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A TBK1-independent primordial function of STING in lysosomal biogenesis Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Bo Lv, William A. Dion, Haoxiang Yang, Jinrui Xun, Do-Hyung Kim, Bokai Zhu, Jay Xiaojun Tan
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C2H2-zinc-finger transcription factors bind RNA and function in diverse post-transcriptional regulatory processes Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Syed Nabeel-Shah, Shuye Pu, James D. Burns, Ulrich Braunschweig, Nujhat Ahmed, Giovanni L. Burke, Hyunmin Lee, Ernest Radovani, Guoqing Zhong, Hua Tang, Edyta Marcon, Zhaolei Zhang, Timothy R. Hughes, Benjamin J. Blencowe, Jack F. Greenblatt
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Activation of automethylated PRC2 by dimerization on chromatin Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Paul V. Sauer, Egor Pavlenko, Trinity Cookis, Linda C. Zirden, Juliane Renn, Ankush Singhal, Pascal Hunold, Michaela N. Hoehne-Wiechmann, Olivia van Ray, Farnusch Kaschani, Markus Kaiser, Robert Hänsel-Hertsch, Karissa Y. Sanbonmatsu, Eva Nogales, Simon Poepsel
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Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Maya L. Gosztyla, Lijun Zhan, Sara Olson, Xintao Wei, Jack Naritomi, Grady Nguyen, Lena Street, Grant A. Goda, Francisco F. Cavazos, Jonathan C. Schmok, Manya Jain, Easin Uddin Syed, Eunjeong Kwon, Wenhao Jin, Eric Kofman, Alexandra T. Tankka, Allison Li, Valerie Gonzalez, Eric Lécuyer, Daniel Dominguez, Gene W. Yeo
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Large-scale map of RNA-binding protein interactomes across the mRNA life cycle Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Lena A. Street, Katherine L. Rothamel, Kristopher W. Brannan, Wenhao Jin, Benjamin J. Bokor, Kevin Dong, Kevin Rhine, Assael Madrigal, Norah Al-Azzam, Jenny Kim Kim, Yanzhe Ma, Darvesh Gorhe, Ahmed Abdou, Erica Wolin, Orel Mizrahi, Joshua Ahdout, Mayuresh Mujumdar, Ella Doron-Mandel, Marko Jovanovic, Gene W. Yeo
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Finish the unfinished: Chd1 resolving hexasome-nucleosome complex with FACT Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Hongxin Yin, Yang Liu
In this issue of Molecular Cell, Engeholm et al.1 present cryo-EM structures of the chromatin remodeler Chd1 bound to a hexasome-nucleosome complex, an intermediate state during transcription either with or without FACT to restore the missing H2A-H2B dimer. These two binding modes reveal how Chd1 and FACT cooperate in nucleosome re-establishment during transcription.
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Coming in out of the cold: Rho-dependent termination contributes to adaptation to cold shock Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Teppei Morita, Susan Gottesman
During cold shock, bacteria shut down translation of all but a set of cold-shock proteins critical for recovery; in this issue of Molecular Cell, Delaleau et al.1 show that Rho-dependent transcription termination plays an important role in cold adaptation, via temperature-regulated termination of the cold-shock protein mRNAs.
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Transcription regulation through selective partitioning: Weak interactions with a strong foundation Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Megan Palacio, Dylan J. Taatjes
In this issue of Molecular Cell, De La Cruz, Pradhan, Veettil et al.1 examine how selective partitioning of proteins via low-affinity IDR-dependent interactions may help regulate RNA polymerase II (RNA Pol II) function and identify sequence features that drive partitioning in cells.
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Ubiquitylation: Sword and shield in the bacterial arsenal Mol. Cell (IF 14.5) Pub Date : 2024-09-19 Jonathan N. Pruneda, Felix Randow
In two recent studies in Nature, Hör et al.1 and Chambers et al.2 report that ubiquitin-like conjugation in bacteria antagonizes phage replication.
