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Middle meatus microbiome in patients with eosinophilic chronic rhinosinusitis in a Japanese population J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-26 Masanori Kidoguchi, Yoshimasa Imoto, Emiko Noguchi, Takako Nakamura, Wataru Morii, Naoto Adachi, Rieko Ii, Keisuke Koyama, Satoshi Aoki, Keisuke Miyashita, Yu Hosokawa, Kazuhiro Omura, Yasuhiro Tanaka, Kaori Tanaka, Yukio Hida, Takahiro Ninomiya, Yukinori Kato, Masafumi Sakashita, Tetsuji Takabayashi, Shigeharu Fujieda
Background Chronic rhinosinusitis (CRS) is a common chronic inflammatory disease and is subdivided into eosinophilic and noneosinophilic forms. There are few reports investigating the nasal microbiome and its pathological functions in patients with CRS. Objective We sought to analyze factors contributing to variations of the nasal microbiome in CRS, and on the basis of these factors, to elucidate whether
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Refashioning dexpramipexole – a new horizon in eosinophilic asthma? J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-26 Ruth P. Cusack, Ibrahim Sulaiman, Gail M. Gauvreau
Abstract not available
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British Columbia, Canada, as a bellwether for climate-driven respiratory and allergic disorders J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-26 Christopher Carlsten, Michael Brauer, Pat G. Camp, Lorien Nesbitt, Justin Turner
Abstract not available
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PLCG2 associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-26 Kathleen Baysac, Guangping Sun, Hiroto Nakano, Elizabeth G. Schmitz, Anthony C. Cruz, Charles Fisher, Alexis C. Bailey, , Emily Mace, Joshua D. Milner, Michael J. Ombrello
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Widespread monoclonal IgE antibody convergence to an immunodominant, pro-anaphylactic Ara h 2 epitope in peanut allergy J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-23 D. Croote, J.J.W. Wong, C. Pecalvel, E. Leveque, N. Casanovas, J.B.J. Kamphuis, P. Creeks, J. Romero, S. Sohail, D. Bedinger, K.C. Nadeau, R.S. Chinthrajah, L.L. Reber, H.B. Lowman
Background Despite their central role in peanut allergy, human monoclonal IgE antibodies have eluded characterization. Objective We sought to define the sequences, affinities, clonality, and functional properties of human monoclonal IgE antibodies in peanut allergy. Methods We applied our single-cell RNA-sequencing-based SEQ SIFTER™ discovery platform to a set of allergic individuals that varied by
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Community and neighborhood level disparities in extreme climate exposure: implications for asthma and atopic disease outcomes J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-22 Allison J. Burbank, Andre E. Espaillat, Michelle L. Hernandez
Abstract not available
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Inhaled corticosteroid treatment's impact on asthma exacerbations: Influence of human genetics on microbiome composition J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-22 Yu-Jen Chen, Su-Boon Yong
Abstract not available
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Reply J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-22 Javier Perez-Garcia, Maria Pino-Yanes, Fabian Lorenzo-Diaz
Abstract not available
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Nasal epithelial gene expression and total IgE in children and adolescents with asthma J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-22 Zhongli Xu, Erick Forno, Yidan Sun, Michelle Manni, Yueh Ying Han, Soyeon Kim, Molin Yue, Judith M. Vonk, Elin T.M. Kersten, Edna Acosta-Perez, Glorisa Canino, Gerard H. Koppelman, Wei Chen, Juan C. Celedón
Background Little is known about nasal epithelial gene expression and total IgE in youth. Methods We conducted a transcriptome-wide association study (TWAS) of total IgE in 469 Puerto Ricans aged 9-20 years who participated in the Epigenetic Variation and Childhood Asthma in Puerto Rico (EVA-PR) study, separately in all subjects and in those with asthma. We then attempted to replicate top findings
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Reply J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-20 Paul Leong, James H. Hull, Peter G. Gibson, Thomas Halvorsen, Philip G. Bardin
