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Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1 Mol. Cell (IF 17.97) Pub Date : 2022-06-24 Samuel A. Killackey, Yuntian Bi, Fraser Soares, Ikram Hammi, Nathaniel J. Winsor, Ali A. Abdul-Sater, Dana J. Philpott, Damien Arnoult, Stephen E. Girardin
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Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles Mol. Cell (IF 17.97) Pub Date : 2022-06-24 Nicholas W. Hughes, Yuanhao Qu, Jiaqi Zhang, Weijing Tang, Justin Pierce, Chengkun Wang, Aditi Agrawal, Maurizio Morri, Norma Neff, Monte M. Winslow, Mengdi Wang, Le Cong
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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis Mol. Cell (IF 17.97) Pub Date : 2022-06-24 Dan He, Huijin Feng, Belen Sundberg, Jiaxing Yang, Justin Powers, Alec H. Christian, John E. Wilkinson, Cian Monnin, Daina Avizonis, Craig J. Thomas, Richard A. Friedman, Michael D. Kluger, Michael A. Hollingsworth, Paul M. Grandgenett, Kelsey A. Klute, F. Dean Toste, Christopher J. Chang, Iok In Christine Chio
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TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells Mol. Cell (IF 17.97) Pub Date : 2022-06-22 Huafeng Zhang, Jincheng Liu, Zhuoshun Yang, Liping Zeng, Keke Wei, Liyan Zhu, Liang Tang, Dianheng Wang, Yabo Zhou, Jiadi Lv, Nannan Zhou, Ke Tang, Jingwei Ma, Bo Huang
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Supramolecular assembly of GSK3α as a cellular response to amino acid starvation Mol. Cell (IF 17.97) Pub Date : 2022-06-21 Laura Hinze, Sabine Schreek, Andre Zeug, Nurul Khalida Ibrahim, Beate Fehlhaber, Lorent Loxha, Buesra Cinar, Evgeni Ponimaskin, James Degar, Connor McGuckin, Gabriela Chiosis, Cornelia Eckert, Gunnar Cario, Beat Bornhauser, Jean-Pierre Bourquin, Martin Stanulla, Alejandro Gutierrez
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Integration of light and temperature sensing by liquid-liquid phase separation of phytochrome B Mol. Cell (IF 17.97) Pub Date : 2022-06-20 Di Chen, Mohan Lyu, Xiaoxia Kou, Jing Li, Zhixuan Yang, Lulu Gao, Yue Li, Liu-min Fan, Hui Shi, Shangwei Zhong
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Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas Mol. Cell (IF 17.97) Pub Date : 2022-06-17 Nofar Harpaz, Tamir Mittelman, Olga Beresh, Ofir Griess, Noa Furth, Tomer-Meir Salame, Roni Oren, Liat Fellus-Alyagor, Alon Harmelin, Sanda Alexandrescu, Joana Graca Marques, Mariella G. Filbin, Guy Ron, Efrat Shema
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Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Gokhan Unlu, Benjamin Prizer, Ranya Erdal, Hsi-Wen Yeh, Erol C. Bayraktar, Kıvanç Birsoy
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GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Sijie Huang, Peiyu Xu, Dan-Dan Shen, Icaro A. Simon, Chunyou Mao, Yangxia Tan, Huibing Zhang, Kasper Harpsøe, Huadong Li, Yumu Zhang, Chongzhao You, Xuekui Yu, Yi Jiang, Yan Zhang, David E. Gloriam, H. Eric Xu
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25 years of molecular mechanisms Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Brian Plosky
Abstract not available
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Diving into chromatin organization and DNA repair: An interview with Dr. Susan M. Gasser Mol. Cell (IF 17.97) Pub Date : 2022-06-16
For our 25th anniversary issue of Molecular Cell, we talk to one of our original board members, Dr. Susan M. Gasser, on the trajectory of her research in chromatin response to DNA repair, the concepts in the field, and technologies that influenced these discoveries. She also shares her thoughts on the evolution of Molecular Cell and what makes a “good” paper.
