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Functional architecture of dopamine neurons driving fear extinction learning Neuron (IF 16.2) Pub Date : 2023-09-22 Ximena I. Salinas-Hernández, Daphne Zafiri, Torfi Sigurdsson, Sevil Duvarci
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Accelerating scientific progress through Bayesian adversarial collaboration Neuron (IF 16.2) Pub Date : 2023-09-21 Andrew W. Corcoran, Jakob Hohwy, Karl J. Friston
Adversarial collaboration has been championed as the gold standard for resolving scientific disputes but has gained relatively limited traction in neuroscience and allied fields. In this perspective, we argue that adversarial collaborative research has been stymied by an overly restrictive concern with the falsification of scientific theories. We advocate instead for a more expansive view that frames
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Prefrontal cortical regulation of REM sleep Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-21 Jiso Hong, David E. Lozano, Kevin T. Beier, Shinjae Chung, Franz Weber
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Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders Brain (IF 14.5) Pub Date : 2023-09-22 Chuan Qin, Man Chen, Ming-Hao Dong, Sheng Yang, Hang Zhang, Yun-Fan You, Luo-Qi Zhou, Yun-Hui Chu, Yue Tang, Xiao-Wei Pang, Long-Jun Wu, Dai-Shi Tian, Wei Wang
Microglia-mediated neuroinflammation contributes to acute demyelination in neuromyelitis optica spectrum disorders (NMOSD). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in the cerebrospinal fluid (CSF) has been associated with microglial activation in several neurodegenerative diseases. However, the basis for this immune-mediated attack and the pathophysiological role of sTREM2
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Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis Neuron (IF 16.2) Pub Date : 2023-09-21 Svenja Bolz, Natalie Kaempf, Dmytro Puchkov, Michael Krauss, Giulia Russo, Tolga Soykan, Christopher Schmied, Martin Lehmann, Rainer Müller, Carsten Schultz, David Perrais, Tanja Maritzen, Volker Haucke
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Painspotting Neuron (IF 16.2) Pub Date : 2023-09-20 Donald Iain MacDonald, Alexander T. Chesler
How do we know an animal is feeling pain? In this issue of Neuron, Bohic et al.1 develop computational methods to detect pain in mice, shining a light on the behavioral changes that occur during pain, its relief, and recovery.
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Overcoming blood-brain barrier for targeted delivery of lysosome-targeting chimeras Neuron (IF 16.2) Pub Date : 2023-09-20 Qiang Cai, Quazi T.H. Shubhra
In a recent Chem article, Liu et al.1 introduced polydopamine-based lysosome-targeting chimeras (KPLYs). In in vitro cellular models, KPLYs adeptly cross the blood-brain barrier to target and eliminate β-amyloid aggregates. They also reduce inflammation and modulate microglial activity.
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Perturbed Information Processing Complexity in Experimental Epilepsy J. Neurosci. (IF 5.3) Pub Date : 2023-09-20
Comorbidities, such as cognitive deficits, which often accompany epilepsies, constitute a basal state, while seizures are rare and transient events. This suggests that neural dynamics, in particular those supporting cognitive function, are altered in a permanent manner in epilepsy. Here, we test the hypothesis that primitive processes of information processing at the core of cognitive function (i.e
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Distinct Lateral Prefrontal Regions Are Organized in an Anterior-Posterior Functional Gradient J. Neurosci. (IF 5.3) Pub Date : 2023-09-20 Pin Kwang Tan, Cheng Tang, Roger Herikstad, Arunika Pillay, Camilo Libedinsky
The dorsolateral prefrontal cortex (dlPFC) is composed of multiple anatomically defined regions involved in higher-order cognitive processes, including working memory and selective attention. It is organized in an anterior–posterior global gradient where posterior regions track changes in the environment, whereas anterior regions support abstract neural representations. However, it remains unknown
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Effect of Alzheimer's Pathology on Task-Related Brain Network Reconfiguration in Aging J. Neurosci. (IF 5.3) Pub Date : 2023-09-20
Large-scale brain networks undergo widespread changes with older age and in neurodegenerative diseases such as Alzheimer's disease (AD). Research in young adults (YA) suggest that the underlying functional architecture of brain networks remains relatively consistent between rest and task states. However, it remains unclear whether the same is true in aging and to what extent any changes may be related
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Switching between External and Internal Attention in Hippocampal Networks J. Neurosci. (IF 5.3) Pub Date : 2023-09-20 Craig Poskanzer, Mariam Aly
