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The early days of structural biology at the Beijing Institute of Biophysics: In memory of Professor Zhengjiong Lin (1935–2022) Protein Cell (IF 14.87) Pub Date : 2022-04-24 Jia-huai Wang
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Connecting past and present: single-cell lineage tracing Protein Cell (IF 14.87) Pub Date : 2022-04-19 Cheng Chen, Yuanxin Liao, Guangdun Peng
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Postnatal state transition of cardiomyocyte as a primary step in heart maturation Protein Cell (IF 14.87) Pub Date : 2022-04-08 Zheng Li, Fang Yao, Peng Yu, Dandan Li, Mingzhi Zhang, Lin Mao, Xiaomeng Shen, Zongna Ren, Li Wang, Bingying Zhou
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Targeting papain-like protease for broad-spectrum coronavirus inhibition Protein Cell (IF 14.87) Pub Date : 2022-04-06 Shuofeng Yuan, Xiaopan Gao, Kaiming Tang, Jian-Piao Cai, Menglong Hu, Peng Luo, Lei Wen, Zi-Wei Ye, Cuiting Luo, Jessica Oi-Ling Tsang, Chris Chun-Yiu Chan, Yaoqiang Huang, Jianli Cao, Ronghui Liang, Zhenzhi Qin, Bo Qin, Feifei Yin, Hin Chu, Dong-Yan Jin, Ren Sun, Jasper Fuk-Woo Chan, Sheng Cui, Kwok-Yung Yuen
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SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation Protein Cell (IF 14.87) Pub Date : 2022-04-06 Yichen Li, Shuaiyao Lu, Jinge Gu, Wencheng Xia, Shengnan Zhang, Shenqing Zhang, Yan Wang, Chong Zhang, Yunpeng Sun, Jian Lei, Cong Liu, Zhaoming Su, Juntao Yang, Xiaozhong Peng, Dan Li
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FTO stabilizes MIS12 and counteracts senescence Protein Cell (IF 14.87) Pub Date : 2022-04-06 Sheng Zhang, Zeming Wu, Yue Shi, Si Wang, Jie Ren, Zihui Yu, Daoyuan Huang, Kaowen Yan, Yifang He, Xiaoqian Liu, Qianzhao Ji, Beibei Liu, Zunpeng Liu, Jing Qu, Guang-Hui Liu, Weimin Ci, Xiaoqun Wang, Weiqi Zhang
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Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques Protein Cell (IF 14.87) Pub Date : 2022-04-04 Chun-Chun Gao, Man Li, Wei Deng, Chun-Hui Ma, Yu-Sheng Chen, Yong-Qiao Sun, Tingfu Du, Qian-Lan Liu, Wen-Jie Li, Bing Zhang, Lihong Sun, Si-Meng Liu, Fengli Li, Feifei Qi, Yajin Qu, Xinyang Ge, Jiangning Liu, Peng Wang, Yamei Niu, Zhiyong Liang, Yong-Liang Zhao, Bo Huang, Xiao-Zhong Peng, Ying Yang, Chuan Qin, Wei-Min Tong, Yun-Gui Yang
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Gonadal mosaicism mediated female-biased gender control in mice. Protein Cell (IF 14.87) Pub Date : 2022-03-25 Meizhu Bai,Dan Liang,Yan Cheng,Guolong Liu,Qiudao Wang,Jinsong Li,Yuxuan Wu
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New pathogenic insights from large animal models of neurodegenerative diseases Protein Cell (IF 14.87) Pub Date : 2022-03-25 Peng Yin, Shihua Li, Xiao-Jiang Li, Weili Yang
Animal models are essential for investigating the pathogenesis and developing the treatment of human diseases. Identification of genetic mutations responsible for neurodegenerative diseases has enabled the creation of a large number of small animal models that mimic genetic defects found in the affected individuals. Of the current animal models, rodents with genetic modifications are the most commonly
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Efficient expansion of rare human circulating hematopoietic stem/progenitor cells in steady-state blood using a polypeptide-forming 3D culture Protein Cell (IF 14.87) Pub Date : 2022-03-01 Yulin Xu, Xiangjun Zeng, Mingming Zhang, Binsheng Wang, Xin Guo, Wei Shan, Shuyang Cai, Qian Luo, Honghu Li, Xia Li, Xue Li, Hao Zhang, Limengmeng Wang, Yu Lin, Lizhen Liu, Yanwei Li, Meng Zhang, Xiaohong Yu, Pengxu Qian, He Huang
