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Coding corners Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-03-14 Katherine Whalley
Neurons in the mouse subiculum encode concave and convex geometrical environmental features.
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Natural language instructions induce compositional generalization in networks of neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-18 Reidar Riveland, Alexandre Pouget
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Barriers and brain fog Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-03-14 Sian Lewis
One of the long-term sequelae associated with SARS-CoV-2 infection is ‘brain fog’, which is shown in this study to be linked to systemic inflammation and leakiness of the blood–brain barrier.
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Local origin of excitatory–inhibitory tuning equivalence in a cortical network Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-15 Adrian J. Duszkiewicz, Pierre Orhan, Sofia Skromne Carrasco, Eleanor H. Brown, Eliott Owczarek, Gilberto R. Vite, Emma R. Wood, Adrien Peyrache
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How the brain’s primary processing units compute to give rise to intelligence Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-03-13 Ning-long Xu
Ning-long Xu discusses a 1999 paper that outlined a mechanism by which cortical pyramidal neurons integrate layer-specific inputs.
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Whole genome sequencing increases the diagnostic rate in Charcot-Marie-Tooth disease Brain (IF 14.5) Pub Date : 2024-03-14 Christopher J Record, Menelaos Pipis, Mariola Skorupinska, Julian Blake, Roy Poh, James M Polke, Kelly Eggleton, Tina Nanji, Stephan Zuchner, Andrea Cortese, Henry Houlden, Alexander M Rossor, Matilde Laura, Mary M Reilly
Charcot-Marie-Tooth disease (CMT) is one of the most common and genetically heterogeneous inherited neurological diseases, with more than 130 disease-causing genes. Whole genome sequencing (WGS) has improved diagnosis across genetic diseases, but the diagnostic impact in CMT is yet to be fully reported. We present the diagnostic results from a single specialist inherited neuropathy centre, including
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GABAergic Inhibition Controls Receptive Field Size, Sensitivity, and Contrast Preference of Direction Selective Retinal Ganglion Cells Near the Threshold of Vision J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Suva Roy, Xiaoyang Yao, Jay Rathinavelu, Greg D. Field
Information about motion is encoded by direction-selective retinal ganglion cells (DSGCs). These cells reliably transmit this information across a broad range of light levels, spanning moonlight to sunlight. Previous work indicates that adaptation to low light levels causes heterogeneous changes to the direction tuning of ON–OFF (oo)DSGCs and suggests that superior-preferring ON–OFF DSGCs (s-DSGCs)
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ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Bibhuti Ballav Saikia, Saurav Bhowmick, Anitha Malat, M. R. Preetha Rani, Almas Thaha, P. M. Abdul-Muneer
Intercellular adhesion molecule-1 (ICAM-1) is identified as an initiator of neuroinflammatory responses that lead to neurodegeneration and cognitive and sensory–motor deficits in several pathophysiological conditions including traumatic brain injury (TBI). However, the underlying mechanisms of ICAM-1–mediated leukocyte adhesion and transmigration and its link with neuroinflammation and functional deficits
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Intracranial Recordings of the Human Orbitofrontal Cortical Activity during Self-Referential Episodic and Valenced Self-Judgments J. Neurosci. (IF 5.3) Pub Date : 2024-03-13
We recorded directly from the orbital (oPFC) and ventromedial (vmPFC) subregions of the orbitofrontal cortex (OFC) in 22 (9 female, 13 male) epilepsy patients undergoing intracranial electroencephalography (iEEG) monitoring during an experimental task in which the participants judged the accuracy of self-referential autobiographical statements as well as valenced self-judgments (SJs). We found significantly