Abstract not available
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Health-based strategies for overcoming barriers to climate change adaptation and mitigation J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-22 Patrick L. Kinney, Beverly Ge, Vanitha Sampath, Kari Nadeau
Climate change poses an unequivocal threat to the respiratory health of current and future generations. Human activities—largely through the release of greenhouse gases (GHGs)—are driving rising global temperatures. Without a concerted effort to mitigate GHG emissions or adapt to the effects of a changing climate, each increment of warming increases the risk of climate hazards (e.g. heat waves, floods
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Climate change is a health crisis with opportunities for healthcare action: A focus on healthcare providers, patients with asthma and allergic immune diseases, their families and neighbors J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-22 Nicholas J. Nassikas, Diane R. Gold
Climate change has increased the frequency of extreme weather events and compounded natural disasters. Heat, wildfires, flooding and pollen are already threatening public health and disproportionately affecting individuals in susceptible situations and vulnerable locations. In this special issue of JACI, we address what is known and not known about the biologic as well as clinical upstream and downstream
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Climate change and epigenetic biomarkers in allergic and airway diseases J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-22 Andres Cardenas, Raj Fadadu, Supinda Bunyavanich
Human epigenetic variation is associated with both environmental exposures and allergic diseases and can potentially serve as a biomarker connecting climate change with allergy and airway diseases. In this narrative review, we summarize recent human epigenetic studies examining exposure to temperature, precipitation, extreme weather events, and malnutrition to discuss findings as they relate to allergic
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Fungal Allergen Sensitization: Prevalence, Risk Factors and Geographic Variation in the United States J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-21 Kenny Kwong, Matthew Robinson, Adam Sullivan, Stanley Letovsky, Andrew H. Liu, Andre Valcour
Background Many fungal species are associated with the pathogenesis of allergic disease, yet most epidemiologic studies on IgE-mediated fungal sensitization have only included a few species. Objective To investigate fungal allergen sensitization prevalence, risk factors and geographic variation in the United States. Methods From 2014-2019, 7,912,504 serum specific IgE (sIgE) test results for 17 fungal
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The SARS-CoV-2 Pandemic and Asthma: What We Have Learned and What is still Unknown J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-20 Christa McPhee, Kateryna Yevdokimova, Linda Rogers, Monica Kraft
The SARS-CoV-2 pandemic has brought new insights into the immunological intricacies of asthma. In this review, we discuss the epidemiology of asthma in patients infected with SARS-CoV-2 and the risk of severe infection. Type 2 inflammation had an overall protective effect against SARS-CoV-2 infection by various mechanisms summarized in this review. Asthma, intranasal, and inhaled corticosteroids decreased
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VCD and ILO are not synonymous J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-20 Miles Weinberger
Abstract not available
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Increasing wildfire smoke from the climate crisis: Impacts on asthma and allergies J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-20 John R. Balmes, Stephanie M. Holm
Abstract not available
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Molecular pathways underlying lung-brain axis signaling in asthma: relevance for psychopathology and neuroinflammation J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-19 Kimberly A. Dill-McFarland, Matthew C. Altman, Stephane Esnault, Nizar N. Jarjour, William W. Busse, Melissa A. Rosenkranz