Although widely applied in treating hematopoietic malignancies, transplantation of hematopoietic stem/progenitor cells (HSPCs) is impeded by HSPC shortage. Whether circulating HSPCs (cHSPCs) in steady-state blood could be used as an alternative source remains largely elusive. Here we develop a three-dimensional culture system (3DCS) including arginine, glycine, aspartate, and a series of factors. Fourteen-day
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Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer Protein Cell (IF 14.87) Pub Date : 2022-02-26 Junru Feng, Hui Lu, Wenhao Ma, Wenjing Tian, Zhuan Lu, Hongying Yang, Yongping Cai, Pengfei Cai, Yuchen Sun, Zilong Zhou, Jiaqian Feng, Jiazhong Deng, Ying Shu, Kun Qu, Weidong Jia, Ping Gao, Huafeng Zhang
Metformin is currently a strong candidate anti-tumor agent in multiple cancers. However, its anti-tumor effectiveness varies among different cancers or subpopulations, potentially due to tumor heterogeneity. It thus remains unclear which hepatocellular carcinoma (HCC) patient subpopulation(s) can benefit from metformin treatment. Here, through a genome-wide CRISPR-Cas9-based knockout screen, we find
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Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis. Protein Cell (IF 14.87) Pub Date : 2022-02-17 Xiaolong Ma,Jiacheng Deng,Lulu Han,Yuwei Song,Yutong Miao,Xing Du,Guohui Dang,Dongmin Yang,Bitao Zhong,Changtao Jiang,Wei Kong,Qingbo Xu,Juan Feng,Xian Wang
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A framework for the responsible reform of the 14-day rule in human embryo research. Protein Cell (IF 14.87) Pub Date : 2022-02-15 Yaojin Peng,Jianwei Lv,Zhenyu Xiao,Lulu Ding,Qi Zhou
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BMP4 preserves the developmental potential of mESCs through Ube2s- and Chmp4b-mediated chromosomal stability safeguarding Protein Cell (IF 14.87) Pub Date : 2022-02-11 Mingzhu Wang, Kun Zhao, Meng Liu, Mengting Wang, Zhibin Qiao, Shanru Yi, Yonghua Jiang, Xiaochen Kou, Yanhong Zhao, Jiqing Yin, Tianming Li, Hong Wang, Cizhong Jiang, Shaorong Gao, Jiayu Chen
Chemically defined medium is widely used for culturing mouse embryonic stem cells (mESCs), in which N2B27 works as a substitution for serum, and GSK3β and MEK inhibitors (2i) help to promote ground-state pluripotency. However, recent studies suggested that MEKi might cause irreversible defects that compromise the developmental potential of mESCs. Here, we demonstrated the deficient bone morphogenetic
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mTORC2/RICTOR exerts differential levels of metabolic control in human embryonic, mesenchymal and neural stem cells. Protein Cell (IF 14.87) Pub Date : 2022-01-17 Qun Chu,Feifei Liu,Yifang He,Xiaoyu Jiang,Yusheng Cai,Zeming Wu,Kaowen Yan,Lingling Geng,Yichen Zhang,Huyi Feng,Kaixin Zhou,Si Wang,Weiqi Zhang,Guang-Hui Liu,Shuai Ma,Jing Qu,Moshi Song
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Correction to: Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction Protein Cell (IF 14.87) Pub Date : 2022-01-15 Si Wang,Zheying Min,Qianzhao Ji,Lingling Geng,Yao Su,Zunpeng Liu,Huifang Hu,Lixia Wang,Weiqi Zhang,Keiichiro Suzuiki,Yu Huang,Puyao Zhang,Tie-Shan Tang,Jing Qu,Yang Yu,Guang-Hui Liu,Jie Qiao
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Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis Protein Cell (IF 14.87) Pub Date : 2022-01-12 Wang, Yuting, Liu, Liping, Song, Yifan, Yu, Xiaojie, Deng, Hongkui
Senescence, a stable state of growth arrest, affects many physiological and pathophysiological processes, especially aging. Previous work has indicated that transcription factors (TFs) play a role in regulating senescence. However, a systematic study of regulatory TFs during replicative senescence (RS) using multi-omics analysis is still lacking. Here, we generated time-resolved RNA-seq, reduced representation
