets. Protein Cell (IF 13.6) Pub Date : 2024-04-01 Jia-Hao Dai,Xi-Rong Tan,Han Qiao,Na Liu
The profound influence of microbiota in cancer initiation and progression has been under the spotlight for years, leading to numerous researches on cancer microbiome entering clinical evaluation. As promising biomarkers and therapeutic targets, the critical involvement of microbiota in cancer clinical practice has been increasingly appreciated. Here, recent progress in this field is reviewed. We describe
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The microbiota-gut-brain axis and neurodevelopmental disorders. Protein Cell (IF 13.6) Pub Date : 2023-10-25 Qinwen Wang,Qianyue Yang,Xingyin Liu
The gut microbiota has been found to interact with the brain through the microbiota-gut-brain axis, regulating various physiological processes. In recent years, the impacts of the gut microbiota on neurodevelopment through this axis have been increasingly appreciated. The gut microbiota is commonly considered to regulate neurodevelopment through three pathways, the immune pathway, the neuronal pathway
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Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death. Protein Cell (IF 13.6) Pub Date : 2024-02-01 Xinhe Gao,Teng Teng,Yifei Liu,Tingting Ai,Rui Zhao,Yilong Fu,Peipei Zhang,Jiahuai Han,Yingying Zhang
Bacillus anthracis lethal toxin (LT) is a determinant of lethal anthrax. Its function in myeloid cells is required for bacterial dissemination, and LT itself can directly trigger dysfunction of the cardiovascular system. The interplay between LT and the host responses is important in the pathogenesis, but our knowledge on this interplay remains limited. Tumor necrosis factor-α (TNF-α) is a pleiotropic
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Applications of genetic code expansion technology in eukaryotes. Protein Cell (IF 13.6) Pub Date : 2024-05-07 Qiao-Ru Guo,Yu J Cao
Unnatural amino acids (UAAs) have gained significant attention in protein engineering and drug development owing to their ability to introduce new chemical functionalities to proteins. In eukaryotes, genetic code expansion (GCE) enables the incorporation of UAAs and facilitates posttranscriptional modification (PTM), which is not feasible in prokaryotic systems. GCE is also a powerful tool for cell
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Long-term in vivo chimeric cells tracking in non-human primate. Protein Cell (IF 13.6) Pub Date : 2024-02-29 Junmo Wu,Yu Kang,Xiang Luo,Shaoxing Dai,Yuxi Shi,Zhuoyao Li,Zengli Tang,Zhenzhen Chen,Ran Zhu,Pengpeng Yang,Zifan Li,Hong Wang,Xinglong Chen,Ziyi Zhao,Weizhi Ji,Yuyu Niu
Non-human primates (NHPs) are increasingly used in preclinical trials to test the safety and efficacy of biotechnology therapies. Nonetheless, given the ethical issues and costs associated with this model, it would be highly advantageous to use NHP cellular models in clinical studies. However, developing and maintaining the naïve state of primate pluripotent stem cells (PSCs) remains difficult as does