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Structure of the multi-subunit chloroplast RNA polymerase Mol. Cell (IF 16.0) Pub Date : 2024-02-29 Paula F.V. do Prado, Frederik M. Ahrens, Monique Liebers, Noah Ditz, Hans-Peter Braun, Thomas Pfannschmidt, Hauke S. Hillen
Chloroplasts contain a dedicated genome that encodes subunits of the photosynthesis machinery. Transcription of photosynthesis genes is predominantly carried out by a plastid-encoded RNA polymerase (PEP), a nearly 1 MDa complex composed of core subunits with homology to eubacterial RNA polymerases (RNAPs) and at least 12 additional chloroplast-specific PEP-associated proteins (PAPs). However, the architecture
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Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology Mol. Cell (IF 16.0) Pub Date : 2024-02-29 Gayathri Muthukumar, Taylor A. Stevens, Alison J. Inglis, Theodore K. Esantsi, Reuben A. Saunders, Fabian Schulte, Rebecca M. Voorhees, Alina Guna, Jonathan S. Weissman
Mitochondrial outer membrane ⍺-helical proteins play critical roles in mitochondrial-cytoplasmic communication, but the rules governing the targeting and insertion of these biophysically diverse proteins remain unknown. Here, we first defined the complement of required mammalian biogenesis machinery through genome-wide CRISPRi screens using topologically distinct membrane proteins. Systematic analysis
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Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing Mol. Cell (IF 16.0) Pub Date : 2024-02-23 Bonnie G. Su, Seychelle M. Vos
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Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation Mol. Cell (IF 16.0) Pub Date : 2024-02-23 Hao Li, Zhejian Ji, Joao A. Paulo, Steven P. Gygi, Tom A. Rapoport
Most eukaryotic proteins are degraded by the 26S proteasome after modification with a polyubiquitin chain. Substrates lacking unstructured segments cannot be degraded directly and require prior unfolding by the Cdc48 ATPase (p97 or VCP in mammals) in complex with its ubiquitin-binding partner Ufd1-Npl4 (UN). Here, we use purified yeast components to reconstitute Cdc48-dependent degradation of well-folded
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Discovery of cytosine deaminases enables base-resolution methylome mapping using a single enzyme Mol. Cell (IF 16.0) Pub Date : 2024-02-22 Romualdas Vaisvila, Sean R. Johnson, Bo Yan, Nan Dai, Billal M. Bourkia, Minyong Chen, Ivan R. Corrêa, Erbay Yigit, Zhiyi Sun
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Single-molecule tracking reveals the functional allocation, in vivo interactions, and spatial organization of universal transcription factor NusG Mol. Cell (IF 16.0) Pub Date : 2024-02-21 Hafez El Sayyed, Oliver J. Pambos, Mathew Stracy, Max E. Gottesman, Achillefs N. Kapanidis
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Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo Mol. Cell (IF 16.0) Pub Date : 2024-02-21 Jimmy K. Guo, Mario R. Blanco, Ward G. Walkup, Grant Bonesteele, Carl R. Urbinati, Abhik K. Banerjee, Amy Chow, Olivia Ettlin, Mackenzie Strehle, Parham Peyda, Enrique Amaya, Vickie Trinh, Mitchell Guttman
Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate gene expression. Yet, there is a growing discrepancy between the biochemical evidence supporting specific lncRNA-PRC2 interactions and functional evidence demonstrating that PRC2 is often dispensable for lncRNA function. Here, we revisit the
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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting Mol. Cell (IF 16.0) Pub Date : 2024-02-20 Jerry Li, Nicholas Purser, Joanna Liwocha, Daniel C. Scott, Holly A. Byers, Barbara Steigenberger, Spencer Hill, Ishita Tripathi-Giesgen, Trent Hinkle, Fynn M. Hansen, J. Rajan Prabu, Senthil K. Radhakrishnan, Donald S. Kirkpatrick, Kurt M. Reichermeier, Brenda A. Schulman, Gary Kleiger
Cullin-RING ligases (CRLs) ubiquitylate specific substrates selected from other cellular proteins. Substrate discrimination and ubiquitin transferase activity were thought to be strictly separated. Substrates are recognized by substrate receptors, such as Fbox or BCbox proteins. Meanwhile, CRLs employ assorted ubiquitin-carrying enzymes (UCEs, which are a collection of E2 and ARIH-family E3s) specialized