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8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI Protein Cell (IF 14.87) Pub Date : 2022-01-11 Tai, Linhua, Zhu, Yun, Ren, He, Huang, Xiaojun, Zhang, Chuanmao, Sun, Fei
The nuclear pore complex (NPC), one of the largest protein complexes in eukaryotes, serves as a physical gate to regulate nucleocytoplasmic transport. Here, we determined the 8 Å resolution cryo-electron microscopic (cryo-EM) structure of the outer rings containing nuclear ring (NR) and cytoplasmic ring (CR) from the Xenopus laevis NPC, with local resolutions reaching 4.9 Å. With the aid of AlphaFold2
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Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell (IF 14.87) Pub Date : 2022-06-01 Wei Li,Zhiran Zou,Yusheng Cai,Kuan Yang,Si Wang,Zunpeng Liu,Lingling Geng,Qun Chu,Zhejun Ji,Piu Chan,Guang-Hui Liu,Moshi Song,Jing Qu,Weiqi Zhang
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Identification of a novel cDC2-committed progenitor within mouse common dendritic cell progenitor population. Protein Cell (IF 14.87) Pub Date : 2022-04-01 Yujie Tian,Xueheng Guo,Tao Wu,Kuangyu Fei,Li Wu
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Correction to: PINK1 mediates neuronal survival in monkey. Protein Cell (IF 14.87) Pub Date : 2022-04-01 Ziyu Sun,Jianyu Ye,Junying Yuan
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Governing glutaminolysis by regulation of glutaminase succinylation. Protein Cell (IF 14.87) Pub Date : 2021-12-16 Qingxia Ma,Hongfei Jiang,Leina Ma,Ying Meng,Dong Guo,Yingying Tong,Zhimin Lu
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Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis. Protein Cell (IF 14.87) Pub Date : 2021-12-10 Li Yang,Jin Chen,Jianqing Liang,Yufeng Zhang,Qingzhe Wang,Xiaojun Ren,Jinsong Wei,Qianchun Gong,Jiting Zhang,Ning Jiang,Xinhua Lin,Jin Li,Bing Zhao
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Epigenetic integrity of paternal imprints enhances the developmental potential of androgenetic haploid embryonic stem cells Protein Cell (IF 14.87) Pub Date : 2021-12-05 Zhang, Hongling, Li, Yuanyuan, Ma, Yongjian, Lai, Chongping, Yu, Qian, Shi, Guangyong, Li, Jinsong
The use of two inhibitors of Mek1/2 and Gsk3β (2i) promotes the generation of mouse diploid and haploid embryonic stem cells (ESCs) from the inner cell mass of biparental and uniparental blastocysts, respectively. However, a system enabling long-term maintenance of imprints in ESCs has proven challenging. Here, we report that the use of a two-step a2i (alternative two inhibitors of Src and Gsk3β, TSa2i)
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Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells Protein Cell (IF 14.87) Pub Date : 2021-11-30 Tian, Chenglei, Liu, Linlin, Zeng, Ming, Sheng, Xiaoyan, Heng, Dai, Wang, Lingling, Ye, Xiaoying, Keefe, David L., Liu, Lin
Parthenogenetic embryos, created by activation and diploidization of oocytes, arrest at mid-gestation for defective paternal imprints, which impair placental development. Also, viable offspring has not been obtained without genetic manipulation from parthenogenetic embryonic stem cells (pESCs) derived from parthenogenetic embryos, presumably attributable to their aberrant imprinting. We show that an
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Ferroptosis as an important driver of lupus. Protein Cell (IF 14.87) Pub Date : 2021-11-26 Chao Mao,Guang Lei,Li Zhuang,Boyi Gan
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Academician Qi-Yi Xing (Chi-Yi Hsing): pioneer organic chemist of synthetic insulin. Protein Cell (IF 14.87) Pub Date : 2021-11-26 Ming-Hua Qiu
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PINK1 mediates neuronal survival in monkey. Protein Cell (IF 14.87) Pub Date : 2021-11-23 Zhiyu Sun,Jiangyu Ye,Junying Yuan