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Transcriptional regulation and exploring uncharted waters: An interview with Dr. James T. Kadonaga Mol. Cell (IF 17.97) Pub Date : 2022-06-16
For our 25th anniversary of Molecular Cell, we talk to one of our original board members, Dr. James T. Kadonaga, about the trajectory of his research in transcriptional regulation and chromatin dynamics and the complexity of gene regulation. He also shares anecdotes from the early days of Molecular Cell, what makes a compelling paper, and advice for junior scientists.
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Chaperonins, collaborations, and challenging dogmas: An interview with Dr. Arthur L. Horwich Mol. Cell (IF 17.97) Pub Date : 2022-06-16
For our 25th anniversary of Molecular Cell, we talk to one of our original board members, Dr. Arthur L. Horwich, about the discovery of chaperones, the importance of challenging “dogmas,” and the benefits of scientific collaboration. He also shares anecdotes from the early days of Molecular Cell, some of his favorite papers, and his advice for junior scientists.
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The promises and pitfalls of specialized ribosomes Mol. Cell (IF 17.97) Pub Date : 2022-06-16
The concept of specialized ribosomes has garnered equal amounts of interest and skepticism since it was first introduced. We ask researchers in the field to provide their perspective on the topic and weigh in on the evidence (or lack thereof) and what the future may bring.
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Turning down the (C)BASS: Phage-encoded inhibitors jam bacterial immune signaling Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Nils Birkholz, Peter C. Fineran
Where there is defense, there is counter-defense. A paper by Hobbs et al. (2022) reconfirms that this emerging tenet of the arms race between bacteria and their predators also holds true for phage defense systems that rely on secondary messenger signals.
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TADs do not stay in the loop Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Davide Michieletto, Wendy A. Bickmore
In a recent issue of Science, Gabriele et al. have, for the first time, quantified the dynamics of a topologically associating domain (TAD) in live cells by coupling super-resolution imaging and computational modelling, concluding that a TAD spends most of its life in a “partially extruded state” and that CTCF-CTCF loops are rare.
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Beyond rare disorders: A new era for peroxisomal pathophysiology Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Einat Zalckvar, Maya Schuldiner
Metabolism is emerging as a central influencer of multiple disease states in humans. Peroxisomes are central metabolic organelles whose decreased function gives rise to severe peroxisomal diseases. Recently, it is becoming clear that, beyond such rare inborn errors, the deterioration of peroxisomal functions contributes to multiple and prevalent diseases such as cancer, viral infection, diabetes, and
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Hidden codes in mRNA: Control of gene expression by m6A Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Shino Murakami, Samie R. Jaffrey
Information in mRNA has largely been thought to be confined to its nucleotide sequence. However, the advent of mapping techniques to detect modified nucleotides has revealed that mRNA contains additional information in the form of chemical modifications. The most abundant modified nucleotide is N6-methyladenosine (m6A), a methyl modification of adenosine. Although early studies viewed m6A as a dynamic
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Integrated lncRNA function upon genomic and epigenomic regulation Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Allison B. Herman, Dimitrios Tsitsipatis, Myriam Gorospe
Although some long noncoding (lnc)RNAs are known since the 1950s, the past 25 years have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The advent of high-throughput and sensitive technologies has further uncovered the vast heterogeneity of lncRNA-interacting molecules and patterns of expressed lncRNAs. We propose a unifying functional theme for the expansive family of