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity Mol. Cell (IF 16.0) Pub Date : 2024-02-19 Chuan He, Xixin Xing, Hsin-Yi Chen, Minling Gao, Jie Shi, Bolin Xiang, Xiangling Xiao, Yishuang Sun, Haisheng Yu, Gaoshan Xu, Yingmeng Yao, Zuosong Xie, Yujie Xing, Bugi Ratno Budiarto, Shih-Yu Chen, Yang Gao, Yu-Ru Lee, Jinfang Zhang
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Transcription factor exchange enables prolonged transcriptional bursts Mol. Cell (IF 16.0) Pub Date : 2024-02-19 Wim Pomp, Joseph V.W. Meeussen, Tineke L. Lenstra
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Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing Mol. Cell (IF 16.0) Pub Date : 2024-02-19 Yan He, Xibin Zhou, Chong Chang, Ge Chen, Weikuan Liu, Geng Li, Xiaoqi Fan, Mingsun Sun, Chensi Miao, Qianyue Huang, Yunqing Ma, Fajie Yuan, Xing Chang
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Meet the authors: Nico Wahl, Georg Dechant, and Galina Apostolova Mol. Cell (IF 16.0) Pub Date : 2024-02-15 Nico Wahl, Georg Dechant, Galina Apostolova
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Transcription complexes recruit a chaperone to perform cotranscriptional processing of tRNA Mol. Cell (IF 16.0) Pub Date : 2024-02-15 Nayef Jarrous, Dhivakar Mani
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Peptidyl-tRNA hydrolase as a key player in the liberation of truncated nascent chains from the ribosomal subunit Mol. Cell (IF 16.0) Pub Date : 2024-02-15 Marina V. Rodnina
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SLC25A39 links mitochondrial GSH sensing with iron metabolism Mol. Cell (IF 16.0) Pub Date : 2024-02-15 Xiong Chen, Boyi Gan
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C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line Mol. Cell (IF 16.0) Pub Date : 2024-02-14 Ansgar Zoch, Gabriela Konieczny, Tania Auchynnikava, Birgit Stallmeyer, Nadja Rotte, Madeleine Heep, Rebecca V. Berrens, Martina Schito, Yuka Kabayama, Theresa Schöpp, Sabine Kliesch, Brendan Houston, Liina Nagirnaja, Moira K. O’Bryan, Kenneth I. Aston, Donald F. Conrad, Juri Rappsilber, Robin C. Allshire, Atlanta G. Cook, Frank Tüttelmann, Dónal O’Carroll
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Specialized replication mechanisms maintain genome stability at human centromeres Mol. Cell (IF 16.0) Pub Date : 2024-02-14 Andrea Scelfo, Annapaola Angrisani, Marco Grillo, Bethany M. Barnes, Francesc Muyas, Carolin M. Sauer, Chin Wei Brian Leung, Marie Dumont, Marine Grison, David Mazaud, Mickaël Garnier, Laetitia Guintini, Louisa Nelson, Fumiko Esashi, Isidro Cortés-Ciriano, Stephen S. Taylor, Jérôme Déjardin, Therese Wilhelm, Daniele Fachinetti
The high incidence of whole-arm chromosome aneuploidy and translocations in tumors suggests instability of centromeres, unique loci built on repetitive sequences and essential for chromosome separation. The causes behind this fragility and the mechanisms preserving centromere integrity remain elusive. We show that replication stress, hallmark of pre-cancerous lesions, promotes centromeric breakage
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The HRI branch of the integrated stress response selectively triggers mitophagy Mol. Cell (IF 16.0) Pub Date : 2024-02-09 Yogaditya Chakrabarty, Zheng Yang, Hsiuchen Chen, David C. Chan
To maintain mitochondrial homeostasis, damaged or excessive mitochondria are culled in coordination with the physiological state of the cell. The integrated stress response (ISR) is a signaling network that recognizes diverse cellular stresses, including mitochondrial dysfunction. Because the four ISR branches converge to common outputs, it is unclear whether mitochondrial stress detected by this network
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Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells Mol. Cell (IF 16.0) Pub Date : 2024-02-09 Juliette Fedry, Joana Silva, Mihajlo Vanevic, Stanley Fronik, Yves Mechulam, Emmanuelle Schmitt, Amédée des Georges, William James Faller, Friedrich Förster
