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Hepatic soluble epoxide hydrolase: A promising target for unveiling the liver-brain axis in Alzheimer’s disease Neuron (IF 16.2) Pub Date : 2023-09-20 Yasuteru Inoue, Michael Bamkole, Takahisa Kanekiyo
Wu and Dong et al.1 report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-β (Aβ) deposits and cognitive impairment in mouse models for Alzheimer’s disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD.
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Functional architecture of dopamine neurons driving fear extinction learning Neuron (IF 16.2) Pub Date : 2023-09-22 Ximena I. Salinas-Hernández, Daphne Zafiri, Torfi Sigurdsson, Sevil Duvarci
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Accelerating scientific progress through Bayesian adversarial collaboration Neuron (IF 16.2) Pub Date : 2023-09-21 Andrew W. Corcoran, Jakob Hohwy, Karl J. Friston
Adversarial collaboration has been championed as the gold standard for resolving scientific disputes but has gained relatively limited traction in neuroscience and allied fields. In this perspective, we argue that adversarial collaborative research has been stymied by an overly restrictive concern with the falsification of scientific theories. We advocate instead for a more expansive view that frames
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Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis Neuron (IF 16.2) Pub Date : 2023-09-21 Svenja Bolz, Natalie Kaempf, Dmytro Puchkov, Michael Krauss, Giulia Russo, Tolga Soykan, Christopher Schmied, Martin Lehmann, Rainer Müller, Carsten Schultz, David Perrais, Tanja Maritzen, Volker Haucke
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Painspotting Neuron (IF 16.2) Pub Date : 2023-09-20 Donald Iain MacDonald, Alexander T. Chesler
How do we know an animal is feeling pain? In this issue of Neuron, Bohic et al.1 develop computational methods to detect pain in mice, shining a light on the behavioral changes that occur during pain, its relief, and recovery.
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Overcoming blood-brain barrier for targeted delivery of lysosome-targeting chimeras Neuron (IF 16.2) Pub Date : 2023-09-20 Qiang Cai, Quazi T.H. Shubhra
In a recent Chem article, Liu et al.1 introduced polydopamine-based lysosome-targeting chimeras (KPLYs). In in vitro cellular models, KPLYs adeptly cross the blood-brain barrier to target and eliminate β-amyloid aggregates. They also reduce inflammation and modulate microglial activity.
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A corticoamygdalar pathway controls reward devaluation and depression using dynamic inhibition code Neuron (IF 16.2) Pub Date : 2023-09-20 Zhengwei Yuan, Zhongyang Qi, Ruiyu Wang, Yuting Cui, Sile An, Guoli Wu, Qiru Feng, Rui Lin, Ruicheng Dai, Anan Li, Hui Gong, Qingming Luo, Ling Fu, Minmin Luo
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A cholinergic circuit that relieves pain despite opioid tolerance Neuron (IF 16.2) Pub Date : 2023-09-20 Shivang Sullere, Alissa Kunczt, Daniel S. McGehee
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Goal-seeking compresses neural codes for space in the human hippocampus and orbitofrontal cortex Neuron (IF 16.2) Pub Date : 2023-09-18 Paul S. Muhle-Karbe, Hannah Sheahan, Giovanni Pezzulo, Hugo J. Spiers, Samson Chien, Nicolas W. Schuck, Christopher Summerfield
Humans can navigate flexibly to meet their goals. Here, we asked how the neural representation of allocentric space is distorted by goal-directed behavior. Participants navigated an agent to two successive goal locations in a grid world environment comprising four interlinked rooms, with a contextual cue indicating the conditional dependence of one goal location on another. Examining the neural geometry
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Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch Neuron (IF 16.2) Pub Date : 2023-09-18 Annie Handler, Qiyu Zhang, Song Pang, Tri M. Nguyen, Michael Iskols, Michael Nolan-Tamariz, Stuart Cattel, Rebecca Plumb, Brianna Sanchez, Karyl Ashjian, Aria Shotland, Bartianna Brown, Madiha Kabeer, Josef Turecek, Michelle M. DeLisle, Genelle Rankin, Wangchu Xiang, Elisa C. Pavarino, Nusrat Africawala, Celine Santiago, David D. Ginty