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The role of glycosylation in clinical allergy and immunology J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-17 Rebecca C. Hale, Dominique Morais, Janet Chou, Sean R. Stowell
While glycans are among the most abundant macromolecules on the cell with widespread functions, their role in immunity has historically been challenging to study. This is in part due to difficulties assimilating glycan analysis into routine approaches used to interrogate immune cell function. Despite this, recent developments have illuminated fundamental roles for glycans in host immunity. The growing
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The Spectrum of Environmental Disparities in Asthma J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-15 Anna M. Zhang, Tina M. Banzon, Wanda Phipatanakul
Abstract not available
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Human PLCG2 Haploinsufficiency Results in a Novel NK Cell Immunodeficiency J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-13 Joshua B. Alinger, Emily M. Mace, Justin.R. Porter, Annelise Y. Mah-Som, Allyssa L. Daugherty, Stephanie Li, Allison A. Throm, Jeanette T. Pingel, Nermina Saucier, Albert Yao, Ivan K. Chinn, James R. Lupski, Mohammad Ehlayel, Michael Keller, Greg R. Bowman, Megan A. Cooper, Jordan S. Orange, Anthony R. French
Background Although most individuals effectively control herpesvirus infections, some suffer from severe and/or recurrent infections. A subset of these patients possess defects in NK cells, lymphocytes which recognize and lyse herpesvirus-infected cells; however, the genetic etiology is rarely diagnosed. PLCG2 encodes a signaling protein in NK cell and B cell signaling. Dominant- negative or gain-of-function
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Gut microbiome is associated with asthma and race in children with food allergy. J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-14 Mahboobeh Mahdavinia, John P. Fyolek, Jialing Jiang, Neil Thivalapill, Lucy A. Bilaver, Christopher Warren, Susan Fox, Sai R. Nimmagadda, Pamela J. Newmark, Hemant Sharma, Amal Assa’ad, Patrick C. Seed, Ruchi S. Gupta
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Genome-wide meta-analysis implicates variation affecting mast cell biology in urticaria J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-09 Sheila Mary McSweeney, Jake Saklatvala, Rossella Rispoli, Clarisse Ganier, Grzegorz Woszczek, Laurent Thomas, Kristian Hveem, Mari Løset, Nick Dand, Christos Tziotzios, Michael Simpson, John Alexander McGrath
Background Urticaria is characterized by inappropriate mast cell degranulation that leads to the development of wheals and/or angioedema. Twin and family studies indicate that there is a substantial heritable component to urticaria risk. Objective To identify genomic loci at which common genetic variation influence urticaria susceptibility. Methods Genome-wide association studies (GWAS) of urticaria
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Systemic treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-09 Alexandro W.L. Chu, Melanie M. Wong, Daniel G. Rayner, Gordon H. Guyatt, Juan Pablo Díaz Martinez, Renata Ceccacci, Irene X. Zhao, Eric McMullen, Archita Srivastava, Jason Wang, Aaron Wen, Fang Chi Wang, Romina Brignardello-Petersen, Ariel Izcovich, Paul Oykhman, Kathryn E. Wheeler, Julie Wang, Jonathan M. Spergel, Jasvinder A. Singh, Jonathan I. Silverberg, Derek K. Chu
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Topical treatments for atopic dermatitis (eczema): systematic review and network meta-analysis of randomized trials J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-09 Derek K. Chu, Alexandro W.L. Chu, Daniel G. Rayner, Gordon H. Guyatt, Juan José Yepes-Nuñez, Luis Gomez-Escobar, Lucia C. Pérez-Herrera, Juan Pablo Díaz Martinez, Romina Brignardello-Petersen, Behnam Sadeghirad, Melanie M. Wong, Renata Ceccacci, Irene X. Zhao, John Basmaji, Margaret MacDonald, Xiajing Chu, Nazmul Islam, Ya Gao, Ariel Izcovich, Rachel N. Asiniwasis, Lynda Schneider
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Severe adult haemophagocytic lymphohistiocytosis (HLHa) correlates with HLH-related gene variants J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-09 Coralie Bloch, Jean Philippe Jais, Marine Gil, Marouane Boubaya, Yves Lepelletier, Brigitte Bader-Meunier, Nizar Mahlaoui, Nicolas Garcelon, Olivier Lambotte, David Launay, Claire Larroche, Estibaliz Lazaro, Francois Liffermann, Olivier Lortholary, Marc Michel, Jean-Marie Michot, Pierre Morel, Morgane Cheminant, Felipe Suarez, Louis Terriou, Olivier Hermine
