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Engram mechanisms of memory linking and identity Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-04-25 Ali Choucry, Masanori Nomoto, Kaoru Inokuchi
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A guide to science communication training for doctoral students Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-26 Christina Maher, Trevonn Gyles, Eric J. Nestler, Daniela Schiller
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Spatiotemporal Dynamics of Successive Activations across the Human Brain during Simple Arithmetic Processing J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Pedro Pinheiro-Chagas, Clara Sava-Segal, Serdar Akkol, Amy Daitch, Josef Parvizi
Previous neuroimaging studies have offered unique insights about the spatial organization of activations and deactivations across the brain; however, these were not powered to explore the exact timing of events at the subsecond scale combined with a precise anatomical source of information at the level of individual brains. As a result, we know little about the order of engagement across different
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Ndnf Interneuron Excitability Is Spared in a Mouse Model of Dravet Syndrome J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Sophie R. Liebergall, Ethan M. Goldberg
Dravet syndrome (DS) is a neurodevelopmental disorder characterized by epilepsy, developmental delay/intellectual disability, and features of autism spectrum disorder, caused by heterozygous loss-of-function variants in SCN1A encoding the voltage-gated sodium channel α subunit Nav1.1. The dominant model of DS pathogenesis is the "interneuron hypothesis," whereby GABAergic interneurons (INs) express
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Encoding of Predictive Associations in Human Prefrontal and Medial Temporal Neurons During Pavlovian Appetitive Conditioning J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Tomas G. Aquino, Hristos Courellis, Adam N. Mamelak, Ueli Rutishauser, John P. O′Doherty
Pavlovian conditioning is thought to involve the formation of learned associations between stimuli and values, and between stimuli and specific features of outcomes. Here, we leveraged human single neuron recordings in ventromedial prefrontal, dorsomedial frontal, hippocampus, and amygdala while patients of both sexes performed an appetitive Pavlovian conditioning task probing both stimulus–value and
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Integration of Prior Expectations and Suppression of Prediction Errors During Expectancy-Induced Pain Modulation: The Influence of Anxiety and Pleasantness J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Hsin-Yun Tsai, Kulvara Lapanan, Yi-Hsuan Lin, Cheng-Wei Huang, Wen-Wei Lin, Min-Min Lin, Zheng-Liang Lu, Feng-Sheng Lin, Ming-Tsung Tseng
Pain perception arises from the integration of prior expectations with sensory information. Although recent work has demonstrated that treatment expectancy effects (e.g., placebo hypoalgesia) can be explained by a Bayesian integration framework incorporating the precision level of expectations and sensory inputs, the key factor modulating this integration in stimulus expectancy-induced pain modulation
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Acetylcholine Engages Distinct Amygdala Microcircuits to Gate Internal Theta Rhythm J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Joshua X. Bratsch-Prince, James W. Warren, Grace C. Jones, Alexander J. McDonald, David D. Mott
Acetylcholine (ACh) is released from basal forebrain cholinergic neurons in response to salient stimuli and engages brain states supporting attention and memory. These high ACh states are associated with theta oscillations, which synchronize neuronal ensembles. Theta oscillations in the basolateral amygdala (BLA) in both humans and rodents have been shown to underlie emotional memory, yet their mechanism
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Re-examining the Mysterious Role of the Cerebellum in Pain J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Crystal N. Li, Kevin A. Keay, Luke A. Henderson, Richelle Mychasiuk
Pain is considered a multidimensional experience that embodies not merely sensation, but also emotion and perception. As is appropriate for this complexity, pain is represented and processed by an extensive matrix of cortical and subcortical structures. Of these structures, the cerebellum is gaining increasing attention. Although association between the cerebellum and both acute and chronic pain have
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Serotonin Signaling in Hippocampus during Initial Cocaine Abstinence Drives Persistent Drug Seeking J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Amy S. Kohtz, Joshua Zhao, Gary Aston-Jones
The initiation of abstinence after chronic drug self-administration is stressful. Cocaine-seeking behavior on the first day of the absence of the expected drug (Extinction Day 1, ED1) is reduced by blocking 5-HT signaling in dorsal hippocampal cornu ammonis 1 (CA1) in both male and female rats. We hypothesized that the experience of ED1 can substantially influence later relapse behavior and that dorsal
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Hypothalamic Paraventricular Stimulation Inhibits Nociceptive Wide Dynamic Range Trigeminocervical Complex Cells via Oxytocinergic Transmission J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Miguel Condés-Lara, Guadalupe Martínez-Lorenzana, Antonio Espinosa de los Monteros-Zúñiga, Gustavo López-Córdoba, Aketzalli Córdova-Quiroga, Shakty A. Flores-Bojórquez, Abimael González-Hernández