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A view-based decision mechanism for rewards in the primate amygdala Neuron (IF 16.2) Pub Date : 2023-09-18 Fabian Grabenhorst, Adrián Ponce-Alvarez, Alexandra Battaglia-Mayer, Gustavo Deco, Wolfram Schultz
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Parkinson’s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons Neuron (IF 16.2) Pub Date : 2023-09-15 Pingping Song, Wesley Peng, Veronique Sauve, Rayan Fakih, Zhong Xie, Daniel Ysselstein, Talia Krainc, Yvette C. Wong, Niccolò E. Mencacci, Jeffrey N. Savas, D. James Surmeier, Kalle Gehring, Dimitri Krainc
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Molecularly targetable cell types in mouse visual cortex have distinguishable prediction error responses Neuron (IF 16.2) Pub Date : 2023-09-13 Sean M. O’Toole, Hassana K. Oyibo, Georg B. Keller
Predictive processing postulates the existence of prediction error neurons in cortex. Neurons with both negative and positive prediction error response properties have been identified in layer 2/3 of visual cortex, but whether they correspond to transcriptionally defined subpopulations is unclear. Here we used the activity-dependent, photoconvertible marker CaMPARI2 to tag neurons in layer 2/3 of mouse
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NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis Neuron (IF 16.2) Pub Date : 2023-09-07 Rui Zhan, Xia Meng, Dongping Tian, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Lemin Zheng
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Bidirectional synaptic changes in deep and superficial hippocampal neurons following in vivo activity Neuron (IF 16.2) Pub Date : 2023-09-08 Marcus Berndt, Massimo Trusel, Todd F. Roberts, Brad E. Pfeiffer, Lenora J. Volk
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Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling Neuron (IF 16.2) Pub Date : 2023-09-08 Eunhee Kim, Hyeonwoo Kim, Mark P. Jedrychowski, Grisilda Bakiasi, Joseph Park, Jane Kruskop, Younjung Choi, Sang Su Kwak, Luisa Quinti, Doo Yeon Kim, Christiane D. Wrann, Bruce M. Spiegelman, Rudolph E. Tanzi, Se Hoon Choi
A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β (Aβ) protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but the underlying mechanisms have not been elucidated. Irisin, an exercise-induced hormone, is the secreted form of fibronectin type-III-domain-containing 5 (FNDC5). Here, using a three-dimensional (3D) cell culture
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Reliable population code for subjective economic value from heterogeneous neuronal signals in primate orbitofrontal cortex Neuron (IF 16.2) Pub Date : 2023-09-06 Simone Ferrari-Toniolo, Wolfram Schultz
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NaV1.7: A central role in pain Neuron (IF 16.2) Pub Date : 2023-09-06 Stephen G. Waxman, Sulayman D. Dib-Hajj
Loss of function of sodium channel NaV1.7 produces pain insensitivity. In this issue, Deng et al.1 show that analgesia after NaV1.7 removal or pharmacological blockade is not driven by enkephalin overexpression. These results underscore the essential role, independent of endogenous opioids, of NaV1.7 for nociceptor firing and pain.
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A new way to mitigate pathological Tau? Neuron (IF 16.2) Pub Date : 2023-09-06 Asmita Ghosh, Christine Vande Velde
In this issue of Neuron, Wang et al.1 show that the RNA-binding protein G3BP2 interacts with Tau in human neurons and in brains of patients with Alzheimer’s disease (AD), suggesting a new role for G3BP2 with implications for therapeutic sequestration of Tau in neurodegenerative diseases.
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Locus of control: How the brain gives up when failure is taken for granted Neuron (IF 16.2) Pub Date : 2023-09-06 Joseph M. Villarin, Christoph Kellendonk
After repeatedly failing to get out of a stressful, uncontrollable environment, mice switch from escape behavior to inactivity. In this issue of Neuron, Li et al. identify a circuit involving noradrenergic projections from the locus coeruleus to GABAergic projection neurons in the orbitofrontal cortex that participate in this adaptive behavior.
