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Competition shapes the landscape of X-chromosome-linked genetic diversity Nat. Genet. (IF 31.7) Pub Date : 2024-07-26 Teresa Buenaventura, Hakan Bagci, Ilinca Patrascan, Joshua J. Graham, Kelsey D. Hipwell, Roel Oldenkamp, James W. D. King, Jesus Urtasun, George Young, Daniel Mouzo, David Gomez-Cabrero, Benjamin D. Rowland, Daniel Panne, Amanda G. Fisher, Matthias Merkenschlager
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The rise of patient avatars in precision oncology Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-26 Lukas Ehlen, Michael Schmueck-Henneresse
Response to anticancer treatment is dictated not only by availability of molecular targets within the tumor, but also by the highly heterogenous, patient-specific composition of cells within tumors and their complex tumor microenvironment (TME). Consequently, some patients demonstrate remarkable responses to anticancer therapies, whereas others experience negligible effects. Thus, there is an urgent
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Audio long read: Hope, despair and CRISPR — the race to save one woman’s life Nature (IF 50.5) Pub Date : 2024-07-26
Listen to an audio version of a recent Nature Feature.
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How the rose got its iconic fragrance Nature (IF 50.5) Pub Date : 2024-07-26
A bouquet of genes involved in making volatile compounds helps to produce the flower’s characteristic scent.
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Seventh patient ‘cured’ of HIV: why scientists are excited Nature (IF 50.5) Pub Date : 2024-07-26
A man in Germany is HIV-free after receiving stem cells that are not resistant to the virus.
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Meet the retired scientists who collaborate with younger colleagues Nature (IF 50.5) Pub Date : 2024-07-26
Julie Gould learns that age is no barrier to enjoying interesting work and life opportunities in retirement.
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V. Craig Jordan obituary: pharmacologist who revolutionized breast cancer treatments Nature (IF 50.5) Pub Date : 2024-07-25
Pioneer of targeted therapy in cancer who turned failed contraceptive tamoxifen into an essential drug for treating breast cancer and osteoporosis.
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DeepMind hits milestone in solving maths problems — AI’s next grand challenge Nature (IF 50.5) Pub Date : 2024-07-25
AlphaProof showed its prowess on questions from this year’s Mathematical Olympiad — a step in the race to create substantial proofs with artificial intelligence.
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These brain cells help days-old mice to bond with mum Nature (IF 50.5) Pub Date : 2024-07-25
Scientists pinpoint neurons that encode the mother–baby bond in the brains of infant mice.
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Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5 Cell (IF 45.5) Pub Date : 2024-07-25
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Diabetes mellitus—Progress and opportunities in the evolving epidemic Cell (IF 45.5) Pub Date : 2024-07-25
Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads to complications that reduce quality of life and increase mortality. Diabetes pathophysiology includes dysfunction of beta cells, adipose tissue, skeletal muscle, and liver. Type 1 diabetes (T1D) results from immune-mediated beta cell destruction. The more prevalent type 2 diabetes (T2D) is a heterogeneous disorder
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Metabolic heterogeneity in humans Cell (IF 45.5) Pub Date : 2024-07-25
Recent advancements in technology, especially the emergence of single-cell technologies, genomic sequencing, metabolomics, and artificial intelligence, have enabled us to understand the distinct metabolic changes in different cell types, tissues, genders, disease states, ages, and populations. Six scientists whose work intersects with metabolism in various capacities tell us about their vision for
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100 years of the Warburg effect: A cancer metabolism endeavor Cell (IF 45.5) Pub Date : 2024-07-25
If you are a scientist and you only know one thing about tumor metabolism, it’s likely the Warburg effect. But who was Otto Warburg, and how did his discoveries regarding the metabolism of tumors shape our current thinking about the metabolic needs of cancer cells?
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Transforming obesity: The advancement of multi-receptor drugs Cell (IF 45.5) Pub Date : 2024-07-25
For more than a century, physicians have searched for ways to pharmacologically reduce excess body fat. The tide has finally turned with recent advances in biochemically engineered agonists for the receptor of glucagon-like peptide-1 (GLP-1) and their use in GLP-1-based polyagonists. These polyagonists reduce body weight through complementary pharmacology by incorporating the receptors for glucagon
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A metabolic balance of GLP-1 and NMDA receptors in the brain Cell (IF 45.5) Pub Date : 2024-07-25
Glucagon-like peptide-1 (GLP-1) and N-methyl-D-aspartate (NMDA) receptors in the brain regulate metabolic homeostasis. In a paper published in Nature, Petersen et al. describe a bimodal molecule that conjugates a GLP-1 analog with MK-801 (NMDA receptor antagonist), which lowers feeding and body weight to a greater extent than the GLP-1R agonist alone.