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IFN-γ ELISpot-enabled machine learning for culprit drug identification in non-immediate drug hypersensitivity J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-09 Yuda Chongpison, Sira Sriswasdi, Supranee Buranapraditkun, Pattarawat Thantiworasit, Pawinee Rerknimitr, Pungjai Mongkolpathumrat, Leena Chularojanamontri, Yuttana Srinoulprasert, Ticha Rerkpattanapipat, Kumutnart Chanprapaph, Wareeporn Disphanurat, Panlop Chakkavittumrong, Napatra Tovanabutra, Chutika Srisuttiyakorn, Chonlaphat Sukasem, Papapit Tuchinda, Padcha Pongcharoen, Jettanong Klaewsongkram
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Impact of newborn screening for SCID on the management of congenital athymia J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-09 Evey Howley, Zainab Golwala, Matthew Buckland, Federica Barzaghi, Sujal Ghosh, Scott Hackett, Rosie Hague, Fabian Hauck, Ursula Holzer, Adam Klocperk, Minna Koskenvuo, Nufar Marcus, Antonio Marzollo, Malgorzata Pac, Jan Sinclair, Carsten Speckmann, Maarja Soomann, Lynne Speirs, Sneha Suresh, Sophie Taque, Alexandra Y. Kreins
Background Newborn screening (NBS) programmes for severe combined immunodeficiency (SCID) facilitate early SCID diagnosis and promote early treatment with haematopoietic stem cell transplantation, resulting in improved clinical outcomes. Infants with congenital athymia are also identified through NBS due to severe T-cell lymphopaenia. With the expanding introduction of NBS programmes, referrals of
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Global warming and implications for epithelial barrier disruption and respiratory and dermatologic allergic diseases J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-09 Zeynep Çelebi Sözener, Elsa R. Treffeisen, Betül Özdel Öztürk, Lynda C. Schneider
Global warming has direct and indirect effects, as well as short- and long-term impacts on the respiratory and skin barriers. Extreme temperature directly affects the airway epithelial barrier by disrupting the structural proteins and by triggering airway inflammation and hyperreactivity. It enhances tidal volume and respiratory rate by affecting the thermoregulatory system, causing specific airway
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E-cigarette vapour renders neutrophils dysfunctional due to filamentous actin accumulation J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-05 Alice E. Jasper, Aduragbemi A. Faniyi, Lauren C. Davis, Frances S. Grudzinska, Robyn Halston, Jon Hazeldine, Dhruv Parekh, Elizabeth Sapey, David R. Thickett, Aaron Scott
Background Electronic (e-)cigarette use continues to rise despite concerns of long-term effects, especially the risk of developing lung diseases such as chronic obstructive pulmonary disease (COPD). Neutrophils are central to the pathogenesis of COPD, with changes in phenotype and function implicated in tissue damage. Objective This study aimed to measure the impact of direct exposure to nicotine containing
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Brief Overview of This Month's JACI J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-05
Abstract not available
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Information for Readers J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-05
Abstract not available
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In lasting tribute: K. Frank Austen, March 14, 1928, to June 23, 2023 J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-05 Joshua A. Boyce, Allen Kaplan, Dean D. Metcalfe, Stephen Wasserman, Arlene Stolper Simon
Abstract not available
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The Editors’ Choice J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-05
Abstract not available
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News beyond our pages J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-05 Marc E. Rothenberg, Jean Bousquet
Abstract not available