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PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis Protein Cell (IF 14.87) Pub Date : 2021-11-20 Yang, Weili, Guo, Xiangyu, Tu, Zhuchi, Chen, Xiusheng, Han, Rui, Liu, Yanting, Yan, Sen, Wang, Qi, Wang, Zhifu, Zhao, Xianxian, Zhang, Yunpeng, Xiong, Xin, Yang, Huiming, Yin, Peng, Wan, Huida, Chen, Xingxing, Guo, Jifeng, Yan, Xiao-Xin, Liao, Lujian, Li, Shihua, Li, Xiao-Jiang
In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson’s disease (PD). However, difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of PINK1. Here we report that PINK1 kinase form is selectively expressed
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Aging weakens Th17 cell pathogenicity and ameliorates experimental autoimmune uveitis in mice Protein Cell (IF 14.87) Pub Date : 2021-11-08 Li, He, Zhu, Lei, Wang, Rong, Xie, Lihui, Ren, Jie, Ma, Shuai, Zhang, Weiqi, Liu, Xiuxing, Huang, Zhaohao, Chen, Binyao, Li, Zhaohuai, Feng, Huyi, Liu, Guang-Hui, Wang, Si, Qu, Jing, Su, Wenru
Aging-induced changes in the immune system are associated with a higher incidence of infection and vaccination failure. Lymph nodes, which filter the lymph to identify and fight infections, play a central role in this process. However, careful characterization of the impact of aging on lymph nodes and associated autoimmune diseases is lacking. We combined single-cell RNA sequencing (scRNA-seq) with
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Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation Protein Cell (IF 14.87) Pub Date : 2021-11-03 Shi, Guang, Bai, Yaofu, Zhang, Xiya, Su, Junfeng, Pang, Junjie, He, Quanyuan, Zeng, Pengguihang, Ding, Junjun, Xiong, Yuanyan, Zhang, Jingran, Wang, Jingwen, Liu, Dan, Ma, Wenbin, Huang, Junjiu, Songyang, Zhou
Understanding the regulatory networks for germ cell fate specification is necessary to developing strategies for improving the efficiency of germ cell production in vitro. In this study, we developed a coupled screening strategy that took advantage of an arrayed bi-molecular fluorescence complementation (BiFC) platform for protein-protein interaction screens and epiblast-like cell (EpiLC)-induction
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Correction to: A world renowned psychophysiologist: Kaoliang Chow. Protein Cell (IF 14.87) Pub Date : 2022-02-01 Lei Zhang,Lijun Wang,Benyu Guo,Yanyan Qian,Qingming Liu
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Correction to: Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model Protein Cell (IF 14.87) Pub Date : 2021-11-01 Xiaoyan Xu,Yaqin Sun,Xufeng Cen,Bing Shan,Qingwei Zhao,Tingxue Xie,Zhe Wang,Tingjun Hou,Yu Xue,Mengmeng Zhang,Di Peng,Qiming Sun,Cong Yi,Ayaz Najafov,Hongguang Xia
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Hyperthermia differentially affects specific human stem cells and their differentiated derivatives. Protein Cell (IF 14.87) Pub Date : 2021-11-01 Si Wang,Fang Cheng,Qianzhao Ji,Moshi Song,Zeming Wu,Yiyuan Zhang,Zhejun Ji,Huyi Feng,Juan Carlos Izpisua Belmonte,Qi Zhou,Jing Qu,Wei Li,Guang-Hui Liu,Weiqi Zhang
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Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome Protein Cell (IF 14.87) Pub Date : 2021-10-29 Yang, Chaojuan, Tian, Yonglu, Su, Feng, Wang, Yangzhen, Liu, Mengna, Wang, Hongyi, Cui, Yaxuan, Yuan, Peijiang, Li, Xiangning, Li, Anan, Gong, Hui, Luo, Qingming, Zhu, Desheng, Cao, Peng, Liu, Yunbo, Wang, Xunli, Luo, Min-hua, Xu, Fuqiang, Xiong, Wei, Wang, Liecheng, Li, Xiang-yao, Zhang, Chen
Many people affected by fragile X syndrome (FXS) and autism spectrum disorders have sensory processing deficits, such as hypersensitivity to auditory, tactile, and visual stimuli. Like FXS in humans, loss of Fmr1 in rodents also cause sensory, behavioral, and cognitive deficits. However, the neural mechanisms underlying sensory impairment, especially vision impairment, remain unclear. It remains elusive