Everyday experience requires processing external signals from the world around us and internal information retrieved from memory. To do both, the brain must fluctuate between states that are optimized for external versus internal attention. Here, we focus on the hippocampus as a region that may serve at the interface between these forms of attention and ask how it switches between prioritizing sensory
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Adding Meaning to Memories: How Parietal Cortex Combines Semantic Content with Episodic Experience J. Neurosci. (IF 5.3) Pub Date : 2023-09-20 Hongmi Lee, Paul A. Keene, Sarah C. Sweigart, J. Benjamin Hutchinson, Brice A. Kuhl
Neuroimaging studies of human memory have consistently found that univariate responses in parietal cortex track episodic experience with stimuli (whether stimuli are 'old' or 'new'). More recently, pattern-based fMRI studies have shown that parietal cortex also carries information about the semantic content of remembered experiences. However, it is not well understood how memory-based and content-based
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Neural Representations in Visual and Parietal Cortex Differentiate between Imagined, Perceived, and Illusory Experiences J. Neurosci. (IF 5.3) Pub Date : 2023-09-20 Siyi Li, Xuemei Zeng, Zhujun Shao, Qing Yu
Humans constantly receive massive amounts of information, both perceived from the external environment and imagined from the internal world. To function properly, the brain needs to correctly identify the origin of information being processed. Recent work has suggested common neural substrates for perception and imagery. However, it has remained unclear how the brain differentiates between external
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Widespread and Multifaceted Binocular Integration in the Mouse Primary Visual Cortex J. Neurosci. (IF 5.3) Pub Date : 2023-09-20
The brain combines two-dimensional images received from the two eyes to form a percept of three-dimensional surroundings. This process of binocular integration in the primary visual cortex (V1) serves as a useful model for studying how neural circuits generate emergent properties from multiple input signals. Here, we perform a thorough characterization of binocular integration using electrophysiological
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KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons J. Neurosci. (IF 5.3) Pub Date : 2023-09-20 Nissi Varghese, Bruno Moscoso, Ana Chavez, Kristen Springer, Erika Ortiz, Heun Soh, Sabato Santaniello, Atul Maheshwari, Anastasios V. Tzingounis
Gain-of-function (GOF) pathogenic variants in the potassium channels KCNQ2 and KCNQ3 lead to hyperexcitability disorders such as epilepsy and autism spectrum disorders. However, the underlying cellular mechanisms of how these variants impair forebrain function are unclear. Here, we show that the R201C variant in KCNQ2 has opposite effects on the excitability of two types of mouse pyramidal neurons
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Rewinding reward Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2023-09-20 Sian Lewis
Increasing levels of glial-derived neurotrophic factor using a gene-therapy approach in a macaque model of alcohol use disorder resulted in a lower tendency to relapse into alcohol consumption after a period of abstinence.
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Defensive responses: behaviour, the brain and the body Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2023-09-20 Yu-Ting Tseng, Bernhard Schaefke, Pengfei Wei, Liping Wang
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Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-21 Kyoko Tossell, Xiao Yu, Panagiotis Giannos, Berta Anuncibay Soto, Mathieu Nollet, Raquel Yustos, Giulia Miracca, Mikal Vicente, Andawei Miao, Bryan Hsieh, Ying Ma, Alexei L. Vyssotski, Tim Constandinou, Nicholas P. Franks, William Wisden
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A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code Neuron (IF 16.2) Pub Date : 2023-09-20 Zhengwei Yuan, Zhongyang Qi, Ruiyu Wang, Yuting Cui, Sile An, Guoli Wu, Qiru Feng, Rui Lin, Ruicheng Dai, Anan Li, Hui Gong, Qingming Luo, Ling Fu, Minmin Luo
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A cholinergic circuit that relieves pain despite opioid tolerance Neuron (IF 16.2) Pub Date : 2023-09-20 Shivang Sullere, Alissa Kunczt, Daniel S. McGehee
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Brain MRI research in neurodegenerative dementia: time to deliver on promises Brain (IF 14.5) Pub Date : 2023-09-21 Simon Ducharme
This scientific commentary refers to ‘Atrophy in behavioural variant frontotemporal dementia spans multiple large-scale prefrontal and temporal networks’ by Eldaief et al. (https://doi.org/10.1093/brain/awad167).