Oxytocinergic transmission blocks nociception at the peripheral, spinal, and supraspinal levels through the oxytocin receptor (OTR). Indeed, a neuronal pathway from the hypothalamic paraventricular nucleus (PVN) to the spinal cord and trigeminal nucleus caudalis (Sp5c) has been described. Hence, although the trigeminocervical complex (TCC), an anatomical area spanning the Sp5c, C1, and C2 regions,
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Coupling of Sharp Wave Events between Zebrafish Hippocampal and Amygdala Homologs J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Ismary Blanco, Adam Caccavano, Jian-Young Wu, Stefano Vicini, Eric Glasgow, Katherine Conant
The mammalian hippocampus exhibits spontaneous sharp wave events (1–30 Hz) with an often-present superimposed fast ripple oscillation (120–220 Hz) to form a sharp wave ripple (SWR) complex. During slow-wave sleep or quiet restfulness, SWRs result from the sequential spiking of hippocampal cell assemblies initially activated during learned or imagined experiences. Additional cortical/subcortical areas
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The Neurobiology of Life Course Socioeconomic Conditions and Associated Cognitive Performance in Middle to Late Adulthood J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Stephanie Schrempft, Olga Trofimova, Morgane Künzi, Cristina Ramponi, Antoine Lutti, Ferath Kherif, Adeliya Latypova, Peter Vollenweider, Pedro Marques-Vidal, Martin Preisig, Matthias Kliegel, Silvia Stringhini, Bogdan Draganski
Despite major advances, our understanding of the neurobiology of life course socioeconomic conditions is still scarce. This study aimed to provide insight into the pathways linking socioeconomic exposures—household income, last known occupational position, and life course socioeconomic trajectories—with brain microstructure and cognitive performance in middle to late adulthood. We assessed socioeconomic
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PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the Vestibulo-ocular Reflex during Juvenile Development J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Bin Wu, Laura Post, Zhanmin Lin, Martijn Schonewille
Throughout life, the cerebellum plays a central role in the coordination and optimization of movements, using cellular plasticity to adapt a range of behaviors. Whether these plasticity processes establish a fixed setpoint during development, or continuously adjust behaviors throughout life, is currently unclear. Here, by spatiotemporally manipulating the activity of protein phosphatase 2B (PP2B),
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Value Estimation versus Effort Mobilization: A General Dissociation between Ventromedial and Dorsomedial Prefrontal Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Nicolas Clairis, Mathias Pessiglione
Deciding on a course of action requires both an accurate estimation of option values and the right amount of effort invested in deliberation to reach sufficient confidence in the final choice. In a previous study, we have provided evidence, across a series of judgment and choice tasks, for a dissociation between the ventromedial prefrontal cortex (vmPFC), which would represent option values, and the
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Neuronal Modeling of Cross-Sensory Visual Evoked Magnetoencephalography Responses in the Auditory Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Kaisu Lankinen, Jyrki Ahveninen, Mainak Jas, Tommi Raij, Seppo P. Ahlfors
Previous studies have demonstrated that auditory cortex activity can be influenced by cross-sensory visual inputs. Intracortical laminar recordings in nonhuman primates have suggested a feedforward (FF) type profile for auditory evoked but feedback (FB) type for visual evoked activity in the auditory cortex. To test whether cross-sensory visual evoked activity in the auditory cortex is associated with
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PTPN11/Corkscrew Activates Local Presynaptic Mapk Signaling to Regulate Synapsin, Synaptic Vesicle Pools, and Neurotransmission Strength, with a Dual Requirement in Neurons and Glia J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Shannon N. Leahy, Dominic J. Vita, Kendal Broadie
Cytoplasmic protein tyrosine phosphatase nonreceptor type 11 (PTPN11) and Drosophila homolog Corkscrew (Csw) regulate the mitogen-activated protein kinase (MAPK) pathway via a conserved autoinhibitory mechanism. Disease-causing loss-of-function (LoF) and gain-of-function (GoF) mutations both disrupt this autoinhibition to potentiate MAPK signaling. At the Drosophila neuromuscular junction glutamatergic
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A Unifying Model for Discordant and Concordant Results in Human Neuroimaging Studies of Facial Viewpoint Selectivity J. Neurosci. (IF 5.3) Pub Date : 2024-04-24 Cambria Revsine, Javier Gonzalez-Castillo, Elisha P. Merriam, Peter A. Bandettini, Fernando M. Ramírez
Recognizing faces regardless of their viewpoint is critical for social interactions. Traditional theories hold that view-selective early visual representations gradually become tolerant to viewpoint changes along the ventral visual hierarchy. Newer theories, based on single-neuron monkey electrophysiological recordings, suggest a three-stage architecture including an intermediate face-selective patch
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Skill switching Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-04-25 Sian Lewis
The main direction of motor skill-specific information between rat primary motor cortex and dorsolateral striatum is shown to switch from cortex-predominant before learning to striatum-predominant after learning.