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"Always learn today, stand ready to act tomorrow"-Po Tien: A pioneer of Virology in China. Protein Cell (IF 14.87) Pub Date : 2021-10-27 Xin Zhang,Huan Liu
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A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis Protein Cell (IF 14.87) Pub Date : 2021-10-23 Ma, Tengfei, Zhao, Liyuan, Zhang, Jie, Tang, Ruofeng, Wang, Xin, Liu, Nan, Zhang, Qian, Wang, Fengyang, Li, Meijiao, Shan, Qian, Yang, Yang, Yin, Qiuyuan, Yang, Limei, Gan, Qiwen, Yang, Chonglin
Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. However, it is not understood how the proper mitochondrial Zn2+ level is achieved to maintain mitochondrial homeostasis. Using Caenorhabditis elegans, we reveal here that a pair of mitochondrion-localized transporters controls the mitochondrial level of Zn2+. We demonstrate
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Drug target inference by mining transcriptional data using a novel graph convolutional network framework Protein Cell (IF 14.87) Pub Date : 2021-10-22 Zhong, Feisheng, Wu, Xiaolong, Yang, Ruirui, Li, Xutong, Wang, Dingyan, Fu, Zunyun, Liu, Xiaohong, Wan, XiaoZhe, Yang, Tianbiao, Fan, Zisheng, Zhang, Yinghui, Luo, Xiaomin, Chen, Kaixian, Zhang, Sulin, Jiang, Hualiang, Zheng, Mingyue
A fundamental challenge that arises in biomedicine is the need to characterize compounds in a relevant cellular context in order to reveal potential on-target or off-target effects. Recently, the fast accumulation of gene transcriptional profiling data provides us an unprecedented opportunity to explore the protein targets of chemical compounds from the perspective of cell transcriptomics and RNA biology
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cGAS guards against chromosome end-to-end fusions during mitosis and facilitates replicative senescence Protein Cell (IF 14.87) Pub Date : 2021-10-22 Li, Xiaocui, Li, Xiaojuan, Xie, Chen, Cai, Sihui, Li, Mengqiu, Jin, Heping, Wu, Shu, Cui, Jun, Liu, Haiying, Zhao, Yong
As a sensor of cytosolic DNA, the role of cyclic GMP-AMP synthase (cGAS) in innate immune response is well established, yet how its functions in different biological conditions remain to be elucidated. Here, we identify cGAS as an essential regulator in inhibiting mitotic DNA double-strand break (DSB) repair and protecting short telomeres from end-to-end fusion independent of the canonical cGAS-STING
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Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332. Protein Cell (IF 14.87) Pub Date : 2021-10-22 Yao Zhao,Chao Fang,Qi Zhang,Ruxue Zhang,Xiangbo Zhao,Yinkai Duan,Haofeng Wang,Yan Zhu,Lu Feng,Jinyi Zhao,Maolin Shao,Xiuna Yang,Leike Zhang,Chao Peng,Kailin Yang,Dawei Ma,Zihe Rao,Haitao Yang
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A tribute to Professor Yong Zhao. Protein Cell (IF 14.87) Pub Date : 2021-10-11 Zheng Tan,Jun Tang,Feng Wang,Xiaocui Li,Yanlian Chen,Zhou Songyang
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New concepts for generating interspecies chimeras using human pluripotent stem cells. Protein Cell (IF 14.87) Pub Date : 2021-10-11 Alejandro De Los Angeles,Jun Wu
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Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells Protein Cell (IF 14.87) Pub Date : 2021-09-29 Mansouri, Maysam, Fussenegger, Martin
Cell therapy approaches that employ engineered mammalian cells for on-demand production of therapeutic agents in the patient’s body are moving beyond proof-of-concept in translational medicine. The therapeutic cells can be customized to sense user-defined signals, process them, and respond in a programmable and predictable way. In this paper, we introduce the available tools and strategies employed
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The Founder of Plant Taxonomy in China: HU Hsen-Hsu. Protein Cell (IF 14.87) Pub Date : 2021-09-26 Xiaojiang Hu,Jinshuang Ma
