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Clinical Exome Sequencing of 1000 Families with Complex Immune Phenotypes: Towards comprehensive genomic evaluations J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-24 Morgan N. Similuk, Jia Yan, Rajarshi Ghosh, Andrew J. Oler, Luis M. Franco, Michael Setzer, Michael Kamen, Colleen Jodarski, Thomas DiMaggio, Joie Davis, Rachel Gore, Leila Jamal, Adrienne Borges, Nicole Gentile, Julie Niemela, Chenery Lowe, Kathleen Jevtich, Yunting Yu, Magdalena A. Walkiewicz
Background Prospective genetic evaluation of patients at our referral research hospital presents clinical research challenges. Objective This study sought not only a single-gene explanation for participants’ immune-related presentations, but viewed each participant holistically, with the potential to have multiple genetic contributions to their immune-phenotype and other heritable comorbidities relevant
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Human IgE mAbs Identify Major Antigens of Parasitic Worm Infection J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-24 Azadeh Hadadianpour, Jacob Daniel, Jian Zhang, Benjamin W. Spiller, Asta Makaraviciute, Åsa M. DeWitt, Heather S. Walden, Robert G. Hamilton, R. Stokes Peebles, Thomas B. Nutman, Scott A. Smith
Rationale Much of our understanding of the targets of IgE comes from studies of allergy, though little is known about the natural immunogenic targets seen following parasitic worm infections. The use of human monoclonal antibodies (mAbs) allow for an unbiased, comprehensive characterization of the immunodominant antigens targeted by IgE in conditions (e.g., allergy, helminth infection) associated with
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STAT3-confusion-of-function: beyond the loss and gain dualism. J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-21 Lorenzo Lodi, Laura Eva Faletti, Maria Elena Maccari, Filippo Consonni, Miriam Groß, Ilaria Pagnini, Silvia Ricci, Maximilian Heeg, Gabriele Simonini, Chiara Azzari, Stephan Ehl
Background Germline mutations of signal transducer and activator of transcription 3 (STAT3) are responsible for two distinct human diseases: autosomal-dominant hyper-immunoglobulin E syndrome (AD-HIES) caused by STAT3 loss-of-function (STAT3-LOF) mutations and STAT3 gain-of-function (STAT3-GOF) disease. So far, these entities have been regarded as antithetic, with AD-HIES mainly associated with characteristic
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Art v 1 IgE epitopes of patients and humanized mice are conformational J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-21 Maja Zabel, Milena Weber, Bernhard Kratzer, Cordula Köhler, Beatrice Jahn-Schmid, Gabriele Gadermaier, Pia Gattinger, Urška Bidovec-Stojkovič, Peter Korošec, Ursula Smole, Gert Wurzinger, Kuan-Wei Chen, Carmen Bunu Panaitescu, Ludger Klimek, Isabel Pablos, Katarzyna Niespodziana, Alina Neunkirchner, Walter Keller, Winfried F. Pickl
Background Worldwide, pollen of the weed mugwort (Artemisia vulgaris) is a major cause of severe respiratory allergy, with its major allergen, Art v 1, being the key pathogenic molecule for millions of patients. Humanized mice transgenic for a human T-cell receptor specific for the major Art v 1 T-cell epitope and the corresponding HLA have been made. Objective We sought to characterize IgE epitopes
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DJ-1 governs airway progenitor cell/eosinophil interactions to promote allergic inflammation J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-18 Kuan Li, Qiuyang Zhang, Li Li, Shuangyan Li, Qing Yue, Xue Li, Yu Li, Jianhai Wang, Sisi Wang, Zengqiang Yuan, Huaiyong Chen
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Normal B cell ranges in infants: A systematic review and meta-analysis J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-18 Francesco Borriello, Noemi Pasquarelli, Lisa Law, Kim Rand, Catarina Raposo, Wei Wei, Licinio Craveiro, Tobias Derfuss
Background During the first year of life, B cell level is a valuable indicator of whether external factors, such as exposure to B cell depleting therapies, have an adverse impact on immune system development. However, there are no standard reference ranges of B cell levels in healthy infants by age. Objective To estimate the normal range of B cell levels in infants, by age, during the first year of