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The molecular determinants of microglial developmental dynamics Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-04-24 Liam Barry-Carroll, Diego Gomez-Nicola
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Unleashing the potential of mRNA therapeutics for inherited neurological diseases Brain (IF 14.5) Pub Date : 2024-04-25 Edoardo Monfrini, Giacomo Baso, Dario Ronchi, Megi Meneri, Delia Gagliardi, Lorenzo Quetti, Federico Verde, Nicola Ticozzi, Antonia Ratti, Alessio Di Fonzo, Giacomo P Comi, Linda Ottoboni, Stefania Corti
Neurological monogenic loss-of-function diseases are hereditary disorders resulting from gene mutations that decrease or abolish the normal function of the encoded protein. These conditions pose significant therapeutic challenges, which may be resolved through the development of innovative therapeutic strategies. RNA-based technologies, such as mRNA replacement therapy, have emerged as promising and
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Revisiting distinct nerve excitability patterns in patients with amyotrophic lateral sclerosis Brain (IF 14.5) Pub Date : 2024-04-25 Diederik J L Stikvoort García, H Stephan Goedee, Ruben P A van Eijk, Leonard J van Schelven, Leonard H van den Berg, Boudewijn T H M Sleutjes
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease, characterized by loss of central and peripheral motor neurones. Although the disease is clinically and genetically heterogeneous, axonal hyperexcitability is a commonly observed feature that has been suggested to reflect an early pathophysiological step linked to the neurodegenerative cascade. Therefore, it is important to clarify
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Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo Brain (IF 14.5) Pub Date : 2024-04-25 Manoj Upadhya, Toni Kirmann, Max A Wilson, Christian M Simon, Divya Dhangar, Christian Geis, Robyn Williams, Gavin Woodhall, Stefan Hallermann, Sarosh R Irani, Sukhvir K Wright
One striking clinical hallmark in patients with autoantibodies to leucine-rich glioma inactivated 1 (LGI1) is the very frequent focal seizure semiologies, including faciobrachial dystonic seizures (FBDS), in addition to the amnesia. Polyclonal serum IgGs have successfully modelled the cognitive changes in vivo but not seizures. Hence, it remains unclear whether LGI1-autoantibodies are sufficient to
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A new type of blood–brain barrier aminoacidopathy underlies metabolic microcephaly associated with SLC1A4 mutations Brain (IF 14.5) Pub Date : 2024-04-25 Maali Odeh, Clara Sajrawi, Adam Majcher, Salman Zubedat, Lihi Shaulov, Alex Radzishevsky, Liron Mizrahi, Wendy K Chung, Avi Avital, Thorsten Hornemann, Daniel J Liebl, Inna Radzishevsky, Herman Wolosker
Mutations in the SLC1A4 transporter lead to neurodevelopmental impairments, spastic tetraplegia, thin corpus callosum, and microcephaly in children. SLC1A4 catalyzes obligatory amino acid exchange between neutral amino acids, but the physiopathology of SLC1A4 disease mutations and progressive microcephaly remain unclear. Here, we examined the phenotype and metabolic profile of three Slc1a4 mouse models
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Three patterns link brain organization to genes in health and disease Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-24
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Morbidity and mortality risks associated with valproate withdrawal in young men and women with epilepsy Brain (IF 14.5) Pub Date : 2024-04-24 Gashirai K Mbizvo, Tommaso Bucci, Gregory Y H Lip, Anthony G Marson
Valproate is the most effective treatment for idiopathic generalised epilepsy. Current guidance precludes its use in women of childbearing potential, unless other treatments are ineffective or not tolerated, because of high teratogenicity. This risk was recently extended to men. New guidance will limit use both in men and women aged <55 years, resulting in withdrawal of valproate from men already taking
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A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings Brain (IF 14.5) Pub Date : 2024-04-24 Hannah Baumeister, Jacob W Vogel, Philip S Insel, Luca Kleineidam, Steffen Wolfsgruber, Melina Stark, Helena M Gellersen, Renat Yakupov, Matthias C Schmid, Falk Lüsebrink, Frederic Brosseron, Gabriel Ziegler, Silka D Freiesleben, Lukas Preis, Luisa-Sophie Schneider, Eike J Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Ina R Vogt, Claudia Bartels, Björn H Schott, Ayda Rostamzadeh, Wenzel
Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer’s disease (AD) patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference