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Striatal and Behavioral Responses to Reward Vary by Socioeconomic Status in Adolescents J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Alexandra L. Decker, Steven L. Meisler, Nicholas A. Hubbard, Clemens C. C. Bauer, Julia Leonard, Hannah Grotzinger, Melissa A. Giebler, Yesi Camacho Torres, Andrea Imhof, Rachel Romeo, John D. E. Gabrieli
Disparities in socioeconomic status (SES) lead to unequal access to financial and social support. These disparities are believed to influence reward sensitivity, which in turn are hypothesized to shape how individuals respond to and pursue rewarding experiences. However, surprisingly little is known about how SES shapes reward sensitivity in adolescence. Here, we investigated how SES influenced adolescent
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Enhancement of Haloperidol-Induced Catalepsy by GPR143, an L-Dopa Receptor, in Striatal Cholinergic Interneurons J. Neurosci. (IF 5.3) Pub Date : 2024-03-13
Dopamine neurons play crucial roles in pleasure, reward, memory, learning, and fine motor skills and their dysfunction is associated with various neuropsychiatric diseases. Dopamine receptors are the main target of treatment for neurologic and psychiatric disorders. Antipsychotics that antagonize the dopamine D2 receptor (DRD2) are used to alleviate the symptoms of these disorders but may also sometimes
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Beyond a Transmission Cable--New Technologies to Reveal the Richness in Axonal Electrophysiology J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 J. C. Mateus, M. M. Sousa, J. Burrone, P. Aguiar
The axon is a neuronal structure capable of processing, encoding, and transmitting information. This assessment contrasts with a limiting, but deeply rooted, perspective where the axon functions solely as a transmission cable of somatodendritic activity, sending signals in the form of stereotypical action potentials. This perspective arose, at least partially, because of the technical difficulties
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Separation of Oral Cooling and Warming Requires TRPM8 J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Jinrong Li, Kyle T. Zumpano, Christian H. Lemon
Cooling sensations arise inside the mouth during ingestive and homeostasis behaviors. Oral presence of cooling temperature engages the cold and menthol receptor TRPM8 (transient receptor potential melastatin 8) on trigeminal afferents. Yet, how TRPM8 influences brain and behavioral responses to oral temperature is undefined. Here we used in vivo neurophysiology to record action potentials stimulated
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Activating Lobule VI PCTH+-Med Pathway in Cerebellum Blocks the Acquisition of Methamphetamine Conditioned Place Preference in Mice J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Feifei Ge, Zilin Wang, Wen Yu, Xiya Yuan, Qinglong Cai, Guanxiong Wang, Xiang Li, Xing Xu, Ping Yang, Yu Fan, Jiasong Chang, Xiaowei Guan
Cerebellum has been implicated in drug addiction; however, its underlying cellular populations and neuronal circuitry remain largely unknown. In the current study, we identified a neural pathway from tyrosine hydroxylase (TH)–positive Purkinje cells (PCTH+) in cerebellar lobule VI to calcium/calmodulin-dependent protein kinase II (CaMKII)–positive glutamatergic neurons in the medial cerebellar nucleus
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Cross-Modal Interactions Between Auditory Attention and Oculomotor Control J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Sijia Zhao, Claudia Contadini-Wright, Maria Chait
Microsaccades are small, involuntary eye movements that occur during fixation. Their role is debated with recent hypotheses proposing a contribution to automatic scene sampling. Microsaccadic inhibition (MSI) refers to the abrupt suppression of microsaccades, typically evoked within 0.1 s after new stimulus onset. The functional significance and neural underpinnings of MSI are subjects of ongoing research