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Spatial omics advances for in situ RNA biology Mol. Cell (IF 14.5) Pub Date : 2024-09-12 Jingyi Ren, Shuchen Luo, Hailing Shi, Xiao Wang
Spatial regulation of RNA plays a critical role in gene expression regulation and cellular function. Understanding spatially resolved RNA dynamics and translation is vital for bringing new insights into biological processes such as embryonic development, neurobiology, and disease pathology. This review explores past studies in subcellular, cellular, and tissue-level spatial RNA biology driven by diverse
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Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT Mol. Cell (IF 14.5) Pub Date : 2024-09-12 Maik Engeholm, Johann J. Roske, Elisa Oberbeckmann, Christian Dienemann, Michael Lidschreiber, Patrick Cramer, Lucas Farnung
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RAPIDASH: Tag-free enrichment of ribosome-associated proteins reveals composition dynamics in embryonic tissue, cancer cells, and macrophages Mol. Cell (IF 14.5) Pub Date : 2024-09-10 Teodorus Theo Susanto, Victoria Hung, Andrew G. Levine, Yuxiang Chen, Craig H. Kerr, Yongjin Yoo, Juan A. Oses-Prieto, Lisa Fromm, Zijian Zhang, Travis C. Lantz, Kotaro Fujii, Marius Wernig, Alma L. Burlingame, Davide Ruggero, Maria Barna
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Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity Mol. Cell (IF 14.5) Pub Date : 2024-09-09 Lang Bu, Huan Wang, Shuishen Zhang, Yi Zhang, Miaowen Liu, Zhengkun Zhang, Xueji Wu, Qiwei Jiang, Lei Wang, Wei Xie, Miao He, Zhengran Zhou, Chao Cheng, Jianping Guo
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Heterochromatin: Hiding from the remodeling machines Mol. Cell (IF 14.5) Pub Date : 2024-09-05 Craig L. Peterson
In this issue of Molecular Cell, Sahu et al.1 find that shielding heterochromatin from SWI/SNF chromatin remodelers is essential to maintain and epigenetically propagate pre-existing heterochromatin domains, whereas SWI/SNF action protects facultative heterochromatic regions from premature silencing.
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Proteasomes safeguard the plant stress granule homeostasis Mol. Cell (IF 14.5) Pub Date : 2024-09-05 Qi Chen, Xiaoxin Chen, Peiguo Yang
In this issue of Molecular Cell, Xie et al.1 revealed that the proteasome is a constitutive component of plant stress granules (SGs), and that enhanced proteolytic activity is essential for efficient SG disassembly and plant survival during the stress response.
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Anti-CRISPRs deconstruct bacterial defense Mol. Cell (IF 14.5) Pub Date : 2024-09-05 Nils Birkholz, Peter C. Fineran
Deploying anti-CRISPR proteins is a potent strategy used by phages to inhibit bacterial CRISPR-Cas defense. In a new Nature paper, Trost et al.1 discover and characterize an exciting anti-CRISPR mechanism with possible implications beyond this microscopic arms race.
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Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes Mol. Cell (IF 14.5) Pub Date : 2024-09-04 Rose Westhorpe, Johann J. Roske, Joseph T.P. Yeeles
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Disorder-mediated interactions target proteins to specific condensates Mol. Cell (IF 14.5) Pub Date : 2024-09-03 Nancy De La Cruz, Prashant Pradhan, Reshma T. Veettil, Brooke A. Conti, Mariano Oppikofer, Benjamin R. Sabari
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The high-light-sensitivity mechanism and optogenetic properties of the bacteriorhodopsin-like channelrhodopsin GtCCR4 Mol. Cell (IF 14.5) Pub Date : 2024-09-03 Tatsuki Tanaka, Shoko Hososhima, Yo Yamashita, Teppei Sugimoto, Toshiki Nakamura, Shunta Shigemura, Wataru Iida, Fumiya K. Sano, Kazumasa Oda, Takayuki Uchihashi, Kota Katayama, Yuji Furutani, Satoshi P. Tsunoda, Wataru Shihoya, Hideki Kandori, Osamu Nureki
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PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation Mol. Cell (IF 14.5) Pub Date : 2024-09-03 Zhenwei Liang, Tao Zhu, Yaoguang Yu, Caihong Wu, Yisui Huang, Yuanhao Hao, Xin Song, Wei Fu, Liangbing Yuan, Yuhai Cui, Shangzhi Huang, Chenlong Li