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Retinoic acid promotes fibrinolysis and may regulate polyp formation J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-18 Masafumi Sakashita, Tetsuji Takabayashi, Yoshimasa Imoto, Tetsuya Homma, Kanako Yoshida, Kazuhiro Ogi, Yukihiro Kimura, Atsushi Kato, Whitney Stevens, Stephanie Shintani Smith, Kevin Welch, James E. Norton, Lydia A. Suh, Roderick G. Carter, Kathryn E. Hulse, Sudarshan Seshadri, Jin-Young Min, Kathryn L. Pothoven, Robert P. Schleimer
Background Aspirin-exacerbated respiratory disease (AERD) patients regularly exhibit severe nasal polyposis. Studies suggest that chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by excessive fibrin deposition associated with a profound decrease in epithelial tissue plasminogen activator (tPA). Retinoids, including vitamin A and its active metabolite retinoic acid (RA), are necessary
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Blood endotypic signature in atopic dermatitis: the challenge in personalized medicine J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-18 Tom C. Chan, Chia-Yu Chu
Abstract not available
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Epigenetic regulation of immune function in asthma J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-16 Sunita Sharma, Ivana V. Yang, David A. Schwartz
Asthma is a common complex respiratory disease characterized by chronic airway inflammation and partially reversible airflow obstruction resulting from genetic and environmental determinants. Because epigenetic marks influence gene expression and can be modified by both environmental exposures and genetic variation, they are increasingly recognized as relevant to the pathogenesis of asthma and may
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Kinetics of basophil hyporesponsiveness during short-course peanut OIT J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-16 Michael D. Kulis, Johanna M. Smeekens, Caitlin Burk, Xiaohong Yue, Rishu Guo, Kelly A. Orgel, Ping Ye, Lauren Herlihy, Deanna Hamilton, Quefeng Li, Corinne Keet, Wayne Shreffler, Brian P. Vickery, A. Wesley Burks, Edwin H. Kim
Background Oral immunotherapy (OIT) leads to suppression of mast cell and basophil degranulation along with changes in the adaptive immune response. Objective We aimed to determine how rapidly these effects occur during OIT and more broadly, the kinetics of basophil and mast cell suppression throughout the course of therapy. Methods Twenty participants, aged 4-12, were enrolled in a peanut OIT trial
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Does Shining a Spotlight on XIAP Deficiency Bring the Role of Allogeneic HCT into Better Focus? J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-16 Rebecca A. Marsh
Abstract not available
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Pre-existing comorbidities shape the immune response associated with severe COVID-19 J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-16 Stefanie Kreutmair, Manuel Kauffmann, Susanne Unger, Florian Ingelfinger, Nicolás Gonzalo Núñez, Chiara Alberti, Donatella De Feo, Sinduya Krishnarajah, Ekaterina Friebel, Can Ulutekin, Sepideh Babaei, Benjamin Gaborit, Mirjam Lutz, Nicole Puertas Jurado, Nisar P. Malek, Siri Göpel, Peter Rosenberger, Helene A. Häberle, Burkhard Becher
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Examination of host genetic effects on nasal microbiome composition J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-16 Haritz Irizar, Yoojin Chun, Zoe Arditi, Anh Do, Galina Grishina, Alexander Grishin, Alfin Vicencio, Supinda Bunyavanich
Background Genetic predisposition increases risk for asthma, and distinct nasal microbial compositions are associated with asthma. Host genetics might shape nasal microbiome composition. Objective We examined associations between host genetics and nasal microbiome composition. Methods Nasal samples were collected from 584 participants from the Mount Sinai Health System, New York, USA. Seventy-seven
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Filaggrin loss-of-function mutations are associated with persistence of egg and milk allergy J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-15 Birgit Kalb, Ingo Marenholz, Alexander CSN. Jeanrenaud, Lara Meixner, Aleix Arnau-Soler, Oscar D. Rosillo-Salazar, Ahla Ghauri, Penelope Cibin, Katharina Blümchen, Rupert Schlags, Gesine Hansen, Jürgen Seidenberg, Thomas Keil, Susanne Lau, Bodo Niggemann, Kirsten Beyer, Young-Ae Lee
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Introducing thymus for promoting transplantation tolerance J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-09 Zachary W. Fitch, Lillian Kang, Jie Li, Stuart J. Knechtle, Joseph W. Turek, Allan D. Kirk, M. Louise Markert, Jean Kwun