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Movement-Related Modulation in Mouse Auditory Cortex Is Widespread Yet Locally Diverse J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Karin Morandell, Audrey Yin, Rodrigo Triana Del Rio, David M. Schneider
Neurons in the mouse auditory cortex are strongly influenced by behavior, including both suppression and enhancement of sound-evoked responses during movement. The mouse auditory cortex comprises multiple fields with different roles in sound processing and distinct connectivity to movement-related centers of the brain. Here, we asked whether movement-related modulation in male mice might differ across
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Cortical Zinc Signaling Is Necessary for Changes in Mouse Pupil Diameter That Are Evoked by Background Sounds with Different Contrasts J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Patrick Cody, Manoj Kumar, Thanos Tzounopoulos
Luminance-independent changes in pupil diameter (PD) during wakefulness influence and are influenced by neuromodulatory, neuronal, and behavioral responses. However, it is unclear whether changes in neuromodulatory activity in a specific brain area are necessary for the associated changes in PD or whether some different mechanisms cause parallel fluctuations in both PD and neuromodulation. To answer
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Transcranial Low-Intensity Focused Ultrasound Stimulation of the Visual Thalamus Produces Long-Term Depression of Thalamocortical Synapses in the Adult Visual Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Lukas Mesik, Samuel Parkins, Daniel Severin, Bryce D. Grier, Gabrielle Ewall, Sumasri Kotha, Christian Wesselborg, Cristian Moreno, Yanis Jaoui, Adrianna Felder, Brian Huang, Marina B. Johnson, Timothy P. Harrigan, Anna E. Knight, Shane W. Lani, Théo Lemaire, Alfredo Kirkwood, Grace M. Hwang, Hey-Kyoung Lee
Transcranial focused ultrasound stimulation (tFUS) is a noninvasive neuromodulation technique, which can penetrate deeper and modulate neural activity with a greater spatial resolution (on the order of millimeters) than currently available noninvasive brain stimulation methods, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). While there are several
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Dopamine D1-Receptor Organization Contributes to Functional Brain Architecture J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Robin Pedersen, Jarkko Johansson, Kristin Nordin, Anna Rieckmann, Anders Wåhlin, Lars Nyberg, Lars Bäckman, Alireza Salami
Recent work has recognized a gradient-like organization in cortical function, spanning from primary sensory to transmodal cortices. It has been suggested that this axis is aligned with regional differences in neurotransmitter expression. Given the abundance of dopamine D1-receptors (D1DR), and its importance for modulation and neural gain, we tested the hypothesis that D1DR organization is aligned
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PI4KIII{beta}-Mediated Phosphoinositides Metabolism Regulates Function of the VTA Dopaminergic Neurons and Depression-Like Behavior J. Neurosci. (IF 5.3) Pub Date : 2024-03-13 Yuqi Sang, Chenxu Niu, Jiaxi Xu, Tiantian Zhu, Shuangzhu You, Jing Wang, Ludi Zhang, Xiaona Du, Hailin Zhang
Phosphoinositides, including phosphatidylinositol-4,5-bisphosphate (PIP2), play a crucial role in controlling key cellular functions such as membrane and vesicle trafficking, ion channel, and transporter activity. Phosphatidylinositol 4-kinases (PI4K) are essential enzymes in regulating the turnover of phosphoinositides. However, the functional role of PI4Ks and mediated phosphoinositide metabolism
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Real-time analysis of large-scale neuronal imaging enables closed-loop investigation of neural dynamics Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11 Chun-Feng Shang, Yu-Fan Wang, Mei-Ting Zhao, Qiu-Xiang Fan, Shan Zhao, Yu Qian, Sheng-Jin Xu, Yu Mu, Jie Hao, Jiu-Lin Du