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Digesting the complex metabolic effects of diet on the host and microbiome Cell (IF 45.5) Pub Date : 2024-07-25
The past 50 years of interdisciplinary research in humans and model organisms has delivered unprecedented insights into the mechanisms through which diet affects energy balance. However, translating these results to prevent and treat obesity and its associated diseases remains challenging. Given the vast scope of this literature, we focus this Review on recent conceptual advances in molecular nutrition
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Metabolism in the spotlight: Dr. Giles Yeo on the impact and challenges of science communication Cell (IF 45.5) Pub Date : 2024-07-25
In this interview with Cell, Dr. Giles Yeo shares his journey into metabolism research, his strategies for engaging audiences, and the challenges of simplifying complex concepts. He also discusses the impact of social media, the advantages of podcasting, and the question he’s most afraid of.
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Translating metabolic and cardiovascular research into effective treatments: What’s next? Cell (IF 45.5) Pub Date : 2024-07-25
The future of healthcare for cardiovascular diseases holds immense promise, not only based in new discoveries in cardiac metabolism but also in translating them to solutions for critical challenges faced by society. Here, ten scientists share their insights, shedding light on the future that lies ahead for this field.
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“Boosting” tumor immunity in elderly mice by hyperactivating dendritic cells Cell (IF 45.5) Pub Date : 2024-07-25
Immunosenescence poses a significant challenge to tumor immunotherapy in elderly individuals. In this issue of Cell, Zhivaki et al. elucidate that dendritic cells “hyperactivated” by specific adjuvants elicit TH1-skewed CD4+ T cell responses in a manner contingent on the NLRP3 inflammasome, which can eliminate tumors in aged mice.
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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 9.4) Pub Date : 2024-07-23
Proceedings of the National Academy of Sciences, Volume 121, Issue 30, July 2024.
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A mini-colon models colon cancer and its microenvironment Nat. Biotechnol. (IF 33.1) Pub Date : 2024-07-25 Colin Hutton, Vivian S. W. Li
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Three ways AI is changing the 2024 Olympics for athletes and fans Nature (IF 50.5) Pub Date : 2024-07-25
From training to broadcasting, artificial intelligence will have an imprint on this year’s event for the first time.
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AI is vulnerable to attack. Can it ever be used safely? Nature (IF 50.5) Pub Date : 2024-07-25
The models that underpin artificial-intelligence systems such as ChatGPT can be subject to attacks that elicit harmful behaviour. Making them safe will not be easy.
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India budget: Modi bets big on nuclear energy and space Nature (IF 50.5) Pub Date : 2024-07-25
The government has focused on areas of national pride and applied science, as many researchers expected.
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Memory for music doesn’t diminish with age Nature (IF 50.5) Pub Date : 2024-07-24
Eighty-year-olds are able to identify familiar tunes just as well as teenagers can.
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AI models collapse when trained on recursively generated data Nature (IF 50.5) Pub Date : 2024-07-24 Ilia Shumailov, Zakhar Shumaylov, Yiren Zhao, Nicolas Papernot, Ross Anderson, Yarin Gal
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Blood culture-free ultra-rapid antimicrobial susceptibility testing Nature (IF 50.5) Pub Date : 2024-07-24 Tae Hyun Kim, Junwon Kang, Haewook Jang, Hyelyn Joo, Gi Yoon Lee, Hamin Kim, Untack Cho, Hyeeun Bang, Jisung Jang, Sangkwon Han, Dong Young Kim, Chan Mi Lee, Chang Kyung Kang, Pyoeng Gyun Choe, Nam Joong Kim, Myoung-don Oh, Taek Soo Kim, Inho Kim, Wan Beom Park, Sunghoon Kwon
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Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain Nature (IF 50.5) Pub Date : 2024-07-24 Jennifer M. Kefauver, Markku Hakala, Luoming Zou, Josephine Alba, Javier Espadas, Maria G. Tettamanti, Jelena Gajić, Caroline Gabus, Pablo Campomanes, Leandro F. Estrozi, Nesli E. Sen, Stefano Vanni, Aurélien Roux, Ambroise Desfosses, Robbie Loewith
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A human autoimmune organoid model reveals IL-7 function in coeliac disease Nature (IF 50.5) Pub Date : 2024-07-24 António J. M. Santos, Vincent van Unen, Zhongqi Lin, Steven M. Chirieleison, Nhi Ha, Arpit Batish, Joshua E. Chan, Jose Cedano, Elisa T. Zhang, Qinghui Mu, Alexander Guh-Siesel, Madeline Tomaske, Deana Colburg, Sushama Varma, Shannon S. Choi, Asbjørn Christophersen, Ani Baghdasaryan, Kathryn E. Yost, Kasper Karlsson, Andrew Ha, Jing Li, Hongjie Dai, Zachary M. Sellers, Howard Y. Chang, James C. Y.