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Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer’s disease and 5XFAD mice Brain (IF 14.5) Pub Date : 2024-04-23 Aaron J Barbour, Sarah Gourmaud, Eunjoo Lancaster, Xiaofan Li, David A Stewart, Keegan F Hoag, David J Irwin, Delia M Talos, Frances E Jensen
Approximately 22% of Alzheimer’s disease (AD) patients suffer from seizures, and the co-occurrence of seizures and epileptiform activity exacerbates AD pathology and related cognitive deficits, suggesting that seizures may be a targetable component of AD progression. Given that alterations in neuronal excitatory:inhibitory (E:I) balance occur in epilepsy, we hypothesized that decreased markers of inhibition
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Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders Brain (IF 14.5) Pub Date : 2024-04-23 Anne T Berg, Christopher H Thompson, Leah Schust Myers, Erica Anderson, Lindsey Evans, Ariela J E Kaiser, Katherine Paltell, Amanda N Nili, Jean-Marc DeKeyser, Tatiana V Abramova, Gerry Nesbitt, Shawn Egan, Carlos G Vanoye, Alfred L George
SCN2A-related disorders secondary to altered function in the voltage-gated sodium channel NaV1.2 are rare with clinically heterogeneous expressions that include epilepsy, autism, and multiple severe to profound impairments and other conditions. To advance understanding of the clinical phenotypes and their relation to channel function, 81 patients (36, 44% female, median age 5.4 years) with 69 unique
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Leptin receptor reactivation restores brain function in early-life Lepr-deficient mice Brain (IF 14.5) Pub Date : 2024-04-23 Caroline Fernandes, Leticia Forny-Germano, Mayara M Andrade, Natalia M Lyra E Silva, Angela M Ramos-Lobo, Fernanda Meireles, Fernanda Tovar-Moll, Jean Christophe Houzel, Jose Donato, Fernanda G De Felice
Obesity is a chronic disease caused by excessive fat accumulation that impacts the body and brain health. Insufficient leptin or leptin receptor (LepR) are involved in the disease pathogenesis. Leptin is involved with several neurological processes, and it has critical developmental roles. We have previously demonstrated that leptin deficiency in early life leads to permanent developmental problems
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Thalamic epileptic spikes disrupt sleep spindles in patients with epileptic encephalopathy Brain (IF 14.5) Pub Date : 2024-04-23 Anirudh Wodeyar, Dhinakaran Chinappen, Dimitris Mylonas, Bryan Baxter, Dara S Manoach, Uri T Eden, Mark A Kramer, Catherine J Chu
In severe epileptic encephalopathies, epileptic activity contributes to progressive cognitive dysfunction. Epileptic encephalopathies share the trait of spike-wave activation during non-rapid eye movement sleep (EE-SWAS), a sleep stage dominated by sleep spindles, brain oscillations known to coordinate offline memory consolidation. Epileptic activity has been proposed to hijack the circuits driving
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Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-22 Richard Dear, Konrad Wagstyl, Jakob Seidlitz, Ross D. Markello, Aurina Arnatkevičiūtė, Kevin M. Anderson, Richard A. I. Bethlehem, Armin Raznahan, Edward T. Bullmore, Petra E. Vértes
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Multivariate mapping of low-resilient neurocognitive systems within and around low-grade gliomas Brain (IF 14.5) Pub Date : 2024-04-22 Sam Ng, Sylvie Moritz-Gasser, Anne-Laure Lemaitre, Hugues Duffau, Guillaume Herbet
Accumulating evidence suggests that the brain exhibits a remarkable capacity for functional compensation in response to neurological damage, a resilience potential that is deeply rooted in the malleable features of its underlying anatomo-functional architecture. This propensity is particularly exemplified by diffuse low-grade gliomas (DLGGs), a subtype of primary brain tumour. However, functional plasticity
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Spatial enrichment and genomic analyses reveal the link of NOMO1 with amyotrophic lateral sclerosis Brain (IF 14.5) Pub Date : 2024-04-21 Jingyan Guo, Linya You, Yu Zhou, Jiali Hu, Jiahao Li, Wanli Yang, Xuelin Tang, Yimin Sun, Yuqi Gu, Yi Dong, Xi Chen, Christine Sato, Lorne Zinman, Ekaterina Rogaeva, Jian Wang, Yan Chen, Ming Zhang
Amyotrophic lateral sclerosis (ALS) is a severe motor neuron disease with uncertain genetic predisposition in most sporadic cases. Spatial architecture of cell types and gene expression is the basis of cell-cell interactions, biological function and disease pathology, but is not well investigated in human motor cortex, a key ALS relevant brain region. Recent studies indicated single nucleus transcriptomic