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Dominant CST3 variants cause adult onset leukodystrophy without amyloid angiopathy Brain (IF 14.5) Pub Date : 2024-03-13 Caroline G Bergner, Marjolein Breur, M Clara Soto-Bernardini, Lisa Schäfer, Julia Lier, Diana Le Duc, Linnaeus Bundalian, Susanna Schubert, David Brenner, Friedmar R Kreuz, Björn Schulte, Quinten Waisfisz, Marianna Bugiani, Wolfgang Köhler, Heinrich Sticht, Rami Abou Jamra, Marjo S van der Knaap
Leukodystrophies are rare genetic white matter disorders that have been regarded as mainly occurring in childhood. Recent years altered this perception, as a growing number of leukodystrophies was described to have an onset at adult ages. Still, many adult patients presenting with white matter changes remain without a specific molecular diagnosis. We describe a novel adult onset leukodystrophy in 16
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Digenic Leigh syndrome on the background of the m.11778G>A Leber hereditary optic neuropathy variant Brain (IF 14.5) Pub Date : 2024-03-13 Beryll Blickhäuser, Sarah L Stenton, Christiane M Neuhofer, Elisa Floride, Victoria Nesbitt, Carl Fratter, Johannes Koch, Birgit Kauffmann, Claudia Catarino, Lea Dewi Schlieben, Robert Kopajtich, Valerio Carelli, Alfredo A Sadun, Robert McFarland, Fang Fang, Chiara La Morgia, Stéphanie Paquay, Marie Cécile Nassogne, Daniele Ghezzi, Costanza Lamperti, Saskia Wortmann, Jo Poulton, Thomas Klopstock, Holger
Leigh syndrome spectrum (LSS) is a primary mitochondrial disorder defined neuropathologically by a subacute necrotizing encephalomyelopathy and characterised by bilateral basal ganglia and/or brainstem lesions. LSS is associated with variants in several mitochondrial DNA (mtDNA) genes and more than 100 nuclear genes, most often related to mitochondrial complex I (CI) dysfunction. Rarely, LSS has been
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Paroxysmal dystonia results from the loss of RIM4 in Purkinje cells Brain (IF 14.5) Pub Date : 2024-03-13 Hyuntae Kim, Nesrine Melliti, Eva Breithausen, Katrin Michel, Sara Ferrando Colomer, Ekaterina Poguzhelskaya, Paulina Nemcova, Laura Ewell, Sandra Blaess, Albert Becker, Julika Pitsch, Dirk Dietrich, Susanne Schoch
Full-length RIM1 and 2 are key components of the presynaptic active zone that ubiquitously control excitatory and inhibitory neurotransmitter release. Here, we report that the function of the small RIM isoform RIM4, consisting of a single C2 domain, is strikingly different from that of the long isoforms. RIM4 is dispensable for neurotransmitter release but plays a postsynaptic, cell-type specific role
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In conversation with Igor Adameyko Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-12 Elisa Floriddia
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved, and where it is heading. This month, we are talking to Igor Adameyko (Department Chair at the Center for Brain Research of the Medical University of Vienna, Austria, and a group leader at the Karolinska
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Liprin-α proteins are master regulators of human presynapse assembly Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-12 Berta Marcó de la Cruz, Joaquín Campos, Angela Molinaro, Xingqiao Xie, Gaowei Jin, Zhiyi Wei, Claudio Acuna, Fredrik H. Sterky
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Identification of a cold sensor in peripheral somatosensory neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11
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The kainate receptor GluK2 mediates cold sensing in mice Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-11 Wei Cai, Wenwen Zhang, Qin Zheng, Chia Chun Hor, Tong Pan, Mahar Fatima, Xinzhong Dong, Bo Duan, X. Z. Shawn Xu
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Fear bypasses the amygdala Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-03-08 Sian Lewis
Innate fear-like responses are thought to involve the amygdala, but here a tetra-synaptic pathway is identified that mediates odour-evoked innate fear in mice.