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Structure and dynamics of differential ligand binding in the human ρ-type GABAA receptor Neuron (IF 16.2) Pub Date : 2023-09-01 John Cowgill, Chen Fan, Nandan Haloi, Victor Tobiasson, Yuxuan Zhuang, Rebecca J. Howard, Erik Lindahl
The neurotransmitter γ-aminobutyric acid (GABA) drives critical inhibitory processes in and beyond the nervous system, partly via ionotropic type-A receptors (GABAARs). Pharmacological properties of ρ-type GABAARs are particularly distinctive, yet the structural basis for their specialization remains unclear. Here, we present cryo-EM structures of a lipid-embedded human ρ1 GABAAR, including a partial
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Active cortical networks promote shunting fast synaptic inhibition in vivo Neuron (IF 16.2) Pub Date : 2023-09-01 Richard J. Burman, Paul J.N. Brodersen, Joseph V. Raimondo, Arjune Sen, Colin J. Akerman
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BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep Neuron (IF 16.2) Pub Date : 2023-08-31 Daniela Rojo, Louisa Dal Cengio, Anna Badner, Samuel Kim, Noriaki Sakai, Jacob Greene, Tess Dierckx, Lindsey C. Mehl, Ella Eisinger, Julia Ransom, Caroline Arellano-Garcia, Mohammad E. Gumma, Rebecca L. Soyk, Cheyanne M. Lewis, Mable Lam, Maya K. Weigel, Valentina Martinez Damonte, Belgin Yalçın, Samuel E. Jones, Hanna M. Ollila, Erin M. Gibson
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Differential cortical network engagement during states of un/consciousness in humans Neuron (IF 16.2) Pub Date : 2023-09-01 Rina Zelmann, Angelique C. Paulk, Fangyun Tian, Gustavo A. Balanza Villegas, Jaquelin Dezha Peralta, Britni Crocker, G. Rees Cosgrove, R. Mark Richardson, Ziv M. Williams, Darin D. Dougherty, Patrick L. Purdon, Sydney S. Cash
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Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice Neuron (IF 16.2) Pub Date : 2023-08-31 Zohreh Farsi, Ally Nicolella, Sean K. Simmons, Sameer Aryal, Nate Shepard, Kira Brenner, Sherry Lin, Linnea Herzog, Sean P. Moran, Katherine J. Stalnaker, Wangyong Shin, Vahid Gazestani, Bryan J. Song, Kevin Bonanno, Hasmik Keshishian, Steven A. Carr, Jen Q. Pan, Evan Z. Macosko, Sandeep Robert Datta, Borislav Dejanovic, Morgan Sheng
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Overlapping representations of food and social stimuli in mouse VTA dopamine neurons Neuron (IF 16.2) Pub Date : 2023-08-31 Lindsay Willmore, Adelaide R. Minerva, Ben Engelhard, Malavika Murugan, Brenna McMannon, Nirja Oak, Stephan Y. Thiberge, Catherine J. Peña, Ilana B. Witten
Dopamine neurons of the ventral tegmental area (VTADA) respond to food and social stimuli and contribute to both forms of motivation. However, it is unclear whether the same or different VTADA neurons encode these different stimuli. To address this question, we performed two-photon calcium imaging in mice presented with food and conspecifics and found statistically significant overlap in the populations
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Distinct circuits in anterior cingulate cortex encode safety assessment and mediate flexibility of fear reactions Neuron (IF 16.2) Pub Date : 2023-08-30 Kaibin Wu, Dijia Wang, Yuwei Wang, Peiwen Tang, Xuan Li, Yidi Pan, Huizhong W. Tao, Li I. Zhang, Feixue Liang
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Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration Neuron (IF 16.2) Pub Date : 2023-08-24 Hermany Munguba, Kasra Nikouei, Hannah Hochgerner, Polina Oberst, Alexandra Kouznetsova, Jesper Ryge, Ana Belén Muñoz-Manchado, Jennie Close, Renata Batista-Brito, Sten Linnarsson, Jens Hjerling-Leffler