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Hallmarks of DNA replication stress Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Sneha Saxena, Lee Zou
Faithful DNA replication is critical for the maintenance of genomic integrity. Although DNA replication machinery is highly accurate, the process of DNA replication is constantly challenged by DNA damage and other intrinsic and extrinsic stresses throughout the genome. A variety of cellular stresses interfering with DNA replication, which are collectively termed replication stress, pose a threat to
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Unbiased spatial proteomics with single-cell resolution in tissues Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Andreas Mund, Andreas-David Brunner, Matthias Mann
Mass spectrometry (MS)-based proteomics has become a powerful technology to quantify the entire complement of proteins in cells or tissues. Here, we review challenges and recent advances in the LC-MS-based analysis of minute protein amounts, down to the level of single cells. Application of this technology revealed that single-cell transcriptomes are dominated by stochastic noise due to the very low
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SnapShot: Chromosome organization Mol. Cell (IF 17.97) Pub Date : 2022-06-16 Rachel Patton McCord, Yang Xu, Heng Li, Priyojit Das, Rebeca San Martin
Chromosomes in higher eukaryotes are folded at different length scales into loop extrusion domains, spatial compartments, and chromosome territories and exhibit interactions with nuclear structures such as the lamina. Microscopic methods can probe this structure by measuring positions of chromosomes in the nuclear space in individual cells, while sequencing-based contact capture approaches can report
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Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation Mol. Cell (IF 17.97) Pub Date : 2022-06-15 Ina Huppertz, Joel I. Perez-Perri, Panagiotis Mantas, Thileepan Sekaran, Thomas Schwarzl, Francesco Russo, Dunja Ferring-Appel, Zuzana Koskova, Lyudmila Dimitrova-Paternoga, Eleni Kafkia, Janosch Hennig, Pierre A. Neveu, Kiran Patil, Matthias W. Hentze
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Mechanism of exon ligation by human spliceosome Mol. Cell (IF 17.97) Pub Date : 2022-06-14 Xiechao Zhan, Yichen Lu, Xiaofeng Zhang, Chuangye Yan, Yigong Shi
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Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome Mol. Cell (IF 17.97) Pub Date : 2022-06-09 Piotr Gerlach, William Garland, Mahesh Lingaraju, Anna Salerno-Kochan, Fabien Bonneau, Jérôme Basquin, Torben Heick Jensen, Elena Conti
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Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine Mol. Cell (IF 17.97) Pub Date : 2022-06-08 Daniel Arango, David Sturgill, Renbin Yang, Tapan Kanai, Paulina Bauer, Jyoti Roy, Ziqiu Wang, Masaki Hosogane, Sarah Schiffers, Shalini Oberdoerffer
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AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay Mol. Cell (IF 17.97) Pub Date : 2022-06-07 Hana Cho, Elizabeth T. Abshire, Maximilian W. Popp, Christoph Pröschel, Joshua L. Schwartz, Gene W. Yeo, Lynne E. Maquat
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A conceptual framework for understanding phase separation and addressing open questions and challenges Mol. Cell (IF 17.97) Pub Date : 2022-06-07 Tanja Mittag, Rohit V. Pappu
Macromolecular phase separation is being recognized for its potential importance and relevance as a driver of spatial organization within cells. Here, we describe a framework based on synergies between networking (percolation or gelation) and density (phase separation) transitions. Accordingly, the phase transitions in question are referred to as phase separation coupled to percolation (PSCP). The