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Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration Brain (IF 14.5) Pub Date : 2024-03-08 Fengfei Ding, Qian Sun, Carter Long, Rune Nguyen Rasmussen, Sisi Peng, Qiwu Xu, Ning Kang, Wei Song, Pia Weikop, Steven A Goldman, Maiken Nedergaard
Progressive neuronal loss is a hallmark feature distinguishing neurodegenerative diseases from normal aging. However, the underlying mechanisms remain unknown. Extracellular K+ homeostasis is a potential mediator of neuronal injury since K+ elevations increase excitatory activity. The dysregulation of extracellular K+ and potassium channel expressions during neurodegeneration could contribute to this
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The clinical and genetic spectrum of inherited glycosylphosphatidylinositol deficiency disorders Brain (IF 14.5) Pub Date : 2024-03-08 Jai Sidpra, Sniya Sudhakar, Asthik Biswas, Flavia Massey, Valentina Turchetti, Tracy Lau, Edward Cook, Javeria Raza Alvi, Hasnaa M Elbendary, Jerry L Jewell, Antonella Riva, Alessandro Orsini, Aglaia Vignoli, Zara Federico, Jessica Rosenblum, An-Sofie Schoonjans, Matthias de Wachter, Ignacio Delgado Alvarez, Ana Felipe-Rucián, Nourelhoda A Haridy, Shahzad Haider, Mashaya Zaman, Selina Banu, Najwa Anwaar
Inherited glycosylphosphatidylinositol deficiency disorders (IGDs) are a group of rare multisystem disorders arising from pathogenic variants in glycosylphosphatidylinositol anchor pathway (GPI-AP) genes. Despite associating 24 of at least 31 GPI-AP genes with human neurogenetic disease, prior reports are limited to single genes without consideration of the GPI-AP as a whole and with limited natural
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Learning with baby Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Rebecca Wright
The rate at which young children learn new words astounds care-givers and scientists alike. Most models of early language acquisition have only been tested in laboratory settings using highly controlled stimuli. In a recent publication in Science, Vong et al. decided to take a more naturalistic approach. They collected 61 h of video footage of a toddler wearing a head-mounted camera as they went about
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The eyes have it Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Leonie Welberg
Many social species use eye contact to guide social behaviors. To study how visual cues shape social decision making, Franch et al. wirelessly recorded eye movements and activity in the visual and prefrontal cortices in two pairs of freely moving macaque monkeys. To retrieve food rewards, paired monkeys — who could see each other through a transparent screen — each had to press and hold a button and
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Slowing human neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-07 Shari Wiseman
Human neurodevelopment is slower than that of other mammalian species, and this timescale appears to be intrinsic to human neural cells. However, not much is known about the mechanisms that govern this maturational timing. In a recent paper in Nature, Ciceri et al. developed a human pluripotent stem cell culture protocol that synchronously generates a uniform population of cortical neurons. The authors
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A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer’s disease vulnerable neurons Brain (IF 14.5) Pub Date : 2024-03-07 Patricia Rodriguez-Rodriguez, Luis Enrique Arroyo-Garcia, Christina Tsagkogianni, Lechuan Li, Wei Wang, Ákos Végvári, Isabella Salas-Allende, Zakary Plautz, Angel Cedazo-Minguez, Subhash C Sinha, Olga Troyanskaya, Marc Flajolet, Vicky Yao, Jean-Pierre Roussarie
Neurons from layer II of the entorhinal cortex (ECII) are the first to accumulate tau protein aggregates and degenerate during prodromal Alzheimer’s disease (AD). Gaining insight into the molecular mechanisms underlying this vulnerability will help reveal genes and pathways at play during incipient stages of the disease. Here, we use a data-driven functional genomics approach to model ECII neurons
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Preparatory activity and the expansive null-space Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-03-05 Mark M. Churchland, Krishna V. Shenoy
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Overnight neuronal plasticity and adaptation to emotional distress Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-03-05 Yesenia Cabrera, Karin J. Koymans, Gina R. Poe, Helmut W. Kessels, Eus J. W. Van Someren, Rick Wassing
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Different Effects of Peer Sex on Operant Responding for Social Interaction and Striatal Dopamine Activity J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Jonathan J. Chow, Kayla M. Pitts, Ansel Schoenbaum, Kauê M. Costa, Geoffrey Schoenbaum, Yavin Shaham