Although cardinal cortical interneuron identity is established upon cell-cycle exit, it remains unclear whether specific interneuron subtypes are pre-established, and if so, how their identity is maintained prior to circuit integration. We conditionally removed Sox6 (Sox6-cKO) in migrating somatostatin (Sst+) interneurons and assessed the effects on their mature identity. In adolescent mice, five of
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Dual credit assignment processes underlie dopamine signals in a complex spatial environment Neuron (IF 16.2) Pub Date : 2023-08-22 Timothy A. Krausz, Alison E. Comrie, Ari E. Kahn, Loren M. Frank, Nathaniel D. Daw, Joshua D. Berke
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Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons Neuron (IF 16.2) Pub Date : 2023-08-22 Suresh K. Jetti, Andrés B. Crane, Yulia Akbergenova, Nicole A. Aponte-Santiago, Karen L. Cunningham, Charles A. Whittaker, J. Troy Littleton
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Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease Neuron (IF 16.2) Pub Date : 2023-08-18 Francesca Garretti, Connor Monahan, Nicholas Sloan, Jamie Bergen, Sanjid Shahriar, Seon Woo Kim, Alessandro Sette, Tyler Cutforth, Ellen Kanter, Dritan Agalliu, David Sulzer
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Spinocerebellar ataxia type 1: It’s not just about Purkinje cells Neuron (IF 16.2) Pub Date : 2023-08-16 Puneet Opal
In this issue of Neuron, Pilotto et al.1 use state-of-the-art in vivo imaging in mice to show that excitatory/inhibitory imbalance drives SCA1 pathophysiology, with hyperexcitable molecular layer interneurons overinhibiting Purkinje cells, leading to hallmark neurodegeneration.
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Fish who act on impulse must learn the consequences Neuron (IF 16.2) Pub Date : 2023-08-16 WenXi Zhou, David M. Schneider
Animals learn internal models that link specific behaviors to their anticipated sensory outcomes. In this issue of Neuron, Wallach and Sawtell1 discover that freely moving fish learn how the sensory outcome of a single behavior changes with local context.
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A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors Neuron (IF 16.2) Pub Date : 2023-08-16 Sami Boudkkazi, Jochen Schwenk, Naoki Nakaya, Aline Brechet, Astrid Kollewe, Harumi Harada, Wolfgang Bildl, Akos Kulik, Lijin Dong, Afia Sultana, Gerd Zolles, Uwe Schulte, Stanislav Tomarev, Bernd Fakler
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Temporally specific patterns of neural activity in interconnected corticolimbic structures during reward anticipation Neuron (IF 16.2) Pub Date : 2023-08-15 Megan E. Young, Camille Spencer-Salmon, Clayton Mosher, Sarita Tamang, Kanaka Rajan, Peter H. Rudebeck
Functional neuroimaging studies indicate that interconnected parts of the subcallosal anterior cingulate cortex (ACC), striatum, and amygdala play a fundamental role in affect in health and disease. Yet, although the patterns of neural activity engaged in the striatum and amygdala during affective processing are well established, especially during reward anticipation, less is known about subcallosal
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Neural dynamics in the limbic system during male social behaviors Neuron (IF 16.2) Pub Date : 2023-08-15 Zhichao Guo, Luping Yin, Veronica Diaz, Bing Dai, Takuya Osakada, Julieta E. Lischinsky, Jonathan Chien, Takashi Yamaguchi, Ashley Urtecho, Xiaoyu Tong, Zhe S. Chen, Dayu Lin
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Continuing trial responsibilities for implantable neural devices Neuron (IF 16.2) Pub Date : 2023-08-14 Saskia Hendriks, Nina Hsu, Andrea C. Beckel-Mitchener, John Ngai, Christine Grady
Participants of neural implant studies have research-related posttrial care needs (e.g., hardware replacements). Gaps in plans for posttrial care are currently common, which can have major consequences for patients. Professionals and organizations involved should address important unmet posttrial needs.