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In conversation with Theanne Griffith Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-18 Shari Wiseman
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how neuroscience has evolved and where it is heading. This month, we are talking to Theanne Griffith, Assistant Professor in the Department of Physiology and Membrane Biology at the University of California, Davis. We spoke about
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Adaptor protein AP-3 produces synaptic vesicles that release at high frequency by recruiting phospholipid flippase ATP8A1 Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-18 Hongfei Xu, Juan A. Oses-Prieto, Mikhail Khvotchev, Shweta Jain, Jocelyn Liang, Alma Burlingame, Robert H. Edwards
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Goal-seeking compresses neural codes for space in the human hippocampus and orbitofrontal cortex Neuron (IF 16.2) Pub Date : 2023-09-18 Paul S. Muhle-Karbe, Hannah Sheahan, Giovanni Pezzulo, Hugo J. Spiers, Samson Chien, Nicolas W. Schuck, Christopher Summerfield
Humans can navigate flexibly to meet their goals. Here, we asked how the neural representation of allocentric space is distorted by goal-directed behavior. Participants navigated an agent to two successive goal locations in a grid world environment comprising four interlinked rooms, with a contextual cue indicating the conditional dependence of one goal location on another. Examining the neural geometry
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Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch Neuron (IF 16.2) Pub Date : 2023-09-18 Annie Handler, Qiyu Zhang, Song Pang, Tri M. Nguyen, Michael Iskols, Michael Nolan-Tamariz, Stuart Cattel, Rebecca Plumb, Brianna Sanchez, Karyl Ashjian, Aria Shotland, Bartianna Brown, Madiha Kabeer, Josef Turecek, Michelle M. DeLisle, Genelle Rankin, Wangchu Xiang, Elisa C. Pavarino, Nusrat Africawala, Celine Santiago, David D. Ginty
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A view-based decision mechanism for rewards in the primate amygdala Neuron (IF 16.2) Pub Date : 2023-09-18 Fabian Grabenhorst, Adrián Ponce-Alvarez, Alexandra Battaglia-Mayer, Gustavo Deco, Wolfram Schultz
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Parkinson’s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons Neuron (IF 16.2) Pub Date : 2023-09-15 Pingping Song, Wesley Peng, Veronique Sauve, Rayan Fakih, Zhong Xie, Daniel Ysselstein, Talia Krainc, Yvette C. Wong, Niccolò E. Mencacci, Jeffrey N. Savas, D. James Surmeier, Kalle Gehring, Dimitri Krainc
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Clinical and genetic characterisation of a large Indian congenital myasthenic syndrome cohort Brain (IF 14.5) Pub Date : 2023-09-18 Kiran Polavarapu, Balaraju Sunitha, Ana Töpf, Veeramani Preethish-kumar, Rachel Thompson, Seena Vengalil, Saraswati Nashi, Mainak Bardhan, Sai Bhargava Sanka, Akshata Huddar, Gopikrishnan Unnikrishnan, Gautham Arunachal, Manu Santhappan Girija, Anna Porter, Yoshiteru Azuma, Paulo José Lorenzoni, Dipti Baskar, Ram Murthy Anjanappa, Madassu Keertipriya, Hansashree Padmanabh, Ganaraja Valakunja Harikrishna
Congenital myasthenic syndromes are a rare group of inherited disorders caused by gene defects associated with the neuromuscular junction and potentially treatable with commonly available medications such as acetylcholinesterase inhibitors and beta2 adrenergic receptor agonists. In this study we identify and genetically characterise the largest cohort of congenital myasthenic syndrome patients from
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Grey matter heterotopia subtypes show specific morpho-electric signatures and network dynamics Brain (IF 14.5) Pub Date : 2023-09-18 Jean-Christophe Vermoyal, Delphine Hardy, Lucas Goirand-Lopez, Antonin Vinck, Lucas Silvagnoli, Aurélien Fortoul, Fiona Francis, Silvia Cappello, Ingrid Bureau, Alfonso Represa, Carlos Cardoso, Françoise Watrin, Thomas Marissal, Jean-Bernard Manent
Grey matter heterotopia (GMH) are neurodevelopmental disorders associated with abnormal cortical function and epilepsy. Subcortical band heterotopia (SBH) and periventricular nodular heterotopia (PVNH) are two well-recognized GMH subtypes in which neurons are misplaced, either forming nodules lining the ventricles in PVNH, or forming bands in the white matter in SBH. Although both PVNH and SBH are