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Isolation of a methyl-reducing methanogen outside the Euryarchaeota Nature (IF 50.5) Pub Date : 2024-07-24 Kejia Wu, Lei Zhou, Guillaume Tahon, Laiyan Liu, Jiang Li, Jianchao Zhang, Fengfeng Zheng, Chengpeng Deng, Wenhao Han, Liping Bai, Lin Fu, Xiuzhu Dong, Chuanlun Zhang, Thijs J. G. Ettema, Diana Z. Sousa, Lei Cheng
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Cultivation and visualization of a methanogen of the phylum Thermoproteota Nature (IF 50.5) Pub Date : 2024-07-24 Anthony J. Kohtz, Nikolai Petrosian, Viola Krukenberg, Zackary J. Jay, Martin Pilhofer, Roland Hatzenpichler
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Deep, hot, ancient melting recorded by ultralow oxygen fugacity in peridotites Nature (IF 50.5) Pub Date : 2024-07-24 Suzanne K. Birner, Elizabeth Cottrell, Fred A. Davis, Jessica M. Warren
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Global net climate effects of anthropogenic reactive nitrogen Nature (IF 50.5) Pub Date : 2024-07-24 Cheng Gong, Hanqin Tian, Hong Liao, Naiqing Pan, Shufen Pan, Akihiko Ito, Atul K. Jain, Sian Kou-Giesbrecht, Fortunat Joos, Qing Sun, Hao Shi, Nicolas Vuichard, Qing Zhu, Changhui Peng, Federico Maggi, Fiona H. M. Tang, Sönke Zaehle
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Jurassic fossil juvenile reveals prolonged life history in early mammals Nature (IF 50.5) Pub Date : 2024-07-24 Elsa Panciroli, Roger B. J. Benson, Vincent Fernandez, Nicholas C. Fraser, Matt Humpage, Zhe-Xi Luo, Elis Newham, Stig Walsh
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Molecular basis of human noradrenaline transporter reuptake and inhibition Nature (IF 50.5) Pub Date : 2024-07-24 Jiaxin Tan, Yuan Xiao, Fang Kong, Xiaochun Zhang, Hanwen Xu, Angqi Zhu, Yiming Liu, Jianlin Lei, Boxue Tian, Yafei Yuan, Chuangye Yan
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Shifts in receptors during submergence of an encephalitic arbovirus Nature (IF 50.5) Pub Date : 2024-07-24 Wanyu Li, Jessica A. Plante, ChieYu Lin, Himanish Basu, Jesse S. Plung, Xiaoyi Fan, Joshua M. Boeckers, Jessica Oros, Tierra K. Buck, Praju V. Anekal, Wesley A. Hanson, Haley Varnum, Adrienne Wells, Colin J. Mann, Laurentia V. Tjang, Pan Yang, Rachel A. Reyna, Brooke M. Mitchell, Divya P. Shinde, Jordyn L. Walker, So Yoen Choi, Vesna Brusic, Paula Montero Llopis, Scott C. Weaver, Hisashi Umemori, Isaac
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Human TMEFF1 is a restriction factor for herpes simplex virus in the brain Nature (IF 50.5) Pub Date : 2024-07-24 Yi-Hao Chan, Zhiyong Liu, Paul Bastard, Noopur Khobrekar, Kennen M. Hutchison, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Nacim Kerrouche, Koji Nakajima, Param Amin, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayse Kartal, Mary L. Hasek, Shuxiang Zhao, Eduardo Garcia Reino
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Single-cell multiregion dissection of Alzheimer’s disease Nature (IF 50.5) Pub Date : 2024-07-24 Hansruedi Mathys, Carles A. Boix, Leyla Anne Akay, Ziting Xia, Jose Davila-Velderrain, Ayesha P. Ng, Xueqiao Jiang, Ghada Abdelhady, Kyriaki Galani, Julio Mantero, Neil Band, Benjamin T. James, Sudhagar Babu, Fabiola Galiana-Melendez, Kate Louderback, Dmitry Prokopenko, Rudolph E. Tanzi, David A. Bennett, Li-Huei Tsai, Manolis Kellis
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Multi-heterojunctioned plastics with high thermoelectric figure of merit Nature (IF 50.5) Pub Date : 2024-07-24 Dongyang Wang, Jiamin Ding, Yingqiao Ma, Chunlin Xu, Zhiyi Li, Xiao Zhang, Yao Zhao, Yue Zhao, Yuqiu Di, Liyao Liu, Xiaojuan Dai, Ye Zou, BongSoo Kim, Fengjiao Zhang, Zitong Liu, Iain McCulloch, Myeongjae Lee, Cheng Chang, Xiao Yang, Dong Wang, Deqing Zhang, Li-Dong Zhao, Chong-an Di, Daoben Zhu