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A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan Neuron (IF 16.2) Pub Date : 2023-08-14 Wangchao Xu, Justin Rustenhoven, Christopher A. Nelson, Taitea Dykstra, Aura Ferreiro, Zachary Papadopoulos, Carey-Ann D. Burnham, Gautam Dantas, Daved H. Fremont, Jonathan Kipnis
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Biomechanical origins of proprioceptor feature selectivity and topographic maps in the Drosophila leg Neuron (IF 16.2) Pub Date : 2023-08-09 Akira Mamiya, Anne Sustar, Igor Siwanowicz, Yanyan Qi, Tzu-Chiao Lu, Pralaksha Gurung, Chenghao Chen, Jasper S. Phelps, Aaron T. Kuan, Alexandra Pacureanu, Wei-Chung Allen Lee, Hongjie Li, Natasha Mhatre, John C. Tuthill
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A common thalamic hub for general and defensive arousal control Neuron (IF 16.2) Pub Date : 2023-08-08 Yiwei Wang, Ling You, KaMun Tan, Meijie Li, Jingshan Zou, Zhifeng Zhao, Wenxin Hu, Tianyu Li, Fenghua Xie, Caiqin Li, Ruizhi Yuan, Kai Ding, Lingwei Cao, Fengyuan Xin, Congping Shang, Miaomiao Liu, Yixiao Gao, Liqiang Wei, Zhiwei You, Xiaorong Gao, Kexin Yuan
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Input-specific synaptic depression shapes temporal integration in mouse visual cortex Neuron (IF 16.2) Pub Date : 2023-08-04 Jennifer Y. Li, Lindsey L. Glickfeld
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TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels Neuron (IF 16.2) Pub Date : 2023-08-04 Wang Zheng, Shaun Rawson, Zhangfei Shen, Elakkiya Tamilselvan, Harper E. Smith, Julia Halford, Chen Shen, Swetha E. Murthy, Maximilian H. Ulbrich, Marcos Sotomayor, Tian-Min Fu, Jeffrey R. Holt
OSCA/TMEM63s form mechanically activated (MA) ion channels in plants and animals, respectively. OSCAs and related TMEM16s and transmembrane channel-like (TMC) proteins form homodimers with two pores. Here, we uncover an unanticipated monomeric configuration of TMEM63 proteins. Structures of TMEM63A and TMEM63B (referred to as TMEM63s) revealed a single highly restricted pore. Functional analyses demonstrated
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Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer’s disease Neuron (IF 16.2) Pub Date : 2023-08-04 Sofia Essayan-Perez, Thomas C. Südhof
Presenilin mutations that alter γ-secretase activity cause familial Alzheimer’s disease (AD), whereas ApoE4, an apolipoprotein for cholesterol transport, predisposes to sporadic AD. Both sporadic and familial AD feature synaptic dysfunction. Whether γ-secretase is involved in cholesterol metabolism and whether such involvement impacts synaptic function remains unknown. Here, we show that in human neurons
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Time and experience are independent determinants of representational drift in CA1 Neuron (IF 16.2) Pub Date : 2023-08-02 J. Quinn Lee, Mark P. Brandon
In this issue of Neuron, Khatib et al.1 and Geva et al.2 present complementary and breakthrough discoveries demonstrating that elapsed time and active experience independently affect unique aspects of representational drift in the hippocampus.
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Timing matters: A protective role of astrocyte reactivity in neurodegeneration Neuron (IF 16.2) Pub Date : 2023-08-02 Daniela Rojo, Erin M. Gibson
Sheehan and Nadarajah et al.1 identified that Bmal1 loss from astrocytes induces the expression of BAG3, a macroautophagy chaperone enriched in Alzheimer’s disease patients and in disease-associated astrocytes, enhancing the phagocytosis of misfolded proteins and preventing tau and alpha-synuclein pathologies.