When rats are given discrete choices between social interactions with a peer and opioid or psychostimulant drugs, they choose social interaction, even after extensive drug self-administration experience. Studies show that like drug and nondrug food reinforcers, social interaction is an operant reinforcer and induces dopamine release. However, these studies were conducted with same-sex peers. We examined
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Parvalbumin and Somatostatin: Biomarkers for Two Parallel Tectothalamic Pathways in the Auditory Midbrain J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Mengting Liu, Yixiao Gao, Fengyuan Xin, Ying Hu, Tao Wang, Fenghua Xie, Chengjun Shao, Tianyu Li, Ningyu Wang, Kexin Yuan
The inferior colliculus (IC) represents a crucial relay station in the auditory pathway, located in the midbrain's tectum and primarily projecting to the thalamus. Despite the identification of distinct cell classes based on various biomarkers in the IC, their specific contributions to the organization of auditory tectothalamic pathways have remained poorly understood. In this study, we demonstrate
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Pre- versus Post-synaptic Forms of LTP in Two Branches of the Same Hippocampal Afferent J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 J. Quintanilla, Y. Jia, B. S. Pruess, J. Chavez, C. M. Gall, G. Lynch, B. G. Gunn
There has been considerable controversy about pre- versus postsynaptic expression of memory-related long-term potentiation (LTP), with corresponding disputes about underlying mechanisms. We report here an instance in male mice, in which both types of potentiation are expressed but in separate branches of the same hippocampal afferent. Induction of LTP in the dentate gyrus (DG) branch of the lateral
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Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Josue A. Lopez, Luis O. Romero, Wai-Lin Kaung, J. Wesley Maddox, Valeria Vásquez, Amy Lee
The sense of touch is crucial for cognitive, emotional, and social development and relies on mechanically activated (MA) ion channels that transduce force into an electrical signal. Despite advances in the molecular characterization of these channels, the physiological factors that control their activity are poorly understood. Here, we used behavioral assays, electrophysiological recordings, and various
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Oscillatory Waveform Shape and Temporal Spike Correlations Differ across Bat Frontal and Auditory Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Francisco García-Rosales, Natalie Schaworonkow, Julio C. Hechavarria
Neural oscillations are associated with diverse computations in the mammalian brain. The waveform shape of oscillatory activity measured in the cortex relates to local physiology and can be informative about aberrant or dynamically changing states. However, how waveform shape differs across distant yet functionally and anatomically related cortical regions is largely unknown. In this study, we capitalize
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Cumulative Effects of Resting-State Connectivity Across All Brain Networks Significantly Correlate with Attention-Deficit Hyperactivity Disorder Symptoms J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Michael A. Mooney, Robert J. M. Hermosillo, Eric Feczko, Oscar Miranda-Dominguez, Lucille A. Moore, Anders Perrone, Nora Byington, Gracie Grimsrud, Amanda Rueter, Elizabeth Nousen, Dylan Antovich, Sarah W. Feldstein Ewing, Bonnie J. Nagel, Joel T. Nigg, Damien A. Fair
Identification of replicable neuroimaging correlates of attention-deficit hyperactivity disorder (ADHD) has been hindered by small sample sizes, small effects, and heterogeneity of methods. Given evidence that ADHD is associated with alterations in widely distributed brain networks and the small effects of individual brain features, a whole-brain perspective focusing on cumulative effects is warranted
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A Necessary Role for PKC-2 and TPA-1 in Olfactory Memory and Synaptic AMPAR Trafficking in Caenorhabditis elegans J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Attila L. Stetak, Thomas Grenal, Zephyr Lenninger, Kaz M. Knight, Rachel L. Doser, Frederic J. Hoerndli
Protein kinase C (PKC) functions are essential for synaptic plasticity, learning, and memory. However, the roles of specific members of the PKC family in synaptic function, learning, and memory are poorly understood. Here, we investigated the role of individual PKC homologs for synaptic plasticity in Caenorhabditis elegans and found a differential role for pkc-2 and tpa-1, but not pkc-1 and pkc-3 in
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Dissociable Roles of the Auditory Midbrain and Cortex in Processing the Statistical Features of Natural Sound Textures J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Fei Peng, Nicol S. Harper, Ambika P. Mishra, Ryszard Auksztulewicz, Jan W. H. Schnupp
Sound texture perception takes advantage of a hierarchy of time-averaged statistical features of acoustic stimuli, but much remains unclear about how these statistical features are processed along the auditory pathway. Here, we compared the neural representation of sound textures in the inferior colliculus (IC) and auditory cortex (AC) of anesthetized female rats. We recorded responses to texture morph