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Gut microbiome correlates with plasma lipids in amyotrophic lateral sclerosis Brain (IF 14.5) Pub Date : 2023-09-18 Kai Guo, Claudia Figueroa-Romero, Mohamed H Noureldein, Benjamin J Murdock, Masha G Savelieff, Junguk Hur, Stephen A Goutman, Eva L Feldman
Amyotrophic lateral sclerosis (ALS) is a complex, fatal neurodegenerative disease. Disease pathophysiology is incompletely understood, but evidence suggests gut dysbiosis occurs in ALS, linked to impaired gastrointestinal integrity, immune system dysregulation, and altered metabolism. Gut microbiome and plasma metabolome have been separately investigated in ALS, but little is known about gut microbe-plasma
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Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation Brain (IF 14.5) Pub Date : 2023-09-17 Emma M Coomans, Danielle van Westen, Alexa Pichet Binette, Olof Strandberg, Nicola Spotorno, Geidy E Serrano, Thomas G Beach, Sebastian Palmqvist, Erik Stomrud, Rik Ossenkoppele, Oskar Hansson
Cerebrovascular pathology often co-exists with Alzheimer’s disease pathology and can contribute to Alzheimer’s disease-related clinical progression. However, the degree to which vascular burden contributes to Alzheimer’s disease pathological progression is still unclear. This study aimed to investigate interactions between vascular burden and amyloid-β pathology on both baseline tau tangle load and
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GluN2A mediates ketamine-induced rapid antidepressant-like responses Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-14 Tonghui Su, Yi Lu, Chaoying Fu, Yang Geng, Yelin Chen
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Interoceptive rhythms in the brain Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-11 Tahnée Engelen, Marco Solcà, Catherine Tallon-Baudry
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The parietal architecture binding cognition to sensorimotor integration: a multimodal causal study Brain (IF 14.5) Pub Date : 2023-09-15 Luca Fornia, Antonella Leonetti, Guglielmo Puglisi, Marco Rossi, Luca Viganò, Bianca Della Santa, Luciano Simone, Lorenzo Bello, Gabriella Cerri
Despite human’s praxis abilities are unique among primates, comparative observations suggest that these cognitive motor skills could have emerged from exploitation and adaptation of phylogenetically older building blocks, namely the parieto-frontal networks sub-serving prehension and manipulation. Within this framework, investigating to which extent praxis and prehension-manipulation overlap and diverge
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Navigating T cell brain entry in MS Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-14 Magda Ali, Adrian Liston
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In conversation with Freda Miller Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-14 Elisa Floriddia
As Nature Neuroscience celebrates its 25th anniversary, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. This month we are talking to Freda Miller, Deputy Director and Professor of Developmental Neurobiology at University of British Columbia. She is known for her work on neuronal and
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A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-14 Arek Kendirli, Clara de la Rosa, Katrin F. Lämmle, Klara Eglseer, Isabel J. Bauer, Vladyslav Kavaka, Stephan Winklmeier, La Zhuo, Christian Wichmann, Lisa Ann Gerdes, Tania Kümpfel, Klaus Dornmair, Eduardo Beltrán, Martin Kerschensteiner, Naoto Kawakami
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Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-11 Tsai-Yi Lu, Priyanka Hanumaihgari, Eric T. Hsu, Amit Agarwal, Riki Kawaguchi, Peter A. Calabresi, Dwight E. Bergles
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Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols Nat. Neurosci. (IF 25.0) Pub Date : 2023-09-11 Paul W. Frazel, David Labib, Theodore Fisher, Ran Brosh, Nicolette Pirianian, Anne Marchildon, Jef D. Boeke, Valentina Fossati, Shane A. Liddelow
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Dietary Fiber and Microbiota Metabolite Receptors Enhance Cognition and Alleviate Disease in the 5xFAD Mouse Model of Alzheimers Disease J. Neurosci. (IF 5.3) Pub Date : 2023-09-13 Yichen Zhou, Liang Xie, Jan Schröder, Iona S. Schuster, Michael Nakai, Guizhi Sun, Yu B. Y. Sun, Eliana Mariño, Mariapia A. Degli-Esposti, Francine Z. Marques, Alexandra Grubman, Jose M. Polo, Charles R. Mackay