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Jeffrey Watkins (1929–2023) Neuron (IF 16.2) Pub Date : 2023-08-02 Mark L. Mayer, Roger A. Nicoll
Abstract not available
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Rate versus synchrony codes for cerebellar control of motor behavior Neuron (IF 16.2) Pub Date : 2023-08-02 David J. Herzfeld, Mati Joshua, Stephen G. Lisberger
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Play and tickling responses map to the lateral columns of the rat periaqueductal gray Neuron (IF 16.2) Pub Date : 2023-07-28 Natalie Gloveli, Jean Simonnet, Wei Tang, Miguel Concha-Miranda, Eduard Maier, Anton Dvorzhak, Dietmar Schmitz, Michael Brecht
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Top-down control of exogenous attentional selection is mediated by beta coherence in prefrontal cortex Neuron (IF 16.2) Pub Date : 2023-07-26 Agrita Dubey, David A. Markowitz, Bijan Pesaran
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Dopamine release and negative valence gated by inhibitory neurons in the laterodorsal tegmental nucleus Neuron (IF 16.2) Pub Date : 2023-07-26 Yonglan Du, Siyao Zhou, Chenyan Ma, Hui Chen, Ana Du, Guochuang Deng, Yige Liu, Amanda J. Tose, Li Sun, Yijun Liu, Hangjun Wu, Huifang Lou, Yan-qin Yu, Ting Zhao, Stephan Lammel, Shumin Duan, Hongbin Yang
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PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke Neuron (IF 16.2) Pub Date : 2023-07-24 Akari Nakamura, Seiichiro Sakai, Yoshitaka Taketomi, Jun Tsuyama, Yoshimi Miki, Yuichiro Hara, Nobutaka Arai, Yuki Sugiura, Hideya Kawaji, Makoto Murakami, Takashi Shichita
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Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition Neuron (IF 16.2) Pub Date : 2023-07-21 Oliver J. Ziff, Jasmine Harley, Yiran Wang, Jacob Neeves, Giulia Tyzack, Fairouz Ibrahim, Mark Skehel, Anob M. Chakrabarti, Gavin Kelly, Rickie Patani
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A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction Neuron (IF 16.2) Pub Date : 2023-07-21 Ozge Gunduz-Cinar, Laura I. Castillo, Maya Xia, Elise Van Leer, Emma T. Brockway, Gabrielle A. Pollack, Farhana Yasmin, Olena Bukalo, Aaron Limoges, Sarvar Oreizi-Esfahani, Veronika Kondev, Rita Báldi, Ao Dong, Judy Harvey-White, Resat Cinar, George Kunos, Yulong Li, Larry S. Zweifel, Sachin Patel, Andrew Holmes
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Distinct spatial maps and multiple object codes in the lateral entorhinal cortex Neuron (IF 16.2) Pub Date : 2023-07-20
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Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome Neuron (IF 16.2) Pub Date : 2023-07-19
Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum disorder (ASD). However, the role of a major pathway controlling protein synthesis, the integrated stress response (ISR), in ASD remains poorly understood. Here, we demonstrate that the main arm of the ISR, eIF2α phosphorylation (p-eIF2α), is suppressed in excitatory, but not inhibitory, neurons in a mouse model
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Memory-related processing is the primary driver of human hippocampal theta oscillations Neuron (IF 16.2) Pub Date : 2023-07-18
Decades of work in rodents suggest that movement is a powerful driver of hippocampal low-frequency “theta” oscillations. Puzzlingly, such movement-related theta increases in primates are less sustained and of lower frequency, leading to questions about their functional relevance. Verbal memory encoding and retrieval lead to robust increases in low-frequency oscillations in humans, and one possibility
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Hippocampal GABAergic interneurons and memory Neuron (IF 16.2) Pub Date : 2023-07-18
One of the most captivating questions in neuroscience revolves around the brain’s ability to efficiently and durably capture and store information. It must process continuous input from sensory organs while also encoding memories that can persist throughout a lifetime. What are the cellular-, subcellular-, and network-level mechanisms that underlie this remarkable capacity for long-term information
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Clock cells ticking in summer Neuron (IF 16.2) Pub Date : 2023-07-19
In this issue of Neuron, Xie et al.1 highlight a role of cholecystokinin (CCK) neurons in the suprachiasmatic nucleus (SCN) central clock for tracking the onset of circadian activities, adapting circadian rhythms to long photoperiods, and regulating circadian phase resetting.
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Columnar and diffuse topographies in the marmoset prefrontal connectome Neuron (IF 16.2) Pub Date : 2023-07-19
In this issue of Neuron, Watakabe et al.1 utilize serial two-photon tomography to reveal that the intra- and inter-regional prefrontal cortex projections in the marmoset brain terminate with two characteristic patterns, columnar and diffused, both of which display a topographically organized gradient.
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