Establishing tolerance remains a central, if elusive, goal of transplantation. In solid-organ transplantation, one strategy for inducing tolerance has been cotransplantation of various forms of thymic tissue along with another organ. As one of the biological foundations of central tolerance, thymic tissue carries with it the ability to induce tolerance to any other organ or tissue from the same donor
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Reproducibility of food challenge to cow’s milk: a systematic review with individual participant data meta-analysis J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-07 Paul J. Turner, Nandinee Patel, Dianne E. Campbell, Hugh A. Sampson, Mayu Maeda, Toshio Katsunuma, Joost Westerhout, W. Marty Blom, Joseph L. Baumert, Geert F. Houben, Benjamin C. Remington
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Identification of novel genes influencing eosinophil-specific protein levels in asthma families J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-06 Raphaël Vernet, Régis Matran, Farid Zerimech, Anne-Marie Madore, Marie-Eve Lavoie, Pierre-Alexandre Gagnon, Hamida Mohamdi, Patricia Margaritte-Jeannin, Valérie Siroux, Marie-Hélène Dizier, Florence Demenais, Catherine Laprise, Rachel Nadif, Emmanuelle Bouzigon
Background Eosinophils play a key role in the asthma allergic response by releasing cytotoxic molecules such as eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN) that generate epithelium damages. Objective To identify genetic variants influencing ECP and EDN levels in asthma-ascertained families. Methods We performed univariate and bivariate genome-wide association analyses
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Chronic Rhinosinusitis: Future Treatments and Unmet Needs J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03 Sneha Giri, Alexander Schneider, Bruce Tan
Abstract not available
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Insights into the Biology of IL-9 in Asthma J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-02 Taylor A. Doherty, David H. Broide
Abstract not available
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Risk factors for SARS-CoV-2 infection and transmission in households with asthmatic and allergic children. A prospective surveillance study J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-01 Max A. Seibold, Camille M. Moore, Jamie L. Everman, Blake J.M. Williams, James D. Nolin, Ana Fairbanks-Mahnke, Elizabeth G. Plender, Bhavika B. Patel, Samuel J. Arbes, Leonard B. Bacharier, Casper G. Bendixsen, Agustin Calatroni, Carlos A. Camargo, William D. Dupont, Glenn T. Furuta, Tebeb Gebretsadik, Rebecca S. Gruchalla, Ruchi S. Gupta, Tina V. Hartert
Background Whether children and people with asthma and allergic diseases are at increased risk for SARS-CoV-2 infection is unknown. Objective To determine SARS-CoV-2 infection incidence in households with children, and whether self-reported asthma and/or other allergic diseases are associated with infection and household transmission. Methods Biweekly nasal swabs and weekly surveys were conducted for
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Cystatin SN is a Potent Upstream Initiator of Epithelial Derived Type 2 Inflammation in Chronic Rhinosinusitis J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-31 Angela L. Nocera, Sarina K. Mueller, Alan D. Workman, Dawei Wu, Kristen McDonnell, Peter M. Sadow, Mansoor M. Amiji, Benjamin S. Bleier
Background Cystatin SN/SA (CST1/2) are cysteine protease inhibitors which protect against allergen, viral, and bacterial proteases. Cystatins are overexpressed in the setting of allergic rhinitis and chronic rhinosinusitis with nasal polyps (CRSwNP), however, their role in promoting type 2 inflammation remains poorly characterized. Objective The purpose of this study was to use integrated poly-omics
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Brief Overview of This Month's JACI J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03
Abstract not available
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Table of Contents J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03
Abstract not available
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Information for Readers J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03
Abstract not available
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CME Calendar-AAAAI J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03
Abstract not available