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Stabilization of the hexasome intermediate during histone exchange by yeast SWR1 complex Mol. Cell (IF 14.5) Pub Date : 2024-09-02 Adam S.B. Jalal, Paul Girvan, Eugene Y.D. Chua, Lexin Liu, Shijie Wang, Elizabeth A. McCormack, Michael T. Skehan, Carol L. Knight, David S. Rueda, Dale B. Wigley
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Genome access is transcription factor-specific and defined by nucleosome position Mol. Cell (IF 14.5) Pub Date : 2024-08-28 Ralph Stefan Grand, Marco Pregnolato, Lisa Baumgartner, Leslie Hoerner, Lukas Burger, Dirk Schübeler
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RNA polymerases reshape chromatin architecture and couple transcription on individual fibers Mol. Cell (IF 14.5) Pub Date : 2024-08-26 Thomas W. Tullius, R. Stefan Isaac, Danilo Dubocanin, Jane Ranchalis, L. Stirling Churchman, Andrew B. Stergachis
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Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Nirmalya Dasgupta, Xue Lei, Christina Huan Shi, Rouven Arnold, Marcos G. Teneche, Karl N. Miller, Adarsh Rajesh, Andrew Davis, Valesca Anschau, Alexandre R. Campos, Rebecca Gilson, Aaron Havas, Shanshan Yin, Zong Ming Chua, Tianhui Liu, Jessica Proulx, Michael Alcaraz, Mohammed Iqbal Rather, Josue Baeza, David C. Schultz, Peter D. Adams
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Rho-dependent transcriptional switches regulate the bacterial response to cold shock Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Mildred Delaleau, Nara Figueroa-Bossi, Thuy Duong Do, Patricia Kerboriou, Eric Eveno, Lionello Bossi, Marc Boudvillain
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Mechanism of homology search expansion during recombinational DNA break repair in Saccharomyces cerevisiae Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Agnès Dumont, Nicolas Mendiboure, Jérôme Savocco, Loqmen Anani, Pierrick Moreau, Agnès Thierry, Laurent Modolo, Daniel Jost, Aurèle Piazza
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Navigating the complexity of Polycomb repression: Enzymatic cores and regulatory modules Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Simone Tamburri, Samantha Rustichelli, Simona Amato, Diego Pasini
Polycomb proteins are a fundamental repressive system that plays crucial developmental roles by orchestrating cell-type-specific transcription programs that govern cell identity. Direct alterations of Polycomb activity are indeed implicated in human pathologies, including developmental disorders and cancer. General Polycomb repression is coordinated by three distinct activities that regulate the deposition
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A FACT about macroH2A removal in immune gene activation Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Oliver Meers, Marcus Buschbeck
Histone variants contribute to epigenetic regulation in development and disease but require the chaperone machinery for correct deposition. In this issue of Molecular Cell, Ji et al.1 explain how the chaperone complex FACT removes the histone variant macroH2A1.2 and demonstrate its importance for gene activation in innate immune cells.
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Ubiquitin gets sweet: Sugar-mediated ubiquitination regulates Nrf1 function Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Alison C. Mody, Christina M. Woo
In this issue of Molecular Cell, Yoshida et al.1 report an unconventional sugar-dependent ubiquitination event on Nrf1 that disrupts Nrf1 transcriptional activation.
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An intrinsically disordered region in MED13 turns Mediator on/off on cue Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Vincent Villeret, Didier Monté, Alexis Verger
Complementary studies by Zhao et al.1 and Chen et al.2 reveal how an intrinsically disordered region in MED13 controls mutually exclusive binding of RNA Polymerase II and CDK8 kinase module to Mediator, switching Mediator and transcription activation on and off.
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snoRNAs in making “snoman” ribosomes Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Adrianna Dabrowska, Davide Ruggero
In a recent study in Cell, Cheng and Wang et al.1 show that the small nucleolar RNA (snoRNA) SNORA13 has a non-canonical role in ribosome biogenesis and senescence by acting directly on RPL23 and regulating its assembly into the 60S ribosomal subunit.