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Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy Nature (IF 50.5) Pub Date : 2024-07-24 Hussein Sultan, Yoshiko Takeuchi, Jeffrey P. Ward, Naveen Sharma, Tian-Tian Liu, Vladimir Sukhov, Maria Firulyova, Yuang Song, Samuel Ameh, Simone Brioschi, Darya Khantakova, Cora D. Arthur, J. Michael White, Heather Kohlmiller, Andres M. Salazar, Robert Burns, Helio A. Costa, Kelly D. Moynihan, Yik Andy Yeung, Ivana Djuretic, Ton N. Schumacher, Kathleen C. F. Sheehan, Marco Colonna, James P. Allison
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Global atmospheric methane uptake by upland tree woody surfaces Nature (IF 50.5) Pub Date : 2024-07-24 Vincent Gauci, Sunitha Rao Pangala, Alexander Shenkin, Josep Barba, David Bastviken, Viviane Figueiredo, Carla Gomez, Alex Enrich-Prast, Emma Sayer, Tainá Stauffer, Bertie Welch, Dafydd Elias, Niall McNamara, Myles Allen, Yadvinder Malhi
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peri-Fused polyaromatic molecular contacts for perovskite solar cells Nature (IF 50.5) Pub Date : 2024-07-24 Ke Zhao, Qingqing Liu, Libing Yao, Caner Değer, Jiahui Shen, Xu Zhang, Pengju Shi, Yuan Tian, Yixin Luo, Jiazhe Xu, Jingjing Zhou, Donger Jin, Sisi Wang, Wei Fan, Shaochen Zhang, Shenglong Chu, Xiaonan Wang, Liuwen Tian, Ruzhang Liu, Li Zhang, Ilhan Yavuz, Hong-fei Wang, Deren Yang, Rui Wang, Jingjing Xue
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In vivo interaction screening reveals liver-derived constraints to metastasis Nature (IF 50.5) Pub Date : 2024-07-24 Costanza Borrelli, Morgan Roberts, Davide Eletto, Marie-Didiée Hussherr, Hassan Fazilaty, Tomas Valenta, Atefeh Lafzi, Jonas A. Kretz, Elena Guido Vinzoni, Andromachi Karakatsani, Srivathsan Adivarahan, Ardian Mannhart, Shoichiro Kimura, Ab Meijs, Farah Baccouche Mhamedi, Ilhan E. Acar, Kristina Handler, Xenia Ficht, Randall J. Platt, Salvatore Piscuoglio, Andreas E. Moor
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TMEFF1 is a neuron-specific restriction factor for herpes simplex virus Nature (IF 50.5) Pub Date : 2024-07-24 Yao Dai, Manja Idorn, Manutea C. Serrero, Xiaoyong Pan, Emil A. Thomsen, Ryo Narita, Muyesier Maimaitili, Xiaoqing Qian, Marie B. Iversen, Line S. Reinert, Rasmus K. Flygaard, Muwan Chen, Xiangning Ding, Bao-cun Zhang, Madalina E. Carter-Timofte, Qing Lu, Zhuofan Jiang, Yiye Zhong, Shuhui Zhang, Lintai Da, Jinwei Zhu, Mark Denham, Poul Nissen, Trine H. Mogensen, Jacob Giehm Mikkelsen, Shen-Ying Zhang
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SMYD5 methylation of rpL40 links ribosomal output to gastric cancer Nature (IF 50.5) Pub Date : 2024-07-24 Juhyung Park, Jibo Wu, Krzysztof J. Szkop, Jinho Jeong, Predrag Jovanovic, Dylan Husmann, Natasha M. Flores, Joel W. Francis, Ying-Jiun C. Chen, Ana Morales Benitez, Emily Zahn, Shumei Song, Jaffer A. Ajani, Linghua Wang, Kamini Singh, Ola Larsson, Benjamin A. Garcia, Ivan Topisirovic, Or Gozani, Pawel K. Mazur
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Rapid sepsis test identifies bacteria that spark life-threatening infection Nature (IF 50.5) Pub Date : 2024-07-24
Hear the biggest stories from the world of science | 24 July 2024
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How do placebos ease pain? Mouse brain study offers clues Nature (IF 50.5) Pub Date : 2024-07-24
The discovery of a brain circuit involved in the pain-relieving effect of placebos could lead to new treatments.