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Autoimmune chronic spontaneous urticaria J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03 Pavel Kolkhir, Melba Muñoz, Riccardo Asero, Marta Ferrer, Emek Kocatürk, Martin Metz, Yi-Kui Xiang, Marcus Maurer
Chronic spontaneous urticaria (CSU) is a debilitating mast cell–driven disease characterized by recurrent wheals and/or angioedema. Substantial progress has been made in dissecting the 2 main autoimmune mechanisms that drive the pathogenesis of CSU. Type I autoimmune (autoallergic) CSU is associated with IgE antibodies against autoantigens, for example, thyroid peroxidase and IL-24. Type IIb autoimmune
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Autoimmune chronic spontaneous urticaria J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03
Abstract not available
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The Editors’ Choice J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03
Abstract not available
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News Beyond Our Pages J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-06-03 Marc E. Rothenberg, Jean Bousquet
Abstract not available
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Endotyping pediatric obesity-related asthma: contribution of anthropometrics, metabolism, nutrients, and CD4+ lymphocytes, to pulmonary function J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-30 David Thompson, Lisa G. Wood, Evan J. Williams, Rebecca F. McLoughlin, Deepa Rastogi
Background Obesity-related complications including visceral fat, metabolic abnormalities, nutrient deficiencies, and immune perturbations are interdependent but have been individually associated with childhood asthma. Objective To endotype childhood obesity-related asthma by quantifying contributions of obesity-related complications to symptoms and pulmonary function. Methods Multi-omics analysis using
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Eosinophilic gastrointestinal diseases make a name for themselves: A new consensus statement with updated nomenclature J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-29 Benjamin L. Wright, Justin T. Schwartz, Melanie A. Ruffner, Glenn T. Furuta, Nirmala Gonsalves, Evan S. Dellon, Seema S. Aceves
Abstract not available
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Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-25 Xiaofan Tu, Richard Y. Kim, Alexandra C. Brown, Emma De Jong, Bernadette Jones-Freeman, Md Khadem Ali, Henry M. Gomez, Kurtis F. Budden, Malcolm R. Starkey, Guy J.M. Cameron, Svenja Loering, Duc H. Nguyen, Prema Mono Nair, Tatt Jhong Haw, Charlotte A. Alemao, Alen Faiz, Hock L. Tay, Peter A.B. Wark, Chantal Donovan
Background Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COPD overlap (ACO). Patients characterized with ACO have increased disease severity, however the mechanisms driving this have not been widely studied. Objective To characterize the phenotypic and transcriptomic features of experimental
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Seasonal-specific Variations of the Upper Airway Microbiome and Childhood Asthma: Friend or Foe? J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-25 Joseph A. Bellanti
Abstract not available
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Current vaccine strategies against SARS-CoV-2 - Promises and Challenges J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-23 Drishya Kurup, Jacob Myers, Matthias J. Schnell
In the years since the SARS-CoV-2 pandemic began and spread across the globe, lessons have been learned about the challenges and opportunities a pandemic brings to humankind. Researchers have produced many vaccines at unprecedented speed to protect people but have also been cognizant of the challenges presented by a new and unexpected infectious disease. The scope of this review is to examine the path
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What can we learn from treating atopic itch in dogs? J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-21 Angelina Labib, Gil Yosipovitch, Thierry Olivry
Abstract not available
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A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-20 Evan S. Dellon, Paneez Khoury, Amanda B. Muir, Chris A. Liacouras, Ekaterina Safroneeva, Dan Atkins, Margaret H. Collins, Nirmala Gonsalves, Gary W. Falk, Jonathan M. Spergel, Ikuo Hirano, Mirna Chehade, Alain M. Schoepfer, Calies Menard-Katcher, David A. Katzka, Peter A. Bonis, Albert J. Bredenoord, Bob Geng, Seema S. Aceves