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RAD51 protects abasic sites to prevent replication fork breakage Mol. Cell (IF 14.5) Pub Date : 2024-08-22 Yodhara Wijesekara Hanthi, Miguel Angel Ramirez-Otero, Robert Appleby, Anna De Antoni, Luay Joudeh, Vincenzo Sannino, Salli Waked, Alessandra Ardizzoia, Viviana Barra, Daniele Fachinetti, Luca Pellegrini, Vincenzo Costanzo
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Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins Mol. Cell (IF 14.5) Pub Date : 2024-08-21 Katharine R. Page, Vy N. Nguyen, Tino Pleiner, Giovani Pinton Tomaleri, Maxine L. Wang, Alina Guna, Masami Hazu, Ting-Yu Wang, Tsui-Fen Chou, Rebecca M. Voorhees
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RNA interacts with topoisomerase I to adjust DNA topology Mol. Cell (IF 14.5) Pub Date : 2024-08-21 Mannan Bhola, Kouki Abe, Paola Orozco, Homa Rahnamoun, Pedro Avila-Lopez, Elijah Taylor, Nefertiti Muhammad, Bei Liu, Prachi Patel, John F. Marko, Anne C. Starner, Chuan He, Eric L. Van Nostrand, Alfonso Mondragón, Shannon M. Lauberth
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Proteasome resides in and dismantles plant heat stress granules constitutively Mol. Cell (IF 14.5) Pub Date : 2024-08-21 Zhouli Xie, Shuai Zhao, Yuchen Tu, Enhui Liu, Ying Li, Xingwei Wang, Changtian Chen, Shuwei Zhai, Jie Qi, Chengyun Wu, Honghong Wu, Mian Zhou, Wei Wang
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Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries Mol. Cell (IF 14.5) Pub Date : 2024-08-21 Havva Ortabozkoyun, Pin-Yao Huang, Edgar Gonzalez-Buendia, Hyein Cho, Sang Y. Kim, Aristotelis Tsirigos, Esteban O. Mazzoni, Danny Reinberg
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Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activation Mol. Cell (IF 14.5) Pub Date : 2024-08-21 Li Nie, Chenjie Fei, Yizeng Fan, Fabin Dang, Ziyue Zhao, Tingfang Zhu, Xiangyu Wu, Ting Dai, Arumugam Balasubramanian, Jing Pan, Yang Hu, Hongbo R. Luo, Wenyi Wei, Jiong Chen
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Nuclear PKM2 binds pre-mRNA at folded G-quadruplexes and reveals their gene regulatory role Mol. Cell (IF 14.5) Pub Date : 2024-08-16
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A liquid-like coat mediates chromosome clustering during mitotic exit Mol. Cell (IF 14.5) Pub Date : 2024-08-16 Alberto Hernandez-Armendariz, Valerio Sorichetti, Yuki Hayashi, Zuzana Koskova, Andreas Brunner, Jan Ellenberg, Anđela Šarić, Sara Cuylen-Haering
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Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells Mol. Cell (IF 14.5) Pub Date : 2024-08-15 Zhenxi Zhang, Yanting Yang, Yang Chen, Jingyu Su, Wenjing Du
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Molecular impact of mutations in RNA splicing factors in cancer Mol. Cell (IF 14.5) Pub Date : 2024-08-14
Somatic mutations in genes encoding components of the RNA splicing machinery occur frequently in multiple forms of cancer. The most frequently mutated RNA splicing factors in cancer impact intronic branch site and 3′ splice site recognition. These include mutations in the core RNA splicing factor SF3B1 as well as mutations in the U2AF1/2 heterodimeric complex, which recruits the SF3b complex to the
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Functional and structural insights into RAS effector proteins Mol. Cell (IF 14.5) Pub Date : 2024-08-13 Alessandro M. Mozzarelli, Dhirendra K. Simanshu, Pau Castel
No Abstract
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OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response Mol. Cell (IF 14.5) Pub Date : 2024-08-13 Felix G. Liang, Fereshteh Zandkarimi, Jaehoon Lee, Joshua L. Axelrod, Ryan Pekson, Yisang Yoon, Brent R. Stockwell, Richard N. Kitsis
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HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability Mol. Cell (IF 14.5) Pub Date : 2024-08-13 Gongshi Bai, Theresa Endres, Ulrike Kühbacher, Valentina Mengoli, Briana H. Greer, Emma M. Peacock, Matthew D. Newton, Tyler Stanage, Maria Rosaria Dello Stritto, Roxana Lungu, Magdalena P. Crossley, Ataya Sathirachinda, David Cortez, Simon J. Boulton, Petr Cejka, Brandt F. Eichman, Karlene A. Cimprich
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Nuclear retention coupled with sequential polyadenylation dictates post-transcriptional m6A modification in the nucleus Mol. Cell (IF 14.5) Pub Date : 2024-08-09
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Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4 Mol. Cell (IF 14.5) Pub Date : 2024-08-08 Bing-Rui Zhou, Hanqiao Feng, Furong Huang, Iris Zhu, Stephanie Portillo-Ledesma, Dan Shi, Kenneth S. Zaret, Tamar Schlick, David Landsman, Qianben Wang, Yawen Bai
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Meet the authors: Emily R. Feierman and Erica Korb Mol. Cell (IF 14.5) Pub Date : 2024-08-08 Emily R. Feierman, Erica Korb
We talk to first author Emily R. Feierman and corresponding author Erica Korb about the journey toward their paper “Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory” (this issue of Molecular Cell) and changes smoothing the road for women in science.
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Puff, the polytene chromosome: Visualizing transcription elongation control Mol. Cell (IF 14.5) Pub Date : 2024-08-08 Mo Chen
In this issue, Versluis et al.1 use a highly sensitive live-cell imaging system to examine transcription dynamics and functions of various key transcription elongation regulators at the Hsp70 loci.