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Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline? Brain (IF 14.5) Pub Date : 2024-04-21 Maria H Eriksson, Freya Prentice, Rory J Piper, Konrad Wagstyl, Sophie Adler, Aswin Chari, John Booth, Friederike Moeller, Krishna Das, Christin Eltze, Gerald Cooray, Ana Perez Caballero, Lara Menzies, Amy McTague, Sara Shavel-Jessop, Martin M Tisdall, J Helen Cross, Patricia Martin Sanfilippo, Torsten Baldeweg
Neuropsychological impairments are common in children with drug-resistant epilepsy. It has been proposed that epilepsy surgery may alleviate these impairments by providing seizure freedom; however, findings from prior studies have been inconsistent. We mapped long-term neuropsychological trajectories in children before and after undergoing epilepsy surgery, to measure the impact of disease course and
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Encoding of Visual Objects in the Human Medial Temporal Lobe J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Yue Wang, Runnan Cao, Shuo Wang
The human medial temporal lobe (MTL) plays a crucial role in recognizing visual objects, a key cognitive function that relies on the formation of semantic representations. Nonetheless, it remains unknown how visual information of general objects is translated into semantic representations in the MTL. Furthermore, the debate about whether the human MTL is involved in perception has endured for a long
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Neuronal Ensembles in the Amygdala Allow Social Information to Motivate Later Decisions J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Henry W. Kietzman, Gracy Trinoskey-Rice, Esther H. Seo, Jidong Guo, Shannon L. Gourley
Social experiences carry tremendous weight in our decision-making, even when social partners are not present. To determine mechanisms, we trained female mice to respond for two food reinforcers. Then, one food was paired with a novel conspecific. Mice later favored the conspecific-associated food, even in the absence of the conspecific. Chemogenetically silencing projections from the prelimbic subregion
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Monosynaptic Rabies Tracing Reveals Sex- and Age-Dependent Dorsal Subiculum Connectivity Alterations in an Alzheimer's Disease Mouse Model J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Qiao Ye, Gocylen Gast, Erik George Wilfley, Hanh Huynh, Chelsea Hays, Todd C. Holmes, Xiangmin Xu
The subiculum (SUB), a hippocampal formation structure, is among the earliest brain regions impacted in Alzheimer's disease (AD). Toward a better understanding of AD circuit-based mechanisms, we mapped synaptic circuit inputs to dorsal SUB using monosynaptic rabies tracing in the 5xFAD mouse model by quantitatively comparing the circuit connectivity of SUB excitatory neurons in age-matched controls
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Human Motor Neurons Elicit Pathological Hallmarks of ALS and Reveal Potential Biomarkers of the Disease in Response to Prolonged IFN{gamma} Exposure J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Changho Chun, Jung Hyun Lee, Mark Bothwell, Paul Nghiem, Alec S. T. Smith, David L. Mack
Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder marked by progressive motor neuron degeneration and muscle denervation. A recent transcriptomic study integrating a wide range of human ALS samples revealed that the upregulation of p53, a downstream target of inflammatory stress, is commonly detected in familial and sporadic ALS cases by a mechanism linked to a transactive
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Defining Overlooked Structures Reveals New Associations between the Cortex and Cognition in Aging and Alzheimer's Disease J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Samira A. Maboudian, Ethan H. Willbrand, Joseph P. Kelly, William J. Jagust, Kevin S. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative
Recent work suggests that indentations of the cerebral cortex, or sulci, may be uniquely vulnerable to atrophy in aging and Alzheimer's disease (AD) and that the posteromedial cortex (PMC) is particularly vulnerable to atrophy and pathology accumulation. However, these studies did not consider small, shallow, and variable tertiary sulci that are located in association cortices and are often associated
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Recurrent Neural Circuits Overcome Partial Inactivation by Compensation and Re-learning J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Colin Bredenberg, Cristina Savin, Roozbeh Kiani