Alzheimer’s disease (AD) is a neurodegenerative disorder with poorly understood etiology. AD has several similarities with other "Western lifestyle" inflammatory diseases, where the gut microbiome and immune pathways have been associated. Previously, we and others have noted the involvement of metabolite-sensing GPCRs and their ligands, short-chain fatty acids (SCFAs), in protection of numerous Western
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The Influence of Prestimulus 1/f-Like versus Alpha-Band Activity on Subjective Awareness of Auditory and Visual Stimuli J. Neurosci. (IF 5.3) Pub Date : 2023-09-13 Emily Cunningham, Clementine Zimnicki, Diane M. Beck
Alpha rhythmic activity is often suggested to exert an inhibitory influence on information processing. However, relatively little is known about how reported alpha-related effects are influenced by a potential confounding element of the neural signal, power-law scaling. In the current study, we systematically examine the effect of accounting for 1/f activity on the relation between prestimulus alpha
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Neuroanatomical Disposition, Natural Development, and Training-Induced Plasticity of the Human Auditory System from Childhood to Adulthood: A 12-Year Study in Musicians and Nonmusicians J. Neurosci. (IF 5.3) Pub Date : 2023-09-13 Peter Schneider, Dorte Engelmann, Christine Groß, Valdis Bernhofs, Elke Hofmann, Markus Christiner, Jan Benner, Steffen Bücher, Alexander Ludwig, Bettina L. Serrallach, Bettina M. Zeidler, Sabrina Turker, Richard Parncutt, Annemarie Seither-Preisler
Auditory perception is fundamental to human development and communication. However, no long-term studies have been performed on the plasticity of the auditory system as a function of musical training from childhood to adulthood. The long-term interplay between developmental and training-induced neuroplasticity of auditory processing is still unknown. We present results from AMseL (Audio and Neuroplasticity
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Suppressive Control of Incentive Salience in Real-World Human Vision J. Neurosci. (IF 5.3) Pub Date : 2023-09-13 Clayton Hickey, David Acunzo, Jaclyn Dell
Reward-related activity in the dopaminergic midbrain is thought to guide animal behavior, in part by boosting the perceptual and attentional processing of reward-predictive environmental stimuli. In line with this incentive salience hypothesis, studies of human visual search have shown that simple synthetic stimuli, such as lines, shapes, or Gabor patches, capture attention to their location when they
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Evidence Accumulation Rate Moderates the Relationship between Enriched Environment Exposure and Age-Related Response Speed Declines J. Neurosci. (IF 5.3) Pub Date : 2023-09-13 Méadhbh Brosnan, Daniel J. Pearce, Megan H. O’Neill, Gerard M. Loughnane, Bryce Fleming, Shou-Han Zhou, Trevor Chong, Anna C. Nobre, Redmond G. O Connell, Mark A. Bellgrove
Older adults exposed to enriched environments (EEs) maintain relatively higher levels of cognitive function, even in the face of compromised markers of brain health. Response speed (RS) is often used as a simple proxy to measure the preservation of global cognitive function in older adults. However, it is unknown which specific selection, decision, and/or motor processes provide the most specific indices
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Hierarchical Modular Structure of the Drosophila Connectome J. Neurosci. (IF 5.3) Pub Date : 2023-09-13
The structure of neural circuitry plays a crucial role in brain function. Previous studies of brain organization generally had to trade off between coarse descriptions at a large scale and fine descriptions on a small scale. Researchers have now reconstructed tens to hundreds of thousands of neurons at synaptic resolution, enabling investigations into the interplay between global, modular organization
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Transient Oscillations of Neural Firing Rate Associated With Routing of Evidence in a Perceptual Decision J. Neurosci. (IF 5.3) Pub Date : 2023-09-13 Naomi N. Odean, Mehdi Sanayei, Michael N. Shadlen
To form a perceptual decision, the brain must acquire samples of evidence from the environment and incorporate them in computations that mediate choice behavior. While much is known about the neural circuits that process sensory information and those that form decisions, less is known about the mechanisms that establish the functional linkage between them. We trained monkeys of both sexes to make difficult