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An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope Protein Cell (IF 14.87) Pub Date : 2021-09-23 Liu, Zezhong, Xu, Wei, Chen, Zhenguo, Fu, Wangjun, Zhan, Wuqiang, Gao, Yidan, Zhou, Jie, Zhou, Yunjiao, Wu, Jianbo, Wang, Qian, Zhang, Xiang, Hao, Aihua, Wu, Wei, Zhang, Qianqian, Li, Yaming, Fan, Kaiyue, Chen, Ruihong, Jiang, Qiaochu, Mayer, Christian T., Schoofs, Till, Xie, Youhua, Jiang, Shibo, Wen, Yumei, Yuan, Zhenghong, Wang, Kang, Lu, Lu, Sun, Lei, Wang, Qiao
New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a receptor-binding domain (RBD)-binding antibody, XG014, which potently neutralizes β-coronavirus lineage B (β-CoV-B), including SARS-CoV-2, its circulating variants, SARS-CoV and bat SARSr-CoV WIV1
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Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells. Protein Cell (IF 14.87) Pub Date : 2021-09-20 Hezhen Shan,Lingling Geng,Xiaoyu Jiang,Moshi Song,Jianxun Wang,Zunpeng Liu,Xiao Zhuo,Zeming Wu,Jianli Hu,Zhejun Ji,Si Wang,Piu Chan,Jing Qu,Weiqi Zhang,Guang-Hui Liu
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Correction to: Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling Protein Cell (IF 14.87) Pub Date : 2021-09-07 Yuan, Juanjuan, Cai, Ting, Zheng, Xiaojun, Ren, Yangzi, Qi, Jingwen, Lu, Xiaofei, Chen, Huihui, Lin, Huizhen, Chen, Zijie, Liu, Mengnan, He, Shangwen, Chen, Qijun, Feng, Siyang, Wu, Yingjun, Zhang, Zhenhai, Ding, Yanqing, Yang, Wei
A correction to this paper has been published: https://doi.org/10.1007/s13238-021-00833-y
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Persisting lung pathogenesis and minimum residual virus in hamster after acute COVID-19. Protein Cell (IF 14.87) Pub Date : 2021-09-07 Lunzhi Yuan,Huachen Zhu,Ming Zhou,Jian Ma,Rirong Chen,Liuqin Yu,Wenjia Chen,Wenshan Hong,Jia Wang,Yao Chen,Kun Wu,Wangheng Hou,Yali Zhang,Shengxiang Ge,Yixin Chen,Quan Yuan,Qiyi Tang,Tong Cheng,Yi Guan,Ningshao Xia
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Correction to: The nucleocapsid protein of rice stripe virus in cell nuclei of vector insect regulates viral replication Protein Cell (IF 14.87) Pub Date : 2021-09-01 Zhao, Wan, Zhu, Junjie, Lu, Hong, Zhu, Jiaming, Jiang, Fei, Wang, Wei, Luo, Lan, Kang, Le, Cui, Feng
In the original publication of the article Fig. 3A and Fig. 33B were incorrectly published. The correct figures are available in this correction.
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Correction to: Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos Protein Cell (IF 14.87) Pub Date : 2021-08-25 Chen, Chuan, Liu, Wenqiang, Guo, Jiayin, Liu, Yuanyuan, Liu, Xuelian, Liu, Jun, Dou, Xiaoyang, Le, Rongrong, Huang, Yixin, Li, Chong, Yang, Lingyue, Kou, Xiaochen, Zhao, Yanhong, Wu, You, Chen, Jiayu, Wang, Hong, Shen, Bin, Gao, Yawei, Gao, Shaorong
The original article can be found online at https://doi.org/10.1007/s13238-021-00837-8.
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Cancer biology deciphered by single-cell transcriptomic sequencing Protein Cell (IF 14.87) Pub Date : 2021-08-17 Li, Yanmeng, Jin, Jianshi, Bai, Fan
Tumors are complex ecosystems in which heterogeneous cancer cells interact with their microenvironment composed of diverse immune, endothelial, and stromal cells. Cancer biology had been studied using bulk genomic and gene expression profiling, which however mask the cellular diversity and average the variability among individual molecular programs. Recent advances in single-cell transcriptomic sequencing
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The exploration of N6-deoxyadenosine methylation in mammalian genomes Protein Cell (IF 14.87) Pub Date : 2021-08-17 Li, Xuwen, Zhang, Zijian, Luo, Xinlong, Schrier, Jacob, Yang, Andrew D., Wu, Tao P.