Technical advances in artificial manipulation of neural activity have precipitated a surge in studying the causal contribution of brain circuits to cognition and behavior. However, complexities of neural circuits challenge interpretation of experimental results, necessitating new theoretical frameworks for reasoning about causal effects. Here, we take a step in this direction, through the lens of recurrent
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Single-Cell Analysis of Rohon-Beard Neurons Implicates Fgf Signaling in Axon Maintenance and Cell Survival J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Adam M. Tuttle, Lauren N. Miller, Lindsey J. Royer, Hua Wen, Jimmy J. Kelly, Nicholas L. Calistri, Laura M. Heiser, Alex V. Nechiporuk
Peripheral sensory neurons are a critical part of the nervous system that transmit a multitude of sensory stimuli to the central nervous system. During larval and juvenile stages in zebrafish, this function is mediated by Rohon–Beard somatosensory neurons (RBs). RBs are optically accessible and amenable to experimental manipulation, making them a powerful system for mechanistic investigation of sensory
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Linear and Nonlinear Behaviors of the Photoreceptor Coupled Network J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Ji-Jie Pang, Xiaolong Jiang, Samuel M. Wu
Photoreceptors are electrically coupled to one another, and the spatiotemporal properties of electrical synapses in a two-dimensional retinal network are still not well studied, because of the limitation of the single electrode or pair recording techniques which do not allow simultaneously measuring responses of multiple photoreceptors at various locations in the retina. A multiple electrode recording
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Assessing Spontaneous Categorical Processing of Visual Shapes via Frequency-Tagging EEG J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Jaana Van Overwalle, Stephanie Van der Donck, Sander Van de Cruys, Bart Boets, Johan Wagemans
Categorization is an essential cognitive and perceptual process, which happens spontaneously. However, earlier research often neglected the spontaneous nature of this process by mainly adopting explicit tasks in behavioral or neuroimaging paradigms. Here, we use frequency-tagging (FT) during electroencephalography (EEG) in 22 healthy human participants (both male and female) as a direct approach to
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Converging Effects of Chronic Pain and Binge Alcohol Consumption on Anterior Insular Cortex Neurons Projecting to the Dorsolateral Striatum in Male Mice J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Yuexi Yin, David L. Haggerty, Shudi Zhou, Brady K. Atwood, Patrick L. Sheets
Chronic pain and alcohol use disorder (AUD) are highly comorbid, and patients with chronic pain are more likely to meet the criteria for AUD. Evidence suggests that both conditions alter similar brain pathways, yet this relationship remains poorly understood. Prior work shows that the anterior insular cortex (AIC) is involved in both chronic pain and AUD. However, circuit-specific changes elicited
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Age-Related Deficits in Binaural Hearing: Contribution of Peripheral and Central Effects J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Sandra Tolnai, Mariella Weiß, Rainer Beutelmann, Jens P. Bankstahl, Sonny Bovee, Tobias L. Ross, Georg Berding, Georg M. Klump
Pure-tone audiograms often poorly predict elderly humans’ ability to communicate in everyday complex acoustic scenes. Binaural processing is crucial for discriminating sound sources in such complex acoustic scenes. The compromised perception of communication signals presented above hearing threshold has been linked to both peripheral and central age-related changes in the auditory system. Investigating
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Upregulated GIRK2 Counteracts Ethanol-Induced Changes in Excitability and Respiration in Human Neurons J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Iya Prytkova, Yiyuan Liu, Michael Fernando, Isabel Gameiro-Ros, Dina Popova, Chella Kamarajan, Xiaoling Xuei, David B. Chorlian, Howard J. Edenberg, Jay A. Tischfield, Bernice Porjesz, Zhiping P. Pang, Ronald P. Hart, Alison Goate, Paul A. Slesinger
Genome-wide association studies (GWAS) of electroencephalographic endophenotypes for alcohol use disorder (AUD) has identified noncoding polymorphisms within the KCNJ6 gene. KCNJ6 encodes GIRK2, a subunit of a G-protein-coupled inwardly rectifying potassium channel that regulates neuronal excitability. We studied the effect of upregulating KCNJ6 using an isogenic approach with human glutamatergic neurons