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Neural Circuits Underlying Multifeature Extraction in the Retina J. Neurosci. (IF 5.3) Pub Date : 2024-03-06
Classic ON–OFF direction-selective ganglion cells (DSGCs) that encode the four cardinal directions were recently shown to also be orientation-selective. To clarify the mechanisms underlying orientation selectivity, we employed a variety of electrophysiological, optogenetic, and gene knock-out strategies to test the relative contributions of glutamate, GABA, and acetylcholine (ACh) input that are known
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Attention Drives Visual Processing and Audiovisual Integration During Multimodal Communication J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Noor Seijdel, Jan-Mathijs Schoffelen, Peter Hagoort, Linda Drijvers
During communication in real-life settings, our brain often needs to integrate auditory and visual information and at the same time actively focus on the relevant sources of information, while ignoring interference from irrelevant events. The interaction between integration and attention processes remains poorly understood. Here, we use rapid invisible frequency tagging and magnetoencephalography to
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The Anterior Thalamus Preferentially Drives Allocentric But Not Egocentric Orientation Tuning in Postrhinal Cortex J. Neurosci. (IF 5.3) Pub Date : 2024-03-06
Navigating a complex world requires integration of multiple spatial reference frames, including information about one's orientation in both allocentric and egocentric coordinates. Combining these two information sources can provide additional information about one's spatial location. Previous studies have demonstrated that both egocentric and allocentric spatial signals are reflected by the firing
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Event Integration and Temporal Differentiation: How Hierarchical Knowledge Emerges in Hippocampal Subfields through Learning J. Neurosci. (IF 5.3) Pub Date : 2024-03-06
Everyday life is composed of events organized by changes in contexts, with each event containing an unfolding sequence of occurrences. A major challenge facing our memory systems is how to integrate sequential occurrences within events while also maintaining their details and avoiding over-integration across different contexts. We asked if and how distinct hippocampal subfields come to hierarchically
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Divergent Learning-Related Transcriptional States of Cortical Glutamatergic Neurons J. Neurosci. (IF 5.3) Pub Date : 2024-03-06 Katie L. Dunton, Nathan G. Hedrick, Saber Meamardoost, Chi Ren, James R. Howe, Jing Wang, Cory M. Root, Rudiyanto Gunawan, Takaki Komiyama, Ying Zhang, Eun Jung Hwang
Experience-dependent gene expression reshapes neural circuits, permitting the learning of knowledge and skills. Most learning involves repetitive experiences during which neurons undergo multiple stages of functional and structural plasticity. Currently, the diversity of transcriptional responses underlying dynamic plasticity during repetition-based learning is poorly understood. To close this gap
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Sex differences in the pleiotropy of hearing difficulty with imaging-derived phenotypes: a brain-wide investigation Brain (IF 14.5) Pub Date : 2024-03-06 Jun He, Brenda Cabrera-Mendoza, Flavio De Angelis, Gita A Pathak, Dora Koller, Sharon G Curhan, Gary C Curhan, Adam P Mecca, Christopher H van Dyck, Renato Polimanti
Hearing difficulty (HD) is one of the major health burdens in older adults. While aging-related changes in the peripheral auditory system play an important role, genetic variation associated with brain structure and function could also be involved in HD predisposition. We analyzed a large-scale HD genome-wide association study (GWAS; Ntotal = 501,825, 56% females) and GWAS data related to 3,935 brain
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Synaptopathy: presynaptic convergence in frontotemporal dementia and amyotrophic lateral sclerosis Brain (IF 14.5) Pub Date : 2024-03-06 Emma L Clayton, Laura Huggon, Michael A Cousin, Sarah Mizielinska
Frontotemporal dementia and amyotrophic lateral sclerosis are common forms of neurodegenerative disease which share overlapping genetics and pathologies. Crucially, no significantly disease-modifying treatments are available for either disease. Identifying the earliest changes which initiate neuronal dysfunction is important for designing effective intervention therapeutics. The genes mutated in genetic
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MMP8 and stress susceptibility Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-03-04 Darran Yates
Increased levels of matrix metalloproteinase 8, expressed by circulating myeloid cells, may have a role in stress-induced changes in social behaviour in mice.