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Itaconate is a lysosomal inducer that promotes antibacterial innate immunity Mol. Cell (IF 17.97) Pub Date : 2022-06-03 Zhenxing Zhang, Chao Chen, Fan Yang, Yi-Xin Zeng, Pengkai Sun, Ping Liu, Xinjian Li
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Stressful steps: Progress and challenges in understanding stress-induced mRNA condensation and accumulation in stress granules Mol. Cell (IF 17.97) Pub Date : 2022-06-03 Hendrik Glauninger, Caitlin J. Wong Hickernell, Jared A.M. Bard, D. Allan Drummond
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Coenzyme A precursors flow from mother to zygote and from microbiome to host Mol. Cell (IF 17.97) Pub Date : 2022-06-03 Yi Yu, Marianne van der Zwaag, Jouke Jan Wedman, Hjalmar Permentier, Niels Plomp, Xiu Jia, Bart Kanon, Ellie Eggens-Meijer, Girbe Buist, Hermie Harmsen, Jan Kok, Joana Falcao Salles, Bregje Wertheim, Susan J. Hayflick, Erick Strauss, Nicola A. Grzeschik, Hein Schepers, Ody C.M. Sibon
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Condensates induced by transcription inhibition localize active chromatin to nucleoli Mol. Cell (IF 17.97) Pub Date : 2022-06-02 Takaaki Yasuhara, Yu-Hang Xing, Nicholas C. Bauer, Lukuo Lee, Rui Dong, Tribhuwan Yadav, Roy J. Soberman, Miguel N. Rivera, Lee Zou
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Structural basis of transposon end recognition explains central features of Tn7 transposition systems Mol. Cell (IF 17.97) Pub Date : 2022-06-01 Zuzanna Kaczmarska, Mariusz Czarnocki-Cieciura, Karolina M. Górecka-Minakowska, Robert J. Wingo, Justyna Jackiewicz, Weronika Zajko, Jarosław T. Poznański, Michał Rawski, Timothy Grant, Joseph E. Peters, Marcin Nowotny
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A pro-metastatic tRNA fragment drives Nucleolin oligomerization and stabilization of its bound metabolic mRNAs Mol. Cell (IF 17.97) Pub Date : 2022-06-01 Xuhang Liu, Wenbin Mei, Veena Padmanaban, Hanan Alwaseem, Henrik Molina, Maria C. Passarelli, Bernardo Tavora, Sohail F. Tavazoie
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Anti-CRISPR prediction using deep learning reveals an inhibitor of Cas13b nucleases Mol. Cell (IF 17.97) Pub Date : 2022-05-31 Katharina G. Wandera, Omer S. Alkhnbashi, Harris v.I. Bassett, Alexander Mitrofanov, Sven Hauns, Anzhela Migur, Rolf Backofen, Chase L. Beisel
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Meet the authors: Laura Hsieh, Muryam Gourdet, and Geeta Narlikar Mol. Cell (IF 17.97) Pub Date : 2022-06-02
We talk to co-first authors Laura Hsieh and Muryam Gourdet, and professor Geeta Narlikar, about their academic journeys, juggling motherhood and lab work during the pandemic, their paper, “A hexasome is the preferred substrate for the INO80 chromatin remodeling complex, allowing versatility of function,” and the importance of remaining open-minded and unafraid to challenge the field.
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Regulating gene expression through control of transcription factor multivalent interactions Mol. Cell (IF 17.97) Pub Date : 2022-06-02 Benjamin T. Donovan, Daniel R. Larson
Chong et al. (2022) show how the propensity of transcription factors (TFs) to associate into hubs must be finely regulated for optimal transcription.
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Something’s gotta give at the centromeric chromatin foundation of the kinetochore Mol. Cell (IF 17.97) Pub Date : 2022-06-02 Kathryn Kixmoeller, Praveen Kumar Allu, Ben E. Black
Structures of the reconstituted human inner kinetochore complex by Pesenti et al. (2022) and Yatskevich et al. (2022) raise the question of whether it is the CENP-A nucleosome or the CCAN complex itself that provides the foundation for kinetochore assembly.
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Poly(m6A) tails stabilize transcripts Mol. Cell (IF 17.97) Pub Date : 2022-06-02 Guillaume Lavergne, Jean-Yves Roignant
Viegas et al. (2022) discover that in Trypanosoma brucei the poly(A) tails of the variant surface glycoprotein (VSG) transcripts are methylated, a mechanism that stabilizes these transcripts and ensures protection against the immune response in mammals.