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Intracerebral Dynamics of Sleep Arousals: A Combined Scalp-Intracranial EEG Study J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Yingqi Laetitia Wang, Tamir Avigdor, Sana Hannan, Chifaou Abdallah, François Dubeau, Laure Peter-Derex, Birgit Frauscher
As an intrinsic component of sleep architecture, sleep arousals represent an intermediate state between sleep and wakefulness and are important for sleep–wake regulation. They are defined in an all-or-none manner, whereas they actually present a wide range of scalp-electroencephalography (EEG) activity patterns. It is poorly understood how these arousals differ in their mechanisms. Stereo-EEG (SEEG)
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Mnemonic But Not Contextual Feedback Signals Defy Dedifferentiation in the Aging Early Visual Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-04-17 Isabelle Ehrlich, Javier Ortiz-Tudela, Yi You Tan, Lars Muckli, Yee Lee Shing
Perception is an intricate interplay between feedforward visual input and internally generated feedback signals that comprise concurrent contextual and time-distant mnemonic (episodic and semantic) information. Yet, an unresolved question is how the composition of feedback signals changes across the lifespan and to what extent feedback signals undergo age-related dedifferentiation, that is, a decline
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In conversation with Fernando de Castro Soubriet Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-18 Elisa Floriddia
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Fernando de Castro Soubriet, principal investigator at the Instituto Cajal (Spain). He is a neurodevelopmental biologist who is actively involved in
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Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain Nat. Neurosci. (IF 25.0) Pub Date : 2024-04-18 Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwartz
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Increased frequency and mortality in persons with neurological disorders during COVID-19 Brain (IF 14.5) Pub Date : 2024-04-18 Candace M Marsters, Jeffrey A Bakal, Grace Y Lam, Finlay A McAlister, Christopher Power
Determining the frequency and outcomes of neurological disorders associated with COVID-19 is imperative for understanding risks as well as recognition of emerging neurological disorders. We investigated the susceptibility and impact of SARS-CoV-2 infection among persons with premorbid neurological disorder rs, as well as the post-infection incidence of neurological sequelae in a case-control population-based
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Different learning aberrations relate to delusion-like beliefs with different contents Brain (IF 14.5) Pub Date : 2024-04-18 Rosa Rossi-Goldthorpe, Steven M Silverstein, James M Gold, Jason Schiffman, James A Waltz, Trevor F Williams, Albert R Powers, Scott W Woods, Richard E Zinbarg, Vijay A Mittal, Lauren M Ellman, Gregory P Strauss, Elaine F Walker, Jason A Levin, Santiago Castiello, Joshua Kenney, Philip R Corlett
The prediction error account of delusions has had success. However, its explanation of delusions with different contents has been lacking. Persecutory delusions and paranoia are the common unfounded beliefs that others have harmful intentions towards us. Other delusions include believing that one’s thoughts or actions are under external control, or that events in the world have specific personal meaning
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Genetics of immune response to Epstein-Barr virus: prospects for multiple sclerosis pathogenesis Brain (IF 14.5) Pub Date : 2024-04-17 Jesse Huang, Katarina Tengvall, Izaura Bomfim Lima, Anna Karin Hedström, Julia Butt, Nicole Brenner, Alexandra Gyllenberg, Pernilla Stridh, Mohsen Khademi, Ingemar Ernberg, Faiez Al Nimer, Ali Manouchehrinia, Jan Hillert, Lars Alfredsson, Oluf Andersen, Peter Sundström, Tim Waterboer, Tomas Olsson, Ingrid Kockum
Epstein-Barr virus (EBV) infection has been advocated as a prerequisite for developing multiple sclerosis (MS) and possibly the propagation of the disease. However, the precise mechanisms for such influences are still unclear. A large-scale study investigating the host genetics of EBV serology and related clinical manifestations, such as infectious mononucleosis (IM), may help us better understand
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Attentional capture Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-04-15 Isobel Leake
A large network of brain regions is involved in salient distractor processing.