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Persistence of backtracking by human RNA polymerase II Mol. Cell (IF 16.0) Pub Date : 2024-02-09 Kevin B. Yang, Aviram Rasouly, Vitaly Epshtein, Criseyda Martinez, Thao Nguyen, Ilya Shamovsky, Evgeny Nudler
RNA polymerase II (RNA Pol II) can backtrack during transcription elongation, exposing the 3′ end of nascent RNA. Nascent RNA sequencing can approximate the location of backtracking events that are quickly resolved; however, the extent and genome-wide distribution of more persistent backtracking are unknown. Consequently, we developed a method to directly sequence the extruded, “backtracked” 3′ RNA
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Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91 Mol. Cell (IF 16.0) Pub Date : 2024-02-06 Aslihan Shenol, Michael Lückmann, Mette Trauelsen, Matteo Lambrughi, Matteo Tiberti, Elena Papaleo, Thomas M. Frimurer, Thue W. Schwartz
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The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs Mol. Cell (IF 16.0) Pub Date : 2024-02-06 Shu Yang, Chun-Yuan Ting, Mary A. Lilly
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Loop-extruding Smc5/6 organizes transcription-induced positive DNA supercoils Mol. Cell (IF 16.0) Pub Date : 2024-01-30 Kristian Jeppsson, Biswajit Pradhan, Takashi Sutani, Toyonori Sakata, Miki Umeda Igarashi, Davide Giorgio Berta, Takaharu Kanno, Ryuichiro Nakato, Katsuhiko Shirahige, Eugene Kim, Camilla Björkegren
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IκBζ is a dual-use coactivator of NF-κB and POU transcription factors Mol. Cell (IF 16.0) Pub Date : 2024-02-02 Aktan Alpsoy, Xiaoli S. Wu, Sujay Pal, Olaf Klingbeil, Pramod Kumar, Osama El Demerdash, Benan Nalbant, Christopher R. Vakoc
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Alternative polyadenylation determines the functional landscape of inverted Alu repeats Mol. Cell (IF 16.0) Pub Date : 2024-02-02 Jayoung Ku, Keonyong Lee, Doyeong Ku, Sujin Kim, Jongbin Lee, Hyunwoo Bang, Namwook Kim, Hyunsu Do, Hyeonjung Lee, Chunghun Lim, Jinju Han, Young-suk Lee, Yoosik Kim
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Structural basis for plasmid restriction by SMC JET nuclease Mol. Cell (IF 16.0) Pub Date : 2024-02-02 Florian Roisné-Hamelin, Hon Wing Liu, Michael Taschner, Yan Li, Stephan Gruber
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Out with the old, in with the new: Pioneer transcription factors as activators and repressors of lineage specification genes Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Yang Liu, Paul A. Wade
In this issue of Molecular Cell, Matsui et al.1 examine lineage determination by pioneer transcription factors, finding that they control cell fate in cooperation with PRDM family members by repressing alternative-lineage and precocious gene expression through establishment of bivalent enhancers.
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Meet the authors: Vasty Osei Amponsa and Kylie J. Walters Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Vasty Osei Amponsa, Kylie J. Walters
We talk to Vasty Osei Amponsa and Kylie J. Walters about their paper “hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50”, their journeys across continents leading them to the NCI, and how Kylie tries to foster curiosity and a sense of belonging in her lab.
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AlphaFold: Research accelerator and hypothesis generator Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Elizabeth A. Campbell, Helen Walden, Johannes C. Walter, Arun K. Shukla, Martin Beck, Lori A. Passmore, H. Eric Xu
To celebrate the 50th anniversary of Cell Press and the Cell focus issue on structural biology, we discussed with scientists working across diverse fields how AlphaFold has changed their research and brought structural biology to the masses.
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DNA repair, gap suppression, or fork protection: BRCA2 needs a break! Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Diego Dibitetto, Sven Rottenberg
In this issue of Molecular Cell, Lim et al.1 reveal new insights into the distinct roles of BRCA2 in coping with DNA breaks, highlighting homologous recombination as the pivotal function that affects tumorigenesis and therapy response.