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Population coding of strategic variables during foraging in freely moving macaques Nat. Neurosci. (IF 25.0) Pub Date : 2024-03-05 Neda Shahidi, Melissa Franch, Arun Parajuli, Paul Schrater, Anthony Wright, Xaq Pitkow, Valentin Dragoi
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Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection Brain (IF 14.5) Pub Date : 2024-03-05 Marianna Spatola, Nadège Nziza, Edward B Irvine, Deniz Cizmeci, Wonyeong Jung, Le Hong Van, Le Thanh Hoang Nhat, Vu Thi Ngoc Ha, Nguyen Hoan Phu, Ho Dang Trung Nghia, Guy Thwaites, Douglas A Lauffenburger, Sarah Fortune, Nguyen Thuy Thuong Thuong, Galit Alter
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a global health burden. While Mtb is primarily a respiratory pathogen, it can spread to other organs, including the brain and meninges, causing TB meningitis (TBM). However, little is known about the immunological mechanisms that leads to differential disease across organs. Attention has focused on differences in T
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Social representation Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2024-03-04 Katherine Whalley
Populations of neurons in the mouse hippocampus use distinct representational strategies to encode familiarity and episodic social memory.
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Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia Brain (IF 14.5) Pub Date : 2024-03-04 Ana Paula Nascimento de Lima, Huiran Zhang, Lubin Chen, Philip R Effraim, Carolina Gomis-Perez, Xiaoyang Cheng, Jianying Huang, Stephen G Waxman, Sulayman D Dib-Hajj
Vincristine-induced peripheral neuropathy (VIPN) is a common side effect of vincristine treatment, which is accompanied by pain and can be dose-limiting. The molecular mechanisms that underlie vincristine-induced pain are not well understood. We have established an animal model to investigate pathophysiological mechanisms of vincristine induced pain. Our previous studies have shown that the tetrodotoxin-sensitive
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The human subthalamic nucleus transiently inhibits active attentional processes Brain (IF 14.5) Pub Date : 2024-03-04 Cheol Soh, Mario Hervault, Nathan H Chalkley, Cathleen M Moore, Andrea Rohl, Qiang Zhang, Ergun Y Uc, Jeremy D W Greenlee, Jan R Wessel
The subthalamic nucleus (STN) of the basal ganglia is key to the inhibitory control of movement. Consequently, it is a primary target for the neurosurgical treatment of movement disorders like Parkinson’s Disease, where modulating the STN via deep-brain stimulation (DBS) can release excess inhibition of thalamo-cortical motor circuits. However, the STN is also anatomically connected to other thalamo-cortical
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The silence of the reactive astrocytes Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-29 Francesco Limone, Shane Liddelow
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PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons Nat. Neurosci. (IF 25.0) Pub Date : 2024-02-29 Carmelo Milioto, Mireia Carcolé, Ashling Giblin, Rachel Coneys, Olivia Attrebi, Mhoriam Ahmed, Samuel S. Harris, Byung Il Lee, Mengke Yang, Robert A. Ellingford, Raja S. Nirujogi, Daniel Biggs, Sally Salomonsson, Matteo Zanovello, Paula de Oliveira, Eszter Katona, Idoia Glaria, Alla Mikheenko, Bethany Geary, Evan Udine, Deniz Vaizoglu, Sharifah Anoar, Khrisha Jotangiya, Gerard Crowley, Demelza M. Smeeth