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Axon Initial Segment GABA Inhibits Action Potential Generation throughout Periadolescent Development J. Neurosci. (IF 5.3) Pub Date : 2023-09-13 Anna M. Lipkin, Kevin J. Bender
Neurons are remarkably polarized structures: dendrites spread and branch to receive synaptic inputs while a single axon extends and transmits action potentials (APs) to downstream targets. Neuronal polarity is maintained by the axon initial segment (AIS), a region between the soma and axon proper that is also the site of action potential (AP) generation. This polarization between dendrites and axons
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Why and How to Account for Sex and Gender in Brain and Behavioral Research J. Neurosci. (IF 5.3) Pub Date : 2023-09-13 Lise Eliot, Annaliese K. Beery, Emily G. Jacobs, Hannah F. LeBlanc, Donna L. Maney, Margaret M. McCarthy
Long overlooked in neuroscience research, sex and gender are increasingly included as key variables potentially impacting all levels of neurobehavioral analysis. Still, many neuroscientists do not understand the difference between the terms "sex" and "gender," the complexity and nuance of each, or how to best include them as variables in research designs. This TechSights article outlines rationales
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Reply to ‘When linguistic dogma rejects a neuroscientific hypothesis’ Nat. Rev. Neurosci. (IF 34.7) Pub Date : 2023-09-11 Nina Kazanina, Alessandro Tavano
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Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses Neuron (IF 16.2) Pub Date : 2023-09-13 Sean M. O’Toole, Hassana K. Oyibo, Georg B. Keller
Predictive processing postulates the existence of prediction error neurons in cortex. Neurons with both negative and positive prediction error response properties have been identified in layer 2/3 of visual cortex, but whether they correspond to transcriptionally defined subpopulations is unclear. Here we used the activity-dependent, photoconvertible marker CaMPARI2 to tag neurons in layer 2/3 of mouse
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TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions Brain (IF 14.5) Pub Date : 2023-09-13 Hashem Almousa, Sara A Lewis, Somayeh Bakhtiari, Sandra Hinz Nordlie, Alex Pagnozzi, Helen Magee, Stephanie Efthymiou, Jennifer A Heim, Patricia Cornejo, Maha S Zaki, Najwa Anwar, Shazia Maqbool, Fatima Rahman, Derek E Neilson, Anusha Vemuri, Sheng Chih Jin, Xiao-Ru Yang, Abolfazl Heidari, Koen van Gassen, Aurélien Trimouille, Christel Thauvin-Robinet, James Liu, Ange-Line Bruel, Hoda Tomoum, Mennatallah
Highly conserved transport protein particle (TRAPP) complexes regulate subcellular trafficking pathways. Accurate protein trafficking has been increasingly recognized to be critically important for normal development, particularly in the nervous system. Variants in most TRAPP complex subunits have been found to lead to neurodevelopmental disorders with diverse but overlapping phenotypes. We expand
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A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex Brain (IF 14.5) Pub Date : 2023-09-13 Andrea I Luppi, Manesh Girn, Fernando E Rosas, Christopher Timmermann, Leor Roseman, David Erritzoe, David J Nutt, Emmanuel A Stamatakis, R Nathan Spreng, Lei Xing, Wieland B Huttner, Robin L Carhart-Harris
Integrating independent but converging lines of research on brain function and neurodevelopment across scales, this article proposes that serotonin 2A receptor (5-HT2AR) signaling is an evolutionary and developmental driver and potent modulator of the macroscale functional organization of the human cerebral cortex. A wealth of evidence indicates that the anatomical and functional organization of the
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White matter tracts and executive functions: a review of causal and correlation evidence Brain (IF 14.5) Pub Date : 2023-09-13 Monica Ribeiro, Yordanka Nikolova Yordanova, Vincent Noblet, Guillaume Herbet, Damien Ricard
Executive functions are high-level cognitive processes involving abilities such as working memory/updating, set-shifting and inhibition. These complex cognitive functions are enabled by interactions among widely distributed cognitive networks, supported by white matter tracts. Executive impairment is frequent in neurological conditions affecting white matter; however, whether specific tracts are crucial