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BREACHing new grounds in fragile X syndrome: Trinucleotide expansion linked to genome-wide heterochromatin domains and genome misfolding Mol. Cell (IF 16.0) Pub Date : 2024-02-01 Edda G. Schulz
In a recent study in Cell, Malachowski et al.1 show that the trinucleotide expansion in the FMR1 gene underlying fragile X syndrome triggers formation of large heterochromatin domains across the genome, resulting in the repression of synaptic genes housed within these domains.
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CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs Mol. Cell (IF 16.0) Pub Date : 2024-01-30 Rachel Anderson, Michael R. Das, Yeonji Chang, Kelsey Farenhem, Cameron O. Schmitz, Ankur Jain
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COQ4 is required for the oxidative decarboxylation of the C1 carbon of coenzyme Q in eukaryotic cells Mol. Cell (IF 16.0) Pub Date : 2024-01-30 Ludovic Pelosi, Laura Morbiato, Arthur Burgardt, Fiorella Tonello, Abigail K. Bartlett, Rachel M. Guerra, Katayoun Kazemzadeh Ferizhendi, Maria Andrea Desbats, Bérengère Rascalou, Marco Marchi, Luis Vázquez-Fonseca, Caterina Agosto, Giuseppe Zanotti, Morgane Roger-Margueritat, María Alcázar-Fabra, Laura García-Corzo, Ana Sánchez-Cuesta, Plácido Navas, Gloria Brea-Calvo, Eva Trevisson, Fabien Pierrel
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Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute Mol. Cell (IF 16.0) Pub Date : 2024-01-30 Longyu Wang, Wanping Chen, Chendi Zhang, Xiaochen Xie, Fuyong Huang, Miaomiao Chen, Wuxiang Mao, Na Yu, Qiang Wei, Lixin Ma, Zhuang Li
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PARP5A and RNF146 phase separation restrains RIPK1-dependent necroptosis Mol. Cell (IF 16.0) Pub Date : 2024-01-24 Shouqiao Hou, Jian Zhang, Xiaoyan Jiang, Yuanxin Yang, Bing Shan, Mengmeng Zhang, Cong Liu, Junying Yuan, Daichao Xu
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BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution Mol. Cell (IF 16.0) Pub Date : 2024-01-23 Kaima Tsukada, Samuel E. Jones, Julius Bannister, Mary-Anne Durin, Iolanda Vendrell, Matthew Fawkes, Roman Fischer, Benedikt M. Kessler, J. Ross Chapman, Andrew N. Blackford
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Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation Mol. Cell (IF 16.0) Pub Date : 2024-01-23 Chuanlong Wang, Qingyi Chen, Siyuan Chen, Lijuan Fan, Zhending Gan, Muyang Zhao, Lexuan Shi, Peng Bin, Guan Yang, Xihong Zhou, Wenkai Ren
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EXO1 protects BRCA1-deficient cells against toxic DNA lesions Mol. Cell (IF 16.0) Pub Date : 2024-01-23 Bert van de Kooij, Anne Schreuder, Raphael Pavani, Veronica Garzero, Sidrit Uruci, Tiemen J. Wendel, Arne van Hoeck, Marta San Martin Alonso, Marieke Everts, Dana Koerse, Elsa Callen, Jasper Boom, Hailiang Mei, Edwin Cuppen, Martijn S. Luijsterburg, Marcel A.T.M. van Vugt, André Nussenzweig, Haico van Attikum, Sylvie M. Noordermeer
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HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III Mol. Cell (IF 16.0) Pub Date : 2024-01-23 Sergio Leone, Avinash Srivastava, Andrés Herrero-Ruiz, Barbara Hummel, Lena Tittel, Roberto Campalastri, Fernando Aprile-Garcia, Jun Hao Tan, Prashant Rawat, Patrik Andersson, Anne E. Willis, Ritwick Sawarkar
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Regulation of replicative histone RNA metabolism by the histone chaperone ASF1 Mol. Cell (IF 16.0) Pub Date : 2024-01-22 Shweta Mendiratta, Dominique Ray-Gallet, Sébastien Lemaire, Alberto Gatto, Audrey Forest, Maciej A. Kerlin, Geneviève Almouzni