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AI models fed AI-generated data quickly spew nonsense Nature (IF 50.5) Pub Date : 2024-07-24
Researchers gave successive versions of a large language model information produced by previous generations of the AI — and observed rapid collapse.
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Exclusive: the Trump administration demoted this climate scientist — now she wants reform Nature (IF 50.5) Pub Date : 2024-07-24
Virginia Burkett has filed a whistleblower complaint, asking for an investigation and better policies to protect scientists against political interference.
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Daily briefing: Hybrid AI supercharges climate models Nature (IF 50.5) Pub Date : 2024-07-24
Google AI predicts long-term climate trends and weather — in minutes. Plus, heaviest element yet within reach after major breakthrough and how to bring null results out of hiding.
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Forests don’t just absorb CO2 — they also take up methane Nature (IF 50.5) Pub Date : 2024-07-24 Patrik Vestin
Methane flux quantified at the woody surfaces of upland trees.
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How does the spliceosome dismantle itself? Nature (IF 50.5) Pub Date : 2024-07-24 Shasha Shi, Rui Zhao
Structural evidence reveals key steps during spliceosome disassembly.
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AI produces gibberish when trained on too much AI-generated data Nature (IF 50.5) Pub Date : 2024-07-24 Emily Wenger
Generative-AI models collapse when trained recursively.
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Cancer spread in the liver is unlocked from within Nature (IF 50.5) Pub Date : 2024-07-24 Katharina Woess, Direna Alonso-Curbelo
How healthy cells influence whether cancer spreads at a secondary site.
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Science must protect thinking time in a world of instant communication Nature (IF 50.5) Pub Date : 2024-07-24
E-mails and instant messaging are core to research — but also a distraction. Researchers should study their impact on science, and how they can claw back time to concentrate.
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This glowing speck is a freezing exoplanet six times the size of Jupiter Nature (IF 50.5) Pub Date : 2024-07-24
One of the closest extrasolar planets to our Solar System is the most frigid ever to be directly imaged.
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Operationally stable perovskite solar modules enabled by vapor-phase fluoride treatment Science (IF 44.7) Pub Date : 2024-07-25 Xiaoming Zhao, Peikun Zhang, Tianjun Liu, Bingkun Tian, Ying Jiang, Jinping Zhang, Yajing Tang, Bowen Li, Minmin Xue, Wei Zhang, Zhuhua Zhang, Wanlin Guo
The ever-increasing power conversion efficiency of perovskite solar cells has illuminated the future of the photovoltaic industry, but the development of commercial devices is hampered by their poor stability. In this study, we report a scalable stabilization method using vapor-phase fluoride treatment, which achieves 18.1%-efficient solar modules (228 square centimeters) with accelerated aging–projected
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Mapping Africa’s EV revolution Science (IF 44.7) Pub Date : 2024-07-25 Rose M. Mutiso
Six years ago, my colleagues and I published an article in the World Economic Forum asking if Africa was ready for the electric vehicle (EV) revolution. At that time, the African EV sector was nascent, and we concluded that more data and research were needed to draw firmer conclusions, emphasizing the absence of Africa-specific data in major EV publications and calling for dedicated analysis tailored