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A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression Mol. Cell (IF 17.97) Pub Date : 2022-06-02 Carolyn J. Huang, Benjamin A. Adler, Jennifer A. Doudna
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A journey from phosphotyrosine to phosphohistidine and beyond Mol. Cell (IF 17.97) Pub Date : 2022-06-01 Tony Hunter
Protein phosphorylation is a reversible post-translational modification. Nine of the 20 natural amino acids in proteins can be phosphorylated, but most of what we know about the roles of protein phosphorylation has come from studies of serine, threonine, and tyrosine phosphorylation. Much less is understood about the phosphorylation of histidine, lysine, arginine, cysteine, aspartate, and glutamate
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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1 Mol. Cell (IF 17.97) Pub Date : 2022-05-24 Wenjing Su, Radha Mukherjee, Rona Yaeger, Jieun Son, Jianing Xu, Na Na, Neilawattie Merna Timaul, Jaclyn Hechtman, Viktoriya Paroder, Mika Lin, Marissa Mattar, Juan Qiu, Qing Chang, Huiyong Zhao, Jonathan Zhang, Megan Little, Yuta Adachi, Sae-Won Han, Neal Rosen
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Lack of Cas13a inhibition by anti-CRISPR proteins from Leptotrichia prophages Mol. Cell (IF 17.97) Pub Date : 2022-05-26 Matthew C. Johnson, Logan T. Hille, Benjamin P. Kleinstiver, Alexander J. Meeske, Joseph Bondy-Denomy
CRISPR systems are prokaryotic adaptive immune systems that use RNA-guided Cas nucleases to recognize and destroy foreign genetic elements. To overcome CRISPR immunity, bacteriophages have evolved diverse families of anti-CRISPR proteins (Acrs). Recently, Lin et al. (2020) described the discovery and characterization of 7 Acr families (AcrVIA1-7) that inhibit type VI-A CRISPR systems. We detail several
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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination Mol. Cell (IF 17.97) Pub Date : 2022-05-20 Jiao Zhao, Shanshan Tian, Qiushi Guo, Kaiwen Bao, Guohui Yu, Xiaodan Wang, Xilin Shen, Jieyou Zhang, Jiaxin Chen, Ying Yang, Ling Liu, Xiangchun Li, Jihui Hao, Na Yang, Zhe Liu, Ding Ai, Jie Yang, Yi Zhu, Lei Shi
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Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate Mol. Cell (IF 17.97) Pub Date : 2022-05-20 Swantje Liedmann, Xueyan Liu, Clifford S. Guy, Jeremy Chase Crawford, Diego A. Rodriguez, Duygu Kuzuoğlu-Öztürk, Ao Guo, Katherine C. Verbist, Jamshid Temirov, Mark J. Chen, Davide Ruggero, Hui Zhang, Paul G. Thomas, Douglas R. Green
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Activation and closed-state inactivation mechanisms of the human voltage-gated KV4 channel complexes Mol. Cell (IF 17.97) Pub Date : 2022-05-20 Wenlei Ye, Hongtu Zhao, Yaxin Dai, Yingdi Wang, Yu-hua Lo, Lily Yeh Jan, Chia-Hsueh Lee
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DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production Mol. Cell (IF 17.97) Pub Date : 2022-05-19 Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Reika Kawabata-Iwakawa, Sayako Katada, Wenchao Gu, Sangeeta Kakoti, Motohiro Yamauchi, Reona Kato, Soehartati Gondhowiardjo, Naoki Hosen, Takaaki Yasuhara, Atsushi Shibata
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Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation Mol. Cell (IF 17.97) Pub Date : 2022-05-18 Hui Shen, Amber Yanas, Michael C. Owens, Celia Zhang, Clark Fritsch, Charlotte M. Fare, Katie E. Copley, James Shorter, Yale E. Goldman, Kathy Fange Liu
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Meet the authors: Bin Jiang and Qinxi Li Mol. Cell (IF 17.97) Pub Date : 2022-05-19
Small-town wonder and inquisitive minds overcome pandemic hardships. Here, we talk to first author Bin Jiang and group leader Qinxi Li about their paper, “Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis,” and Qinxi tells us about his lab’s research and perseverance during lockdowns.
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Maintaining home integrity by bacterial pathogens: Disruption for the sake of construction Mol. Cell (IF 17.97) Pub Date : 2022-05-19 Lei Song, Zhao-Qing Luo
Caspases are often considered the final checkpoint for a pathogen to save its replicative niche from collapsing after cell death signaling has been initiated in response to infection. Two recent works (Li et al., 2021; Peng et al., 2022) found that pathogens inhibit host cell death by inactivating multiple caspases with a novel posttranslational modification.