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SATB2 organizes the 3D genome architecture of cognition in cortical neurons Mol. Cell (IF 16.0) Pub Date : 2024-01-19 Nico Wahl, Sergio Espeso-Gil, Paola Chietera, Amelie Nagel, Aodán Laighneach, Derek W. Morris, Prashanth Rajarajan, Schahram Akbarian, Georg Dechant, Galina Apostolova
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Mechanisms of RNF168 nucleosome recognition and ubiquitylation Mol. Cell (IF 16.0) Pub Date : 2024-01-18 Qi Hu, Debiao Zhao, Gaofeng Cui, Janarjan Bhandari, James R. Thompson, Maria Victoria Botuyan, Georges Mer
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Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide Mol. Cell (IF 16.0) Pub Date : 2024-01-18 Marta Russo, Francesco Gualdrini, Veronica Vallelonga, Elena Prosperini, Roberta Noberini, Silvia Pedretti, Carolina Borriero, Pierluigi Di Chiaro, Sara Polletti, Gabriele Imperato, Mattia Marenda, Chiara Ghirardi, Fabio Bedin, Alessandro Cuomo, Simona Rodighiero, Tiziana Bonaldi, Nico Mitro, Serena Ghisletti, Gioacchino Natoli
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Meet the authors: Yuqiu Sun and Hui Jiang Mol. Cell (IF 16.0) Pub Date : 2024-01-18 Yuqiu Sun, Hui Jiang
We talk to first author Yuqiu Sun and corresponding author Hui Jiang about their paths in science, mentorship, and the exciting moments in the journey towards their paper “A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass” (this issue of Molecular Cell).
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A quick restart: RNA polymerase jumping onto post-replicative chromatin Mol. Cell (IF 16.0) Pub Date : 2024-01-18 Marcel Werner, Stephan Hamperl
Two recent studies in Molecular Cell1 and Nature2 show that evicted RNA polymerases reassociate rapidly with post-replicative chromatin and proceed into an unusual transcription cycle, bypassing regular controls and creating a temporary window for altered gene expression.
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Actions speak louder than ORFs: A non-canonical microprotein promotes medulloblastoma oncogenesis Mol. Cell (IF 16.0) Pub Date : 2024-01-18 Alberto Delaidelli, Jessica Oliveira de Santis, Poul H. Sorensen
In this issue of Molecular Cell, Hofman et al.1 identify the translation of a non-canonical upstream open reading frame of the ASNSD1 gene into a microprotein that supports medulloblastoma growth.
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Enzymatic and non-enzymatic transnitrosylation: “SCAN”ning the SNO-proteome Mol. Cell (IF 16.0) Pub Date : 2024-01-18 Tomohiro Nakamura, Stuart A. Lipton
In a recent study in Cell, Zhou et al.1 propose enzymatic transfer of nitric-oxide (NO)-related species from SNO-CoA to target proteins involved in insulin signaling; this function comprises an SNO-CoA-Assisted Nitrosylase (SCAN).
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N6-methyladenosine in 5′ UTR does not promote translation initiation Mol. Cell (IF 16.0) Pub Date : 2024-01-19 Ewelina Guca, Rodrigo Alarcon, Michael Z. Palo, Leonardo Santos, Santiago Alonso-Gil, Marcos Davyt, Leonardo H.F. de Lima, Fanny Boissier, Sarada Das, Bojan Zagrovic, Joseph D. Puglisi, Yaser Hashem, Zoya Ignatova
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BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair Mol. Cell (IF 16.0) Pub Date : 2024-01-19 Pei Xin Lim, Mahdia Zaman, Weiran Feng, Maria Jasin
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Epigenetic regulatory layers in the 3D nucleus Mol. Cell (IF 16.0) Pub Date : 2024-01-18 Andréa Willemin, Dominik Szabó, Ana Pombo
Nearly 7 decades have elapsed since Francis Crick introduced the central dogma of molecular biology, as part of his ideas on protein synthesis, setting the fundamental rules of sequence information transfer from DNA to RNAs and proteins. We have since learned that gene expression is finely tuned in time and space, due to the activities of RNAs and proteins on regulatory DNA elements, and through cell-type-specific