Background & Aims Disease activity and severity of eosinophilic esophagitis (EoE) dictate therapeutic options and management, but the decision-making process for determining severity varies among practitioners. To reduce variability in practice patterns and help clinicians monitor the clinical course of the disease in an office setting, we aimed to create an international consensus severity scoring
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Socioeconomic status associates with worse asthma morbidity among Black and Latinx adults J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-18 Juan Carlos Cardet, Ku-Lang Chang, Benjamin J. Rooks, Jennifer K. Carroll, Juan Carlos Celedón, Tamera Coyne-Beasley, Jing Cui, Brianna Ericson, Victoria E. Forth, Maureen Fagan, Anne L. Fuhlbrigge, Paulina Arias Hernandez, Jean Kruse, Margee Louisias, Nancy E. Maher, Brian Manning, Wilson D. Pace, Wanda Phipatanakul, Juan P. Wisnivesky
Background Asthma disproportionately affects African-American/Black (AA/B) and Hispanic/Latinx (H/L) patients and individuals with low socioeconomic status (SES), but the relationship between SES and asthma morbidity within these racial/ethnic groups is inadequately understood. Objective To determine the relationship between SES and asthma morbidity among AA/B and H/L adults with moderate-severe asthma
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The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-18 Rachel L. Peters, Imma Guarnieri, Mimi L.K. Tang, Adrian J. Lowe, Shyamali C. Dharmage, Kirsten P. Perrett, Lyle C. Gurrin, Jennifer J. Koplin
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Multiancestral polygenic risk score for pediatric asthma J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-18 Bahram Namjou, Michael Lape, Edyta Malolepsza, Stanley B. DeVore, Matthew T. Weirauch, Ozan Dikilitas, Gail P. Jarvik, Krzysztof Kiryluk, Iftikhar J. Kullo, Cong Liu, Yuan Luo, Benjamin A. Satterfield, Jordan W. Smoller, Theresa L. Walunas, John Connolly, Patrick Sleiman, Tesfaye B. Mersha, Frank D. Mentch, Leah Kottyan
Background Asthma is the most common chronic condition in children and the third leading cause of hospitalization in pediatrics. The genome-wide association study catalog reports 140 studies with genome wide significance. A polygenic risk score (PRS) with predictive value across ancestries has not been evaluated for this important trait. Objective We aim to train and validate a PRS relying on genetic
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T follicular helper cells mediate local production of allergen-specific IgE and IgG4 J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-16 Mitsuhiro Akiyama, Yuko Kaneko, Tsutomu Takeuchi
Abstract not available
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Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-16 Akimasa Adachi, Tetsuya Honda, Gyohei Egawa, Shuto Kanameishi, Riko Takimoto, Toshiya Miyake, Md Razib Hossain, Mayumi Komine, Mamitaro Ohtsuki, Matthias Gunzer, Koichi Ikuta, Kenji Kabashima
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Applying Dissemination and Implementation Research Methods to Translate a School-Based Asthma Program J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-13 Stanley J. Szefler, Lisa Cicutto, Sarah E. Brewer, Melanie Gleason, Arthur McFarlane, Lisa Ross DeCamp, John T. Brinton, Amy G. Huebschmann
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The unfulfilled potential of mucosal immunization J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-13 James R. Baker, Mohammad Farazuddin, Pamela T. Wong, Jessica J. O’Konek
Recent events involving the global coronavirus pandemic have focused attention on vaccination strategies. While tremendous advances have been made in subcutaneous and intramuscular vaccines during this time, one area that has lagged in implementation is mucosal immunization. Mucosal immunization provides several potential advantages over subcutaneous and intramuscular routes, including protection from
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SARS-CoV-2 vaccination in the immunocompromised host J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-12 Caoilfhionn M. Connolly, Julie J. Paik
Abstract not available
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Reply J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-12 Laura R. Hoyt, Adam Williams, Stephanie C. Eisenbarth
Abstract not available
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Is allergen absorption a key determinant of severity in food-induced reactions? J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-12 Paul J. Turner
Abstract not available