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Breakthroughs in understanding and treating eosinophilic gastrointestinal diseases presented at the CEGIR/TIGERs Symposium at the 2022 American Academy of Allergy, Asthma & Immunology Meeting J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-03 Mirna Chehade, Benjamin L. Wright, Dan Atkins, Seema S. Aceves, Steven J. Ackerman, Amal H. Assa’ad, Maureen Bauer, Margaret H. Collins, Scott P. Commins, Carla M. Davis, Evan S. Dellon, Bethan Doerfler, Gerald J. Gleich, Sandeep K. Gupta, David A. Hill, Elizabeth T. Jensen, David Katzka, Kara Kliewer, Ellyn Kodroff, Leah C. Kottyan, Marc E. Rothenberg
The Consortium of Eosinophilic Gastrointestinal Diseases (CEGIR) and The International Gastrointestinal Eosinophil Researchers (TIGERs) organized a day-long symposium at the 2022 Annual Meeting of the American Academy of Allergy, Asthma & Immunology. The symposium featured a review of recent discoveries in the basic biology and pathogenesis of eosinophilic gastrointestinal diseases (EGIDs) in addition
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Dupilumab strengthens HSV-1 specific immune responses in atopic dermatitis J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-01 Stephan Traidl, Leonard Harries, Petra Kienlin, Gabriele Begemann, Lennart M. Roesner, Thomas Werfel
Background Impaired viral clearance in a subgroup of atopic dermatitis (AD) patients can lead to severe herpes simplex virus (HSV) infections named eczema herpeticum (EH). We recently identified a type 2 skewed viral immune response in EH patients. Clinical data suggest a reduced incidence of EH in AD patients treated with dupilumab, however, immunological investigations of this phenomenon are still
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Intestinal microbiome and metabolome signatures in patients with chronic granulomatous disease. J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-01 Prabha Chandrasekaran, Yu Han, Christa S. Zerbe, Theo Heller, Suk See DeRavin, Samantha A. Kreuzberg, Beatriz E. Marciano, Yik Siu, Drew R. Jones, Roshini S. Abraham, Michael C. Stephens, Amy M. Tsou, Scott Snapper, Sean Conlan, Poorani Subramanian, Mariam Quinones, Caroline Grou, Virginie Calderon, Clayton Deming, Jennifer W. Leiding, Emilia Liana Falcone
Background CGD is caused by defects in any of the 6 subunits forming the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex 2 (NOX2), leading to severely reduced or absent phagocyte-derived ROS production. Almost 50% of patients with chronic granulomatous disease (CGD) have IBD (CGD-IBD). While conventional IBD therapies can treat CGD-IBD, their benefits must be weighed against the
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Patient-reported outcome measures for urticaria and angioedema J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-09-01 Pedro C. Avila
Abstract not available
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IL-13-induced STAT3-dependent signaling networks regulate esophageal epithelial proliferation in eosinophilic esophagitis. J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-29 Sahiti Marella, Ankit Sharma, Varsha Ganesan, Daysha Ferrer-Torres, James Krempski, Gila Idelman, Sydney Clark, Zena Nasiri, Simone Vanoni, Chang Zeng, Andrej A. Dlugosz, Haibin Zhou, Shaomeng Wang, Alfred D. Doyle, Benjamin L. Wright, Jason Spence, Mirna Chehade, Simon P. Hogan
Background Basal zone hyperplasia (BZH) and dilated intercellular spaces (DIS) are thought to contribute to the clinical manifestations of Eosinophilic esophagitis (EoE); however, the molecular pathways that drive BZH remain largely unexplored. Objective To define the role of IL-13-induced transcriptional programs in esophageal epithelial proliferation in EoE. Methods We performed RNA sequencing, bioinformatics
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US Drug Allergy Registry (USDAR) grading scale for immediate drug reactions J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-29 David A. Khan, Elizabeth J. Phillips, John J. Accarino, Alexei Gonzalez-Estrada, Iris M. Otani, Allison Ramsey, Anna Chen Arroyo, Aleena Banerji, Timothy Chow, Anne Liu, Cosby A. Stone, Kimberly G. Blumenthal
Background There is no accepted grading system classifying the severity of immediate reactions to drugs. Objective The purpose of this article is to present a proposed grading system developed through the consensus of drug allergy experts from the US Drug Allergy Registry (USDAR) Consortium. Methods The USDAR investigators sought to develop a consensus severity grading system for immediate drug reactions