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Trazodone rescues dysregulated synaptic and mitochondrial nascent proteomes in prion neurodegeneration Brain (IF 14.5) Pub Date : 2023-09-13 Hector Albert-Gasco, Heather L Smith, Beatriz Alvarez-Castelao, Dean Swinden, Mark Halliday, Sudha Janaki-Raman, Adrian Butcher, Giovanna R Mallucci
The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target for protein misfolding neurodegenerative diseases, in which its overactivation results in sustained translational repression leading to synapse loss and neurodegeneration. In mouse models of these disorders, from Alzheimer’s to prion disease, modulation of the pathway - including by the licensed drug, trazodone
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Autosomal dominant in cis D4Z4 repeat array duplication alleles in facioscapulohumeral dystrophy Brain (IF 14.5) Pub Date : 2023-09-11 Richard J L F Lemmers, Russell Butterfield, Patrick J van der Vliet, Jan L de Bleecker, Ludo van der Pol, Diane M Dunn, Corrie E Erasmus, Marc D'Hooghe, Kristof Verhoeven, Judit Balog, Anne Bigot, Baziel van Engelen, Jeffrey Statland, Enrico Bugiardini, Nienke van der Stoep, Teresinha Evangelista, Chiara Marini-Bettolo, Peter van den Bergh, Rabi Tawil, Nicol C Voermans, John Vissing, Robert B Weiss
Facioscapulohumeral dystrophy (FSHD) has a unique genetic etiology resulting in partial chromatin relaxation of the D4Z4 macrosatellite repeat array on 4qter. This D4Z4 chromatin relaxation facilitates inappropriate expression of the transcription factor DUX4 in skeletal muscle. DUX4 is encoded by a retrogene which is embedded within the distal region of the D4Z4 repeat array. In the European population
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NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis Neuron (IF 16.2) Pub Date : 2023-09-07 Rui Zhan, Xia Meng, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Lemin Zheng
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Glial reactivity and T cell infiltration in frontotemporal lobar degeneration with tau pathology Brain (IF 14.5) Pub Date : 2023-09-10 Iain J Hartnell, Declan Woodhouse, William Jasper, Luke Mason, Pavan Marwaha, Manon Graffeuil, Laurie C Lau, Jeanette L Norman, David S Chatelet, Luc Buee, James A R Nicoll, David Blum, Guillaume Dorothee, Delphine Boche
Frontotemporal lobar degeneration with tau (FTLD-tau) is a group of tauopathies that underlie ∼50% of frontotemporal lobar degeneration (FTLD) cases. Identification of genetic risk variants related to innate/adaptive immunity have highlighted a role for neuroinflammation and neuroimmune interactions in FTLD. Studies have shown microglial and astrocyte activation together with T cell infiltration in
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Brain perivascular macrophages: current understanding and future prospects Brain (IF 14.5) Pub Date : 2023-09-09 Wenjie Wen, Jinping Cheng, Yamei Tang
Brain perivascular macrophages are specialized populations of macrophages that reside in the space around cerebral vessels, such as penetrating arteries and venules. With the help of cutting-edge technologies such as cell fate mapping and single-cell multi-omics, their multifaceted, pivotal roles in phagocytosis, antigen presentation, vascular integrity maintenance, and metabolic regulation have more
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Bidirectional synaptic changes in deep and superficial hippocampal neurons following in vivo activity Neuron (IF 16.2) Pub Date : 2023-09-08 Marcus Berndt, Massimo Trusel, Todd F. Roberts, Brad E. Pfeiffer, Lenora J. Volk
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Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling Neuron (IF 16.2) Pub Date : 2023-09-08 Eunhee Kim, Hyeonwoo Kim, Mark P. Jedrychowski, Grisilda Bakiasi, Joseph Park, Jane Kruskop, Younjung Choi, Sang Su Kwak, Luisa Quinti, Doo Yeon Kim, Christiane D. Wrann, Bruce M. Spiegelman, Rudolph E. Tanzi, Se Hoon Choi
A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β (Aβ) protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but the underlying mechanisms have not been elucidated. Irisin, an exercise-induced hormone, is the secreted form of fibronectin type-III-domain-containing 5 (FNDC5). Here, using a three-dimensional (3D) cell culture