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Single-cell analysis implicates Th17 to Th2 cell plasticity in the pathogenesis of palmoplantar pustulosis J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-12 Daniel McCluskey, Natashia Benzian-Olsson, Satveer K. Mahil, Nina Karoliina Hassi, Christian T. Wohnhaas, A David Burden, Christopher EM. Griffiths, John R. Ingram, Nick J. Levell, Richard Parslew, Andrew E. Pink, Nick J. Reynolds
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Distinct disease-specific Tfh cell populations in two different fibrotic diseases: IgG4-related disease and Kimura’s disease J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-11 Ryusuke Munemura, Takashi Maehara, Yuka Murakami, Risako Koga, Ryuichi Aoyagi, Naoki Kaneko, Atsushi Doi, Cory A. Perugino, Emanuel Della-Torre, Takako Saeki, Yasuharu Sato, Hidetaka Yamamoto, Tamotsu Kiyoshima, John H. Stone, Shiv Pillai, Seiji Nakamura
Background How T follicular (Tfh) cells contribute to many different B-cell class-switching events during T cell-dependent immune responses has been unclear. Diseases with polarized isotype switching offer a unique opportunity for the exploration of Tfh subsets. Secondary and tertiary lymphoid organs (SLOs and TLOs) in patients with elevated tissue expression levels of IgE (Kimura’s disease, KD) and
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Dynamin Related Protein 1 Differentially Regulates FcεRI- and SP-induced Mast Cell Activation J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-11 Ying Wang, Mang Yu, Kazufumi Matsushita, Chen Liu, Naotada Ishihara, Masatoshi Nomura, Mindy Tsai, Stephen J. Galli
Background The mitochondrial fission protein, dynamin related protein 1 (Drp1), has been suggested to regulate mast cell (MC) activation by certain stimuli in vitro but its functions in MCs activated by various stimuli in vivo has not been examined. Objective Analyze Drp1 function in both mouse and human MCs. Methods We used human peripheral blood-derived cultured MCs (PBCMCs) and two genetic mouse
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Multi-scale study of the oral and gut environments in children with high and low threshold peanut allergy J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-10 Lingdi Zhang, Yoojin Chun, Hsi-en Ho, Zoe Arditi, Tracy Lo, Swathy Sajja, Rebecca Rose, Drew Jones, Julie Wang, Scott Sicherer, Supinda Bunyavanich
Background The oral and gut microbiomes have each been associated with food allergy status. Within food allergy, they may also influence reaction thresholds. Objective To identify oral and gut microbiota associated with reaction thresholds in peanut allergy. Methods 59 children ages 4 to 14 years with suspected peanut allergy underwent double-blind, placebo-controlled food challenge to peanut. Children
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Differential mast cell mediators in Systemic Mastocytosis and Hereditary Alpha-tryptasemia J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-09 Matthew P. Giannetti, Grace Godwin, Emily Weller, Joseph H. Butterfield, Mariana Castells
Background Patients with systemic mastocytosis often have symptoms of mast cell activation which is associated with elevated levels of urinary mast cell mediator metabolites. Patients with hereditary alpha-tryptasemia (HαT) may present with symptoms of mast cell activation. It is not known whether levels of mast cell mediators are elevated in this patient population. Objective The purpose of this study
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FeNO differentiates epithelial gene expression clusters: exploratory analysis from the MESOS randomised controlled trial J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-07 Sarah Diver, Sriram Sridhar, Latifa C. Khalfaoui, Richard J. Russell, Claire Emson, Janet M. Griffiths, Melissa de los Reyes, Da Yin, Gene Colice, Christopher E. Brightling
Background Understanding how asthma biomarkers relate to gene expression signatures could help identify drivers of pathogenesis. Objective This post hoc exploratory analysis of the phase II tralokinumab trial, MESOS (NCT02449473), aimed to profile baseline airway inflammation in patients with moderate-to-severe asthma. Methods The T2 and T17 gene expression signatures, 3- and 5- gene mean (3- and 5GM)
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Brief Overview of This Month's JACI J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-04
Abstract not available
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Table of Contents J. Allergy Clin. Immunol. (IF 10.793) Pub Date : 2022-05-04
Abstract not available