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Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications Mol. Cell (IF 16.0) Pub Date : 2024-01-18 Chunyi Hu, Mason T. Myers, Xufei Zhou, Zhonggang Hou, Macy L. Lozen, Ki Hyun Nam, Yan Zhang, Ailong Ke
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A GAPDH serotonylation system couples CD8+ T cell glycolytic metabolism to antitumor immunity Mol. Cell (IF 16.0) Pub Date : 2024-01-11 Xu Wang, Sheng-Qiao Fu, Xiao Yuan, Feng Yu, Qian Ji, Hao-Wen Tang, Rong-Kun Li, Shan Huang, Pei-Qi Huang, Wei-Ting Qin, Hao Zuo, Chang Du, Lin-Li Yao, Hui Li, Jun Li, Dong-Xue Li, Yan Yang, Shu-Yu Xiao, Aziguli Tulamaiti, Xue-Feng Wang, Zhi-Gang Zhang
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Poly(ADP-ribosyl)ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates Mol. Cell (IF 16.0) Pub Date : 2024-01-11 Michael L. Nosella, Tae Hun Kim, Shuya Kate Huang, Robert W. Harkness, Monica Goncalves, Alisia Pan, Maria Tereshchenko, Siavash Vahidi, John L. Rubinstein, Hyun O. Lee, Julie D. Forman-Kay, Lewis E. Kay
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Conformational transitions and activation of the adhesion receptor CD97 Mol. Cell (IF 16.0) Pub Date : 2024-01-11 Chunyou Mao, Ru-Jia Zhao, Ying-Jun Dong, Mingxin Gao, Li-Nan Chen, Chao Zhang, Peng Xiao, Jia Guo, Jiao Qin, Dan-Dan Shen, Su-Yu Ji, Shao-Kun Zang, Huibing Zhang, Wei-Wei Wang, Qingya Shen, Jin-Peng Sun, Yan Zhang
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Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome Mol. Cell (IF 16.0) Pub Date : 2024-01-11 Xinran Feng, Xiaolong Cui, Li-Sheng Zhang, Chang Ye, Pingluan Wang, Yuhao Zhong, Tong Wu, Zhong Zheng, Chuan He
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Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma Mol. Cell (IF 16.0) Pub Date : 2024-01-10 Lianxin Hu, Yanfeng Zhang, Lei Guo, Hua Zhong, Ling Xie, Jin Zhou, Chengheng Liao, Hongwei Yao, Jun Fang, Hongyi Liu, Cheng Zhang, Hui Zhang, Xiaoqiang Zhu, Maowu Luo, Alex von Kriegsheim, Bufan Li, Weibo Luo, Xuewu Zhang, Xian Chen, Joshua T. Mendell, Qing Zhang
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Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate Mol. Cell (IF 16.0) Pub Date : 2024-01-10 Satoshi Matsui, Marissa Granitto, Morgan Buckley, Katie Ludwig, Sandra Koigi, Joseph Shiley, William J. Zacharias, Christopher N. Mayhew, Hee-Woong Lim, Makiko Iwafuchi
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METTL17 is an Fe-S cluster checkpoint for mitochondrial translation Mol. Cell (IF 16.0) Pub Date : 2024-01-09 Tslil Ast, Yuzuru Itoh, Shayan Sadre, Jason G. McCoy, Gil Namkoong, Jordan C. Wengrod, Ivan Chicherin, Pallavi R. Joshi, Piotr Kamenski, Daniel L.M. Suess, Alexey Amunts, Vamsi K. Mootha
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Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria Mol. Cell (IF 16.0) Pub Date : 2024-01-09 Sabine Poerschke, Silke Oeljeklaus, Luis Daniel Cruz-Zaragoza, Alexander Schenzielorz, Drishan Dahal, Hauke Sven Hillen, Hirak Das, Laura Sophie Kremer, Anusha Valpadashi, Mirjam Breuer, Johannes Sattmann, Ricarda Richter-Dennerlein, Bettina Warscheid, Sven Dennerlein, Peter Rehling
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Exquisite exposure: Formaldehyde as a metabolic regulator Mol. Cell (IF 16.0) Pub Date : 2024-01-04 Gabriela Ramirez-Hernandez, Nora Kory
Throughout life, whether through external consumption or internal production, we are exposed to different reactive metabolites considered toxic to the body. Pham et al.1 uncover metabolic regulation by one such harmful metabolite: formaldehyde.