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Dangerous RNA links pave the way to glioblastoma Mol. Cell (IF 17.97) Pub Date : 2022-05-19 Magda Bienko
A new study by Deforzh et al. (2022) demonstrates how two long non-coding RNAs (lncRNAs) link a distal enhancer to the HOXD3/D4/miR-10b gene promoter, leading to transcriptional activation of the therapeutic target miR-10b in glioblastoma multiforme.
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Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death Mol. Cell (IF 17.97) Pub Date : 2022-05-19 Paul A. Cobine, Donita C. Brady
Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.
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A hexasome is the preferred substrate for the INO80 chromatin remodeling complex, allowing versatility of function Mol. Cell (IF 17.97) Pub Date : 2022-05-20 Laura J. Hsieh, Muryam A. Gourdet, Camille M. Moore, Elise N. Muñoz, Nathan Gamarra, Vijay Ramani, Geeta J. Narlikar
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Mpe1 senses the binding of pre-mRNA and controls 3′ end processing by CPF Mol. Cell (IF 17.97) Pub Date : 2022-05-17 Juan B. Rodríguez-Molina, Francis J. O’Reilly, Holly Fagarasan, Eleanor Sheekey, Sarah Maslen, J. Mark Skehel, Juri Rappsilber, Lori A. Passmore
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Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells Mol. Cell (IF 17.97) Pub Date : 2022-05-16 Rémi Planès, Miriam Pinilla, Karin Santoni, Audrey Hessel, Charlotte Passemar, Kenneth Lay, Perrine Paillette, Ana-Luiza Chaves Valadão, Kim Samirah Robinson, Paul Bastard, Nathaniel Lam, Ricardo Fadrique, Ida Rossi, David Pericat, Salimata Bagayoko, Stephen Adonai Leon-Icaza, Yoann Rombouts, Eric Perouzel, Etienne Meunier
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Exploiting replication gaps for cancer therapy Mol. Cell (IF 17.97) Pub Date : 2022-05-13 Ke Cong, Sharon B. Cantor
Defects in DNA double-strand break repair are thought to render BRCA1 or BRCA2 (BRCA) mutant tumors selectively sensitive to PARP inhibitors (PARPis). Challenging this framework, BRCA and PARP1 share functions in DNA synthesis on the lagging strand. Thus, BRCA deficiency or “BRCAness” could reflect an inherent lagging strand problem that is vulnerable to drugs such as PARPi that also target the lagging
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Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions Mol. Cell (IF 17.97) Pub Date : 2022-05-11 Julien Vibert, Olivier Saulnier, Céline Collin, Floriane Petit, Kyra J.E. Borgman, Jérômine Vigneau, Maud Gautier, Sakina Zaidi, Gaëlle Pierron, Sarah Watson, Nadège Gruel, Clémence Hénon, Sophie Postel-Vinay, Marc Deloger, Virginie Raynal, Sylvain Baulande, Karine Laud-Duval, Véronique Hill, Olivier Delattre
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Exploring molecular biology in sequence space: The road to next-generation single-molecule biophysics Mol. Cell (IF 17.97) Pub Date : 2022-05-12 Ivo Severins, Chirlmin Joo, John van Noort
Next-generation sequencing techniques have led to a new quantitative dimension in the biological sciences. In particular, integrating sequencing techniques with biophysical tools allows sequence-dependent mechanistic studies. Using the millions of DNA clusters that are generated during sequencing to perform high-throughput binding affinity and kinetics measurements enabled the construction of energy
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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition Mol. Cell (IF 17.97) Pub Date : 2022-05-09 Yiannis Drosos, Jacquelyn A. Myers, Beisi Xu, Kaeli M. Mathias, Emma C. Beane, Sandi Radko-Juettner, Robert J. Mobley, Margaret E. Larsen, Federica Piccioni, Xiaotu Ma, Jonathan Low, Baranda S. Hansen, Samuel T. Peters, Natarajan V. Bhanu, Sandeep K. Dhanda, Taosheng Chen, Santhosh A. Upadhyaya, Shondra M. Pruett-Miller, Charles W.M. Roberts