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Two HUSH complexes connect a direct LINE to innate immunity Mol. Cell (IF 14.5) Pub Date : 2024-08-08 Geoffrey J. Faulkner
In this issue of Molecular Cell, Danac et al.1 identify a second HUSH complex, HUSH2, that represses interferon-stimulated genes and, by competing for subunits with the canonical HUSH complex, couples LINE-1 (L1) retrotransposon transcription with immune activation.
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Decoding the end of message: PASTA provides food for thought on mechanisms of alternative polyadenylation Mol. Cell (IF 14.5) Pub Date : 2024-08-08 Bin Tian
In a recent publication in Cell, Kowalski et al.1 developed an interdisciplinary and multiplexed approach to uncover regulatory modules of alternative polyadenylation, involving single-cell-based gene perturbation, isoform abundance analysis, machine learning of RNA motifs, and massively parallel reporter assays.
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Live-cell imaging of RNA Pol II and elongation factors distinguishes competing mechanisms of transcription regulation Mol. Cell (IF 14.5) Pub Date : 2024-08-08 Philip Versluis, Thomas G.W. Graham, Vincent Eng, Jonathan Ebenezer, Xavier Darzacq, Warren R. Zipfel, John T. Lis
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FACT mediates the depletion of macroH2A1.2 to expedite gene transcription Mol. Cell (IF 14.5) Pub Date : 2024-08-07 Dengyu Ji, Xue Xiao, Anfeng Luo, Xiongxiong Fan, Jingzhe Ma, Dayi Wang, Miaoran Xia, Lu Ma, Peng-Ye Wang, Wei Li, Ping Chen
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A Genome-Wide Analysis Indicates that Yeast Pre-mRNA Splicing Is Predominantly Posttranscriptional Mol. Cell (IF 14.5) Pub Date : 2024-08-07 Daniel F. Tardiff, Scott A. Lacadie, Michael Rosbash
No Abstract
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Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation Mol. Cell (IF 14.5) Pub Date : 2024-08-07 Yukiko Yoshida, Tsuyoshi Takahashi, Nozomi Ishii, Ichiro Matsuo, Satoshi Takahashi, Haruka Inoue, Akinori Endo, Hikaru Tsuchiya, Meari Okada, Chikara Ando, Takehiro Suzuki, Naoshi Dohmae, Yasushi Saeki, Keiji Tanaka, Tadashi Suzuki
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Structural determinants of DNA cleavage by a CRISPR HNH-Cascade system Mol. Cell (IF 14.5) Pub Date : 2024-08-06 Seiichi Hirano, Han Altae-Tran, Soumya Kannan, Rhiannon K. Macrae, Feng Zhang
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A ligation-independent sequencing method reveals tRNA-derived RNAs with blocked 3′ termini Mol. Cell (IF 14.5) Pub Date : 2024-08-02
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Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos Mol. Cell (IF 14.5) Pub Date : 2024-08-02 Niannian Xue, Dishan Hong, Dan Zhang, Qian Wang, Shun Zhang, Lei Yang, Xi Chen, Yongmei Li, Honghui Han, Chunyi Hu, Mingyao Liu, Gaojie Song, Yuting Guan, Liren Wang, Yifan Zhu, Dali Li
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Nucleosome remodeler exclusion by histone deacetylation enforces heterochromatic silencing and epigenetic inheritance Mol. Cell (IF 14.5) Pub Date : 2024-08-02 Rakesh Kumar Sahu, Jothy Dhakshnamoorthy, Shweta Jain, Hernan Diego Folco, David Wheeler, Shiv I.S. Grewal
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Mrc1 regulates parental histone segregation and heterochromatin inheritance Mol. Cell (IF 14.5) Pub Date : 2024-08-01 Takenori Toda, Yimeng Fang, Chun-Min Shan, Xu Hua, Jin-Kwang Kim, Lauren Clarissa Tang, Marko Jovanovic, Liang Tong, Feng Qiao, Zhiguo Zhang, Songtao Jia
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The V-ATPase/ATG16L1 axis is controlled by the V1H subunit Mol. Cell (IF 14.5) Pub Date : 2024-07-31 Lewis Timimi, Antoni G. Wrobel, George N. Chiduza, Sarah L. Maslen, Antonio Torres-Méndez, Beatriz Montaner, Colin Davis, Taylor Minckley, Katriona L. Hole, Andrea Serio, Michael J. Devine, J. Mark Skehel, John L. Rubinstein, Anne Schreiber, Rupert Beale