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Single-cell transcriptomics reveals granzyme K-expressing cytotoxic Tfh cells in tertiary lymphoid structures in IgG4-RD J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-29 Ryuichi Aoyagi, Takashi Maehara, Risako Koga, Ryusuke Munemura, Tadashi Tomonaga, Yuka Murakami, Atsushi Doi, Hidetaka Yamamoto, Tamotsu Kiyoshima, Shintaro Kawano, Seiji Nakamura
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Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-25 Brian Kim, Marc E. Rothenberg, Xin Sun, Claus Bachert, David Artis, Raza Zaheer, Yamo Deniz, Paul Rowe, Sonya Cyr
Type 2 inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators and cells that drive neuroimmune activation and sensitization to previously sub-threshold stimuli. The consequences of altered neuroimmune activity differ with tissue type and disease and include: skin inflammation, sensitization to pruritogens, and itch amplification in atopic dermatitis and
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An elevated prevalence of hereditary alpha-tryptasemia in all mastocytosis subtypes: pathophysiological implications J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-24 Laura Polivka, Marine Madrange, Cristina Bulai-Livideanu, Stephane Barete, Thomas Ballul, Antoine Neuraz, Celine Greco, Julie Agopian, Fabienne Brenet, Patrice Dubreuil, Charles Burdet, Richard Lemal, Olivier Tournilhac, Louis Terriou, David Launay, Laurence Bouillet, Clément Gourguechon, Ghandi Damaj, Laurent Frenzel, Cecile Meni, Julien Rossignol
Background Mastocytosis and monoclonal mast cell (MC) activation syndrome (MMAS) are heterogeneous conditions characterized by the accumulation of atypical MCs. Despite the recurrent involvement of KIT mutations, the pathophysiological origin of mastocytosis and MMAS is unclear. Although hereditary α-tryptasemia (HαT, related to TPSAB1 gene duplication) is abnormally frequent in these diseases, it
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Dupilumab as a novel treatment option for prurigo nodularis J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-23 Saeko Nakajima, Satoru Yonekura, Satoshi Nakamizo, Gyohei Egawa, Kenji Kabashima
Abstract not available
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Viral infections and chronic rhinosinusitis J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-22 Sophia Volpe, Joseph Irish, Sunny Palumbo, Eric Lee, Jacob Herbert, Ibrahim Ramadan, Eugene H. Chang
Viral infections are the most common cause of upper respiratory infections; they frequently infect adults once or twice and children 6 to 8 times annually. In most cases, these infections are self-limiting and resolve. However, many patients with chronic rhinosinusitis (CRS) relay that their initiating event began with an upper respiratory infection that progressed in both symptom severity and duration
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Longitudinal dynamics of the gut microbiome and metabolome in peanut allergy development J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-22 Yoojin Chun, Alexander Grishin, Rebecca Rose, William Zhao, Zoe Arditi, Lingdi Zhang, Robert A. Wood, A. Wesley Burks, Stacie M. Jones, Donald Y.M. Leung, Drew R. Jones, Hugh A. Sampson, Scott H. Sicherer, Supinda Bunyavanich
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Childhood Respiratory Viral Infections and the Microbiome J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-20 Kirsten M. Kloepfer, Joshua L. Kennedy
The human microbiome associated with the respiratory tract is diverse, heterogeneous, and dynamic. The diversity and complexity of the microbiome and the interactions between microorganisms, host cells, and the host immune system are complex and multifactorial. Furthermore, the lymphatics provide a direct highway, the gut-lung axis, for the gut microbiome to affect outcomes related to respiratory disease
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Progress in Understanding if Respiratory Syncytial Virus Infection in Infancy Causes Asthma in Childhood J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-19 Christian Rosas-Salazar, Kohei Hasegawa, Tina V. Hartert
Abstract not available