N6-methyladenine (N6-mA, m6dA, or 6mA), a prevalent DNA modification in prokaryotes, has recently been identified in higher eukaryotes, including mammals. Although 6mA has been well-studied in prokaryotes, the function and regulatory mechanism of 6mA in eukaryotes are still poorly understood. Recent studies indicate that 6mA can serve as an epigenetic mark and play critical roles in various biological
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Legacy of Hongxi Su: Pioneer of Chinese Cardiosurgery. Protein Cell (IF 14.87) Pub Date : 2021-08-18 Sumin Yang,Haoyu Hu,Xin Zheng,Shizhong Wang,Li Yuan
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Precise genome editing without exogenous donor DNA via retron editing system in human cells. Protein Cell (IF 14.87) Pub Date : 2021-08-17 Xiangfeng Kong,Zikang Wang,Renxia Zhang,Xing Wang,Yingsi Zhou,Linyu Shi,Hui Yang
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The mini player with diverse functions: extracellular vesicles in cell biology, disease, and therapeutics Protein Cell (IF 14.87) Pub Date : 2021-08-10 Thakur, Abhimanyu, Ke, Xiaoshan, Chen, Ya-Wen, Motallebnejad, Pedram, Zhang, Kui, Lian, Qizhou, Chen, Huanhuan Joyce
Extracellular vesicles (EVs) are tiny biological nanovesicles ranging from approximately 30–1000 nm in diameter that are released into the extracellular matrix of most cell types and in biofluids. The classification of EVs includes exosomes, microvesicles, and apoptotic bodies, dependent on various factors such as size, markers, and biogenesis pathways. The transition of EV relevance from that of being
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Nuclear cGAS: sequestration and beyond Protein Cell (IF 14.87) Pub Date : 2021-08-09 Bai, Juli, Liu, Feng
The cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the nucleus where it is associated with distinct nuclear substructures such as
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Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis. Protein Cell (IF 14.87) Pub Date : 2021-08-03 Jinghui Lei,Xiaoyu Jiang,Wei Li,Jie Ren,Datao Wang,Zhejun Ji,Zeming Wu,Fang Cheng,Yusheng Cai,Zheng-Rong Yu,Juan Carlos Izpisua Belmonte,Chunyi Li,Guang-Hui Liu,Weiqi Zhang,Jing Qu,Si Wang
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Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome Protein Cell (IF 14.87) Pub Date : 2021-08-02 Yu-Sheng Chen,Shuaiyao Lu,Bing Zhang,Tingfu Du,Wen-Jie Li,Meng Lei,Yanan Zhou,Yong Zhang,Penghui Liu,Yong-Qiao Sun,Yong-Liang Zhao,Ying Yang,Xiaozhong Peng,Yun-Gui Yang
Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) is an RNA virus of the Coronaviridae family causing the outbreak and worldwide pandemic of coronavirus disease 2019 (COVID-19) (Zhou et al., 2020b; Zhu et al., 2020b). As an emergent and unprecedented global threat to public health, it has affected about 162 million individuals with over 3.3 million deaths until the middle of May. In attributed
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LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells Protein Cell (IF 14.87) Pub Date : 2021-07-31 Sun, Zhen, Yu, Hua, Zhao, Jing, Tan, Tianyu, Pan, Hongru, Zhu, Yuqing, Chen, Lang, Zhang, Cheng, Zhang, Li, Lei, Anhua, Xu, Yuyan, Bi, Xianju, Huang, Xin, Gao, Bo, Wang, Longfei, Correia, Cristina, Chen, Ming, Sun, Qiming, Feng, Yu, Shen, Li, Wu, Hao, Wang, Jianlong, Shen, Xiaohua, Daley, George Q., Li, Hu, Zhang, Jin
LIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs, and few have addressed LIN28’s role within the nucleus. Here, we show that LIN28 displays dynamic temporal and spatial expression
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Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer. Protein Cell (IF 14.87) Pub Date : 2021-07-28 Bing Liu,Daniela Duenas,Li Zheng,Karen Reckamp,Binghui Shen