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Subtitled speech: the neural mechanisms of ticker-tape synaesthesia Brain (IF 14.5) Pub Date : 2024-04-15 Fabien Hauw, Benoît Béranger, Laurent Cohen
Reading acquisition modifies areas of the brain associated with vision, with language, and their connections. Those changes enable reciprocal translation between orthography, and word sounds and meaning. Individual variability in the pre-existing cerebral substrate contributes to the range of eventual reading abilities, extending to atypical developmental patterns, including dyslexia and reading-related
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The language network as a natural kind within the broader landscape of the human brain Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-04-12 Evelina Fedorenko, Anna A. Ivanova, Tamar I. Regev
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Adaptive coding of reward in schizophrenia, its change over time and relation to apathy Brain (IF 14.5) Pub Date : 2024-04-12 Mariia Kaliuzhna, Fabien Carruzzo, Noémie Kuenzi, Philippe N Tobler, Matthias Kirschner, Tal Geffen, Teresa Katthagen, Kerem Böge, Marco M Zierhut, Florian Schlagenhauf, Stefan Kaiser
Adaptive coding of reward is the process by which neurons adapt their response to the context of available compensations. Higher rewards lead to a stronger brain response, but the increase of the response depends on the range of available rewards. A steeper increase is observed in a narrow range, and a more gradual slope in a wider range. In schizophrenia, adaptive coding appears affected in different
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Insula->Amygdala and Insula->Thalamus Pathways Are Involved in Comorbid Chronic Pain and Depression-Like Behavior in Mice J. Neurosci. (IF 5.3) Pub Date : 2024-04-10 Jing Chen, Yuan Gao, Shu-Ting Bao, Ying-Di Wang, Tao Jia, Cui Yin, Cheng Xiao, Chunyi Zhou
The comorbidity of chronic pain and depression poses tremendous challenges for the treatment of either one because they exacerbate each other with unknown mechanisms. As the posterior insular cortex (PIC) integrates multiple somatosensory and emotional information and is implicated in either chronic pain or depression, we hypothesize that the PIC and its projections may contribute to the pathophysiology
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Focal Brain Lesions Causing Acquired Amusia Map to a Common Brain Network J. Neurosci. (IF 5.3) Pub Date : 2024-04-10 Aleksi J. Sihvonen, Michael A. Ferguson, Vicky Chen, Seppo Soinila, Teppo Särkämö, Juho Joutsa
Music is a universal human attribute. The study of amusia, a neurologic music processing deficit, has increasingly elaborated our view on the neural organization of the musical brain. However, lesions causing amusia occur in multiple brain locations and often also cause aphasia, leaving the distinct neural networks for amusia unclear. Here, we utilized lesion network mapping to identify these networks
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RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons J. Neurosci. (IF 5.3) Pub Date : 2024-04-10 Masuma Akter, Haochen Cui, Md Abir Hosain, Jinmei Liu, Yuntian Duan, Baojin Ding
DYT1 dystonia is a debilitating neurological movement disorder, and it represents the most frequent and severe form of hereditary primary dystonia. There is currently no cure for this disease due to its unclear pathogenesis. In our previous study utilizing patient-specific motor neurons (MNs), we identified distinct cellular deficits associated with the disease, including a deformed nucleus, disrupted