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Functional immunophenotyping of blood neutrophils identifies novel endotypes of viral response in preschool children with recurrent wheezing J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-19 Anne M. Fitzpatrick, Ahmad F. Mohammad, Min Huang, Susan T. Stephenson, James Patrignani, Rishikesan Kamaleswaran, Jocelyn R. Grunwell
Background Preschool children with recurrent wheezing are heterogeneous, with differing responses to respiratory viral infections. Although neutrophils are crucial for host defense, their function has not been studied in this population. Objective We performed functional immunophenotyping on isolated blood neutrophils from 52 preschool children with recurrent wheezing (aeroallergen sensitization, n=16;
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Identification of cow milk epitopes to characterize and quantify disease-specific T cells in allergic children J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-19 Sloan A. Lewis, Aaron Sutherland, Ferran Soldevila, Luise Westernberg, Minori Aoki, April Frazier, Synaida Maiche, Mich Erlewyn-Lajeunesse, Hasan Arshad, Stephanie Leonard, Susan Laubach, Jennifer A. Dantzer, Robert A. Wood, Alessandro Sette, Gregory Seumois, Pandurangan Vijayanand, Bjoern Peters
Background Cow milk (CM) allergy is the most prevalent food allergy in young children in the US and Great Britain. Current diagnostic tests are either unreliable (IgE, skin prick test), or resource-intensive with risks (food challenges). Objective Here we set out to determine if allergen-specific T cells in cow milk allergic (CMA) patients have a distinct quality and/or quantity that could potentially
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Pharmacokinetics/Pharmacodynamics of Epinephrine After Single and Repeat Administration of neffy, EpiPen, and Manual Intramuscular Injection J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-19 Thomas B. Casale., Anne K. Ellis, Anna Nowak-Wegrzyn, Michael Kaliner, Richard Lowenthal, Sarina Tanimoto
Background Epinephrine is the first line treatment for severe allergic reactions, and rapid treatment is associated with lower rates of hospitalization and death. Current treatment options (epinephrine auto-injectors and manual intramuscular injection) are considered cumbersome and most patients/caregivers fail to use them, even during severe reactions. An intranasal epinephrine delivery device, neffy
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Mucosal IgA immune complex induces immunomodulatory responses in allergic airway and intestinal Th2 disease J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-19 Srikanth Elesela, Llilian Arzola-Martínez, Andrew Rasky, Catherine Ptaschinski, Simon P. Hogan, Nicholas W. Lukacs
Background IgA is the most abundant Immunoglobulin at the mucosal surface and its role in regulating mucosal immunity is not fully understood, but its presence is associated with protection from developing allergic disease. Objective Determine the role of IgA immune complexes for therapeutic application to mucosal allergic responses. Methods Apply TNP specific IgA immune complexes, using TNP coupled
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The opposing effects of two gene-defects in STX11 and SLP76 on the disease in a patient with an Inborn Error of Immunity J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-16 Rana Mansour, Rana El-Hassan, Youmna El-Orfali, Adam Saidu, Habib Al-Kalamouni, Qian Chen, Mehdi Benamar, Ghassan Dbaibo, Rima Hanna-Wakim, Talal Chatila, Michel J. Massaad
Background Inborn errors of immunity are mostly monogenic. However, disease phenotype and outcome may be modified by the co-existence of a second gene defect. Objective To identify the genetic basis of the disease in a patient who suffered from bleeding episodes, pancytopenia, hepatosplenomegaly, and recurrent pneumonia that resulted in death. Methods Genetic analysis was done using next generation
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Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance. J. Allergy Clin. Immunol. (IF 14.2) Pub Date : 2023-08-16 Timothy R. O’Meara, Etsuro Nanishi, Marisa E. McGrath, Soumik Barman, Danica Dong, Carly Dillen, Manisha Menon, Hyuk-Soo Seo, Sirano Dhe-Paganon, Robert K. Ernst, Ofer Levy, Matthew B. Frieman, David J. Dowling